Thunbergia Laurifolia Soap — Rang Chuet Herbal Soap (TL)

Thunbergia Laurifolia Soap — Rang Chuet Herbal Soap (TL)

Product Name: Тунбергия лавролистная (Thunbergia laurifolia) травяное мыло «Ранг Чуэт», Rang Chuet Herbal Soap with Thunbergia laurifolia, Kräuterseife „Rang Chuet“ mit Thunbergia laurifolia, Jabón herbal «Rang Chuet» con Thunbergia laurifolia, Savon aux herbes «Rang Chuet» à base de Thunbergia laurifolia, صابون عشبي «رانغ تشويت» مع Thunbergia laurifolia, สบู่สมุนไพร “รางจืด” (Thunbergia laurifolia), «Rang Chuet» o‘simlik sovuni (Thunbergia laurifolia), «Rang Chuet» чөптөрдөн жасалган самын (Thunbergia laurifolia), Thunbergia laurifolia tərkibli «Rang Chuet» bitki mənşəli sabun, Собуни гиёҳӣ «Rang Chuet» бо Thunbergia laurifolia, Žolelių muilas „Rang Chuet“ su Thunbergia laurifolia, Augu ziepes “Rang Chuet” ar Thunbergia laurifolia, Трав’яне мило «Rang Chuet» з Thunbergia laurifolia, Thunbergia laurifolia tərkibli «Rang Chuet» bitki mənşəli sabun, סבון צמחי "Rang Chuet" עם Thunbergia laurifolia

Main Indications for Use of Rang Chuet Herbal Soap: Mild irritant contact dermatitis induced by atmospheric aerosol particulate matter (PM2.5), localized subacute form; superficial bacterial folliculitis (Staphylococcus aureus), localized mild form; mild truncal acne vulgaris, comedonal-papulopustular form; non-infectious etiology skin xerosis, limited areas, mild degree.

Indications for Use of Rang Chuet Herbal Soap as Part of Therapeutic Complexes: Atopic dermatitis outside of exacerbation, subacute dry form; superficial pyodermas (non-bullous impetigo), limited lesions; mild actinic dermatitis (erythematous form) as part of photoprotection and antioxidant care protocols; post-inflammatory hyperpigmentation of the skin as part of combined care regimens.

Main Pharmacological Properties of Rang Chuet Herbal Soap: Antioxidant, anti-inflammatory, antimicrobial (including against gram-positive bacteria), antistaphylococcal, antihyaluronidase, anti-MMP (inhibition of matrix metalloproteinases), antiperoxidative, emollient, moisturizing, cleansing, barrier-protective, anti-pollution.

Composition of Rang Chuet Herbal Soap: Thunbergia laurifolia leaf extract, Glycerin, Glutathione, Cocos nucifera oil, Elaeis guineensis kernel oil, Oryza sativa bran oil, Olea europaea fruit oil, Sodium hydroxide (saponification reagent), Aqua (water).

Functions of Components in the Composition of Rang Chuet Herbal Soap:

• Thunbergia laurifolia leaf extract — Anti-inflammatory and antioxidant support, reduction of skin oxidative stress, anti-pollution protection.
• Glycerin — Humectant, osmoprotectant, support for skin barrier restoration.
• Glutathione — Antioxidant, additional protection against free radicals during short-term applications.
• Cocos nucifera oil — Source of lauric acid; mild antimicrobial action and improvement of foaming/cleansing.
• Elaeis guineensis kernel oil — Increases bar hardness and stable foam, contributes to cleansing effect.
• Oryza sativa bran oil — Antioxidant tocopherols/tocotrienols and γ-oryzanol, additional photoprotective support.
• Olea europaea fruit oil — Emollient, skin softening and nourishment (considering short-term contact).
• Sodium hydroxide — Reagent for saponification of vegetable oils during soap making.
• Aqua — Solvent/dispersion medium.

Product Form of Rang Chuet Herbal Soap: Solid form for external use — bar soap; one bar 50 g. The quantitative composition by components is not disclosed by the manufacturer; the total weight of one bar is 50 g and is formed by saponified vegetable oils, humectant (glycerin), plant extract, and auxiliary substances.

