​Derris scandens (Climbing Derris)

Derris scandens (Climbing Derris)

Product Name: Деррис вьющийся, Derris scandens, Kletternder Derris, Derris trepadora, Derris grimpante, ديريس المتسلق, เดอริส สแกนเดนส์

Synonyms: Деррис, Вьющаяся деррис, Лиана деррис, Derris vine, Climbing derris, Derris scandens vine, Kletter-Derris, Derris grimpante, Derris enredadera, Derris trepador, ديريس, نبات الديريس, เดอริส, สมุนไพรเดอริส, เทียนเถาวัลย์แดง

Main indications for the use of Derris scandens: Knee osteoarthritis, lumbar pain syndrome, deforming spondyloarthrosis, chronic tendinitis, acute and subacute arthritis, myotonic syndrome, inflammation of periarticular soft tissues, degenerative-dystrophic changes of the spine, reactive synovitis, facet syndrome.

Use of Derris scandens in mixtures and complexes: Chronic pancreatitis, post-hepatitis syndrome, rheumatoid arthritis, systemic lupus erythematosus, myalgia of unknown etiology, fibromyalgia, deforming osteoarthritis of the hip joint, scapulohumeral periarthritis, pain syndrome in osteoporosis.

Pharmacological properties of Derris scandens: anti-inflammatory, analgesic, antioxidant, immunostimulating, cyclooxygenase-inhibiting, lipoxygenase cascade-inhibiting, muscle-relaxing, phytoestrogenic, non-steroidal-like, wound-healing, antinociceptive.

Dosage of Pharmaceutical Forms — Derris scandens

Powder — Derris scandens

Indications (Powder): Knee osteoarthritis, lumbar pain syndrome, tendinitis, myofascial pain syndrome, chronic arthritis, inflammation of the ligamentous apparatus, degenerative spinal diseases.

Standard Dosage (Powder): 1.5 grams of powder 2 times a day, with warm water, for 10–14 days. Take 30 minutes before meals.

Enhanced Dosage (Powder): 2 grams 3 times a day, for severe forms of osteoarthritis, active phase of spondyloarthrosis, exacerbation of chronic arthritis, pain associated with progressive tendinitis or facet syndrome.

Maximum Dosage (Powder): No more than 9 grams per day (3 grams 3 times a day), used in conditions of pronounced pain syndrome with no response to the standard regimen. Course duration — no more than 7 days, with mandatory monitoring of liver function.

Preventive Dosage (Powder): 0.5–1 gram once a day, in the morning, on an empty stomach, for 20 days, for chronic osteoarthritis, aging of connective tissue, a sedentary lifestyle, and during long-term joint immobilization. Courses — 2–3 times a year.

Pediatric Dosage (Powder): From 12 years, with a body weight of at least 40 kg — 0.5 grams 2 times a day, for 5–7 days. No safety data for under 12 years have been registered.

Contraindications (Powder): Individual intolerance, acute inflammatory diseases of the gastrointestinal tract, gastric and duodenal ulcers in the acute phase, pronounced hepatic insufficiency. No scientific contraindications have been registered during pregnancy, lactation, and in children under 12 years.

Side Effects (Powder): When the dosage is exceeded, dry mouth, dyspepsia, dizziness, skin rash, abdominal pain, and transient tachycardia may develop. All effects resolve after discontinuation of the drug.

Adjustment for Patient Body Weight (Powder): For body weight less than 60 kg — reduce the dose by 20%. For body weight more than 90 kg — increase the dose by 25% while maintaining the daily limit of 9 grams.

Preparation method (Powder): To prepare 100 grams of powder, the following are required: dry mature stems and bark of Derris scandens — 100 grams. The raw material is washed, dried at a temperature of 50–60 degrees Celsius for 48 hours to a residual moisture content of no more than 10%. Then ground in a micromill to a fraction of less than 250 microns. The resulting powder is sieved through sieve No. 200 and packaged in airtight containers.

Storage Conditions and Shelf Life (Powder): Store in a dry, dark place at a temperature of 15 to 25 degrees Celsius, in airtight packaging, protected from light and electromagnetic sources. Shelf life — 12 months. After opening, use within 30 days, provided it is stored in a tightly closed jar.

Extract — Derris scandens

Indications (Extract): Knee osteoarthritis, spondyloarthrosis, inflammation of periarticular tissues, chronic myositis, subacute arthritis, pain syndrome in degenerative changes of intervertebral discs, soft tissue rheumatic pain.

