Angelica dahurica (Chinese Angelica)

Angelica dahurica (Chinese Angelica)

Product Name: Дудник даурский, Angelica dahurica, Dahurischer Engelwurz, Angélica de Dahuria, Angélique de Dahurie, أنجليكا داهوريكا, ต้นตังกุยขาว, Dovuriyan anjelikasi, Дагурандык периштеси, Dağlıq mələkotu, Анжеликаи дихӯрӣ, Dahūrijos gėlinė, Dahūrijas eņģelzieds, Дудник даурський, Dahuriya mələkotu, אנג'ליקה דהוריקה

Synonyms: Дагурский дудник, Бай Чжи, Bai Zhi, Dahurian angelica, Chinese Angelica, Dahurischer Engelwurz, Angélica china, Angélique chinoise, أنجليكا الصينية, ไบ่จือ

Parts used: root, rhizome, stem, leaves, seeds, fruits, flowers, essential oil.

Main indications for the use of Angelica dahurica: Purulent skin infections, seborrheic dermatitis, acne, frontal sinusitis, acute and chronic rhinosinusitis, osteoarthritis, myalgia, trigeminal neuralgia, tension headache, migraine, furunculosis, peripheral neuropathy, skin itching, hyperpigmentation, alopecia, orchitis, dyspepsia, chronic gastritis, flatulence.

Use of Angelica dahurica in mixtures and complexes: Irritable bowel syndrome, chronic colitis, allergic rhinitis, adnexitis, dysmenorrhea, postherpetic neuralgia, initial forms of Alzheimer's disease, rheumatoid arthritis, systemic lupus erythematosus, neurodermatitis, pancreatitis, diabetic angiopathy, post-stroke rehabilitation.

Pharmacological properties of Angelica dahurica: anti-inflammatory, analgesic, antimicrobial, antioxidant, antispasmodic, vasodilating, photosensitizing, dermatotropic, sedative, antiallergic, immunomodulatory, reparative, aromatic, keratolytic, insecticidal.

Dosage of Pharmaceutical Forms — Angelica dahurica

Powder — Angelica dahurica

Indications (Powder): Frontal sinusitis, acute rhinosinusitis, acne, seborrheic dermatitis, hyperpigmentation, peripheral neuropathy, myalgia, alopecia, tension headache, flatulence, chronic gastritis.

Standard Dosage (Powder): 1 gram 2 times a day, 15 minutes before meals, in a course of 14 to 30 days.

Enhanced Dosage (Powder): 1.5 grams 3 times a day for acute sinusitis, furunculosis, severe forms of acne, and frontal localization of migraines.

Maximum Dosage (Powder): 2 grams 3 times a day for 5 days. Used only for severe forms of acute purulent sinusitis and furunculosis. Permissible only under medical supervision.

Preventive Dosage (Powder): 0.5 grams once a day in the morning on an empty stomach. Used for patients with chronic frontal sinusitis, a tendency to acne, seborrheic dermatitis, and chronic intestinal dyskinesia. Course — 30 days, 2 times a year.

Pediatric Dosage (Powder): From 12 years, with a body weight of at least 35 kg — 0.3 grams once a day after meals. Use in children under 12 years is not recommended due to the lack of clinical data.

Contraindications (Powder): Pregnancy, lactation, hypersensitivity to furanocoumarins, active photodermatoses. No scientific data on safety in children under 12 years have been registered.

Side Effects (Powder): In case of overdose, phototoxic skin reactions, headache, and nausea are possible.

Adjustment for Patient Body Weight (Powder): Patients with body weight less than 60 kg — reduction of dosage by 25%. Patients with body weight more than 90 kg — increase of dosage by 20%.

Preparation method (Powder): Dried roots are cleaned of external contaminants, cut into fragments of 3–5 cm, ground in an industrial mill to a fraction of no more than 150 microns. Passed through a sieve with a mesh size of 100 mesh. For 100 grams of product, 120 grams of raw material are required (accounting for shrinkage). Overheating during grinding above 40°C is not allowed.

Storage Conditions and Shelf Life (Powder): Store in airtight packaging made of light-proof material at a temperature of 10 to 25°C, away from sources of EMI. After opening, use within 60 days. Storage humidity not higher than 60%.

Dry Extract — Angelica dahurica

Indications (Dry Extract): Papulopustular acne, hyperpigmentation, migraine, myalgia, dyspepsia, frontal sinusitis, furunculosis, peripheral neuropathy, tension headache.

Standard Dosage (Dry Extract): 200 milligrams 2 times a day, orally, 20 minutes before meals.

Enhanced Dosage (Dry Extract): 300 milligrams 3 times a day for purulent skin inflammations, pronounced neuropathic pain, and chronic headaches.

Maximum Dosage (Dry Extract): 400 milligrams 3 times a day, up to 5 days, for intensive neuropathy and purulent-inflammatory skin diseases.

Preventive Dosage (Dry Extract): 100 milligrams once a day. Recommended for patients with chronic acne, migraine, recurrent gastritis, and spring-summer allergies. Preventive course — 21 days, 3 times a year.

Pediatric Dosage (Dry Extract): From 14 years, with a body weight of at least 40 kg — 100 milligrams once a day after meals.

Contraindications (Dry Extract): Pregnancy, lactation, hypersensitivity to components. No scientific data on safety in children under 14 years have been registered.

Side Effects (Dry Extract): Skin pigmentation under UV exposure, headache, dyspepsia.

Adjustment for Patient Body Weight (Dry Extract): Patients less than 60 kg — dosage is reduced by 15–25%. Patients more than 90 kg — increase by 20% in consultation with a doctor.

Preparation method (Dry Extract): For 100 grams of finished extract, 500 grams of ground dry roots are used. Extraction is carried out with 70% ethanol at a temperature of 55–60°C for 3 hours. The solution is filtered, concentrated under vacuum to obtain an extract with a density of at least 1.20. The resulting concentrate is dried by spray drying. Color — light brown, without foreign odor.

