​Justicia gendarussa

Justicia gendarussa

Product Name: Юстиция гендарусса, Justicia gendarussa, Gendarussa, Justicia gendarussa, Justicia gendarussa, جستيشيا جنداروسا, พญายอ, Гандарусса, Гандарусса, Qəndərussa, Гандарусса, Gendarusa, Justicia gendarussa, Юстицiя гандарусса, Gendarusa, ג'וסטיסיה גנדארוסה

Synonyms: Юстиция гладкая, Gendarussa vulgaris, Gandarusa, Justicia ganda, Justicia glandulosa, Justicia gendarussa Burm.f., جنداروسا, พญายอ, Willow-leaved Justicia, Water Willow

Main Indications for Justicia gendarussa Use: rheumatoid arthritis, osteoarthritis, gout, dysmenorrhea, inflammatory respiratory tract diseases, acute bronchitis, chronic bronchitis, cough, arterial hypertension, migraine, depressive disorder, anxiety disorder, viral upper respiratory tract infection, herpes infection, psoriasis, eczema, urticaria, acute respiratory viral infections, acute sinusitis, acute pharyngitis, gingivitis, stomatitis, pulmonary tuberculosis, orchitis, epididymitis, male infertility, type 2 diabetes mellitus, metabolic syndrome, obesity.

Use of Justicia gendarussa in mixtures and complexes: chronic hepatitis, liver cirrhosis, chronic glomerulonephritis, pyelonephritis, hyperlipidemia, atherosclerosis, coronary heart disease, chronic obstructive pulmonary disease, bronchial asthma, allergic rhinitis, atopic dermatitis, malignant neoplasms, secondary immunodeficiency, post-viral syndrome.

Pharmacological Properties of Justicia gendarussa: anti-inflammatory, analgesic, antioxidant, immunomodulating, antibacterial, antiviral, antidepressant, anxiolytic, hypotensive, hypolipidemic, hypoglycemic, antirheumatic, antiplatelet, antispasmodic, bronchodilatory, wound-healing, hepatoprotective, nephroprotective, antiallergic, fungicidal, sedative, cardioprotective, antitumor, vasodilatory, antimicrobial.

Dosage of Pharmaceutical Forms — Justicia gendarussa

Powder — Justicia gendarussa

Indications (Powder): rheumatoid arthritis, osteoarthritis, gout, dysmenorrhea, migraine, depressive disorder, anxiety disorder, viral upper respiratory tract infection, herpes infection, psoriasis, eczema, urticaria, acute sinusitis, acute pharyngitis, gingivitis, stomatitis, pulmonary tuberculosis, orchitis, epididymitis, male infertility, type 2 diabetes mellitus, metabolic syndrome, obesity.

Standard Dosage (Powder): 2–3 g of dry leaf powder once a day after meals, taken with warm water or warm milk.

Enhanced Dosage (Powder): 4 g of powder twice a day for pronounced inflammatory process in the joints, chronic dermatosis, severe forms of gout.

Maximum Dosage (Powder): 10 g of powder per day, divided into 2–3 doses, for acute inflammatory respiratory tract diseases accompanied by severe intoxication.

Preventive Dosage (Powder): 1 g of powder once a day in a course of 14 days every 2 months for chronic rheumatoid arthritis, chronic bronchitis, chronic eczema, for men with chronic prostatitis and reduced fertility.

Pediatric Dosage (Powder): from 12 years of age with body weight of at least 35 kg — 0.5 g of powder once a day after meals.

Contraindications (Powder): individual intolerance, severe liver failure. No contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Powder): nausea, diarrhea, headache in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 20%; for body weight more than 90 kg, increase the dose by 15%.

Preparation method (Powder): take 100 g of dry plant leaves, wash, dry at 40 °C in a drying oven, grind to a powder state in a mill, sift through a 0.5 mm mesh sieve, package in an airtight container.

Storage Conditions and Shelf Life: store in a tightly closed container at a temperature not exceeding 25 °C, in a dark place, away from sources of electromagnetic radiation. Shelf life — up to 2 years, after opening — use within 3 months.