Standard Dosage (Extract): 500 milligrams of extract 2 times a day, after meals, with warm water. Course duration — 10 days.

Enhanced Dosage (Extract): 1000 milligrams of extract 3 times a day for pronounced joint pain syndrome, inflammatory changes of the facets, chronic osteoarthritis in the acute stage, as well as spondylitis and post-traumatic arthropathies.

Maximum Dosage (Extract): The daily dose should not exceed 3000 milligrams. Such a dosage is permissible short-term (no more than 5 days) in the absence of response to standard therapy, only under the control of liver function parameters.

Preventive Dosage (Extract): 250 milligrams of extract once a day for 20 days, during periods of seasonal exacerbation of joint diseases, with physical inactivity, after spinal surgeries. Courses are recommended to be repeated 2 times a year.

Pediatric Dosage (Extract): From 12 years and with a body weight of at least 40 kilograms — 250 milligrams once a day for 5 days. No safety data for under 12 years have been registered.

Contraindications (Extract): Hypersensitivity to components, gastric ulcer disease, acute pancreatitis, pregnancy and lactation — contraindications do not have sufficient scientific verification; use is possible only after assessing the risk and benefit. In children under 12 years, the contraindication remains.

Side Effects (Extract): The following have been observed: skin itching, heartburn, dizziness, flatulence, short-term increase in liver enzyme activity, a feeling of heaviness in the epigastric region in case of overdose. All effects disappear after discontinuation of the drug.

Adjustment for Patient Body Weight (Extract): For body weight up to 60 kilograms, it is recommended to reduce the dose by 25%. For body weight more than 90 kilograms, an increase in dose to 1200 milligrams 2 times a day is possible while maintaining the daily limit.

Preparation method (Extract): To prepare 100 grams of dry extract: ground dried stems of Derris scandens — 500 grams, 50% ethanol — 2000 milliliters. Infuse at a temperature of 70 degrees Celsius for 4 hours. Filter, concentrate at 45 degrees to a volume of 200 milliliters, dry in a drying chamber at 40–45 degrees to obtain a dry residue. Package in light-proof containers.

Storage Conditions and Shelf Life (Extract): Store in a dry, light-protected place, at a temperature of 15 to 25 degrees Celsius, in airtight containers. Shelf life — 18 months. After opening — use within 45 days, provided it is stored in a tightly closed container.

Alcohol-Based Tincture — Derris scandens

Indications (Tincture): Osteoarthritis with an inflammatory component, chronic back pain, myositis, ligament inflammation, reactive synovitis, lumbalgia, arthralgia in infectious joint lesions.

Standard Dosage (Tincture): 15 drops of tincture (approximately 0.75 ml) 2 times a day, diluted in 50 ml of warm water, 30 minutes before meals. Course — 10 days.

Enhanced Dosage (Tincture): 20 drops 3 times a day for pronounced joint pain, severe forms of spondyloarthrosis, as well as in the post-traumatic period with ligament sprains and joint capsule inflammation.

Maximum Dosage (Tincture): No more than 25 drops (1.25 ml) 3 times a day. Used only in conditions of short-term exacerbation (up to 5 days). Requires monitoring of liver function and general well-being.

Preventive Dosage (Tincture): 10 drops once a day, in the morning, on an empty stomach, for 14 days. Indicated for patients with chronic arthritis, a tendency to reactive joint inflammation, especially in spring and autumn. Courses — no more than 3 times a year.

Pediatric Dosage (Tincture): This form is contraindicated for children under 18 years due to ethanol content and the lack of safety data in pediatrics.

Contraindications (Tincture): Alcohol dependence, acute inflammatory diseases of the gastrointestinal tract, liver cirrhosis, hepatitis, mental disorders, pregnancy, lactation. Contraindicated in childhood. A complete contraindication in mild forms of hepatic insufficiency has not been scientifically registered — use is possible with caution.

Side Effects (Tincture): When the dose is exceeded, the following are possible: burning sensation in the stomach, dizziness, skin itching, facial flushing, short-term increase in blood pressure, insomnia. With prolonged use, an irritant load on the liver is possible.

Adjustment for Patient Body Weight (Tincture): For body weight less than 60 kilograms — no more than 10 drops per dose. For body weight more than 90 kilograms — an increase in the single dose to 25 drops is permissible, taking into account tolerability.

