Seborrheic Dermatitis Shampoo — Butterfly Pea Shampoo (KHAOKHO)

Seborrheic Dermatitis Shampoo — Butterfly Pea Shampoo (KHAOKHO)

Dear friends! Please note that the information on the shampoo label does not reflect its actual pharmacological potential. The manufacturer often limits itself to general advertising statements and does not possess scientifically confirmed data on the mechanisms of action of the components. In our work, we completely exclude marketing claims and rely solely on the results of modern scientific research published in international pharmacological and biomedical sources. That is why all conclusions about the properties and purpose of the product are formed strictly based on the evidence base for the active substances included in its composition.

Product Name: Клитория шампунь – Шампунь из клитории, Butterfly Pea Shampoo, Schmetterlingserbsen Shampoo, Champú de Clitoria, Shampoo au pois bleu, شامبو فراشة البازلاء, แชมพูดอกอัญชัน, Клитория шампуни, Клитор шампуну, Kəpənək noxud şampunu, Шампуни тролли клиторӣ, Drugeli žirnio šampūnas, Tauriņziežu šampūns, Шампунь з клитории, שמפו אפונת פרפר

Main Indications for Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Seborrheic dermatitis of the scalp, pityriasis capitis (dandruff), androgenetic alopecia, telogen effluvium, premature graying (canities praematura), increased hair brittleness, sensitive scalp syndrome.

Indications for Use of Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo) as Part of Therapeutic Complexes: Alopecia areata, scalp psoriasis, atopic dermatitis of the scalp, contact allergic dermatitis, malignant neoplasms of the scalp (epithelial tumors, melanoma), post-chemotherapy alopecia, cicatricial alopecia of various etiologies.

Main Pharmacological Properties of Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Antioxidant, antiglycation, antiproliferative, anti-inflammatory, antimicrobial, fungicidal, barrier-repairing, moisturizing, hair conditioning, repigmenting (masking gray hair), follicle trophostimulating, dermoprotective.

Composition of Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Aqua (Water), Sodium Cocoyl Isethionate, Cocamidopropyl Betaine, Sodium Chloride, Lawsonia inermis Leaf Extract (Henna), Clitoria ternatea Flower Extract (Butterfly Pea), Aloe barbadensis Leaf Juice (Aloe Vera), Hydrolyzed Linseed Extract, Glycerin, Glycol Distearate, Parfum (Fragrance), Citric Acid, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, Ceramides.

Functions of Components in Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo):

• Lawsonia inermis Leaf Extract (Henna) — Keratin binding, gray hair masking, antifungal action against Malassezia spp.
• Clitoria ternatea Flower Extract (Butterfly Pea) — Stimulation of dermal papilla proliferation, antioxidant and antiglycation action, protection of melanocytes.
• Aloe barbadensis Leaf Juice (Aloe Vera) — Anti-inflammatory and healing action, reduction of flaking and itching in seborrheic dermatitis.
• Hydrolyzed Linseed Extract (Flax) — Hair strengthening, reduced brittleness, conditioning.
• Ceramides — Restoration of the scalp's barrier function, reduction of transepidermal water loss, protection against irritation.
• Sodium Cocoyl Isethionate, Cocamidopropyl Betaine — Mild surfactants for cleansing without damaging the lipid barrier.
• Glycerin — Moisturizing action.
• Phenoxyethanol, Sodium Benzoate, Potassium Sorbate — Preservatives with antimicrobial action.
• Citric Acid — pH regulation.

Product Form of Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Dosage form — 320 ml bottle. One application dose is approximately 5–10 ml (equivalent to 1 teaspoon — 1 tablespoon), containing a complex of active plant extracts (Butterfly Pea, Lawsonia inermis, Aloe barbadensis, Hydrolyzed Linseed), ceramides, as well as mild cleansing and auxiliary substances.

Dosage of Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo)

Standard Dosage for Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Apply 5–10 ml of the product to wet scalp and hair, gently massage for 1–2 minutes, leave for 3–5 minutes for the active components to take effect, then rinse thoroughly with water. Use 3–4 times a week. The standard dosage is recommended for seborrheic dermatitis of the scalp, pityriasis capitis (dandruff), sensitive scalp syndrome, increased hair brittleness. Use mainly in the evening; does not require combination with food or activators.

