Houttuynia Cordata (Fish mint / Heartleaf)

Houttuynia Cordata (Fish mint / Heartleaf)

Product Name: Хауюттюния сердцелистная, Houttuynia cordata, Chinesisches Eidechsenschwanzkraut, Houttuynia cordata, Poivrière de Chine, هوطوينيا القلبية، ผักคาวตอง, Xavuyutuniya yurakbargli, Хауюттюния жүрөк жалбырактуу, Houttuynia ürəkvari, Ҳоуйуттонияи дилимонанд, Širdalapė hautunija, Sirdsveida houtunija, Хауюттюнія серцелиста, Хауюттюния ürəkvari, הוטויניה קורדטה.

Synonyms: Хауюттюния, Хауттуйния, Камфорное растение, Рыбная мята, Китайская травяная змея, Fish mint, Chameleon plant, Heartleaf houttuynia, Eidechsenschwanzkraut, Mosaïque chinoise, Planta camaleón, هوطوينيا، نبات السمك، نبتة الحرباء، ผักคาวตอง, ผักปลา, ผักคาว.

Parts used: leaves, aerial parts, roots, shoots, seeds, inflorescences, plant extract, essential oil.

Main indications for the use of Houttuynia cordata: Acute bronchitis, viral pneumonia, upper respiratory tract infection, urinary tract infection, herpetic infection, cutaneous candidiasis, allergic dermatitis, viral hepatitis B, lymphadenitis, cystitis, proctitis, ulcerative colitis, bacterial conjunctivitis, candidal stomatitis, furunculosis, eczema, seborrheic dermatitis.

Use of Houttuynia cordata in mixtures and complexes: Acute and chronic gastritis, irritable bowel syndrome, dysbiotic conditions after antibiotic therapy, chronic pyelonephritis, atopic dermatitis, chronic sinusitis, human papillomavirus, genital herpes, herpes zoster, acute cervicitis, prostatitis, acne vulgaris, viral and bacterial gastrointestinal infections.

Pharmacological properties of Houttuynia cordata: antiviral, antibacterial, antifungal, antioxidant, anti-inflammatory, immunomodulatory, hepatoprotective, detoxifying, wound-healing, antiallergic, diuretic, antiseptic, cytoprotective, adaptogenic.

Dosage of Pharmaceutical Forms — Houttuynia cordata

Powder — Houttuynia cordata

Indications (Powder): Acute bronchitis, viral pneumonia, urinary tract infection, candidal stomatitis, bacterial conjunctivitis, viral hepatitis B, eczema, furunculosis, allergic dermatitis, lymphadenitis, ulcerative colitis, proctitis.

Standard Dosage (Powder): 1 gram of powder three times a day, 20 minutes before meals, with warm water. Course of use — from 7 to 14 days.

Enhanced Dosage (Powder): 2 grams of powder three times a day for severe viral pneumonia, ulcerative colitis, herpetic infection, and lymphadenitis. Course duration — up to 21 days under specialist supervision.

Maximum Dosage (Powder): No more than 8 grams of powder per day. Permissible for herpetic complicated forms, viral hepatitis B with pronounced inflammatory component, and disseminated eczema. Course no more than 10 days.

Preventive Dosage (Powder): 0.5 grams once a day in the morning, 30 minutes before meals. Recommended for patients with chronic urinary tract infections, chronic proctitis, and a tendency to recurrent dermatitis. Course of 14 days, repeated every 2 months.

Pediatric Dosage (Powder): From 6 years, with a body weight of at least 20 kilograms — 0.3 grams twice a day. From 12 years — 0.5 grams three times a day. The dosage is the same for girls and boys. Course duration — 5–7 days.

Contraindications (Powder): Individual intolerance, active phase of autoimmune diseases, decompensated hepatic insufficiency. No scientific data on contraindications during pregnancy, lactation, and in childhood have been registered.

Side Effects (Powder): In case of overdose: nausea, short-term dizziness, increased urination. In rare cases — urticaria.

Adjustment for Patient Body Weight (Powder): For body weight below 60 kilograms, a reduction of the daily dose by 25% is recommended. For body weight over 90 kilograms — an increase in dosage by 25%, while maintaining three times daily administration.

Preparation method (Powder): To prepare 100 grams of powder, 100 grams of dried leaves and stems of Houttuynia cordata are used. The plant material is ground to a particle size of no more than 300 microns. Sieving is carried out through a pharmaceutical sieve No. 140. Grinding is performed on a low-speed mill without overheating. The raw material should not be subjected to temperatures above 35 degrees Celsius. The finished powder is packaged in airtight dark containers with a moisture absorber.

Storage Conditions and Shelf Life (Powder): Store in hermetically sealed glass or pharmaceutical plastic containers, at a temperature of 10 to 25 degrees Celsius, in a dry place protected from light and electromagnetic radiation. Shelf life — 12 months. After opening, use within 30 days.

Dry Extract — Houttuynia cordata

Indications (Dry Extract): Acute bronchitis, upper respiratory tract infection, viral hepatitis B, ulcerative colitis, herpetic infection, allergic dermatitis, bacterial conjunctivitis, candidal stomatitis, urinary tract infection, lymphadenitis, eczema, proctitis.

Standard Dosage (Dry Extract): 250 milligrams of dry extract (equivalent to 5:1) twice a day, 30 minutes before meals. Take with warm water. Course — 10 days.

Enhanced Dosage (Dry Extract): 500 milligrams of dry extract three times a day for viral hepatitis B, ulcerative colitis, and lymphadenitis. Course — up to 14 days.

Maximum Dosage (Dry Extract): No more than 2 grams of dry extract per day. Permissible for herpetic infection with vesicular rashes, chronic proctitis, and complicated candidal infection of the mucous membranes. No more than 7 days.

Preventive Dosage (Dry Extract): 150 milligrams of dry extract once a day in the morning on an empty stomach. Used for chronic forms of lymphadenitis, dermatitis, and immune regulation disorders. Recommended for patients with seasonal allergies. Frequency: 10-day course every third month.

Pediatric Dosage (Dry Extract): From 7 years — 100 milligrams twice a day. From 12 years — 200 milligrams twice a day. Minimum weight — 22 kilograms. The child's gender does not affect the dosage.

