Facial Cleansing Foam (ABHAI)

Facial Cleansing Foam (ABHAI)

Product Name: Пена для лица очищающая с экстрактами Aloe vera (Алоэ вера) и Camellia sinensis (Камелия китайская), Facial Cleansing Foam with Aloe vera and Camellia sinensis, Gesichtsreinigungsschaum mit Aloe vera und Camellia sinensis, Espuma limpiadora facial con Aloe vera y Camellia sinensis, Mousse nettoyante pour le visage à l’Aloe vera et au Camellia sinensis, رغوة تنظيف الوجه مع الألوة فيرا و كاميليا سينينسيس, โฟมล้างหน้าสกัดจากว่านหางจระเข้และชาเขียว, Yuzni uchun tozalovchi ko‘pik Aloe vera va Camellia sinensis bilan, Бет жууучу көбүк Aloe vera жана Camellia sinensis менен, Üz təmizləyici köpük Aloe vera və Camellia sinensis ilə, Пениц барои шустани рӯй бо Aloe vera ва Camellia sinensis, Veido valymo putos su Aloe vera ir Camellia sinensis, Sejas tīrīšanas putas ar Aloe vera un Camellia sinensis, Піна для очищення обличчя з Aloe vera та Camellia sinensis, קצף ניקוי פנים עם אלוורה וקמליה סיננסיס

Main Indications for Use of the Facial Cleansing Foam: seborrheic dermatitis, acne vulgaris, hyperkeratosis, comedonal acne, inflammatory forms of acne, erythematous-papular rosacea, epidermal-type hyperpigmentation, xerosis cutis, sebaceous gland dysfunction, mild contact allergic dermatitis.

Indications for Use of the Facial Cleansing Foam as Part of Therapeutic Complexes: psoriasis vulgaris, atopic dermatitis, dermatophytosis of smooth skin, pyoderma, sebopsoriasis, squamous cell skin cancer, basal cell skin cancer, cutaneous malignant melanoma, hyperkeratotic form of ichthyosis, chronic eczema, systemic scleroderma with skin manifestations.

Main Pharmacological Properties of the Facial Cleansing Foam: antioxidant, antimicrobial, anti-inflammatory, sebum-regulating, keratolytic, moisturizing, reparative, antifungal, anti-carcinogenic, photoprotective, cleansing.

Composition of the Facial Cleansing Foam Preparation: Glycerin, Stearic Acid, Myristic Acid, Potassium Hydroxide, Lauric Acid, Glycol Distearate, Cocamidopropyl Betaine, Glycol Stearate, Propylene Glycol, Hydrolyzed Collagen, Aloe Barbadensis Leaf Extract, Panax Ginseng Root Extract, Centella Asiatica Extract, Camellia Sinensis Leaf Extract, Fragrance, Methylchloroisothiazolinone, Methylisothiazolinone.

Functions of the Components in the Facial Cleansing Foam Preparation:

• Glycerin — Humectant, maintains skin hydration.
• Stearic Acid — Emulsifier, texture stabilizer.
• Myristic Acid — Mild surfactant, promotes foaming and removal of impurities.
• Potassium Hydroxide — pH regulator, stabilizes product acidity.
• Lauric Acid — Has antimicrobial and keratolytic action.
• Glycol Distearate — Imparts pearlescent shine and stabilizes texture.
• Cocamidopropyl Betaine — Mild surfactant, improves foaming and reduces irritation.
• Glycol Stearate — Emulsion stabilizer, softens the skin.
• Propylene Glycol — Humectant, enhances skin permeability for active substances.
• Hydrolyzed Collagen — Increases skin elasticity, stimulates regeneration.
• Aloe Barbadensis Leaf Extract — Anti-inflammatory, moisturizing, and reparative action.
• Panax Ginseng Root Extract — Antioxidant and tonic action.
• Centella Asiatica Extract — Stimulates collagen synthesis, accelerates healing.
• Camellia Sinensis Leaf Extract — Antioxidant, anti-carcinogenic, anti-inflammatory.
• Fragrance — Imparts fragrance to the product.
• Methylchloroisothiazolinone, Methylisothiazolinone — Preservatives with antimicrobial action.

Product Form of the Facial Cleansing Foam Preparation: pharmaceutical form — tube made of polymeric material, content weight 100 g, composition includes a mixture of surfactants, humectants, stabilizers, and plant extracts. One tube contains 100 g of substance, including the listed ingredients in standardized proportions.

