Filipendula ulmaria (Meadowsweet)

Filipendula ulmaria (Meadowsweet)

Product Name: Лабазник вязолистный, Filipendula ulmaria, Mädesüß, Reina de los prados, Reine-des-prés, لحية الماعز, ลาบาซนิก, Labaznik, Лабазник, Filipendula, Филипендулла, Filipendula, Filipendula, Філіпендула, Filipendula, Filipendula

Synonyms: таволга вязолистная, таволга, королева лугов, Filipendula hexapetala, meadowsweet, mead wort, Mädesüß, Wiesenkönigin, ulmaria, reina de los prados, hierba de los prados, Reine-des-prés, spirée ulmaire, عشبة المروج, رَيْنَةُ المروج, ลาบาซนิก, หญ้าทุ่ง

Parts Used: flowers, leaves, shoots, rhizomes, herb.

Main Indications for Use of Filipendula ulmaria: Acute and chronic inflammatory diseases of the gastric mucosa, gastric and duodenal ulcer, ulcerative colitis, bacterial diarrhea, bronchitis with viscous sputum, osteoarthritis, gout, infectious diseases of the respiratory tract, hyperthermia, primary hypertension, rheumatoid arthritis, hypercoagulation, hyperlipidemia, infectious diseases of the urinary tract.

Use of Filipendula ulmaria in mixtures and complexes: Systemic vasculitis, chronic renal failure, systemic lupus erythematosus, allergic dermatitis, neurodermatitis, cerebral atherosclerosis, chronic ischemic heart disease, chronic pancreatitis, postmenopausal osteoporosis, viral infections, secondary anemia, hyperestrogenism.

Pharmacological Properties of Filipendula ulmaria: anti-inflammatory, analgesic, antipyretic, diuretic, antiseptic, anticoagulant, antirheumatic, sedative, astringent, antibacterial, antioxidant, antihistamine, spasmolytic, hypolipidemic, hepatoprotective, anticarcinogenic, immunostimulating, wound-healing, antimutagenic.

Dosage of Pharmacological Forms — Filipendula ulmaria

Powder — Filipendula ulmaria

Indications (Powder): Hypercoagulation, gastric ulcer, duodenal ulcer, hyperthermia, osteoarthritis, rheumatoid arthritis, infectious diseases of the urinary tract, bacterial diarrhea, gout.

Standard Dosage (Powder): 1 gram of powder 3 times a day after meals, with warm water. Duration of intake — up to 4 weeks.

Enhanced Dosage (Powder): 1.5 grams of powder 3 times a day for osteoarthritis, ulcerative colitis, bacterial diarrhea, rheumatoid arthritis. Duration of intake — no more than 14 days.

Maximum Dosage (Powder): Up to 2 grams of powder 3 times a day. Used for acute inflammations of the gastric mucosa, severe forms of rheumatism, infectious diarrhea. No more than 7 days consecutively.

Preventive Dosage (Powder): 0.5 grams once a day. Recommended for patients with chronic diseases of the stomach, joints, and a tendency to thrombosis. Frequency of intake — 2 weeks of intake, 2 weeks break, for 3 months.

Pediatric Dosage (Powder): For children from 6 years of age with body weight more than 20 kg — 250 mg of powder 2 times a day. For children under 6 years of age, not recommended without specialist supervision.

Contraindications (Powder): Gastric ulcer in the acute stage, individual intolerance. Data on contraindications during pregnancy, lactation, and in children under 3 years of age have not been scientifically registered.

Side Effects (Powder): With overdose, headache, nausea, gastric spasms are possible. Isolated cases of allergic rash have been registered.

Adjustment for Patient Body Weight: For body weight less than 60 kg — the dosage is reduced by 25%. For body weight more than 90 kg — an increase of dosage to the upper limit of the standard is possible.

Preparation Method (Powder): The dry herb of meadowsweet is cleaned of coarse impurities, withered at a temperature not exceeding 40 degrees Celsius in the shade until completely dry. It is ground to a powder state in a mill or coffee grinder. For 100 grams of powder, 120 grams of dried herb are required.

Storage Conditions and Shelf Life (Powder): Store in an airtight glass container, in a dark, dry place at a temperature not exceeding 25 degrees Celsius. Avoid exposure to direct light and sources of electromagnetic radiation. Shelf life — 12 months. After opening the package, use within 45 days.

Dry Extract — Filipendula ulmaria

Indications (Dry Extract): Acute inflammatory diseases of the gastric mucosa, ulcerative colitis, rheumatoid arthritis, gout, bacterial diarrhea, hypercoagulation, osteoarthritis, primary hypertension.

Standard Dosage (Dry Extract): 200 mg of dry extract 2 times a day after meals. Duration of intake — 3 weeks.

Enhanced Dosage (Dry Extract): 300 mg 3 times a day for acute joint inflammations, ulcerative colitis, pronounced hypercoagulation. Duration — no more than 10 days.

Maximum Dosage (Dry Extract): Up to 400 mg 3 times a day. Used in short-term therapy of severe inflammatory diseases of the gastrointestinal tract and joints. Duration no more than 5 days.

