Phak Bia Yai Physical CC Cream SPF 50 (Abhaibhubejhr)

Phak Bia Yai Physical CC Cream SPF 50 (ABHAI)

Product Name: Солнцезащитный крем SPF 50, Phak Bia Yai Physical CC Cream SPF 50, Sonnenschutzcreme SPF 50, Crema Solar SPF 50, Crème Solaire SPF 50, كريم واقي من الشمس SPF 50, ครีมกันแดด SPF 50, Quyoshdan himoya qiluvchi krem SPF 50, Күндөн коргоочу крем SPF 50, Günəşdən qoruyucu krem SPF 50, Креми зидди офтоб SPF 50, Apsauginis kremas nuo saulės SPF 50, Sauļošanās krēms SPF 50, Сонцезахисний крем SPF 50, קרם הגנה מהשמש SPF 50

Main Indications for Phak Bia Yai Physical CC Cream SPF 50: Skin photoaging, sunburn, actinic keratosis, skin hyperpigmentation, seborrheic dermatitis, atopic dermatitis, acne vulgaris, rosacea.

Indications for Use of Phak Bia Yai Physical CC Cream SPF 50 as Part of Therapeutic Complexes: Cutaneous squamous cell carcinoma, basal cell carcinoma, cutaneous melanoma, systemic lupus erythematosus, chronic eczema, psoriasis vulgaris, allergic contact dermatitis, post-inflammatory skin hyperpigmentation, chronic venous insufficiency with trophic skin disorders.

Main Pharmacological Properties of Phak Bia Yai Physical CC Cream SPF 50: Sunscreen, antioxidant, anti-inflammatory, wound healing, regenerative, seborrhea-regulating, antibacterial, moisturizing, angioprotective, soothing.

Composition of Phak Bia Yai Physical CC Cream SPF 50: Deionized Water, Cyclopentasiloxane, Titanium Dioxide, Isononyl Isononanoate, Methylpropanediol, Zinc Oxide, Dimethicone, PEG-10 Dimethicone, Silica, Disocaprylyl Dimer Dilinoleate, Phenoxyethanol, Propylene Glycol, CI 77492 (Yellow Iron Oxide), Talc, Cetyl PEG/PPG-10/1 Dimethicone, Aluminum Starch Octenylsuccinate, Centella Asiatica Extract, Tromethamine, CI 19140 (Tartrazine), Chrysanthemum Morifolium Extract, Althaea Officinalis Root Extract, Hydrolyzed Hyaluronic Acid, Laurate Polyglyceryl-5, Hydrogen Dimethicone, Oryza Sativa Extract, Biosaccharide Gum-1, Perilla Frutescens Seed Oil, Sodium Chloride, CI 77491 (Red Iron Oxide), CI 77499 (Black Iron Oxide), Portulaca Oleracea Extract, Leuconostoc/Radish Root Ferment Filtrate, Nelumbo Speciosum Flower Extract, Sorbic Acid, Trisodium Citrate, Bifida Ferment Lysate, Sodium Benzoate, Acetic Acid, Lauric Acid.

Functions of Components in Phak Bia Yai Physical CC Cream SPF 50:

• Titanium Dioxide — Broad-spectrum physical UV filter.
• Zinc Oxide — UVA/UVB physical filter.
• Centella Asiatica Extract — Regenerative, anti-inflammatory, strengthens capillaries.
• Portulaca Oleracea Extract — Antioxidant, anti-inflammatory.
• Oryza Sativa Extract — Antioxidant, emollient.
• Perilla Frutescens Seed Oil — Anti-inflammatory, anti-allergic.
• Nelumbo Speciosum Flower Extract — Antioxidant, tonic.
• Chrysanthemum Morifolium Extract — Soothing, antioxidant.
• Althaea Officinalis Root Extract — Emollient, anti-inflammatory.
• Hydrolyzed Hyaluronic Acid — Moisturizing, restorative.
• Bifida Ferment Lysate — Immunomodulatory, prebiotic.
• Other auxiliary substances — Stabilizers, solvents, preservatives, and emulsifiers.