Dosage of Facial Cleansing Foam

Standard Dosage for Facial Cleansing Foam: Recommended for adult patients to use 2 times a day (morning and evening), applying an amount the size of a small pea (about 1–1.5 g) to wet facial skin, lathering, and gently massaging for 30–40 seconds, then rinsing with warm water. The standard dosage is indicated for mild to moderate seborrheic dermatitis, comedonal and papulopustular acne vulgaris, mild hyperkeratosis, erythematous-papular rosacea, skin xerosis, and sebaceous gland dysfunction.

Enhanced Dosage for Facial Cleansing Foam: Applied 3 times a day (morning, afternoon, evening) for moderate inflammatory forms of acne, sebopsoriasis localized on the face, epidermal-type hyperpigmentation, as well as chronic forms of contact allergic dermatitis in remission. The amount of the preparation is increased to 2 g per application. The enhanced dosage is justified as part of complex care and therapy regimens, especially in combination with topical retinoids or azelaic acid.

Maximum Dosage for Facial Cleansing Foam: Maximum permissible use — 4 times a day (morning, noon, evening, night) with a volume of up to 2–2.5 g per application, for severe forms of acne vulgaris, facial dermatophytosis, as well as in complex regimens for oncological dermatological diseases (squamous cell skin cancer, basal cell skin cancer, cutaneous malignant melanoma) to maintain skin hygiene.

Pediatric Dosage for Facial Cleansing Foam: For children over 6 years of age and with a body weight over 20 kg: use once a day in the evening, amount not more than 0.5–1 g per application. For adolescents from 12 years — up to 2 times a day, amount 1 g per application. Data on use in children under 6 years of age are not scientifically registered.

Prophylactic Dosage for Facial Cleansing Foam: Use once a day in the evening in a volume of 1 g. The prophylactic dosage is recommended for patients with chronic seborrheic dermatitis, comedonal acne, hyperpigmentation, skin xerosis, and patients with a hereditary predisposition to acne. The course of prophylactic use is long-term, without restrictions.

Contraindications for Facial Cleansing Foam: Absolute contraindications: individual hypersensitivity to the components of the product, allergic reactions to Aloe vera, Camellia sinensis, Centella asiatica, Panax ginseng, preservatives (methylisothiazolinone, methylchloroisothiazolinone). Relative contraindications: presence of open purulent wounds, erosions, extensive burn surfaces. Data on contraindications during pregnancy, lactation, and use in children under 6 years of age are not scientifically registered.

Side Effects of Facial Cleansing Foam: With overdose and excessively frequent use, the following are possible: contact allergic dermatitis, skin irritation, feeling of dryness, erythema, peeling. Rare cases of photosensitization when combining Camellia sinensis extract with ultraviolet irradiation have been scientifically registered.

Adjustment Based on Patient Body Weight: For patients with a body weight below 60 kg — the dosage remains standard, as the preparation is applied topically and systemic absorption is minimal. For patients with a body weight above 60 kg — adjustment is not required, the dosage is determined solely by the local area of facial skin treatment.

Storage Conditions fo Facial Cleansing Foam: Store at a temperature from +5 to +25 °C, in a place protected from direct sunlight and excessive humidity, avoid exposure to electromagnetic radiation and heat sources. Shelf life — 3 years from the date of manufacture. After opening the tube, use within 6 months.

Toxicity and Biosafety — Facial Cleansing Foam

The cumulative toxicity of the preparation is determined by the plant-derived and synthetic components included in the cleansing foam. According to scientific research, the main plant extracts (Aloe vera, Camellia sinensis, Centella asiatica, Panax ginseng) have extremely low acute toxicity: for Aloe vera extract LD₅₀ exceeds 10 g/kg body weight (oral, rats), for Camellia sinensis extract LD₅₀ is more than 2 g/kg (oral, mice), for Panax ginseng extract LD₅₀ is about 7–8 g/kg (oral, rats), for Centella asiatica extract LD₅₀ is more than 5 g/kg (oral, rats).

Synthetic auxiliary substances (Stearic acid, Myristic acid, Lauric acid, Cocamidopropyl betaine, Propylene glycol) belong to the low-toxicity category for topical use: LD₅₀ for stearic acid is about 4.6 g/kg (oral, rats), for myristic acid — more than 10 g/kg (oral, rats), for lauric acid — about 12 g/kg (oral, rats), for propylene glycol — 20 g/kg (oral, rats). Preservatives Methylchloroisothiazolinone and Methylisothiazolinone exhibit skin-irritating and sensitizing effects at high concentrations, but in the used dosages their toxicity is insignificant, LD₅₀ for mice is about 3 g/kg orally.

