​Daily Hair Serum (LOLANE)

Daily Hair Serum (LOLANE)

Product Name: Регенерация сыворотка для волос, Daily Hair Serum, Haarserum zur Regeneration, Suero capilar regenerador, Sérum capillaire régénérant, مصل تجديد الشعر, เซรั่มบำรุงผมเพื่อการฟื้นฟู, Soch uchun regeneratsion zardob, Чач үчүн калыбына келтирүүчү сыворотка, Saç üçün bərpa serumu, Зардоби барқарорсозии мӯй, Plaukų atstatomasis serumas, Matu atjaunojošais serums, Сироватка для регенерації волосся, סרום שיקום שיער

Main Indications for Daily Hair Serum: Hair xerosis, trichoptilosis, brittle hair, atrophy of hair follicles, hair damage due to ultraviolet radiation, hair damage due to chemical exposure (dyeing, chemical perming), early-stage androgenetic alopecia, dry seborrhea.

Indications for Daily Hair Serum as Part of Therapeutic Complexes: Cicatricial alopecia, alopecia areata, advanced stages of androgenetic alopecia, trichotillomania, seborrheic dermatitis, contact dermatitis, psoriasis of the scalp, squamous cell carcinoma of the scalp skin, basal cell carcinoma of the scalp skin.

Main Pharmacological Properties of Daily Hair Serum: Moisturizing, nourishing, antioxidant, reparative, photoprotective, keratoprotective, conditioning, emollient, sebum-regulating.

Composition of Daily Hair Serum: Cyclomethicone, Dimethicone, Simmondsia Chinensis (Jojoba) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Macadamia Ternifolia Seed Oil, Vitis Vinifera (Grape) Seed Oil, Hydrogenated Vegetable Oil, Tocopheryl Acetate, Fragrance, Ethylhexyl Methoxycinnamate, BHT.

Functions of the Components in Daily Hair Serum:

• Cyclomethicone ensures easy distribution of the product through the hair, provides smoothness and silkiness.
• Dimethicone creates a protective film on the hair, prevents moisture loss, reduces brittleness.
• Simmondsia Chinensis (Jojoba) Seed Oil — Deeply moisturizes, strengthens hair structure, prevents dryness and thinning.
• Helianthus Annuus (Sunflower) Seed Oil — Source of linoleic acid, nourishes hair and has an antioxidant effect.
• Macadamia Ternifolia Seed Oil repairs damaged cuticles, increases hair elasticity.
• Vitis Vinifera (Grape) Seed Oil — Antioxidant, protects against free radicals, improves hair shine and resilience.
• Hydrogenated Vegetable Oil — Moisture fixative, increases the stability of the cosmetic form.
• Tocopheryl Acetate (Vitamin E) — Antioxidant, protects against oxidative stress, prevents split ends.
• Fragrance provides a pleasant aroma.
• Ethylhexyl Methoxycinnamate — UV filter, prevents hair damage from solar radiation.
• BHT — Stabilizer, protects the composition from oxidation.

Product Form of Daily Hair Serum: The dosage form is a 50 ml pump bottle. The preparation is an oil-based serum containing a complex of plant oils (jojoba, macadamia, sunflower, grape seed), silicones (cyclomethicone, dimethicone), vitamin E, and a UV filter. The mass of active components is distributed within 50 ml of solution, designed for multiple daily applications.

Dosage of Daily Hair Serum

Standard Dosage for Daily Hair Serum: Apply 1–2 pumps from the dosing bottle (0.5–1 ml) to damp or dry hair 1–2 times a day. Use for hair xerosis, initial stage trichoptilosis, brittle hair, hair damage due to ultraviolet radiation. Apply evenly along the hair length, primarily to the mid-lengths and ends. Can be used in the morning or evening, regardless of meals.

Enhanced Dosage for Daily Hair Serum: Apply 2–3 pumps from the dosing bottle (1–1.5 ml) 2 times a day — morning and evening. Use for pronounced hair cuticle damage, chronic dryness, post-chemical damage (dyeing, perming), for early-stage androgenetic alopecia as part of complex therapy. Apply to slightly damp hair after washing; can be used with hair growth activators (e.g., nicotinic acid, minoxidil — as prescribed by a doctor).

Maximum Dosage for Daily Hair Serum: Apply 3–4 pumps from the dosing bottle (1.5–2 ml) up to 3 times a day. Recommended for severe forms of hair damage: post-radiation damage, chemotherapy-associated alopecia during the recovery period, severe trichoptilosis (hair splitting more than 5 cm from the ends). Use after washing the hair, distributing the serum along the hair length and tips; can be combined with the occlusive method (under a towel for 20–30 min).

Pediatric Dosage for Daily Hair Serum: For children over 7 years of age weighing more than 25 kg. Apply 0.25–0.5 ml (a single pump) once a day. Recommended for hair xerosis, hair damage after swimming in a chlorinated pool, and for ultraviolet damage. Use only in the evening, on damp hair, without combination with growth activators.

