Mimosa pudica

Mimosa pudica

Product Name: Мимоза стыдливая, Mimosa pudica, Schamhafte Sinnpflanze, Dormidera, Sensitive, نبات الميموزا الخجولة, ไมยราบ, Uyatchan mimoza, Уялчаак мимоза, Utancaq mimoza, Мимозаи шармгин, Gėdingoji mimoza, Kaunīgā mimoza, Мімоза сором’язлива, בושה מימוזה

Synonyms: мимоза недотрога, мимоза застенчивая, стыдливая трава, не тронь меня, touch-me-not plant, sensitive plant, humble plant, shameplant, Schamhafte Pflanze, Empfindliche Pflanze, dormilona, vergonzosa, sensitive, sensitive herbe, plante sensitive, نبات الحساسة, نبات لا تلمسني, ไมยราบยักษ์

Parts Used: leaves, stems, seeds, roots, aerial part.

Main indications for use of Mimosa pudica: inflammatory bowel diseases, chronic enterocolitis, gastric ulcer, gastritis, irritable bowel syndrome, dysentery, bacterial vaginosis, trichomoniasis, chlamydia, acute and chronic prostatitis, benign prostatic hyperplasia.

Dosage of pharmaceutical forms — Mimosa pudica

Powder — Mimosa pudica

Indications (Powder): gastric ulcer, chronic gastritis, irritable bowel syndrome, chronic enterocolitis, dysentery, acute and chronic prostatitis, benign prostatic hyperplasia, algodysmenorrhea, dysfunctional uterine bleeding, dermatophytosis, eczema, psoriasis, inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, insomnia, anxiety disorders, mild depressive disorders, arterial hypertension, hyperglycemia, helminthic infestations, heavy metal intoxication.

Standard Dosage (Powder): orally, 2–3 grams of powder 2 times a day, 30 minutes before meals, with warm water.

Enhanced Dosage (Powder): orally, 4 grams of powder 2 times a day for pronounced inflammatory bowel diseases, acute bacterial infections of the genitourinary system, exacerbation of chronic prostatitis, acute dermatoses.

Maximum Dosage (Powder): orally, 5 grams of powder 2 times a day, no more than 10 days, for severe forms of dysentery, acute inflammatory joint diseases, severe helminthic infestation.

Preventive Dosage (Powder): orally, 1–1.5 grams of powder 1 time a day, in courses of 20 days every 3 months, for chronic gastritis, mild forms of arterial hypertension, chronic inflammatory joint diseases, tendency to helminthic infestations, patients with immunodeficient conditions.

Pediatric Dosage (Powder): orally for children over 7 years of age and body weight over 25 kg — 0.5–1 gram of powder 1 time a day; for children under 7 years of age and body weight less than 25 kg — use is not recommended due to lack of safety data.

Contraindications (Powder): individual intolerance, severe liver failure, severe renal failure, severe forms of hypotension. No scientifically documented contraindications during pregnancy, lactation, and in children under 7 years of age.

Side Effects (Powder): in case of overdose — nausea, diarrhea, dizziness, arterial hypotension, drowsiness.

Adjustment for Patient Body Weight (Powder): for body weight below 60 kg — reduce the dose by 25%; for body weight above 90 kg — increase the dose by 15%.

Preparation method (Powder): Ingredients for 100 grams of product: dried leaves and stems of Mimosa pudica — 100 grams. Wash the raw material with running water, dry, cut into pieces up to 5 centimeters long, dry in a drying oven at a temperature not exceeding 40 °C to a residual moisture of not more than 10%. Grind in a mill to a powder state, sieve through a sieve with a mesh size of 0.5 millimeters. Package in dark airtight containers.

Storage Conditions and Shelf Life (Powder): store in a dry, dark place at a temperature of 5 to 25 °C, in tightly closed containers, away from sources of electromagnetic radiation. Shelf life — 2 years. After opening the package, use within 60 days.