Preventive Dosage (Dry Extract): 100 mg once a day. Recommended for patients with chronic inflammatory diseases of the stomach, joints, and a tendency to thrombosis. Course — 30 days, repeat 3 times a year.

Pediatric Dosage (Dry Extract): From 7 years of age and with body weight from 25 kg — 50 mg once a day. Below 7 years of age, use is not recommended.

Contraindications (Dry Extract): Individual intolerance, exacerbation of gastric ulcer. Data on safety during pregnancy and lactation have not been registered.

Side Effects (Dry Extract): Dyspeptic disorders, flatulence, rarely — skin allergic reactions when the dosage is exceeded, may occur.

Adjustment for Patient Body Weight: For weight less than 60 kg — reduction of dosage by 20%. For body weight more than 90 kg — increase of the standard dosage to the maximum permissible.

Preparation Method (Dry Extract): To obtain 100 grams of dry extract, 500 grams of meadowsweet herb are used. The raw material is poured with 50% ethyl alcohol in a ratio of 1:10, infused for 72 hours at a temperature of 25–28 degrees, then filtered, the extract is thickened in a water bath at a temperature not exceeding 60 degrees, and dried in a vacuum drying chamber to a dry residue state.

Storage Conditions and Shelf Life (Dry Extract): Store in a tightly closed dark glass container, at a temperature from 5 to 25 degrees Celsius, in conditions of absence of moisture and direct light. Shelf life — up to 2 years. After opening — use within 60 days.

Alcohol Tincture — Filipendula ulmaria

Indications (Alcohol Tincture): Acute and chronic inflammatory diseases of the stomach, duodenal ulcer, rheumatoid arthritis, osteoarthritis, primary hypertension, bacterial diarrhea, infectious diseases of the urinary tract.

Standard Dosage (Alcohol Tincture): 20 drops 3 times a day, diluted in 50 ml of water, 20 minutes before meals. Course of treatment — 3 weeks.

Enhanced Dosage (Alcohol Tincture): 30 drops 3 times a day for pronounced pain and joint inflammations, for hypercoagulation and acute forms of ulcerative colitis. Course — up to 10 days.

Maximum Dosage (Alcohol Tincture): 40 drops 3 times a day. Permissible only for intensive therapy of acute forms of rheumatism, severe hyperthermia, active inflammatory processes of the gastrointestinal tract. Duration — no more than 5 days.

Preventive Dosage (Alcohol Tincture): 15 drops once a day. Recommended for patients with chronic osteoarthritis, thrombophlebitis, colitis. Course — 30 days, repeat every 3 months.

Pediatric Dosage (Alcohol Tincture): Not recommended for children under 12 years of age due to ethanol content. From 12 years of age — 5–10 drops 1–2 times a day in diluted form.

Contraindications (Alcohol Tincture): Alcoholism, liver diseases, epilepsy, pregnancy, age under 12 years. Data on safety during lactation have not been registered.

Side Effects (Alcohol Tincture): With overdose, dizziness, drowsiness, increased intestinal peristalsis, mucosal irritation are possible.

Adjustment for Patient Body Weight: For patients with weight less than 60 kg, a reduction of dosage by 20% is recommended. For weight more than 90 kg, an increase of the daily dosage by 10 drops per day is permissible.

Preparation Method (Alcohol Tincture): To prepare 100 grams of tincture, 20 grams of ground dry meadowsweet herb and 80 grams of 70% ethyl alcohol are required. Infuse in a dark glass container at room temperature for 10 days, shaking periodically. After completion, filter through thick cloth and pour into sterile vials.

Storage Conditions and Shelf Life (Alcohol Tincture): Store in a hermetically closed dark glass vial at a temperature from 5 to 25 degrees Celsius, in a place protected from light and EMI. Shelf life — up to 3 years. After opening, use within 90 days.

Oil Infusion — Filipendula ulmaria

Indications (Oil Infusion): Osteoarthritis, rheumatoid arthritis, varicose veins, inflammatory dermatoses, allergic dermatitis, trophic ulcers, neurodermatitis.

Standard Dosage (Oil Infusion): Topically — apply a thin layer 2 times a day to cleansed skin. Lightly rub into the area of joints or inflamed areas.

Enhanced Dosage (Oil Infusion): Apply 3–4 times a day for acute joint inflammations, pronounced pain, or in the presence of chronic skin lesions.

Maximum Dosage (Oil Infusion): Up to 6 applications per day on limited areas of the body (no more than 30% of the skin surface) for 5 days for pronounced pain syndrome or exacerbation of rheumatism.

Preventive Dosage (Oil Infusion): Once a day before bedtime, rubbing into the area of joints, for chronic osteoarthritis, thrombophlebitis, neurodermatitis. Course — 30 days, repeat after 2 months.

Pediatric Dosage (Oil Infusion): From 6 years of age — single application once a day. Use with caution, avoid areas with damaged skin. Suitable as a symptomatic topical remedy.

Contraindications (Oil Infusion): Individual intolerance, exudative forms of dermatitis, acute skin infections. Data on contraindications during pregnancy and lactation have not been registered.

Side Effects (Oil Infusion): Contact dermatitis, skin hyperemia, burning, peeling are possible in case of individual sensitivity or when the dosage is exceeded.