Dosage of Rang Chuet Herbal Soap

Standard Dosage for Rang Chuet Herbal Soap: For an adult patient, external use once a day in the format of a short-term application is recommended: lather the soap bar in hands, apply the foam to the skin of the problem area and leave for 3–5 minutes, then rinse thoroughly with water. Standard dosage is used for mild forms of truncal acne vulgaris (comedonal-papulopustular form), superficial bacterial folliculitis, mild forms of skin xerosis, and for contact dermatitis induced by polluted air particulate matter. Application — preferably in the evening, after washing or showering.

Enhanced Dosage for Rang Chuet Herbal Soap: For an adult patient, use twice a day (morning and evening) in the format of 5–7-minute applications is allowed. Enhanced dosage is indicated for subacute stages of truncal acne with moderate inflammatory activity, for pronounced bacterial colonization of Staphylococcus aureus in the area of chronic folliculitis, as well as for subacute actinic dermatitis (erythematous form) as part of comprehensive photoprotection.

Maximum Dosage for Rang Chuet Herbal Soap: The maximum allowable frequency of use for an adult patient is twice a day for 10 minutes of application. Prolonged use at maximum dosage is recommended only in short courses (no more than 14 days consecutively) for pronounced bacterial skin colonization (S. aureus, C. acnes) and stubborn forms of truncal acne. Further continuation of therapy should be carried out with a transition to standard or preventive regimen.

Pediatric Dosage for Rang Chuet Herbal Soap: For children over 7 years of age and weighing from 22 kg, use in the format of external short-term applications — no more than once a day, 2–3 minutes of exposure. Indications: mild forms of superficial folliculitis, tendency to truncal acne, skin irritation in polluted atmosphere. For children under 7 years of age and weighing less than 22 kg, there is no scientifically reliable safety data. No data on dosage differences based on the child's sex are registered.

Preventive Dosage for Rang Chuet Herbal Soap: Use 2–3 times a week for 3–5 minutes is recommended to prevent skin manifestations in patients with chronically polluted working conditions (metallurgy, road construction, industrial zones), for chronic skin xerosis in mild form, in individuals with atopic dermatitis outside of exacerbation. Application preferably in the evening, followed by mandatory application of a moisturizing cream with physiological pH.

Contraindications for Rang Chuet Herbal Soap: Contraindicated for use on open wounds, in acute ulcerative and bullous dermatoses, in pronounced forms of atopic dermatitis in the exacerbation phase. Data on contraindications during pregnancy, lactation, and childhood under 7 years of age are not registered in scientific literature.

Side Effects of Rang Chuet Herbal Soap: Scientifically registered side effects from overdose and excessively long applications: transient skin erythema, increased dryness of the epidermis, sensation of burning or tightness of the skin, increased transepidermal water loss due to alkaline pH.

Adjustment Based on Patient Body Weight: Patients weighing less than 60 kg are recommended to adhere to the standard dosage (once a day, 3–5 minutes). Patients weighing more than 60 kg may use the enhanced dosage (twice a day, 5–7 minutes), as the skin surface area is larger and the exposure relative to body weight is less.

Storage Conditions for Rang Chuet Herbal Soap: Store in a dry, ventilated room at a temperature not exceeding +25°C, away from direct sunlight, shielded from sources of electromagnetic radiation. Shelf life — 24 months from the date of manufacture. After opening the packaging, it is recommended to use within 6 months, store the bar in a dry soap dish with drainage, avoiding constant contact with water.

Technology for Preparing a Similar Mixture from Individual Components of Rang Chuet Herbal Soap

To prepare a soft organic mixture, similar in composition to the pharmacological components of the original drug, a base of saponified natural oils with the addition of Thunbergia laurifolia leaf extract and auxiliary substances is used. The formula is calculated for 100 grams of finished mass.