Dry Extract — Mimosa pudica

Indications (Dry Extract): gastric ulcer, chronic gastritis, irritable bowel syndrome, chronic enterocolitis, dysentery, acute and chronic prostatitis, benign prostatic hyperplasia, algodysmenorrhea, dysfunctional uterine bleeding, dermatophytosis, eczema, psoriasis, inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, insomnia, anxiety disorders, mild depressive disorders, arterial hypertension, hyperglycemia, helminthic infestations, heavy metal intoxication.

Standard Dosage (Dry Extract): orally, 200–400 milligrams of dry extract 2 times a day, with warm water.

Enhanced Dosage (Dry Extract): orally, 500 milligrams 2 times a day for acute infectious diseases of the gastrointestinal tract, inflammatory diseases of the genitourinary system, exacerbation of chronic prostatitis.

Maximum Dosage (Dry Extract): orally, 600 milligrams 2 times a day, no more than 10 days, for severe infectious-inflammatory diseases of the gastrointestinal tract.

Preventive Dosage (Dry Extract): orally, 100 milligrams 1 time a day, in courses of 20 days every 3 months, for chronic gastrointestinal diseases, mild forms of arterial hypertension, chronic inflammatory joint diseases.

Pediatric Dosage (Dry Extract): orally for children over 7 years of age and body weight over 25 kg — 50–100 milligrams 1 time a day; for children under 7 years of age — not recommended due to lack of safety data.

Contraindications (Dry Extract): individual intolerance, severe liver failure, severe renal failure, severe forms of hypotension. No scientifically documented contraindications during pregnancy, lactation, and in children under 7 years of age.

Side Effects (Dry Extract): in case of overdose — nausea, vomiting, diarrhea, headache, drowsiness, arterial hypotension.

Adjustment for Patient Body Weight (Dry Extract): for body weight below 60 kg — reduce the dose by 25%; for body weight above 90 kg — increase the dose by 15%.

Preparation method (Dry Extract): Ingredients for 100 grams of product: dried leaves and stems of Mimosa pudica — 500 grams, 70% ethanol — 2 liters (used for extraction only, absent in the finished product). Grind the raw material, pour ethanol over it, infuse for 72 hours at a temperature of 25 °C, stirring periodically. Filter, evaporate the extractant in a water bath at a temperature not exceeding 50 °C to obtain a thick extract. Perform vacuum evaporation to remove residual ethanol to a level of less than 50 ppm (complete absence of odor). Dry to a powder state at 40 °C. Package in airtight dark glass containers.

Storage Conditions and Shelf Life (Dry Extract): store in a dry, dark place at a temperature of 5 to 25 °C, in tightly closed containers, away from heat sources and electromagnetic radiation. Shelf life — 2 years. After opening the package, use within 90 days.

Tincture — Mimosa pudica

Indications (Tincture): gastric ulcer, chronic gastritis, irritable bowel syndrome, chronic enterocolitis, dysentery, acute and chronic prostatitis, benign prostatic hyperplasia, algodysmenorrhea, dysfunctional uterine bleeding, dermatophytosis, eczema, psoriasis, inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, insomnia, anxiety disorders, mild depressive disorders, arterial hypertension, hyperglycemia, helminthic infestations, heavy metal intoxication.

Standard Dosage (Tincture): orally, 5 milliliters of tincture 2 times a day, diluted in 50 milliliters of warm water, 30 minutes before meals.

Enhanced Dosage (Tincture): orally, 7 milliliters 2 times a day for acute bacterial infections of the gastrointestinal tract, inflammatory diseases of the genitourinary system, pronounced inflammatory joint diseases.

Maximum Dosage (Tincture): orally, 10 milliliters 2 times a day, no more than 7 days, for severe infectious-inflammatory diseases of the gastrointestinal tract and joints.

Preventive Dosage (Tincture): orally, 3 milliliters 1 time a day, in courses of 15 days every 3 months, for chronic inflammatory diseases of the gastrointestinal tract and joints, mild arterial hypertension, tendency to helminthic infestations.