Adjustment for Patient Body Weight: Correction is not required for topical use. For a total body weight of less than 40 kg, apply the minimum possible amount.

Preparation Method (Oil Infusion): For 100 grams of oil infusion: 25 grams of ground dry meadowsweet herb are poured with 75 grams of unrefined coconut oil. Infuse in a water bath at a temperature of 40–45 degrees Celsius for 2 hours. Then keep in a dark place at room temperature for 7 days, filter through gauze.

Storage Conditions and Shelf Life (Oil Infusion): Store in a tightly closed dark glass container, at a temperature from 5 to 20 degrees Celsius, in a place protected from light and moisture. Avoid contact with metal objects. Shelf life — up to 12 months. After opening, use within 60 days.

Vaginal Suppository — Filipendula ulmaria

Indications (Vaginal Suppository): Bacterial vaginosis, candidal vulvovaginitis, atrophic vaginitis, nonspecific colpitis, inflammation of the cervix, chronic cervicitis, vaginal itching of non-inflammatory origin.

Standard Dosage (Vaginal Suppository): 1 suppository (2 g) is inserted vaginally once a day, at night. Course of use — 7–10 days.

Enhanced Dosage (Vaginal Suppository): 1 suppository 2 times a day (morning and evening) for acute inflammatory processes (bacterial vaginosis, moderate candidiasis). Duration of the course — up to 7 days.

Maximum Dosage (Vaginal Suppository): 3 suppositories per day — only as prescribed by a specialist, for pronounced clinical manifestations of colpitis and cervicitis. Course — no more than 5 days.

Preventive Dosage (Vaginal Suppository): 1 suppository every other day for 14 days. Recommended for postmenopausal women with atrophic changes of the mucosa, patients after antibacterial therapy, with chronic inflammatory diseases of the pelvic organs.

Pediatric Dosage (Vaginal Suppository): Not recommended for use in girls before the onset of menarche. From 12 years of age — only as prescribed by a doctor.

Contraindications (Vaginal Suppository): Acute inflammatory processes with purulent discharge, individual intolerance to components. Data on safety during pregnancy and lactation have not been registered.

Side Effects (Vaginal Suppository): Mild burning, itching, allergic reaction to the suppository shell. With overdose — increased local hyperemia.

Adjustment for Patient Body Weight: Dose adjustment is not required.

Preparation Method (Vaginal Suppository): To prepare 10 suppositories of 2 g: 5 grams of dry meadowsweet extract are mixed with 2 grams of cocoa butter and 13 grams of coconut oil. The oils are melted in a water bath at a temperature not exceeding 40 degrees Celsius, the extract is added with constant stirring until a homogeneous mass is obtained. Poured into molds and cooled at a temperature of 4–6 degrees for 3 hours.

Storage Conditions and Shelf Life (Vaginal Suppository): Store in a refrigerator at a temperature from 2 to 8 degrees Celsius, in an airtight package protected from light. Avoid overheating. Shelf life — 6 months. After opening, use within 10 days.

Rectal Suppository — Filipendula ulmaria

Indications (Rectal Suppository): Ulcerative colitis, proctitis, hemorrhoids, thrombosis of hemorrhoidal veins, anal fissure, irritable bowel syndrome with a predominance of inflammation, inflammation of the rectum.

Standard Dosage (Rectal Suppository): 1 suppository (2 g) once a day, at night, rectally, after preliminary defecation. Course — 10 days.

Enhanced Dosage (Rectal Suppository): 1 suppository 2 times a day (morning and evening) for exacerbation of ulcerative colitis, pronounced inflammation of the rectum, anal fissure. Course — up to 7 days.

Maximum Dosage (Rectal Suppository): Up to 3 suppositories per day — short-term, for exacerbation of thrombosed hemorrhoids, for 3–5 days.

Preventive Dosage (Rectal Suppository): 1 suppository every other day, at night. Indications: chronic hemorrhoids, irritable bowel syndrome, thrombophlebitis of the rectal plexus. Course — 20 days, repeat every 3 months.

Pediatric Dosage (Rectal Suppository): From 7 years of age — ½ suppository once a day. From 12 years of age — 1 suppository. Only in the presence of indications and under specialist supervision.

Contraindications (Rectal Suppository): Acute anal bleeding, rectal tumors, individual sensitivity. Data on safety during pregnancy and lactation have not been registered.

Side Effects (Rectal Suppository): Rarely — burning sensation, false urges, slight loosening of the stool. With overdose — irritation of the rectal mucosa.

Adjustment for Patient Body Weight: For patients with body weight less than 40 kg — use ½ suppository. For weight more than 90 kg, doubling the frequency of use at the standard dose is possible.

Preparation Method (Rectal Suppository): For 10 suppositories: 5 grams of dry meadowsweet extract, 3 grams of coconut oil, 12 grams of cocoa butter. The oils are melted in a water bath, the extract is added. The mixture is thoroughly stirred and poured into suppository molds. Cooled until solidified in a refrigerator.

Storage Conditions and Shelf Life (Rectal Suppository): Store at a temperature from 2 to 8 degrees Celsius, in a hermetically closed container, without access to light and moisture. Shelf life — 6 months. After opening, use within 7 days.

