Impatiens balsamina L

Impatiens balsamina L

Product Name: Недотрога бальзаминовая, Impatiens balsamina, Balsamine, Bálsamo, Impatiente, بلسم, เทียนบ้าน, Balsamin, Бальзамин, Balsamin, Балсамин, Impatients, Balsamin, בלסמין

Synonyms: недотрога садовая, бальзамин садовый, garden balsam, rose balsam, touch-me-not, Garten-Balsamine, Balsamina de jardín, Impatiente du jardin, البلسم الوردي, เทียนสวน

Parts Used: leaves, stems, flowers, seeds, roots.

Main indications for use of Impatiens balsamina: dermatophytosis, skin mycosis, candidiasis, eczema, psoriasis, pyoderma, acne vulgaris, skin burns, inflammation of the oral mucosa, pharyngitis, tonsillitis, osteoarthritis, gout, cystitis, urethritis, nephritis, arterial hypertension, cough, bronchitis, rheumatism, helminthiasis.

Use of Impatiens balsamina in mixtures and complexes: chronic obstructive pulmonary disease, pulmonary tuberculosis, inflammatory diseases of the pelvic organs, chronic gastritis, intestinal dysbiosis, gastric ulcer, atherosclerosis, chronic heart failure, type 2 diabetes mellitus, osteoporosis, viral hepatitis.

Pharmacological properties of Impatiens balsamina: anti-inflammatory, antimicrobial, antifungal, antiviral, antiparasitic, antioxidant, immunomodulatory, wound healing, analgesic, hypotensive, diuretic, expectorant, antirheumatic, spasmolytic, cytotoxic, antitumor.

Dosage of pharmaceutical forms — Impatiens balsamina

Powder — Impatiens balsamina

Indications (Powder): dermatophytosis, skin mycosis, cutaneous candidiasis, eczema, psoriasis, pyoderma, acne vulgaris, skin burns, inflammation of the oral mucosa, pharyngitis, tonsillitis, osteoarthritis, gout, cystitis, urethritis, nephritis, arterial hypertension, cough, bronchitis, rheumatism, helminthiasis.

Standard Dosage (Powder): orally, 1 gram 2 times a day after meals; externally, as a powder on the affected area 1–2 times a day.

Enhanced Dosage (Powder): orally, 1.5 grams 2 times a day for acute fungal skin infections, pyoderma, severe cutaneous candidiasis.

Maximum Dosage (Powder): orally, up to 2 grams 2 times a day for no more than 5 days for pronounced skin inflammation and severe bacterial complications.

Preventive Dosage (Powder): orally, 0.5 grams 1 time a day, course 10 days every 2 months, for chronic fungal skin infections, in patients with immunodeficient conditions.

Pediatric Dosage (Powder): orally from 7 years of age with weight from 25 kg — 0.3 grams 2 times a day; externally, as a powder from 3 years of age.

Contraindications (Powder): individual intolerance, severe renal failure; no scientifically documented contraindications during pregnancy, lactation, and in childhood.

Side Effects (Powder): in case of overdose — nausea, diarrhea, irritation of mucous membranes.

Adjustment for Patient Body Weight (Powder): for body weight less than 60 kg, reduce dosage by 25%; for body weight more than 90 kg, increase dosage by 25%.

Preparation method (Powder): for 100 grams of product, take 100 grams of dried plant flowers, grind to a powder state in a mill with a 0.5 mm sieve, sieve, package in airtight containers. Without the use of solvents.

Storage Conditions and Shelf Life (Powder): store in tightly closed containers in a dry dark place at a temperature of 5 to 25 °C, avoid exposure to direct sunlight and electromagnetic radiation, shelf life is 2 years, after opening use within 6 months.

Dry Extract — Impatiens balsamina

Indications (Dry Extract): dermatophytosis, skin mycosis, cutaneous candidiasis, eczema, psoriasis, pyoderma, acne vulgaris, skin burns, inflammation of the oral mucosa, pharyngitis, tonsillitis, osteoarthritis, gout, cystitis, urethritis, nephritis, arterial hypertension, cough, bronchitis, rheumatism, helminthiasis.

Standard Dosage (Dry Extract): orally, 0.2 grams 2 times a day after meals; externally, as powders or addition to cream at 5% concentration.

Enhanced Dosage (Dry Extract): orally, 0.3 grams 2 times a day for acute bacterial and fungal skin infections.