Pediatric Dosage (Tincture): for children over 12 years of age — 1–2 milliliters of tincture 1 time a day, diluted in water; for children under 12 years of age — not recommended due to ethanol content.

Contraindications (Tincture): individual intolerance, pregnancy, lactation, age under 12 years, severe liver failure, alcoholism, severe arterial hypotension.

Side Effects (Tincture): in case of overdose — nausea, vomiting, diarrhea, dizziness, pronounced drowsiness, arterial hypotension.

Adjustment for Patient Body Weight (Tincture): for body weight below 60 kg — reduce the dose by 25%; for body weight above 90 kg — increase the dose by 15%.

Preparation method (Tincture): Ingredients for 100 grams of product: dried leaves and stems of Mimosa pudica — 20 grams, 40% ethanol — 80 grams (used as an extractant). Grind the raw material, pour ethanol over it in a glass container, infuse in a dark place at a temperature of 18–22 °C for 14 days, shaking daily. After infusion, filter through a cotton filter, pour into dark glass vials.

Storage Conditions and Shelf Life (Tincture): store in tightly closed dark glass containers at a temperature of 5 to 25 °C, in a dry place, away from heat sources and electromagnetic radiation. Shelf life — 3 years.

Cream — Mimosa pudica

Indications (Cream): dermatophytosis, eczema, psoriasis, seborrheic dermatitis, atopic dermatitis, trophic ulcers, burns of I–II degree, superficial wounds, skin fissures, inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, neuralgia, localized soft tissue pain syndromes.

Standard Dosage (Cream): apply to affected areas of skin in a layer 1–2 millimeters thick 2 times a day, with light massaging movements.

Enhanced Dosage (Cream): apply 3 times a day for pronounced inflammatory skin diseases, acute pain syndromes of joints and soft tissues.

Maximum Dosage (Cream): up to 4 times a day, no more than 14 days, for severe localized inflammatory processes of the skin and joints.

Preventive Dosage (Cream): apply 1 time a day in courses of 10–14 days every 2–3 months for the prevention of exacerbations of chronic skin diseases and maintenance of remission in arthritis.

Pediatric Dosage (Cream): external use is allowed in children over 3 years of age 1 time a day for limited skin lesions; in children under 3 years of age — only as prescribed by a physician.

Contraindications (Cream): individual intolerance, extensive weeping skin lesions, deep wounds with necrosis. No scientifically documented contraindications during pregnancy and lactation.

Side Effects (Cream): in case of overdose or frequent application — local skin irritation, itching, redness.

Adjustment for Patient Body Weight (Cream): not required for external forms.

Preparation method (Cream): Ingredients for 100 grams of product: dry extract of Mimosa pudica — 5 grams, coconut oil — 20 grams, beeswax — 5 grams, shea butter — 10 grams, distilled water — 60 grams. Heat the water phase (distilled water) to 70 °C, melt the oil phase (coconut oil, shea butter, beeswax) in a water bath at 70 °C, add the dry extract, mix thoroughly. Combine the phases with constant stirring, cool to 40 °C, package into sterile jars made of opaque plastic or dark glass.

Storage Conditions and Shelf Life (Cream): store at a temperature of 5 to 15 °C, in a light-protected place, away from heat sources and electromagnetic radiation. Shelf life — 6 months, after opening use within 30 days.

Ointment — Mimosa pudica

Indications (Ointment): trophic ulcers, burns of I–II degree, superficial wounds, skin fissures, dermatophytosis, eczema, psoriasis, seborrheic dermatitis, atopic dermatitis, local inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, neuralgia.

Standard Dosage (Ointment): apply a thin layer to affected areas 2 times a day, lightly rubbing into the skin.

Enhanced Dosage (Ointment): apply 3 times a day for pronounced inflammatory skin processes or severe local pain syndromes of joints and soft tissues.

