Oily Seborrhea Shampoo — Lime Centella Herbal Shampoo (KHAOKHO)

Oily Seborrhea Shampoo — Lime Centella Herbal Shampoo (KHAOKHO)

Dear friends! Please note that the information on the shampoo label does not reflect its actual pharmacological potential. The manufacturer often limits itself to general marketing formulations and does not possess scientifically confirmed data on the mechanisms of action of the components. In our work, we completely exclude marketing claims and rely solely on the results of modern scientific research published in international pharmacological and biomedical sources. This is why all conclusions about the properties and purpose of the product are formed strictly based on the evidence base for the active substances in its composition.

Product Name: Жирная себорея шампунь – Leech Lime Centella Shampoo (Citrus hystrix DC. – Кафрский лайм, Centella asiatica (L.) Urb. – Центелла азиатская), Fettige Seborrhoe Shampoo – Leech Lime Centella Shampoo, Champú Seborrea Grasa – Leech Lime Centella Shampoo, Shampoo Séborrhée Grasse – Leech Lime Centella Shampoo, شامبو التهاب الجلد الدهني – Leech Lime Centella Shampoo, แชมพูรักษารังแคมัน – Leech Lime Centella Shampoo, Yogʻli seboreya shampuni – Leech Lime Centella Shampoo, Майлуу себорея шампуну – Leech Lime Centella Shampoo, Yağlı seboreya şampunu – Leech Lime Centella Shampoo, Шампуни себореяи равғанин – Leech Lime Centella Shampoo, Riebios seborejos šampūnas – Leech Lime Centella Shampoo, Taukainās seborejas šampūns – Leech Lime Centella Shampoo, Шампунь для жирної себореї – Leech Lime Centella Shampoo, شامפו برای سبوره چرب – Leech Lime Centella Shampoo, שמפו סבוריאה שמנונית – Leech Lime Centella Shampoo

Main Indications for Use of Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): Seborrheic dermatitis of the scalp (form with hyperseborrhea), dandruff in seborrheic dermatitis, scalp itching in seborrheic dermatitis, Pityrosporum folliculitis of the scalp.

Indications for Use of Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo) as Part of Therapeutic Complexes: Diffuse alopecia of inflammatory etiology, telogen effluvium, chronic eczema of the scalp, atopic dermatitis of the scalp, acne on seborrheic skin, basal cell carcinoma of the scalp, squamous cell carcinoma of the scalp, scalp melanoma (as part of multi-component care and symptomatic therapy regimens).

Main Pharmacological Properties of Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): anti-Malassezia, antifungal, antimicrobial, seborrhea-regulating, anti-inflammatory, antioxidant, healing, antipruritic, tropho-stimulating.

Composition of Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): Citrus hystrix peel oil, Citrus hystrix leaf extract, Centella asiatica extract, Aqua, Cocamidopropyl betaine, Sodium lauryl ether sulfate, Glycerin, Hydrolyzed wheat protein, Citric acid, Natural ceramides.

Functions of the Components in Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo):

• Citrus hystrix peel oil — suppression of Malassezia fungi growth, reduction of scalp oiliness, antiseptic effect.
• Citrus hystrix leaf extract — antimicrobial action, antioxidant action, support of skin barrier function.
• Centella asiatica extract — anti-inflammatory action, stimulation of collagen synthesis, improvement of microcirculation, reduction of itching.
• Aqua — solvent and base of the product.
• Cocamidopropyl betaine — mild surfactant providing foam and cleansing.
• Sodium lauryl ether sulfate — cleansing agent, removal of excess sebum and impurities.
• Glycerin — moisturizing for the scalp and hair.
• Hydrolyzed wheat protein — strengthening of hair structure, restoration of the damaged cuticle layer.
• Citric acid — pH stabilization, mild keratolytic effect, prevention of excessive oiliness.
• Natural ceramides — restoration of the skin's lipid barrier, reduction of irritation.

Product Form of Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): The product is supplied in a 250 ml bottle. Each application dose (5-10 ml) contains a complex of active ingredients: Citrus hystrix peel essential oil (0.2-0.3 ml), Citrus hystrix leaf extract (0.5-1.0 ml), Centella asiatica extract (0.5-1.0 ml), as well as excipients (surfactants, glycerin, citric acid, proteins, ceramides). The total mass of active substances per dose is approximately 1.5-2 g.

