​Angelica sinensis (Chinese Angelica)

Angelica sinensis (Chinese Angelica)

Product Name: Дудник китайский, Angelica sinensis, Chinesische Engelwurz, Angélica china, Angélique chinoise, دانغ كاي, ตังกุย

Synonyms: дудник китайский, донг квай, женский женьшень, корень жизни, китайская ангелика; dong quai, Chinese angelica, female ginseng; chinesische Engelwurz, Frauen-Ginseng; angélica china, ginseng femenino; angélique chinoise, ginseng de la femme; دانغ كاي, الجنسنغ الأنثوي; ตังกุย, โสมสตรี

Main Indications for the Use of Angelica sinensis: Primary dysmenorrhea, climacteric syndrome, premenstrual syndrome, anovulatory infertility, iron deficiency anemia, chronic pelvic pain syndrome, knee osteoarthritis, cerebrovascular insufficiency, coronary heart disease, neurocirculatory dystonia, posthemorrhagic anemia, hypoestrogenism, neurasthenia, chronic fatigue syndrome.

Use of Angelica sinensis in Mixtures and Complexes: Uterine fibroids, adenomyosis, endometriosis, cervical erosion, cervical dysplasia, chronic endometritis, chronic cystitis, osteoporosis, hypothyroidism, fibromyalgia, autoimmune thyroiditis, varicose veins, atherosclerosis, chronic pancreatitis, hepatitis C, mixed-type dementia.

Pharmacological Properties of Angelica sinensis: Estrogen-like, anti-inflammatory, antioxidant, analgesic, spasmolytic, immunomodulatory, anti-anemic, neuroprotective, fibrinolytic, cardiotonic, hepatoprotective, vasodilatory, antiplatelet, nootropic, antithrombotic.

Dosage of Pharmaceutical Forms — Angelica sinensis

Powder — Angelica sinensis

Indications (Powder): Primary dysmenorrhea, climacteric syndrome, premenstrual syndrome, iron deficiency anemia, chronic pelvic pain syndrome, neurasthenia, knee osteoarthritis, hypoestrogenism, anemia of mixed genesis.

Standard Dosage (Powder): 1.5–3 grams of powder orally 2 times a day after meals, with warm water.

Enhanced Dosage (Powder): 4–5 grams of powder 2 times a day for severe hypoestrogenism, chronic anemia, pronounced dysmenorrhea, and in preparation for in vitro fertilization.

Maximum Dosage (Powder): 6 grams 2 times a day, short-term for up to 7 days, for severe anemia, uterine fibroids with hypomenstrual syndrome, and osteoarthritis with a pronounced pain component.

Preventive Dosage (Powder): 1 gram of powder once a day in the morning, for 30 days, with the course repeated after 3 months. Recommended for perimenopause, iron deficiency conditions in vegetarians, and chronic fatigue syndrome in women.

Pediatric Dosage (Powder): For girls weighing from 30 kg and over 12 years of age: 0.5 grams once a day for 7–10 days in the presence of functional menstrual cycle disorders. Use in children under 12 years of age is not recommended.

Contraindications (Powder): Pregnancy, lactation, presence of active bleeding, thrombocytopenia, hyperestrogenic conditions (e.g., hormone-dependent tumors), individual intolerance. Data on safety in children under 12 years of age have not been scientifically registered.

Side Effects (Powder): Flatulence, hypotension, photosensitivity of the skin, sleep disturbances, increased menstrual bleeding when exceeding the dosage.

Adjustment for Patient Body Weight (Powder): Patients with body weight below 60 kg are recommended to reduce the dose by 20%. Patients with body weight above 80 kg may have the dosage increased by 20–25% in the absence of contraindications.

Preparation method (Powder): To obtain 100 grams of powder, thoroughly dried roots of Chinese Angelica are used. The roots are ground to particles with a diameter of no more than 0.2 mm using a steel grinder. The process is carried out at a temperature not exceeding 40 degrees Celsius, in the shade, without access to direct light. After grinding, the powder is sifted through an 80-mesh sieve. Store in an airtight glass container.

Storage Conditions and Shelf Life (Powder): Store in a tightly closed container made of dark glass, in a dry, cool place at a temperature not exceeding 25 degrees Celsius. Avoid exposure to direct light and electromagnetic radiation. Shelf life — 12 months. After opening the package, use within 30 days.

Extract — Angelica sinensis

Indications (Extract): Primary dysmenorrhea, hypoestrogenism, iron deficiency anemia, climacteric syndrome, chronic fatigue syndrome, coronary heart disease, osteoarthritis, premenstrual syndrome, neurocirculatory dystonia.

Standard Dosage (Extract): Aqueous or hydroalcoholic extract is taken orally at 2.5 ml 2 times a day, course — 14–21 days. Extract concentration — 1:2 (for each 1 ml of extract — 2 g of initial raw material).

Enhanced Dosage (Extract): Up to 5 ml of extract 2 times a day for severe iron deficiency anemia, severe forms of dysmenorrhea, posthemorrhagic conditions, and chronic fatigue syndrome in women over 45 years.

Maximum Dosage (Extract): 7 ml 2 times a day, for no more than 10 days in a row, for severe anemia, pronounced climacteric syndrome, and preparation for hormonal therapy for infertility. Thereafter, a transition to a maintenance regimen is necessary.

Preventive Dosage (Extract): 1 ml of extract once a day in the morning, course — 21 days, then a break of 2 months. Used in perimenopausal women, for chronic fatigue, in individuals with latent iron deficiency, and in autonomic dysfunction.

Pediatric Dosage (Extract): Used from 14 years of age, with body weight from 45 kg. Dosage — 0.5 ml once a day, for 7 days for menstrual cycle dysfunction. Use under 14 years of age is not recommended due to hormone-like effects.

Contraindications (Extract): Pregnancy, active uterine bleeding, thromboembolic diseases, estrogen-dependent tumors. Data on contraindications during breastfeeding and in children under 14 years of age have not been scientifically registered.

Side Effects (Extract): Headache, irritability, lowering of blood pressure, hot flashes, increased bleeding. With overdose, insomnia and decreased blood clotting are possible.

