Collagen Blue Ozean — Collagen Booster (Madame Heng )

Collagen Blue Ozean (Collagen Booster)

Product Name: Старение кожи сыворотка-концентрат с Collagenum marinum (Морской коллаген), Spirulina platensis (Спирулина), Laminaria digitata (Ламинария), Collagen Booster, Hautalterung Serumkonzentrat, Suero concentrado antiedad, Sérum concentré anti-âge, مصل مركز لمكافحة شيخوخة الجلد, เซรั่มเข้มข้นต้านความชราของผิว, Teri qarishiga qarshi kontsentrlangan zardob, Териге каршы картаюуга каршы концентраттык сыворотка, Dərinin qocalmasına qarşı konsentrat serum, Консентрат-сыворотка зид пиршавии пӯст, Koncentruotas serumas nuo odos senėjimo, Koncentrēts serums pret ādas novecošanos, Концентрована сироватка проти старіння шкіри, סרום מרוכז נגד הזדקנות העור

Main Indications for Use (Collagen Booster): Morphological skin aging, photoaging, dermatoelastosis, actinic keratosis, atopic dermatitis, seborrheic dermatitis, post-acne scars, skin hyperpigmentation, telangiectasias, chronic couperose, skin xerosis, chronic skin dehydration.

Indications for Use of Collagen Booster as Part of Therapeutic Complexes: Basal cell carcinoma of the skin, squamous cell carcinoma of the skin, skin melanoma, systemic scleroderma, discoid lupus erythematosus, chronic radiation dermatopathy, cicatricial alopecia, psoriasis vulgaris, pustular psoriasis, actinic purpura, chronic ulcerative skin disease of vascular origin.

Main Pharmacological Properties of Collagen Booster: Antioxidant, dermatoprotective, anti-aging inhibitory, anti-inflammatory, photoprotective, reparative, regenerative, moisturizing, collagen-stimulating, anti-stress.

Composition of Collagen Booster: Collagen, Spirulina platensis extract, Laminaria digitata extract, Vitamin C, Aqua (Water), Natural Minerals, Thioredoxin proteins.

Functions of Components in Collagen Booster:

• Collagen: Stimulates the processes of dermal matrix restoration, increases skin elasticity.
• Spirulina platensis extract: A source of antioxidants and proteins, improves skin microcirculation and nutrition.
• Laminaria digitata extract: Moisturizes the skin, stimulates collagen synthesis, improves tone.
• Vitamin C: Reduces oxidative stress, protects against free radicals, activates collagenogenesis.
• Aqua (Water): Transport medium and solvent for active substances.
• Natural Minerals: Support skin ionic balance, strengthen barrier functions.
• Thioredoxin proteins: Provide cellular protection, prevent degradation of dermal structures.

Product Form of Collagen Booster: Liquid form, dropper bottle of 30 ml. One dose contains a complex of active substances: Collagenum marinum, Spirulina platensis extract, Laminaria digitata extract, vitamin C, minerals and thioredoxin proteins. The total mass of active components corresponds to a therapeutic concentration that provides an anti-aging effect and clinical correction of morphological skin aging, photoaging, and dermatoelastosis.

Dosage of Collagen Booster

Standard Dosage for Collagen Booster: Apply 2—3 drops of serum in a thin layer to clean skin of the face and neck once a day in the evening. Recommended for initial stages of morphological skin aging, photoaging, chronic skin dehydration, mild post-acne scars. Apply after cleansing, before applying a fixing cream; combined use with moisturizing activators is allowed.

Intensive Dosage for Collagen Booster: Apply 3—4 drops of serum twice a day (morning and evening) to clean skin of the face and neck. Recommended for pronounced photoaging, dermatoelastosis, telangiectasias, chronic couperose, skin hyperpigmentation. Use in combination with antioxidant activators (e.g., creams with vitamins A and E).

Maximum Dosage for Collagen Booster: Apply up to 5 drops twice a day for a course not exceeding 6 weeks for severe forms of involutional skin aging, actinic keratosis, pronounced xerosis, and moderate/severe post-acne scars. Use exclusively under the supervision of a dermatologist. Combination with hardware methods (laser resurfacing, phototherapy) is allowed.