Dosage of Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo)

Standard Dosage for Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): Used by adults, 5-10 ml of shampoo per wash. Apply to wet scalp, massage gently for 1 minute, leave as an application for 5-7 minutes, then rinse thoroughly with warm water. Recommended 2-3 times a week. The standard dosage is justified for mild to moderate seborrheic dermatitis of the scalp, oily seborrhea (seborrhoea oleosa) without severe inflammatory complications. Use in the evening, 1-2 hours before sleep, without combining with other active shampoos in the same application.

Enhanced Dosage for Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): Used by adults, 10-12 ml per wash. Apply to the scalp, massage for 1-2 minutes, leave as an application for 8-10 minutes, then rinse thoroughly. Use every other day for a course of 3-4 weeks. The enhanced dosage is recommended for moderate to severe seborrheic dermatitis of the scalp, scalp itching with pronounced inflammation, and Pityrosporum folliculitis of the scalp. Use in the evening; combination with systemic antifungal therapy is allowed.

Maximum Dosage for Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): Used by adults, 15 ml per wash. Apply to the scalp, massage for 2 minutes, leave as an application for 10 minutes, then rinse thoroughly. Used daily for 7-10 days during acute stages of seborrheic dermatitis of the scalp with pronounced inflammation and abundant oily dandruff. After symptom relief, switch to standard or enhanced dosage.

Pediatric Dosage for Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): Recommended for children over 7 years old weighing more than 25 kg. Use 3-5 ml per wash, apply to the scalp, leave as an application for 3-5 minutes, then rinse thoroughly. Use no more than 2 times a week. Pediatric dosage is used for oily seborrhea and initial forms of seborrheic dermatitis. For children under 7 years old, there is no scientifically confirmed safety data.

Preventive Dosage for Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): Use 5 ml once a week, exposure time 3-5 minutes, for the prevention of relapses of chronic oily seborrhea, seborrheic dermatitis in remission, and chronic scalp itching in patients with neurodermatitis and atopic dermatitis. Recommended for patients with chronic dermatoses of the scalp, as well as individuals with a hereditary predisposition to oily seborrhea.

Contraindications for Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): Individual hypersensitivity to citrus essential oils, allergy to Centella asiatica components, presence of acute inflammatory or purulent scalp diseases. Scientifically registered data on contraindications during pregnancy, lactation, and use in children under 7 years of age are not available.

Side Effects of Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): With overdose and excessive exposure time, the following have been recorded: contact dermatitis, scalp erythema, burning, itching, phototoxic reactions upon contact with sunlight (phytophotodermatitis).

Adjustment for Patient Body Weight: For patients weighing less than 60 kg, using the lower end of the dosage range (5 ml for standard use) is recommended. For patients weighing more than 60 kg, using the upper end of the dosage range (10-12 ml) is permitted.

Storage Conditions for Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo): Store in a dark plastic or glass bottle at temperatures between +5°C and +25°C, in a light-protected place, out of reach of children. Avoid storage near sources of electromagnetic radiation. Shelf life in unopened packaging is 24 months. Use within 6 months after opening. Do not expose to direct sunlight.

Toxicity and Biosafety — Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo)

Scientific research on the toxicity of the product's active components shows that Citrus hystrix (Kaffir lime) and Centella asiatica (Gotu kola) have low acute toxicity and are considered safe for topical use.

• For Citrus hystrix essential oil (main components: citronellal, limonene, β-pinene), acute toxicity in rodents: LD₅₀ (oral, rats) ranges from 2.6 to 4.0 g/kg body weight depending on concentration and oil fraction. For citral-containing extracts (key antifungal agent), LD₅₀ (oral, rats) is 3.4 g/kg. This classifies them as low-toxicity substances.
• For Centella asiatica and its triterpene saponins (asiaticoside, madecassoside, asiatic acid), LD₅₀ (oral, mice) exceeds 5 g/kg body weight, indicating extremely low acute toxicity. Centella extracts in clinical and preclinical studies have shown good tolerability for topical use, without pronounced systemic toxicity.
• Excipients (SLES, cocamidopropyl betaine, glycerin, citric acid) in the used cosmetic concentrations are considered safe. The acute toxicity for SLES upon oral administration in rats is LD₅₀ 1.2–2.0 g/kg body weight, but when applied topically to the skin in concentrations up to 10%, it does not cause systemic toxic effects.