Adjustment for Patient Body Weight (Extract): Patients with body weight less than 60 kg are recommended to reduce the dose by 25%. For weights over 80 kg, the dose may be increased by 20%, with monitoring of blood parameters.

Preparation method (Extract): To prepare 100 ml of concentrated hydroalcoholic extract, take 50 g of dry powdered root of Chinese Angelica, pour 100 ml of a mixture of purified water and 40% ethyl alcohol in a 1:1 ratio. Infuse in a sealed glass container at a temperature of 20–25 degrees Celsius in a dark place for 14 days. Then the mixture is filtered, the sediment is squeezed out, the filtrates are combined and stored in a dark bottle.

Storage Conditions and Shelf Life (Extract): Store in a tightly closed dark glass container, at a temperature of 4 to 20 degrees Celsius, in a place protected from light and EMI. Shelf life — 12 months. After opening, use within 30 days, store in the refrigerator.

Alcohol-Based Tincture — Angelica sinensis

Indications (Tincture): Hypoestrogenism, climacteric syndrome, primary dysmenorrhea, iron deficiency anemia, neurocirculatory dystonia, autonomic disorders, chronic fatigue, myalgia, atherosclerosis, hypotension.

Standard Dosage (Tincture): 15–20 drops of tincture 2 times a day 20 minutes before meals. Course of administration — 21 days, then a break of 2 weeks.

Enhanced Dosage (Tincture): 25–30 drops 2 times a day for pronounced symptoms of climacteric syndrome, intense vasomotor disorders, chronic fatigue, hypoestrogenism, and neurocirculatory dystonia with predominance of vagotonia.

Maximum Dosage (Tincture): 40 drops 2 times a day, for no more than 10 days in a row. Used for acute non-vegetative crises, severe anemia, and severe premenstrual syndrome. Thereafter, a return to the standard dosage is necessary.

Preventive Dosage (Tincture): 10 drops once a day in the morning, on an empty stomach, for 14 days. Recommended for women in perimenopause, with a tendency to hypotension, anemia, weather sensitivity, and also for patients with fatigue under stress loads.

Pediatric Dosage (Tincture): Alcoholic tincture is not recommended for children under 18 years of age due to the ethanol content and the lack of registered safety studies. Use is possible only in the form of aqueous extracts or powder from 12 years of age.

Contraindications (Tincture): Pregnancy, lactation, alcoholism, liver diseases, acute inflammatory processes in the gastrointestinal tract, epilepsy, estrogen-dependent tumors. Data on use in adolescents have not been registered.

Side Effects (Tincture): Dizziness, hypotension, sensation of heat, sweating, nausea, increased menstrual bleeding with prolonged use or exceeding the dose.

Adjustment for Patient Body Weight (Tincture): For body weight less than 60 kg — dose reduction by 15–20% (approximately 12–15 drops). For weight over 80 kg, an increase in dose by 20–25% is possible with good tolerability.

Preparation method (Tincture): To prepare 100 ml of alcoholic tincture, take 20 grams of dry powdered root of Chinese Angelica. Pour 100 ml of 70% ethyl alcohol. Infuse in dark glass in a cool place (18–22 °C) for 10 days with daily shaking. Then filter through gauze, squeeze out the remainder. Pour the resulting tincture into a dark glass bottle.

Storage Conditions and Shelf Life (Tincture): Store in a tightly closed dark glass bottle, at a temperature of 15–25 degrees Celsius, in a dark, dry place. Avoid exposure to direct sunlight and electromagnetic fields. Shelf life — 24 months. After opening, use within 60 days.

Oil Infusion — Angelica sinensis

Indications (Oil Infusion): Neuralgia, osteoarthritis, myalgia, painful menstruation, atrophic vulvitis, vaginal dryness, climacteric syndrome, skin itching, dermatitis, urticaria, psoriasis.

Standard Dosage (Oil Infusion): Topically: apply 2 times a day to the problem area (5–7 drops) with light massaging movements. Intravaginally (using tampons): 1 ml, once a day, for 7–10 days (for vulvitis or mucosal atrophy). For skin manifestations: apply locally 1–2 times a day.

Enhanced Dosage (Oil Infusion): Topically: up to 10 drops 2–3 times a day for severe joint pain, intense itching, or neurodermatitis. Intravaginally: up to 1.5 ml per day for severe dryness, hypoestrogenism, in combination with mucosal injuries.

Maximum Dosage (Oil Infusion): Topically: up to 15 drops 3 times a day — for a course of no more than 7 days. Intravaginally: up to 2 ml per day, for no more than 5 days in a row, only under specialist supervision. Used for severe mucosal atrophy and postmenopausal syndrome.

Preventive Dosage (Oil Infusion): Topically: 3–4 drops once a day in the evening on the area of joints, lower back, or neck for chronic fatigue, mild forms of arthritis, and skin dryness in perimenopausal women. Course — 21 days, repeat every 2 months.

Pediatric Dosage (Oil Infusion): Use is possible in children over 10 years only topically — no more than 2 drops once a day on limited skin areas for skin itching and dermatitis. Intravaginal use is not allowed.

Contraindications (Oil Infusion): Allergy to essential oils or plants of the Umbelliferae family, pregnancy, acute inflammatory skin processes, skin damage, hormone-dependent tumors. Data on use in children under 10 years of age and during lactation have not been registered.

Side Effects (Oil Infusion): Contact dermatitis, burning, skin hyperemia, headache when inhaling a large volume of vapor. With overdose, increased photosensitivity of the skin is possible.

Adjustment for Patient Body Weight (Oil Infusion): For body weights below 60 kg — apply no more than 3–5 drops. For body weight over 80 kg, the dosage can be increased by 25% with good tolerability.

Preparation method (Oil Infusion): To prepare 100 ml of infusion, take 20 grams of dry powdered root of Chinese Angelica and pour 100 ml of organic cold-pressed oil (sesame or almond oil is recommended). Infuse in a sealed glass container in a dark place at a temperature of 35–40 °C for 10 days. Shake daily. Then strain through cotton cloth. Squeeze out the residue. Store the finished infusion in a dark glass bottle.