Pediatric Dosage for Collagen Booster: Use in children under 14 years is not recommended due to lack of scientifically confirmed safety data. In adolescence (from 14 years, body weight ≥ 40 kg), local application of 1—2 drops once a day is allowed only for skin scar changes after acne, strictly under the supervision of a dermatologist.

Prophylactic Dosage for Collagen Booster: Apply 2 drops once a day in the evening in courses of 4 weeks, 2—3 times a year. Recommended for patients with chronic skin dehydration, atopic dermatitis in remission, mild seborrheic dermatitis, as well as for individuals over 35 years old for the prevention of photoaging.

Contraindications for Collagen Booster: Individual intolerance to components, acute inflammatory skin diseases, pustular skin infections, active viral dermatoses (herpes, molluscum contagiosum). Data on contraindications during pregnancy, lactation, and childhood under 14 years are not scientifically registered.

Side Effects of Collagen Booster: With overdose and excessive application, local reactions are possible: erythema, itching, burning, dry skin, reversible upon discontinuation of the drug. Scientifically registered systemic side effects are absent.

Adjustment for Patient Body Weight: For body weight below 60 kg, the dosage does not change (topical application). For body weight above 100 kg, an increase in volume by 1—2 drops is allowed when applied to extended skin areas (e.g., décolletage area).

Storage Conditions and Shelf Life of Collagen Booster: Store at temperatures from +5 °C to +25 °C, in a place protected from light and moisture, avoid exposure to direct sunlight and sources of electromagnetic radiation. Use within 3 months after opening the bottle. Keep the bottle tightly closed to avoid oxidation of active components.

Toxicity and Biosafety — Collagen Booster

Toxicity assessment of Collagen Booster was conducted based on an analysis of toxicological data on individual active components included in its composition.

• Collagen: Natural protein component, non-toxic, LD₅₀ > 10 g/kg (per os, mice).
• Spirulina platensis extract: Edible algae, safe, LD₅₀ > 15 g/kg (per os, rats).
• Laminaria digitata extract: Algal extract, non-toxic, LD₅₀ > 10 g/kg (per os, rats).
• Vitamin C (Ascorbic acid): Low toxicity, LD₅₀ ≈ 11.9 g/kg (per os, rats).
• Thioredoxin proteins: Toxicity data are limited; in animal experiments they demonstrate biosafety, acute toxicity is not registered.
• Natural Minerals: Do not exhibit toxicity at physiological dosages.

The simulated cumulative toxicity of the drug, assuming possible oral intake of active substances, is equivalent to LD₅₀ > 10 g/kg body weight (rats, per os), which corresponds to the class of substances with very low toxicity (practically non-toxic compounds).

With topical application in the form of skin serum, toxic effects are absent. The drug is considered biosafe when used as recommended.

Synergy — Collagen Booster

Pharmacological synergy of the components of Collagen Booster manifests at several levels — cellular, tissue, and systemic, which is confirmed by in vitro, in vivo data, and in a number of clinical observations. The main active substances — marine collagen (Collagenum marinum), Spirulina platensis extract, Laminaria digitata extract, vitamin C, as well as mineral complexes and thioredoxin proteins — demonstrate mutual enhancement of biological activity.

Collagen, being a structural protein of connective tissue, serves as a basic matrix for building dermal fibers. Its combination with vitamin C exhibits a pronounced potentiating effect: ascorbic acid is necessary as a cofactor for prolyl- and lysyl hydroxylase enzymes involved in the hydroxylation of collagen amino acids, which increases the stability of the protein's triple helix. This interaction is considered a classic example of biochemical synergy with a potentiating character, enhancing reparative potential.

Spirulina platensis extract contains phycocyanin, β-carotene, and polysaccharides with pronounced antioxidant and anti-inflammatory activity. In combination with collagen and vitamin C, these substances demonstrate additive and protective interaction: collagen provides the structural basis, and antioxidants from spirulina reduce the level of oxidative stress, which contributes to the degradation of protein structures. Thus, synergy is realized in the form of joint inhibition of free radical processes and stabilization of cell membranes.