Preparation method (Tincture): To prepare 100 milliliters of tincture: dry ground stems of Derris scandens — 25 grams, 70% ethanol — 100 milliliters. Infuse in a glass container with a tightly closing lid at a temperature of 20–25 degrees Celsius for 10 days, shaking daily. Upon completion — strain through multi-layer gauze, pour into a dark glass bottle.

Storage Conditions and Shelf Life (Tincture): Store at a temperature of 15 to 25 degrees Celsius, in a dark place, in tightly sealed containers, away from sources of electromagnetic fields. Shelf life — 24 months. After opening — use within 60 days.

Oil Infusion — Derris scandens

Indications (Oil Infusion): Local inflammations of joints and tendons, myofascial pain syndromes, reactive periarthritis, neurogenic pain, ligament inflammation, tendinitis, intercostal neuralgia, osteochondrosis with local edema.

Standard Dosage (Oil Infusion): Externally, apply 3–5 ml of infusion to the affected area 2 times a day with light massage movements. Course — 10–14 days.

Enhanced Dosage (Oil Infusion): 5–7 ml 3 times a day, for pronounced joint inflammation, localized pain accompanied by edema and impaired mobility, in the period after injuries or during exacerbation of osteoarthritis.

Maximum Dosage (Oil Infusion): No more than 10 ml 3 times a day on an area of no more than 20×20 cm. Short-term use (up to 5 days) is permissible for acute pain syndrome. Do not apply to damaged skin.

Preventive Dosage (Oil Infusion): 2–3 ml once a day for 10 days for recurrent pain after physical exertion, chronic myalgia, a sedentary lifestyle, and during the rehabilitation period after injuries. Courses — 3–4 times a year.

Pediatric Dosage (Oil Infusion): From 7 years, with a body weight of at least 25 kilograms: 1–2 ml once a day, only on intact skin areas, for pain syndrome after physical exertion or mild arthralgia. Under 7 years — not recommended.

Contraindications (Oil Infusion): Allergy to components, dermatitis, eczema in the application area, pustular skin lesions, open wounds. During pregnancy and lactation, external use is possible, in the absence of irritation and only as indicated. Contraindicated in children under 7 years.

Side Effects (Oil Infusion): The following have been registered: skin hyperemia, itching, local burning, urticaria. In case of overdose, skin irritation, peeling, and contact dermatitis are possible. No systemic effects have been identified.

Adjustment for Patient Body Weight (Oil Infusion): For body weight less than 60 kilograms — use no more than 3 ml per dose. For body weight over 90 kilograms, an increase in volume to 7 ml per dose is permissible.

Preparation method (Oil Infusion): To prepare 100 milliliters of infusion: ground dried stems of Derris scandens — 25 grams, cold-pressed sesame oil — 100 milliliters. Pour the oil over the raw material, keep in a water bath at a temperature of 65 degrees Celsius for 4 hours. Cool, filter, pour into dark glass bottles. Add 0.1 grams of natural vitamin E as an antioxidant.

Storage Conditions and Shelf Life (Oil Infusion): Store in a cool dark place at a temperature of 10 to 20 degrees Celsius, away from heat sources, light, and electromagnetic radiation. Shelf life — 6 months. After opening, use within 30 days.

Dry Powder Extract — Derris scandens

Indications (Dry Powder Extract): Osteoarthritis, spondyloarthrosis, chronic inflammatory arthropathies, myalgia, tendinopathies, inflammation of the facet joints of the spine, post-traumatic pain syndrome, periarthritis.

Standard Dosage (Dry Powder Extract): 400 milligrams of dry extract 2 times a day, after meals. Course ranges from 10 to 14 days depending on the severity of the clinical picture.

Enhanced Dosage (Dry Powder Extract): 800 milligrams 3 times a day, for severe forms of osteoarthritis, the active phase of facet syndrome accompanied by significant restriction of mobility and pronounced pain, as well as recurrent inflammation of the capsular-ligamentous apparatus.

Maximum Dosage (Dry Powder Extract): The daily dose should not exceed 3000 milligrams (1000 milligrams 3 times a day). Use no more than 7 days. Laboratory monitoring of liver and kidney function is mandatory when prescribing this regimen.

Preventive Dosage (Dry Powder Extract): 200 milligrams once a day in the morning on an empty stomach for 20 days. Used for chronic osteoarthritis in remission, degenerative spinal changes, physical inactivity, and during the period of physiological aging of articular cartilage. Course repetition — every 6 months.