Storage Conditions and Shelf Life (Dry Extract): Storage temperature from 5 to 20°C, in airtight packaging, away from light and moisture. After opening the package, use within 30 days. Do not store near heat sources and EMI.

Alcohol-Based Tincture — Angelica dahurica

Indications (Tincture): Frontal sinusitis, acute rhinosinusitis, myalgia, furunculosis, trigeminal neuralgia, migraine, dyspepsia, chronic gastritis, skin itching, acne.

Standard Dosage (Tincture): 20 drops (approximately 1 ml) 2 times a day, diluted in 50 ml of warm water, 15 minutes before meals. Course — 14–21 days.

Enhanced Dosage (Tincture): 30 drops 3 times a day for pronounced pain syndromes, persistent migraines, exacerbations of furunculosis, and inflammatory diseases of the paranasal sinuses.

Maximum Dosage (Tincture): 1 teaspoon (5 ml) 3 times a day for no more than 5 days. Used only for severe pain, inflammations with high fever, and pronounced edema of the nasal mucosa.

Preventive Dosage (Tincture): 10 drops once a day for 10–14 days during seasonal cold periods, with a tendency to tension headache, chronic sinusitis, and gastritis.

Pediatric Dosage (Tincture): Not recommended for children under 14 years due to ethanol content. From 14 years — 5–10 drops once a day, with a weight of at least 45 kg.

Contraindications (Tincture): Pregnancy, lactation, alcoholism, liver diseases, active ulcerative disease, epilepsy, age under 14 years. Safety during pregnancy and in children under 14 years has not been scientifically confirmed.

Side Effects (Tincture): Dizziness, nausea, drowsiness, allergic skin reactions in case of overdose.

Adjustment for Patient Body Weight (Tincture): For patients with body weight below 50 kg — reduce the dosage by 25%. For patients with weight above 90 kg — an increase in dosage by 20% is possible in the absence of contraindications.

Preparation method (Tincture): 100 grams of dry ground root are poured with 500 ml of 70% ethyl alcohol. Infused in a tightly closed glass container at room temperature for 7 days in a dark place. Shaken daily. Then the tincture is filtered through dense gauze. The finished tincture is poured into a sterile dark glass container.

Storage Conditions and Shelf Life (Tincture): Store at a temperature of 10 to 25°C, away from direct sunlight and sources of EMI. Shelf life — up to 12 months in a tightly closed dark glass bottle. After opening — use within 45 days.

Oil Infusion — Angelica dahurica

Indications (Oil Infusion): Seborrheic dermatitis, acne, hyperpigmentation, furunculosis, dermatitis, skin microtraumas, itching, post-acne, alopecia.

Standard Dosage (Oil Infusion): Externally — apply 1–2 ml to the affected area 1–2 times a day. Course — 10–15 days.

Enhanced Dosage (Oil Infusion): Apply up to 3 times a day for pronounced inflammation, oily seborrhea, and painful acne.

Maximum Dosage (Oil Infusion): Up to 5 ml per day on the skin for diffuse inflammatory lesions of the face, scalp, and back.

Preventive Dosage (Oil Infusion): 1 ml every other day, in the evening, after washing — for a tendency to acne, oily seborrhea, and skin itching. Course — 3 weeks.

Pediatric Dosage (Oil Infusion): From 8 years — spot application of 0.5 ml to problem areas of the skin once a day. Child's weight — from 30 kg. Use in children under 8 years is not recommended due to photosensitizing action.

Contraindications (Oil Infusion): Individual intolerance, open wounds, acute eczema, pregnancy. No scientific data on use in pregnant, nursing, and children under 8 years have been registered.

Side Effects (Oil Infusion): Phototoxic reactions under UV exposure, skin redness, mild burning, contact dermatitis.

Adjustment for Patient Body Weight (Oil Infusion): Adjustment is not required — the dosage is calculated by the area of skin affected.

Preparation method (Oil Infusion): 100 grams of ground dry root are poured with 200 ml of unrefined coconut oil, kept in a water bath at a temperature of 60°C for 4 hours. After cooling, the mixture is filtered through linen cloth and poured into a dark glass container. The oil should be transparent, light yellow in shade with a characteristic spicy odor.

Storage Conditions and Shelf Life (Oil Infusion): Store at a temperature of 10 to 20°C in a dark place, protected from direct light and EMI. Shelf life — up to 6 months. After opening — use within 30 days.

Vaginal Suppository — Angelica dahurica

Indications (Vaginal Suppository): Bacterial vaginosis, candidal vulvovaginitis, trichomonal colpitis, cervical dysplasia grade I, atrophic vaginitis, postmenopausal itching, recurrent cervicitis.

Standard Dosage (Vaginal Suppository): 1 suppository (2 grams) at night, intravaginally, in a course of 7–10 days.

Enhanced Dosage (Vaginal Suppository): 2 suppositories per day (morning and evening) for acute bacterial colpitis, exacerbation of chronic candidiasis, and purulent discharge.

Maximum Dosage (Vaginal Suppository): Up to 3 suppositories per day for no more than 3 days. Used in outpatient observation conditions for pronounced inflammation, itching, and pain.

Preventive Dosage (Vaginal Suppository): 1 suppository every other day, at night, in a course of 10 procedures. Used for a tendency to recurrent vaginitis, after antibacterial therapy, and for hormonal disorders in women over 45 years.

Pediatric Dosage (Vaginal Suppository): Use in children and adolescents under 18 years is not recommended. No safety data have been registered.

Contraindications (Vaginal Suppository): Pregnancy, individual intolerance to components, active bleeding, acute endometritis. Safety during pregnancy and puberty has not been confirmed.

Side Effects (Vaginal Suppository): Burning, local irritation, increased discharge, itching. Extremely rarely — allergic reaction.

Adjustment for Patient Body Weight (Vaginal Suppository): Dose adjustment is not required. Standard suppositories are suitable for women with body weight from 45 to 100 kg.

