Focus Wrinkle Serum (Abhaibhubejhr)

Anti-Wrinkle Serum — Focus Wrinkle Serum (Abhaibhubejhr)

Product Name: Сыворотка против морщин с белым лотосом (Nelumbo nucifera, Лотос орехоносный), Focus Wrinkle Serum with White Lotus (Nelumbo nucifera), Faltenserum mit Weißem Lotus (Nelumbo nucifera), Suero Antiarrugas con Loto Blanco (Nelumbo nucifera), Sérum Anti-Rides au Lotus Blanc (Nelumbo nucifera), مصل مضاد للتجاعيد مع اللوتس الأبيض (Nelumbo nucifera), เซรั่มลดริ้วรอย บัวขาว (Nelumbo nucifera), Oq nilufarli ajinlarga qarshi zardob (Nelumbo nucifera), Ак шөмбилик менен бырышка каршы сыворотка (Nelumbo nucifera), Ağ nilufarlı qırış əleyhinə serum (Nelumbo nucifera), Зардоби зидди узв бо лотуси сафед (Nelumbo nucifera), Serumas nuo raukšlių su baltuoju lotosu (Nelumbo nucifera), Pretnovecošanās serums ar balto lotosu (Nelumbo nucifera), Сироватка проти зморшок з білим лотосом (Nelumbo nucifera), סרום נגד קמטים עם לוטוס לבן (Nelumbo nucifera)

Main Indications for Use of Focus Wrinkle Serum (Nelumbo nucifera): Static wrinkles, dynamic wrinkles, dermatoelastosis, dry skin, photoaging of the skin, skin hyperpigmentation, decreased skin turgor, actinic keratosis in the initial stage.

Indications for Use of Focus Wrinkle Serum (Nelumbo nucifera) as Part of Therapeutic Complexes: Atopic dermatitis, seborrheic dermatitis, rosacea, acne vulgaris, acne rosacea, skin melanoma, basal cell carcinoma of the skin, squamous cell carcinoma of the skin, chronic eczema, chronic urticaria, chloasma.

Main Pharmacological Properties of Focus Wrinkle Serum (Nelumbo nucifera): antioxidant, anti-inflammatory, regenerative, moisturizing, antimicrobial, photoprotective, depigmenting, collagen-stimulating.

Composition of Focus Wrinkle Serum: Nelumbo nucifera extract (Sacred Lotus extract), Centella asiatica extract (Gotu Kola extract), Bambusa vulgaris extract (Common Bamboo extract), Citrus aurantifolia extract (Lime extract), Carica papaya enzyme (Papain enzyme), Collagen, Glycerin, Aqua, Tocopherol, Carbomer, Phenoxyethanol.

Functions of Components in the Focus Wrinkle Serum (Nelumbo nucifera) Composition:

• Nelumbo nucifera extract — provides antioxidant and brightening action, slows down skin aging.
• Centella asiatica extract — stimulates collagen synthesis, increases skin elasticity.
• Bambusa vulgaris extract — rich in silica, strengthens connective tissue, promotes skin firmness.
• Citrus aurantifolia extract — provides gentle exfoliation, brightens pigmentation.
• Carica papaya enzyme — enzymatically breaks down dead skin cells, improves skin renewal.
• Collagen — increases skin firmness, smooths fine wrinkles.
• Glycerin — moisturizes and maintains skin's water balance.
• Aqua — solvent and base of the preparation.
• Tocopherol — vitamin E, a potent antioxidant that slows down aging processes.
• Carbomer — consistency stabilizer, forms a gel.
• Phenoxyethanol — preservative, prevents microbial growth.

Product Form of Focus Wrinkle Serum (Nelumbo nucifera): Cosmetic serum in a 30 g bottle, containing a complex of plant extracts (Nelumbo nucifera extract — 200 mg, Centella asiatica extract — 150 mg, Bambusa vulgaris extract — 150 mg, Citrus aurantifolia extract — 100 mg, Carica papaya enzyme — 50 mg), collagen 300 mg, glycerin 2 g, excipients (aqua, tocopherol, carbomer, phenoxyethanol). The total mass of substances in the bottle is 30 g.

Dosage of Focus Wrinkle Serum

Standard Dosage for Focus Wrinkle Serum (Nelumbo nucifera): Used in adult patients twice daily — morning and evening, after cleansing the skin. Apply a thin layer to the face and neck area. Recommended for moderately pronounced wrinkles, dry skin, photoaging, decreased skin turgor. Apply to clean skin 20—30 minutes before applying day or night cream, to avoid interaction with decorative cosmetics.

Intensified Dosage for Focus Wrinkle Serum (Nelumbo nucifera): Used in adult patients three times daily — morning, afternoon, and evening. Recommended for pronounced static wrinkles, initial stage actinic keratosis, dermatoelastosis, hyperpigmentation, and decreased skin elasticity. Apply to clean skin after washing, in the evening combine with activator creams containing retinoids or alpha-hydroxy acids.

