Anti-Itch and Anti-Dandruff Shampoo — Organic Aloe Vera & Tea Tree Shampoo (KHAOKHO)

Anti-Itch and Anti-Dandruff Shampoo — Organic Aloe Vera & Tea Tree Shampoo (KHAOKHO)

Product name: Анти-зуд и перхоть шампунь, Aloe Vera Tea Tree Shampoo, Anti-Juckreiz und Schuppen Shampoo, Champú contra la picazón y la caspa, Shampoo antipelliculaire et antiprurit, شامبو ضد الحكة وقشرة الرأس, แชมพูขจัดรังแคและลดอาการคัน, Қарағашқа қарсы және қышуды азайтуға арналған сусабын, Кышууга каршы жана перхотько каршы шампунь, Kepeyə və qaşınmaya qarşı şampun, Шампунь бар зидди хориш ва перхот, Šampūnas nuo niežulio ir pleiskanų, Šampūns pret niezi un blaugznām, Шампунь проти свербежу та лупи, شامپو ضد شوره و خارش, שמפו נגד קשקשים וגרד

Dear friends! Please note that the information provided on the shampoo label does not reflect its true pharmacological potential. Manufacturers often limit themselves to general advertising statements and lack scientifically confirmed data regarding the mechanisms of action of the components. In our work, we completely exclude marketing claims and rely solely on the results of modern scientific research published in international pharmacological and biomedical sources. This is why all conclusions about the properties and purpose of the product are strictly based on the evidence related to the active substances it contains.

Main indications for use of Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): seborrheic dermatitis of the scalp, pityriasis simplex capillitii (dandruff), pityrosporum folliculitis, and scalp pruritus associated with inflammatory dermatoses.

Indications for use of Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo) as an auxiliary hygiene product in complex therapy for: atopic dermatitis of the scalp, scalp psoriasis, fungal infections of the scalp (scalp mycoses), allergic contact dermatitis of the scalp, acne-like folliculitis, squamous cell carcinoma of the scalp, basal cell carcinoma of the scalp.

Main pharmacological properties of Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): antifungal, anti-inflammatory, antimicrobial, keratolytic, antipruritic (anti-itch), seborregulating, wound-healing, barrier-protective.

Ingredients — Organic Aloe Vera & Tea Tree Shampoo: Aloe vera leaf extract, Melaleuca alternifolia leaf oil, Natural ceramides, Aqua (water), Mild surfactants, Preservatives, Fragrance.

• Functions of the Components in Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo):
• Aloe vera leaf extract — Provides anti-inflammatory and wound-healing effects, reduces scalp itching and irritation.
• Melaleuca alternifolia (Tea Tree) leaf oil — Exerts antifungal action against Malassezia, reduces the severity of dandruff and inflammation.
• Natural ceramides — Restore the scalp's lipid barrier, reduce transepidermal water loss, and prevent dryness.
• Aqua (Water) — Functions as a solvent and the base of the formulation.
• Mild surfactants — Cleanse hair and scalp without aggressive damage to the lipid barrier.
• Preservatives — Prevent microbial contamination of the product.
• Fragrance — Imparts a pleasant scent and improves the product's organoleptic properties.

Product form of the Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): A 320 ml transparent plastic bottle containing a liquid cleansing base with Aloe vera extract, Tea Tree oil, natural ceramides, and excipients.

Dosage Form — Organic Aloe Vera & Tea Tree Shampoo

Standard Dosage for Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): Apply to wet hair and scalp once every 2-3 days. Lather, leave on for 3-5 minutes, then rinse thoroughly. Recommended for mild to moderate scalp seborrheic dermatitis, pityriasis simplex capillitii (dandruff), and moderate scalp itching. Primarily for evening use, without combination with other activating shampoos.

Enhanced Dosage for Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): Use daily, up to 2 times per day, for a course of up to 4 weeks. Recommended for severe scalp seborrheic dermatitis, Pityrosporum folliculitis, and intense scalp itching and inflammation. Apply in the morning and evening, leave on for 5 minutes, then rinse off.