Storage Conditions and Shelf Life (Oil Infusion): Store in a dark, cool place at a temperature of 5 to 20 degrees Celsius, away from direct light and electromagnetic radiation. Shelf life — 6 months. After opening, use within 30 days. Do not store in metal or transparent containers.

Vodka-Based Tincture — Angelica sinensis

Indications (Tincture): Premenstrual syndrome, autonomic dystonia, neurocirculatory hypotension, climacteric disorders, weather sensitivity, chronic fatigue, anemia, arthralgia.

Standard Dosage (Tincture): 20 drops 2 times a day before meals. Course — 21 days, then a break of at least 14 days.

Enhanced Dosage (Tincture): 30 drops 2 times a day for pronounced autonomic disorders, increased anxiety, fatigue, and hypoestrogenism. Duration — no more than 10 days, then transition to the standard regimen.

Maximum Dosage (Tincture): 40 drops 2–3 times a day, for no more than 5 days in a row. Used for pronounced vasomotor disturbances in perimenopause, unstable hemodynamics, and stress overloads.

Preventive Dosage (Tincture): 15 drops once a day in the morning, on an empty stomach, for 14 days. Repeat — every 2–3 months. Recommended for chronic fatigue, hypotension, latent anemia, and autonomic instability in women over 40.

Pediatric Dosage (Tincture): Not used in children and adolescents under 18 years of age due to the ethanol content and lack of safety data.

Contraindications (Tincture): Pregnancy, lactation, hepatic insufficiency, epilepsy, active gastritis, peptic ulcer disease, alcoholism, estrogen-dependent tumors. Data on use in children and adolescents are absent.

Side Effects (Tincture): Nausea, headache, increased menstruation, hypotension, insomnia with evening intake. When exceeding doses — CNS depression, irritability, tachycardia.

Adjustment for Patient Body Weight (Tincture): For weight less than 60 kg — the dose should be reduced to 15 drops. For weight over 80 kg — an increase of 20–25% is allowed with tolerability.

Preparation method (Tincture): To obtain 100 ml of tincture, take 25 grams of dry powdered root of Chinese Angelica, pour 100 ml of high-quality vodka (40% ethanol) in a glass container. Infuse in a dark, cool place at a temperature of 18–22 degrees Celsius for 14 days, shaking daily. Upon completion, filter the tincture, squeeze out the remainder. Store in a dark glass bottle.

Storage Conditions and Shelf Life (Tincture): Store in a dark, cool place at a temperature of 10 to 25 degrees Celsius, away from sources of light and heat. Shield from electromagnetic fields. Shelf life — 12 months. After opening the package, use within 30 days.

Aqueous Extract — Angelica sinensis

Indications (Aqueous Extract): Iron deficiency anemia, hypoestrogenism, primary dysmenorrhea, climacteric syndrome, neurocirculatory dystonia, chronic fatigue syndrome, insomnia, osteoarthritis.

Standard Dosage (Aqueous Extract): 5 ml (one teaspoon) 2 times a day 30 minutes before meals. Duration of course — 21 days.

Enhanced Dosage (Aqueous Extract): 7.5 ml 2 times a day for pronounced climacteric manifestations, secondary anemia, premenstrual pain, nocturnal tachycardia, vascular lability. Course — no more than 10 days, then — transition to the standard regimen.

Maximum Dosage (Aqueous Extract): 10 ml 2 times a day, allowed for no more than 5 days in a row. Used for severe iron deficiency anemia, pronounced vascular dystonia with hypotension, and intense spastic pelvic pain.

Preventive Dosage (Aqueous Extract): 2.5 ml once a day in the morning on an empty stomach. Course — 30 days. Recommended for perimenopausal women, with chronic fatigue, mild forms of vegetative-vascular dystonia, and a tendency to iron deficiency. Course repetition — once every 3 months.

Pediatric Dosage (Aqueous Extract): Use is allowed from 10 years of age, with body weight from 30 kg. Single dose — 1 ml once a day, course — 7–10 days. Use is possible for mild anemia, autonomic instability, and reduced performance.

Contraindications (Aqueous Extract): Pregnancy, active bleeding, tumors with hormonal activity, individual intolerance. During lactation and in children under 10 years of age — scientifically substantiated safety data have not been registered.

Side Effects (Aqueous Extract): Headache, increased menstrual bleeding, dyspepsia, skin rash, nausea. When exceeding the dosage, arterial hypotension and anxiety are possible.

Adjustment for Patient Body Weight (Aqueous Extract): Patients with body weight less than 60 kg — the dose should be reduced by 20%. For body weight over 80 kg, an upward adjustment of 15–25% is possible under specialist supervision.

Preparation method (Aqueous Extract): To prepare 100 ml of extract, take 30 grams of dry powdered root of Chinese Angelica and pour 300 ml of purified water. Heat in a water bath at a temperature of 85–90 °C for 45 minutes. Cool to 40 °C, filter through gauze. Reduce the obtained volume to 100 ml over low heat. After cooling, pour into a sterile dark glass container.

Storage Conditions and Shelf Life (Aqueous Extract): Store in the refrigerator at a temperature of 4–8 degrees Celsius, in a tightly closed glass bottle. Avoid exposure to light and electromagnetic radiation. Shelf life — 10 days. After opening, use within 72 hours.

Essential Oil — Angelica sinensis

Indications (Essential Oil): Aromatherapy for anxiety disorders, insomnia, neurovegetative dystonia, chronic stress, hormonal imbalance, tension headache, climacteric syndrome, muscle spasms, bronchial asthma (in remission phase), functional gastrointestinal disorders, flatulence, skin inflammations.

Standard Dosage (Essential Oil): For aromatherapy: 2–3 drops in an aroma lamp or on a cloth (session 20–30 minutes 1–2 times a day). For inhalations: 1–2 drops in 300 ml of hot water, inhale steam for 5–7 minutes. For topical use: 1 drop per 10 ml of carrier oil (e.g., jojoba or grape seed), apply to the skin 1–2 times a day.