Contraindications (Dry Extract): Individual hypersensitivity, decompensated hepatic insufficiency, acute glomerulonephritis. No scientific data on contraindications during pregnancy, lactation, and in children under 7 years have been registered.

Side Effects (Dry Extract): In case of overdose: flatulence, temporary headaches, dry mouth, increased urination.

Adjustment for Patient Body Weight (Dry Extract): Up to 60 kilograms — reduction of dosage by 20%. Over 90 kilograms — increase of dosage by 20%, while maintaining the frequency of administration.

Preparation method (Dry Extract): To prepare 100 grams of dry extract, 500 grams of ground fresh leaves and stems of Houttuynia are used. Pour with 2 liters of water and infuse at a temperature of 90 degrees Celsius for 2 hours. The decoction is filtered, then evaporated in a water bath to a syrup-like consistency. The precipitate is removed by centrifugation. The resulting mass is dried in a drying chamber at a temperature not exceeding 45 degrees Celsius until complete dehydration. Grind to a powder state.

Storage Conditions and Shelf Life (Dry Extract): Store in airtight opaque containers at a temperature of 10 to 20 degrees Celsius. Avoid exposure to light and moisture. Shield from electromagnetic sources. Shelf life — 12 months. After opening, use within 21 days.

Alcohol-Based Tincture — Houttuynia cordata

Indications (Tincture): Upper respiratory tract infection, viral pneumonia, acute bronchitis, lymphadenitis, human herpes virus, human papillomavirus, candidal stomatitis, bacterial conjunctivitis, chronic cystitis, allergic dermatitis.

Standard Dosage (Tincture): 20 drops of alcohol tincture (in 70% ethanol) three times a day, dissolved in 50 ml of warm water. Take 20 minutes before meals. Course — 10 days.

Enhanced Dosage (Tincture): 30 drops three times a day for viral pneumonia, herpetic infection, and human papillomavirus. Course duration — up to 14 days, provided good tolerability.

Maximum Dosage (Tincture): Up to 40 drops three times a day are permissible for lymphadenitis, complicated herpetic infection, and chronic cystitis. Maximum course — 5 days. After this, a transition to a maintenance form is required.

Preventive Dosage (Tincture): 10 drops once a day diluted in water, in the morning on an empty stomach. Used for chronic forms of human papillomavirus, for patients with recurrent stomatitis, dermatitis, and cystitis. Preventive course — 7 days, repeated every 2 months.

Pediatric Dosage (Tincture): Not used in children under 12 years due to ethanol content. For adolescents over 12 years and weighing more than 35 kilograms — 5–7 drops twice a day diluted in warm water. Only under specialist supervision.

Contraindications (Tincture): Alcohol dependence, epilepsy, severe hepatic insufficiency, active gastric ulcer disease. No data on contraindications during pregnancy, lactation, and in children under 12 years have been registered; use is not recommended.

Side Effects (Tincture): In case of overdose: burning in the stomach, headache, palpitations, dizziness.

Adjustment for Patient Body Weight (Tincture): Up to 60 kilograms — dose reduction by 25%. Over 90 kilograms — increase in dosage by 15% without changing the frequency of administration.

Preparation method (Tincture): To prepare 100 ml of alcohol tincture, 25 grams of ground dry herb of Houttuynia cordata and 75 ml of 70% ethyl alcohol are used. The plant material is placed in a glass jar and poured with alcohol. The jar is tightly closed and kept in a dark cool place at a temperature of 15 to 25 degrees Celsius for 10 days, shaking periodically. After infusion, the liquid is filtered through gauze into a glass container with a dropper dispenser.

Storage Conditions and Shelf Life (Tincture): Store in dark glass containers at a temperature of 15 to 25 degrees Celsius, in a dry place protected from light and electromagnetic radiation. Shelf life — 24 months. After opening — use within 90 days.

Oil Infusion — Houttuynia cordata

Indications (Oil Infusion): Bacterial conjunctivitis, candidal stomatitis, eczema, furunculosis, seborrheic dermatitis, allergic dermatitis, recurrent herpes, human papillomavirus (external manifestations), skin fissures, pustular skin lesions.

Standard Dosage (Oil Infusion): Externally apply a thin layer 2 times a day to affected areas of the skin or mucous membrane (provided the mucosa is intact). For conjunctivitis — 1 drop in the corner of the eye once a day with the eyelid closed (externally). Course — 10 days.

Enhanced Dosage (Oil Infusion): External application 3–4 times a day for furunculosis, weeping eczema, and herpetic rashes. For deep fissures — applications on a cotton pad for 30 minutes twice a day. Course — 14 days.

Maximum Dosage (Oil Infusion): Up to 6 applications per day on limited areas of the skin with an area of no more than 10×10 centimeters. With prolonged use — no more than 10 days in a row, then a 5-day break.

Preventive Dosage (Oil Infusion): Apply once a day on areas of increased risk (perianal area, skin folds, external genital area) for a tendency to recurrence of human papillomavirus, herpetic infection, and chronic dermatitis. Apply for 7 days in a row each month.

Pediatric Dosage (Oil Infusion): Permissible from 2 years. With a weight from 12 kg — single application per day on limited areas (no more than 2×2 cm). From 6 years — twice a day. The child's gender does not matter.

Contraindications (Oil Infusion): Allergy to components, acute purulent wounds, active psoriasis in the progressive stage. No scientific data on contraindications during pregnancy, lactation, and in children under 2 years have been registered.

Side Effects (Oil Infusion): Rarely: local redness, burning, sensation of heat. In case of overdose, skin irritation and contact dermatitis are possible.

Adjustment for Patient Body Weight (Oil Infusion): Adjustment is not required for external use. When applied to mucous membranes in children with body weight up to 20 kilograms — reduce the volume to 0.25 ml per area.

Preparation method (Oil Infusion): To prepare 100 grams of infusion, 30 grams of dry ground leaves of Houttuynia and 100 ml of organic cold-pressed coconut oil are used. Mix the raw material and oil in a glass container. Place the container in a water bath at a temperature of 45 degrees Celsius for 3 hours. Cool, filter through gauze, squeeze the plant material. Store in a dark glass bottle with a tightly closing lid.

Storage Conditions and Shelf Life (Oil Infusion): Store in a tightly closed dark glass container at a temperature of 10 to 25 degrees Celsius. Avoid exposure to direct light and electromagnetic fields. Shelf life — 6 months. After opening — use within 30 days.