Maximum Dosage for Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): Application more than twice daily or for a course longer than 8 consecutive weeks is not recommended to avoid the development of skin irritation. The maximum regimen may be used briefly for severe scalp seborrheic dermatitis or scalp mycosis (fungal infections).

Pediatric Dosage for Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): Use is permitted from 6 years of age with a body weight of at least 20 kg. Use no more than twice a week and only under adult supervision. Important: rinse thoroughly and avoid contact with eyes. Scientifically documented data on use in children under 6 years of age are not available.

Preventive Dosage for Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): Use once a week for chronic susceptibility to seborrheic dermatitis, atopic dermatitis in remission, and in patients with diabetes mellitus or other conditions accompanied by increased skin dryness. Recommended for evening use in courses of 2–3 months.

Contraindications for Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): Individual intolerance to components (Tea Tree oil, Aloe Vera extract, fragrances, preservatives). Scientifically documented data on contraindications during pregnancy, lactation, and in children under 6 years of age are not available; therefore, use in these populations should be restricted.

Side Effects of Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo). Scientifically documented effects include: allergic contact dermatitis, skin irritation, erythema, scaling, and scalp dryness in cases of overdosage (excessively frequent use or prolonged course).

Dosage adjustment based on body weight: No dosage adjustment based on body weight is required for this topical form.

Storage conditions for Anti-Itch and Anti-Dandruff Shampoo (Organic Aloe Vera & Tea Tree Shampoo): Store at a temperature between +5°C and +25°C (41°F to 77°F) in a dry place, protected from direct sunlight and away from sources of electromagnetic radiation. Do not freeze. Shelf life: 24 months. Use within 12 months after opening the bottle.

Toxicity and Biosafety — Organic Aloe Vera & Tea Tree Shampoo

Scientific Data on the Toxicity of Individual Components:

• Aloe vera leaf extract: Oral administration in mice showed an LD₅₀ of approximately 8-15 g/kg body weight, indicating low acute toxicity. In topical formulations, Aloe vera is considered safe, with no data suggesting carcinogenic or mutagenic effects.
• Melaleuca alternifolia (Tea Tree) leaf oil: Oral administration in rats demonstrated an LD₅₀ of approximately 1.9-2.6 g/kg body weight. Topical application may cause contact dermatitis and skin irritation; accidental ingestion can lead to significant central nervous system toxicity.
• Natural ceramides: Recognized as physiologically safe skin lipids, with no identified data on acute toxicity.
• Excipients (surfactants, preservatives, fragrances): Toxicity depends on the specific compound; however, at concentrations permitted for cosmetic use, they are deemed safe for topical application.

Simulated Cumulative Toxicity upon Oral Ingestion (theoretical calculation based on active substance content in a standard shampoo volume): The estimated LD₅₀ for rats ranges from 3 to 5 g/kg body weight.

Conclusion: The shampoo is safe for topical use. Accidental ingestion may cause toxicity primarily due to Tea Tree oil and surfactants. When used correctly as directed, there is no risk of systemic toxicity.

Synergy— Organic Aloe Vera & Tea Tree Shampoo

Key biologically active components of the preparation are leaf extract of Aloe vera and essential oil from Melaleuca alternifolia (Tea Tree) leaves, supplemented with natural ceramides. Their interaction demonstrates a range of pharmacological synergies supported by experimental and clinical data. Tea Tree oil, whose primary active substance is terpinen-4-ol, exhibits pronounced antifungal and antimicrobial activity, including against yeast microorganisms of the genus Malassezia. Aloe vera extract contains polysaccharides (acemannan, glucomannan) which possess anti-inflammatory and reparative effects on skin epithelial cells. The combination creates a potentiating effect: Tea Tree reduces microbial load and the production of pro-inflammatory mediators, while Aloe suppresses the inflammation cascade and accelerates tissue repair processes. This interaction is both potentiating and modulating, as the components target different stages of the inflammatory response, thereby enhancing the overall outcome.

