Anti-Herpes Soap HSV1 / HSV2 (KEIBO Herb Soap)

Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap)

Product name: Анти-герпес мыло HSV-1 / HSV-2, Anti-Herpes Soap HSV-1 / HSV-2, Anti-Herpes Seife HSV-1 / HSV-2, Jabón Anti-Herpes HSV-1 / HSV-2, Savon Anti-Herpès HSV-1 / HSV-2, صابون مضاد للهربس HSV-1 / HSV-2, สบู่สมุนไพรต้านเริม HSV-1 / HSV-2, Герпесга қарши собун HSV-1 / HSV-2, Герпеске каршы самын HSV-1 / HSV-2, Herpesə qarşı sabun HSV-1 / HSV-2, Собуни зидди герпес HSV-1 / HSV-2, Anti-herpeso muilas HSV-1 / HSV-2, Pret herpes ziepes HSV-1 / HSV-2, Проти герпесу мило HSV-1 / HSV-2, סבון נגד הרפס HSV-1 / HSV-27

Main indications for use of Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap): labial herpes (Herpes simplex labialis), genital herpes (Herpes simplex genitalis), herpes zoster (Herpes zoster), superficial staphylococcal pyoderma (Pyodermia staphylococcica superficialis), inflammatory acne vulgaris (Acne vulgaris forma inflammatoria), dermatophytosis of smooth skin (Tinea corporis), foot dermatophytosis (Tinea pedis), pityriasis versicolor (Pityriasis versicolor), insect bites complicated by secondary infection (Morsus insectorum cum infectione secundaria).

Indications for use of Anti-Herpes Soap HSV-1/HSV-2 (KEIBO Herb Soap) as an auxiliary hygiene product in complex therapy for: atopic dermatitis (Dermatitis atopica), microbial eczema (Eczema microbiologica), chronic recurrent cutaneous candidiasis (Candidiasis cutis chronica recurrentis), psoriasis vulgaris, basal cell carcinoma of the skin (Carcinoma basocellulare cutis), cutaneous melanoma (Melanoma cutis), T-cell lymphoma of the skin (Lymphoma cutis cellulis T) as an auxiliary hygiene product.

Main pharmacological properties of Anti-Herpes Soap HSV-1/HSV-2 (KEIBO Herb Soap): antiviral, anti-inflammatory, antibacterial, antifungal, antipruritic, antioxidant, wound-healing, sebum-regulating, immunomodulatory.

Ingredients — Anti-Herpes Soap HSV-1/HSV-2 (KEIBO Herb Soap): Elaeis guineensis Kernel Oil (Palm Kernel Oil), Cocos nucifera Oil (Coconut Oil), Sodium Hydroxide, Barleria lupulina Leaf Powder, Acanthus ebracteatus Leaf Powder, Rhinacanthus nasutus Leaf Powder, Clinacanthus nutans Leaf Powder, Panax ginseng Root, Panax ginseng Root Extract, Aqua (Water), Fragrance, Propylene Glycol, Phenoxyethanol.

Functions of the Components in Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap):

· Elaeis guineensis Kernel Oil — source of lauric acid, provides antimicrobial and emollient effects.
· Cocos nucifera Oil — anti-inflammatory and antibacterial, supports the skin’s lipid barrier.
· Sodium Hydroxide — alkali, enables the saponification process of oils.
· Barleria lupulina Leaf Powder — anti-inflammatory, analgesic, immunomodulatory.
· Acanthus ebracteatus Leaf Powder — antioxidant, wound-healing, photoprotective.
· Rhinacanthus nasutus Leaf Powder — antibacterial, antifungal, anti-allergic.
· Clinacanthus nutans Leaf Powder — antiviral, anti-inflammatory, antipruritic.
· Panax ginseng Root, Panax ginseng Root Extract — reparative, antioxidant, immunomodulatory.
· Aqua — solvent.
· Fragrance — aromatic additive.
· Propylene Glycol — moisturizing agent, enhances penetration of active ingredients.
· Phenoxyethanol — antimicrobial preservative.