Maximum Dosage (Dry Extract): orally, 0.4 grams 2 times a day for up to 5 days for severe skin infections with inflammation.

Preventive Dosage (Dry Extract): orally, 0.1 grams 1 time a day in courses of 14 days every 3 months for recurrent mycoses.

Pediatric Dosage (Dry Extract): orally from 7 years of age, 0.05 grams 2 times a day with weight from 25 kg.

Contraindications (Dry Extract): individual intolerance, acute renal failure; no scientifically documented contraindications during pregnancy, lactation, and in childhood.

Side Effects (Dry Extract): in case of overdose — dyspepsia, skin rash.

Adjustment for Patient Body Weight (Dry Extract): for body weight less than 60 kg, reduce dose by 20%; for body weight more than 90 kg, increase dose by 20%.

Preparation method (Dry Extract): take 500 grams of dry flowers, grind, perform extraction with 70% ethanol (for extraction only) in a raw material/solvent ratio of 1:10 for 48 hours at a temperature not exceeding 30 °C, filter, evaporate in a water bath at a temperature not exceeding 50 °C to a dry residue, completely remove the ethanol odor, residual ethanol content not more than 500 ppm, grind the dry residue, package in airtight containers.

Storage Conditions and Shelf Life (Dry Extract): store in a dry dark place at a temperature of 5 to 25 °C, avoid exposure to direct sunlight and EMI, shelf life is 3 years, after opening use within 12 months.

Tincture — Impatiens balsamina

Indications (Tincture): dermatophytosis, skin mycosis, cutaneous candidiasis, eczema, psoriasis, pyoderma, acne vulgaris, skin burns, inflammation of the oral mucosa, pharyngitis, tonsillitis, osteoarthritis, gout, cystitis, urethritis, nephritis, arterial hypertension, cough, bronchitis, rheumatism, helminthiasis.

Standard Dosage (Tincture): orally, 10 drops 2 times a day; externally, for skin treatment 1–2 times a day.

Enhanced Dosage (Tincture): orally, 15 drops 2 times a day for acute inflammatory skin processes and pronounced bacterial complications.

Maximum Dosage (Tincture): orally, up to 20 drops 2 times a day, no more than 7 days in a row, for severe skin infections with a purulent component.

Preventive Dosage (Tincture): orally, 5 drops 1 time a day for a course of 10 days every 2 months for chronic fungal skin infections.

Pediatric Dosage (Tincture): orally from 12 years of age, 3 drops 2 times a day, with weight from 40 kg.

Contraindications (Tincture): individual intolerance, chronic alcoholism, epilepsy, severe liver failure; no scientifically documented contraindications during pregnancy, lactation, and in children under 12 years of age.

Side Effects (Tincture): in case of overdose — dizziness, nausea, palpitations.

Adjustment for Patient Body Weight (Tincture): for body weight less than 60 kg, reduce dose by 20%; for body weight more than 90 kg, increase by 20%.

Preparation method (Tincture): for 100 grams of finished product, take 20 grams of dry plant flowers, grind, pour 80 milliliters of 40% ethyl alcohol (ethanol is used for extraction only), infuse in a dark place at a temperature of 20–25 °C for 14 days, shaking periodically, filter, if necessary, bring the volume to 100 ml with purified water, package in dark glass vials. Residual ethanol content meets pharmacopoeial standards.

Storage Conditions and Shelf Life (Tincture): store in tightly closed dark glass vials at a temperature of 5 to 25 °C, away from heat and light sources, shelf life is 3 years, after opening use within 6 months.

Cream — Impatiens balsamina

Indications (Cream): dermatophytosis, skin mycosis, cutaneous candidiasis, eczema, psoriasis, pyoderma, acne vulgaris, skin burns, inflammation of the oral mucosa, osteoarthritis, gout, rheumatism.

Standard Dosage (Cream): apply a thin layer to the affected area of skin 2 times a day.

Enhanced Dosage (Cream): apply 3 times a day for pronounced inflammatory reactions and itching.

Maximum Dosage (Cream): up to 4 times a day for no more than 10 days for acute inflammation with bacterial complications.

Preventive Dosage (Cream): apply 1 time a day in courses of 7 days each month in patients with chronic recurrent skin mycosis.

Pediatric Dosage (Cream): use from 3 years of age 1–2 times a day on small areas of skin.

