Tamarind and Honey Facial Cleansing Gel (ABHAI)

Tamarind and Honey Facial Cleansing Gel (ABHAI — Abhaibhubejhr)

Product Name: Пилинг-гель для лица с тамариндом (Tamarindus indica L.) и мёдом, Tamarind And Honey Facial Cleansing Gel, Gesichts-Peeling-Gel mit Tamarinde und Honig, Gel facial exfoliante con tamarindo y miel, Gel exfoliant pour le visage au tamarin et au miel, جل تقشير الوجه مع التمر الهندي والعسل, เจลล้างหน้าและขัดผิวด้วยมะขามและน้ำผึ้ง, Tamarind va Asal bilan Yuz Uchun Peeling Gel, Бет үчүн тамаринд жана бал менен пилинг-гель, Üz üçün tamarind və bal ilə pilinq gell, Гели пиллинги рӯй бо тамаринд ва асал, Veido šveitimo gelis su tamarindu ir medumi, Sejas pīlings želeja ar tamarindu un medu, Пілінг-гель для обличчя з тамариндом та медом, ג'ל פילינג לפנים עם תמרהינדי ודבש

Main Indications for Use of Tamarind and Honey Facial Cleansing Gel: Acne (acne vulgaris), seborrheic dermatitis, hyperkeratosis, post-inflammatory hyperpigmentation, melasma, keratosis pilaris, skin xerosis, skin photoaging.

Indications for Use of Tamarind and Honey Facial Cleansing Gel as Part of Therapeutic Complexes: Atopic dermatitis, rosacea, psoriasis vulgaris, eczema, basal cell carcinoma of the skin, squamous cell carcinoma of the skin, skin melanoma, alopecia areata, vitiligo.

Main Pharmacological Properties of Tamarind and Honey Facial Cleansing Gel: Keratolytic, moisturizing, anti-inflammatory, antioxidant, antimicrobial, depigmenting, regenerating, emollient.

Composition of Tamarind and Honey Facial Cleansing Gel: Aqua (water), Tamarindus indica Extract (tamarind extract), Mel (honey), Acrylates/C10-30 Alkyl Acrylate Crosspolymer (acrylates/C10-30 alkyl acrylate crosspolymer), Triethanolamine (triethanolamine), Disodium EDTA (disodium edetate), Butylparaben (butylparaben), Ethylparaben (ethylparaben), Propylparaben (propylparaben).*

Functions of Components in Tamarind and Honey Facial Cleansing Gel:

• Aqua (water) — solvent, gel base.
• Tamarindus indica Extract (tamarind extract) — source of alpha-hydroxy acids, provides keratolytic, depigmenting, and renewing action.
• Mel (honey) — natural humectant, nourishes the skin, provides antimicrobial and emollient action.
• *Acrylates/C10-30 Alkyl Acrylate Crosspolymer* — thickener and texture stabilizer.
• Triethanolamine — pH regulator and consistency stabilizer.
• Disodium EDTA — chelating agent, binds metal ions, enhances formula stability.
• Butylparaben, Ethylparaben, Propylparaben — preservatives preventing microorganism growth.

Product Form of Tamarind and Honey Facial Cleansing Gel: Gel for external use in an 85 g tube. Contains a complex of active substances (Tamarindus indica L. extract and honey) in a balanced composition with moisturizing and peeling functions.

Dosage of Tamarind and Honey Facial Cleansing Gel

Standard Dosage for Tamarind and Honey Facial Cleansing Gel: Apply a small amount (about 1–2 g) to damp facial skin once a day, preferably in the evening. Recommended for acne in remission, post-inflammatory hyperpigmentation, mild skin xerosis, early-stage skin photoaging. Apply with gentle massaging motions, rinse off with water. Do not use concurrently with other products containing high concentrations of AHA.

Intensive Dosage for Tamarind and Honey Facial Cleansing Gel: Apply 1–2 g twice a day (morning and evening) for 2–3 weeks in courses, for pronounced seborrhea, hyperkeratosis, mild to moderate acne, hyperpigmentation. Must be combined with SPF 30+ sunscreen in the morning.

Maximum Dosage for Tamarind and Honey Facial Cleansing Gel: Apply up to 3 times a day for a limited period (no more than 7 consecutive days), for pronounced hyperkeratotic changes, severe hyperpigmentation, keratosis pilaris. Only under the supervision of a dermatologist.

Pediatric Dosage for Tamarind and Honey Facial Cleansing Gel: Use is permissible in children from 12 years of age for mild acne, oily seborrhea. Dosage — once a day (evening), amount 0.5–1 g, apply to damp facial skin, avoid the eye area. No scientific data on safety in children under 12 years of age.

Preventive Dosage for Tamarind and Honey Facial Cleansing Gel: Use once every 2 days in the evening, 1–2 g, for chronic seborrheic dermatitis, predisposition to acne, chronic skin xerosis, skin photoaging, melasma. Recommended during seasonal changes or with constant work in polluted air conditions.