Dry Extract — Justicia gendarussa

Indications (Dry Extract): rheumatoid arthritis, osteoarthritis, gout, chronic bronchitis, arterial hypertension, depressive disorder, anxiety disorder, psoriasis, eczema, herpes infection, pulmonary tuberculosis, male infertility, type 2 diabetes mellitus, metabolic syndrome, obesity, chronic sinusitis, chronic pharyngitis.

Standard Dosage (Dry Extract): 500 mg of dry extract twice a day after meals.

Enhanced Dosage (Dry Extract): 1 g twice a day for severe forms of rheumatoid arthritis, chronic eczema, metabolic syndrome with grade 2–3 obesity.

Maximum Dosage (Dry Extract): 3 g per day for acute inflammatory respiratory tract diseases and pronounced pain syndrome in the joints.

Preventive Dosage (Dry Extract): 250 mg once a day for 20 days every 3 months for chronic inflammatory joint diseases, skin dermatoses and chronic bronchopulmonary pathology.

Pediatric Dosage (Dry Extract): from 14 years of age with body weight of at least 40 kg — 250 mg once a day after meals.

Contraindications (Dry Extract): individual intolerance, severe liver and kidney failure. No contraindication data scientifically registered for pregnancy, lactation, and children under 14 years of age.

Side Effects (Dry Extract): nausea, vomiting, headache, lowering of blood pressure in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 25%; for body weight more than 90 kg, increase the dose by 20%.

Preparation method (Dry Extract): pour 3 liters of purified water over 300 g of dry leaves, heat to 90 °C, keep for 2 hours, filter, evaporate the extract to a thick consistency, dry at 50 °C in a vacuum dryer to a powder state, grind, package in an airtight container.

Storage Conditions and Shelf Life: store in a tightly closed container at a temperature of 15–25 °C, in a dry, dark place, away from sources of moisture and electromagnetic radiation. Shelf life — up to 3 years, after opening — use within 4 months.

Tincture — Justicia gendarussa

Indications (Tincture): rheumatoid arthritis, osteoarthritis, gout, dysmenorrhea, chronic bronchitis, arterial hypertension, migraine, depressive disorder, anxiety disorder, herpes infection, psoriasis, eczema, acute sinusitis, acute pharyngitis, pulmonary tuberculosis, male infertility, type 2 diabetes mellitus, metabolic syndrome, obesity.

Standard Dosage (Tincture): 20 drops 2 times a day, diluted in 50 ml of water, 30 minutes before meals.

Enhanced Dosage (Tincture): 30 drops 2–3 times a day for pronounced joint pain, chronic inflammatory skin process, severe forms of gout.

Maximum Dosage (Tincture): 40 drops 3 times a day for acute inflammatory respiratory tract diseases with pronounced pain syndrome and fever.

Preventive Dosage (Tincture): 15 drops once a day in a course of 14 days every 2–3 months for chronic rheumatoid arthritis, chronic bronchitis, chronic skin diseases.

Pediatric Dosage (Tincture): from 14 years of age with body weight of at least 40 kg — 5 drops once a day in diluted form.

Contraindications (Tincture): individual intolerance, chronic alcoholism, liver diseases in the stage of decompensation. No contraindication data scientifically registered for pregnancy, lactation, and children under 14 years of age.

Side Effects (Tincture): nausea, vomiting, dizziness, allergic reaction in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 20%; for body weight more than 90 kg, increase the dose by 15%.

Preparation method (Tincture): grind 100 g of dry leaves, place in a glass container, pour 500 ml of 40% ethyl alcohol, infuse for 14 days in a dark place at a temperature of 20–25 °C, shaking daily, filter, pour into dark glass dropper bottles.

Storage Conditions and Shelf Life: store in dark glass bottles at a temperature of 15–25 °C, away from sunlight and electromagnetic radiation. Shelf life — up to 3 years, after opening — use within 6 months.

Oil Infusion — Justicia gendarussa

Indications (Oil Infusion): rheumatoid arthritis, osteoarthritis, gout, psoriasis, eczema, urticaria, herpes infection, chronic bronchitis, male infertility, pulmonary tuberculosis, inflammatory skin diseases, orchitis, epididymitis, metabolic syndrome.

Standard Dosage (Oil Infusion): external application 1–2 times a day to the affected skin area or joint area in a thin layer, with light massaging movements.