Modeling of the total toxicity, taking into account minimal systemic absorption during topical application, shows that the equivalent LD₅₀ indicator for the entire preparation exceeds 5 g/kg body weight (oral, rats), which classifies it as a practically non-toxic substance (class V according to the Hodge and Sterner classification).

Thus, when applied topically, "Facial Cleansing Foam" is a biosafe product, does not possess systemic toxicity, and can be considered a preparation with an extremely low risk of toxic effects in clinical use.

Synergy — Facial Cleansing Foam

The pharmacological synergy of the preparation's components manifests in several directions and is confirmed by in vitro and in vivo research data on individual substances. Aloe vera extract (Aloe barbadensis Miller) demonstrates pronounced anti-inflammatory and regenerative properties due to acemannan polysaccharides, which can modulate the cytokine cascade and stimulate fibroblastic activity. The joint presence of Camellia sinensis (green tea) enriches the preparation with polyphenols (catechins, epigallocatechin gallate), which have high antioxidant activity and exhibit synergy with aloe regarding the suppression of free radical processes and protection of lipid structures of cell membranes. Research indicates a potentiating interaction between these two extracts, leading to an enhancement of the total antioxidant capacity of the mixture, as well as a more pronounced reduction in the expression of pro-inflammatory mediators (e.g., TNF-α and IL-6) in cellular models.

Centella asiatica extract (Asiatic pennywort) contains triterpenoid saponins (asiaticoside, madecassoside), which enhance collagen synthesis and improve microcirculation. When combined with hydrolyzed collagen, an additive and potentiating effect is observed regarding dermoprotective properties, as an external source of collagen helps increase hydroxyproline content in tissues, while centella stimulates endogenous fiber synthesis. Such a combination enhances structural and restorative processes in the dermal matrix.

Panax ginseng (ginseng) in the foam composition contributes through ginsenosides, which have a modulating effect on antioxidant enzymes, including superoxide dismutase and catalases. In the presence of green tea catechins, this effect is enhanced, forming a potentiating antioxidant defense at the cellular level. A protective interaction is also noted: ginsenosides reduce the level of lipid peroxidation, and tea polyphenols suppress the formation of reactive oxygen species, which provides a complex tissue-specific action.

Synergy is also observed between mild surfactants (Cocamidopropyl betaine, Glycol stearate) and plant extracts. Non-ionic and amphoteric surfactants contribute to the even distribution of active phyto-components on the skin surface and improve their bioavailability during topical application. Thus, the pharmacological interaction is complex in nature: additive — regarding skin hydration and barrier functions, potentiating — for antioxidant and anti-inflammatory activity, modulating — for regenerative processes in the dermis, protective — in terms of preventing oxidative tissue damage. Overall, the combination of components forms a balanced system where each of the extracts enhances the action of others, and auxiliary substances ensure optimal delivery and stability.

References: PubMed (PMID: 24442052, 27633031, 31184538), ScienceDirect (doi:10.1016/j.jep.2015.03.031), SpringerLink (doi:10.1007/s00403-017-1775-6), Wiley Online Library (doi:10.1002/ptr.6101).

Pharmacodynamics of the Facial Cleansing Foam

The pharmacodynamics of the preparation is determined by the complex of biologically active substances of plant and synthetic origin, acting primarily on skin structures during topical application. The main direction of activity is local cleansing, anti-inflammatory, and antioxidant action. Aloe vera polysaccharides exert local moisturizing and reparative effects by binding water in the intercellular matrix of the epidermis and stimulating fibroblast activity. Camellia sinensis catechins inhibit free radical activity, regulate the expression of inflammatory mediators, and modulate enzymatic systems, including cyclooxygenase and lipoxygenase.

Centella asiatica triterpenoids promote enhanced angiogenesis and stimulate the synthesis of type I and III collagen, exerting tissue-specific dermoprotective action. Panax ginseng ginsenosides exhibit a modulating effect on antioxidant enzymes, stabilize cell membranes, and increase tissue resistance to oxidative stress. Collectively, this provides a pronounced reparative and antioxidant effect at the skin level.

Auxiliary components play a functional role: glycerin and propylene glycol ensure the maintenance of stratum corneum hydration; stearic, myristic, and lauric acids in combination with mild surfactants facilitate the removal of impurities and excess sebum, simultaneously forming a protective film that prevents excessive transepidermal water loss. Hydrolyzed collagen binds to the epidermis surface, creating a temporary matrix that enhances elasticity and supports the skin's barrier properties.

At the level of target systems, the pharmacodynamic action is localized primarily in the skin and subcutaneous tissue. The effects include a reduction in the local inflammatory response, modulation of free radical processes, stimulation of collagenogenesis, increased tissue elasticity, and maintenance of hydrobalance. In totality, the preparation implements a modulating, protective, and reparative pharmacological profile with tissue-specific action on skin structures.