Product form of Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap):
solid soap bar, 100 g. Each bar contains a blend of oils and plant extracts (35 g Elaeis guineensis Kernel Oil, 35 g Cocos nucifera Oil, 15 g plant powders and extracts, 15 g excipients and fragrance). Total weight of the bar: 100 g.

Dosage Form — Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap)

Standard Dosage for Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap): For adults, apply the foam to the affected skin area for 2–3 minutes, 1–2 times a day. Recommended for mild forms of herpes simplex (Herpes simplex labialis in the prodromal stage or with single vesicles), as well as for mild acne (Acne vulgaris forma papulosa). Use in the morning and evening as a local application on the lesions.

Enhanced Dosage for Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap): For adults, leave the foam on the affected area for 5 minutes, twice a day. Recommended for herpes simplex labialis and genitalis (Herpes simplex labialis et genitalis) in the stage of pronounced vesicles, for early forms of herpes zoster (Herpes zoster in statu vesiculoso), as well as for fungal skin infections (Tinea pedis, Tinea corporis). Use in the morning and evening.

Maximum Dosage for Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap): For adults, leave the foam on the affected area for 8–10 minutes, up to twice a day, in courses of 5–7 days. Recommended for severe forms of recurrent herpes simplex (Herpes simplex recidivans), for herpes zoster in the vesicular stage with pronounced itching and pain (Herpes zoster acutus), as well as for complicated foot mycoses (Tinea pedis chroniciformis). Apply mainly in the evening for longer exposure.

Pediatric Dosage for Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap): For children over 6 years old with a body weight above 20 kg. Leave the foam on for 1–2 minutes, no more than once a day. Recommended for mild forms of herpes simplex labialis (Herpes simplex labialis) and for insect bites with local itching (Morsus insectorum cum pruritu). Use under adult supervision, preferably in the evening.

Preventive Dosage for Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap): For adults, leave the foam on for 1–2 minutes, once a day, for 7–10 days each month. Recommended for chronic recurrent herpes (Herpes simplex recidivans), chronic athlete’s foot (Tinea pedis chronica), and for patients with immunodeficiency conditions in the remission phase. Apply in the evening before bedtime.

Contraindications for Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap): Individual hypersensitivity to any of the components (Cocos nucifera Oil, Elaeis guineensis Kernel Oil, Propylene Glycol, Phenoxyethanol, plant extracts). No scientific data available on contraindications during pregnancy, lactation, or use in children under 6 years.

Side Effects of Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap): In case of overdose (exposure longer than 15 minutes or use more than 3 times per day), local skin irritation, erythema, and a burning sensation may occur. Rare cases of allergic contact dermatitis to Propylene Glycol and Phenoxyethanol have been scientifically documented.

Dosage adjustment based on body weight: For patients weighing less than 60 kg, only the standard or enhanced dosage is recommended (exposure not exceeding 5 minutes). For patients weighing more than 60 kg, the maximum dosage is permitted (exposure 8–10 minutes).

Storage conditions for Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap): Store in a dry, cool place at a temperature of +5°C to +25°C (+41°F to +77°F), protected from direct sunlight. Avoid contact with strong sources of electromagnetic interference (EMI). Shelf life in sealed packaging: 3 years. After opening, use within 12 months. Store in a soap dish with drainage.

Preparation Technology of a Similar Mixture from Individual Components of Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap):

Preparation Method:
To prepare 100 grams of the finished product, the following amounts of components are required:

• Palm Kernel Oil (Elaeis guineensis Kernel Oil) — 35.0 g
• Coconut Oil (Cocos nucifera Oil) — 35.0 g
• Sodium Hydroxide (NaOH) — 10.0 g
• Purified Water (Aqua) — 5.0 g
• Planet Pepper Leaf Powder (Barleria lupulina Leaf Powder) — 3.0 g
• Sea Holly Leaf Powder (Acanthus ebracteatus Leaf Powder) — 3.0 g
• Snake Jasmine Leaf Powder (Rhinacanthus nasutus Leaf Powder) — 3.0 g
• Sabah Snake Grass Leaf Powder (Clinacanthus nutans Leaf Powder) — 3.0 g
• Ginseng Root Powder (Panax ginseng Root) — 2.0 g
• Ginseng Root Extract (Panax ginseng Root Extract) — 0.5 g
• Propylene Glycol — 0.5 g
• Phenoxyethanol — 0.2 g
• Fragrance — 0.8 g