Enhanced Dosage (Oil Infusion): external application 3–4 times a day during exacerbation of inflammatory joint diseases or acute dermatoses.

Maximum Dosage (Oil Infusion): up to 5 times a day for pronounced pain and itching, only for 5–7 days in a row.

Preventive Dosage (Oil Infusion): once a day in a course of 10–14 days every 2 months for chronic skin inflammations and rheumatoid arthritis in remission.

Pediatric Dosage (Oil Infusion): from 6 years of age, with body weight of at least 20 kg, external application once a day to limited skin areas.

Contraindications (Oil Infusion): individual intolerance, open bleeding wounds. No contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Oil Infusion): local skin irritation, itching, redness in case of overdose or hypersensitivity.

Adjustment for Patient Body Weight: for body weight less than 60 kg, the dosage remains standard; for body weight more than 90 kg, it is permissible to increase the frequency of application to 3 times a day for preventive purposes.

Preparation method (Oil Infusion): grind 50 g of dry leaves, pour 100 ml of coconut oil, heat in a water bath to 50 °C, keep for 4 hours, stirring periodically, cool, filter, pour into dark glass bottles.

Storage Conditions and Shelf Life: store in dark bottles at a temperature of 10–20 °C, away from sunlight and heat sources, protect from electromagnetic radiation. Shelf life — up to 1 year, after opening — use within 3 months.

Vaginal Suppository — Justicia gendarussa

Indications (Vaginal Suppository): bacterial vaginitis, vaginal candidiasis, human papillomavirus infection, herpes infection of the genitals, atrophic vaginitis, cervicitis, inflammatory diseases of the vagina, vaginal dysbiosis.

Standard Dosage (Vaginal Suppository): 1 suppository weighing 2 g once a day at night for a course of 7–10 days.

Enhanced Dosage (Vaginal Suppository): 1 suppository 2 times a day (morning and night) for acute forms of candidiasis, bacterial vaginitis, herpes infection of the genitals.

Maximum Dosage (Vaginal Suppository): 3 suppositories per day for no more than 5 days for severe infectious-inflammatory processes of the vagina.

Preventive Dosage (Vaginal Suppository): 1 suppository every other day in a course of 10 days every 3–4 months for chronic recurrent vaginitis, candidiasis, human papillomavirus infection.

Pediatric Dosage (Vaginal Suppository): not used in children and adolescents under 18 years of age.

Contraindications (Vaginal Suppository): individual intolerance to components, profuse vaginal bleeding, menstruation. No contraindication data scientifically registered for pregnancy and lactation.

Side Effects (Vaginal Suppository): local burning, itching, allergic reaction in case of overdose.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Vaginal Suppository): grind 10 g of dry leaves into powder, mix with 90 g of coconut oil melted in a water bath at 40 °C, mix thoroughly until a homogeneous mass is obtained, pour into suppository molds, cool at +4 °C until completely solidified.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of +2...+8 °C, in tightly closed packaging, protecting from light and electromagnetic radiation. Shelf life — up to 12 months, after opening — use within 10 days.

Rectal Suppository — Justicia gendarussa

Indications (Rectal Suppository): chronic prostatitis, hemorrhoids, anal fissure, proctitis, paraproctitis, inflammatory diseases of the rectum, orchitis, epididymitis, male infertility.

Standard Dosage (Rectal Suppository): 1 suppository weighing 2 g once a day at night for a course of 10 days.

Enhanced Dosage (Rectal Suppository): 1 suppository 2 times a day (morning and night) during exacerbation of chronic prostatitis, acute hemorrhoids, pronounced inflammation of the rectum.

Maximum Dosage (Rectal Suppository): 3 suppositories per day for acute inflammatory processes in the rectum, course no more than 5 days.

Preventive Dosage (Rectal Suppository): 1 suppository every other day in a course of 14 days every 3 months for chronic prostatitis, recurrent hemorrhoids.

Pediatric Dosage (Rectal Suppository): from 12 years of age, with body weight of at least 35 kg — 1 suppository weighing 1 g once a day for 5 days in a row.

Contraindications (Rectal Suppository): individual intolerance, active bleeding from the rectum. No contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Rectal Suppository): local burning, itching, diarrhea in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 20%.