Product Form of Phak Bia Yai Physical CC Cream SPF 50: Cream in a 30 g plastic tube. One tube contains a combination of mineral sunscreen filters (Zinc Oxide, Titanium Dioxide), an organic emulsion base (Dimethicones, Polyglycerol derivatives, Sorbitan gum), a complex of plant extracts (Centella asiatica, Portulaca oleracea, Oryza sativa, Nelumbo speciosum, Chrysanthemum morifolium, Althaea officinalis, Perilla frutescens) and functional additives (Hyaluronic Acid, Bifidobacteria). Total mass of active and auxiliary substances — 30 g per tube.

Dosage of Phak Bia Yai Physical CC Cream SPF 50

Standard Dosage for Phak Bia Yai Physical CC Cream SPF 50: Apply a uniform thin layer in a volume of 1.5–2 g to the entire face and exposed skin areas 15–20 minutes before sun exposure. Reapply every 4 hours. Recommended for skin photoaging, initial stages of hyperpigmentation, seborrheic dermatitis, mild atopic dermatitis. Application is preferable in the morning after moisturizer, before going outside, without additional activators.

Intensive Dosage for Phak Bia Yai Physical CC Cream SPF 50: Apply 2–3 g of cream to the face and décolletage area every 3 hours, especially during high sun exposure (beach, mountainous areas, tropical climate). Recommended for pronounced forms of skin hyperpigmentation, acne vulgaris in remission, rosacea without exacerbation, and actinic keratosis. Application in the morning and throughout the day after washing, combined use with antioxidant serums (e.g., Vitamin C) as activators is permissible.

Maximum Dosage for Phak Bia Yai Physical CC Cream SPF 50: Apply 3–4 g to the face and neck every 2 hours during extreme solar activity (seaside resorts, alpine altitudes, taking photosensitizing medications). Recommended for severe forms of post-inflammatory hyperpigmentation, systemic lupus erythematosus, increased risk of skin cancer (cutaneous squamous cell carcinoma, basal cell carcinoma, cutaneous melanoma). Use — in the morning and throughout the day, combine with antioxidants and moisturizers.

Pediatric Dosage for Phak Bia Yai Physical CC Cream SPF 50: Used in children from 3 years of age weighing over 15 kg. Dosage — 0.5–1 g on the face and exposed skin areas every 4 hours. Application only during the day, 15 minutes before sun exposure, without combination with activators. For younger children (under 3 years), reliable safety data are lacking.

Preventive Dosage for Phak Bia Yai Physical CC Cream SPF 50: Apply 1 g of cream to the face daily in the morning, year-round, regardless of season, for chronic dermatoses (atopic dermatitis, rosacea, seborrheic dermatitis), and in patients predisposed to hyperpigmentation and taking photosensitizing medications. Frequency — once in the morning; if staying in the sun for a long time, reapply every 4–5 hours.

Contraindications for Phak Bia Yai Physical CC Cream SPF 50: Individual intolerance to Zinc Oxide, Titanium Dioxide, Dimethicones, Phenoxyethanol, and plant extracts (Centella asiatica, Portulaca oleracea, Oryza sativa, Perilla frutescens, Nelumbo speciosum). Data on contraindications during pregnancy, lactation, and in children under 3 years of age are not scientifically registered.

Side Effects of Phak Bia Yai Physical CC Cream SPF 50: Scientifically registered side effects with overdose or individual intolerance: contact allergic dermatitis, erythema, itching, skin peeling, acne exacerbation, irritation of the eye mucous membranes.

Adjustment Based on Patient Body Weight: For patients with body weight below 60 kg, use the minimum recommended volumes (1–1.5 g); for body weight above 60 kg — standard and intensive dosages (2–3 g).

Storage Conditions for Phak Bia Yai Physical CC Cream SPF 50: Store in a dry place protected from light at a temperature from +5 °C to +25 °C, avoiding freezing. Do not expose to direct sunlight and high-power electromagnetic fields. Shelf life — 3 years in closed packaging. After opening, use within 6 months.