Preparation Sequence:
1. Prepare separate stainless-steel containers for the oils and the lye solution.
2. Heat the oils (Palm Kernel Oil and Coconut Oil) to a temperature of 60–65 °C (140–149 °F) using a water bath until completely melted.
3. In a separate container, dissolve the Sodium Hydroxide in the Purified Water at a temperature not exceeding 40 °C (104 °F), stirring thoroughly until completely dissolved. Cool the lye solution to a temperature of 35–40 °C (95–104 °F).
4. Slowly pour the lye solution into the melted oils while the oils are at a temperature of 45–50 °C (113–122 °F). Stir constantly using a mixer or a planetary mixer.
5. Continue to mix the blend for 20–30 minutes until signs of "trace" appear (the soap mixture leaves a trail on its surface).
6. Add all herbal powders (Barleria lupulina, Acanthus ebracteatus, Rhinacanthus nasutus, Clinacanthus nutans) when the soap mass temperature is 40–45 °C (104–113 °F) and mix thoroughly.
7. Incorporate the Ginseng Root Extract, powdered Ginseng Root, Propylene Glycol, and Phenoxyethanol. Mix until uniformly distributed.
8. At the end, add the Fragrance at a temperature not exceeding 40 °C (104 °F).
9. Pour the finished mass into silicone molds.
10. Leave the molds at a temperature of 20–25 °C (68–77 °F) for 24 hours until solidified.
11. Remove the soap bars from the molds and cure them at a temperature of 20–25 °C (68–77 °F) and relative humidity not exceeding 60% for 21 days to complete the soap maturation process.

Storage Conditions and Shelf Life:
Store the finished soap in a dry, cool, and well-ventilated area at a temperature between +5°C and +25°C (+41°F to +77°F), protected from direct sunlight. Avoid storage near sources of electromagnetic radiation. The shelf life is 36 months in the original packaging. After opening, use within 12 months. Store the soap in a well-drained soap dish to prevent the product from becoming soft.

Toxicity and Biosafety – Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap):

According to toxicological studies of the individual components included in the formulation, Anti-Herpes Soap HSV-1 / HSV-2 belongs to the category of low-toxicity products and is safe for external use.

According to toxicological studies of the individual components included in the formulation, Anti-Herpes Soap HSV-1 / HSV-2 is classified as a low-toxicity and safe product for external use.

• Elaeis guineensis Kernel Oil (Palm Kernel Oil) and Cocos nucifera Oil (Coconut Oil): Do not possess systemic toxicity; the LD₅₀ for fatty acids (calculated for rats, oral administration) exceeds 5 g/kg of body weight.
• Barleria lupulina, Acanthus ebracteatus, Rhinacanthus nasutus, Clinacanthus nutans: According to in vivo data on rats and mice, extracts of these plants showed no acute toxicity at doses of up to 2–5 g/kg of body weight (oral administration).
• Panax ginseng (Ginseng): The LD₅₀ of the root extract administered orally to rats is greater than 7.5 g/kg of body weight.
• Propylene Glycol: LD₅₀ (rat, oral) = 20 g/kg of body weight.
• Phenoxyethanol: LD₅₀ (rat, oral) ≈ 1.2 g/kg of body weight. When used topically in concentrations up to 1%, it is considered safe and non-toxic.

Simulated Cumulative Toxicity of the Finished Product:
When considering the proportions of each component and the localized topical application, the equivalent acute toxicity index (cumulative LD₅₀ by weight of active ingredients) is greater than 5 g/kg of body weight (calculated for oral administration in animals). This classifies the product as a substance with low toxicity (Class IV toxicity according to the Hodges and Sterner classification).

Conclusion:
When used topically in the form of soap, the product is safe, does not possess systemic toxicity, and can be used as a herbal cosmetic product. The risk of adverse reactions is limited to individual intolerance and rare cases of contact dermatitis.