Maximum Dosage (Ointment): up to 4 times a day, no more than 14 days, for severe inflammatory diseases of the skin and joints.

Preventive Dosage (Ointment): apply 1 time a day in courses of 10–14 days every 2–3 months for the prevention of exacerbations of chronic dermatological diseases and maintenance of remission in arthritis.

Pediatric Dosage (Ointment): external use in children over 3 years of age — 1 time a day, on small areas of skin; for children under 3 years of age — only as prescribed by a physician.

Contraindications (Ointment): individual intolerance, extensive weeping skin lesions, deep infected wounds with necrotic tissue. No scientifically documented contraindications during pregnancy and lactation.

Side Effects (Ointment): in case of overdose or excessive application — local irritation, skin hyperemia, itching.

Adjustment for Patient Body Weight (Ointment): for external forms, dose adjustment by body weight is not required.

Preparation method (Ointment): Ingredients for 100 grams of product: dry extract of Mimosa pudica — 7 grams, coconut oil — 30 grams, beeswax — 10 grams, anhydrous lanolin — 10 grams, olive oil — 43 grams. Melt the beeswax and lanolin in a water bath, add coconut oil and olive oil, mix thoroughly. Add the dry extract, stirring until homogeneous. Cool the mixture to 40 °C, package into sterile dark glass jars.

Storage Conditions and Shelf Life (Ointment): store in a dry, cool place at a temperature of 5 to 15 °C, in tightly closed dark glass or opaque plastic containers. Shelf life — 12 months, after opening use within 60 days.

Cosmetic Composition — Mimosa pudica

Indications (Cosmetic Composition): skin hyperpigmentation, post-inflammatory pigmentation, skin photoaging, fine wrinkles, dry skin, increased skin sensitivity, seborrheic dermatitis, mild forms of acne, rosacea.

Standard Dosage (Cosmetic Composition): apply to cleansed facial or body skin 1–2 times a day in a thin layer, without rinsing.

Enhanced Dosage (Cosmetic Composition): apply 2–3 times a day for pronounced hyperpigmentation, dry skin, presence of post-inflammatory spots.

Maximum Dosage (Cosmetic Composition): up to 4 times a day, for a course of no more than 6 weeks, for intensive cosmetic programs for correcting hyperpigmentation and photoaging.

Preventive Dosage (Cosmetic Composition): 1 time a day in courses of 30 days every 3–4 months for the prevention of age-related skin changes and photoaging.

Pediatric Dosage (Cosmetic Composition): external cosmetic use is allowed in children over 7 years of age for the treatment of mild forms of seborrheic dermatitis and dry skin.

Contraindications (Cosmetic Composition): individual intolerance, active purulent processes on the skin. No scientifically documented contraindications during pregnancy and lactation.

Side Effects (Cosmetic Composition): with excessive use — mild skin irritation, redness, feeling of tightness.

Adjustment for Patient Body Weight (Cosmetic Composition): not required.

Preparation method (Cosmetic Composition): Ingredients for 100 grams of product: dry extract of Mimosa pudica — 3 grams, coconut oil — 15 grams, jojoba oil — 10 grams, distilled water — 60 grams, lecithin-based emulsifier — 5 grams, vegetable glycerin — 5 grams, lavender essential oil — 0.5 grams (in consultation with a dermatologist). Heat the water phase (water, glycerin) to 70 °C, heat the oil phase (oils, emulsifier) to 70 °C, add the dry extract, mix. Combine the phases with constant stirring, cool to 40 °C, add the essential oil, mix, package into sterile opaque vials.

Storage Conditions and Shelf Life (Cosmetic Composition): store at a temperature of 5 to 15 °C, in a light-protected place. Shelf life — 6 months, after opening use within 30 days.

Toothpaste — Mimosa pudica

Indications (Toothpaste): gingivitis, periodontitis, stomatitis, oral candidiasis, ulcerative stomatitis, bad breath, tendency to gum bleeding, tooth sensitivity, early-stage caries.

