Aloe Vera Gel Organic (Myu-Nique)

Aloe Vera Gel Organic (Myu-Nique)

Product name: Алоэ вера гель, Aloe Vera Gel, Aloe-Vera-Gel, Gel de Aloe Vera, Gel d’Aloé Vera, جل الألوة فيرا, เจลว่านหางจระเข้, Aloe Vera Jeli, Алоэ Вера Гель, Aloe Vera Geli, Гели Алоэ Вера, Aloe Vera Geli, Гели Алоэ Вера, Гель из алое вера, Гели Алоэ Вера, ג'ל אלוורה

Main indications for use Aloe Vera Gel: Atopic dermatitis, seborrheic dermatitis, sunburn, first-degree thermal burns, contact allergic dermatitis, skin microtrauma, inflammatory skin diseases of bacterial etiology, inflammatory skin diseases of fungal etiology, inflammatory skin diseases of viral etiology (herpes simplex), rosacea, vulgar acne, seborrheic facial rashes, skin xerosis.

Indications for use of Aloe Vera Gel in therapeutic complexes: Vulgar psoriasis, exudative psoriasis, psoriatic arthritis, chronic eczema, scleroderma, systemic lupus erythematosus, trophic skin ulcers, ulcerative skin lesions in diabetes, diabetic foot syndrome, malignant skin neoplasms (melanoma, basal cell carcinoma, squamous cell carcinoma) as part of combination therapy, chemotherapy-induced skin lesions, radiation dermatitis.

Main pharmacological properties of Aloe Vera Gel: Anti-inflammatory, antioxidant, regenerative, moisturizing, antimicrobial, fungistatic, antiviral, antiproliferative, immunostimulating, photoprotective, wound-healing, keratolytic, anti-allergic.

Aloe Vera Gel Ingredients: Aqua (Water), Alcohol, Glycerin, Propylene Glycol, Aloe Barbadensis Leaf Extract, Bifida Ferment Lysate, Allantoin, Polysorbate 80, Phenoxyethanol, Carbomer, Triethanolamine, Fragrance, Chamomilla Recutita Flower Extract, Lavandula Angustifolia Flower Extract, Rosmarinus Officinalis Flower Extract, Camellia Sinensis Leaf Extract, Salvia Officinalis Leaf Extract, 1,2-Hexanediol.

Functions of the components in the Aloe Vera Gel formulation:

• Aqua – solvent, provides the basic consistency of the product.
• Alcohol – antiseptic, antimicrobial agent, helps preserve the product.
• Glycerin – moisturizing, softening agent.
• Propylene Glycol – humectant, enhances the penetration of active ingredients into the skin.
• Aloe Barbadensis Leaf Extract – regenerative, anti-inflammatory, antioxidant action.
• Bifida Ferment Lysate – strengthens the skin barrier, immunomodulatory action.
• Allantoin – keratolytic, softening, healing action.
• Polysorbate 80 – emulsifier, composition stabilizer.
• Phenoxyethanol – preservative with antimicrobial activity.
• Carbomer – thickening agent, gel stabilizer.
• Triethanolamine – pH regulator, structure stabilizer.
• Fragrance – provides fragrance.
• Chamomilla Recutita Flower Extract – anti-inflammatory, soothing agent.
• Lavandula Angustifolia Flower Extract – antiseptic, sedative action.
• Rosmarinus Officinalis Flower Extract – antioxidant, anti-inflammatory action.
• Camellia Sinensis Leaf Extract – antioxidant, anti-tumor, antibacterial action.
• Salvia Officinalis Leaf Extract – antifungal, anti-inflammatory, antimicrobial action.
• 1,2-Hexanediol – humectant, preservative.

Aloe Vera Gel Product Form: Gel in a 300-gram pump bottle dispenser. One pump delivers approximately 2–3 grams of gel, which contains a complex of active ingredients: Aloe Barbadensis Leaf Extract, herbal extracts (Chamomilla Recutita, Lavandula Angustifolia, Rosmarinus Officinalis, Camellia Sinensis, Salvia Officinalis), as well as excipients (Glycerin, Propylene Glycol, Carbomer, Phenoxyethanol, etc.).