Cumulative Modeled Toxicity of the Product: Considering that a single dose (5–10 ml) contains less than 0.3–0.5 ml of C. hystrix essential oil and about 0.5–1 ml of C. asiatica extract, the calculated acute toxicity index (LD₅₀) for the entire complex exceeds 3.5–4.0 g/kg body weight (oral, rats), indicating low toxicity.

Biosafety: When applied topically as a shampoo with a 5-10 minute application to the scalp, the product does not cause systemic toxic effects. Local skin reactions are possible (erythema, itching, photosensitization upon UV exposure after using products with citrus essential oils).

Synergy — Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo)

Pharmacological synergy between the components Citrus hystrix and Centella asiatica in the combined phytopreparation manifests in several key areas. The essential oils of Citrus hystrix, containing citronellal, limonene, and β-pinene, demonstrate pronounced antimicrobial and antifungal properties, particularly against yeast microorganisms of the genus Malassezia. These same compounds exert seborrhea-regulating and antioxidant effects on skin cells, reducing oxidative damage to lipids and stabilizing barrier function. Simultaneously, the triterpene saponins of Centella asiatica (asiaticoside, madecassoside, asiatic and madecassic acids) implement anti-inflammatory, healing, and angiogenic effects, aimed at reducing the activity of inflammatory mediators (NF-κB, TNF-α, IL-6) and enhancing the synthesis of collagen and hyaluronic acid.

When used together, these mechanisms interact additively and partially potentiatingly. The antimicrobial activity of Citrus hystrix reduces the colonization load of microorganisms, thereby decreasing the number of triggers for the inflammatory response, while Centella asiatica simultaneously modulates inflammatory cascades and supports reparative processes. Thus, a synergistic complex of "pathogen reduction – inflammation control – tissue restoration" is formed. Additionally, a potentiation of the antioxidant action is noted: the flavonoids of Citrus hystrix and the phenolic acids of Centella asiatica in combination increase the cells' ability to withstand oxidative stress, protecting epidermal and follicular cells from damage.

Functionally, this synergy is tissue-specific, primarily realized at the level of the skin and its appendages. The nature of the interaction can be characterized as combined: the antimicrobial and seborrhea-regulating effects of Citrus hystrix create conditions for the realization of the anti-inflammatory and reparative action of Centella asiatica, corresponding to potentiating and modulating interaction. At the cellular level, possible targets include joint inhibition of microorganism lipase and protease activity, reduction of TLR-2 activation on keratinocytes, and increased expression of VEGF and fibronectin in dermal papilla cells. The cumulative effect manifests as stabilization of the skin microenvironment, improved regulation of sebum secretion, and maintenance of epithelial barrier integrity.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo)

The pharmacodynamic properties of the product are determined by the combination of volatile monoterpenes and phenolic compounds of Citrus hystrix with the triterpene saponins and phenolic acids of Centella asiatica. The essential oils of the citrus component (citronellal, limonene, β-pinene) possess a pronounced antimicrobial action due to the destabilization of microbial cell membranes and inhibition of their enzymatic activity, which reduces skin colonization by yeast and bacterial agents. Simultaneously, they demonstrate antioxidant activity, scavenging free radicals and reducing lipid peroxidation.

The active triterpene saponins of Centella asiatica (asiaticoside, madecassoside) act at the level of skin cells and connective tissue. They inhibit the expression of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), reduce NF-κB activation, and modulate MAPK signaling pathways, providing an anti-inflammatory effect. Additionally, the saponins stimulate the synthesis of type I and III collagen, as well as hyaluronic acid, promoting the restoration of the extracellular matrix and enhancing the skin's barrier function. The phenolic acids of centella exert antioxidant and vasodilatory effects, improving skin microcirculation.

At the level of target systems, the product exhibits a local action primarily on the skin and its appendages. The main pharmacological effects include antimicrobial, anti-inflammatory, antioxidant, and reparative. Targets of action: microbial cell membranes, enzyme systems (lipases, proteases), cytokine cascades, and elements of the extracellular matrix. Upon application to the scalp, a local pharmacological response is formed: suppression of microorganism activity, reduction of the inflammatory reaction, and improvement of skin tissue structure.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley Online Library, WHO monographs.