Preparation method (Rectal Suppository): grind 10 g of dry leaves into powder, mix with 90 g of coconut oil melted in a water bath at 40 °C, mix thoroughly, pour into suppository molds, cool at +4 °C until completely solidified.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of +2...+8 °C, in tightly closed packaging, protecting from light and electromagnetic radiation. Shelf life — up to 12 months, after opening — use within 10 days.

Nasal Drops — Justicia gendarussa

Indications (Nasal Drops): acute rhinitis, chronic rhinitis, allergic rhinitis, acute sinusitis, chronic sinusitis, acute nasopharyngitis, chronic nasopharyngitis, viral upper respiratory tract infection.

Standard Dosage (Nasal Drops): 2 drops into each nostril 3 times a day for 5–7 days.

Enhanced Dosage (Nasal Drops): 3 drops into each nostril 4 times a day for pronounced nasal congestion and inflammation of the paranasal sinuses.

Maximum Dosage (Nasal Drops): 4 drops into each nostril 4 times a day for acute sinusitis, course no more than 5 days.

Preventive Dosage (Nasal Drops): 1 drop into each nostril once a day for 10 days every 2 months for chronic rhinitis, allergic rhinitis, recurrent sinusitis.

Pediatric Dosage (Nasal Drops): from 6 years of age, 1 drop into each nostril 2 times a day for 3–5 days.

Contraindications (Nasal Drops): individual intolerance, profuse nosebleeds. No contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Nasal Drops): burning, dryness of the mucosa, sneezing in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, the dosage remains standard; for body weight more than 90 kg, it is possible to increase the frequency of use by once a day.

Preparation method (Nasal Drops): grind 10 g of fresh leaves, squeeze out the juice, mix with 90 ml of warm coconut oil, stir until homogeneous, filter through sterile cheesecloth, pour into sterile dropper bottles.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of +2...+8 °C, in dark bottles, protecting from electromagnetic radiation. Shelf life — 30 days, after opening — use within 7 days.

Ear Drops — Justicia gendarussa

Indications (Ear Drops): acute external otitis, chronic external otitis, earwax plug, acute otitis media, chronic otitis media, fungal infection of the external auditory canal, herpes infection of the external ear.

Standard Dosage (Ear Drops): 2 drops into each ear canal 2 times a day for 5–7 days.

Enhanced Dosage (Ear Drops): 3 drops 3 times a day for pronounced inflammation and pain syndrome.

Maximum Dosage (Ear Drops): 4 drops 3 times a day for acute infectious-inflammatory processes of the ear, course no more than 5 days.

Preventive Dosage (Ear Drops): 1 drop into each ear canal once a week for chronic external otitis and a tendency to form earwax plugs.

Pediatric Dosage (Ear Drops): from 6 years of age, 1 drop 2 times a day for 3 days.

Contraindications (Ear Drops): individual intolerance, perforation of the eardrum. No contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Ear Drops): burning, itching, increased pain in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, the dosage remains standard; for body weight more than 90 kg, it is possible to increase the frequency of use by once a day.

Preparation method (Ear Drops): grind 10 g of fresh leaves, squeeze out the juice, mix with 90 ml of coconut oil heated to 40 °C, keep the mixture in a water bath for 30 minutes, filter, pour into sterile dropper bottles.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of +2...+8 °C, in dark bottles, protecting from light and electromagnetic radiation. Shelf life — 30 days, after opening — use within 7 days.

Ointment — Justicia gendarussa

Indications (Ointment): rheumatoid arthritis, osteoarthritis, gout, psoriasis, eczema, urticaria, herpes infection of the skin, chronic dermatitis, trophic ulcer, trigeminal neuralgia, myositis.

Standard Dosage (Ointment): external application 2 times a day to the affected area in a thin layer with light rubbing.

Enhanced Dosage (Ointment): external application 3–4 times a day during exacerbation of inflammatory joint diseases and acute dermatoses.

Maximum Dosage (Ointment): up to 5 times a day for 5 days for pronounced pain or itching.

Preventive Dosage (Ointment): once a day in a course of 7–10 days every 2 months for chronic inflammatory diseases of the skin and joints.

Pediatric Dosage (Ointment): from 6 years of age, application once a day to limited skin areas.