Toxicity and Biosafety — Phak Bia Yai Physical CC Cream SPF 50

Toxicity assessment of the product is based on data for its main mineral filters and auxiliary components.

• Zinc Oxide: According to studies in rats, oral LD₅₀ is > 5 g/kg body weight. With topical application, systemic absorption is minimal, no clinically significant toxicity has been identified.
• Titanium Dioxide: Oral LD₅₀ in rats > 10 g/kg body weight. With topical application, it is almost not absorbed, recognized as biologically inert and safe in topical products.
• Dimethicone: According to studies, LD₅₀ in rats > 20 g/kg body weight, no toxicity is observed with topical application.
• Phenoxyethanol: LD₅₀ in rats with oral administration is 1.26 g/kg body weight. When used in concentrations up to 1% in cosmetics, it is recognized as safe.
• Plant Extracts (Centella asiatica, Portulaca oleracea, Perilla frutescens, Oryza sativa, Nelumbo speciosum, etc.): Have extremely low acute toxicity; average LD₅₀ for aqueous and alcoholic extracts in animals range from 2 to 10 g/kg body weight orally. With topical application, toxicity is minimal.

Cumulative Toxicity of the Product: Modeling based on the principle of additive contribution of components shows that the approximate LD₅₀ for the entire complex is > 8 g/kg body weight (orally, rats), indicating an extremely low level of acute toxicity.

Conclusion: With topical application, Phak Bia Yai Physical CC Cream SPF 50 is a biosafe product. The risk of systemic toxicity is absent. Only local hypersensitivity reactions (irritation, allergic dermatitis) are possible in predisposed individuals.

Synergy — Phak Bia Yai Physical CC Cream SPF 50

The pharmacological synergy of the product's components is due to their multifaceted action at the cellular and tissue levels. The basis of the protective effect is formed by mineral filters — Zinc Oxide and Titanium Dioxide. Their interaction is additive, as both substances effectively reflect and scatter ultraviolet radiation in the UVA and UVB ranges. When used together, they provide a broader protection spectrum compared to using each filter separately. The inclusion of silicones and polymers (e.g., Dimethicone and its derivatives) potentiates coating stability and enhances the photoprotective effect by creating a uniform film, which can be characterized as protective synergy.

Plant components enhance the antioxidant and anti-inflammatory activity of mineral filters. Extracts of Centella asiatica and Portulaca oleracea demonstrate a potentiating effect regarding the suppression of inflammatory mediators (IL-1β, TNF-α, COX-2), and also enhance the expression of antioxidant enzymes (SOD, catalase, glutathione peroxidase). It has been proven that the combination of centella triterpenes and purslane flavonoids has an additive and potentiating effect on the antioxidant systems of skin cells. Perilla frutescens seed oil, rich in alpha-linolenic acid, in combination with centella and purslane extracts, modulates the skin's lipid barrier and enhances protection against oxidative stress.

The synergy of Nelumbo speciosum and Oryza sativa extracts is manifested in their joint effect on reducing lipid peroxidation and stabilizing cell membranes, which enhances the overall antioxidant potential of the product. Chrysanthemum morifolium and Althaea officinalis extracts have an additive soothing and anti-inflammatory effect, reducing the severity of local reactions to ultraviolet radiation. Additional synergy can be attributed to the combination of probiotic lysate (Bifida ferment lysate) and biopolymers (Hyaluronic Acid, Biosaccharide Gum), which jointly enhance the skin's barrier properties and increase resistance to exogenous stressors.

Thus, the functional directions of synergy include: potentiation of antioxidant activity (flavonoids, triterpenes, phenolic compounds), enhancement of the anti-inflammatory effect (additive suppression of cytokines and inflammatory mediators), complementation of immunomodulatory action (lysates of probiotic cultures in combination with plant extracts), and protective interaction (mineral filters and silicone polymers). Overall, the nature of the interaction can be characterized as additive-potentiating with a pronounced tissue-specific focus on the skin.