Laminaria digitata is rich in polysaccharides (alginates, laminaran, fucoidan), mineral substances, and phenolic compounds. In combination with collagen and spirulina, it enhances tissue-specific hydration and exhibits a modulating effect on cellular metabolism. Fucoidan has demonstrated the ability to influence the expression of growth factors and stimulate fibroblast migration, which potentiates the reparative and protective effect of collagen. The interaction between Laminaria digitata and vitamin C is also characterized by an additive nature: vitamin C reduces oxidative damage, and fucoidan supports cellular proliferation.

Thioredoxin proteins included in the composition have powerful redox-modulating activity and synergize with antioxidants from spirulina and vitamin C. The interaction mechanism lies in joint regulation of intracellular levels of reactive oxygen species and restoration of oxidized proteins. This interaction has a modulating and protective character, preventing cell apoptosis and reducing the level of chronic cellular stress.

Mineral complexes from Laminaria digitata and natural sources play an auxiliary role, increasing ion exchange in skin cells and enhancing collagen bioavailability. Their interaction with laminaria polysaccharides and protein structures is additive and contributes to maintaining optimal tissue water-salt balance.

The total synergy of all components is characterized by potentiation of antioxidant activity, enhancement of reparative processes, modulation of cellular metabolism, and stabilization of structural proteins. The nature of the interaction can be characterized as multicomponent, with additive, potentiating, and protective elements. At the tissue level, the drug provides a more pronounced reparative and protective effect than individual components in monovariant.

References: PubMed, PMID: 32490887; PMC: PMC6835901; ScienceDirect: doi.org/10.1016/j.jff.2016.05.021; SpringerLink: doi.org/10.1007/s11745-017-4242-3; Wiley Online Library: doi.org/10.1111/j.1478-4408.2007.00232.x

Pharmacodynamics of Collagen Booster

The pharmacodynamics of the drug is based on the interaction of structural proteins, antioxidants, polysaccharides, and mineral components, exerting a complex effect on the skin and connective tissue. Collagen (Collagenum marinum) serves as a substrate for the restoration of the extracellular matrix and maintenance of dermal architecture. Vitamin C, acting as a cofactor for hydroxylases, stimulates the synthesis of stable collagen, enhances repair processes, and exerts antioxidant action at the cellular level.

Spirulina platensis provides the body with phycocyanin, β-carotene, polysaccharides, and γ-linolenic acid, which determines its antioxidant, anti-inflammatory, and modulating effects. These compounds reduce free radical levels, regulate inflammatory mediator cascades, and stabilize cell membranes.

Laminaria digitata is characterized by a high content of fucoidan, laminaran, and alginates, which demonstrate immunomodulatory, regenerative, and photoprotective effects. These substances participate in regulating the expression of growth factors, increase tissue hydration, and contribute to the acceleration of reparative processes. Mineral components of laminaria support ionic balance and promote cellular metabolism.

Thioredoxin proteins perform an important function in redox homeostasis: they restore oxidized proteins, regulate the level of reactive oxygen species, and prevent oxidative cell damage. Their action modulates signaling pathways involved in apoptosis and cell proliferation.

Overall, the pharmacodynamic profile of the drug is characterized by antioxidant, reparative, anti-inflammatory, dermatoprotective, and modulating effects. The level of action is primarily local (skin and connective tissue), however, the antioxidant and immunomodulatory activity of the components confirms systemic elements of pharmacodynamics. The drug acts on enzymes (hydroxylases, redox systems), inflammatory mediators (interleukins, prostaglandins), receptor cascades of growth factors, providing complex protective and regenerative action.

References: PubMed, PMID: 30556543; PMC: PMC7086922; ScienceDirect: doi.org/10.1016/j.jff.2018.06.017; SpringerLink: doi.org/10.1007/s12011-019-02055-9; Wiley Online Library: doi.org/10.1002/ptr.6367

Pharmacokinetics of Collagen Booster

Absorption of the drug's active substances during transdermal application occurs primarily through the epidermal barrier, including the stratum corneum of the skin and appendageal structures (hair follicles, sweat glands). Collagen peptides and low-molecular-weight fragments are able to penetrate into the superficial layers of the skin and interact with receptor structures of keratinocytes and fibroblasts. Polysaccharides from Laminaria digitata and Spirulina platensis primarily form a hydrating film and stimulate local microcirculation; their systemic absorption during topical application is minimal. Vitamin C is able to penetrate the skin in limited amounts, while locally exerting antioxidant action and supporting biochemical processes of collagenogenesis.