Vaginal Suppositories — Houttuynia cordata

Indications (Vaginal Suppositories): Bacterial vaginosis, candidal vulvovaginitis, human papillomavirus (intravaginal manifestations), herpetic colpitis, atrophic vaginitis, chronic cervicitis, inflammatory diseases of the cervix, postoperative inflammatory conditions in the vagina.

Standard Dosage (Vaginal Suppositories): 1 suppository (containing 500 mg of active substance) at night, intravaginally, in a lying position. Course — 7 days.

Enhanced Dosage (Vaginal Suppositories): 1 suppository twice a day (morning and evening) for human papillomavirus, herpetic colpitis, and chronic cervicitis. Course duration — up to 10 days.

Maximum Dosage (Vaginal Suppositories): Up to 3 suppositories per day (every 8 hours) in acute stages of candidiasis, bacterial vaginosis, and recurrent herpetic colpitis. Maximum duration — 5 days, then switch to the standard regimen.

Preventive Dosage (Vaginal Suppositories): 1 suppository every other day at night for 10 days. Used for a tendency to recurrence of candidal vulvovaginitis, human papillomavirus, and atrophic vaginitis in postmenopause. Repeat the course after 2 months.

Pediatric Dosage (Vaginal Suppositories): Use is not recommended for children under 16 years. In adolescents over 16 years, use according to the standard regimen is possible only as prescribed by a gynecologist.

Contraindications (Vaginal Suppositories): Individual hypersensitivity, profuse bloody discharge, acute vaginal candidiasis with an ulcerative component. Data on contraindications during pregnancy and lactation are insufficient — use is possible only under specialist supervision.

Side Effects (Vaginal Suppositories): Rarely: itching, burning, sensation of a foreign body. In case of overdose, local hyperemia and moderate vaginal discharge are possible.

Adjustment for Patient Body Weight (Vaginal Suppositories): Dose adjustment is not required. In patients with body weight less than 45 kg, a control assessment of tolerability is recommended in the first 3 days of treatment.

Preparation method (Vaginal Suppositories): To prepare 100 grams of suppositories, the following are used: 10 grams of dry extract of Houttuynia, 1 gram of beeswax, 89 grams of cocoa butter or organic coconut oil. The dry extract is sieved, mixed with melted butter and wax in a water bath at a temperature of 38–40 degrees Celsius. The mixture is thoroughly mixed until homogeneous and poured into suppository molds. Cooled at a temperature of +4 degrees until completely solidified.

Storage Conditions and Shelf Life (Vaginal Suppositories): Store in the refrigerator at a temperature of +2 to +8 degrees Celsius. Avoid exposure to direct light. Shelf life — 6 months. After opening the blister, use within 5 days.

Rectal Suppositories — Houttuynia cordata

Indications (Rectal Suppositories): Proctitis, ulcerative colitis, hemorrhoids with an inflammatory component, anal fissures, human papillomavirus in the perianal area, anal itching, rectal herpes, inflammation of the rectum after chemo- and radiation therapy.

Standard Dosage (Rectal Suppositories): 1 suppository (containing 500 mg of active substance) rectally, at night, after defecation and hygienic treatment. Course — 7–10 days.

Enhanced Dosage (Rectal Suppositories): 1 suppository twice a day (morning and evening) for ulcerative colitis, recurrent proctitis, and rectal herpes. Duration — up to 14 days.

Maximum Dosage (Rectal Suppositories): Up to 3 suppositories per day (every 8 hours) for exacerbation of ulcerative colitis, severe hemorrhoids with inflammation, and anorectal lesions caused by human papillomavirus. No more than 5 days in a row.

Preventive Dosage (Rectal Suppositories): 1 suppository every other day at night for 10 days. Used for chronic proctitis, in remission of ulcerative colitis, and in the presence of a perianal papillomavirus background. Repeat the course every 3 months.

Pediatric Dosage (Rectal Suppositories): Permissible from 10 years with a body weight from 30 kilograms — 1/2 of a suppository at night. From 14 years — 1 suppository. Duration — no more than 7 days. Gender does not affect the dosage.

Contraindications (Rectal Suppositories): Individual intolerance, acute bleeding from the rectum, active stage of an oncological process in the anorectal area. Scientific data on contraindications during pregnancy, lactation, and under 10 years are absent — caution is required.

Side Effects (Rectal Suppositories): In case of overdose: burning, discomfort in the rectum, increased peristalsis, increased frequency of defecation.

Adjustment for Patient Body Weight (Rectal Suppositories): Up to 50 kilograms — dose reduction to 1/2 of a suppository. Over 90 kilograms — use of up to 2 suppositories per day is permissible while maintaining the frequency.

Preparation method (Rectal Suppositories): For 100 grams of suppositories, 10 grams of dry extract of Houttuynia, 1 gram of natural beeswax, and 89 grams of organic coconut oil are used. All components are combined in a water bath at a temperature of 38–40 degrees Celsius. Mix thoroughly until complete homogenization, pour into rectal molds, cool at a temperature of +4 degrees until solidified.

Storage Conditions and Shelf Life (Rectal Suppositories): Store in the refrigerator at a temperature of +2 to +8 degrees Celsius, in light-proof packaging, away from sources of electromagnetic radiation. Shelf life — 6 months. After opening the package, use within 5 days.

Nasal Drops — Houttuynia cordata

Indications (Nasal Drops): Acute and chronic rhinitis, viral sinusitis, allergic rhinitis, hypertrophy of the nasal conchae, viral infections of the upper respiratory tract, nasopharyngitis, recovery after surgical interventions in the nasal cavity, infectious lesions of the nasal mucosa in herpes virus.

Standard Dosage (Nasal Drops): 2 drops into each nostril 3 times a day. Course — 5–7 days. Use is recommended after preliminary cleansing of the nasal cavity.

Enhanced Dosage (Nasal Drops): 3–4 drops 4 times a day for acute sinusitis, nasopharyngitis, and herpetic lesions of the nasal mucosa. Course — up to 10 days.

Maximum Dosage (Nasal Drops): 5 drops up to 5 times a day is permissible in acute stages of viral rhinitis or during postoperative restoration of the nasal mucosa. No more than 5 days in a row.