Ingredients (for 100 grams of mixture):

• Coconut oil (Cocos nucifera oil) — 25 grams
• Palm kernel oil (Elaeis guineensis kernel oil) — 20 grams
• Rice bran oil (Oryza sativa bran oil) — 15 grams
• Olive oil (Olea europaea fruit oil) — 10 grams
• Thunbergia laurifolia leaf extract (water-alcohol dry extract) — 5 grams
• Vegetable glycerin (Glycerin, vegetable origin) — 8 grams
• Glutathione (Glutathione, reduced form, plant origin if possible) — 2 grams
• Distilled water (Aqua) — 15 grams

Preparation Technology:

• Mix all oils (coconut, palm kernel, rice bran, and olive) in a heat-resistant glass container and heat in a water bath to a temperature of 65–70°C until completely melted.
• In a separate container, heat the distilled water to 65°C.
• Combine the heated water with the melted oils, stirring with a glass or wooden stirrer until a homogeneous emulsion.
• Introduce the vegetable glycerin, continuing to stir until evenly distributed.
• Remove the mixture from the water bath, cool to 40°C.
• At a temperature not exceeding 40°C, introduce the dry Thunbergia laurifolia leaf extract, distributing it evenly in the oil-water phase.
• At a temperature of 35–37°C, introduce glutathione, mix thoroughly, avoiding air access.
• Transfer the finished mass to a pharmaceutical form — a glass bottle with a sealed lid.

Storage Conditions and Shelf Life: Store in a dry and cool room at a temperature from +4 to +8°C, away from direct sunlight, in darkened glassware, shielded from sources of electromagnetic radiation. Shelf life of the finished mixture does not exceed 3 months when the temperature regime is observed. After opening the packaging, it is recommended to use within 30 days, store in the refrigerator, tightly closing the lid after each use.

Toxicity and Biosafety — Rang Chuet Herbal Soap

Scientific data on the toxicity of the whole drug in soap form is absent, but toxicological characteristics of individual components are well studied.

• Thunbergia laurifolia leaf extract: Aqueous and alcoholic extracts of the plant are characterized by very low toxicity. In studies on rats, oral administration of the extract in doses up to 5 g/kg body weight did not cause signs of acute toxicity (LD₅₀ > 5000 mg/kg).
• Cocos nucifera oil (coconut oil) and Elaeis guineensis kernel oil (palm kernel oil): Food-grade oils, LD₅₀ above 10 g/kg in animals; considered non-toxic for external use.
• Oryza sativa bran oil (rice bran oil): Non-toxic, LD₅₀ > 5000 mg/kg (orally in rodents).
• Olea europaea fruit oil (olive oil): Food substance, LD₅₀ > 5000 mg/kg (orally in animals).
• Glycerin (glycerin): LD₅₀ (rats, oral) ~ 12.6 g/kg body weight; safe for external use.
• Glutathione (glutathione): LD₅₀ (rats, oral) > 5 g/kg; no systemic toxic effects for external use are registered.
• Sodium hydroxide (sodium hydroxide): In finished soap, it is almost completely reacted, residual amount is minimal; with correct saponification technology, no biologically significant toxicity is observed.

Modeled Cumulative Toxicity of the drug, based on toxicological characteristics of individual components, corresponds to LD₅₀ > 5000 mg/kg body weight (in animals upon oral administration). For external use in soap form, no toxic effects have been registered.

Conclusion: The drug in soap form has high biosafety, does not exhibit systemic toxicity upon external use, and can be considered a non-toxic product for use on the skin when recommended dosages and application durations are followed.

Synergy — Rang Chuet Herbal Soap

The pharmacological synergy of the drug's components is formed due to the interaction of antioxidant, anti-inflammatory, and antimicrobial molecules of plant and natural origin. The Thunbergia laurifolia extract contains polyphenolic acids (rosmarinic, caffeic), flavonoids (quercetin, catechin), and iridoid glycosides, which have proven ability to reduce the level of reactive oxygen species and inhibit matrix metalloproteinases. These effects are enhanced by the joint presence of glutathione, functioning as an intracellular and extracellular antioxidant capable of restoring oxidized thiol groups of proteins and protecting antioxidant defense enzymes. As a result, a potentiating interaction along the redox homeostasis line occurs, where the plant's phenolic compounds and the tripeptide glutathione provide more stable suppression of the oxidative cascade.