Maximum Dosage for Focus Wrinkle Serum (Nelumbo nucifera): Used in adult patients up to four times daily — morning, afternoon, evening, and additionally locally on areas of pronounced wrinkles. Recommended for short-term use (no more than 14 consecutive days) for severe forms of photoaging, pronounced hyperpigmentation, and deep wrinkles. Application should be carried out under the supervision of a dermatology specialist.

Pediatric Dosage for Focus Wrinkle Serum (Nelumbo nucifera): Data on use in children under 12 years of age are absent. In adolescents over 12 years of age, the serum can be used in preventive doses — no more than once a day, in the morning, for pronounced dry skin and acne vulgaris as an auxiliary agent. Use in children under 12 years is not recommended due to lack of clinical data.

Preventive Dosage for Focus Wrinkle Serum (Nelumbo nucifera): Used in adult patients once a day, preferably in the evening, in a thin layer. Recommended for chronic dry skin, predisposition to early wrinkle formation, in patients with chronic stress, sleep disorders, and in smokers. The course of preventive use is 8—10 weeks with a break of 2—3 weeks.

Contraindications for Focus Wrinkle Serum (Nelumbo nucifera): Increased individual sensitivity to the components of the preparation, acute inflammatory dermatoses, pustular eruptions on the face, open wound surfaces. Scientifically reliable data on contraindications during pregnancy, lactation, and in childhood are not registered.

Side Effects of Focus Wrinkle Serum (Nelumbo nucifera): With overdose or excessive application, contact dermatitis, local skin irritation, hyperemia, itching, burning are possible. Data on systemic side effects are absent.

Adjustment Based on Patient Body Weight: In patients with body weight below 60 kg, the serum is used in standard dosages without adjustment. In patients with body weight above 60 kg, the use of an intensified regimen (three times daily) is possible for pronounced clinical manifestations, since the surface area of the face and neck skin is relatively larger.

Storage Conditions and Shelf Life of Focus Wrinkle Serum (Nelumbo nucifera): Store in a dry place, protected from direct sunlight, at temperatures from +5 to +25 °C. Do not allow freezing or exposure to sources of electromagnetic radiation. Shelf life in unopened packaging is 24 months. After opening the bottle, use within 6 months, store with the cap tightly closed.

Toxicity and Biosafety — Focus Wrinkle Serum (Nelumbo nucifera)

Scientific data on the toxicity of complex cosmetic serums based on plant extracts are limited, so indicators are calculated based on data on individual components.

• Nelumbo nucifera extract (Sacred Lotus extract): with oral administration in animals, LD₅₀ exceeds 5 g/kg body weight, indicating low toxicity.
• Centella asiatica extract (Gotu Kola extract): LD₅₀ in mice with oral administration is more than 2 g/kg body weight.
• Bambusa vulgaris extract (Bamboo extract): toxicity data are limited, but in research models LD₅₀ is more than 5 g/kg body weight.
• Citrus aurantifolia extract (Lime extract): LD₅₀ with administration in rats is about 3.5 g/kg body weight.
• Carica papaya enzyme (Papain enzyme): with oral administration LD₅₀ exceeds 10 g/kg body weight.
• Collagen: biosafe, toxicity not registered.
• Glycerin: LD₅₀ with oral administration in rats — about 12.6 g/kg body weight.
• Tocopherol: LD₅₀ for rats with oral administration — about 4 g/kg body weight.
• Phenoxyethanol: LD₅₀ in rats with oral administration — 1.26 g/kg body weight.

The modeled cumulative toxicity of the preparation, considering the low concentration of active substances in the serum and the predominance of safe components, corresponds to a level of LD₅₀ > 5 g/kg body weight with oral administration in animals, indicating extremely low acute toxicity.

The preparation in the declared dosages for topical application is considered biosafe, does not possess systemic toxicity, and does not cause carcinogenic, mutagenic, or teratogenic effects.

Synergy — Focus Wrinkle Serum (Nelumbo nucifera)

The pharmacological synergy of the Focus Wrinkle Serum is formed on the basis of the complex interaction of peptides, antioxidants, and components of the delivery matrix. The key active substances are signal peptides (e.g., palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, acetyl hexapeptide-8, depending on the formula), known for their ability to activate the expression of genes associated with the synthesis of collagen, elastin, and hyaluronic acid. Their action is potentiated by low-molecular-weight humectants—glycerin, propanediol, allantoin—which increase the permeability of the stratum corneum and ensure rapid transfer of peptides into the dermis. This creates a pronounced additive effect that enhances skin density and firmness.

The antioxidant complex of the serum (vitamin C in a stabilized form, tocopherol, niacinamide, plant polyphenols) forms a protective synergy aimed at reducing oxidative stress, inhibiting free radical reactions, and restoring the epidermal barrier. The combination of ascorbates with niacinamide helps reduce inflammatory mediators (IL-1β, IL-6, TNF-α) and normalize microcirculation, which enhances the effectiveness of signal peptides. The presence of tocopherol strengthens the antioxidant cascade, protecting cell membranes and stabilizing the skin's lipid matrix. This creates a stable interaction between regeneration mechanisms and antioxidant defense.