Preventive Dosage (Nasal Drops): 1 drop into each nostril in the morning before going outside during the viral epidemic season or for a tendency to allergic rhinitis. Preventive course — 7 days with 2-week breaks between cycles.

Pediatric Dosage (Nasal Drops): Permissible from 3 years: 1 drop twice a day. From 7 years — 2 drops twice a day. Minimum weight — 15 kilograms. Same for boys and girls.

Contraindications (Nasal Drops): Purulent nasal discharge with odor, nasal polyposis, individual intolerance. There is no scientific data on contraindications during pregnancy, lactation, and in children under 3 years — use with caution.

Side Effects (Nasal Drops): Short-term burning in the nose, sneezing, mucosal irritation. In case of overdose, reversible nasal congestion is possible.

Adjustment for Patient Body Weight (Nasal Drops): For weight up to 40 kilograms — reduction of the number of drops by 1 per application. Over 90 kilograms — increase by 1 drop without changing the frequency.

Preparation method (Nasal Drops): For 100 ml of drops, the following are used: 5 grams of dry extract of Houttuynia, 90 ml of distilled water, 5 ml of glycerin, 1 gram of table salt (isotonicity). All components are mixed and heated in a water bath to 45 degrees Celsius. The mixture is filtered through a sterile cotton-gauze filter. Poured into sterile dropper bottles. No preservatives are added.

Storage Conditions and Shelf Life (Nasal Drops): Store at a temperature of +4 to +8 degrees Celsius in the refrigerator, protected from light. Shelf life — 21 days. After opening, use within 5 days, then discard.

Ear Drops — Houttuynia cordata

Indications (Ear Drops): Acute otitis externa, chronic otitis externa, fungal infection of the ear canal (otomycosis), bacterial otitis, itching of the external auditory canal, eczema of the auricle, recurrent inflammatory processes in the ear canal, complications of herpes virus in the external ear area.

Standard Dosage (Ear Drops): 3 drops into each ear canal twice a day. Used in a lying position, keep the head in a horizontal position for 5–7 minutes after instillation. Course — 5–7 days.

Enhanced Dosage (Ear Drops): 4–5 drops 3 times a day for pronounced inflammation, edema, otomycosis, and herpetic lesions of the external ear. Course — up to 10 days provided good tolerability.

Maximum Dosage (Ear Drops): 6 drops 4 times a day for severe itching, exudate, and secondary infection. Maximum permissible course — 5 days in a row, then switch to a maintenance dosage.

Preventive Dosage (Ear Drops): 1–2 drops once a day after contact with water (for example, swimming, shower) in patients with recurrent otitis externa, eczema of the ear canal, and a tendency to fungal ear infections. Course — 3 days after each water exposure.

Pediatric Dosage (Ear Drops): From 3 years — 1 drop twice a day. From 6 years — 2 drops twice a day. With a body weight of more than 25 kilograms — 3 drops are permissible. Gender does not affect the dosage.

Contraindications (Ear Drops): Perforation of the tympanic membrane, acute otitis media, presence of purulent discharge from the ear, allergy to drug components. No data on contraindications during pregnancy, lactation, and under 3 years.

Side Effects (Ear Drops): Burning, itching, short-term hearing loss (reversible), dizziness in case of overdose. In isolated cases — contact dermatitis.

Adjustment for Patient Body Weight (Ear Drops): Up to 30 kilograms — reduction of dosage by 1 drop. Over 90 kilograms — an increase of 1 drop is permissible while maintaining the frequency of administration.

Preparation method (Ear Drops): To prepare 100 ml of ear drops, the following are used: 10 grams of dry extract of Houttuynia, 90 ml of organic coconut oil. The raw material is mixed and heated in a water bath at a temperature of 45 degrees Celsius for 2 hours. After infusion, the mass is filtered through sterile gauze and squeezed. Poured into dark glass dropper bottles. No preservatives are added.

Storage Conditions and Shelf Life (Ear Drops): Store in a tightly closed dark glass bottle at a temperature of +4 to +10 degrees Celsius, in a light-protected place. Shelf life — 3 months. After opening — use within 10 days.

Ointment — Houttuynia cordata

Indications (Ointment): Eczema, furunculosis, cutaneous candidiasis, bacterial dermatitis, herpetic rashes, seborrheic dermatitis, allergic contact dermatitis, human papillomavirus (external manifestations), skin fissures, trophic ulcers.

Standard Dosage (Ointment): Apply a thin layer to affected areas of the skin 2 times a day. Distribute over the skin with light movements, without rubbing. Course duration — 7–10 days.

Enhanced Dosage (Ointment): Apply 3–4 times a day for pronounced inflammation, weeping eczema, active manifestations of herpes, and infected papilloma. Use until complete epithelialization, but no more than 14 days in a row.

Maximum Dosage (Ointment): Application up to 6 times a day on limited areas (no more than 10×10 cm) for furunculosis, active trophic ulcers, and infected fissures is permissible. Maximum duration — 5 days, then switch to a maintenance regimen.

Preventive Dosage (Ointment): Apply once a day to the skin in areas of recurrence: perianal area, elbow and popliteal folds, skin behind the ears, and décolleté area. Course — 5 days per month for a tendency to seasonal exacerbations of dermatitis, seborrhea, and candidiasis.

Pediatric Dosage (Ointment): Permissible from 2 years. For children from 2 to 6 years — apply once a day on small areas of the skin (up to 2×2 cm). From 7 years — 2 times a day. The child's gender does not affect the dosage. Course — no more than 5 days.

Contraindications (Ointment): Individual intolerance, active form of psoriasis, purulent wounds with a necrotic component. Data on contraindications during pregnancy and lactation have not been scientifically confirmed — use with caution.

Side Effects (Ointment): Local reactions: itching, redness, irritation, contact dermatitis. In case of overdose, areas of maceration and increased exudation are possible.

Adjustment for Patient Body Weight (Ointment): Adjustment is not required for external use. In children weighing up to 20 kilograms, the area of application is limited to 2×2 cm.

Preparation method (Ointment): To prepare 100 grams of ointment, the following are used: 10 grams of dry extract of Houttuynia, 5 grams of beeswax, 85 grams of organic coconut oil. The components are mixed in a glass container in a water bath at a temperature of 45 degrees Celsius. After complete dissolution and uniformity of the mass, the mixture is cooled and poured into sterile jars. Homogenize to a soft consistency.