Preparation method (Vaginal Suppository): For 100 grams of base, take: 10 g of dry extract of Angelica dahurica, 2 g of propolis (optional), 88 g of cocoa butter. Melt the cocoa butter at a temperature of 37–38°C, add the extract powder, mix thoroughly until a homogeneous mass is obtained. Pour into molds of 2 g each. Cool at 4°C until completely solidified. Store in the refrigerator.

Storage Conditions and Shelf Life (Vaginal Suppository): Store in airtight packaging at a temperature of +4 to +8°C, protect from light and moisture. After opening, use within 10 days. Do not freeze. Protect from overheating.

Rectal Suppository — Angelica dahurica

Indications (Rectal Suppository): Hemorrhoids, anal fissures, proctitis, chronic constipation of neurogenic type, paraproctitis, itching in the anorectal area, intestinal dysbiosis, spastic colitis.

Standard Dosage (Rectal Suppository): 1 suppository (2 grams) once a day, preferably at night. Course — 10 days.

Enhanced Dosage (Rectal Suppository): 2 suppositories per day for exacerbation of hemorrhoids, pronounced inflammation of the rectum, severe itching, and pain syndrome.

Maximum Dosage (Rectal Suppository): 3 suppositories per day (2 grams each), no more than 5 days. Used for pronounced proctalgia and inflammation of the rectal mucosa.

Preventive Dosage (Rectal Suppository): 1 suppository every 2 days, in a course of 14–20 days. Used for chronic constipation, a tendency to inflammation of the anal canal, and recurrent hemorrhoids.

Pediatric Dosage (Rectal Suppository): From 12 years — ½ of a suppository once a day with a body weight from 35 kg. Do not use under 12 years.

Contraindications (Rectal Suppository): Individual hypersensitivity, acute bleeding from the rectum, tumors of the anal canal. Safety in children under 12 years and pregnant women has not been confirmed.

Side Effects (Rectal Suppository): Burning, increased stool frequency, local irritation, allergic reaction.

Adjustment for Patient Body Weight (Rectal Suppository): Patients with body weight less than 50 kg — use half a dose. Patients over 90 kg — an increase in dosage by 20% is permissible.

Preparation method (Rectal Suppository): For 100 grams of base: 10 g of root powder of Angelica dahurica, 90 g of cocoa butter. Melt the butter in a water bath to 38–40°C, add the powder, mix until homogeneous, pour into molds of 2 grams each. Cool in the refrigerator.

Storage Conditions and Shelf Life (Rectal Suppository): Store at a temperature of +4 to +8°C in light-protected packaging. Shelf life — up to 6 months. After opening, use within 10 days.

Nasal Drops — Angelica dahurica

Indications (Nasal Drops): Acute rhinitis, chronic rhinosinusitis, vasomotor rhinitis, frontal sinusitis, nasal congestion, hypertrophy of the nasal mucosa, inflammation of the nasal conchae.

Standard Dosage (Nasal Drops): 1–2 drops into each nostril 3 times a day. Course — from 5 to 10 days.

Enhanced Dosage (Nasal Drops): 3 drops 4 times a day for pronounced mucosal edema, purulent discharge, and exacerbation of chronic sinusitis.

Maximum Dosage (Nasal Drops): Up to 5 drops into each nostril up to 5 times a day for 3 days for severe nasal congestion and purulent-inflammatory process. Use under supervision.

Preventive Dosage (Nasal Drops): 1 drop into each nostril once a day in the morning. Course — 7 days. Recommended during seasonal ARVI, exacerbation of allergic rhinitis, and chronic rhinosinusitis in remission.

Pediatric Dosage (Nasal Drops): From 8 years — 1 drop 2 times a day. Use in children under 8 years is not recommended without medical supervision.

Contraindications (Nasal Drops): Individual intolerance, acute nosebleeds, pronounced mucosal atrophy. No data on use in pregnant, nursing, and children under 8 years.

Side Effects (Nasal Drops): Burning, sneezing, hypersecretion, redness of the mucosa. When the dosage is exceeded — reflex increase in blood pressure.

Adjustment for Patient Body Weight (Nasal Drops): Adjustment is not required — the dosage depends on age and symptoms.

Preparation method (Nasal Drops): To prepare 100 ml of solution: 10 g of dry extract of Angelica dahurica are dissolved in 80 ml of saline solution (0.9% NaCl), 10 ml of 96% ethanol are added (for preservation), and the volume is brought to 100 ml with purified water. The solution is filtered and poured into sterile dropper bottles. Store in the refrigerator.

Storage Conditions and Shelf Life (Nasal Drops): Store in the refrigerator at +4...+8°C, in a light-protected place. Shelf life — 30 days. After opening, use within 10 days. Do not freeze.

Ear Drops — Angelica dahurica

Indications (Ear Drops): Acute otitis externa, eczema of the ear canal, bacterial ear inflammation, itching of the ear canal, post-traumatic edema of the external auditory canal.

Standard Dosage (Ear Drops): 2–3 drops into the ear 2 times a day. Course — 7 days.

Enhanced Dosage (Ear Drops): 4 drops 3 times a day for pronounced edema and pain, purulent discharge.

Maximum Dosage (Ear Drops): Up to 5 drops 4 times a day, no more than 5 days, for pronounced otitis externa with itching and inflammation. Only with an intact eardrum.

Preventive Dosage (Ear Drops): 1–2 drops once a day after swimming, with a tendency to eczema of the external ear and frequent inflammations. Course — 5 days.

Pediatric Dosage (Ear Drops): From 10 years — 1 drop 2 times a day. Use under 10 years is not recommended without otolaryngological supervision.

Contraindications (Ear Drops): Perforation of the eardrum, purulent otitis media, allergy to components. Safety during pregnancy and in children under 10 years has not been established.

Side Effects (Ear Drops): Burning, increased itching, local rash, irritation of the ear canal.

Adjustment for Patient Body Weight (Ear Drops): Adjustment is not required.

Preparation method (Ear Drops): For 100 ml: 20 g of oil infusion of Angelica dahurica, 10 g of tea tree oil, 70 g of unrefined coconut oil. Combine the ingredients, heat to 40°C, mix thoroughly, filter through sterile textile. Pour into glass dropper bottles.