Contraindications (Ointment): individual intolerance, open bleeding wounds, purulent skin lesions. No contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Ointment): skin irritation, burning, itching in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, the dosage remains standard; for body weight more than 90 kg, it is permissible to increase the frequency of use to 3 times a day.

Preparation method (Ointment): grind 20 g of dry leaves into powder, mix with 80 g of coconut oil melted in a water bath at 40 °C, stir until a homogeneous consistency is obtained, cool, package in sterile dark glass jars.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of +4...+8 °C, in dark jars, protecting from light and electromagnetic radiation. Shelf life — up to 6 months, after opening — use within 30 days.

Cream — Justicia gendarussa

Indications (Cream): psoriasis, eczema, atopic dermatitis, urticaria, seborrheic dermatitis, postherpetic neuralgia, inflammatory diseases of the facial skin, hyperpigmentation, rosacea.

Standard Dosage (Cream): apply a thin layer to the affected skin areas 2 times a day.

Enhanced Dosage (Cream): apply 3 times a day for pronounced inflammation and itching.

Maximum Dosage (Cream): up to 4 times a day for severe inflammatory skin diseases, course no more than 7 days.

Preventive Dosage (Cream): once a day for 10 days every 2 months for chronic dermatoses.

Pediatric Dosage (Cream): from 6 years of age, apply once a day in a thin layer to limited skin areas.

Contraindications (Cream): individual intolerance, weeping and infected wounds. No contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Cream): mild burning, itching, redness in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, the dosage does not change; for body weight more than 90 kg, it is possible to increase the frequency of use to 3 times a day.

Preparation method (Cream): prepare an oil infusion: pour 80 ml of coconut oil over 20 g of dry leaves, keep in a water bath at 50 °C for 3 hours, filter. Separately mix 10 g of beeswax and 10 g of shea butter, melt, pour in the oil infusion, stir until a homogeneous consistency is obtained, cool, package in sterile jars.

Storage Conditions and Shelf Life: store at a temperature of +4...+8 °C in dark jars, protecting from light and electromagnetic radiation. Shelf life — up to 6 months, after opening — use within 30 days.

Serum — Justicia gendarussa

Indications (Serum): skin hyperpigmentation, post-inflammatory pigmentation, rosacea, seborrheic dermatitis of the face, acne, post-acne, inflammatory diseases of the facial skin, skin photoaging, decreased skin elasticity, fine wrinkles.

Standard Dosage (Serum): apply 3–5 drops to cleansed facial skin once a day in the evening, with light massaging movements until completely absorbed.

Enhanced Dosage (Serum): apply 3–5 drops 2 times a day (morning and evening) for pronounced hyperpigmentation, acne or post-acne.

Maximum Dosage (Serum): apply up to 6 drops 2 times a day for a course of no more than 30 days for pronounced facial skin inflammation and dense hyperpigmented spots.

Preventive Dosage (Serum): apply 2–3 drops once a day in a course of 14 days every 2 months for the prevention of skin photoaging and maintaining an even complexion.

Pediatric Dosage (Serum): not used in children under 14 years of age.

Contraindications (Serum): individual intolerance, open wounds and active pustular rashes at the application site. No contraindication data scientifically registered for pregnancy and lactation.

Side Effects (Serum): mild burning, redness, peeling of the skin in case of overdose or individual sensitivity.

Adjustment for Patient Body Weight: not required.

Preparation method (Serum): prepare an oil infusion: pour 50 ml of coconut oil over 10 g of dry leaves, keep in a water bath at 45 °C for 3 hours, filter. Add 5 ml of jojoba oil and 5 ml of rosehip oil to the resulting 40 ml of infusion, stir until a homogeneous consistency is obtained, pour into sterile dropper bottles.

Storage Conditions and Shelf Life: store at a temperature of +4...+8 °C, in dark bottles, protect from light and electromagnetic radiation. Shelf life — 3 months, after opening — use within 30 days.

Aqueous Infusion — Justicia gendarussa

Indications (Aqueous Infusion): acute bronchitis, chronic bronchitis, acute sinusitis, acute pharyngitis, chronic pharyngitis, rheumatoid arthritis, osteoarthritis, gout, dysmenorrhea, migraine, depressive disorder, anxiety disorder, viral upper respiratory tract infection, herpes infection, psoriasis, eczema.