Standard Dosage (Toothpaste): brush teeth 2 times a day in the morning and evening, apply a strip 1.5–2 centimeters long to a toothbrush, brush for 2–3 minutes, then rinse the mouth with water.

Enhanced Dosage (Toothpaste): brush teeth 3 times a day for pronounced inflammatory gum diseases, stomatitis, increased tooth sensitivity.

Maximum Dosage (Toothpaste): up to 4 times a day, for a course of no more than 3 weeks, for active inflammatory processes in the oral cavity.

Preventive Dosage (Toothpaste): brush teeth 1 time a day at night in courses of 1 month every 3–4 months for chronic gingivitis, increased tooth sensitivity, tendency to gum bleeding.

Pediatric Dosage (Toothpaste): for children over 6 years of age — apply a strip of toothpaste 0.5–1 centimeter long 1–2 times a day; for children under 6 years of age — only on the recommendation of a dentist and under adult supervision.

Contraindications (Toothpaste): individual intolerance, acute injuries of the oral mucosa. No scientifically documented contraindications during pregnancy and lactation.

Side Effects (Toothpaste): with excessive use — dryness of the mucous membrane, short-term irritation of the oral mucosa.

Adjustment for Patient Body Weight (Toothpaste): not required.

Preparation method (Toothpaste): Ingredients for 100 grams of product: dry extract of Mimosa pudica — 2 grams, calcium carbonate powder — 40 grams, hydrated silicon dioxide — 15 grams, vegetable glycerin — 20 grams, sorbitol — 10 grams, coconut oil — 5 grams, distilled water — 7 grams, xanthan gum — 0.8 grams, peppermint essential oil — 0.2 grams. Mix the dry components thoroughly, gradually add glycerin and sorbitol, then add water and coconut oil, stirring until a homogeneous paste-like consistency is obtained. Add the essential oil, mix thoroughly, package into sterile tubes.

Storage Conditions and Shelf Life (Toothpaste): store at a temperature of 5 to 25 °C, in tightly closed packaging, away from direct sunlight and heat sources. Shelf life — 12 months, after opening use within 60 days.

Toxicity and biosafety of Mimosa pudica

Toxicity studies of Mimosa pudica indicate that the plant has a low level of acute toxicity. In experimental studies on laboratory animals, it was determined that oral administration of an aqueous extract of Mimosa pudica did not cause lethal outcomes at doses up to 5000 mg/kg body weight, indicating an LD₅₀ value above this level. This classifies the substance as practically non-toxic according to the Hodge and Sterner scale. Chronic toxicological studies also did not reveal significant pathological changes in organs and tissues with long-term use at therapeutic doses. No data on mutagenicity, carcinogenicity, and reproductive toxicity have been found in available sources.

Reference: https://doi.org/10.4103/0974-8...

Pharmacodynamics — Mimosa pudica

The pharmacodynamic properties of Mimosa pudica are determined by a complex of biologically active compounds, including flavonoids, alkaloids, terpenoids, tannins, amino acids, and polysaccharides. The plant exhibits pronounced anti-inflammatory activity associated with the inhibition of the production of pro-inflammatory mediators and a decrease in the expression of enzymes involved in inflammatory reactions. These mechanisms are realized both at the systemic and local levels, affecting immune, nervous, and endocrine regulation.

Sedative and anxiolytic effects have been detected, mediated by the modulation of the activity of GABAergic and serotonergic systems, which leads to a decrease in the excitability of the central nervous system. There is evidence of an effect on nociceptive transmission, which manifests as an analgesic effect with local application.

Antioxidant properties are due to the presence of polyphenolic compounds capable of neutralizing free radicals and suppressing lipid peroxidation, which helps protect cell membranes and stabilize their structure. These effects have been observed both under conditions of systemic exposure and with local application on the skin and mucous membranes.