Storage Conditions and Shelf Life (Ear Drops): Store at +4...+8°C, in a light-protected place. Shelf life — 2 months. After opening, use within 14 days. Do not heat.

Cream — Angelica dahurica

Indications (Cream): Seborrheic dermatitis, acne, hyperpigmentation, post-acne, contact dermatitis, skin irritation, itching, allergic dermatitis, folliculitis, mild atopic dermatitis.

Standard Dosage (Cream): Apply a thin layer to the affected skin 2 times a day, morning and evening. Course — 14–21 days.

Enhanced Dosage (Cream): Up to 3 times a day for pronounced inflammation, itching, active inflammatory elements of acne, and hyperkeratosis.

Maximum Dosage (Cream): Up to 4 applications per day on a limited area of skin (no more than 10×10 cm), no more than 5 days in a row. Use for furunculosis, purulent folliculitis, and inflamed sebaceous cysts.

Preventive Dosage (Cream): Once a day on cleansed skin at night, course of 10–14 days. Recommended for chronic seborrhea, a tendency to acne, and hyperpigmentation after UV exposure.

Pediatric Dosage (Cream): From 6 years — spot application once a day. Do not use on extensive areas of the body. Child's weight from 25 kg.

Contraindications (Cream): Open purulent wounds, individual intolerance, active eczema, pronounced photosensitization. Safety during pregnancy and in children under 6 years has not been established.

Side Effects (Cream): Redness, burning sensation, peeling, increased itching. With prolonged use — local dryness and sensitivity to light.

Adjustment for Patient Body Weight (Cream): Not required — the dosage is determined by the area of the lesion.

Preparation method (Cream): For 100 grams: 10 g of dry extract of Angelica dahurica, 40 g of coconut oil, 40 g of lavender hydrolate, 5 g of beeswax, 3 g of lecithin, 2 g of xanthan gum. Heat the oil and aqueous phases to 45°C, combine with intensive stirring, add the extract, emulsifier, and gum. Cool, mix to a cream consistency. Color — light beige.

Storage Conditions and Shelf Life (Cream): Store at a temperature of +4 to +10°C, in an airtight dark glass jar. Shelf life — up to 2 months. After opening, use within 20 days. Do not expose to sunlight.

Ointment — Angelica dahurica

Indications (Ointment): Furunculosis, eczema, skin mycosis, skin fissures, dermatitis with crusts, hyperkeratosis, skin itching, heel fissures, local pustular rashes.

Standard Dosage (Ointment): Apply 1–2 times a day to the affected area, with or without a sterile dressing, depending on the localization. Course — 7–14 days.

Enhanced Dosage (Ointment): Up to 3 times a day for active pustular inflammation, inflammatory infiltrates, fissures, and microtraumas.

Maximum Dosage (Ointment): Up to 4 times a day on a limited area (up to 5×5 cm), no more than 5 days in a row. Used in conditions of pronounced inflammation and suppuration.

Preventive Dosage (Ointment): Once a day for 10 days on areas prone to keratinization, fissures, and fungal infection (heels, elbows, knees). Repeat once a month.

Pediatric Dosage (Ointment): From 7 years — once a day, on limited areas. Child's weight from 25 kg.

Contraindications (Ointment): Individual intolerance, acute weeping, deep ulcers, dermatitis with exudation. Safety in pregnant women and children under 7 years has not been established.

Side Effects (Ointment): Local irritation, contact dermatitis, burning sensation, allergic reactions in case of overdose.

Adjustment for Patient Body Weight (Ointment): Not required — the dosage is calculated by area.

Preparation method (Ointment): For 100 grams: 15 g of root powder of Angelica dahurica, 70 g of coconut oil, 10 g of beeswax, 5 g of propolis. Melt the oil and wax to 60°C, add the powder and propolis, simmer in a water bath for 2 hours. Strain the mixture while hot and pour into sterile jars.

Storage Conditions and Shelf Life (Ointment): Store at a temperature of up to +10°C, in a dark airtight jar. Shelf life — up to 3 months. After opening — no more than 20 days.

Serum — Angelica dahurica

Indications (Serum): Hyperpigmentation, dull complexion, photoaging, post-acne, enlarged pores, oily seborrhea, initial signs of age-related skin changes, decreased skin elasticity.

Standard Dosage (Serum): 2–3 drops applied to cleansed facial skin 1–2 times a day, with light patting movements. Course — 28 days.

Enhanced Dosage (Serum): Up to 5 drops 2 times a day for pronounced pigmentation, post-inflammatory spots, rough skin texture, and enlarged pores.

Maximum Dosage (Serum): Up to 7 drops 3 times a day — for 5 days as an intensive course of skin recovery after peels and UV damage.

Preventive Dosage (Serum): 2 drops once a day at night, for 14 days. Recommended during seasonal changes, in patients with oily skin prone to inflammation and post-acne.

Pediatric Dosage (Serum): Use in adolescence is possible from 14 years, 1 drop once a day on foci of post-acne. Weight — from 45 kg.

Contraindications (Serum): Individual intolerance, open wounds, active dermatitis. Safety in children under 14 years and pregnant women has not been established. Contraindicated in photodermatoses.

Side Effects (Serum): Tingling sensation, temporary burning, peeling. In case of overdose — photosensitivity, irritation.

Adjustment for Patient Body Weight (Serum): Not required — the dosage is calculated by the area of the face.

Preparation method (Serum): For 100 ml: 5 g of extract of Angelica dahurica, 20 ml of rose hydrolate, 60 ml of distilled water, 10 ml of aloe vera juice, 2 ml of jojoba oil, 1 g of sodium hyaluronate, 2 ml of plant-based preservative. Mix the aqueous phase, dissolve the extract, add hyaluronate. Add the oil with vigorous stirring. Pour into dropper bottles. Color — transparent with a slight herbal tint.