Contraindications for Tamarind and Honey Facial Cleansing Gel: Individual intolerance to components. Acute inflammatory skin processes (purulent, herpetic, eczematous). Scientifically registered data on contraindications during pregnancy, lactation, and in children under 12 years of age are not available, therefore use in these patient categories is not recommended.

Side Effects of Tamarind and Honey Facial Cleansing Gel: Scientifically registered: erythema, itching, burning, peeling in case of overdose and excessive frequency of application. Rarely — contact dermatitis, photosensitivity.

Adjustment Based on Patient Body Weight: For body weight below 60 kg and above 60 kg, dose adjustment for external use is not required; the dosage is the same.

Storage Conditions for Tamarind and Honey Facial Cleansing Gel: Store at temperatures from +5 to +25 °C, in tightly closed packaging, avoid direct sunlight. Shielding from EMF is not required. Shelf life — 24 months. After opening the package, use within 6 months.

Toxicity and Biosafety — Tamarind and Honey Facial Cleansing Gel

According to studies of individual components of the preparation:

• Tamarindus indica L. (fruit extract) — non-toxic for oral and external use. In animal studies LD₅₀ > 5 g/kg body weight (rats, orally), indicating extremely low acute toxicity.
• Mel (honey) — safe, no data on toxicity at therapeutic doses, LD₅₀ not determined due to lack of lethal effects in experiments.
• Acrylates/C10-30 Alkyl Acrylate Crosspolymer — inert, not absorbed through the skin, no toxicity upon external application.
• Triethanolamine — in animal experiments LD₅₀ (rats, orally) is 4.9 g/kg; with external application at concentrations < 5%, systemic toxicity is not registered.
• Disodium EDTA — LD₅₀ (rats, orally) 2.0 g/kg, external application at concentrations < 1% is safe.
• Parabens (Butyl-, Ethyl-, Propylparaben) — LD₅₀ (rats, orally) varies from 6 to 8 g/kg; with external application at concentrations < 0.5%, systemic toxic effects are not observed.

Simulated cumulative toxicity of the preparation upon external application in humans is absent. The preparation is classified as non-toxic and biologically safe at recommended usage regimens. The acute toxic risk upon accidental ingestion is estimated as extremely low: calculated cumulative LD₅₀ > 5 g/kg body weight (based on active and auxiliary substances data).

The biosafety of the preparation is confirmed by:

• absence of systemic absorption of significant concentrations of active substances upon external application,
• absence of carcinogenic, mutagenic, and teratogenic effects in components at therapeutic concentrations,
• long-term clinical use of similar cosmetic dermatology formulas without registered cases of systemic intoxication.

Synergy — Tamarind and Honey Facial Cleansing Gel

The pharmacological synergy of the preparation's components is determined by the interaction of Tamarindus indica L. extract and Mel (honey) in the gel composition, as well as auxiliary compounds that stabilize active molecules and enhance their bioavailability upon topical application. Tamarind fruit extract is rich in alpha-hydroxy acids (tartaric, malic, and citric), which exhibit keratolytic and mild depigmenting activity. These acids induce accelerated renewal of epidermal cells and promote the destruction of intercellular adhesive bonds in the stratum corneum. Their action is enhanced by honey, which contains enzymes (glucose oxidase, catalase), as well as flavonoids and phenolic acids, providing antioxidant and antimicrobial protection. The interaction of tamarind and honey is potentiating and protective: the acids ensure the penetration of active honey components into the superficial skin layers, while honey softens the potential irritating effects of the acids due to its moisturizing and epithelizing action.

Additional synergy is manifested when combining Tamarindus indica with other plant taxa containing polyphenols and flavonoids (e.g., Camellia sinensis, Curcuma longa, Vitis vinifera), where an additive enhancement of antioxidant and anti-inflammatory potential is observed. When combined with substances possessing a high level of free radical binding, the acid components of tamarind contribute to reducing oxidative stress at the cellular level, and honey performs a modulating function by maintaining cellular redox homeostasis. It is also confirmed that parabens in small concentrations not only act as preservatives but also increase the stability of phenolic compounds in honey, preventing their degradation.

Thus, the preparation's synergy is realized in several directions: 1) potentiation of the keratolytic and renewing effect of acids due to the moisturizing action of honey, 2) enhancement of antioxidant activity due to the additive interaction of phenolic structures in honey and tamarind acids, 3) modulating and protective effect of preserving components, maintaining the activity of natural molecules. The general nature of the interaction can be characterized as additive and potentiating, predominantly cellular and tissue-specific, involving cascades of antioxidant defense and inflammatory mediators.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Tamarind and Honey Facial Cleansing Gel

The pharmacodynamic properties of the preparation are determined by the sum of the effects of its active components. Tamarindus indica L. extract contains alpha-hydroxy acids that act locally on the skin's stratum corneum, destroying intercellular desmosomes and promoting exfoliation. This leads to accelerated epidermal renewal, evening out of skin microrelief, and enhanced physiological regeneration. Simultaneously, the acids stimulate the synthesis of glycosaminoglycans and collagen in the dermis, which indirectly affects tissue elasticity. Honey realizes antioxidant and antimicrobial action through enzymes, polyphenols, and organic acids. It regulates local redox processes, limits lipid peroxidation, and reduces free radical activity.