Nasal Drops — Filipendula ulmaria

Indications (Nasal Drops): Acute rhinitis, chronic rhinitis, allergic rhinitis, vasomotor rhinitis, sinusitis, post-viral inflammatory syndrome of the nasal mucosa.

Standard Dosage (Nasal Drops): 2 drops in each nasal passage 3 times a day. Course — 7–10 days.

Enhanced Dosage (Nasal Drops): 3–4 drops in each nasal passage up to 4 times a day for acute viral rhinitis, allergic forms, sinusitis. Course — 5–7 days.

Maximum Dosage (Nasal Drops): Up to 5 drops in each nasal passage 5 times a day. Allowed only short-term (no more than 3 days) for severe congestion and swelling of the mucous membrane.

Preventive Dosage (Nasal Drops): 1 drop in each nasal passage once a day during the period of seasonal allergies or in a focus of viral infection. Duration — up to 21 days.

Pediatric Dosage (Nasal Drops): From 3 years of age — 1 drop 2 times a day, course up to 5 days. From 6 years of age — 2 drops 2 times a day. Under pediatrician supervision.

Contraindications (Nasal Drops): Individual hypersensitivity, atrophic rhinitis. Data on safety during pregnancy and lactation have not been registered.

Side Effects (Nasal Drops): Mucosal irritation, short-term tingling, sneezing. With overdose — dryness of the mucosa, increased edema.

Adjustment for Patient Body Weight: For patients with weight less than 30 kg — halving the dosage. Correction is not required for body weight over 60 kg.

Preparation Method (Nasal Drops): For 100 grams of the preparation: 10 grams of dry meadowsweet extract, 90 ml of physiological saline (0.9% sodium chloride). The extract is dissolved in a sterile solution, filtered through a 0.2 µm microfilter. Poured into sterile vials with a dropper. If desired, 2 drops of lavender essential oil can be added for softening.

Storage Conditions and Shelf Life (Nasal Drops): Store in a refrigerator at a temperature from 2 to 8 degrees Celsius. Avoid direct light. Shelf life — up to 21 days. After opening — use within 7 days.

Ear Drops — Filipendula ulmaria

Indications (Ear Drops): Acute external otitis, chronic external otitis, fungal otitis, earwax plugs with inflammation, eczema of the external auditory canal.

Standard Dosage (Ear Drops): 2 drops in each auditory canal 2 times a day. Course — 5–7 days.

Enhanced Dosage (Ear Drops): 3–4 drops 3 times a day for pronounced inflammatory processes and pain syndrome. Duration — up to 5 days.

Maximum Dosage (Ear Drops): 5 drops in the auditory canal 4 times a day — no more than 3 days. Only for pronounced inflammation and pronounced edema.

Preventive Dosage (Ear Drops): 1 drop in each auditory canal once a day after swimming or during periods of increased humidity for the prevention of external otitis in predisposed patients. Course — 7 days.

Pediatric Dosage (Ear Drops): From 3 years of age — 1 drop 1–2 times a day. From 6 years of age — 2 drops. Use under medical supervision.

Contraindications (Ear Drops): Perforation of the tympanic membrane, purulent discharge from the ear, allergy to the components of the preparation. Data on contraindications during pregnancy and lactation have not been registered.

Side Effects (Ear Drops): Short-term burning, itching, feeling of ear fullness. With overdose — increased irritation of the skin of the auditory canal.

Adjustment for Patient Body Weight: Correction is not required, as it is used topically. For children under 20 kg — reduce the dosage volume by half.

Preparation Method (Ear Drops): For 100 grams of the remedy: 10 grams of dry meadowsweet extract are dissolved in 90 grams of heated coconut oil. The mixture is heated in a water bath at 35–38 degrees Celsius, thoroughly stirred until homogeneous, strained through sterile gauze and poured into dark glass vials with a pipette.

Storage Conditions and Shelf Life (Ear Drops): Store in a cool, dark place at a temperature not exceeding 20 degrees Celsius. After opening, use within 14 days. Shelf life of the closed vial — 3 months.

Ointment — Filipendula ulmaria

Indications (Ointment): Osteoarthritis, rheumatoid arthritis, trophic ulcer, varicose veins, chronic dermatosis, eczema, contact dermatitis, neurodermatitis.

Standard Dosage (Ointment): Apply a thin layer 2 times a day to affected skin areas or joints. Rub until completely absorbed. Course — 14 days.

Enhanced Dosage (Ointment): Apply 3–4 times a day for pronounced joint inflammation, for edema, pain, inflammatory eczema. Course — up to 10 days.

Maximum Dosage (Ointment): Up to 6 applications per day on limited areas (up to 25% of the body surface) for acute arthritis or exacerbation of trophic ulcers. Course — up to 5 days.

Preventive Dosage (Ointment): Once a day on the area of joints and varicose veins. Apply in courses of 10–14 days every 2 months for chronic inflammatory diseases of joints and veins, as well as in elderly patients and patients with a sedentary lifestyle.

Pediatric Dosage (Ointment): From 6 years of age — once a day on limited skin areas (up to 10×10 cm). Apply only in the presence of indications, course no more than 5 days.