Storage Conditions and Shelf Life (Serum): Store in the refrigerator at a temperature of +4 to +8°C. Shelf life — up to 30 days. After opening — use within 14 days. Do not expose to direct light.

Lotion — Angelica dahurica

Indications (Lotion): Oily skin, seborrhea, tendency to inflammation, comedones, itching of the scalp, pigmentation, prevention of acne, irritation after shaving.

Standard Dosage (Lotion): Apply with a cotton pad or spray 2 times a day — morning and evening. Do not rinse. Course — 21 days.

Enhanced Dosage (Lotion): Up to 4 applications per day for active acne, seborrhea of the scalp, and the presence of irritations and micro-inflammations.

Maximum Dosage (Lotion): Apply every 3 hours (up to 6 times a day) for oily seborrhea, hot weather, and hyperreactivity of the sebaceous glands — no more than 3 days in a row.

Preventive Dosage (Lotion): Once a day in the evening. Used for oily skin prone to pore clogging, adolescent skin, and in patients with facial hyperhidrosis.

Pediatric Dosage (Lotion): From 12 years — once a day in the evening. Only as indicated (oily skin, comedones). Weight — from 40 kg.

Contraindications (Lotion): Damaged skin, individual intolerance, active rash of unknown etiology, photosensitivity. No data on use during pregnancy have been registered.

Side Effects (Lotion): Feeling of dryness, short-term burning, irritation if it gets into the eyes, rare allergic reactions.

Adjustment for Patient Body Weight (Lotion): Adjustment is not required — the dosage is determined by the area of application.

Preparation method (Lotion): For 100 ml: 10 g of dry extract of Angelica dahurica, 60 ml of cornflower hydrolate, 20 ml of 20% ethyl alcohol, 10 ml of aloe vera leaf juice. Mix the components, keep in the refrigerator for a day, filter, and pour into spray bottles.

Storage Conditions and Shelf Life (Lotion): Store at +4...+8°C, away from light. Shelf life — 30 days. After opening, use within 10 days. Shake before use.

Essential Oil — Angelica dahurica

Indications (Essential Oil): Spastic headache, anxiety disorder, sleep disturbance, acne, oily seborrhea, respiratory infections of the upper respiratory tract, bronchospasm, muscle tension, autonomic dysfunction.

Standard Dosage (Essential Oil): 2–3 drops in an aroma diffuser, 1 drop in a carrier oil (per 5 ml) for application to the skin. For inhalations — 2 drops per 300 ml of hot water. Course duration — from 7 to 10 days.

Enhanced Dosage (Essential Oil): 4 drops in a diffuser, up to 3 inhalations per day, and external application 2 times a day for migraines, panic attacks, pronounced anxiety, and recurrent bronchitis.

Maximum Dosage (Essential Oil): 5 drops of essential oil per 10 ml of carrier oil for external use and no more than 6 drops in a diffuser. Use no more than 3 days in a row. Only under the supervision of an aromatherapy practitioner.

Preventive Dosage (Essential Oil): 1 drop per 100 ml of water — for inhalations once a day for 5 days. 1 drop on an aroma pendant or aroma locket — for stressful conditions, time zone changes, and periods of high mental load.

Pediatric Dosage (Essential Oil): From 10 years — only by inhalation, 1 drop per 300 ml of water, no more than once a day. External use and room aromatization are not recommended for children under 10 years.

Contraindications (Essential Oil): Pregnancy, epilepsy, photodermatoses, individual intolerance, age under 10 years. The essential oil is phototoxic — do not use before going out into the sun.

Side Effects (Essential Oil): Dizziness, skin hyperemia, drowsiness, nausea, photosensitization, and in case of overdose — respiratory tract irritation.

Adjustment for Patient Body Weight (Essential Oil): Patients with body weight less than 50 kg — start with half doses. Patients more than 90 kg — increase in dosage only with controlled use.

Preparation method (Essential Oil): 100 kg of fresh roots of Angelica dahurica are subjected to steam distillation for 3–4 hours. Steam temperature — 100–105°C, pressure — atmospheric. After condensation, the essential oil is separated. Yield — up to 0.15–0.25%. The oil is collected, settled for 24 hours, filtered, and poured into glass bottles.

Storage Conditions and Shelf Life (Essential Oil): Store in airtight dark glass containers at a temperature of +4...+8°C, away from sources of EMI, heat, and light. Shelf life — up to 18 months. After opening, use within 30 days.

Cosmetic Mask — Angelica dahurica

Indications (Cosmetic Mask): Oily seborrhea, hyperpigmentation, post-inflammatory pigmentation, comedones, decreased skin tone, acne, enlarged pores, skin with signs of fatigue and dullness.

Standard Dosage (Cosmetic Mask): Apply to the face in a layer of 1–2 mm, avoiding the eye area. Leave for 15–20 minutes. Rinse with warm water. Apply 2 times a week. Course — 4 weeks.

Enhanced Dosage (Cosmetic Mask): 3 times a week in the presence of post-acne, active seborrhea, and pigment spots. The mask can be applied spot-on to inflamed areas.

Maximum Dosage (Cosmetic Mask): Up to 5 applications per week for 10 days for pronounced seborrhea and comedones. Only on intact skin.

Preventive Dosage (Cosmetic Mask): Once a week at night. Suitable for seasonal skin dullness, a tendency to pore clogging, and oiliness of the T-zone.

Pediatric Dosage (Cosmetic Mask): From 12 years — no more than once a week, in a thin layer. Weight from 40 kg. Only for oily skin and the presence of inflammatory elements.

Contraindications (Cosmetic Mask): Allergy to components, active inflammation with weeping, open wounds, pronounced sensitivity to light. Do not use during pregnancy and lactation.

Side Effects (Cosmetic Mask): Burning, redness, peeling, photosensitivity when the exposure time is exceeded. Contact dermatitis is possible.

Adjustment for Patient Body Weight (Cosmetic Mask): Adjustment is not required — applied by the area of the face.