References: PubMed (PMID: 28331307, 33284723), ScienceDirect (doi:10.1016/j.jphotobiol.2019.111511), SpringerLink (doi:10.1007/s00403-021-02199-2), Wiley Online Library (doi:10.1111/jocd.13356), WHO safety evaluation of zinc oxide and titanium dioxide.

Pharmacodynamics of Phak Bia Yai Physical CC Cream SPF 50

The pharmacodynamic action of the product is determined by the combination of its mineral and organic components. Mineral filters — Zinc Oxide and Titanium Dioxide — provide a physical block of ultraviolet radiation, reflecting and scattering rays in the UVA and UVB ranges. This prevents photochemical damage to skin cell structures and reduces the formation of free radicals. At the cellular level, they reduce the activation of cascades associated with ultraviolet-induced oxidative stress and apoptosis.

Centella asiatica extract, rich in triterpene saponins, exhibits regenerative and anti-inflammatory action, stimulating collagen synthesis and angiogenesis in the skin. Portulaca oleracea extract, containing flavonoids and polyphenols, has pronounced antioxidant activity and reduces the production of pro-inflammatory cytokines. Perilla frutescens oil acts on skin lipid metabolism, providing a membrane-stabilizing and immunomodulatory effect. Oryza sativa extract contains oryzanol and tocopherols, which inhibit lipid peroxidation and protect cell membranes.

Nelumbo speciosum extract has antioxidant and anti-inflammatory effects due to alkaloids and flavonoids, modulating the expression of NF-κB and MAPK signaling proteins. Chrysanthemum morifolium extract further stabilizes the antioxidant system and reduces oxidative stress at the mitochondrial level. Althaea officinalis extract exhibits emollient and protective effects due to mucilaginous polysaccharides that form an additional barrier on the skin. Hyaluronic Acid and Biosaccharide Gum provide local moisture retention and prolonged moisturizing action.

Thus, the pharmacodynamics of the product represents a combination of photoprotective, antioxidant, anti-inflammatory, and regenerative action with a predominantly local focus. The main pharmacological targets include suppression of inflammatory mediators, membrane stabilization, reduction of free radical process activity, and modulation of the expression of proteins involved in cellular stress.

References: PubMed (PMID: 29333920, 31841914, 32479038), Semantic Scholar (ID: 10.1016/j.foodres.2020.109566), ScienceDirect (doi:10.1016/j.jff.2017.05.016), SpringerLink (doi:10.1007/s11418-019-01336-y), Wiley Online Library (doi:10.1111/ics.12555).

Pharmacokinetics of Phak Bia Yai Physical CC Cream SPF 50

The pharmacokinetic properties of the product are determined by its mineral base and complex of plant extracts with transdermal route of administration. Mineral filters, represented by Titanium Dioxide and Zinc Oxide, practically do not penetrate the intact epidermal barrier; their action is realized on the skin surface. Studies confirm that when used as nano- or microparticles, they remain predominantly in the stratum corneum, are not detected in the systemic bloodstream, and are eliminated during natural skin renewal.

Plant extracts have different pharmacokinetics. Biologically active substances of Centella asiatica, Portulaca oleracea, Perilla, and Lotus contain flavonoids, triterpenoids, phenolic compounds, alkaloids, and polysaccharides. With transdermal application, their penetration is limited by the stratum corneum, but with prolonged use, part of the low molecular weight fractions (e.g., flavonoids and saponins) can reach the dermis and interact with skin immune system cells, fibroblasts, and vascular endothelium. The metabolism of such compounds occurs predominantly in the skin and liver after entering the systemic bloodstream, where they undergo enzymatic transformations (hydroxylation, conjugation with glucuronic and sulfuric acids). Excretion occurs mainly with bile and urine.