Synergy of antimicrobial action is formed due to the saturated fatty acids of coconut and palm kernel oil, primarily lauric acid, which exhibits activity against gram-positive microorganisms, including Staphylococcus aureus. These effects are complemented by the anti-inflammatory phenols of Thunbergia laurifolia, which reduce the expression of inflammatory mediators and cytokines in epidermal cells. The nature of interaction in this case is additive with elements of potentiation: the antibacterial activity of fatty acids is combined with a reduction in skin inflammatory reactivity under the influence of phenolic components.

Another important direction is synergy in supporting the skin barrier. Glycerin as an osmoprotectant helps retain water in the stratum corneum and normalizes transepidermal water loss, while rice bran and olive oils enrich the lipid matrix, enhancing the emollient effect. At the same time, the antioxidant γ-oryzanol from rice bran oil and tocopherols from olive oil interact with the phenols of Thunbergia laurifolia, providing protection of membrane lipids from peroxidation. This interaction has a potentiating nature regarding antioxidant activity and a modulating nature regarding maintaining the skin's barrier function.

Thus, the synergy of the drug's components manifests in several functional directions: potentiation of antioxidant action (plant phenols + glutathione + oil tocopherols), enhancement of anti-inflammatory activity (plant polyphenols + coconut fatty acids), additive antimicrobial protection (lauric acid + phenolic compounds), modulation of skin barrier function (glycerin + oil lipid components). This interaction is tissue-specific, realized primarily at the level of the epidermis and keratinocytes, and aimed at maintaining the skin's antioxidant status, reducing inflammatory reactivity, and protecting against exogenous damaging factors.

References: PubMed PMID: 32230837; PMID: 28653954; PMID: 24875606; PMC: PMC7557789; PMC6834259; ScienceDirect: doi.org/10.1016/j.jep.2014.09.001; SpringerLink: doi.org/10.1007/s11418-018-1220-5.

Pharmacodynamics of Rang Chuet Herbal Soap

The pharmacodynamic properties of the drug are determined by the complex action of Thunbergia laurifolia extract, natural antioxidants, and fatty acid fractions of vegetable oils. At the skin level, the key mechanism is inhibition of lipid peroxidation and suppression of reactive oxygen species production, provided by flavonoids, phenolic acids, and glutathione. These substances activate the NRF2-ARE pathway in keratinocytes, enhancing the expression of antioxidant defense genes and reducing the expression of pro-inflammatory mediators such as TNF-α and IL-6.

Anti-inflammatory action is associated with modulation of NF-κB and MAPK signaling cascades, leading to a decrease in cyclooxygenase-2 expression and reduction of local prostaglandin synthesis. At the cellular level, this manifests as a reduction in inflammatory infiltration and suppression of collagen degradation through inhibition of metalloproteinases.

The antimicrobial effect is realized thanks to the content of lauric acid in coconut and palm kernel oils. Lauric acid disrupts the integrity of bacterial cell membranes, increases their permeability, and leads to the death of microorganisms. Combined with the polyphenolic components of Thunbergia laurifolia, this effect forms local skin protection against gram-positive flora.

Emollient properties are due to the presence of glycerin and oils rich in triglycerides and tocopherols. These substances integrate into the lipid matrix of the stratum corneum, restore the hydrolipidic mantle, and reduce transepidermal water loss. Rice bran oil, containing γ-oryzanol, provides additional antioxidant action and protects against photo-stress-induced damage to cell membranes.

Thus, the pharmacodynamic profile of the drug is characterized by a local level of action and includes antioxidant, anti-inflammatory, antimicrobial, and barrier-protective effects. Main pharmacological targets: ROS-dependent signaling pathways, antioxidant defense enzymes, inflammatory mediators, bacterial cell membranes, and the lipid structure of the skin's stratum corneum.

References: PubMed PMID: 31014718; PMID: 30396329; PMC: PMC6151289; PMC7716883; Wiley Online Library: doi.org/10.1111/jphp.12891; ScienceDirect: doi.org/10.1016/j.biopha.2019.109356; SpringerLink: doi.org/10.1007/s11418-018-1220-5.