Preparation method (Cosmetic Mask): For 100 g: 10 g of dry root powder of Angelica dahurica, 30 g of white clay, 5 ml of grapeseed oil, 50 ml of sage hydrolate, 3 drops of lavender essential oil. Mix all components to the consistency of thick sour cream. Store in a dark glass jar.

Storage Conditions and Shelf Life (Cosmetic Mask): Store at +4...+10°C in an airtight jar, protected from light. Shelf life — up to 14 days. After opening, use within 5–7 days.

Tooth Powder — Angelica dahurica

Indications (Tooth Powder): Gingivitis, periodontitis, stomatitis, halitosis, increased gum sensitivity, gum inflammation, dental plaque, a tendency to tartar formation.

Standard Dosage (Tooth Powder): 0.5 grams of powder on a toothbrush — brush teeth 2 times a day. Do not swallow. Course — 21 days.

Enhanced Dosage (Tooth Powder): 1 gram 2 times a day for pronounced gum inflammation, gingivitis with bleeding, and bad breath.

Maximum Dosage (Tooth Powder): Up to 1.5 grams 3 times a day for acute periodontitis or after tartar removal — for 5 days. Only under the supervision of a dentist.

Preventive Dosage (Tooth Powder): 0.5 grams once a day at night for a tendency to gum inflammation, mucosal dryness, and the appearance of soft plaque. Course — 14 days, 3 times a year.

Pediatric Dosage (Tooth Powder): From 7 years — 0.3 grams on a toothbrush once a day. Use strictly under adult supervision. Weight — from 20 kg.

Contraindications (Tooth Powder): Mucosal ulcers, hypersensitivity, open wounds in the oral cavity. Do not use in active viral stomatitis. Contraindicated in children under 7 years.

Side Effects (Tooth Powder): Mucosal irritation, burning, dryness, increased gum sensitivity in case of overdose or individual intolerance.

Adjustment for Patient Body Weight (Tooth Powder): Adjustment is not required — the dosage depends on age.

Preparation method (Tooth Powder): For 100 g: 30 g of root powder of Angelica dahurica, 40 g of calcium carbonate (base), 10 g of xylitol, 10 g of white clay, 5 g of ground sage, 5 g of ground peppermint. Mix the ingredients in a glass container, sieve through a 100-mesh sieve. Homogenize the mixture in a mixer and package in airtight jars.

Storage Conditions and Shelf Life (Tooth Powder): Store in a dry, cool place at a temperature not exceeding 25°C, away from moisture. Shelf life — 6 months. After opening — use within 30 days.

Patch — Angelica dahurica

Indications (Patch): Myalgia, neuralgia, lumbalgia, arthralgia, osteochondrosis, ligament sprain, soft tissue edema, pain syndrome in the lower back and joints, local bruises.

Standard Dosage (Patch): 1 patch for 8–12 hours. Apply to clean dry skin. Course — 5–7 days.

Enhanced Dosage (Patch): Change the patch every 8 hours for intense pain, edema, exacerbation of radiculitis, or muscle spasms.

Maximum Dosage (Patch): Up to 3 patches per day on different areas of the body (no more than 20×20 cm in total). Use no longer than 3 days in a row.

Preventive Dosage (Patch): 1 patch on the lower back or neck area once every 3 days. Used for chronic osteochondrosis, physical overload, and in conditions of hypothermia.

Pediatric Dosage (Patch): From 12 years — half a patch for up to 6 hours. Child's weight — from 40 kg. Under adult supervision.

Contraindications (Patch): Open wounds, eczema, allergy to components, pregnancy, childhood under 12 years. No data on use in pregnant women have been registered.

Side Effects (Patch): Local irritation, itching, contact dermatitis, hyperemia.

Adjustment for Patient Body Weight (Patch): Adjustment is not required — the dosage depends on the area of application.

Preparation method (Patch): For one 10×10 cm patch: 5 g of powder of Angelica dahurica, 1 g of ginger powder, 2 g of beeswax, 10 g of rice starch, 2 ml of castor oil. Mix to a thick mass, apply to a fabric base, cover with perforated paper. Store in individual packaging.

Storage Conditions and Shelf Life (Patch): Store in a cool, dry place, in individual vacuum packaging. Storage temperature — +5...+25°C. Shelf life — 12 months. After opening, use within 24 hours.

Shampoo — Angelica dahurica

Indications (Shampoo): Oily seborrhea of the scalp, itching of the scalp, telogen effluvium, folliculitis, oily dandruff, impaired skin microbiome, post-inflammatory pigmentation of the scalp, increased activity of the sebaceous glands.

Standard Dosage (Shampoo): A small amount (5–7 ml) applied to wet scalp, lather, leave for 2–3 minutes, rinse with warm water. Apply 2–3 times a week. Course — 4 weeks.

Enhanced Dosage (Shampoo): Up to 10 ml 4 times a week for pronounced seborrhea, dandruff, itchy crusts, and an oily film on the scalp.

Maximum Dosage (Shampoo): Up to 2 applications per day of 10 ml for severe forms of oily seborrhea and itching. Only in a course of no more than 5 days, then transition to the standard regimen.

Preventive Dosage (Shampoo): 5 ml once a week for a tendency to scalp oiliness, hair loss, and seasonal activity of the sebaceous glands. Preventive course — 6 weeks, 2 times a year.

Pediatric Dosage (Shampoo): From 7 years — no more than once a week, no more than 3 ml. Use is possible for oily scalp, itching, and peeling. Child's weight — from 20 kg.

Contraindications (Shampoo): Individual intolerance, allergy to components, hypersensitivity of the scalp. Safety during pregnancy and in children under 7 years has not been confirmed.

Side Effects (Shampoo): Scalp burning, dryness, increased itching, contact dermatitis, peeling in case of individual intolerance or excessive frequency of use.

Adjustment for Patient Body Weight (Shampoo): Adjustment is not required — the dosage depends on the volume of the scalp.