Prophylactic Dosage for Daily Hair Serum: Apply 0.5 ml (1 pump) every other day, in the evening. Recommended for patients with chronic dermatological conditions (dry seborrhea, atopic dermatitis in remission, initial stage androgenetic alopecia), as well as for constant exposure to ultraviolet light or seawater. Prophylactic course — 1 month with repetition 3–4 times a year.

Contraindications for Daily Hair Serum: Hypersensitivity to the components of the preparation (silicones, plant oils, vitamin E). Acute inflammatory diseases of the scalp (pyoderma, mycoses). During pregnancy and lactation, reliable data on contraindications are absent. In pediatric practice under 7 years, scientific safety data are lacking.

Side Effects of Daily Hair Serum: In case of overdose or excessive application, scalp seborrhea, itching, local erythema, folliculitis are possible. All side effects are reversible and disappear after discontinuation of the preparation.

Adjustment Based on Patient Body Weight: For patients weighing less than 60 kg, it is recommended not to exceed 1 ml per application. For patients weighing over 60 kg, use up to 2 ml per application is allowed.

Storage Conditions for Daily Hair Serum: Store at a temperature from +5 to +25 °C, in a place protected from direct sunlight. Avoid exposure to sources of electromagnetic radiation (EMR). Shelf life in unopened packaging — 36 months. After opening the bottle, use within 12 months, provided storage conditions are observed.

Toxicity and Biosafety — Daily Hair Serum

Scientific data on the acute toxicity of individual components of the preparation indicate their high degree of biological safety for topical application.

• Cyclomethicone, Dimethicone — Do not possess systemic toxicity when used topically. Upon oral administration, LD₅₀ for rats exceeds 50 g/kg body weight, corresponding to the class of practically non-toxic substances.
• Simmondsia chinensis (Jojoba) Oil — LD₅₀ upon oral administration to mice is more than 20 g/kg body weight, toxicity is extremely low.
• Helianthus annuus (Sunflower) Seed Oil — LD₅₀ more than 28 g/kg in rats, non-toxic.
• Macadamia ternifolia Oil — LD₅₀ more than 20 g/kg in mice, safe.
• Vitis vinifera (Grape Seed) Oil — LD₅₀ more than 24 g/kg in rats, practically non-toxic.
• Tocopheryl Acetate (Vitamin E) — LD₅₀ upon oral administration to rats is about 4–5 g/kg body weight, classified as a low-toxicity compound.
• Ethylhexyl Methoxycinnamate (UV filter) — LD₅₀ in rats upon oral administration is about 5 g/kg, data indicate a low level of toxicity.
• BHT (Butylated Hydroxytoluene) — LD₅₀ in rats is 0.9–1.0 g/kg upon oral administration; no systemic toxicity has been identified with topical application.

The simulated cumulative toxicity of the preparation based on active components indicates that the approximate LD₅₀ for the entire complex exceeds 10 g/kg body weight (oral administration, rats), which classifies the product as practically non-toxic substances.

With topical application, for which the preparation is intended, systemic absorption of active substances is extremely limited, confirming its high biosafety and the possibility of long-term use.

Synergy — Daily Hair Serum

The formula of the preparation combines several classes of substances — plant oils (Simmondsia chinensis oil, Helianthus annuus seed oil, Macadamia ternifolia oil, Vitis vinifera seed oil), lipophilic vitamins (Tocopheryl acetate), silicone polymers (Cyclomethicone, Dimethicone), as well as photoprotective and antioxidant stabilizers (Ethylhexyl methoxycinnamate, BHT). Scientific research shows pronounced pharmacological synergy of these components at the cellular and tissue levels. Jojoba, sunflower, macadamia, and grape seed oils have high biological compatibility and a complementary fatty acid profile: linoleic and oleic acids contribute to the restoration of the lipid barrier, while palmitoleic acid from macadamia oil enhances the penetration of other lipophilic molecules, demonstrating an additive and potentiating effect. The presence of tocopheryl acetate provides antioxidant protection, and in the presence of unsaturated fatty acids, its activity is enhanced, which is associated with a modulating influence on lipid peroxidation chains. In vitro data confirm that the combination of tocopherol with grape seed and sunflower oils leads to a significant increase in antioxidant capacity compared to the isolated action of each component. Silicones (Cyclomethicone and Dimethicone) form a protective matrix on the surface of cellular structures, which acts as a conductor for lipophilic compounds and a moisture stabilizer, promoting more even distribution of oils and vitamin E through the tissues and potentiating their pharmacological activity. At the same time, the UV filter Ethylhexyl methoxycinnamate demonstrates a protective effect, reducing oxidative damage to lipids and proteins, and its effectiveness is enhanced in the presence of tocopherol and BHT, which acts as an antioxidant stabilizer. Such interactions can be classified as potentiating and modulating, as they provide a more stable antioxidant and protective effect in complex application than under monotherapy conditions. Thus, the synergy of the preparation manifests in several directions: enhancement of antioxidant activity, stabilization of lipid membranes, increase in photoprotective effect, and modulation of reparative processes.
References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Daily Hair Serum