Contraindications (Cream): individual intolerance, deep purulent wounds, extensive burns of II–III degree; no scientifically documented contraindications during pregnancy, lactation, and in children under 3 years of age.

Side Effects (Cream): in case of overdose — skin irritation, contact dermatitis.

Adjustment for Patient Body Weight (Cream): not required, as the form is for external use.

Preparation method (Cream): for 100 grams of finished cream, take 10 grams of dry extract of plant flowers, 50 grams of coconut oil, 35 grams of beeswax, 5 grams of shea butter. Melt the coconut oil and wax in a water bath at a temperature not exceeding 50 °C, add shea butter, mix, add the dry extract, thoroughly emulsify until a homogeneous mass is obtained, cool at room temperature, package in opaque jars.

Storage Conditions and Shelf Life (Cream): store in tightly closed containers at a temperature of 5 to 20 °C, in a dark place, shelf life is 12 months, after opening use within 3 months.

Ointment — Impatiens balsamina

Indications (Ointment): dermatophytosis, skin mycosis, cutaneous candidiasis, eczema, psoriasis, pyoderma, acne vulgaris, skin burns, osteoarthritis, gout, rheumatism.

Standard Dosage (Ointment): apply a thin layer to the affected area 2 times a day.

Enhanced Dosage (Ointment): apply 3 times a day for pronounced inflammatory changes and pain syndrome.

Maximum Dosage (Ointment): apply up to 4 times a day for 7–10 days for acute inflammation with a bacterial component.

Preventive Dosage (Ointment): apply 1 time a day in courses of 5–7 days every 2 months in patients with chronic skin mycosis and recurrent dermatitis.

Pediatric Dosage (Ointment): use from 3 years of age, apply 1–2 times a day to a small area of skin.

Contraindications (Ointment): individual intolerance, deep purulent wounds, extensive burns of II–III degree; no scientifically documented contraindications during pregnancy, lactation, and in children under 3 years of age.

Side Effects (Ointment): in case of overdose — skin irritation, contact dermatitis.

Adjustment for Patient Body Weight (Ointment): not required, as the form is for external use.

Preparation method (Ointment): for 100 grams of finished ointment, take 15 grams of plant flower powder, 60 grams of coconut oil, 20 grams of beeswax, 5 grams of lanolin. Melt the coconut oil and wax in a water bath at a temperature not exceeding 50 °C, add lanolin, mix thoroughly, add the plant powder, mix until a homogeneous mass is obtained, cool, package in dark glass jars.

Storage Conditions and Shelf Life (Ointment): store in airtight dark glass containers at a temperature of 5 to 20 °C, away from direct light and heat sources, shelf life is 12 months, after opening use within 3 months.

Cosmetics (extract for cosmetic products) — Impatiens balsamina

Indications (Cosmetics): acne vulgaris, seborrheic dermatitis, eczema, psoriasis, atopic dermatitis, skin inflammation, hyperpigmentation, skin photoaging, dry skin.

Standard Dosage (Cosmetics): add to creams, lotions, serums at a concentration of 1–3%.

Enhanced Dosage (Cosmetics): up to 5% in cosmetic products for pronounced hyperpigmentation and seborrheic dermatitis.

Maximum Dosage (Cosmetics): up to 7% in spot application serums for intense inflammatory elements of acne.

Preventive Dosage (Cosmetics): 1% in moisturizing cream for the prevention of dry skin and inflammation, use in courses of 14 days every 2–3 months.

Pediatric Dosage (Cosmetics): use is allowed from 7 years of age at a concentration of not more than 1% in cosmetic creams and lotions.

Contraindications (Cosmetics): individual intolerance; no scientifically documented contraindications during pregnancy, lactation, and in children under 7 years of age.

Side Effects (Cosmetics): in case of overdose in cosmetic products — skin irritation, dryness, redness.

Adjustment for Patient Body Weight (Cosmetics): not required.

Preparation method (Cosmetics): for 100 grams of extract, take 200 grams of dry plant flowers, grind, perform extraction with 50% ethanol (ethanol is used for extraction only) in a ratio of 1:5 for 72 hours at a temperature not exceeding 30 °C, filter, evaporate in a water bath at a temperature not exceeding 50 °C to obtain a thick concentrate, remove the ethanol odor, residual content not more than 500 ppm. Use the resulting extract as an active ingredient in cosmetics.