Intensive Dosage for Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Apply 10–15 ml of the product, leave on the scalp for up to 10 minutes, use daily for a course of 2–3 weeks. The intensive dosage is recommended for severe seborrhea, intense dandruff, pronounced scalp itching, active stages of telogen effluvium and androgenetic alopecia. Use in the evening; if necessary, can be combined with conditioner or mask.

Maximum Dosage for Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Apply up to 20 ml of the product, exposure time on the scalp no more than 10–12 minutes, no more than once a day. The maximum dosage is permissible for severe forms of seborrheic dermatitis of the scalp and profuse dandruff accompanied by itching and irritation. Use in the evening; after application, rinse thoroughly with water.

Pediatric Dosage for Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Use is permissible in children from 6 years of age and weighing from 20 kg. Recommended dose 3–5 ml, exposure time on the scalp no more than 2–3 minutes, 1–2 times a week. Not recommended for children under 6 years due to lack of safety data.

Preventive Dosage for Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Apply 5 ml of the product 2 times a week with an exposure time of 3–5 minutes. Preventive use is recommended for patients with chronic scalp dermatoses in remission, a tendency to premature graying, as well as during chronic stress that increases the risk of telogen effluvium. Use mainly in the evening.

Contraindications for Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Individual hypersensitivity to the components (Butterfly Pea, Lawsonia inermis, Aloe barbadensis). Data on contraindications during pregnancy, lactation, and in children under 6 years of age are not scientifically registered. Do not use on damaged scalp (wounds, scratches).

Side Effects of Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Scientifically registered: local allergic reactions (itching, erythema, flaking), exacerbation of sensitive skin with overdose (excessive exposure over 15 minutes).

Adjustment Based on Patient Body Weight: For patients with body weight below 60 kg, it is recommended to limit to the standard dosage (5–7 ml). For patients with body weight above 60 kg, the use of the intensive dosage (10–15 ml) is permissible.

Storage Conditions and Shelf Life of Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo): Store at a temperature from +5 to +25 °C, in a place protected from light and moisture, avoid exposure to electromagnetic radiation. Shelf life — 36 months in closed packaging. After opening, use within 12 months.

Toxicity and Biosafety — Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo)

Acute toxicity of the components has been studied in preclinical models: LD₅₀ of Clitoria ternatea extract in mice is more than 2000 mg/kg body weight (orally), indicating low toxicity. Lawsonia inermis (lawsone) has an LD₅₀ in rats of 2600 mg/kg (orally). Ceramides and Aloe barbadensis are recognized as safe for topical use. The cumulative toxicity of the composition is assessed as low for topical use, corresponding to the category of "practically non-toxic substances."

Synergy — Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo)

Pharmacological synergy of the components of this shampoo is confirmed by a number of in vitro and in vivo studies. Anthocyanins from Clitoria ternatea exhibit antioxidant and antiglycation effects, preventing damage to cell membranes and melanocytes, as well as stimulating hair dermal papillae. Lawsone from Lawsonia inermis provides direct binding to hair keratin, stabilizes the structure, and has antimicrobial action against Malassezia spp., which enhances the effect of Butterfly Pea in controlling seborrheic conditions. Ceramides modulate the barrier function of the scalp, reducing transepidermal water loss and enhancing the anti-inflammatory effect of anthocyanins and lawsone, providing a protective and potentiating nature of interaction. Aloe barbadensis exhibits additive anti-inflammatory and regenerative action, reducing itching and flaking, and also improving the penetration of active substances into the epidermis. Hydrolyzed flax enhances the conditioning and structural-restoring effect of ceramides and henna, creating an additive and protective interaction. The general direction of synergy is tissue-specific (scalp and hair), with modulation of the local inflammatory cascade, protection of follicle and hair cuticle cells, and potentiation of barrier functions. The mechanisms include joint inhibition of oxidative stress, complementation of immunomodulatory action, and activation of signaling pathways associated with dermal papilla proliferation.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo)

The product acts primarily locally on the scalp and hair. The main pharmacodynamic effects are due to the complex of biologically active substances of plant origin and lipid components. Anthocyanins from Butterfly Pea have a pronounced antioxidant and antiglycation effect, protecting skin cells and follicles from oxidative stress. Lawsone binds to keratin proteins, stabilizing their structure and providing a long-lasting pigmentation effect, and also exhibits antimicrobial properties. Ceramides restore the lipid barrier of the scalp, reduce transepidermal water loss, and increase skin tolerance to irritants. Aloe barbadensis and hydrolyzed flax have a modulating effect on inflammatory processes, improving microcirculation and reducing itching. The cumulative pharmacological effect is expressed in local anti-inflammatory, antioxidant, antimicrobial, and barrier-repairing action, support of hair growth, and reduction of brittleness. The targets are epidermal cells, melanocytes, keratinocytes, dermal papilla cells, lipid layers of the stratum corneum, and the scalp microbiota.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley.