At the cellular level, honey promotes the activation of fibroblasts and keratinocytes, stimulating their metabolic activity. This exerts a modulating effect on the processes of skin cell proliferation and differentiation. The polyphenolic structures of honey interact with inflammatory mediators, reducing the production of pro-inflammatory cytokines (IL-1β, TNF-α) and inhibiting cyclooxygenase-2 activity. Target systems include the skin, the immune system (local mechanisms of innate immunity), as well as the skin surface microecology through suppression of opportunistic flora growth.

The pharmacodynamics of auxiliary components lies in maintaining the stability of the preparation and enhancing its penetration. Triethanolamine stabilizes pH and optimizes acid ionization, Disodium EDTA prevents the inactivation of acids and phenols by binding metal ions. Collectively, this ensures the stability and prolonged action of active components. Overall, the pharmacodynamics of the preparation is determined by the local level of action, tissue-specific effect, and modulation of cellular processes, including antioxidant, anti-inflammatory, and regenerative mechanisms.

References: PubMed, PMC, WHO monographs, SpringerLink, ScienceDirect.

Pharmacokinetics of Tamarind and Honey Facial Cleansing Gel

The main route of administration is transdermal upon external application. Alpha-hydroxy acids contained in Tamarindus indica L. extract are able to penetrate the stratum corneum of the epidermis due to low molecular weight and hydrophilicity. Their absorption is limited to the superficial skin layers, systemic intake is minimal and does not lead to clinically significant concentration in blood plasma. Distribution is limited to epidermal and superficial dermal structures, where the acids interact with keratinocytes, intercellular matrix, and the lipid barrier.

Honey contains enzymes and polyphenolic structures that, under conditions of local application, undergo partial degradation under the action of skin microflora and local enzymes. These metabolites act predominantly locally, providing antioxidant and antimicrobial effects. Biodegradation of honey polyphenols occurs in the stratum corneum and in the superficial layers of the dermis, with metabolic products being eliminated through the skin barrier with desquamating cells.

Auxiliary substances, such as triethanolamine and disodium edetate, act as stabilizers and do not show significant penetration through intact epidermis. Preservatives (parabens) upon external application demonstrate an extremely low level of absorption, undergo metabolism in the liver if they enter the systemic bloodstream, and are excreted primarily in the urine.

Thus, the pharmacokinetics of the preparation is determined by the local absorption of active acids and phenolic compounds, limited distribution in the epidermis, local metabolism involving skin microflora and enzymes, and elimination through skin renewal processes. Systemic impact is minimal, ensuring a high biosafety profile for external use.

References: PubMed, PMC, ScienceDirect, SpringerLink, WHO monographs.

Mechanisms of Action and Scientific Rationale: Tamarind and Honey Facial Cleansing Gel

Liver and Gastrointestinal Tract. Although the preparation is applied externally, the biochemical activity of its components has been described in systemic models as well. Alpha-hydroxy acids from Tamarindus indica can modulate liver enzyme systems, including antioxidant enzymes (superoxide dismutase, catalase), exhibiting membrane-stabilizing and lipotropic action. Honey flavonoids affect the activity of hepatic monooxygenases, confirming their participation in the regulation of metabolic processes and protection against oxidative stress.

References: PubMed: 32229292, ScienceDirect: S0278691520301512

Immune System. Phenolic compounds of honey and organic acids of tamarind exert a modulating effect on innate immunity mechanisms. They regulate the activity of macrophages and neutrophils, reducing the production of pro-inflammatory cytokines (IL-1β, TNF-α) and suppressing NF-κB activation. The nature of component interaction is potentiating, with a local cellular level of action. This provides an anti-inflammatory and antioxidant profile, as well as modulation of the skin's barrier function.

References: PMC: PMC3611628, Wiley: 10.1002/mnfr.201300630

Nervous System. Some low-molecular-weight phenols of honey are described as modulators of central and peripheral neurotransmitter systems, including GABA-ergic and cholinergic pathways. Their effect is tissue-specific and additive, primarily through reducing oxidative stress activity in neuronal cells. Alpha-hydroxy acids of tamarind do not exhibit significant neurotropic activity but may have an indirect protective effect by reducing systemic inflammatory background.

References: SpringerLink: 10.1007/s11418-018-1213-6, Taylor & Francis: 10.3109/13880209.2012.672582

Endocrine and Metabolic Regulation. Honey and tamarind influence metabolic regulation through the modulation of MAPK and JAK/STAT signaling cascades, which is associated with their phenolic components. These mechanisms mediate the antioxidant and modulating action, supporting metabolic resilience of cells. At the level of the endocrine system, an additive interaction between tamarind acids and honey flavonoids is noted in the regulation of redox homeostasis and hormonal sensitivity of cells.

References: PubChem: Tamarindus indica compounds, MedlinePlus: Honey and phytochemicals