Storage Conditions and Shelf Life (Cosmetics): store in airtight dark glass containers at a temperature of 5 to 20 °C, in a dry place, shelf life is 2 years, after opening use within 6 months.

Serum — Impatiens balsamina

Indications (Serum): acne vulgaris, seborrheic dermatitis, atopic dermatitis, hyperpigmentation, skin photoaging, dry skin, skin inflammation, post-acne.

Standard Dosage (Serum): apply to cleansed skin 1–2 times a day at an active extract concentration of 1–3%.

Enhanced Dosage (Serum): up to 5% for pronounced hyperpigmentation and active inflammatory eruptions.

Maximum Dosage (Serum): up to 7% for spot application on intense inflammatory elements of acne or hyperpigmented areas.

Preventive Dosage (Serum): 1% extract in serum, apply 1 time a day at night in courses of 14 days every 2–3 months for a tendency to acne and dry skin.

Pediatric Dosage (Serum): use is allowed from 12 years of age at a concentration of not more than 1% and only for a tendency to skin inflammation.

Contraindications (Serum): individual intolerance; no scientifically documented contraindications during pregnancy, lactation, and in children under 12 years of age.

Side Effects (Serum): in case of overdose — skin irritation, burning sensation, dryness.

Adjustment for Patient Body Weight (Serum): not required.

Preparation method (Serum): for 100 grams of serum, take 2 grams of dry flower extract, 80 grams of chamomile hydrolate, 15 grams of aloe vera gel, 3 grams of glycerin. Mix the hydrolate with glycerin, add aloe vera gel, add the dry extract, stir until homogeneous, pour into bottles with a dispenser. Without heating above 30 °C, without the use of synthetic preservatives, store in a refrigerator.

Storage Conditions and Shelf Life (Serum): store in airtight bottles at a temperature of 5 to 8 °C, in a dark place, shelf life is 3 months, after opening use within 30 days.

Paste / Compress — Impatiens balsamina

Indications (Paste / Compress): dermatophytosis, skin mycosis, cutaneous candidiasis, eczema, psoriasis, pyoderma, skin burns, inflammation of joints in osteoarthritis, gout, rheumatism.

Standard Dosage (Paste / Compress): apply to the affected area of skin in a thick layer of paste or as part of a compress for 30–40 minutes 1–2 times a day.

Enhanced Dosage (Paste / Compress): apply 2–3 times a day for acute skin inflammation or pronounced joint pain syndrome.

Maximum Dosage (Paste / Compress): up to 4 times a day for severe inflammatory processes of the skin and joints, no more than 5 days in a row.

Preventive Dosage (Paste / Compress): apply 1 time a day for 5 days every 2 months in patients with chronic recurrent dermatitis or gout.

Pediatric Dosage (Paste / Compress): allowed from 6 years of age, apply 1 time a day to limited areas of skin.

Contraindications (Paste / Compress): individual intolerance, deep purulent wounds, extensive burns of II–III degree; no scientifically documented contraindications during pregnancy, lactation, and in children under 6 years of age.

Side Effects (Paste / Compress): in case of overdose — skin irritation, hyperemia.

Adjustment for Patient Body Weight (Paste / Compress): not required, as the form is for external use.

Preparation method (Paste / Compress): for 100 grams of paste, take 50 grams of fresh plant flowers, grind into a mush, mix with 30 grams of coconut oil and 20 grams of beeswax melted in a water bath at a temperature not exceeding 50 °C, stir until a homogeneous mass is obtained, cool. For the compress, apply the paste to a fabric base, apply to the skin and secure.

Storage Conditions and Shelf Life (Paste / Compress): store in airtight containers in a refrigerator at a temperature of 5 to 8 °C, in a dark place, shelf life is 1 month, after opening use within 7 days.

Toxicity and biosafety — Impatiens balsamina

Toxicity studies have shown that extracts of Impatiens balsamina flowers and leaves have low acute toxicity. In experimental models on mice and rats, it was determined that oral administration of the ethanolic extract did not cause lethal outcomes at doses up to 2000 mg/kg body weight, indicating an LD₅₀ above this level. Local use of plant-based preparations did not lead to systemic toxic reactions, but at high concentrations and with prolonged contact, the development of local skin irritation is possible. Data on chronic toxicity and carcinogenic potential are limited, but existing studies have not revealed significant mutagenic or teratogenic effects at the tested doses.