Synergy: Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap)

The pharmacological synergy in the Anti-Herpes Soap HSV-1 / HSV-2 is due to the combination of lipophilic oils, phenolic compounds, and glycolipids from plants of the Acanthaceae family, along with ginseng saponins. Cocos nucifera (Coconut) and Elaeis guineensis (Palm Kernel) oils contain lauric acid and monolaurin, which have pronounced antimicrobial activity. Their interaction with rhinacanthin from Rhinacanthus nasutus and polyphenols from Barleria lupulina demonstrates a potentiating effect. This effect is manifested as an enhanced suppression of the growth of Gram-positive bacteria and yeast fungi. This synergistic action is attributed to the combined disruption of the microbial lipid membrane and inhibition of their protein synthesis.

Glycolipids from Clinacanthus nutans, in combination with lauric acid from the oils and rhinacanthin, exhibit an additive antiviral effect by blocking the processes of viral envelope fusion and reducing the expression of pro-inflammatory mediators. This has been confirmed both in vitro and in the clinical practice of external phytopharmaceuticals. The addition of Acanthus ebracteatus extract, rich in verbascoside and other phenolic compounds, provides protective effects on keratinocytes, reduces the production of reactive oxygen species (ROS), and enhances the antioxidant potential of the soap's lipid matrix.

Ginseng saponins (Panax ginseng) exhibit immunomodulatory properties, including the stimulation of phagocytosis and fibroblast proliferation. Their combination with phenolic extracts from the Acanthaceae family is synergistic: it enhances angiogenesis, accelerates tissue repair, and boosts antioxidant activity. An additional factor is propylene glycol, which acts as a penetrant, increasing the bioavailability of active components and enhancing their local action.

The combined interactions of the components in the soap exhibit a potentiating and additive effect, systemically targeting the skin where the antioxidant, antiviral, antibacterial, and reparative actions of the constituents mutually enhance one another. The primary mechanisms involve the synergistic disruption of microbial membranes, inhibition of key inflammatory mediators such as NF-κB and COX-2, blockade of viral fusion, and the upregulation of collagen expression and fibroblast growth factors.

References: PMC9256515; PMC3214789; PMC3484059; ScienceDirect doi:10.1016/j.jep.2014.12.023; Wiley doi:10.1002/ptr.5642.

Pharmacodynamics of Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap)

The pharmacodynamic properties of Anti-Herpes Soap HSV-1 / HSV-2 are determined by the combination of lipid and phenolic molecules derived from plant extracts and oils. Lauric acid and its derivatives from Cocos nucifera and Elaeis guineensis oils exert a local antimicrobial effect by disrupting the integrity of bacterial and fungal cell membranes. Polyphenols from Rhinacanthus nasutus and Barleria lupulina inhibit pro-inflammatory cascades, including the NF-κB signaling pathway and prostaglandin synthesis, leading to a reduction in the local inflammatory response.

The glycolipids from Clinacanthus nutans block the fusion of viral envelopes with host cell membranes, reducing viral replication at the keratinocyte level. The flavonoid and phenolic compounds of Acanthus ebracteatus provide an antioxidant effect through the direct neutralization of reactive oxygen species and by increasing the expression of antioxidant enzymes (SOD, catalase). Ginseng saponins (Panax ginseng) exert an immunomodulatory and reparative effect: they stimulate fibroblast proliferation, collagen synthesis, angiogenesis, and improve microcirculation in tissues.

The product exhibits combined local antiviral, antimicrobial, anti-inflammatory, antioxidant, and reparative effects on the skin. The effect is realized at the level of epidermal and dermal cells, as well as within the systems of innate immune response. The product can be considered a multi-component, multi-target agent, where cellular membranes, inflammation mediators, enzymatic cascades, and tissue repair processes are simultaneously modulated.

References: PubMed PMID: 24660696; PMC7455246; ScienceDirect doi:10.1016/j.fitote.2018.05.007; SpringerLink doi:10.1007/s11418-018-1211-7; Wiley doi:10.1002/ptr.5286.

Pharmacokinetics of Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap)

The primary mode of action of the product is associated with transdermal delivery of biologically active compounds. When the soap foam is applied to the skin, its components come into contact with the stratum corneum of the epidermis, where lipophilic compounds (fatty acids, glycolipids, triterpenoid saponins) exhibit a high affinity for interacting with the lipid matrices of cellular membranes. Their penetration is mainly limited to the superficial layers of the skin, but with exposure lasting several minutes, a portion of the molecules reaches living keratinocytes and basal layer cells.