Pediatric Dosage (Dry Powder Extract): Permissible from 12 years with a body weight of at least 40 kilograms: 200 milligrams once a day for 5–7 days. Under 12 years, safety has not been confirmed.

Contraindications (Dry Powder Extract): Individual intolerance, exacerbation of ulcerative disease, severe hepatic insufficiency, acute inflammatory diseases of the gastrointestinal tract. There are no scientifically confirmed contraindications during pregnancy, lactation, and in children under 12 years, however, use is not recommended without specialist consultation.

Side Effects (Dry Powder Extract): Rarely: dyspepsia, headache, skin rash, drowsiness, increased ALT and AST activity. When doses are exceeded, toxic-allergic reactions, a feeling of heat, and tachycardia are possible.

Adjustment for Patient Body Weight (Dry Powder Extract): For patients with body weight less than 60 kilograms — reduction of dosage by 25%. For weight over 90 kilograms, an increase in dosage by 20% is possible while observing the maximum daily threshold.

Preparation method (Dry Powder Extract): To prepare 100 grams of dry extract: dried and ground stems of Derris scandens — 500 grams, purified water — 3000 milliliters. Boil in a water bath for 3 hours, filter, evaporate to 200 milliliters, then dry in a drying chamber at a temperature of 45 degrees to a powder mass. Pass through sieve No. 60, package in light-proof containers.

Storage Conditions and Shelf Life (Dry Powder Extract): Store in a dry, dark place at a temperature of 15 to 25 degrees Celsius, in airtight, light-proof packaging. Shelf life — 24 months. After opening — use within 60 days when stored in a tightly closed container.

Liquid Extract — Derris scandens

Indications (Liquid Extract): Deforming osteoarthritis, chronic synovitis, spondyloarthropathies, post-traumatic joint inflammations, soft tissue pain syndromes, neurogenic pain, myofascial dysfunction.

Standard Dosage (Liquid Extract): 5 milliliters (approximately 1 teaspoon) 2 times a day, dissolved in 50 milliliters of warm water, after meals. Duration of intake — from 10 to 14 days.

Enhanced Dosage (Liquid Extract): 7.5 milliliters 3 times a day in the presence of pronounced pain syndrome, enhanced inflammatory component, or ineffectiveness of the standard regimen. Used in cases of reactive arthritis, severe facet inflammation, chronic joint pain due to cartilage degeneration.

Maximum Dosage (Liquid Extract): No more than 10 milliliters 3 times a day (30 ml/day) short-term, no longer than 5 days. Monitoring of liver function is mandatory, especially with concomitant gastrointestinal diseases.

Preventive Dosage (Liquid Extract): 3 milliliters once a day, dissolved in warm water, in the morning on an empty stomach. Used for a tendency to inflammatory joint changes, physical inactivity, in old age, and after prolonged loads. Courses — 14 days, 2–3 times a year.

Pediatric Dosage (Liquid Extract): From 12 years, with a body weight of at least 40 kilograms — 2.5 milliliters once a day, for 5 days. Under 12 years, use is not recommended due to the lack of an evidence base.

Contraindications (Liquid Extract): Hypersensitivity to components, severe liver diseases, active ulcerative disease, pregnancy and lactation — contraindications have not been scientifically confirmed, however, it is recommended to avoid use without medical supervision. In children under 12 years — contraindicated.

Side Effects (Liquid Extract): Scientifically recorded: dyspeptic phenomena, dizziness, short-term tachycardia, facial flushing, skin itching. All effects resolve after discontinuation of the drug.

Adjustment for Patient Body Weight (Liquid Extract): Body weight less than 60 kilograms — reduction of dosage by 20%. Body weight more than 90 kilograms — increase in dosage to 8 milliliters per dose, with tolerability monitoring.

Preparation method (Liquid Extract): For 100 milliliters of liquid extract: stems of Derris scandens — 100 grams, purified water — 1000 milliliters. Boil over low heat for 2 hours, filter, evaporate at a temperature of 60 degrees to a volume of 100 milliliters. Add 0.2 grams of sorbic acid as a preservative. Pour into a sterile dark glass bottle.

Storage Conditions and Shelf Life (Liquid Extract): Store at a temperature of 8 to 15 degrees Celsius, in a dark place, protected from light and EMI. Shelf life — 6 months. After opening — use within 21 days, store in the refrigerator.