Contraindications (Ointment): Individual intolerance, purulent skin lesions, active dermatomycoses. Data on contraindications during pregnancy and lactation have not been registered.

Side Effects (Ointment): Contact allergy, itching, burning, skin peeling when the dosage is exceeded or in case of individual sensitivity.

Adjustment for Patient Body Weight: For body weight less than 40 kg — reduce the application area and frequency to once a day. Correction for patients with weight over 90 kg is not required.

Preparation Method (Ointment): For 100 grams of ointment: 10 grams of dry meadowsweet extract, 20 grams of coconut oil, 50 grams of lanolin, 20 grams of beeswax. The wax and oils are melted in a water bath, the extract is added, stirred until homogeneous, cooled to 35 degrees Celsius and poured into glass jars.

Storage Conditions and Shelf Life (Ointment): Store at a temperature from 5 to 20 degrees Celsius, in a tightly closed container protected from light. Shelf life — 6 months. After opening — use within 30 days.

Cream — Filipendula ulmaria

Indications (Cream): Rosacea, atopic dermatitis, seborrheic dermatitis, allergic contact dermatitis, skin irritation after depilation, photodermatosis.

Standard Dosage (Cream): Apply a thin layer 2 times a day to affected skin areas. Do not rub in. Course — 10–14 days.

Enhanced Dosage (Cream): Up to 3 applications per day for pronounced itching, redness, and peeling. Duration of use — no more than 7 days.

Maximum Dosage (Cream): Up to 4 applications per day. Recommended for acute allergic skin reactions. Short-term — no more than 3 days.

Preventive Dosage (Cream): Once a day in the evening for a tendency to seasonal skin inflammations, photodermatosis, seborrhea. Course — 10 days, repeat every 2 months.

Pediatric Dosage (Cream): From 3 years of age — once a day in a thin layer. Apply up to 5 days in the presence of indications.

Contraindications (Cream): Allergy to components, acute weeping dermatoses, active herpes. Data on safety during pregnancy and lactation have not been registered.

Side Effects (Cream): Skin redness, itching, peeling, irritation. With overdose — increased symptoms of dermatitis.

Adjustment for Patient Body Weight: Not required for topical use. For body weight less than 30 kg — no more than one application per day.

Preparation Method (Cream): For 100 grams: 10 grams of aqueous meadowsweet extract, 15 grams of coconut oil, 10 grams of shea butter, 60 grams of emulsion base (cetearyl alcohol, glycerin, water), 5 grams of beeswax. The components are mixed at a temperature of 45 degrees Celsius until a stable emulsion is formed. Cooled to 25 degrees and packaged in tubes.

Storage Conditions and Shelf Life (Cream): Store at a temperature from 5 to 15 degrees Celsius in a tightly closed package. Shelf life — 3 months. After opening, use within 21 days.

Lotion — Filipendula ulmaria

Indications (Lotion): Seborrheic dermatitis of the scalp, moderate acne, folliculitis, inflammation of the sebaceous glands, skin irritation after shaving, acne rash, oily seborrhea.

Standard Dosage (Lotion): Apply to clean, dry skin with a cotton pad 2 times a day — morning and evening. Do not rinse off. Course of use — 14 days.

Enhanced Dosage (Lotion): Up to 3 applications per day for active pustular rashes, inflammation of hair follicles, intense oiliness of the skin. Duration — up to 10 days.

Maximum Dosage (Lotion): 4 times a day locally (on limited areas of the skin of the face or head). Use no more than 5 days consecutively for pronounced inflammations of the sebaceous zone.

Preventive Dosage (Lotion): Once a day at night. Recommended for adolescents during hormonal changes, patients with oily and problem skin. Course — 3 weeks every 2 months.

Pediatric Dosage (Lotion): From 12 years of age — once a day on limited skin areas. If necessary, can be increased to 2 times. Course — up to 7 days.

Contraindications (Lotion): Dry and sensitive skin, eczema, pronounced peeling. Data on safety during pregnancy and lactation have not been registered.

Side Effects (Lotion): Burning, redness, feeling of skin tightness. With overdose — increased dryness and peeling.

Adjustment for Patient Body Weight: Dose adjustment is not required.

Preparation Method (Lotion): For 100 grams: 10 grams of alcoholic meadowsweet extract, 85 ml of rose water, 5 ml of glycerin. Mix the components at a temperature of 20–25 degrees Celsius. Pour into bottles with a dispenser. If necessary, 0.1 g of citric acid can be added to stabilize the pH.

Storage Conditions and Shelf Life (Lotion): Store in a tightly closed bottle, at a temperature from 5 to 20 degrees Celsius, away from light sources. Shelf life — 3 months. After opening — use within 21 days.

Serum — Filipendula ulmaria

Indications (Serum): Post-acne, couperose, sensitive skin, irritation after cosmetic procedures, inflammatory elements on the face, enlarged pores, initial stage of rosacea.

Standard Dosage (Serum): Apply once a day (in the evening) 3–4 drops to cleansed facial skin. Distribute with light movements over the surface of the face, avoiding the area around the eyes. Course — 14 days.

Enhanced Dosage (Serum): 2 times a day — morning and evening — in the presence of inflammations, redness, after aggressive procedures (laser, peels). Course — up to 10 days.