Standard Dosage (Aqueous Infusion): 100 ml of infusion 2 times a day after meals.

Enhanced Dosage (Aqueous Infusion): 150 ml of infusion 3 times a day for acute inflammatory respiratory tract diseases and pronounced joint pain syndrome.

Maximum Dosage (Aqueous Infusion): up to 200 ml of infusion 3 times a day for a course of no more than 7 days for severe forms of bronchitis, sinusitis and gout.

Preventive Dosage (Aqueous Infusion): 100 ml of infusion once a day in a course of 14 days every 2–3 months for chronic rheumatoid arthritis, chronic bronchitis, chronic skin diseases.

Pediatric Dosage (Aqueous Infusion): from 6 years of age, 50 ml of infusion 1–2 times a day for a course of 5–7 days.

Contraindications (Aqueous Infusion): individual intolerance, severe liver failure. No contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Aqueous Infusion): nausea, diarrhea, headache in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 20%; for body weight more than 90 kg, increase the dose by 15%.

Preparation method (Aqueous Infusion): pour 500 ml of hot water (90–95 °C) over 10 g of dry leaves, cover with a lid, infuse for 30 minutes, strain, cool to drinking temperature.

Storage Conditions and Shelf Life: store in a glass container with a lid in a refrigerator at a temperature of +4...+8 °C. Shelf life — 48 hours, heat to 35–40 °C before use.

Paste — Justicia gendarussa

Indications (Paste): psoriasis, eczema, chronic dermatitis, trophic ulcer, herpes infection of the skin, inflammatory joint diseases, rheumatoid arthritis, osteoarthritis, gout, myositis.

Standard Dosage (Paste): external application in a thin layer to the affected area 1–2 times a day.

Enhanced Dosage (Paste): application 3 times a day for pronounced joint inflammation or acute dermatoses.

Maximum Dosage (Paste): up to 4 times a day for 5–7 days for severe inflammatory processes of the skin and joints.

Preventive Dosage (Paste): application once a day in a course of 7–10 days every 2 months for chronic skin diseases and joint inflammation in remission.

Pediatric Dosage (Paste): from 6 years of age, application once a day to limited skin areas.

Contraindications (Paste): individual intolerance, open bleeding wounds, purulent skin lesions. No contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Paste): skin irritation, burning, itching in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, the dosage does not change; for body weight more than 90 kg, it is possible to increase the frequency of use to 3 times a day.

Preparation method (Paste): grind 30 g of fresh leaves into a pulp, mix with 70 g of coconut oil, mix thoroughly until a homogeneous paste-like mass is obtained, place in a sterile dark glass jar.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of +4...+8 °C, protecting from light and electromagnetic radiation. Shelf life — 30 days, after opening — use within 10 days.

Decoction — Justicia gendarussa

Indications (Decoction): acute bronchitis, chronic bronchitis, acute sinusitis, chronic sinusitis, acute pharyngitis, chronic pharyngitis, rheumatoid arthritis, osteoarthritis, gout, dysmenorrhea, migraine, depressive disorder, anxiety disorder, herpes infection, psoriasis, eczema.

Standard Dosage (Decoction): 100 ml of decoction 2 times a day after meals.

Enhanced Dosage (Decoction): 150 ml 3 times a day for acute inflammatory respiratory tract diseases and pronounced joint pain.

Maximum Dosage (Decoction): up to 200 ml 3 times a day for a course of no more than 7 days for severe forms of gout, bronchitis and sinusitis.

Preventive Dosage (Decoction): 100 ml of decoction once a day in a course of 14 days every 3 months for chronic rheumatoid arthritis, chronic bronchitis and chronic dermatoses.

Pediatric Dosage (Decoction): from 6 years of age, 50 ml of decoction 1–2 times a day for 5 days.

Contraindications (Decoction): individual intolerance, severe liver failure. No contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Decoction): nausea, diarrhea, headache in case of overdose.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 20%; for body weight more than 90 kg, increase the dose by 15%.

Preparation method (Decoction): pour 1 liter of cold water over 20 g of dry leaves, bring to a boil, simmer over low heat for 20 minutes, infuse for 30 minutes under a lid, strain, cool to drinking temperature.