Topical Patch — Derris scandens

Indications (Topical Patch): Localized pain in osteoarthritis, chronic pain syndrome in the lumbar region, inflammations of periarticular soft tissues, myositis, tendinopathies, periarthritis, facet syndrome of the spine.

Standard Dosage (Topical Patch): One patch of 10×14 cm is applied to the painful area for 6–8 hours once a day. Course — 7 days.

Enhanced Dosage (Topical Patch): One patch 2 times a day (morning and evening), each for 6 hours, for pronounced local inflammation, acute pain syndrome, impaired mobility, including lumbalgia and radicular syndromes.

Maximum Dosage (Topical Patch): No more than three patches within 24 hours (applied to different areas, do not overlap). Permissible for resistant pain, no more than 5 days in a row.

Preventive Dosage (Topical Patch): One patch every other day at night, course — 5 applications. Used for chronic osteoarthritis, static loads, occupational risks in drivers, operators, and people working standing for long periods. Prevention is carried out 2–3 times a year.

Pediatric Dosage (Topical Patch): From 14 years: 1/2 of a standard patch (cut) for 4 hours once a day. Under 14 years, contraindicated due to increased skin permeability and the lack of an evidence base.

Contraindications (Topical Patch): Pustular rashes in the application area, dermatitis, psoriasis, eczema, increased skin sensitivity, allergy to patch components. Pregnancy, lactation — only short-term external use on small areas is permissible. Contraindicated for children under 14 years.

Side Effects (Topical Patch): Scientifically registered: contact dermatitis, itching, redness, peeling, skin hyperesthesia. In rare cases — irritation and local pain.

Adjustment for Patient Body Weight (Topical Patch): Adjustment is not required, as the form is intended for local use. For body weight less than 50 kilograms — limit the application area to one area up to 10×10 cm.

Preparation method (Topical Patch): For 100 patches: thick extract of Derris scandens — 200 grams, crystalline menthol — 5 grams, camphor — 3 grams, base (mixture of polyvinyl alcohol and gelatin) — 300 grams. Dissolve the extract in the base, add menthol and camphor, mix until homogeneous, apply evenly in a 2 mm layer on a fabric backing and dry at a temperature of 40 degrees for 12 hours. Cut into strips of 10×14 cm, package in airtight individual bags.

Storage Conditions and Shelf Life (Topical Patch): Store at a temperature of 5 to 25 degrees Celsius, in a dry, light-protected place. Avoid exposure to direct sunlight and heat. Shelf life — 24 months. After opening the package, use within 12 hours.

Cosmetic Product (Lotion/Milk) — Derris scandens

Indications (Cosmetic Product): Aging skin with signs of inflammation, dryness and peeling, tendency to local edema, rosacea, skin hypersensitivity, dermatomyalgia, inflammatory processes in the area of joints and muscles in mild form, skin sensitivity after exertion.

Standard Dosage (Cosmetic Product): Apply 1–2 ml of lotion or milk to cleansed skin 1–2 times a day, evenly distributing in a thin layer over the affected or sensitive area. Course — 14 days.

Enhanced Dosage (Cosmetic Product): Use up to 3 times a day, 2–3 ml each, for pronounced skin sensitivity, inflammatory reactions after physical exertion, irritation in flexion areas, in patients with pronounced signs of skin dehydration or local reactivity.

Maximum Dosage (Cosmetic Product): Up to 4 ml 3 times a day on an area up to 100 cm². Continuous use for a maximum of 7 days is permissible, then a break of at least 5 days is recommended. Do not apply to damaged skin or mucous membranes.

Preventive Dosage (Cosmetic Product): 1 ml once a day for 10 days for seasonal dry skin, a tendency to redness, reactivity after heat or cold, age-related skin changes, as part of preventive care in persons over 40 years. Repeat the course once every 2 months.

Pediatric Dosage (Cosmetic Product): Permissible from 6 years for sensitive skin: no more than 0.5 ml once a day, only as indicated, in the absence of allergic reactions. Under 6 years, not recommended.

Contraindications (Cosmetic Product): Allergy to components, acute inflammatory dermatoses, weeping wounds, individual hypersensitivity to the essential components of the formula. Contraindications during pregnancy and lactation have not been scientifically registered, however, use should preferably be limited to small areas and under control. Not recommended for children under 6 years.