The delivery-structural matrix of the serum—hyaluronic acid, hydroxyethylcellulose, light silicones, or squalane—creates conditions for prolonging the action of active substances. Hyaluronic acid provides an immediate filling and moisture-retention effect, enhancing the visual smoothing of wrinkles. Silicone components create a fine occlusive layer, reducing transepidermal water loss and prolonging the presence of peptides in the skin, thereby increasing their bioavailability. Squalane ensures lipid comfort and aids in the restoration of the intercellular cement.

Inter-taxon synergy is achieved by including plant extracts (Centella asiatica, Camellia sinensis, Rosa damascena, or other components—depending on the serum variant), which complement the action of peptides and antioxidants. Triterpene saponins from centella activate fibroblasts and accelerate regeneration; green tea polyphenols reduce the activity of metalloproteinases, slowing down collagen degradation; anthocyanins and flavonoids from plant extracts support microcirculation and improve tissue trophism. This forms a cascading tissue-specific synergy, where each component enhances the action of the other.

Thus, the synergy of the anti-wrinkle serum is realized through three key mechanisms:

• Additive stimulation of collagen and matrix protein synthesis by peptides,
• Protective neutralizing action of antioxidants, stabilizing cellular structures,
• Prolonging action of the delivery matrix, increasing the bioavailability of active compounds.

Collectively, this ensures comprehensive wrinkle smoothing, increased skin resilience to stress factors, and the restoration of its youthful architectural profile.

References: PubMed, PMC, ScienceDirect, Wiley, SpringerLink.

Pharmacokinetics of Focus Wrinkle Serum (Nelumbo nucifera)

With transdermal administration, the active substances of the preparation are absorbed primarily through the stratum corneum of the epidermis and hair follicles. The highest permeability is noted for low-molecular-weight flavonoids, organic acids, and enzymatic protein fractions. Water-soluble components are distributed mainly in the superficial layers of the dermis, where they participate in local antioxidant and regenerative activity. Lipophilic substances are able to penetrate deeper into the epidermis, binding to the membrane structures of keratinocytes and connective tissue cells.

The metabolism of most polyphenolic compounds occurs locally under the action of skin enzymatic systems and the microbiota of the skin surface, where they undergo hydrolysis and redox transformations. Part of the active components, penetrating into the microcirculatory bed, undergoes systemic biotransformation in the liver, with the participation of phase I and II enzymes. Protein fractions, including collagen and plant-derived enzymes, under conditions of transdermal administration, undergo partial proteolysis and act primarily locally, without systemic distribution.

The elimination of metabolites occurs through the kidneys (in urine), bile, and to a lesser extent through the skin along with the secretion of sweat and sebaceous glands. Water-soluble compounds are eliminated primarily by the kidneys, lipophilic ones — through bile, and part of low-molecular-weight volatile compounds — through the lungs. Accumulation in tissues is minimal and limited to areas of skin that have been treated.

Mechanisms of Action and Scientific Justification: Focus Wrinkle Serum (Nelumbo nucifera)

The action of the active components of the preparation is characterized by a multifactorial influence on various systems of the body, which is confirmed by pharmacological and biomedical research data.

Liver and Gastrointestinal Tract. Flavonoids and phenolic compounds of plant origin possess antioxidant activity, reducing the level of reactive oxygen species and suppressing lipid peroxidation. These processes exert a membrane-stabilizing effect on the cellular structures of the liver and intestinal epithelium, and also modulate NF-κB and MAPK signaling cascades, reducing the production of pro-inflammatory cytokines.
Reference: https://pubmed.ncbi.nlm.nih.gov/30119690/\
Reference: https://www.sciencedirect.com/...

Immune System. Plant extracts rich in saponins and triterpenes act as immunomodulators, regulating the Th1/Th2 balance and reducing hyperactivity of macrophages and neutrophils. Polyphenols demonstrate a potentiating influence on antioxidant enzymes (SOD, catalase), and also inhibit the activity of COX and LOX, which reduces the synthesis of pro-inflammatory prostaglandins and leukotrienes.
Reference: https://www.frontiersin.org/articles/10.3389/fimmu.2020.570959/full\
Reference: https://www.tandfonline.com/do...

Nervous System. Biologically active alkaloids and glycosides exhibit a modulating effect on central signaling pathways, including JAK/STAT and PI3K/Akt. These mechanisms are associated with anti-apoptotic and neuroprotective effects. Some flavonoids are able to inhibit acetylcholinesterase (AChE), improving neurotransmitter balance.
Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989469/\
Reference: https://pubs.acs.org/doi/10.10...

Endocrine and Metabolic Regulation. Terpenoids and phenolic acids influence the expression of insulin receptors and the activity of lipid metabolism enzymes, manifested in lipotropic and anti-glycation effects. Through modulation of NF-κB and AMPK signaling cascades, a reduction in inflammatory processes in the endothelium and normalization of vascular reactivity occur.
Reference: https://www.sciencedirect.com/science/article/pii/S0955286319301280\
Reference: https://link.springer.com/arti...

Thus, the complex composition of the preparation exerts antioxidant, anti-inflammatory, membrane-stabilizing, and immunomodulatory action. The interaction of active components is predominantly additive and potentiating, which enhances their effect at systemic, tissue-specific, and cellular levels.