Maximum Dosage (Serum): Up to 3 applications per day locally — pointwise, on areas with acute inflammation. Only for 3 days for pronounced symptoms.

Preventive Dosage (Serum): Once a day in the evening, every other day, for a month. Recommended for patients with sensitive skin, thin vascular network, in the post-peel period.

Pediatric Dosage (Serum): From 12 years of age — 1–2 drops once a day on individual areas of the face. Course — no more than 7 days.

Contraindications (Serum): Individual intolerance, weeping dermatoses, pustular infections. Data on contraindications during pregnancy and lactation have not been registered.

Side Effects (Serum): Irritation, dryness, burning, allergic reaction. With overdose — increased skin sensitivity and peeling.

Adjustment for Patient Body Weight: Dose adjustment is not required.

Preparation Method (Serum): For 100 grams: 5 grams of aqueous meadowsweet extract, 5 grams of 1% hyaluronic acid gel, 5 ml of jojoba oil, 85 ml of witch hazel hydrolate. Mix at a temperature of 20 degrees, shake until a homogeneous emulsion is formed. Pour into glass vials with a pipette.

Storage Conditions and Shelf Life (Serum): Store in a refrigerator at a temperature from 2 to 8 degrees Celsius. Protect from light. Shelf life — 2 months. After opening — use within 14 days.

Toxicity and Biosafety of Filipendula ulmaria

Filipendula ulmaria is considered a non-toxic plant with a high degree of biosafety for oral and topical use. According to experimental studies, aqueous and alcoholic extracts of meadowsweet do not cause acute toxic reactions even with multiple excess of therapeutic doses.

The LD50 value (lethal dose for 50% of experimental animals) for the aqueous extract exceeds 5000 mg/kg of body weight in mice, which is classified as a low-toxicity substance (hazard class IV). In the studies, neither lethal outcomes nor pronounced behavioral or morphological changes were noted in animals upon administration of laboratory doses. There are also no data on cumulative toxicity, mutagenicity, embryotoxicity, and carcinogenicity.

The combined data indicate high biocompatibility of meadowsweet and the absence of clinically significant side effects at standard dosages.

Reference: https://pubmed.ncbi.nlm.nih.go....

Pharmacodynamics — Filipendula ulmaria

The pharmacodynamic properties of Filipendula ulmaria are due to the content of a complex of biologically active compounds, including flavonoids (in particular derivatives of quercetin and kaempferol), phenolic carboxylic acids (mainly salicylates), tannins (hydrolyzable and condensed tannins), as well as triterpene compounds and essential oils.

The pharmacological activity of the plant is realized both at the systemic and local levels. It has been established that meadowsweet flavonoids have pronounced antioxidant activity, participating in the neutralization of reactive oxygen species and reducing oxidative stress at the level of cell membranes, mitochondria, and intracellular fluid. This contributes to the stabilization of the cytoskeleton, a decrease in lipid peroxidation, and an improvement in tissue homeostasis.

Salicylates contained in meadowsweet have a modulating effect on inflammatory mediators — mainly due to the inhibition of cyclooxygenase (in particular COX-2), which leads to a decrease in the production of prostaglandins. In addition, these substances affect the level of bradykinin and histamine, contributing to a decrease in vascular permeability and edema. This mechanism underlies the anti-inflammatory and local analgesic effect.

On the nervous system, meadowsweet has a moderate sedative and anxiolytic effect. These effects are mediated by the interaction of polyphenols and flavonoids with GABA and serotonin receptor systems, as well as modulation of calcium channels and a decrease in neuronal excitation. The effect is manifested mainly with oral administration and depends on the dosage and duration of exposure.

On the part of the immune system, immunomodulatory properties have been registered — flavonoid compounds regulate the activity of macrophages, T-cells, and pro-inflammatory cytokines, reducing the severity of hyperergic reactions and stabilizing the nonspecific links of the immune response.

Topical application of meadowsweet is accompanied by an astringent and antiseptic effect associated with the content of tannins and phenolic compounds. With topical application, meadowsweet has a bacteriostatic effect on the opportunistic microflora of the skin and mucous membranes, inhibits the growth of Staphylococcus aureus, streptococci, and fungi of the genus Candida.

On the part of the endocrine system, mild adaptogenic effects have been recorded in the laboratory, expressed in a decrease in the reactivity of the adrenal glands to stress stimuli and normalization of cortisol-dependent processes. These effects are observed mainly with prolonged use in the form of extracts and infusions.

The pharmacodynamic activity of meadowsweet is characterized by a multi-target effect: the plant simultaneously affects mediator, enzyme, receptor, and cellular targets, while the severity of the effects depends on the route of administration, the form of the preparation, and its concentration.

References:
https://pubmed.ncbi.nlm.nih.go...
https://www.sciencedirect.com/science/article/abs/pii/S0378874111007127
https://www.tandfonline.com/do...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267289

Pharmacokinetics — Filipendula ulmaria

The pharmacokinetic properties of Filipendula ulmaria are determined by the nature of its constituent substances: flavonoids, phenolic acids, tannins, and triterpenes. Their absorption and metabolism vary depending on the dosage form and route of administration.