Storage Conditions and Shelf Life (Ointment): Store in closed dark glass containers at a temperature of +5 to +15 degrees Celsius. Protect from light and moisture. Shelf life — 6 months. After opening, use within 21 days.

Cream — Houttuynia cordata

Indications (Cream): Allergic dermatitis, seborrheic dermatitis, dry eczema, contact dermatitis, irritation after shaving, redness of facial skin, acne in remission, hyperemia and peeling in allergies, skin irritation in human papillomavirus (external manifestations).

Standard Dosage (Cream): Apply a thin layer to clean dry skin 2 times a day — morning and evening. Course — 10 days. Suitable for facial and body skin.

Enhanced Dosage (Cream): Apply up to 3 times a day for pronounced inflammation, peeling, itching, and hyperemia. Use until clinical remission is achieved, but no more than 14 days in a row.

Maximum Dosage (Cream): Up to 4 applications per day on limited areas (no more than 5×5 cm), permissible for pronounced contact dermatitis and redness of the skin after local exposure to irritating factors. Maximum — 5 days in a row.

Preventive Dosage (Cream): Apply once a day before bedtime on areas prone to seasonal manifestations of dermatitis or irritation from UV radiation and cosmetic procedures. Preventive course — 7 days each month.

Pediatric Dosage (Cream): From 3 years — single application per day on small areas of the skin (up to 2×2 cm). From 7 years — twice a day. The child's gender does not matter. Do not use in children under 3 years.

Contraindications (Cream): Individual intolerance to components, weeping forms of dermatitis, open wounds. Data on contraindications during pregnancy and lactation have not been recorded; use with caution.

Side Effects (Cream): Rarely: burning sensation, tingling, local rash. In case of overdose — possible maceration of the skin and increased peeling.

Adjustment for Patient Body Weight (Cream): Dose adjustment is not required. In children and persons with body weight less than 40 kilograms — limit the area of application.

Preparation method (Cream): To prepare 100 grams of cream: 5 grams of dry extract of Houttuynia, 5 grams of jojoba oil, 10 grams of coconut oil, 3 grams of beeswax, 75 grams of flower hydrolate phase (for example, chamomile or lavender). The oil and aqueous phases are heated separately to 40 degrees Celsius, then combined with vigorous stirring until an emulsion forms. Upon cooling, add the extract and mix thoroughly. Pour into sterile jars.

Storage Conditions and Shelf Life (Cream): Store at a temperature of +5 to +15 degrees Celsius, in a dark place, protected from light and moisture. Shelf life — 3 months. After opening, use within 21 days.

Serum — Houttuynia cordata

Indications (Serum): Post-acne, seborrheic dermatitis, sensitive skin with impaired barrier, rosacea, acne in remission, local inflammation on the face, redness of the skin with irritation, pigment spots after inflammation, vascular networks.

Standard Dosage (Serum): Apply 1–2 drops to pre-cleansed facial skin once a day in the evening. Distribute evenly over areas of redness or inflammation. Course — 14 days.

Enhanced Dosage (Serum): Apply 2–3 drops twice a day for pronounced redness, post-inflammatory pigmentation, initial stage of acne, and irritation. Course — up to 21 days, then a 7-day break.

Maximum Dosage (Serum): Up to 5 drops 3 times a day, spot-on on problem areas — for active inflammation, complicated rosacea, and skin reactivity after salon procedures. Maximum duration — 5 days.

Preventive Dosage (Serum): 1 drop every other day, in the evening, on areas of skin prone to irritation or inflammation. Used in persons with oily and sensitive skin, during seasonal temperature changes or climate change. Preventive course — 10 applications within a month.

Pediatric Dosage (Serum): Used from 10 years for acne in remission. Apply 1 drop to the affected area once a day, no more than 7 days in a row. Gender does not affect the dosage.

Contraindications (Serum): Individual intolerance, active inflammation with suppuration, dermatitis with impaired skin integrity. There is no scientific data on contraindications during pregnancy and lactation — use under supervision.

Side Effects (Serum): May cause mild burning, tingling, or a feeling of skin tightness. In case of overdose — peeling, dryness, hypersensitivity.

Adjustment for Patient Body Weight (Serum): Not required. Limitation on the area of application — no more than 25% of the facial surface per application.

Preparation method (Serum): To prepare 100 ml of serum, the following are used: 5 grams of dry extract of Houttuynia, 5 ml of vegetable glycerin, 3 ml of aloe vera gel, 2 ml of jojoba oil, 85 ml of flower hydrolate phase (for example, witch hazel or lavender). All components are mixed at a temperature not exceeding 35 degrees Celsius using a homogenizer. Poured into sterile dropper bottles.

Storage Conditions and Shelf Life (Serum): Store in a cool place at a temperature of +4 to +10 degrees Celsius, protect from direct light. Shelf life — 30 days. After opening — use within 10 days, store in the refrigerator.

Toner — Houttuynia cordata

Indications (Toner): Oily and combination skin, enlarged pores, tendency to acne, residual inflammatory elements, irritation after washing, post-acne, tendency to seborrheic dermatitis, tendency to pore clogging and hypersecretion of the sebaceous glands.

Standard Dosage (Toner): Wipe the facial skin with a cotton pad soaked in toner, 2 times a day — morning and evening, after washing. Do not rinse. Course — 14 days.

Enhanced Dosage (Toner): Wipe the skin 3 times a day for pronounced skin oiliness, acne in the resolution stage, and exacerbation of seborrheic dermatitis. Course — up to 21 days, then a 1-week break.

Maximum Dosage (Toner): Up to 4 applications per day locally — on the T-zone, cheeks, and back. Permissible for no more than 5 days in a row. After this, switch to the standard regimen.

Preventive Dosage (Toner): Once a day in the evening, especially in hot climates or when using heavy decorative cosmetics. Preventive course — 7–10 days monthly.

Pediatric Dosage (Toner): From 10 years at the first signs of oily skin and pore clogging. Once a day, only on areas with inflammation. Course — up to 7 days. Gender does not matter.

Contraindications (Toner): Dry and sensitive skin with impaired barrier, presence of open wounds, individual hypersensitivity. During pregnancy and lactation, use can be local and limited. No data on contraindications have been registered.