Enhanced Dosage (Essential Oil): Aroma lamp: up to 5 drops for pronounced nervous exhaustion, anxiety, PMS symptoms, and climacteric hot flashes. Topically: 2 drops per 10 ml of oil for spasms, muscle pain, and skin inflammations. Course — up to 10 days, then a break of at least 7 days.

Maximum Dosage (Essential Oil): 6 drops in an aroma lamp or 3 drops per 10 ml of oil (topically), no more than 2 times a day. Only in conditions of short-term intensive therapy for no more than 5 days in a row for severe anxiety, sleep disturbances, or spasms.

Preventive Dosage (Essential Oil): Aromatherapy: 1–2 drops in an aroma diffuser once every 2 days. Topical use: 1 drop per 15 ml of carrier oil, once a day, for a course of 14 days. Recommended for a tendency to stress, chronic fatigue syndrome, weather sensitivity, and menstrual cycle instability.

Pediatric Dosage (Essential Oil): Allowed only from 12 years of age. Aromatherapy: 1 drop in an aroma lamp for 15 minutes. Topically: 0.5 drops per 20 ml of carrier oil, once a day for irritability and sleep disturbances. Inhalations are not recommended.

Contraindications (Essential Oil): Pregnancy, breastfeeding, epilepsy, individual intolerance. Contraindicated in active asthma, photodermatitis, and hypotension. In children under 12 years of age — not recommended. Scientifically confirmed safety data during pregnancy and lactation have not been registered.

Side Effects (Essential Oil): Headache, nausea, mucosal irritation, photosensitivity of the skin, dizziness. With overdose — increased anxiety, insomnia.

Adjustment for Patient Body Weight (Essential Oil): For body weight up to 60 kg — dosage is reduced by 25%. For body weight over 80 kg, an increase in dose by 20% is possible with good tolerability.

Preparation method (Essential Oil): To obtain 100 ml of essential oil, steam distillation of 5 kg of fresh Chinese Angelica root is used. The raw material is crushed, placed in a distiller, where it is exposed to steam at a temperature of 98–100 °C. The oil phase is separated from the aqueous phase and collected in a sealed dark glass container. The oil does not require additional preservatives.

Storage Conditions and Shelf Life (Essential Oil): Store in a tightly closed dark glass bottle at a temperature of 5–20 °C, away from sources of light, heat, and EMI. Shelf life — 24 months. After opening, use within 3 months.

Phytoemulsion and Cream — Angelica sinensis

Indications (Phytoemulsion and Cream): Skin dryness, irritation, age-related skin changes, dermatitis, atrophic vulvitis, premenstrual eruptions, hormone-dependent skin inflammations, eczema, psoriasis, skin hypotrophy in postmenopause.

Standard Dosage (Phytoemulsion and Cream): Apply a thin layer 2 times a day to clean skin. Area of application — face, neck, décolleté, or external genitalia (as indicated). Course — 21–28 days.

Enhanced Dosage (Phytoemulsion and Cream): 3 times a day for pronounced dryness, itching, flaking, skin irritation, and also in the case of climacteric hypoestrogenic skin atrophy. Course — up to 14 days, then transition to the standard dose.

Maximum Dosage (Phytoemulsion and Cream): Up to 4 times a day in conditions of acute inflammation, dermatitis, or fissures, only on limited skin areas. Duration — no more than 5 days. After this, a reduction in frequency to 1–2 times a day is necessary.

Preventive Dosage (Phytoemulsion and Cream): Once a day before bedtime, for a course of 14–21 days. Recommended for perimenopausal and postmenopausal women, patients with dry skin type, with weather sensitivity and stress-induced skin dryness.

Pediatric Dosage (Phytoemulsion and Cream): From 7 years — a single application per day on localized areas for neurodermatitis, eczema, and atopic dermatitis is allowed. Minimum dose — 0.2 ml per 100 cm² of skin. Use under dermatologist supervision.

Contraindications (Phytoemulsion and Cream): Allergic reactions to cream components or essential oils, acute purulent skin inflammations, active form of herpes, presence of hormone-dependent tumors. Data on safety in pregnant, lactating women, and children under 7 years of age are absent.

Side Effects (Phytoemulsion and Cream): Redness of the skin, burning, sensation of heat, allergic rashes. With excessive use — contact dermatitis, increased photosensitivity of the skin.

Adjustment for Patient Body Weight (Phytoemulsion and Cream): Not required for external use, however, patients with body weight below 50 kg and sensitive skin are recommended to start with a single application per day.

Preparation method (Phytoemulsion and Cream): To obtain 100 grams of cream: — oil infusion of Chinese Angelica — 30 g, — beeswax — 8 g, — purified water — 40 g, — vegetable glycerin — 10 g, — emulsifier (soy lecithin) — 5 g, — essential oil of Angelica — 1–2 drops, — natural preservative (rosemary extract) — 0.5 g. Melt the wax in a water bath, add the infusion and lecithin, mix thoroughly. Separately heat water with glycerin to 60 °C. Gradually introduce the aqueous phase into the oil phase, constantly stirring until a homogeneous emulsion is formed. At the end, introduce the essential oil and preservative. Package the cream in a sterile jar and cool.

Storage Conditions and Shelf Life (Phytoemulsion and Cream): Store at a temperature of 5 to 10 °C, in a dark, airtight package. Shelf life — up to 60 days. After opening, use within 21 days. Avoid exposure to direct sunlight and overheating.

Compresses and Lotions — Angelica sinensis

Indications (Compresses and Lotions): Neuralgia, myositis, arthralgia, localized edema, soft tissue inflammation, post-traumatic hematomas, trophic disorders, skin itching, furunculosis, eczema.

Standard Dosage (Compresses and Lotions): Moisten sterile gauze in an aqueous or alcoholic solution of Angelica and apply to the affected area for 20–30 minutes 1–2 times a day. Course — 5–7 days.

Enhanced Dosage (Compresses and Lotions): Use a double layer of gauze moistened with a high-concentration infusion and fix the compress for 1–1.5 hours 2 times a day for pronounced inflammation, myositis, and chronic joint pain. Course — up to 5 days, then transition to the standard dosage.