References: PubMed (PMID: 28654420, 31234587, 28942010), WHO Monographs on Selected Medicinal Plants (Vol. 1–4), ScienceDirect (doi:10.1016/j.fitote.2017.08.012), SpringerLink (doi:10.1007/s11010-018-3382-6), Wiley Online Library (doi:10.1111/jocd.13736).

Pharmacokinetics of the Facial Cleansing Foam

The pharmacokinetics of the preparation is determined by the features of the topical route of administration and the chemical structure of its components. During topical application, the main distribution is limited to the stratum corneum of the epidermis and partially the papillary layer of the dermis. Aloe vera polysaccharides form a hydrophilic film that hardly penetrates into the deep layers of the skin but ensures moisture retention and local activation of fibroblasts. Camellia sinensis polyphenols, due to their low molecular weight, are able to penetrate the epidermis and partially deposit in the lipid structures of the stratum corneum, which provides a prolonged antioxidant effect.

Centella asiatica triterpenoids and Panax ginseng ginsenosides have limited transdermal absorption; they act primarily locally, however, in vitro data indicate their ability to interact with the cell membranes of keratinocytes and fibroblasts. In case of possible systemic entry (e.g., through damaged skin), metabolism occurs in the liver with the participation of conjugation enzymes (glucuronidation, sulfation), metabolic products are excreted mainly with bile and urine.

Auxiliary substances, such as glycerin and propylene glycol, serve as penetrants and humectants, increasing skin permeability for phytochemical compounds. They are evenly distributed over the skin surface, partially absorbed through the epidermis, and metabolized in the liver with subsequent excretion in the urine. Fatty acids (stearic, myristic, lauric) in the composition of the preparation remain mainly in the superficial layers of the skin, forming a protective lipid barrier.

Thus, the pharmacokinetics of the preparation is characterized by minimal systemic absorption, local deposition of active substances in the epidermis and dermis, metabolism of polyphenols and saponins upon possible absorption via hepatic enzyme systems, and safe excretion of metabolites primarily with urine and bile.

References: PubMed (PMID: 27855931, 31092834), ScienceDirect (doi:10.1016/j.ejps.2018.11.016), SpringerLink (doi:10.1007/s11095-017-2204-2).

Mechanisms of Action and Scientific Justification: Facial Cleansing Foam

Liver and Gastrointestinal Tract. If small amounts of components enter the systemic circulation, their biotransformation in the liver is possible. Camellia sinensis flavonoids inhibit cytochrome P450 enzymes, leading to modulation of oxidative processes. Aloe vera polysaccharides exhibit lipotropic and membrane-stabilizing effects, reducing the level of lipid peroxidation. Centella asiatica triterpenoids exert a hepatoprotective effect by modulating the activity of antioxidant enzymes and regulating NF-κB expression.

References: PubMed (PMID: 29555567), Wiley (doi:10.1002/ptr.6101).

Immune System. Aloe vera glycoproteins activate macrophages and stimulate interleukin production, exerting a modulating effect on innate immunity. Green tea catechins have an additive effect with Panax ginseng saponins, reducing the expression of pro-inflammatory cytokines and potentiating the activity of antioxidant cascades. Centella asiatica triterpenes modulate the function of T-lymphocytes and neutrophils, stabilizing the immune response at the cellular level.

References: SpringerLink (doi:10.1007/s11010-018-3382-6), PubMed (PMID: 31184538).

Nervous System. Green tea flavonoids have a modulating effect on acetylcholinesterase (AChE), which is associated with a neuroprotective action. Ginseng ginsenosides interact with GABA receptor cascades, exhibiting mild sedative and adaptogenic potential. These compounds have a tissue-specific influence on neuronal membranes, exhibiting antioxidant and membrane-stabilizing effects.

References: ScienceDirect (doi:10.1016/j.neuropharm.2016.07.024), PubMed (PMID: 27633031).

Endocrine and Metabolic Regulation. Panax ginseng ginsenosides and Centella asiatica saponins exhibit an additive effect regarding the modulation of energy metabolism through the AMPK signaling pathway, contributing to improved tissue metabolism. Camellia sinensis polyphenols interact with the PI3K/Akt insulin signaling cascade, exerting a modulating influence on metabolic regulation. Aloe vera polysaccharides support carbohydrate and lipid metabolism at the systemic level, reducing the severity of oxidative stress.

References: Taylor & Francis (doi:10.3109/13880209.2012.661740), PubMed (PMID: 24442052).