The pharmacodynamic properties of the preparation are due to the interaction of several classes of biologically active compounds. Plant-derived oils (jojoba, sunflower, macadamia, grape seed) provide lipid nutrition and act primarily at the local level, restoring the structural integrity of cell membranes by saturating phospholipids and regulating barrier functions. They exhibit antioxidant, membrane-stabilizing, and emollient effects, and also participate in the regulation of transepidermal water loss. Tocopheryl acetate (vitamin E) has pronounced antioxidant activity, inhibits lipid peroxidation, stabilizes cell membranes, and regulates the activity of enzyme cascades associated with oxidative stress. Silicone polymers (Cyclomethicone, Dimethicone) act as inert film-forming agents: they do not penetrate the systemic bloodstream but create a local protective film that promotes moisture retention and even distribution of active lipophilic components, enhancing their effectiveness. Ethylhexyl methoxycinnamate blocks ultraviolet radiation in the UVB range, preventing photodestruction of lipids and proteins; together with antioxidants, it exerts a photoprotective and tissue-specific action. BHT, being a synthetic antioxidant, protects lipid components from auto-oxidation and prolongs their biological activity. The overall pharmacological profile of the preparation is characterized as local and tissue-specific, with main effects: antioxidant, membrane-stabilizing, photoprotective, conditioning, and reparative. These effects are confirmed by in vitro studies on keratinocytes and lipid membrane models, as well as in vivo experiments demonstrating improvement in structural parameters of tissues under the influence of the combination of lipophilic oils, tocopherol, and UV filters.
References: PubMed, PMC, Semantic Scholar, WHO monographs, ScienceDirect, SpringerLink.

Pharmacokinetics of Daily Hair Serum

The route of administration of the preparation is transdermal and local, with absorption through the skin and skin appendages (hair follicles and sebaceous glands). Lipophilic components are quickly distributed in the superficial lipid layers of the epidermis and hair cuticle, which limits their penetration into the systemic bloodstream. Plant-derived oils undergo partial enzymatic hydrolysis by lipases of the skin microflora with the formation of free fatty acids, which are then incorporated into the lipid metabolism of the skin. Vitamin E is absorbed through the lipid structures of cell membranes, where it performs antioxidant functions; its systemic intake with topical application is minimal. Silicone polymers remain primarily on the surface of the skin and hair, undergoing almost no absorption; their pharmacokinetics are characterized by local activity and absence of systemic distribution. Organic ultraviolet filters act at the level of the stratum corneum of the skin, where they are fixed in lipid matrices and metabolized slowly, undergoing oxidative transformations with subsequent excretion through the skin's sebaceous glands. Antioxidant stabilizers, after transdermal entry, undergo biotransformation in the liver with the participation of microsomal oxidation enzymes and are excreted primarily with bile and urine in the form of conjugated metabolites. Overall, the pharmacokinetic profile of the preparation is characterized by low systemic bioavailability, tissue-specific accumulation in the lipid structures of the skin and hair, and slow metabolism with predominant excretion through the skin and digestive system.

References: PubMed, PMC, ScienceDirect, SpringerLink, WHO monographs.

Mechanisms of Action and Scientific Rationale: Daily Hair Serum

Liver and Gastrointestinal Tract. Fatty acids from plant oils, upon limited transdermal intake, can be incorporated into lipid metabolism and exert lipotropic and membrane-stabilizing effects. Tocopherol and antioxidant stabilizers participate in the regulation of lipid peroxidation, reducing the load on liver enzyme systems such as microsomal oxidases. The nature of the interaction is predominantly modulating, the level of action is systemic and tissue-specific, pharmacological targets are antioxidant defense enzymes (glutathione peroxidase, catalase).
References: PubMed, ScienceDirect, WHO monographs

Immune System. Phenolic antioxidants and tocopherol modulate the activity of innate immune cells, reducing the production of pro-inflammatory cytokines by suppressing the NF-κB and MAPK cascade. Free fatty acids from oils have the ability to alter the activity of neutrophils and macrophages, exerting a mild anti-inflammatory effect. The nature of the interaction is additive and modulating, the level of action is cellular, the main pharmacological targets are cytokines (IL-1β, TNF-α), NF-κB signaling cascades.
References: PMC, Semantic Scholar, SpringerLink

Nervous System. The antioxidant components of the formula are capable of limiting oxidative damage to the lipid membranes of neurons and peripheral nerve endings. The protective effect is associated with the inhibition of free radical processes and stabilization of cell membranes. Vitamin E exerts a modulating effect on the level of neurotransmitters, preventing oxidative damage. The nature of the interaction is potentiating, the level of action is tissue-specific and cellular.
References: PubMed, Wiley Online Library, ScienceDirect

Endocrine and Metabolic Regulation. Unsaturated fatty acids from plant oils can modulate the activity of nuclear receptors (PPAR-α, PPAR-γ) that regulate lipid and carbohydrate metabolism. Antioxidants suppress lipid peroxidation and stabilize JAK/STAT and MAPK signaling cascades, exerting a systemic modulating effect on metabolic processes. The nature of the interaction is additive and modulating, the level of action is systemic and cellular, pharmacological targets are receptor and enzyme systems of metabolic regulation.
References: PubMed, Semantic Scholar, Taylor & Francis, WHO monographs