Reference: https://biointerfaceresearch.c...

Pharmacodynamics — Impatiens balsamina

The pharmacodynamic action of Impatiens balsamina is due to a complex of biologically active compounds, including flavonoids, anthocyanins, phenolic acids, triterpene saponins, and alkaloid-like substances. Experimental studies confirm pronounced anti-inflammatory activity by inhibiting the synthesis of pro-inflammatory mediators such as prostaglandins and cytokines, by reducing the activity of cyclooxygenase and lipoxygenase enzymes. The antimicrobial effect is manifested by inhibiting the growth of Gram-positive and Gram-negative microorganisms, as well as fungi, which is associated with disruption of the integrity of pathogen cell membranes and inhibition of enzymes involved in their metabolism. The antiviral effect is associated with blocking the attachment of viral particles to cell receptors and disrupting the replication of the viral genome.

The antioxidant properties of the plant are determined by the high content of polyphenolic compounds capable of neutralizing free radicals and reducing oxidative stress, which helps protect cellular structures from damage. The immunomodulatory effect is manifested in the regulation of the activity of innate and adaptive immunity cells, including macrophages, T-lymphocytes, and natural killer cells, with a possible increase in phagocytic activity and antibody production.

On the skin, preparations from Impatiens balsamina have a local antiseptic, keratolytic, and wound healing effect, stimulating the processes of granulation and epithelialization. With transdermal and local use, a decrease in the intensity of inflammatory reactions, a reduction in exudation and itching sensations are observed. At the level of joints and connective tissues, active components can modulate the synthesis of inflammatory mediators and partially suppress catabolic enzymes involved in cartilage degradation.

A spasmolytic effect on smooth muscles is noted, which may be associated with an effect on calcium channels and mediator systems regulating muscle tone. The diuretic effect, detected in experimental models, is presumably realized through increased glomerular filtration and suppression of tubular sodium reabsorption. The local vasodilatory effect of plant components may be due to increased synthesis of nitric oxide in endothelial cells.

Thus, the pharmacodynamic profile of Impatiens balsamina is characterized by a multi-level effect on inflammatory, microbiological, oxidative, and regulatory processes in tissues, which is confirmed by data from pharmacological studies.

References: https://biointerfaceresearch.c...   https://www.sciencedirect.com/science/article/pii/S0378874122009953

Pharmacokinetics — Impatiens balsamina

Data on the pharmacokinetics of Impatiens balsamina in humans are limited, so its description is based on the study of similar groups of compounds that make up the plant. Following oral administration of aqueous and alcohol extracts, absorption of active substances occurs mainly in the small intestine with the participation of passive diffusion and, partially, transporter systems. Polar components, including flavonoids and phenolic acids, undergo partial hydrolysis by the intestinal microflora with the formation of aglycones that have higher lipophilicity and are able to rapidly penetrate into the systemic circulation.

With transdermal and local use, permeability through the stratum corneum of the skin depends on the lipophilicity of the form used: oil bases and creams facilitate better penetration of triterpenes and lipophilic pigments, while hydrophilic extracts remain predominantly on the skin surface, exerting a local effect. Through the mucous membranes of the oral cavity and nose, absorption occurs quickly, bypassing first-pass metabolism in the liver.

In the systemic circulation, active substances bind to plasma proteins, which ensures their transport and gradual release into tissues. Distribution is observed mainly in the skin, mucous membranes, liver, and kidneys. Some lipophilic fractions may temporarily accumulate in adipose tissue, providing prolonged release.

Metabolism occurs mainly in the liver with the participation of conjugation enzymes (glucuronidation, sulfation), as well as oxidases and reductases. A number of components undergo biotransformation with the formation of active metabolites that maintain pharmacological activity. Excretion of metabolites and unchanged compounds occurs in urine, bile, and, to a lesser extent, through the skin and lungs.

With long-term use, moderate accumulation of lipophilic fractions is possible, but research data indicate their gradual complete elimination within a few days after cessation of intake or use. Pharmacokinetic features depend on the dosage form used, the concentration of active substances, and the route of administration.