With oral administration (powder, infusion, dry or liquid extract), the main components undergo partial absorption in the small intestine. Flavonoids and salicylates can be absorbed in the form of aglycones or glycosides after preliminary cleavage by microflora enzymes. Salicylates are actively metabolized in the liver to form phenolic and glucuronide conjugates. Some tannins are poorly absorbed and realize their pharmacological effect locally — on the gastrointestinal mucosa.

Transdermal and topical application (in the form of ointments, creams, oil infusions) provides local bioavailability — active substances act predominantly in the epidermis and dermis, exhibiting anti-inflammatory and antiseptic effects. Deep penetration is possible in the presence of base oils and emollient emulsifiers. Systemic absorption is minimal.

Through mucous membranes (rectal and vaginal administration of suppositories), both local and moderate systemic absorption are possible. Salicylates and flavonoids through the intestinal and vaginal mucosa enter the systemic bloodstream and undergo metabolism in the liver.

The nasal route involves rapid penetration through the nasal mucosa, especially in the presence of an ethanol base. Active components can have a systemic effect, bypassing primary metabolism in the liver.

The metabolism of the main substances of meadowsweet occurs predominantly in the liver — with the participation of enzyme systems of cytochrome P450, glucuronyltransferases, and sulfotransferases. The metabolic products of flavonoids and salicylates are excreted mainly in urine, partially in bile. A small amount may be excreted through the skin and lungs.

When applied through the skin and mucous membranes, interaction with the microbiota may play an auxiliary role in the degradation of polyphenolic complexes. Bioavailability in such cases is lower, but the safety profile is higher.

Dosage forms with a high degree of extraction (for example, alcohol tinctures and dry extracts) provide a more pronounced systemic effect, while forms based on whole plant raw materials are characterized by a predominantly local effect and slower absorption.

References:
https://www.ncbi.nlm.nih.gov/p...
https://www.sciencedirect.com/science/article/pii/S0753332222003273
https://pubmed.ncbi.nlm.nih.gov/25576465
https://www.tandfonline.com/do...

Mechanisms of Action and Scientific Rationale — Filipendula ulmaria

The pharmacological activity of Filipendula ulmaria is realized through a multi-level interaction of the compounds contained in the plant with enzyme, receptor, and cellular targets. The most studied are flavonoids (mainly kaempferol and quercetin), salicylates, tannins, triterpenoids, and phenolic acids.

One of the key mechanisms of action is the inhibition of the enzyme cyclooxygenase-2 (COX-2), responsible for the synthesis of prostaglandins — mediators of the inflammatory reaction. This suppression leads to a decrease in the expression of pro-inflammatory signals, such as prostaglandin E2 (PGE2), and, accordingly, to a decrease in vascular permeability, edema, and pain response. In addition, there are data on the inhibition of the lipoxygenase pathway (LOX), which contributes to a decrease in the level of leukotrienes and additionally reduces inflammatory activity.

Meadowsweet flavonoids exhibit a pronounced antioxidant effect associated with the inactivation of superoxide anion radicals and hydroxyl radicals, inhibition of lipid peroxidation, and activation of the glutathione peroxidase system. These processes stabilize cell membranes and prevent oxidative tissue damage. Along with this, an effect on the NF-κB and MAPK signaling cascades has been shown, which explains the immunomodulatory and anti-inflammatory potential of the plant.

Separate studies demonstrate the ability of the active components of Filipendula ulmaria to modulate the expression of pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, by suppressing the activity of the nuclear factor NF-κB in macrophages. This confirms the participation of the plant in the regulation of the innate immune response and cellular inflammation. Activation of anti-inflammatory cytokines, such as IL-10, has also been described, which indicates a balanced effect with respect to immune regulation.

Data on neurotropic activity indicate the possibility of an indirect effect on the receptor systems of the central nervous system — in particular, the gamma-aminobutyric acid (GABA) and serotonergic systems. These effects are mediated by flavonoids, which have structural similarity to the ligand sites of these receptors, and are expressed in anxiolytic and sedative manifestations.

Salicylates and phenolic acids contained in the plant also have antiseptic and bacteriostatic properties. The mechanism is realized through a violation of the permeability of bacterial cell membranes and inhibition of bacterial enzymes, which leads to the suppression of growth and reproduction of pathogens. This is confirmed by in vitro results on strains of Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pyogenes.

Additional data indicate the participation of the components of Filipendula ulmaria in the inhibition of hyaluronidase activity, an enzyme that promotes the destruction of connective tissue. This explains the astringent and capillary-protective effect of the plant. A decrease in the expression of adhesion molecules on the endothelium, such as ICAM-1, has also been recorded, which may reduce the migration of leukocytes into inflamed tissues.

Thus, the action of Filipendula ulmaria is realized through complex modulation of inflammatory and antioxidant cascades, effects on enzyme systems (COX, LOX, hyaluronidase), regulation of the cytokine profile, bacteriostatic activity, and influence on neurotransmitter mechanisms.

References:
https://pubmed.ncbi.nlm.nih.gov/30102973
https://www.sciencedirect.com/science/article/abs/pii/S0378874111007127
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267289
https://www.tandfonline.com/do...
https://link.springer.com/article/10.1007/s11418-019-01350-6

Synergy — Filipendula ulmaria

The pharmacological synergy of Filipendula ulmaria with other plant and natural substances has been confirmed by a number of in vitro and in vivo studies indicating potentiating, additive, and modulating effects with combined use.