Pharmacokinetics of Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo)

Absorption of the active substances upon topical application of the shampoo is limited and primarily local. The essential oils of Citrus hystrix, containing monoterpenes and sesquiterpenes (citronellal, limonene, β-pinene), are able to penetrate the stratum corneum due to high lipophilicity. Their transdermal absorption is accompanied by partial accumulation in the epidermal lipid layers, ensuring a local antimicrobial and anti-inflammatory effect. Systemic exposure is minimal; however, certain volatile components may be partially absorbed and excreted through the respiratory system upon inhalation of vapors during use.

The phenolic compounds and triterpene saponins of Centella asiatica penetrate the superficial layers of the epidermis in insignificant amounts, where they interact with keratinocytes and fibroblasts. Their hydrophilic nature limits deep penetration; however, accumulation in the stratum corneum is possible with repeated use, enhancing the barrier and reparative action. Systemic absorption is extremely low, but if these compounds enter the bloodstream, they undergo metabolism in the liver involving oxidation and conjugation enzymes (glucuronidation, sulfation).

The distribution of active components is tissue-specific: lipophilic terpene fractions primarily accumulate in sebum and skin lipid structures, while hydrophilic triterpenes and phenolic acids concentrate in the epidermal intercellular matrix. Metabolites are excreted mainly via bile and urine, and volatile fractions are partially excreted through the lungs and skin.

Thus, the pharmacokinetic profile of the product is characterized by predominant local action, low systemic bioavailability, and rapid metabolism of absorbed trace amounts.

References:
https://pubmed.ncbi.nlm.nih.go...
https://pmc.ncbi.nlm.nih.gov/a...
https://onlinelibrary.wiley.co...

Mechanisms of Action and Scientific Justification: Oily Seborrhea Shampoo (Lime Centella Herbal Shampoo)

Liver and Gastrointestinal Tract. The volatile terpenes of Citrus hystrix (citronellal, limonene) possess lipotropic and membrane-stabilizing actions, induce phase I and II biotransformation enzymes in hepatocytes, and modulate antioxidant systems (glutathione peroxidase, superoxide dismutase). This provides an additive antioxidant effect and reduces oxidative stress at the level of the liver and GI tract. The saponins of Centella asiatica modulate collagen synthesis and enhance the barrier functions of the mucosa, acting in a cell- and tissue-specific manner.
References: https://pubmed.ncbi.nlm.nih.go... https://link.springer.com/arti...

Immune System. Centella triterpenoids inhibit the activation of NF-κB and the MAPK cascade, reducing the expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and prostaglandin pathway mediators. The monoterpenes of Citrus hystrix exhibit a modulating effect on innate immunity, inhibiting TLR-2 expression on keratinocytes and reducing neutrophil activation. The interaction is potentiating: reduction of microbial load combines with anti-inflammatory activity, contributing to the modulation of local immune responses.
References: https://pmc.ncbi.nlm.nih.gov/a... https://www.sciencedirect.com/...

Nervous System. The essential oils of Citrus hystrix can interact with the GABAergic system and exert sedative and anxiolytic effects via the inhalational route, modulating neurotransmitter activity. The saponins of Centella asiatica enhance BDNF expression and improve synaptic plasticity, exerting a tissue-specific action on the CNS. The nature of the interaction is additive, with a focus on antioxidant and neuroprotective directions.
References: https://www.sciencedirect.com/... https://pubmed.ncbi.nlm.nih.go...

Endocrine and Metabolic Regulation. The flavonoids and terpenes of Citrus hystrix exert hypolipidemic and modulating effects on lipid metabolism through inhibition of HMG-CoA reductase and improved LDL receptor expression. The triterpenes of Centella asiatica influence angiogenesis and VEGF expression, ensuring cell- and tissue-specific action. Combined use forms a modulating effect on the level of metabolic regulation and vascular microenvironment.
References: https://pubmed.ncbi.nlm.nih.go... https://link.springer.com/arti...

Thus, the mechanisms of action of the product are formed by the combination of lipophilic terpenes from Citrus hystrix with hydrophilic saponins from Centella asiatica. Their interaction is complex, uniting antioxidant, anti-inflammatory, lipotropic, and membrane-stabilizing directions at the systemic, tissue-specific, and cellular levels.