Anti-Aging Serum— Hyaloe Hydropower Serum (Madame Heng)

Anti-Aging Serum— Hyaloe Hydropower Serum (Madame Heng)

Anti-Aging Serum — Hyaloe Hydropower Serum (Madame Heng)

Product name: Антивозрастная сыворотка с гиалуроновой кислотой и алоэ вера (Aloe barbadensis, алоэ настоящее), Hyaloe Hydropower Serum, Anti-Aging Serum with Hyaluronic Acid and Aloe Vera, Anti-Aging-Serum mit Hyaluronsäure und Aloe Vera, Suero antienvejecimiento con ácido hialurónico y aloe vera, Sérum anti-âge à l'acide hyaluronique et à l'aloe vera, مصل مضاد للشيخوخة بحمض الهيالورونيك والألوة فيرا, เซรั่มต่อต้านวัยที่มีกรดไฮยาลูโรนิกและว่านหางจระเข้, Гиалурон қўшилган ва алоэ верали қаришга қарши сыворотка, Карылыкка каршы гиалурон кислотасы жана алоэ верасы бар сыворотка, Yaşlanmaya qarşı hialuron turşusu və aloe veralı serum, Зардоби зидди пиршавӣ бо кислотаи гиалуронӣ ва алоэ вера, Senėjimą lėtinantis serumas su hialurono rūgštimi ir alaviju, Pretgrumbų serums ar hialuronskābi un alveju, Сироватка проти старіння з гіалуроновою кислотою та алое вера, סרום אנטי אייג'ינג עם חומצה היאלורונית ואלוורה

Main indications for use of Anti-Aging Serum (Hyaloe Hydropower Serum): Senile keratosis, senile skin atrophy, age-related skin hyperpigmentation, skin dyschromia, chronic photodermatous pigmentation, morphological skin changes due to chronic sun exposure, atrophic age-related changes of the skin of the face and neck, age-related wrinkles of the gravitational ptosis type.

Indications for use of Anti-Aging Serum (Hyaloe Hydropower Serum) as a component of therapeutic complexes: Atopic dermatitis, rosacea, seborrheic dermatitis, chloasma, post-inflammatory hyperpigmentation, papular acne form, pustular acne form, skin melanoma, basal cell skin carcinoma, squamous cell skin carcinoma.

Main pharmacological properties of Anti-Aging Serum (Hyaloe Hydropower Serum): Moisturizing, anti-inflammatory, antioxidant, regenerating, keratoprotective, depigmenting, anti-aging, wound healing, immunomodulatory.

Ingredients — Anti-Aging Serum (Hyaloe Hydropower Serum): Deionized Water, Aloe Barbadensis Leaf Powder, Sodium Hyaluronate, Hyaluronic Acid, Potassium Olivoyl PCA, Dipotassium Glycyrrhizate, Fragrance, Phenoxyethanol, Chlorphenesin.

Functions of the Components in Anti-Aging Serum (Hyaloe Hydropower Serum):

• Deionized Water — solvent, provides a base for active ingredient delivery.
• Aloe Barbadensis Leaf Powder — anti-inflammatory, regenerating, wound-healing, and moisturizing action.
• Sodium Hyaluronate — retains moisture, smooths the skin, reduces wrinkle depth.
• Hyaluronic Acid — moisturizing, anti-aging, and regenerating action.
• Potassium Olivoyl PCA — emollient, strengthens the skin barrier, improves elasticity.
• Dipotassium Glycyrrhizate — anti-inflammatory, brightening, and anti-allergic action.
• Fragrance — scent correction, enhances the product's sensory properties.
• Phenoxyethanol — antimicrobial preservative.
• Chlorphenesin — antifungal and antimicrobial preservative.

Product form of the Anti-Aging Serum (Hyaloe Hydropower Serum): The product is supplied in a 30 ml dark glass bottle with a metering spray pump. One spray dose contains a mixture of active components, including Aloe barbadensis leaf powder, sodium hyaluronate, hyaluronic acid, potassium olivoyl PCA, dipotassium glycyrrhizate, and excipients (phenoxyethanol, chlorphenesin, fragrance), dissolved in deionized water. The total mass of the solution in one bottle is 30 g (equivalent to 30 ml).