Side Effects (Cosmetic Product): Local redness, burning sensation, itching, peeling, dryness. When the dose is exceeded or applied to damaged skin, increased local inflammatory reaction is possible.

Adjustment for Patient Body Weight (Cosmetic Product): Not required, however, for body weight less than 50 kilograms, it is recommended to reduce the area of application. For body weight more than 90 kilograms, adjustment is not required.

Preparation method (Cosmetic Product): For 100 milliliters: extract of Derris scandens — 2 grams, rosemary hydrolate — 20 milliliters, jojoba oil — 5 milliliters, emulsifier (cetearyl glucoside) — 3 grams, distilled water — 70 milliliters. The components are mixed in two stages: the oil and aqueous phases are heated to 65 degrees Celsius, combined with constant stirring, cooled to 30 degrees. Add the extract, then the hydrolate and preservative (0.5 grams of benzyl alcohol). The finished product is packaged in opaque bottles.

Storage Conditions and Shelf Life (Cosmetic Product): Store at a temperature of 5 to 20 degrees Celsius, in a dark place, away from light and heat sources. Shelf life — 6 months. After opening, use within 30 days, avoiding contact with contaminated surfaces of the dispenser.

Restorative Ointment Form — Derris scandens

Indications (Restorative Ointment): Inflammatory and traumatic skin and soft tissue injuries, subacute dermatitis, local inflammations in joint areas, post-injection infiltrates, bruises, superficial neurodermatitis, skin irritation after physical exertion, scar-adhesive skin changes.

Standard Dosage (Restorative Ointment): Apply 2–3 grams of ointment (a full teaspoon) to the affected area 1–2 times a day. Course — 7–10 days.

Enhanced Dosage (Restorative Ointment): Apply 3–5 grams 3 times a day for pronounced inflammatory skin reactions, protracted post-traumatic infiltrates, and chronic local myositic-dystrophic foci. The maximum period of use of the enhanced regimen is 5 days.

Maximum Dosage (Restorative Ointment): No more than 6 grams per application and no more than 18 grams per day. Use only under dermatological supervision for severe soft tissue inflammations accompanied by edema and pain syndrome.

Preventive Dosage (Restorative Ointment): 1–1.5 grams (half a teaspoon) once a day for 5 days for a tendency to skin inflammations, scarring, to prepare the skin for physical exertion, in patients with professional activity associated with microtraumas. Preventive courses — 2 times a year.

Pediatric Dosage (Restorative Ointment): Permissible from 7 years: 0.5–1 gram of ointment once a day on limited areas, for mild bruises, skin irritation, prevention of chafing. Not used under 7 years.

Contraindications (Restorative Ointment): Acute pustular skin processes, trophic ulcers, open wounds, individual intolerance. Contraindications during pregnancy, lactation, and in children under 7 years have not been scientifically registered, but use should be limited to small doses and short courses.

Side Effects (Restorative Ointment): Rarely: burning, hyperemia, peeling, local pain upon application, allergic reactions when the dosage is exceeded. With prolonged use, contact dermatitis may develop.

Adjustment for Patient Body Weight (Restorative Ointment): Adjustment is not required for external use, but for weight less than 50 kilograms, it is recommended to reduce the area of application and use no more than 1 gram at a time.

Preparation method (Restorative Ointment): For 100 grams of ointment: thick extract of Derris scandens — 10 grams, lanolin — 15 grams, medical petroleum jelly — 45 grams, St. John's wort oil — 10 grams, emulsifier (cetearyl alcohol) — 5 grams, purified water — 15 grams. Heat the oil phase to 65 degrees, add the extract, emulsify with the aqueous phase until homogeneous, cool to 30 degrees with constant stirring. Package in aluminum tubes or dark glass jars.

Storage Conditions and Shelf Life (Restorative Ointment): Store in a cool place at a temperature of 8 to 15 degrees Celsius, away from light and heating devices. Shelf life — 12 months. After opening, use within 30 days, avoiding water and air entering the package.

Toxicity and Biosafety of Derris scandens

Studies conducted on laboratory animals show a high biosafety profile of Derris scandens. In an experiment on mice and rats with oral administration of dry extract at dosages up to 10,000 milligrams per kilogram of body weight, no signs of toxicity or fatalities were recorded. Accordingly, the LD₅₀ exceeds 10 g/kg, which indicates extremely low acute toxicity and allows the use of the drug at therapeutic doses without the risk of intoxication in case of accidental overdose.