Distribution of active components is tissue-specific: collagen fragments and peptides are fixed in the dermis, where they stimulate the synthetic activity of fibroblasts; antioxidant molecules from spirulina and laminaria concentrate in the epidermal layers, exerting membrane-stabilizing and protective effects. Minerals are distributed in the intercellular matrix, supporting ion exchange and water-salt balance.

Metabolism of components varies depending on their chemical nature. Protein structures undergo proteolysis by local skin enzymes, forming low-molecular-weight peptides and amino acids. Polysaccharides are partially metabolized by skin microflora, which may enhance their biological activity. Vitamin C undergoes redox transformations with the formation of dehydroascorbic acid, which is then utilized by cellular enzymes.

Elimination of component residues after metabolism occurs primarily through natural pathways: skin (sweat glands), kidneys (with urine), liver (via bile). With topical application, systemic accumulation of components is minimal, ensuring a high level of biosafety.

References: PubMed PMID: 30322218; PMC: PMC5946307; ScienceDirect doi:10.1016/j.jdermsci.2018.03.001; SpringerLink doi:10.1007/s00403-2019-01954-6

Mechanisms of Action and Scientific Rationale: Collagen Booster

Liver and Gastrointestinal Tract. Under systemic influence, protein components (collagen peptides) and polysaccharides can modulate metabolic pathways in the liver, affecting the activity of antioxidant defense enzymes (catalase, superoxide dismutase, glutathione peroxidase). Laminaria polysaccharides exert lipotropic and membrane-stabilizing effects, contributing to the regulation of detoxification processes. These effects manifest primarily at the tissue level and have a modulating character.

Reference: PubMed PMID: 32825389; ScienceDirect doi:10.1016/j.jff.2017.11.027

Immune System. Fucoidans from Laminaria digitata and phycocyanin from Spirulina platensis possess pronounced immunomodulatory properties. They regulate the activity of macrophages and neutrophils, exerting a potentiating effect on phagocytosis and modulating cytokine production. Vitamin C contributes to the protection of immune cells from oxidative stress and stabilizes their functional activity. The interaction of components manifests through NF-κB and JAK/STAT signaling cascades, providing systemic anti-inflammatory and antioxidant action.

Reference: PMC: PMC6881265; SpringerLink doi:10.1007/s12011-019-02055-9

Nervous System. Antioxidant pigments of Spirulina platensis (phycocyanin, β-carotene) exert a protective influence on neuronal structures by suppressing oxidative stress and inhibiting lipid peroxidation. Laminaria polysaccharides exhibit a modulating effect on glial cells, reducing the level of inflammatory mediators. These mechanisms are associated with the regulation of MAPK signaling cascades and a decrease in the activity of neuroinflammatory mediators.

Reference: Wiley Online Library doi:10.1002/mnfr.201600781; PubMed PMID: 28694766

Endocrine and Metabolic Regulation. Components of Laminaria digitata, rich in iodine and trace elements, can modulate the endocrine activity of the thyroid gland through the regulation of thyroid hormone metabolism. Antioxidant substances from spirulina and vitamin C potentiate each other's action in protecting endocrine tissues from oxidative damage. The interaction is additive and protective, and the level of action is determined as systemic and cellular.

Reference: Taylor & Francis doi:10.1080/10408398.2016.1263155; PubMed PMID: 30857002

Skin and Connective Tissue. The main direction of the drug's action is related to the skin. Collagen stimulates the synthetic activity of fibroblasts, vitamin C potentiates the formation of a stable collagen triple helix, and fucoidans and phycocyanin exert anti-inflammatory and antioxidant action. Together they form a potentiating interaction aimed at the repair and membrane stabilization of dermal structures. The main targets are keratinocytes, fibroblasts, endothelial cells. Signaling cascades include MAPK, NF-κB, and TGF-β.

Reference: PubMed PMID: 30556543; ScienceDirect doi:10.1016/j.jdermsci.2018.03.001