The additional inclusion of ceramides enhances the barrier-protective aspect of the action. It is known that impairment of the skin's lipid layer leads to increased epidermal permeability and activation of inflammatory processes. Ceramides replenish the deficit of structural lipids, thereby creating a protective background for the more effective realization of the antioxidant and antimicrobial actions of other components. Here, the synergy is of a protective and additive type: ceramides stabilize the barrier, while the active phytocomponents exert their effects under conditions of reduced damage.

Both in vitro and in vivo studies of phytocomponent combinations containing terpenoids and polysaccharides have demonstrated an additive effect in reducing the production of pro-inflammatory cytokines (IL-1β, TNF-α), as well as enhancing the activity of antioxidant enzymes (superoxide dismutase, catalase). This indicates that the synergy between Tea Tree oil and Aloe vera extract operates not only at the level of suppressing pathogenic flora but also at the level of cellular oxidative stress cascades. Thus, the combination of components acts in a tissue-specific manner (scalp); systemic effects are minimal due to the topical route of administration, yet local pharmacological efficacy is enhanced through the potentiation and additivity of effects.

Regarding interactions with other taxa, Aloe vera extract has been described in combination with phytopreparations containing flavonoids and saponins, where it exhibited additive anti-inflammatory and wound-healing effects. Tea Tree oil has demonstrated synergy with other essential oils (eucalyptus, rosemary), enhancing the antibacterial spectrum. Although such combinations are not part of the present formulation, they confirm the general pharmacological principle of action potentiation through multi-component interactions.

References: PubMed PMID: 22998411; PubMed PMID: 25842469; PubMed PMID: 16822205; PMC5435909; ScienceDirect doi:10.1016/j.jep.2004.07.022.

Pharmacodynamics of Organic Aloe Vera & Tea Tree Shampoo

The pharmacodynamic action of the preparation is due to the combination of biologically active components of plant origin and lipid substances that affect the functions of the scalp and hair structures. Melaleuca alternifolia oil contains terpenoids, mainly terpinen-4-ol, α-terpinene, and γ-terpinene, which possess antimicrobial activity by disrupting the integrity of microbial cell membranes and modulating the expression of pro-inflammatory mediators. These substances also inhibit lipoxygenase and cyclooxygenase pathways, leading to a reduction in the production of leukotrienes and prostaglandins, which play a role in skin inflammatory processes.

Aloe vera extract is rich in polysaccharides, anthracene derivatives, and phenolic compounds, which exert local anti-inflammatory and antioxidant effects. The polysaccharides stimulate fibroblast activity, increase the synthesis of collagen and glycosaminoglycans, and promote epidermal hydration. At the cellular level, aloe modulates the NF-κB signaling pathway and reduces the expression of pro-inflammatory cytokines.

The ceramides included in the preparation are sphingolipids identical to the endogenous lipid components of the skin's stratum corneum. Their pharmacodynamic role is to restore the barrier function, reduce transepidermal water loss, and stabilize the microecological balance of the scalp.

Systemic targets of the preparation are minimal due to topical application; however, a wide range of local effects are realized: antimicrobial (inhibition of bacterial and fungal colonization), anti-inflammatory (reduction in the activity of inflammatory mediators), antioxidant (reduction of oxidative stress at the level of keratinocytes), and barrier-protective (restoration of the scalp's lipid layer). These effects are tissue-specific, manifesting primarily in the scalp and hair structures.

The pharmacodynamics of the preparation demonstrate a complex action combining direct inhibition of pathogenic microorganisms, modulation of inflammatory and oxidative cascades, stimulation of reparative processes, and stabilization of the epidermal barrier.

References: PubMed PMID: 28654606; PubMed PMID: 27481154; PMC6227514; ScienceDirect doi:10.1016/j.phymed.2012.10.020; Wiley Online Library doi:10.1002/ptr.6100.