Maximum Dosage (Compresses and Lotions): Use up to 3 times a day with an exposure duration of up to 2 hours. Allowed for acute soft tissue inflammations and neuralgia, only with monitoring of skin reaction. No more than 3 days in a row.

Preventive Dosage (Compresses and Lotions): Once every 2 days, for 20 minutes, for a tendency to myalgia, rheumatoid pain, and muscle tension. Course — 7 procedures. Repeat — no earlier than 1 month later.

Pediatric Dosage (Compresses and Lotions): From 7 years. Use diluted aqueous infusion in a 1:4 ratio (1 part infusion to 4 parts boiled water). Duration — no more than 15 minutes once a day. Applicable for skin inflammations, bruises, and insect bites.

Contraindications (Compresses and Lotions): Violation of skin integrity, purulent inflammations, allergy to components, malignant neoplasms in the area of application. During pregnancy and lactation, external use is allowed only in diluted form. In children — strictly under supervision.

Side Effects (Compresses and Lotions): Local irritation, hyperemia, itching, contact dermatitis. With prolonged or intensive use — dry skin, flaking, photosensitivity.

Adjustment for Patient Body Weight (Compresses and Lotions): Not required, as the form of application is local. However, for individuals with body weight up to 50 kg and sensitive skin, it is recommended to use the aqueous infusion in diluted form.

Preparation method (Compresses and Lotions): To prepare 100 ml of solution for compress: — dry root of Chinese Angelica — 10 g, — purified water — 100 ml. Grind the root, pour boiling water over it and infuse for 30 minutes under a lid. Strain, cool to 36–38 °C. Moisten sterile gauze in the resulting infusion and apply to the desired area. The decoction can be stored for no more than 24 hours in the refrigerator.

Storage Conditions and Shelf Life (Compresses and Lotions): Store the prepared infusion in the refrigerator at a temperature of 4–8 °C for no more than 24 hours. Do not subject to repeated heating. Store dry raw materials in a tightly closed container, at a temperature of up to 25 °C, in a dry, dark place.

Lotion and Toner — Angelica sinensis

Indications (Lotion and Toner): Couperose, seborrheic dermatitis, dry skin, hormonal rashes, skin hypersensitivity in perimenopause, sluggish skin tone, acne in adulthood, itching, irritation after shaving or cleansing, post-stress skin reactivity.

Standard Dosage (Lotion and Toner): Wipe the skin with a cotton pad moistened with toner, 2 times a day (morning and evening) after washing. For oily skin — 3 times a day. Course — 14–21 days.

Enhanced Dosage (Lotion and Toner): Local application in the form of lotions on inflamed areas — 2–3 times a day for 5 minutes, for 7 days, for acne, rashes, dermatitis, and age-related oily skin.

Maximum Dosage (Lotion and Toner): Up to 4 times a day for pronounced inflammations, seborrhea, and exacerbation of hormonal rash. Only on limited skin areas, for no more than 7 days in a row, then — transition to the standard regimen.

Preventive Dosage (Lotion and Toner): Once a day, preferably in the evening, for a course of 14 days. Applicable for a tendency to stress-induced skin reactions, dryness, imbalance in perimenopause, weather-dependent skin, and vegetative-vascular disorders.

Pediatric Dosage (Lotion and Toner): Allowed from 12 years for acne and skin irritation: once a day on limited areas, in diluted form (50% of the base solution). No more than 7 days in a row.

Contraindications (Lotion and Toner): Individual intolerance, acute pustular rashes, allergy to composition components, active herpes, skin microtrauma. During pregnancy and lactation, external use is possible with good tolerability. In children under 12 years — not recommended.

Side Effects (Lotion and Toner): Redness, flaking, burning of the skin, contact dermatitis. With overdose or non-compliance with frequency — dryness, epidermal thinning, photosensitization.

Adjustment for Patient Body Weight (Lotion and Toner): Not required for external use. Patients with thin, sensitive skin and body weight less than 50 kg are recommended to start with 1 time per day and in diluted form.

Preparation method (Lotion and Toner): For 100 ml of composition: — aqueous extract of Angelica (1:2) — 50 ml, — witch hazel hydrolate — 30 ml, — sage infusion — 15 ml, — organic apple cider vinegar — 3 ml, — essential oil of Angelica — 1 drop, — grapefruit seed extract (preservative) — 1 ml. Combine all components at a temperature not exceeding 25 °C, mix until homogeneous. Pour into sterile bottles with a dispenser. Shake before use.

Storage Conditions and Shelf Life (Lotion and Toner): Store in the refrigerator at a temperature of 4–8 °C, in a sealed dark glass bottle. Shelf life — up to 30 days. After opening, use within 14 days. Avoid exposure to light and heating.

Plasters and Ointment Dressings — Angelica sinensis

Indications (Plasters and Ointment Dressings): Myalgia, arthralgia, gout, chronic osteoarthritis, muscle spasms, post-traumatic edema, trophic ulcers (in the granulation stage), neurodermatitis, psoriasis, persistent skin itching.

Standard Dosage (Plasters and Ointment Dressings): Apply an ointment dressing with Angelica to the affected area once a day for 2 hours. Course — 7–10 procedures. Coverage area — no more than 20 × 20 cm at a time.

Enhanced Dosage (Plasters and Ointment Dressings): The dressing is applied 2 times a day for 2 hours with a high concentration of active substance (up to 20% of the ointment base). Used for pronounced pain syndrome, post-traumatic edema, and nocturnal muscle spasms. Course — 5 days, then standard dosage.

Maximum Dosage (Plasters and Ointment Dressings): Ointment with a concentration of up to 30% active substance, applied 3 times a day for 1–1.5 hours. Used only on a limited area (no more than 10 × 10 cm) for acute joint inflammation and severe pain. Course — no more than 3 days.

Preventive Dosage (Plasters and Ointment Dressings): Once a week for 1 hour on the lower back, neck, or joint area in individuals with chronic fatigue, a tendency to back pain, and in the climacteric period. Course — 4–6 procedures, repeat — after 2 months.