In the gastrointestinal tract, astringent and spasmolytic effects have been recorded, which are realized through the precipitation of proteins on the surface of the mucous membranes and relaxation of smooth muscles. In addition, a number of plant components have a mild antimicrobial and antiprotozoal effect, associated with the disruption of the integrity of microbial cell membranes and inhibition of their enzymatic activity.

Studies have demonstrated immunomodulatory effects, including the activation of phagocytic activity of macrophages and normalization of the cytokine profile. With external use, the extract helps accelerate reparative processes in the skin by stimulating fibroblast proliferation and collagen synthesis, and also has a keratolytic effect.

Along with this, Mimosa pudica exhibits hypotensive and hypoglycemic effects, which are associated with an effect on the regulation of vascular tone and carbohydrate metabolism. These effects are mediated by a complex effect on endothelial function, receptor systems, and enzymatic cascades.

References: https://doi.org/10.4103/0974-8...    https://doi.org/10.1155/2014/8...

Pharmacokinetics — Mimosa pudica

Data on the pharmacokinetics of Mimosa pudica are limited, but its properties can be assessed based on the known characteristics of its constituent biologically active substances. Following oral administration of powder, dry or alcohol extract, the active components undergo partial absorption in the small intestine. Flavonoids and tannins can bind to food proteins, slowing absorption. Polysaccharides and other high molecular weight compounds mainly act locally in the gastrointestinal lumen, interacting with the microbiota and the mucous barrier.

With transdermal and topical use (ointment, cream, cosmetic composition), the absorption of active substances is limited by the stratum corneum of the skin; penetration is enhanced in the presence of damage or inflammation. When applied to mucous membranes (oral cavity), bioavailability is higher due to rich blood supply and thin epithelial lining.

After absorption, active substances are distributed mainly in the liver, kidneys, spleen, and tissues with a high level of metabolic activity. Some lipophilic compounds are able to penetrate the blood-brain barrier, which explains the effect on the central nervous system.

Metabolism occurs mainly in the liver, with the participation of oxidative, hydrolytic, and conjugation pathways. Some components may undergo microbial metabolism in the intestine with the formation of more or less active metabolites.

Excretion occurs primarily with bile and urine, to a lesser extent — through the skin and lungs. Polysaccharides and other non-absorbable components are excreted in the feces, while performing auxiliary functions in the intestine. With external use, excretion is insignificant and occurs through local metabolic processes in the skin.

References: https://doi.org/10.1155/2014/8...   https://doi.org/10.4103/0974-8...

Mechanisms of Action and Scientific Rationale — Mimosa pudica

The pharmacological action of Mimosa pudica is determined by the multi-target effect of its active compounds, among which are flavonoids, alkaloids, triterpenes, tannins, amino acids, and polysaccharides. The anti-inflammatory effect of the plant is associated with the inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) activity, which leads to a decrease in the synthesis of pro-inflammatory prostaglandins and leukotrienes. Additionally, suppression of the NF-κB signaling cascade and modulation of MAPK pathway activity have been recorded, which limits the transcription of pro-inflammatory cytokine genes, including tumor necrosis factor-α (TNF-α), interleukin-1β, and interleukin-6.

The neurotropic effect is realized through the modulation of GABAergic and serotonergic transmission. Alkaloid fractions of the plant can interact with GABA-A receptors, increasing the flow of chloride ions into neurons and reducing their excitability. An indirect effect on serotonin 5-HT1A receptors and dopamine D2 receptors has been observed, which is associated with anxiolytic and sedative potential.

The antioxidant activity of Mimosa pudica is due to the high content of polyphenols and flavonoids, which neutralize reactive oxygen and nitrogen species, and also increase the expression of antioxidant enzymes, including superoxide dismutase (SOD), catalase, and glutathione peroxidase. These compounds stabilize cell membranes and prevent oxidative degradation of lipids.