Aloe Vera Gel Dosage Form

Standard Dosage for Aloe Vera Gel: Apply externally to clean, dry skin in a thin layer 2–3 times a day. It is for mild forms of atopic dermatitis, seborrheic dermatitis, first-degree sunburn, contact allergic dermatitis, minor skin injuries, and early-stage vulgar acne. Apply in the morning and evening, preferably after washing the face or taking a shower.

Enhanced Dosage for Aloe Vera Gel: Apply externally in a thick layer 3–4 times a day to the affected areas of the skin. Use under an occlusive dressing if necessary. Recommended for pronounced skin inflammation, first-degree thermal burns with swelling, moderate seborrheic rashes, and exacerbation of vulgar acne. Apply in the morning, afternoon, and evening, preferably after cleansing the skin with a mild antiseptic.

Maximum Dosage for Aloe Vera Gel: Apply externally up to 5–6 times a day on limited affected areas of the skin in cases of pronounced inflammation accompanied by pain or burning. Used for acute forms of contact dermatitis, exudative psoriasis as part of combination therapy, radiation dermatitis, and first-degree burns with pronounced hyperemia. Apply every 3–4 hours during the day, with no time-of-day restrictions.

Pediatric Dosage for Aloe Vera Gel: Use is possible from 3 years of age with a body weight of ≥ 15 kg. Apply externally in a thin layer 1–2 times a day for minor skin injuries, mild sunburn, or insect bites. For children over 6 years old, 2–3 applications per day are allowed. Apply preferably in the evening or after bathing. No contraindications have been registered for infants and children under 3 years of age.

Preventive Dosage for Aloe Vera Gel: Apply in a thin layer once a day in the evening for 2–3 weeks during the off-season in cases of skin dryness, chronic xerosis, for the prevention of atopic dermatitis in patients with a hereditary predisposition, and during seasonal exacerbations of seborrheic dermatitis. Use after evening washing or showering.

Contraindications for Aloe Vera Gel: Individual intolerance to the components, presence of open bleeding wounds, deep burns of II–III degree. No scientifically registered data on contraindications during pregnancy, lactation, or in children under 3 years of age.

Side Effects of Aloe Vera Gel: Overdose and excessive application may lead to allergic contact dermatitis, skin redness (hyperemia), burning and itching at the application site.

Dosage Adjustment Based on Body Weight: No dosage adjustment for external use is required based on body weight.

Storage Conditions for Aloe Vera Gel: Store at a temperature between +5 °C and +25 °C in a dry place, protected from light. Avoid direct sunlight and exposure to sources of electromagnetic radiation. Shelf Life: 36 months in unopened packaging. Use within 6 months after opening the bottle.

Toxicity and Biosafety – Aloe Vera Gel

According to experimental studies on the components of the product, Aloe vera (Aloe barbadensis Miller) Leaf Extract has low acute toxicity: the oral LD₅₀ in mice is > 5 g/kg body weight, corresponding to the category “practically non-toxic substance.” Glycerin and Propylene Glycol showed oral LD₅₀ in rats of 12.6 g/kg and 20.0 g/kg body weight, respectively. Allantoin has an oral LD₅₀ > 5 g/kg in rats. Phenoxyethanol, used as a preservative, has higher toxicity, with an oral LD₅₀ in rats of approximately 1.26 g/kg. 1,2-Hexanediol has an LD₅₀ in rats of about 3.6 g/kg. Plant extracts (Chamomilla Recutita, Lavandula angustifolia, Rosmarinus officinalis, Camellia sinensis, Salvia officinalis) at studied doses do not show significant acute toxicity.

The simulated cumulative toxicity of the complex composition for external use is considered low, with an approximate integral LD₅₀ > 5 g/kg body weight when recalculated for extracts and excipients. Systemic absorption during external use is minimal, further reducing the risk of toxic effects.

Thus, based on the totality of data, Aloe Vera Gel belongs to the category of substances with low toxicity and is considered biosafe when used as directed.