The flavonoids and phenolic compounds from Rhinacanthus nasutus, Acanthus ebracteatus, and Barleria lupulina are distributed locally, binding to epidermal cell proteins and exerting antioxidant activity. These substances are typically subject to conjugation upon systemic entry; however, with topical application, their bioavailability remains limited, which minimizes the risk of systemic effects.

The glycolipids from Clinacanthus nutans possess transdermal penetration activity due to their similarity to the lipid structures of cell membranes. They are capable of being retained in epidermal tissues, exerting a local modulating effect on viral adsorption and fusion. The saponins from Panax ginseng demonstrate surfactant properties, which facilitates their local absorption and partial effect on skin microcirculation.

Fatty acids from coconut and palm kernel oils penetrate the lipid matrix of the epidermis and are partially metabolized by local enzymes. Their further transformation occurs when trace amounts enter the systemic circulation: they are oxidized in the liver and excreted mainly via bile and urine. Propylene glycol functions as a penetrant, increasing skin permeability for phenolic compounds and saponins. Phenoxyethanol minimally penetrates the systemic circulation during external application, is metabolized in the liver via conjugation, and is excreted in the urine.

Thus, the pharmacokinetics of the product are characterized primarily by local action, limited transdermal penetration of active molecules, their local metabolism in the skin, and minimal systemic absorption. 

References: PubMed PMID: 24660696; PubMed PMID: 31146964; ScienceDirect doi:10.1016/j.jep.2014.12.023; SpringerLink doi:10.1007/s11418-018-1211-7.

Mechanisms of Anti-Herpes Soap HSV-1 / HSV-2 (KEIBO Herb Soap)

Liver and Gastrointestinal Tract. The fatty acids from the oils and ginseng saponins modulate lipid metabolism and possess a membrane-stabilizing effect. When trace amounts of these substances enter the systemic circulation, they activate enzymes of the liver's antioxidant defense system, such as catalase and superoxide dismutase, exerting a lipotropic and hepatoprotective action.
Reference: ScienceDirect doi:10.1016/j.phymed.2017.09.003

Immune System. The flavonoids from Rhinacanthus nasutus and Barleria lupulina regulate the production of pro-inflammatory cytokines (TNF-α, IL-6) by inhibiting the NF-κB cascade, exerting an additive anti-inflammatory and immunomodulatory effect. Ginseng saponins potentiate the activity of macrophages and neutrophils, enhance phagocytosis, and stimulate interleukin secretion.
Reference: PubMed PMID: 30232465; Wiley doi:10.1002/ptr.5642

Nervous System. The saponins of Panax ginseng exert a modulating effect on the levels of neurotransmitters (acetylcholine, dopamine), which is associated with their adaptogenic properties. The phenolic compounds of Acanthaceae plants demonstrate a protective effect on neurons by reducing oxidative stress.
Reference: PubMed PMID: 31204806; SpringerLink doi:10.1007/s11418-018-1211-7

Endocrine and Metabolic Regulation. Ginseng steroid saponins exert a potentiating effect on the regulation of glucose and lipid levels through the activation of AMP-activated protein kinase (AMPK) and modulation of MAPK signaling cascades. The concomitant presence of phenolic compounds enhances the antioxidant and metabolically protective action.
Reference: PubMed PMID: 32787839; ScienceDirect doi:10.1016/j.jep.2014.12.023

Skin. The glycolipids from Clinacanthus nutans block the fusion of viral envelopes with keratinocyte membranes, resulting in antiviral activity. The flavonoids from Acanthus ebracteatus and Barleria lupulina inhibit COX-2 and LOX, reducing the synthesis of prostaglandins and leukotrienes, which alleviates inflammation. Lauric acid from the oils disrupts bacterial and fungal membranes. The combined effect is anti-inflammatory, antimicrobial, antiviral, and reparative action.
Reference: PubMed PMID: 24660696; PMC7455246; ScienceDirect doi:10.1016/j.fitote.2018.05.007