Pediatric Dosage (Plasters and Ointment Dressings): From 10 years, application area no more than 5 × 5 cm, ointment with a concentration not exceeding 5%. Duration — 30–40 minutes once a day, no more than 5 days. Used for skin itching, myalgia, and after bruises.

Contraindications (Plasters and Ointment Dressings): Allergic reactions, individual intolerance, purulent processes, weeping dermatoses, open wounds, pregnancy. In children — only external use in diluted form.

Side Effects (Plasters and Ointment Dressings): Skin irritation, redness, itching, local hyperemia. With prolonged use or high concentration — flaking, sensitization, photodermatitis.

Adjustment for Patient Body Weight (Plasters and Ointment Dressings): Patients with body weight below 50 kg — it is recommended to use ointments of lower concentration (5–10%). Patients with weight over 80 kg are allowed to use 20% concentration.

Preparation method (Plasters and Ointment Dressings): For 100 g of ointment: — powder of Chinese Angelica root — 10–20 g, — cold-pressed sesame oil — 40 g, — beeswax — 30 g, — anhydrous lanolin — 20 g. Melt the wax in a water bath at 65–70 °C, introduce lanolin and oil, mix until homogeneous. Cool to 40 °C and gradually add the Angelica powder, stirring intensively. Package the ointment in sealed containers.

Storage Conditions and Shelf Life (Plasters and Ointment Dressings): Store at a temperature of 5 to 10 °C, in a tightly closed dark glass jar. Avoid exposure to light and heat. Shelf life — 3 months. After opening, use within 21 days.

Polysaccharide Hydrogels — Angelica sinensis

Indications (Polysaccharide Hydrogels): Atrophic dermatitis, dry skin, mucosal inflammation, first-degree burns, ulcers in the epithelialization stage, post-acne, hormonal disturbances of the skin barrier, sensitive skin, allergic dermatoses.

Standard Dosage (Polysaccharide Hydrogels): Apply a thin layer to clean skin 2 times a day (morning and evening). Area of application — face, neck, décolleté, external genitalia, vaginal vestibule mucosa (as indicated). Course — 14–21 days.

Enhanced Dosage (Polysaccharide Hydrogels): Up to 3 times a day for pronounced dryness, fissures, irritation, and in the reparative stage after burns and dermatitis. Course duration — 10–14 days, then transition to the standard dosage.

Maximum Dosage (Polysaccharide Hydrogels): 4 times a day, short-term (no more than 5 days), for acute skin reactions, allergic inflammations, and mucosal microtrauma. Application should be limited to an area of no more than 15 × 15 cm.

Preventive Dosage (Polysaccharide Hydrogels): Once a day, preferably in the evening, for 10–14 days. Recommended for perimenopausal skin dryness, sensitivity to temperature changes, post-stress skin vulnerability, and barrier function impairment.

Pediatric Dosage (Polysaccharide Hydrogels): From 7 years. Apply once a day in a thin layer to localized skin areas (face, neck, hands). Use only 1% concentration of the active substance, course — up to 5 days. Used for irritation, flaking, and itching.

Contraindications (Polysaccharide Hydrogels): Individual intolerance, pustular skin diseases, allergy to components, weeping dermatoses. During pregnancy and lactation, external use is allowed in the absence of a reaction. In children under 7 years — not recommended.

Side Effects (Polysaccharide Hydrogels): Rarely — burning, sensation of a film, contact dermatitis, allergic rashes. With overdose and frequent application — skin maceration, increased itching.

Adjustment for Patient Body Weight (Polysaccharide Hydrogels): Not required. Adjustment is determined solely by the area of application and skin sensitivity.

Preparation method (Polysaccharide Hydrogels): For 100 g of gel: — aqueous extract of Angelica (1:2) — 50 ml, — aloe vera gel (natural) — 30 g, — xanthan gum — 1.5 g, — rose hydrolate — 15 ml, — essential oil of Angelica — 1 drop, — plant-derived preservative (sage extract) — 0.5 ml. Mix the hydrolate and Angelica extract, then slowly introduce xanthan gum with stirring until thickening. Then add aloe gel, essential oil, and preservative. Mix until a homogeneous texture is obtained. Package in sealed bottles.

Storage Conditions and Shelf Life (Polysaccharide Hydrogels): Store at a temperature of 4–8 °C in a tightly closed container, protected from light and EMI. Shelf life — up to 30 days. After opening, use within 10 days. Do not allow contamination of the contents.

Complex Herbal Preparations — Angelica sinensis

Indications (Complex Herbal Preparations): Uterine fibroids, endometriosis, endometrial hypoplasia, chronic endometritis, adenomyosis, climacteric syndrome, iron deficiency anemia, autoimmune thyroiditis, neurasthenia, neurocirculatory dystonia, polycystic ovary syndrome, hypoestrogenism, persistent dysmenorrhea.

Standard Dosage (Complex Herbal Preparations): A formula of 3–5 components containing aqueous extract of Angelica in a volume of 3 ml per dose, 2 times a day before meals. Course — 21 days. Most often combined with motherwort, red brush, lady's mantle, and orthilia.

Enhanced Dosage (Complex Herbal Preparations): A formula of 6–8 components with an enhanced proportion of Angelica (up to 5 ml per dose) in combination with wintergreen, nettle, hops, and sage. Prescribed for persistent hormonal disorders, endocrine infertility, and chronic inflammation of the female genital organs. Course — 14 days, then transition to the standard regimen.

Maximum Dosage (Complex Herbal Preparations): Up to 6 ml of Angelica per dose in an intensive phytotherapy regimen (3 times a day) for severe hypoestrogenism, severe forms of anemia, and perimenopausal disorders. Maximum duration — 5 days, then — standard dose.

Preventive Dosage (Complex Herbal Preparations): 1.5 ml of Angelica in the herbal mixture once a day for 21 days. Recommended for perimenopausal women, with a tendency to decreased hemoglobin, mild hormonal dysfunctions, and stress-dependent disorders. Repeat — after 2 months.

Pediatric Dosage (Complex Herbal Preparations): Not used under 16 years. From 16 years — up to 1.5 ml of aqueous extract in the mixture once a day for 5–7 days for dysfunctional menstruation. Only by specialist prescription.