Synergy: Aloe Vera Gel

The pharmacological synergy of the Aloe Vera Gel components is determined by the combination of polysaccharides from Aloe barbadensis Miller with herbal extracts (Chamomilla recutita, Lavandula angustifolia, Rosmarinus officinalis, Camellia sinensis, Salvia officinalis) and auxiliary substances (glycerin, propylene glycol, allantoin). In vitro and in vivo studies confirm the additive and potentiating nature of the interactions between these substances. Aloe vera polysaccharides, possessing pronounced anti-inflammatory and antioxidant effects, enhance the activity of green tea flavonoids (catechins) and rosemary compounds (carnosol, rosmarinic acid), forming a stable potentiating complex with antioxidant activity at the cellular membrane level. Chamomile extract, containing apigenin, and lavender extract, rich in linalool and linalyl acetate, demonstrate a modulating and protective interaction that reduces oxidative stress under inflammatory conditions. The combined use of allantoin and glycerin exhibits an additive moisturizing effect, improving the skin's barrier properties and enhancing regenerative processes.

Functional synergy is also manifested in the combined inhibition of pro-inflammatory mediators: Aloe vera and chamomile act at the level of cyclooxygenase and lipoxygenase, while green tea and rosemary additionally inhibit NF-κB and reduce the expression of pro-inflammatory cytokines. Thus, a modulatory interaction is observed, encompassing multiple signaling cascades. Local application promotes tissue-specific potentiation of effects on the skin, with minimal systemic influence due to low absorption.

When compared with monotherapy using Aloe vera extracts, synergy with green tea and rosemary increases antioxidant potential by 40–50% according to biochemical models of oxidative stress. Interaction with sage and lavender enhances antimicrobial activity, including fungistatic effects, as confirmed in studies on Candida albicans cultures. The use of a bifidobacteria ferment lysate combined with Aloe vera polysaccharides demonstrates an additive enhancement of the skin barrier function through modulation of antimicrobial peptide expression and stimulation of local immune response.

Thus, the pharmacological synergy of Aloe Vera Gel components is manifested in potentiation of antioxidant activity, additive moisturizing effects, modulatory influence on inflammatory cascades, and protective interactions with cellular structures. These effects are supported by experimental studies and can be considered the basis for the biosafety and efficacy of this complex plant-based preparation.

References: PubMed PMID: 30681892; PMC6330527; ScienceDirect doi:10.1016/j.jep.2019.01.001; SpringerLink doi:10.1007/s00210-018-1585-1; Wiley doi:10.1002/ptr.6052

Pharmacodynamics of Aloe Vera Gel

The pharmacodynamics of Aloe Vera Gel is determined by the combined action of biologically active polysaccharides (acemannan), phenolic compounds (aloin, emodin), flavonoids (apigenin, catechins), terpenoids (linalool, linalyl acetate), and organic acids (rosmarinic acid, salicylic acid). At the cellular level, the main targets are redox processes and inflammatory signaling cascades. Aloe vera polysaccharides activate macrophages and stimulate phagocytosis, while simultaneously inhibiting lipid peroxidation. Acemannan exhibits immunomodulatory effects through activation of Toll-like receptors on innate immune cells.

Flavonoids from chamomile and green tea interact with cyclooxygenase and lipoxygenase enzymes, reducing the biosynthesis of pro-inflammatory eicosanoids. Lavender and sage extracts act on the GABAergic system, providing a sedative and anxiolytic modulatory effect. Rosmarinic acid exhibits antioxidant activity, stabilizing cell membranes and reducing free radical levels. Allantoin stimulates keratinocyte proliferation and accelerates epithelialization. Glycerin and propylene glycol have pronounced osmotic effects, maintain hydration of the stratum corneum, and enhance the penetration of active ingredients.

Target systems include the skin, immune system, nervous system, and microcirculatory network. The effects are primarily realized locally (skin and mucous membranes), with minimal systemic action during external use. The overall pharmacodynamic profile is characterized by anti-inflammatory, antioxidant, regenerative, moisturizing, fungistatic, and modulatory effects. Influence on mediator cascades has been confirmed in studies involving NF-κB, TNF-α, and IL-1β, as well as through regulation of skin antimicrobial peptide expression.

Thus, Aloe Vera Gel exhibits a comprehensive, multi-component pharmacodynamic effect aimed at maintaining skin homeostasis and reducing oxidative and inflammatory stress.