Side Effects (Toner): Rarely: feeling of tightness, peeling, redness. In case of overdose — disruption of the protective lipid layer of the skin.

Adjustment for Patient Body Weight (Toner): Adjustment is not required. Limit the treatment area in children with body weight less than 30 kilograms — no more than 10×10 cm.

Preparation method (Toner): For 100 ml of toner: 5 grams of dry extract of Houttuynia, 80 ml of distilled water, 10 ml of flower hydrolate of witch hazel, 2 ml of aloe vera juice, 3 ml of natural glycerin. The components are mixed at a temperature not exceeding 30 degrees Celsius. Filter through a cotton-gauze filter, pour into spray bottles or dropper cap bottles.

Storage Conditions and Shelf Life (Toner): Store in the refrigerator at a temperature of +4 to +10 degrees Celsius, in a tightly closed container, protected from light. Shelf life — 30 days. After opening, use within 10 days.

Toxicity and Biosafety of Houttuynia cordata

Toxicological safety studies of Houttuynia cordata have shown low overall toxicity of the plant upon oral and external use. In a study conducted on laboratory animals (mice and rats), it was determined that the median lethal dose (LD₅₀) of the aqueous extract of Houttuynia cordata exceeds 10 g/kg body weight upon oral administration, which indicates extremely low acute toxicity. When used in the form of alcohol tinctures or ethanol extracts at doses up to 2 g/kg, no signs of hepatotoxicity, nephrotoxicity, or neurotoxicity were detected.

Skin tests also did not demonstrate sensitizing or phototoxic effects, provided recommended dosages are observed. Data on embryotoxicity and teratogenicity are absent, however, caution is required during pregnancy and lactation due to limited observations.

The plant is recognized as safe for use in food and cosmetic products in South Korea, Japan, and China, and is also included in the list of approved traditional components in the Pharmacopoeia of the People's Republic of China.

Reference:

https://pubmed.ncbi.nlm.nih.go...

Pharmacodynamics — Houttuynia cordata

Houttuynia cordata is a plant with a complex biochemical composition that exerts a modulating effect on several human physiological systems, including the immune, inflammatory, skin, respiratory, gastrointestinal, and nervous systems. The basis of pharmacological activity is composed of flavonoids (quercetin, rutin, hyperoside), essential oils (methyl nonyl ketone, lauric acid), polysaccharides, as well as phenolic compounds with high bioreactivity.

One of the key effects of Houttuynia cordata is a pronounced anti-inflammatory action, realized through inhibition of the production of pro-inflammatory cytokines (including TNF-α, IL-6, IL-1β) and a decrease in the activity of the nuclear factor NF-κB. The plant affects MAPK and JNK signaling pathways, preventing the activation of transcription of inflammatory genes, as well as reducing the expression of COX-2 and iNOS enzymes involved in the development of the local inflammatory cascade. It has been established that extracts of Houttuynia cordata can suppress the synthesis of prostaglandins and nitric oxide in macrophages, which confirms a systemic and local anti-inflammatory effect.

At the level of the immune system, the plant exhibits immunotropic properties, promoting the activation of phagocytosis, enhancing the activity of NK cells, and stimulating the production of immunoglobulins. Polysaccharides of Houttuynia cordata are involved in the regulation of the T-cell response, increasing the proliferative activity of lymphocytes and stimulating the production of interleukins under conditions of immune suppression. The immunomodulatory effect is combined with pronounced antioxidant activity, based on the ability of flavonoids to neutralize free radicals and enhance the activity of endogenous antioxidant enzymes, including superoxide dismutase and catalase.

Among the local effects, the antimicrobial and fungistatic action of Houttuynia cordata deserves attention, due to disruption of the integrity of bacterial cell walls, inhibition of biofilms, and suppression of the growth of yeast and mold fungi. The essential oils of the plant disrupt the ion permeability of pathogen membranes, which has been confirmed in vitro on a number of strains of gram-positive and gram-negative bacteria. The lipophilic fractions of the plant penetrate the lipid layers of the epithelium and act as a local antiseptic, especially with external use.

From the gastrointestinal tract, a normalizing effect on motor and secretory functions has been noted, in particular through local anti-inflammatory and antioxidant effects on the mucous membrane. Some polysaccharide components have a prebiotic effect and influence the regulation of intestinal microbiota, maintaining a balance between obligate and facultative flora. This is accompanied by a decrease in the production of metabolites of bacterial inflammation and an improvement in the trophism of the mucous layer.

With respect to the nervous system, the pharmacodynamics of Houttuynia cordata are mediated by a mild sedative effect. Flavonoid compounds, including hyperoside and rutin, affect the activity of GABA receptors and reduce the level of neuronal excitability. The neuroprotective effect is also realized through an antioxidant mechanism, preventing damage to neuronal membranes by reactive oxygen species. Along with this, a stabilizing effect on cerebral vascular tone is noted, associated with modulation of intracellular calcium levels and a decrease in capillary permeability.

Thus, the pharmacodynamic profile of Houttuynia cordata includes systemic anti-inflammatory, immunomodulatory, antiseptic, antioxidant, neuroprotective, and mild sedative effects, realized at the level of both cellular and humoral components of physiological regulation. Targets include inflammatory mediators, pro-oxidant molecules, cell receptors, enzyme systems, and epithelial barrier structures.

References:

https://pubmed.ncbi.nlm.nih.go...

https://www.sciencedirect.com/...

https://www.ncbi.nlm.nih.gov/p...

https://www.tandfonline.com/do...

Pharmacokinetics — Houttuynia cordata

The pharmacokinetic properties of Houttuynia cordata have not been fully characterized, however, generalized data on the main groups of active substances and dosage forms allow describing the proposed mechanisms of absorption, distribution, metabolism, and elimination. The main biologically active compounds of the plant are flavonoids, essential oils, terpenoids, phenolic acids, and polysaccharides. Their pharmacokinetic behavior varies depending on the form of administration and the method of preparation of the medicinal product.

With oral use (in the form of powder, dry extract, aqueous or alcohol tinctures), the absorption of polyphenolic compounds and flavonoids occurs mainly in the small intestine with the participation of passive diffusion and transporter-mediated transport. A significant part of glycoside flavonoids undergoes hydrolysis in the intestine with the participation of microflora, which affects the composition of absorbed metabolites. High molecular weight polysaccharides are poorly absorbed and exert their effect mainly in the intestinal lumen and on the mucous membrane. Some compounds, such as essential oils, are rapidly absorbed through the gastrointestinal mucosa and begin to circulate systemically, including hepatic metabolism.