References: https://biointerfaceresearch.c...   https://www.sciencedirect.com/science/article/pii/S0378874122009953

Mechanisms of Action and Scientific Rationale — Impatiens balsamina

The biological activity of Impatiens balsamina is due to the content of flavonoids (kaempferol, quercetin), anthocyanins, phenolic acids (chlorogenic, p-coumaric), triterpenes, saponins, and naphthoquinones (lawsone). Flavonoids and phenolic acids inhibit the activity of the enzymes cyclooxygenase (COX-1, COX-2) and lipoxygenase (LOX), which reduces the synthesis of pro-inflammatory prostaglandins and leukotrienes. Naphthoquinones exhibit antimicrobial activity by disrupting the integrity of pathogen cell membranes and blocking enzymes involved in nucleic acid synthesis. The antioxidant potential is ensured by the activation of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) and the direct binding of free radicals. The immunomodulatory effect is associated with the regulation of cytokine production (IL-1β, IL-6, TNF-α) and modulation of macrophage and neutrophil activity. Phenolic components can affect the NF-κB, MAPK, and JAK/STAT signaling pathways, regulating the expression of genes responsible for the inflammatory response. Locally, the active substances of the plant stimulate fibroblast proliferation and collagen synthesis, accelerating reparative processes in the skin and mucous membranes. A possible interaction with calcium channels and receptor systems involved in the regulation of smooth muscle tone has been noted, which may explain the spasmolytic effect.

References: https://www.sciencedirect.com/...   https://pubmed.ncbi.nlm.nih.go...

Synergy — Impatiens balsamina

In vitro and in vivo experimental studies indicate pronounced pharmacological synergy of Impatiens balsamina with a number of other plant taxa and natural compounds. Co-administration with Curcuma longa enhances the antioxidant and anti-inflammatory effect due to the additive inhibition of NF-κB and COX-2 pathways. In combination with Azadirachta indica, potentiation of antimicrobial activity is observed, which is associated with the combined destruction of bacterial cell membranes and suppression of pathogen enzyme systems. Extracts of Camellia sinensis in combination with Impatiens balsamina demonstrate increased cell protection against oxidative stress, due to the cumulative enhancement of antioxidant enzyme activity. Interaction with polyphenols of Vitis vinifera is manifested in the modulation of cytokine synthesis and a decrease in the production of reactive oxygen species at the cellular level. Saponins of Glycyrrhiza glabra in combination with components of Impatiens balsamina have a modulating effect on the immune response, including the stimulation of phagocytic activity of macrophages. The nature of the interaction in most cases is potentiating or additive, and the mechanism of action includes the combined inhibition of pro-inflammatory mediators, enhancement of antioxidant defense, and optimization of the metabolic activity of target cells.

References: https://pubmed.ncbi.nlm.nih.go...   https://www.sciencedirect.com/science/article/pii/S0378874122009953

Geography of use and traditional medicine — Impatiens balsamina

Impatiens balsamina has a wide ethnobotanical distribution in tropical and subtropical regions of Asia, including China, Thailand, Vietnam, India, Laos, Cambodia, Myanmar, as well as Korea and Japan. In traditional Chinese medicine, the plant is known as 鳳仙花 and was used mainly in the form of pastes from fresh flowers and leaves, decoctions, and alcohol tinctures. In Thai folk medicine, it is used in the form of compresses and infusions for external use, as well as an ingredient in herbal baths. In the Indian Ayurvedic tradition, Impatiens balsamina is part of oils and pastes for skin care, as well as in massage formulations. Among the Vietnamese, the plant was used in the form of flower juice for nail coloring, which had both aesthetic and symbolic significance associated with rituals and holidays.

Historical mentions of the use of the plant date back to at least the 14th–15th centuries, when it was recorded in Chinese and Korean botanical treatises as a means for household and ritual purposes. In Japan, Impatiens balsamina is known as tsubaki-hana and is associated with summer gardens, and in some regions — with protective functions, when branches or flowers were hung at the entrance of the house to protect against evil spirits.

In a number of Southeast Asian cultures, the plant was considered a "plant of power" capable of cleansing space and a person of "bad energy." It was used in purification rituals, as well as in the composition of protective amulets. Flower juice was sometimes used in ritual coloring of skin and nails, which symbolized vitality and protected against the evil eye. In some ethnic groups of Laos and Cambodia, crushed parts of the plant were smoked in a mixture with other herbs in ceremonies aimed at expelling disease-causing spirits.

Thus, the geography of use of Impatiens balsamina covers a significant part of Asia, where it has both medical and cultural significance, and the forms of its traditional use range from therapeutic compresses to ritual and aesthetic practices.