Pharmacokinetics of Organic Aloe Vera & Tea Tree Shampoo

When applied topically, the shampoo's active substances interact primarily with the epidermal barrier and skin appendages. The terpenoids from Melaleuca alternifolia essential oil possess lipophilicity, which enables partial transdermal absorption through the stratum corneum and hair follicle orifices. Distribution occurs within the epidermis and upper dermis, followed by binding to the lipid structures of cell membranes. The metabolism of these compounds is mediated by local enzymatic systems in the skin (oxidoreductases, esterases). Residual amounts that reach the systemic circulation undergo biotransformation in the liver, resulting in hydroxylated and conjugated metabolites that are primarily excreted in urine and bile.

The polysaccharides and phenolic compounds of Aloe vera, when applied topically, have limited absorption due to their high molecular weight and hydrophilicity. Their action is primarily local, occurring on the skin surface and within the epidermal layers. Systemic absorption is minimal, and metabolism and elimination do not play a significant role.

Ceramides, being structural lipids of the stratum corneum, do not penetrate deeply into the systemic bloodstream but instead integrate into the epidermal lipid matrix. Their metabolism is carried out by local ceramidase and sphingomyelinase systems in the skin, with catabolites being eliminated naturally through epithelial renewal.

Thus, the pharmacokinetics of the preparation are characterized by a predominantly local action with minimal systemic exposure. Terpenoids are partially metabolized by the liver in cases of accidental absorption, while polysaccharides and ceramides exert local effects without significant systemic distribution.

References: https://pubmed.ncbi.nlm.nih.go... https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/...

Mechanisms of Action and Scientific Rationale: Organic Aloe Vera & Tea Tree Shampoo

Liver and Gastrointestinal Tract. Given minimal systemic absorption, the active compounds of tea tree oil, primarily terpenoids, undergo metabolism in the liver involving cytochrome P450 monooxygenase systems. Their effect on hepatic enzymes is associated with antioxidant and membrane-stabilizing properties, realized through a reduction in lipid peroxidation. Aloe vera polysaccharides can modulate the gut microbiota and suppress the growth of opportunistic strains, demonstrating an additive interaction with lipophilic terpenes.
Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. The terpenoids from Melaleuca alternifolia and the polysaccharides from Aloe vera act on innate immunity cascades. They suppress the activation of NF-κB and MAPK signaling pathways, reducing the expression of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6). The nature of the interaction is potentiating: terpenoids reduce microbial stimulation, while polysaccharides additionally regulate the activity of macrophages and neutrophils. This ensures a tissue-specific reduction in inflammatory reactions at the skin level.
Reference: https://pmc.ncbi.nlm.nih.gov/a...

Nervous System. With topical application, terpenoids have a modulating effect on sensory endings, reducing the transmission of pain and itching impulses. Studies indicate interaction with TRPV1 receptors and an mediated reduction in the release of substance P. Aloe vera extract exerts a sedative effect on peripheral nerve endings through skin hydration and the reduction of local irritation. These effects are additive in nature, are realized at the tissue level, and lack systemic impact.
Reference: https://pubmed.ncbi.nlm.nih.go...

Endocrine and Metabolic Regulation. Data on direct effects on endocrine organs are limited; however, the antioxidant properties of the components influence the regulation of redox status, which is significant for metabolic processes. Aloe polysaccharides exhibit a modulating effect on protein glycosylation and the regulation of energy metabolism in epithelial cells. The combined presence of lipophilic and hydrophilic compounds demonstrates a protective type of interaction, preventing oxidative damage to lipid and protein structures.
Reference: https://link.springer.com/arti...

Skin and Appendages. This is the primary site of action for the preparation. Tea tree oil disrupts the integrity of microbial cell membranes and inhibits enzymatic systems (including lipoxygenase), reducing the synthesis of pro-inflammatory mediators. Aloe extract potentiates these effects by stabilizing the activity of antioxidant enzymes (superoxide dismutase, catalase) and accelerating the regeneration of epithelial cells. Ceramides replenish the lipid barrier deficit, which modulates the absorption of other components and reduces local irritation. The combined action is characterized by a potentiating and protective nature, realized at the tissue and cellular levels. 
Reference: https://pmc.ncbi.nlm.nih.gov/a...