Long-term administration of the drug for 28 days also did not cause significant histopathological deviations in the tissues of the liver, kidneys, stomach, and spleen. Liver enzyme levels (ALT, AST) remained within normal limits. No behavioral disorders, motor activity changes, or body weight changes were observed in the animals.

Thus, Derris scandens demonstrates a favorable toxicological profile and can be considered safe for oral and external use in recommended dosages. Use in humans, according to clinical trial data, is also accompanied by an extremely low frequency of side effects, mostly limited to local reactions.

Reference: https://he01.tci-thaijo.org/in...

Pharmacodynamics — Derris scandens

The pharmacodynamics of Derris scandens are determined primarily by the action of flavonoid glycosides, triterpenes, and phenolic compounds. The most studied component is genistein-7-O-glycoside, which has a modulating effect on enzyme systems associated with inflammation. It inhibits cyclooxygenase-2 (COX-2) activity, reduces the expression of pro-inflammatory cytokines (TNF-α, IL-6), and suppresses prostaglandin synthesis. An ability to suppress lipoxygenase (5-LOX) activity has also been noted, which complements the anti-inflammatory spectrum of action.

A number of studies show that extracts of Derris scandens have an antioxidant effect, preventing lipid peroxidation and stabilizing cell membranes. The drug acts predominantly at the local and systemic levels, showing activity in connective tissue and muscle structures. By suppressing the activity of myeloperoxidase and NO synthase, the plant has a pronounced effect on inflammatory mediators and oxidative stress.

The effect on skin receptors and subcutaneous microcirculation provides an additional mild muscle-relaxing effect. Immunomodulatory influence is manifested in the activation of the T-cell component and enhanced production of interleukin-2 while maintaining overall immune balance.

References:
https://he01.tci-thaijo.org/in...
https://he01.tci-thaijo.org/in...
https://ccpe.pharmacycouncil.o...

Pharmacokinetics — Derris scandens

Pharmacokinetic data on Derris scandens are limited, however, generalized information on the metabolism of flavonoid and triterpene compounds with various routes of administration is available. With oral intake of extracts, absorption occurs mainly in the small intestine, with partial participation of microflora capable of hydrolyzing glycosidic bonds. Active metabolites undergo phase II metabolism in the liver (conjugation with glucuronic and sulfuric acids), then are distributed in plasma and tissues, mainly in the liver, muscle tissue, and joint structures.

Excretion is carried out primarily through the kidneys with urine in the form of polar metabolites, and to a lesser extent with bile. Transdermal forms (ointment, infusion, patch) have predominantly local action, with limited systemic absorption. Active components may partially penetrate the skin, accumulating in the dermis and subcutaneous tissue. With external use, systemic bioavailability is significantly lower, which reduces the risk of systemic side reactions.

Since many of the active compounds of Derris scandens belong to the class of polyphenols, the rate of their absorption and biotransformation depends on the state of the gastrointestinal tract, the composition of the microbiota, and the enzymatic activity of the liver.

References:
https://he01.tci-thaijo.org/in...
https://ccpe.pharmacycouncil.o...

Mechanisms of Action and Scientific Rationale — Derris scandens

The pharmacological activity of Derris scandens is explained by the action of flavonoids and triterpenes on key signaling pathways of inflammatory regulation. Genistein glycosides included in the extract inhibit the NF-κB cascade, reducing the transcription of pro-inflammatory genes and the production of mediators such as TNF-α, IL-1β, and IL-6. Suppression of COX-2 and 5-LOX enzyme activity involved in the biosynthesis of prostaglandins and leukotrienes, respectively, has also been established. This action is predominantly tissue-specific, with localization in connective tissue and epithelial structures.

Triterpenes and phenolic compounds reduce the level of reactive oxygen species (ROS) through inhibition of NADPH-oxidase enzyme and stimulation of the expression of endogenous antioxidant enzymes such as superoxide dismutase. The immunomodulatory effect is realized through activation of TLR4 receptors and increased production of IL-2, contributing to the restoration of the cellular immune response.

The effect on cutaneous-muscular receptors and the capillary link of microcirculation explains the local effects of the infusion and patches. Through interaction with glucocorticoid receptors and modulation of the JAK/STAT signaling pathway, a mild anti-edematous and analgesic effect is possible.