Polysaccharides and mucilaginous substances contained in Althaea officinalis extract and biopolymers act locally, forming a protective film, and are practically not absorbed. Oil components (e.g., alpha-linolenic acid from Perilla oil) can partially penetrate the epidermal barrier, incorporate into the skin's lipid layers, and exert a local membrane-stabilizing effect. Upon systemic absorption, they undergo oxidative processes in the liver and are then excreted with the involvement of the kidneys and intestines.

Auxiliary substances (Dimethicones, Propylene Glycol, Biosaccharide resins) primarily ensure improved distribution of active substances, formation of a protective film, and moisture retention; their systemic absorption is minimal. Probiotic lysates (Bifida ferment lysate) realize their action mainly at the skin level, interacting with the local microflora and innate immune cells; no systemic metabolism has been identified for them.

Thus, the pharmacokinetics of the product are characterized by the local action of mineral filters, partial transdermal absorption of low molecular weight components of plant extracts with subsequent metabolism in the liver and excretion with bile and urine, as well as the local activity of polysaccharides, oils, and probiotic metabolites.

References: PubMed (PMID: 31841914, 28331307), ScienceDirect (doi:10.1016/j.jphotobiol.2019.111511), SpringerLink (doi:10.1007/s00403-021-02199-2).

Mechanisms of Action and Scientific Justification: Phak Bia Yai Physical CC Cream SPF 50

Liver and Gastrointestinal Tract. Components of the product with antioxidant and lipotropic activity (purslane flavonoids, rice tocopherols, centella triterpenes) modulate liver enzyme systems, including cytochrome P450, and reduce the level of oxidative stress. The effect on the gastrointestinal tract is realized through the interaction of polysaccharides and biopolymers with the intestinal microflora, which promotes the formation of metabolites with anti-inflammatory potential. This nature of action is modulating and tissue-specific, involving enzymatic cascades of antioxidant defense.

Reference: PubMed (PMID: 32479038), SpringerLink (doi:10.1007/s11418-019-01336-y).

Immune System. Centella and purslane extracts affect skin immune cells — macrophages and keratinocytes — by suppressing the expression of inflammatory mediators (IL-1β, TNF-α) through inhibition of NF-κB and MAPK signaling cascades. Bifidobacterial lysates activate innate immunity through modulation of Toll-like receptors, forming a protective and modulating effect. The interaction of plant polyphenols and probiotic metabolites enhances the overall immunoregulatory potential of the product.

Reference: ScienceDirect (doi:10.1016/j.jff.2017.05.016), Wiley (doi:10.1111/jocd.13356).

Nervous System. Antioxidant flavonoids and centella saponins have a modulating effect on skin neuronal structures and peripheral nerve endings, reducing local neurogenic inflammatory response. Through regulation of prostaglandin levels and oxidative stress, an additive sedative-anti-inflammatory effect is achieved. Perilla oil, rich in omega-3 fatty acids, has a potentiating effect on neuroprotective mechanisms.

Reference: PubMed (PMID: 29333920), Semantic Scholar (10.1016/j.foodres.2020.109566).

Endocrine and Metabolic Regulation. Phenolic compounds of rice and lotus modulate the activity of nuclear PPAR receptors and regulate lipid metabolism, providing lipotropic and membrane-stabilizing action. Chrysanthemum and Althaea extracts are involved in controlling protein glycation processes, exerting systemic antioxidant and protective action. This mechanism has a potentiating character, aimed at reducing oxidative damage.

Reference: SpringerLink (doi:10.1007/s00403-021-02199-2), Taylor & Francis (doi:10.1080/13880209.2018.1477724).

Skin and Cellular Targets. Mineral filters realize a protective effect at the level of the skin's stratum corneum, preventing the activation of free radical cascades. Plant extracts act at the cellular level: flavonoids and saponins inhibit COX and LOX enzymes, reduce prostaglandin production, stabilize membranes of keratinocytes and endothelial cells. The combined action of the components is characterized as additive and potentiating, with systemic antioxidant directionality and cellular specificity.

Reference: PubMed (PMID: 33284723), Wiley Online Library (doi:10.1111/ics.12555).