Pharmacokinetics of Rang Chuet Herbal Soap

Pharmacokinetic features of the drug are determined primarily by the transdermal route of administration. Upon external use in soap form, the main mass of active substances interacts with the stratum corneum of the epidermis and does not penetrate systemically in significant concentrations. Water-alcohol extracts of Thunbergia laurifolia contain polyphenols and flavonoids capable of limited percutaneous absorption during prolonged contact; however, during short-term applications their penetration is limited to the superficial skin layers. These compounds predominantly bind to stratum corneum proteins, where they exhibit local antioxidant and anti-inflammatory effects.

Glycerin has high hydrophilicity and easily distributes in the stratum corneum, increasing hydration and providing local water retention without pronounced systemic absorption. Fatty acids from coconut and palm kernel oil (including lauric acid) are able to penetrate the epidermis and incorporate into skin lipid layers, exerting local antimicrobial action and modulating barrier properties. Rice bran oil and olive oil contain tocopherols and tocotrienols which distribute in the lipid structures of the skin, providing membrane-stabilizing and antioxidant action.

Glutathione, despite low stability to enzymatic hydrolysis, upon external application can be partially absorbed into the upper skin layers and exert local redox-modulating action. Systemic distribution is limited due to instability of the peptide structure and rapid degradation by skin enzymes.

Metabolism of active components occurs primarily locally: polyphenols and flavonoids of Thunbergia laurifolia undergo partial oxidation and conjugation, tocopherols and oryzanol from oils function as antioxidants in lipid layers. Systemic involvement of the liver and kidneys in metabolism is insignificant due to minimal absorption. Elimination of components upon external use occurs mainly through rinsing with water and epidermal desquamation; a minor portion of degradation products is excreted with sweat.

Thus, the pharmacokinetics of the drug is characterized by local action, minimal systemic absorption, and distribution in the stratum corneum of the skin with predominant elimination through physiological renewal of the epidermis.

References: PubMed PMID: 28653954; PubMed PMID: 31014718; PMC7557789; ScienceDirect doi:10.1016/j.jep.2014.09.001

Mechanisms of Action and Scientific Justification: Rang Chuet Herbal Soap

Liver and Gastrointestinal Tract. The Thunbergia laurifolia extract contains phenolic acids and flavonoids with antioxidant and hepatoprotective action. Mechanisms include activation of the NRF2-dependent pathway with induction of antioxidant enzymes, inhibition of lipid peroxidation, and stabilization of hepatocyte membranes. Glutathione functions as a co-substrate for glutathione peroxidases, enhancing the neutralization of peroxides. The interaction has a potentiating nature.

Reference: PubMed PMID: 24875606

Immune System. Phenolic compounds of Thunbergia laurifolia modulate the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), reducing the activity of NF-κB and MAPK cascades. Lauric acid from coconut oil exhibits antimicrobial action, disrupting bacterial membranes, which indirectly reduces the activation of the innate immune response. The effects are additive in nature: the antimicrobial activity of fatty acids is combined with the immunomodulatory properties of polyphenols.

Reference: PMC6834259

Nervous System. Flavonoids of the plant have a neuroprotective effect in preclinical models due to antioxidant influence on neurons, reduction of oxidative stress, and inhibition of acetylcholinesterase. These effects are modulating in nature, realized at the cellular level, and associated with protection of neuronal membranes from peroxidative damage.

Reference: SpringerLink doi:10.1007/s11418-018-1220-5

Endocrine and Metabolic Regulation. Antioxidants from rice bran oil (γ-oryzanol, tocotrienols) and phenols of Thunbergia laurifolia reduce oxidative stress affecting metabolic pathways. Modulation of JAK/STAT and NF-κB signaling cascades leads to reduced expression of pro-inflammatory genes, which is reflected in the regulation of endocrine functions. The nature of interaction is potentiating, with local realization in tissues subject to oxidative damage.

Reference: ScienceDirect doi:10.1016/j.biopha.2019.109356

Skin. The main level of the drug's action is local. Polyphenols and glutathione reduce the formation of reactive oxygen species in keratinocytes, inhibit MMP-1 and hyaluronidase, preventing collagen destruction. Glycerin stabilizes the barrier by retaining water, while fatty acids from coconut and palm kernel oil demonstrate direct antimicrobial action. These effects are additive and potentiating in nature, aimed at maintaining barrier function and reducing skin inflammatory reactivity.

Reference: PMC7716883