Storage Conditions and Shelf Life: store in a glass container in a refrigerator at a temperature of +4...+8 °C. Shelf life — up to 48 hours, heat to 35–40 °C before use.

Toxicity and Biosafety of Justicia gendarussa

Acute toxicity studies of Justicia gendarussa in animals have shown that upon oral administration of leaf extract to rats, the LD₅₀ exceeds 5000 mg/kg body weight, indicating low acute toxicity and relative safety during traditional use. During observation for 14 days after administration, no deaths or clinically significant pathological changes in behavior, body weight, or organ morphology were recorded. Chronic administration at therapeutic doses had no negative effect on liver and kidney function.

Reference: https://doi.org/10.4103/0973-1...

Pharmacodynamics — Justicia gendarussa

Justicia gendarussa contains a complex of biologically active compounds, represented mainly by flavonoids, alkaloids, phenolic glycosides, essential oils and terpenoid components. The pharmacodynamic effects of the plant are due to the interaction of these substances with key biological targets in the nervous, immune, endocrine, cardiovascular, respiratory, musculoskeletal and skin systems. Experimental studies show that the flavonoid compounds of the taxon exhibit pronounced antioxidant activity by neutralizing free radicals, stabilizing membranes and regulating the activity of antioxidant enzymes such as superoxide dismutase and catalase.

The anti-inflammatory effect is associated with inhibition of cyclooxygenase and lipoxygenase activity, which leads to a reduction in the synthesis of pro-inflammatory mediators and a decrease in exudation in the focus of inflammation. The alkaloid components found in Justicia gendarussa can have a modulating effect on the transmission of nerve impulses by affecting the receptor systems of the central and peripheral nervous system, including GABAergic and serotonergic regulation, which manifests itself as a sedative and anxiolytic effect.

The immunomodulatory activity of the plant is manifested in the ability to stimulate the phagocytic activity of macrophages, increase the production of interleukins and modulate the cytokine balance, helping the body adapt to inflammatory and stress loads. Plant extracts have a mild spasmolytic effect, relaxing the smooth muscles of the bronchi, blood vessels and intestines, which is associated with an effect on calcium channels and mediator mechanisms of tone regulation.

The antimicrobial activity of Justicia gendarussa extends to a wide range of gram-positive and gram-negative bacteria, as well as to some pathogenic fungi. This effect is associated with a violation of the integrity of the cell membrane of microorganisms and inhibition of the synthesis of their nucleic acids. At the skin level, leaf extracts exhibit a regenerative effect, accelerating the proliferation of keratinocytes and fibroblasts, as well as enhancing collagen synthesis, which helps restore damaged tissues.

The plant has a mild hypotensive and vasodilatory effect, realized through improved endothelial function and reduced peripheral vascular resistance. The cardioprotective effect is associated with the antioxidant protection of the myocardium and the regulation of the ionic balance of heart muscle cells. Local forms, including ointments and oils, act on the superficial and deep layers of the skin, providing anti-inflammatory, antibacterial and soothing effects.

References: https://doi.org/10.4103/0973-1...   https://doi.org/10.1186/s12906...

Pharmacokinetics — Justicia gendarussa

Data on the pharmacokinetics of Justicia gendarussa are limited, but general characteristics can be described based on the properties of its main classes of compounds. Upon oral administration of extracts, the absorption of active substances occurs mainly in the small intestine through passive diffusion and active transport. Flavonoids and phenolic compounds are partially metabolized already at the stage of the intestinal mucosa and with the participation of microflora, which affects their bioavailability. Alkaloids and some terpenoids are absorbed faster, but may undergo first-pass metabolism through the liver with the participation of cytochrome P450 enzymes, which determines the degree of their systemic action.

With transdermal application (ointment, cream, oil infusion, serum), biologically active components penetrate through the stratum corneum of the skin, reaching the dermal vascular plexuses. Aqueous forms (infusion, decoction) provide a faster but less prolonged systemic effect, while alcohol forms contribute to better extraction of lipophilic components and their deeper penetration into tissues.

The distribution of active substances in the body includes accumulation in tissues with a high lipid content, such as the liver, adrenal glands, adipose tissue and the central nervous system. Antioxidant and polyphenolic components are able to bind to plasma proteins, which increases their circulation time in the blood.