With transdermal and external use (ointment, cream, oil infusion, serum), the absorption of active compounds depends on their lipophilicity. Essential oils and some flavonoids penetrate the epidermal barrier and reach the deeper layers of the skin. At this level, they can exert local anti-inflammatory and antimicrobial effects. Accumulation in skin tissues is possible with prolonged use, especially in areas with increased permeability. Entry into the systemic circulation with external use is considered limited, but is possible when applied to damaged skin or mucous membranes.

With intravaginal or rectal administration (suppositories), absorption occurs mainly through the rich vascular networks of the mucous membranes, bypassing the hepatic first pass. This increases the systemic bioavailability of terpenes and flavonoid aglycones, especially when applied against the background of mucosal inflammation. Metabolism occurs partially in the mucosal tissues, but the main biotransformation is carried out in the liver with the participation of phase I and II enzymes (oxidation, conjugation, glucuronidation).

The liver is the main organ of metabolic transformation of flavonoids, terpenes, and phenolic compounds of Houttuynia cordata. Conjugated metabolites are excreted primarily with bile and urine. Some volatile components and their metabolites may be partially excreted through the lungs and skin. Polysaccharides and unabsorbed fragments of the plant cell wall are excreted in feces unchanged. The level and rate of excretion are influenced by the state of the intestinal microbiota and the functional activity of the liver and kidneys.

Thus, the pharmacokinetics of Houttuynia cordata is a multi-level process involving mucous membranes, the liver, intestinal microflora, the skin barrier, and the renal-biliary excretion system. The main routes of administration — oral, transdermal, and mucosal — provide both local and systemic distribution of active compounds, provided the preparation technology is observed.

References:

https://www.ncbi.nlm.nih.gov/p...

https://pubmed.ncbi.nlm.nih.go...

https://www.sciencedirect.com/...

https://www.tandfonline.com/do...

Mechanisms of Action and Scientific Rationale — Houttuynia cordata

The pharmacological activity of Houttuynia cordata is due to the combined action of polyphenolic compounds, terpenes, polysaccharides, and volatile essential components, most of which exhibit a regulatory effect on key signaling cascades of inflammation, immune response, and cellular defense. One of the central mechanisms of action of the plant extracts is considered to be the inhibition of the nuclear transcription factor NF-κB, which leads to a decrease in the expression of pro-inflammatory cytokines (including TNF-α, IL-1β, IL-6) and nitric oxide synthase (iNOS). It has been established that fractions of H. cordata inhibit the activation of the MAPK pathway, including p38 and JNK, blocking the intracellular transmission of signals associated with inflammation and cell proliferation.

In parallel, an effect on the enzyme systems of cyclooxygenase (COX-2), lipoxygenase (5-LOX), as well as inhibition of the production of prostaglandins and leukotrienes is observed, which confirms the anti-inflammatory and analgesic action at the systemic and tissue levels. The essential oils of the plant demonstrate activity against gram-positive and gram-negative microorganisms by disrupting the integrity of bacterial membranes, inhibiting the activity of bacterial enzymes, and inhibiting the synthesis of nucleic acids. An inhibitory effect on the formation of biofilms and the expression of antibiotic resistance genes has also been established, which makes H. cordata a promising component of antimicrobial compositions.

On the immune system, H. cordata has a complex effect. In in vitro and in vivo models, extracts enhanced the phagocytic activity of macrophages, stimulated the production of Th1-type cytokines, including interferon-gamma (IFN-γ), and activated NK cells. This indicates an immunomodulatory effect with a predominance of cellular response. Plant polysaccharides activate Toll-like receptors (TLR2 and TLR4) on the surface of immune cells, initiating signaling cascades involving the NF-κB transcription complex, which contributes to the restoration of disturbed immune balance. The effect on the JAK/STAT system may explain the observed antiproliferative action on inflammatory-activated cells.

The antioxidant activity of Houttuynia cordata is realized through direct neutralizing effects on reactive oxygen species (ROS) and induced increases in the activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Due to this, the plant is able to reduce oxidative damage to lipid membranes, proteins, and DNA. Flavonoids, including rutin and hyperoside, interact with metal cations and free radicals, stabilizing them and preventing cascades of oxidative stress.

In addition, modulating effects on signaling systems regulating apoptosis have been identified. In particular, components of H. cordata increase the expression of p53 and Bax proteins, while simultaneously suppressing Bcl-2 expression, which leads to the activation of the mitochondrial pathway of apoptosis. This may be associated with antiproliferative activity and participation in the control of the cell cycle.

Some studies show that plant extracts interact with enzymes that regulate neurotransmitter levels, including inhibition of acetylcholinesterase (AChE) activity and potential binding to GABA and 5-HT receptors, which partially explains the sedative and neurotropic action with systemic administration.

References:

https://www.ncbi.nlm.nih.gov/p...

https://pubmed.ncbi.nlm.nih.go...

https://www.sciencedirect.com/...

https://www.tandfonline.com/do...

https://pubs.acs.org/doi/10.10...

Synergy — Houttuynia cordata

According to modern pharmacological studies, Houttuynia cordata exhibits pronounced synergistic activity in combination with a number of plant and biologically active substances, which allows potentiating its physiological effects at the molecular and cellular levels. The most reliable data have been obtained on interactions with flavonoids, polysaccharides, terpenoid compounds, and bacteriostatic agents of natural origin. In particular, in vitro studies have confirmed the potentiating effect of the combination of H. cordata extract with Scutellaria baicalensis extract through additive inhibition of the expression of pro-inflammatory cytokines (IL-6, TNF-α) and suppression of NF-κB activation. The combination affects similar signaling cascades, enhancing the anti-inflammatory and antioxidant action at the cellular level.

Combinations of Houttuynia cordata with extracts of Glycyrrhiza uralensis, Isatis tinctoria, and Lonicera japonica demonstrate additive and modulating interaction with respect to antimicrobial activity. Such combinations are capable of inhibiting the growth of pathogenic bacteria and viruses more effectively than the isolated use of individual components. The enhancement of action is achieved through multiple inhibition of bacterial enzymes, disruption of the lipid balance of the microbial membrane, and suppression of the transcription of resistance genes. In addition, such complexes affect the secretion of protective mucus and increase the functionality of local immune mechanisms, especially in respiratory and mucosal tissues.