References:
ttps://he01.tci-thaijo.org/in...
https://he01.tci-thaijo.org/in...
https://www.ncbi.nlm.nih.gov/p...

Synergy — Derris scandens

A potentiating interaction of Derris scandens extract with flavonoids of other plants has been proven, including curcumin, green tea catechins, and soy isoflavones. These combinations enhance the antioxidant effect and inhibition of inflammatory mediators, exhibiting an additive or synergistic effect at the level of COX enzymes and the NF-κB cascade. In in vivo and in vitro studies, an enhancement of immunomodulatory activity in combination with extracts of Andrographis paniculata and Glycyrrhiza glabra has also been described, especially with simultaneous activation of T-cells and a decrease in IL-6 production.

References:
https://he01.tci-thaijo.org/in...
https://www.sciencedirect.com/science/article/abs/pii/S0378874122000504
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303794

Geography of Use and Traditional Medicine — Derris scandens

Derris scandens is traditionally used in the medical and ritual practices of the peoples of Southeast Asia, especially in Thailand, Laos, Cambodia, Vietnam, the southern provinces of China, and India. The plant is part of the ethnobotanical heritage of Mon-Khmer, Khmer, Lanna, and Thai medical schools. In Thai traditional medicine, it is known as "Thao-ia" and is used mainly as an external remedy in the form of compresses, warm wraps, and also as an internal form — infusions and decoctions from stems and bark. The raw material is collected mainly in the dry season and processed manually, including in monastic hospitals.

In Indian systems of traditional treatment, the plant was included in Ayurvedic recipes as "Banna tulasi" or in the context of "Climbing Tulasi," used mainly for disorders of the fiery or wind dosha. In village practices of the southern Indian subcontinent, decoctions from the vines were used in field conditions for temporary pain relief and recovery after intensive work. Malaysian and Burmese traditions also included Derris scandens in medicinal complexes based on tinctures, including with the addition of wood ash, honey, and spices.

Historically, mentions of the plant are recorded in folk medical texts of northern Thailand of the Lanna period (14th–16th centuries), where it was considered "warming the vessels" and was used as part of moist steam inhalations and ritual baths. In some monastic practices, it was included in ritual compositions for rubbing and anointing before meditations, especially in the context of internal discipline and bodily preparation. Use in smoke forms (smoking of ground wood and bark) is recorded among certain Lao ethnic subgroups, in particular the Hmong people, where such use was accompanied by chanting and served to remove internal "fire of pain."

In folk culture, the plant was perceived as a "protector of tendons" and "support of the spine" — such metaphorical definitions are found in the oral tales of the Isan peoples (northeast Thailand). Among the indigenous peoples of southern Thailand, practices of applying a paste of crushed stem to the body as "magical protection" from fatigue and pain during long journeys are found. In the vicinity of Chiang Mai, a mixture of ground vine and sesame oil was used as the basis for a ritual amulet during river rafting.

In addition to medicinal and ritual use, Derris scandens is sometimes mentioned in regional beliefs as a "plant that untangles the karma of pain," with reference to bodily suffering as part of the spiritual path. These ideas were common in the context of folk Buddhism and were integrated into individual practices of self-purification. In the modern territory of Thailand, Laos, and parts of Myanmar, the plant continues to be used as part of folklore medicine and is passed down in family recipes among hereditary healers.

Albina K.

Hello! I thank Vladimir for the treatment of my plantar fasciitis. I suffered from severe heel pain for 6 months. It was impossible to fully step on the foot without pain. The foot bent during walking with great effort; I had to step on the outer side of the foot to bend it. There were significant growths on the heel, like bumps. The swelling of the foot, especially the heel, constantly tormented me with pain. The doctor prescribed treatment with ultrasound and laser. I underwent two courses of physiotherapy, there was a temporary improvement, but after a month it recurred again. After consultation, Vladimir prescribed a course of treatment with the ODS mixture, + "Tal-Wal-Paeng" (Derris scandens) + whale cartilage glucosamine. I felt improvement after a month of taking it. The foot began to bend, I felt strength in my legs, the swelling of the foot stopped and never returned. At the same time, I followed the 7 Angels nutrition system. The result of the treatment amazed me. I also ordered the 7 Herbs ointment. My brother had a severe knee bruise; the kneecaps were almost dark blue-black in color. He applied the 7 Herbs ointment to the bruise, and by morning the bruise had resolved so much that only a small yellow spot remained. The result is stunning.