The immunomodulatory effect is associated with the activation of the phagocytic function of macrophages and the stimulation of lymphocyte proliferation. Studies have noted an increase in the production of immunoglobulins and normalization of the Th1/Th2 response balance. At the cellular level, a modulating effect on Toll-like receptors (TLR) has been detected, which can correct an excessive or insufficient immune reaction.

The local wound healing and dermatoprotective effect is explained by stimulating the migration of fibroblasts, enhancing the synthesis of collagen and hyaluronic acid, as well as modulating the activity of metalloproteinases involved in the remodeling of the extracellular matrix. Polyphenolic compounds help protect keratinocytes from oxidative stress, and tannins provide an astringent and antimicrobial effect due to protein denaturation and disruption of the integrity of microbial membranes.

References: https://doi.org/10.1155/2014/8...    https://doi.org/10.4103/0974-8...

Synergy — Mimosa pudica

Scientific research shows that Mimosa pudica exhibits pharmacological synergy with a number of taxa and natural compounds, potentiating their effects. In combination with Curcuma longa, an enhancement of the anti-inflammatory effect has been noted due to the combined suppression of the NF-κB cascade and a decrease in COX-2 expression, which leads to an additive and partially potentiating effect. Co-administration with Azadirachta indica enhances the antimicrobial and antiprotozoal effect, probably due to the synchronous damage to the cell membranes of pathogens and inhibition of their enzyme systems.

The combination with Withania somnifera demonstrates synergy in modulating the stress response through an effect on the hypothalamic-pituitary-adrenal axis and increasing resistance to oxidative stress, which is due to the cumulative antioxidant potential. When combined with Ocimum sanctum, an enhancement of the immunomodulatory effect is observed, including the stimulation of natural killer cell activity and normalization of the cytokine profile.

Ethnopharmacological data indicate the traditional combined use of Mimosa pudica with Phyllanthus niruri to enhance the detoxifying effect. In vitro studies confirm that this combination increases the expression of phase II detoxification enzymes in hepatocytes and enhances the antioxidant protection of liver cells.

Potentiation of the analgesic effect has also been detected when combined with Zingiber officinale due to the combined effect on TRPV1 receptors and a decrease in the production of pro-inflammatory mediators. This type of interaction is classified as potentiating, with systemic and tissue-specific action, affecting both central and peripheral mechanisms of pain signal modulation.

References: https://doi.org/10.1155/2014/8...   https://doi.org/10.4103/0974-8...   https://doi.org/10.3390/molecu...

Geography of use and traditional medicine — Mimosa pudica

Mimosa pudica has a wide range of use in the traditional medicine of tropical and subtropical regions of Asia, Africa, Central and South America. In South and Southeast Asia, the plant is known in the Indian Ayurvedic tradition, where it is used in the form of decoctions and pastes for external use, as well as infusions for internal use. In Nepal and India, the leaves and roots are used in the form of compresses and pastes in home healing practices. In Thai traditional medicine, the aerial part of the plant is used, mainly in the form of decoctions, to maintain the general condition of the body. In Philippine ethnomedicine, the plant is found in the form of decoctions and infusions as part of multicomponent mixtures.

In Africa, Mimosa pudica is known in the folk medicine of Nigeria and Cameroon, where its parts are used in the form of ground pastes, fresh juice, and decoctions. In Latin American countries, including Brazil and Peru, the leaves and stems of the plant are part of traditional herbal mixtures used in local healing practices.

Historical mentions of the plant are found in colonial botanical descriptions of the 18th–19th centuries, as well as in early Indian herbal guides, where Mimosa pudica is described as a plant with a peculiar "shy" leaf behavior.

The ethnocultural context of the plant includes its use in ritual practices — in some regions of India and South America, it was considered a protective plant, symbolizing modesty and protection. In a number of traditions, fresh branches or bundles of dry stems were hung in dwellings or places of rituals for "cleansing the space." In some cultures, it was mentioned as an element of ritual baths, wraps, or protective amulets.