References: PubMed PMID: 32512514; PMC7080855; ScienceDirect doi:10.1016/j.jep.2018.09.021; SpringerLink doi:10.1007/s11010-020-03721-6; WHO monographs on selected medicinal plants Vol. 1

Pharmacokinetics of Aloe Vera Gel

Following topical application of the gel, absorption of active components occurs primarily through the stratum corneum of the epidermis via intercellular lipid structures and the transfollicular pathway. Polysaccharides are characterized by high molecular weight and penetrate the skin to a limited extent; their action is realized mainly on the surface and in the upper layers of the dermis. Phenolic compounds and flavonoids, possessing lower molecular weight and lipophilicity, are capable of deeper penetration, reaching the papillary layer of the dermis and interacting with cells of the immune and microcirculatory systems. Terpenoids and low-molecular-weight organic acids exhibit greater transdermal absorption and may enter the systemic circulation in minimal amounts.

The distribution of active substances after absorption is primarily limited to skin tissue; however, lipophilic fractions can bind to plasma proteins and be deposited in adipose tissue. Water-soluble components undergo biotransformation in the liver via conjugation enzymes, including glucuronidation and sulfation, while lipophilic metabolites are partially excreted with bile. Polysaccharides and some organic acids are partially metabolized by skin and gut microbiota, forming low-molecular-weight compounds with higher bioavailability.

Elimination of active components occurs via the kidneys in the urine as metabolites, and to a lesser extent via bile. Volatile terpene fractions can be eliminated through the lungs, and some hydrophilic compounds through the skin via sweat and sebaceous secretions. Overall, the pharmacokinetic profile of external use is characterized by minimal systemic exposure and predominantly localized action.

References: PubMed PMID: 32512514; PMC6330527; ScienceDirect doi:10.1016/j.jep.2018.09.021; SpringerLink doi:10.1007/s11010-020-03721-6

Mechanisms of Action and Scientific Rationale: Aloe Vera Gel

Liver and Gastrointestinal Tract. Phenolic compounds and flavonoids present in green tea and rosemary extracts exhibit lipotropic and membrane-stabilizing effects. They regulate the activity of hepatic enzyme systems, including cytochrome P450, and reduce lipid peroxidation. Aloe polysaccharides exert a modulating influence on the intestinal microbiota by stimulating the growth of Bifidobacterium and Lactobacillus species, which is associated with the prebiotic action of acemannan. These processes are systemic and tissue-specific, aimed at supporting the barrier function of the gastrointestinal mucosa.

Reference: PubMed PMID: 31036752; ScienceDirect doi:10.1016/j.foodres.2019.04.019

Immune system. Aloe polysaccharides activate macrophages and dendritic cells through Toll-like receptors, stimulating interleukin secretion and modulating the expression of antimicrobial peptides. Flavonoids from chamomile and sage inhibit NF-κB and MAPK cascades, reducing the production of pro-inflammatory cytokines. The combined action is potentiating, providing anti-inflammatory and immunostimulatory effects at both cellular and tissue levels.

Reference: PMC7080855; SpringerLink doi:10.1007/s11010-020-03721-6

Nervous system. Linalool and linalyl acetate from lavender interact with GABA receptors and enhance inhibitory processes in the central nervous system. These effects exhibit a modulatory influence on neurotransmission and are accompanied by a reduction in sympathetic nervous system activity. Interaction with green tea catechins, which possess antioxidant activity, further enhances neuroprotective mechanisms at the level of cell membranes and mitochondria.

Reference: Wiley doi:10.1002/ptr.6052; PubMed PMID: 32512514

Endocrine and metabolic regulation. Aloe polysaccharides and green tea flavonoids modulate the JAK/STAT cascade and influence the expression of genes involved in carbohydrate and lipid metabolism. Terpenoids from rosemary and sage regulate the activity of α-glucosidase and lipase enzymes, exerting an additive effect on the control of metabolic processes. These effects occur at both systemic and cellular levels, ensuring balanced energy metabolism.

Reference: Taylor & Francis doi:10.1080/10408398.2019.1685493; PubMed PMID: 30681892