Contraindications (Complex Herbal Preparations): Hormone-dependent tumors, pregnancy, lactation, severe hyperestrogenism, thrombophlebitis, thromboembolism. Not used in children under 16 years. Scientific data on use in male phytoreglmens are absent.

Side Effects (Complex Herbal Preparations): Spotting bloody discharge, increased menstruation, dizziness, decreased blood pressure, fatigue. With overdose — insomnia, irritability.

Adjustment for Patient Body Weight (Complex Herbal Preparations): Up to 50 kg — dose reduction by 25%. From 80 kg — an increase of 20% is allowed in the formula with monitoring of general condition and hematological parameters.

Preparation method (Complex Herbal Preparations): For 100 ml of concentrated infusion: — Chinese Angelica (dry root) — 10 g, — motherwort — 10 g, — nettle — 10 g, — Rhodiola rosea — 5 g, — sage — 5 g, — red brush — 5 g, — purified water — 500 ml. Mix the raw materials, pour boiling water over them, infuse in a water bath for 30 minutes, then hold under a lid until cooling. Filter. Reduce to 100 ml. Take 25 ml 2 times a day.

Storage Conditions and Shelf Life (Complex Herbal Preparations): Store in the refrigerator at 4–8 °C in glass containers, no more than 5 days. Repeated heating is not allowed. After opening, use within 48 hours. Store dry raw materials in airtight packaging for up to 1 year.

Additives for Applications and Dressings — Angelica sinensis

Indications (Additives for Applications and Dressings): Post-traumatic edema, soft tissue bruises, spastic pain, rheumatic arthritis, inflammation of periarticular tissues, skin itching, dry skin, secondary muscle fatigue.

Standard Dosage (Additives for Applications and Dressings): Add 5–10% of Angelica powder to the base (clay, honey, oil) for applications. Apply a 0.5 cm layer to the affected area, cover with gauze and fix. Exposure time — 30–45 minutes, once a day. Course — 5–7 days.

Enhanced Dosage (Additives for Applications and Dressings): Up to 15% Angelica powder in the composition, apply 2 times a day for pronounced joint inflammation, myositis, and muscle pain after overload. Procedure duration — up to 60 minutes. Course — 5 days.

Maximum Dosage (Additives for Applications and Dressings): 20% powder in the composition, no more than 2 times a day and no more than 3 days in a row. Used for intense pain, neuralgia, and inflammation with edema. Exposure time — 60–90 minutes.

Preventive Dosage (Additives for Applications and Dressings): 5% Angelica content in clay or honey. Application once every 3 days for 30 minutes on the lower back, neck, or joint area in individuals with chronic muscle tension and perimenopausal pain syndrome. Course — 4 procedures, repeat — after 1–2 months.

Pediatric Dosage (Additives for Applications and Dressings): From 7 years — 2–3% powder in the composition, apply to a small area (up to 10 cm²) for 15–20 minutes, once a day. Course — no more than 3 days. Used for skin irritations, bruises, and after insect bites.

Contraindications (Additives for Applications and Dressings): Open wounds, purulent inflammations, hypersensitivity to the plant, oncopathology in the application area. During pregnancy and lactation — external use is allowed only in minimal concentrations. Under 7 years — do not use.

Side Effects (Additives for Applications and Dressings): Contact dermatitis, itching, flaking, local burning. With excessive concentration — skin maceration, increased itching.

Adjustment for Patient Body Weight (Additives for Applications and Dressings): For individuals up to 50 kg — concentration not more than 5%. For individuals over 80 kg — an increase to 15% is allowed, in the absence of skin reactions.

Preparation method (Additives for Applications and Dressings): For 100 g of application mass: — Angelica powder — 5–15 g (depending on the desired concentration), — white or blue clay — 50 g, — water or chamomile hydrolate — 30 ml, — sea buckthorn oil — 5 ml. Sift the clay, mix with Angelica powder. Gradually introduce the liquid phase, mix until a creamy consistency. Introduce the oil, mix. Use immediately after preparation.

Storage Conditions and Shelf Life (Additives for Applications and Dressings): Do not store the prepared mixture. Storage of the dry mixture (clay + Angelica powder) in a sealed container in a dark, dry place for up to 3 months is allowed. Add the liquid phase before use.

Toxicity and Biosafety of Angelica sinensis

Chinese Angelica demonstrates a high profile of biological safety when used orally and topically in traditional dosages. Animal studies have shown that acute administration of Angelica sinensis extract does not cause lethal outcomes at doses up to 7 g/kg body weight in rats, which corresponds to an extremely low level of toxicity. The LD₅₀ value of the aqueous extract upon intravenous administration in mice exceeds 6 g/kg, and upon oral administration, it is not reached even at 10 g/kg, indicating extremely low acute toxicity. Chronic administration of Angelica extracts for 90 days in laboratory animals (rats and mice) did not cause hematological, histopathological, or behavioral deviations. Studies have not found mutagenic or carcinogenic potential in the active components, including ferulic acid and ligustilide, within therapeutic doses. However, with prolonged use of high doses, a slight inhibition of blood clotting was observed, which requires caution in patients with hemostasis disorders. With external use (in the form of essential oil and creams), isolated cases of contact allergy have been noted. Photosensitizing effects are observed when the oil is applied to exposed skin areas followed by ultraviolet irradiation, especially in high concentrations. Data on teratogenicity or fetotoxicity in humans are insufficient; therefore, use during pregnancy is not recommended. In childhood, use is possible from 7–12 years of age in appropriate pharmaceutical forms with dosage monitoring.

Reference: https://pubmed.ncbi.nlm.nih.go...

Pharmacodynamics — Angelica sinensis

The pharmacodynamic action of Chinese Angelica is due to a complex of biologically active compounds, including organic acids, phthalides (primarily ligustilide), polysaccharides, and phytosterols. The main directions of action are the modulating effect on the neuroendocrine, vascular, immune, and skin systems. It has been established that plant components possess anti-inflammatory activity mediated by inhibition of cyclooxygenase and lipoxygenase activity, as well as a reduction in the production of pro-inflammatory cytokines. A sedative and anxiolytic effect has been recorded, probably associated with the potentiation of GABAergic transmission. Angelica substances exhibit antioxidant activity, stabilize cell membranes, and reduce lipid peroxidation. Pharmacological effects are realized both locally and systemically, depending on the form and route of administration. An interaction with glucocorticoid and estrogen receptors has been found, as well as with elements of signaling pathways controlling inflammation, cell proliferation, and vascular tone.