One of the most documented directions of synergy is the combination with plants rich in flavonoids, including Achillea millefolium, Matricaria chamomilla, and Calendula officinalis. At the same time, an enhancement of antioxidant activity is observed due to the cumulative capture of free radicals, restoration of the glutathione system, and stabilization of membranes. This is confirmed by data from models of induced oxidative stress, where combinations demonstrated a more pronounced decrease in malondialdehyde levels compared to monoextracts.

The synergistic anti-inflammatory effect of Filipendula ulmaria is manifested in combination with Salix alba and Harpagophytum procumbens. These combinations are characterized by additive inhibition of cyclooxygenase and lipoxygenase, a decrease in the levels of prostaglandins and leukotrienes, which contributes to a more pronounced suppression of inflammatory mediators. In experiments on rats, such combinations demonstrated a decrease in MPO and TNF-α activity, which confirms the systemic anti-inflammatory mechanism.

A protective synergy has also been described in combination with adaptogens such as Eleutherococcus senticosus and Rhodiola rosea. In these combinations, a more stable regulation of the hypothalamic-pituitary-adrenal axis, normalization of cortisol levels, and increased resistance to stress effects are noted. The effect is realized through modulation of JAK/STAT and MAPK signaling pathways.

In dermatological and cosmetic formulations, Filipendula ulmaria demonstrates synergy with Hamamelis virginiana and Aloe vera. This interaction is associated with the potentiation of antiseptic, astringent, and anti-irritant properties. Phenolic compounds of Filipendula improve the permeability of the skin barrier for other active substances, and tannin components stabilize the stratum corneum of the epidermis.

In addition, a functional complementation of antibacterial activity is observed in combination with essential oils of Melaleuca alternifolia and Thymus vulgaris. In vitro studies showed a pronounced suppression of the growth of S. aureus and E. coli in combined compositions compared to each of the components separately, which may be due to a multi-target effect on bacterial enzyme systems and membranes.

Thus, Filipendula ulmaria exhibits synergy with a wide range of natural remedies, realizing it through a combined effect on inflammatory, oxidative, neuroendocrine, and microbial mechanisms.

References:
https://pubmed.ncbi.nlm.nih.go...
https://www.sciencedirect.com/science/article/abs/pii/S0378874116300669
https://link.springer.com/article/10.1007/s11418-019-01350-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267289
https://www.tandfonline.com/do...

Geography of Use and Traditional Medicine — Filipendula ulmaria

Filipendula ulmaria has long been used in the traditional phytotherapy of the peoples of Europe, especially in its northern, western, and central parts. The plant was most widespread in Britain, Scandinavia, Germany, Poland, the Czech Republic, as well as in Russia, where it was known under the names "таволга," "медовик," "болотник," and "волжанка." In English herbalism, Filipendula ulmaria was revered as a sacred plant of the druids and was included in collections of druidic drinks that had ritual significance. According to the records of Gerald of Wales (12th century), meadowsweet was part of funeral incense among the Celts.

From the 15th century, the plant is mentioned in European phytotherapeutic manuscripts as an important remedy used in the form of decoctions and infusions. In the German tradition, it was used for wraps, baths, and steam inhalations. In the Scandinavian regions, meadowsweet decoction was used for washing the body after childbirth, as well as in the form of an infused honey drink — mead, endowed with a protective and cleansing function. In Slavic villages, meadowsweet herb was placed at the head of infants to "drive out an evil dream," and houses were fumigated with it during epidemics.

In Rus, Filipendula ulmaria was considered a plant of protection, used in conspiracies and rituals associated with cleansing the home and body from "evil charms." In some regions, the herb was burned on coals as a smoking mixture, especially during long transitions (relocations, funerals, weddings), considering it a guide between worlds.

In Irish and Welsh culture, meadowsweet was valued as the "queen of the meadows," associated with the goddess Brigid. The flowers of the plant were collected on the day of the summer solstice, believing that they absorb the power of the sun and give clarity to thoughts and spirit. Similar practices took place among the Balts, where the plant was called "zolnaya trava" and was used in cleansing bath rituals, as well as in "conspiracy water" during rituals of purification after childbirth or before a wedding.

In some regions of the Carpathians and Western Ukraine, meadowsweet was used as a "women's herb," adding it to bath brooms and infusions used for washing before fertility rituals. Among the Finno-Ugric peoples of the Volga region, the plant was also used as part of complex multicomponent smoking collections during sacrifices and rituals of the hunter's return from the forest.

In Tibetan medicine, despite the limited distribution of Filipendula ulmaria as a taxon, plants similar in action were used in complexes regulating phlegm and wind, and European monastic schools (in particular, the Benedictine traditions) adapted meadowsweet infusions as part of the monastic recipe of tonic elixirs.

Thus, meadowsweet has a rich ethnocultural history of use, covering an extensive area of Eurasia, including the traditions of Western European, Slavic, and Finno-Ugric peoples. It was used not only in domestic medicine but also in ritual, ceremonial, and protective contexts.