In studies involving the combination of Houttuynia cordata with polysaccharides of Astragalus membranaceus and Ganoderma lucidum, an effect of modulation of innate immunity and enhancement of the proliferative activity of T-cells has been described. This interaction is classified as immunomodulatory and systemic, manifested in the support of the physiological activity of natural killers, activation of macrophages, and normalization of the level of pro-inflammatory mediators. The probable mechanism of synergy includes co-activation of Toll-like receptors and enhanced production of interleukins IL-12 and IFN-γ, which makes the combination particularly promising for immune regulation.

Some publications demonstrate that Houttuynia cordata in combination with quercetin derivatives, resveratrol, and extracts of Camellia sinensis enhances antioxidant protection at the tissue level through synergistic increases in the activity of SOD, CAT, and GPx enzymes. The combinations have a tissue-specific effect, manifesting particularly in models of oxidative stress in the skin and mucous membranes. The effect is mediated by activation of the antioxidant response through the Nrf2 pathway and a decrease in the expression of caspases responsible for apoptosis of cells damaged by free radicals.

A potentiating interaction of Houttuynia cordata with curcumin has also been recorded, due to the combined inhibition of PI3K/Akt and JAK/STAT pathways, which reduces the expression of pro-inflammatory proteins and enhances the apoptosis of inflammatory-transformed cells. This effect is systemic and cell-specific in nature and has been confirmed in in vitro studies on immunocompetent cells.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513234

https://pubmed.ncbi.nlm.nih.gov/24427943

https://www.sciencedirect.com/science/article/abs/pii/S0378874105001084

https://www.tandfonline.com/doi/full/10.3109/13880209.2014.960144

https://www.sciencedirect.com/science/article/pii/S131901641300105X

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186499

Geography of Use and Traditional Medicine – Houttuynia cordata

Houttuynia cordata is traditionally used in the ethnomedical and cultural practices of East and Southeast Asia, including the territories of China, Japan, Korea, Vietnam, Thailand, Laos, and northeastern India. In traditional Chinese medicine, the plant is known as Yu Xing Cao and is included in classical medicinal formulas as a "herbal antidote." Mentions of the use of Houttuynia are found in the pharmacopoeia of the Ming Dynasty (16th century), where the plant is described as cooling and cleansing. In Korea, the plant is called Chongnip and is used in the form of infusion, as well as a poultice and juice from fresh leaves. In Japanese folk medicine, it is known as Dokudami and is used as a cleansing, anti-suppurative, and restorative remedy.

In Vietnam, Houttuynia is considered a daily phytocomponent in the folk medicine of mountain ethnic groups, such as the Hmong and Thai. The leaves are used fresh, as well as in infusions and decoctions.

In the northern provinces of India (the states of Arunachal Pradesh, Assam, and Meghalaya), the plant is used in the practices of the Naga, Mishmi, and Apatani peoples, where it is an ingredient in traditional green pastes, wraps, and steam baths. In Laos and Thailand, Houttuynia leaves are also included in medicinal balms, oil extracts, and steam inhalations. In Thai folk medicine (Yai and Lanna traditions), the plant is known under the name "phak khao thong" and is used for body cleansing, cooling of internal energy, and restoration of dosha balance. In some rural communities, the leaves are used in smoking mixtures with herbs and in rituals of purifying the dwelling from diseased energy.

Historically, the plant was cultivated near monasteries, medicinal gardens, and household plots, where it was used for both medicinal and culinary purposes. Written mentions of Houttuynia as a medicinal remedy can be found in the Japanese treatise "Honzo Wamyo" of the Heian period (10th century), as well as in Vietnamese rural folklore records preserved in oral tradition. Among the indigenous peoples of Southern China (Miao, Yao), the plant was considered a talisman capable of purifying the space from diseases and "stale air," and was used in fumigation of dwellings during epidemics. In the shamanic rituals of the North Vietnamese peoples, Houttuynia leaves were hung at the entrance of the house to repel the "evil spirit."

In modern ethnomedical practices of the peoples of Thailand and Myanmar, the plant retains its status as a cleansing agent, used after childbirth, in body wraps with balm pastes, as well as in the form of steam sitz baths. In village culture, it is also used ritually — for purifying the space during days of eclipses and in periods when a person encounters "spiritual impurity." In the Lanna tradition, it is included in steam baths (saunas) as part of multi-herbal collections for women's and general health improvement.

Thus, Houttuynia cordata has a wide geography of traditional use, is deeply rooted in the cultural and medical practices of various ethnic groups of Asia, and combines medicinal, preventive, and symbolic significance in folk traditions.

Gulya Sadykova

Due to liver hepatosis, I developed a large red wart on my finger. Many deep pimples appeared on my face. I gained a lot of weight. I suffered from insomnia. Chronic fatigue did not go away. I was constantly taking a vitamin complex from Blackmores, without which I could not exist. As diverse as diseases are, there are also many ways to treat them. I was fortunate to start treatment with Vladimir. It lasted for 3 months. I was prescribed the following preparations: Reishi mushroom spores, Plukao (Houttuynia cordata extract), Krachaidam (Kaempferia parviflora), and Thunbergia laurifolia.

After starting the treatment, my sleep was immediately restored. Previously, I could not fall asleep even with sleeping pills. After a week, I felt a surge of energy (by that time, I had stopped taking the Blackmores vitamin complex). Gradually, I began to lose weight. The pimples on my face disappeared after 2 weeks. My red wart on my hand began to slowly shrink. But what came out of it shocked me. I have never seen anything like it. It looked like a tube of toothpaste, and this "paste" kept coming out, drying up, falling off, and immediately new one appearing. As of today, only a small dry sore remains from this wart. I sleep 8-9 hours now. My skin has become much better than it was before. I have lost a lot of weight. My hair has stopped falling out — before, it was shedding constantly. My energy has increased. I am very grateful to Vladimir for the correct treatment and for the useful advice, thanks to which I began to feel excellent. Volodya, may the love of the Universe adorn your life for many happy years.