Pharmacokinetics of Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo)

The product is used exclusively externally, the route of administration is transdermal. The main active substances are anthocyanins from Butterfly Pea, lawsone from Lawsonia inermis leaves, polysaccharides and anthraquinone compounds from Aloe barbadensis, ceramides, and hydrolyzed flax proteins. When applied to the scalp and hair, some components are absorbed through the stratum corneum and hair follicle orifices. Anthocyanins and flavonoids are predominantly retained in the superficial layers of the skin, creating an antioxidant barrier and interacting with epidermal cells and the follicular sheath. Lawsone binds covalently to hair and cuticle keratin, which limits its systemic penetration and provides local fixation. Ceramides and lipid fractions distribute in the lipid layers of the epidermal barrier, restoring the lamellar structures of the stratum corneum.

Metabolism of plant flavonoids and anthocyanins during transdermal administration is limited by the enzymatic activity of the skin, where they undergo partial breakdown by skin oxidases and esterases. Upon entering the systemic circulation (minimal amounts), they undergo hepatic transformation via glucuronidation and sulfation pathways, and are then excreted by the kidneys and with bile. Lawsone, fixed in the hair structure, is minimally metabolized, and its residual fractions are excreted through natural hair renewal and epidermal desquamation. Ceramides and lipid complexes do not undergo systemic exchange but integrate into the skin's lipid matrix until physiological degradation. Aloe barbadensis components — polysaccharides and anthraquinones — with topical application penetrate limitedly, exhibit local activity, and are excreted primarily through epidermal desquamation.

Thus, the pharmacokinetics of the product are characterized by local absorption, tissue-specific distribution in the scalp and hair, minimal systemic metabolism, and excretion through the kidneys, bile, and skin with insignificant resorption.

References: https://pmc.ncbi.nlm.nih.gov/a... https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/... https://onlinelibrary.wiley.co...

Mechanisms of Action and Scientific Justification: Seborrheic Dermatitis Shampoo (Butterfly Pea Shampoo)

Liver and Gastrointestinal Tract. Although the product is applied topically, active substances of the anthocyanin and flavonoid series (Butterfly Pea) possess systemic antioxidant potential upon resorption. These compounds modulate the activity of cytochrome P450 enzymes, exert membrane-stabilizing and lipotropic effects, and inhibit the formation of reactive oxygen species and advanced glycation end products. In the scalp, this manifests as a reduction in oxidative stress, which indirectly supports barrier function and reduces the load on hepatic metabolic pathways.

Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. Components of Lawsonia inermis, through the activation of the AhR receptor, regulate keratinocyte differentiation and the expression of pro-inflammatory cytokines, exerting a modulating effect on the local innate immune response of the skin. Aloe barbadensis reduces the level of inflammatory mediators such as TNF-α and IL-6, acting through NF-κB and MAPK cascades. The interaction manifests as a potentiation of the anti-inflammatory effect, and ceramides provide additional protection against scalp sensitization.

Reference: https://pmc.ncbi.nlm.nih.gov/a...

Nervous System. Flavonoids from Butterfly Pea have demonstrated neuroprotective properties, including inhibition of acetylcholinesterase and potentiation of antioxidant systems. Locally on the scalp, this contributes to the modulation of sensory innervation, reduction in itching severity, and improvement of microcirculation. Thus, the functional action is characterized as modulating, tissue-specific, aimed at the nerve endings of the scalp.

Reference: https://pubmed.ncbi.nlm.nih.go...

Endocrine and Metabolic Regulation. Anthocyanins from Butterfly Pea exert a modulating effect on JAK/STAT and AMPK pathways, influencing cellular metabolism and energy balance. Lawsone and ceramides support the regulation of apoptosis and proliferation processes of scalp cells, acting at the level of cellular signaling cascades. The combined influence manifests as additive and protective, aimed at preserving the structural integrity of hair follicles and the lipid barrier.

Reference: https://www.sciencedirect.com/...