References: https://pubmed.ncbi.nlm.nih.go...; https://www.sciencedirect.com/...

Pharmacokinetics — Angelica sinensis

The pharmacokinetics of Chinese Angelica depends on the form of administration and the nature of the active compounds. With oral administration (powder, aqueous and alcoholic extract), the main components, including ligustilide and ferulic acid, undergo partial absorption in the small intestine. Metabolism begins with enzymatic transformation in the liver, including through enzymes of the microsomal P450 system. Metabolites are excreted primarily with bile and urine. Polysaccharide fractions are partially fermented by the intestinal microbiota with the formation of short-chain acids and bioactive derivatives capable of interacting with immunocompetent cells of the mucosa. With transdermal and local use (essential oil, ointment forms), the absorption of active substances occurs slowly, with a predominant effect in the area of application. Some of the lipophilic components penetrate into the systemic circulation and are metabolized in the liver. With inhalation administration, rapid absorption through the alveoli with the participation of pulmonary metabolism and subsequent systemic distribution is possible.

References: https://www.ncbi.nlm.nih.gov/p...; https://link.springer.com/arti...

Mechanisms of Action and Scientific Rationale — Angelica sinensis

The main mechanisms of action of Chinese Angelica are associated with its ability to modulate key links in inflammatory and neurohumoral cascades. Phthalides, in particular ligustilide, inhibit the enzymatic activity of COX-2 and 5-LOX, reducing the synthesis of pro-inflammatory prostaglandins and leukotrienes. Plant polysaccharides activate macrophages and enhance the production of cytokines IL-2 and IFN-γ, exerting an immunomodulatory effect. An effect on estrogen receptors of the α type has also been established, as well as an interaction with the signaling pathways NF-κB and PI3K/Akt, which is accompanied by an antioxidant and anti-apoptotic effect. The effect on GABA receptors has been confirmed by a number of in vitro studies, indicating neurosedative and anxiolytic potential. In addition, Angelica affects the smooth muscles of blood vessels and the uterus by blocking calcium channels, which provides a spasmolytic effect.

References: https://pubmed.ncbi.nlm.nih.go...; https://www.sciencedirect.com/...; https://www.tandfonline.com/do...

Synergy — Angelica sinensis

Scientific publications indicate a pronounced pharmacological synergy between Chinese Angelica and plants containing phytoestrogens (e.g., Cimicifuga racemosa), as well as adaptogenic and immunomodulatory compounds (Panax ginseng, Rhodiola rosea). Potentiation of the antioxidant and anti-inflammatory effect has been noted with the combined use of flavonoid-containing taxa (Ginkgo biloba, Scutellaria baicalensis), which is accompanied by an enhancement of NF-κB regulation and a reduction in oxidative stress levels. When combined with salvianic acids or saponins, a modulating effect on the microvascular bed and homeostasis is possible. The nature of the interaction is predominantly potentiating and modulating, at the level of signaling pathways and receptor complexes.

References: https://pubmed.ncbi.nlm.nih.go...;  https://www.sciencedirect.com/...

Geography of Use and Traditional Medicine — Angelica sinensis

Chinese Angelica is traditionally used in East Asian medical systems, primarily in Chinese, Korean, Japanese, and Tibetan medicine. Its historical use dates back, according to written sources, to at least the Han Dynasty era (2nd century BC — 2nd century AD), where the plant was mentioned in classical treatises on the treatment of female ailments and the regulation of the life energy "qi." In Chinese tradition, Angelica, known as "dong quai" (当归), was included in complex formulations, most often in the form of decoctions and alcoholic tinctures. Special attention was paid to its use by women, with the plant being perceived as a "blood tonic" and "body harmonizing" agent.

In Tibetan medicine, Angelica was part of complex phytocompositions used in hot oil wraps and rubbings. In a ritual context, it was used as a purifying and fragrant plant — its dried parts were burned as incense used during cleansing ceremonies and in the practice of rituals for harmonizing "wind" and "bile" — the energy principles described in Tibetan medical philosophy.

In Japan, Angelica is known as "touki" and is used within the framework of Kampo medicine, which is based on ancient Chinese medical principles. In this context, the plant was used primarily in the form of powders and aqueous extracts, as well as in food forms, including fermented herbs. The Japanese tradition emphasizes the "dispersing cold" and "calming" action of Angelica.

In Korea, Angelica was used in traditional Hanyak medicine, often in combination with other root taxa. It was prepared in the form of steam tinctures, hot water decoctions, and complex multi-component remedies. In a number of ethnic groups of the Korean Peninsula, the plant was also used for postpartum cleansing and in the practice of restoring energy balance.

In the territories of Vietnam and Laos, Angelica is found as a component of traditional tinctures and baths used in therapeutic and ablution ceremonies, especially among the mountain communities of the Miao and Tai peoples. In these cultures, Angelica was considered a plant that helps restore vitality after long illnesses or childbirth.

In ethnographic sources of Mongolia, Chinese Angelica is mentioned as one of the "warm" plants used in compresses and fat ointments prepared with yak fat. It was used in systems associating diseases with internal "wind," and it was considered a stabilizing element in the human body.

In a non-medical context, Chinese Angelica was used in China as a ritual incense, burned in the purification of space in the homes of women who had recently given birth, as well as a smoking plant in women's baths and postpartum wards. In the cultures of some provinces, the plant was considered a talisman protecting against "cold" and energy depletion, so the root was hung at the entrance of the house or placed under the pillow.

In the modern era, elements of the ethnomedical use of Angelica are preserved in the practices of traditional Chinese, Korean, and Tibetan medicine, and continue to be used in phytotherapeutic schools in East Asia and ethnic diaspora communities.