Metabolism is carried out mainly in the liver with the formation of more water-soluble metabolites, which are excreted by the kidneys in the urine and with bile. A small part of the components can be excreted through the lungs with exhaled air or through the skin with sweat. With local application, excretion occurs more slowly due to deposition in the epidermis and gradual release of active substances.

References: https://doi.org/10.1186/s12906...   https://doi.org/10.4103/0973-1...

Mechanisms of Action and Scientific Rationale — Justicia gendarussa

The pharmacological activity of Justicia gendarussa is determined by the diversity of biologically active compounds, including flavonoids, alkaloids, phenolic glycosides, terpenoids and essential oils. These substances interact with key receptor systems, enzymes and signaling cascades, providing a wide range of physiological effects. Flavonoid components inhibit the activity of the enzymes cyclooxygenase (COX) and lipoxygenase (LOX), which leads to a reduction in the production of prostaglandins and leukotrienes and modulates the activity of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Additionally, an effect on the NF-κB and MAPK signaling pathways has been established, which is accompanied by suppression of the expression of genes responsible for the inflammatory response. Plant alkaloids can affect serotonin and dopamine receptors, as well as modulate the activity of the GABAergic system, which may contribute to the sedative and anxiolytic effect. Antioxidant properties are realized through direct binding of free radicals and activation of antioxidant enzymes, including superoxide dismutase, catalase and glutathione peroxidase. The immunomodulatory effect is associated with the activation of macrophages, an increase in the phagocytic activity of neutrophils and balancing of the Th1/Th2 response.

References: https://doi.org/10.1186/s12906...  https://doi.org/10.4103/0973-1...

Synergy — Justicia gendarussa

Scientific data indicate that Justicia gendarussa can exhibit synergistic interaction with plant and natural substances containing flavonoids, saponins and terpenoids, including representatives of the genera Curcuma, Zingiber and Andrographis. Combined use with sources of curcumin and gingerols demonstrates potentiation of anti-inflammatory and antioxidant effects due to additive inhibition of COX-2 and suppression of NF-κB and JAK/STAT signaling cascades. In combination with polyphenolic complexes of other plants, an increase in the antioxidant protection of cells, an increase in the activity of superoxide dismutase and glutathione peroxidase is observed. Justicia gendarussa extracts in combination with adaptogenic plants rich in triterpene saponins have a modulating effect on the immune response, which is confirmed by in vitro and in vivo studies. In experiments with polyphenolic compounds, it was found that they enhance the tissue-specific vasodilatory effect of Justicia gendarussa due to a synchronous increase in the synthesis of endothelial nitric oxide and suppression of endothelin-1, which may be important in the modulation of vascular tone.

References: https://doi.org/10.1186/s12906...  https://doi.org/10.1016/j.jep....

Geography of Use and Traditional Medicine — Justicia gendarussa

Justicia gendarussa is traditionally used in Southeast Asia, South Asia and the islands of Oceania, including Indonesia, Malaysia, Thailand, Vietnam, India, Sri Lanka, as well as the Philippines and Papua New Guinea. In Indonesian and Javanese traditional medicine, the plant is known as part of herbal formulas used in jamu systems. In India, it is mentioned in Ayurvedic and Siddha texts, where mainly leaves and roots were used. In Thai traditional medicine, the plant is included in formulas used in the form of decoctions, infusions, compresses, as well as in the form of ground pastes for external use. In the folk practices of the peoples of Malaysia, the leaves were used in the form of juice and chewing fresh, as well as a component of smoke mixtures for fumigating premises.

Ethnographic data record the use of Justicia gendarussa as a plant for ritual purification in some regions of Papua New Guinea, where its aromatic parts were burned in fires during ceremonies. In Indonesian culture, there was a belief that the plant has protective properties, and fresh branches could be placed at the entrance to the house for protection from evil spirits. In some parts of South India, the plant was used in ritual ceremonies associated with seasonal festivals, where leaves were included in offerings.

Written references to Justicia gendarussa are found in regional herbalists of India and Malaya beginning in the 17th–18th centuries, as well as in colonial botanical descriptions of the 19th century compiled by European researchers. In oral tradition, knowledge about the plant was passed down within family and professional communities of healers and shamans, and methods of use varied depending on the cultural and ecological context of the region.