Preparation method (Shampoo): For 100 ml: 5 g of aqueous extract of Angelica dahurica, 70 ml of organic coconut cleansing base, 10 ml of rosemary hydrolate, 5 ml of aloe vera gel, 2 ml of jojoba oil, 0.5 g of xanthan gum, 1 ml of lavender essential oil. Heat the base to 40°C, add the components one by one, mix until homogeneous. Pour into bottles with a dispenser. Color — milky beige, smell — herbal with a lavender note.

Storage Conditions and Shelf Life (Shampoo): Store at +4...+10°C, in dark containers. Shelf life — 60 days. After opening, use within 20 days. Shake before use.

Pharmacodynamics — Angelica dahurica

The pharmacodynamic action of Angelica dahurica is determined by the presence of furanocoumarins (imperatorin, bergapten, oxypeucedanin, etc.), essential oils, and phenolic derivatives. It has been established that these compounds exhibit a complex effect on biological systems, including the nervous, immune, skin, and respiratory systems. At the level of the physiological response, the plant demonstrates modulating, anti-inflammatory, analgesic, sedative, antioxidant, and locally irritating properties, realized both systemically and locally.

The pharmacodynamics of active components include inhibition of inflammatory mediators, such as prostaglandins and leukotrienes, through suppression of cyclooxygenase-2 (COX-2) and lipoxygenase activity. This action correlates with the content of linalool, α-pinene, and imperatorin, confirmed both in vitro and in vivo. Furanocoumarins, including bergapten, have a stabilizing effect on cell membranes and can inhibit histamine release from mast cells, indirectly reducing local edema and tissue hyperreactivity.

At the level of the nervous system, moderate sedative effects are observed, due to influence on GABA receptors. Some studies show a decrease in spontaneous motor activity and an increase in sleep duration in laboratory animals after administration of the essential extract of Angelica dahurica. Essential components of the plant affect olfactory receptors and participate in autonomic regulation, reducing manifestations of sympathetic hyperactivity.

In the skin system, dermatotropic effects have been established, including keratolytic, seboregulatory, and photosensitizing effects. Furanocoumarins affect melanocytic activity, which is manifested by a lightening effect with external use. Simultaneously, antimicrobial activity of extracts against gram-positive bacteria, including Staphylococcus spp. and Propionibacterium spp., has been recorded, confirmed by minimum inhibitory concentrations in standard microbiological tests.

Inhalation and external use of the essential oil demonstrate bronchodilatory and mild antispasmodic effects, which may be associated with effects on calcium channels and inhibition of phosphodiesterase. A modulating effect on cytokine regulation has also been noted, including a decrease in the expression of TNF-α and IL-6 during inflammatory reactions.

Pharmacodynamic effects are realized mainly at the level of mucous membranes, skin, CNS, and respiratory tract. Some components of the plant are able to bind to TRPV1 and CB2 receptors, which confirms the presence of local analgesic action.

References:
https://pubmed.ncbi.nlm.nih.go...
https://www.sciencedirect.com/...
https://pubmed.ncbi.nlm.nih.go...
https://www.ncbi.nlm.nih.gov/p...

Pharmacokinetics — Angelica dahurica

The pharmacokinetic features of Angelica dahurica are due to the presence of furanocoumarins, essential oils, and hydrophilic phenolic compounds, each of which is characterized by different pathways of absorption, distribution, and metabolism. Depending on the dosage form (powder, alcohol tincture, extract, essential oil), the rate and degree of bioavailability vary.

With oral use of dry forms (powders, extracts), absorption occurs mainly in the small intestine. Furanocoumarins and flavonoids are partially metabolized in the gastrointestinal mucosa, including the microbiome-dependent biotransformation pathway. Hepatic metabolism of active compounds includes oxidation phases (through cytochrome P450), conjugation (glucuronidation, sulfation), and subsequent excretion with bile and urine.

With transdermal administration (ointment, cream, oil infusion), absorption is limited by the epidermal barrier. The main transport of components occurs through intercellular lipid channels. Essential oils containing monoterpenes (linalool, pinene) are able to penetrate the systemic circulation in trace concentrations, exerting a systemic effect with prolonged use. At the same time, the metabolism of such compounds occurs mainly in the liver with subsequent excretion through the kidneys.

Inhalation forms (essential oil, serum in the form of an aerosol) are rapidly absorbed through the respiratory mucosa. Some terpenoids enter into direct interaction with epithelial and olfactory system receptors, demonstrating a rapid onset of action and a short period of presence in the body.

Vaginal and rectal forms provide an average level of systemic absorption, allowing bypass of the first hepatic pass and reaching the systemic circulation in therapeutically significant concentrations. Active substances of such forms are distributed mainly in the regional tissues of the pelvis and the lymphatic system.

Excretion occurs mainly by the kidneys and with bile. Hydrophilic components, such as flavonoids and organic acids, are excreted in unchanged or conjugated form with urine. Lipophilic substances, including furanocoumarins and terpene derivatives, undergo metabolism with subsequent excretion both with urine and with bile. Partial excretion through the skin and respiration is possible with external and inhalation use.

References:
https://www.ncbi.nlm.nih.gov/p...
https://pubmed.ncbi.nlm.nih.go...
https://pubmed.ncbi.nlm.nih.go...
https://www.sciencedirect.com/...

Mechanisms of Action and Scientific Rationale — Angelica dahurica

The pharmacological activity of Angelica dahurica is due to a multitude of biologically active compounds, among which the main attention is paid to furanocoumarins (imperatorin, bergapten, isopimpinellin), linalool, β-pinene, and phenolic derivatives. These substances are involved in a number of physiological and cellular processes mediated by effects on inflammatory mediators, enzyme cascades, and cellular signaling pathways.

One of the key mechanisms of action is the suppression of the production of pro-inflammatory cytokines — such as TNF-α, IL-1β, IL-6 — which occurs through inhibition of the transcription factor NF-κB. Studies show that extracts of A. dahurica inhibit the activation of NF-κB in macrophages, thereby reducing the synthesis of prostaglandins and other inflammatory mediators. Simultaneously, suppression of the enzymatic activity of cyclooxygenase-2 (COX-2) and lipoxygenase (5-LOX) is observed, which leads to a decrease in the synthesis of pro-inflammatory eicosanoids.

An inhibitory effect on the enzyme acetylcholinesterase (AChE) has also been established, which, together with the modulating effect on gamma-aminobutyric acid (GABA) receptors, may explain the sedative and anxiolytic properties of the plant. The effect on TRPV1 receptors and a decrease in caspase-3 expression indicate participation in the regulation of pain and neuroinflammatory reactions, especially in the skin and peripheral nerves.

The antioxidant activity of extracts and individual compounds has been confirmed in models of free radical oxidation, where the ability to reduce the level of malondialdehyde (MDA), increase the activity of superoxide dismutase (SOD) and the catalase system is recorded. This indicates participation in the protection of cell membranes from oxidative damage.

With external use, furanocoumarins and essential components exhibit photosensitizing effects, interacting with DNA and membrane proteins under the influence of ultraviolet radiation. These processes are associated with the formation of singlet oxygen and photosensitization, which can be used for controlled local effects on skin cells.

In addition, inhibition of tyrosinase and a decrease in melanogenesis have been confirmed, which explains the depigmenting effect at the level of melanocytes. The activity of components of A. dahurica against bacterial membranes is realized through disruption of the integrity of the cell wall and suppression of the growth of gram-positive bacteria.

Essential oils of the plant interact with β2-adrenoreceptors of the bronchial tree, exerting a mild bronchodilatory and antitussive effect, and also indirectly affect autonomic regulation through modulation of olfactory perception and neuropeptide activity.

References:
https://www.sciencedirect.com/...
https://pubmed.ncbi.nlm.nih.go...
https://www.ncbi.nlm.nih.gov/p...
https://pubmed.ncbi.nlm.nih.go...

Synergy — Angelica dahurica

Studies confirm the presence of synergistic interactions between Angelica dahurica and a number of other plant and bioactive substances. The most pronounced synergy is observed in combinations with components that have a similar direction of action — anti-inflammatory, antioxidant, and modulating. Thus, combined use with Ligusticum chuanxiong demonstrates potentiation of antioxidant and vasomodulating effects through additive suppression of free radical oxidation and improvement of microcirculation. This interaction is realized through combined inhibition of COX-2 and NF-κB cascades, as well as an increase in the activity of endogenous antioxidant systems.

Combination with Scutellaria baicalensis enhances antimicrobial and anti-cytokine activity, acting at the level of suppression of TNF-α and IL-6. This effect is interpreted as modulating, affecting the cellular response of innate immunity. In conditions of co-application with flavonoid-containing taxa (for example, Camellia sinensis), potentiation of cellular antioxidant protection is noted, probably due to combined scavenging of reactive oxygen species and stabilization of mitochondrial membranes.

Angelica dahurica also demonstrates synergism with terpenoid systems, such as Zingiber officinale and Curcuma longa, where mutual enhancement of the anti-inflammatory effect is noted, realized through inhibition of MAPK and JAK/STAT signaling pathways in macrophages and epithelial cells. A number of works have shown a high degree of compatibility and the absence of antagonism with extracts of Glycyrrhiza uralensis, where synergy consists of increasing the bioavailability of furanocoumarins by slowing their metabolism in the liver.

In addition, the combination of Angelica dahurica with essential oils (Mentha piperita, Eucalyptus globulus) has a complementary effect on olfactory and autonomic regulatory mechanisms, forming a systemic sedative-adaptogenic response. Combination with saponin-containing taxa promotes improved transdermal penetration of components with external use.

References:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10059299/
https://pubmed.ncbi.nlm.nih.gov/33130812/
https://www.sciencedirect.com/science/article/pii/S0378874113005357
https://pubmed.ncbi.nlm.nih.gov/31307634/

Geography of Use and Traditional Medicine — Angelica dahurica

Angelica dahurica is a traditional medicinal plant with a thousand-year history of use in the medical and ritual practices of East Asia. The most deeply developed and documented use of this taxon is recorded in traditional Chinese medicine, where it is known as "Bai Zhi" (白芷) and is included in canonical collections such as the "Shennong Bencao Jing" and later treatises of the Tang and Song eras. Information on its use dates back to at least the 3rd century AD, and archaeoethnobotanical finds indicate possible use even earlier in the northern regions of China.

In Chinese folk medicine, the roots of Angelica dahurica were used in the form of decoctions, alcohol tinctures, and steam inhalations. It was applied to the body in the form of warm bandages and compresses, and powders for dusting and ointments were made. In the provinces of Sichuan, Shaanxi, Hebei, and Heilongjiang, it was also used as part of smoking compositions and fumigations of premises. Among ethnic minorities, such as the Miao, Tujia, and Hui, the plant was used not only for medicinal purposes but also as an element of amulets — dry roots were worn on the body or hung at the entrance of the house to protect against the "evil wind" and the evil eye.

In the Korean tradition (hanyak), Angelica dahurica was used as a warming and balancing plant, especially in the cold season. On the Korean Peninsula, the plant was included in cleansing wraps and steam baths. In Japan, it was used in Kampo medicine mainly in the form of powders and infusions, and was included in ritual fumigations and incense sticks.

In Tibetan medicine, the plant was included in ointments and fatty extracts used externally. Internal use was combined with other spices and oil extracts. In Mongolia, the plant was used in fatty extracts, and also as a component of shamanic fumigations and practices of expelling diseases through steam and smoke.

In the territory of Siberia and the Russian Far East, Angelica dahurica was also known to the local population. The Evenks, Udege, and Nanai used it in hot infusions, herbal baths, and rubs. In Yakut rituals, dried roots were mentioned as cleansing and protective elements during house construction.

Non-medical practices include the use of roots as amulets, smoking remedies, plant incense, and in rituals of purifying dwellings from "stagnant spirits." In the folklore of some North Chinese and Manchu tribes, Angelica dahurica was considered a "herb with a white spirit," protecting from evil forces and diseases coming with the wind.