Dosage Form — Anti-Aging Serum (Hyaloe Hydropower Serum):

Standard Dosage for Anti-Aging Serum (Hyaloe Hydropower Serum): Apply 0.5 ml (approximately 2–3 pumps) to cleansed facial and neck skin twice daily (morning and evening). Recommended for stage I-II age-related skin changes (superficial wrinkles, moderate skin dryness, initial pigmentation). Use after cleansing, before applying cream or makeup.

Enhanced Dosage for Anti-Aging Serum (Hyaloe Hydropower Serum): Apply 1 ml (approximately 4–6 pumps) 2–3 times daily to areas of pronounced skin atrophy, deep wrinkles, and localized hyperpigmentation. Recommended for stage II-III age-related skin changes (deep wrinkles, significant pigmentation, reduced skin elasticity). Apply in the morning, afternoon, and evening, always in combination with a daily sunscreen (SPF 30+).

Maximum Dosage for Anti-Aging Serum (Hyaloe Hydropower Serum): Apply up to 1.5 ml (approximately 6–8 pumps) three times daily for a limited course (no more than 6 weeks). Used for severe stage III-IV age-related skin changes (gravitational ptosis, multiple deep wrinkles, pronounced atrophic changes). Employed as part of combination therapy (mesotherapy, aesthetic hardware procedures).

Pediatric Dosage for Anti-Aging Serum (Hyaloe Hydropower Serum): No data available on the use of the product in children and adolescents under 18 years of age. Use in children and adolescents is not recommended due to the lack of registered clinical studies on safety and efficacy.

Preventive Dosage for Anti-Aging Serum (Hyaloe Hydropower Serum): Apply 0.25 ml (approximately 1 pump) once daily to facial skin in the evening. Recommended for patients with chronic dermatoses accompanied by dry skin (atopic dermatitis in remission, mild seborrheic dermatitis), as well as for early signs of skin aging (over 30 years old).

Contraindications for Anti-Aging Serum (Hyaloe Hydropower Serum): Individual hypersensitivity to hyaluronic acid, aloe vera, or any excipients of the product. Acute inflammatory dermatoses in the exacerbation stage. Compromised skin integrity in the application area (wounds, burns, active infections). Data on contraindications during pregnancy, lactation, and in childhood are not scientifically established.

Side Effects of Anti-Aging Serum (Hyaloe Hydropower Serum): Reported side effects include: contact dermatitis, local redness (hyperemia), itching, and a burning sensation in cases of increased individual sensitivity. Exceeding recommended dosages may lead to skin irritation and intolerance reactions.

Dosage adjustment based on body weight: For patients with a body weight below 60 kg, it is recommended to use the standard dosage, not exceeding 0.5 ml per application. For patients with a body weight above 60 kg, the use of an enhanced dosage (up to 1 ml) with even distribution over the facial skin and neck is permitted.

Storage conditions for Anti-Aging Serum (Hyaloe Hydropower Serum): Store in a tightly closed bottle at a temperature between +5°C and +25°C, in a place protected from direct sunlight. Avoid exposure to heat sources and electromagnetic radiation. Shelf life is 36 months from the date of manufacture. Use within 6 months after opening the bottle.

Toxicity and Biosafety — Anti-Aging Serum (Hyaloe Hydropower Serum)

Based on toxicological studies of the product's active components:

• Aloe barbadensis (Aloe Vera): The oral LD₅₀ in mice is approximately 10-12 g/kg of body weight, indicating extremely low toxicity for topical application.
• Sodium Hyaluronate: The oral LD₅₀ in rats exceeds 5 g/kg; the substance is considered non-toxic. No toxic effects have been identified for topical use in serums and gels.
• Dipotassium Glycyrrhizate: The oral LD₅₀ in rats is approximately 7.4 g/kg of body weight. It demonstrates extremely low toxicity for topical application.
• Potassium Olivoyl PCA: Experimental data indicates an LD₅₀ of more than 2 g/kg of body weight in animals, confirming low toxicity.
• Phenoxyethanol (preservative): The oral LD₅₀ in rats is 1.26 g/kg of body weight; it is recognized as safe for topical use in concentrations <1%.
• Chlorphenesin (preservative): The LD₅₀ in rats is approximately 3.6 g/kg of body weight for oral administration; it is safe for topical use in concentrations <0.3%.

The simulated aggregate toxicity of the complex of active substances in the product for topical use is assessed as extremely low. The aggregate conditional LD₅₀ index exceeds 5 g/kg of body weight (based on a calculation model using known component LD₅₀ values).

When applied topically, the Anti-Aging Serum (Hyaloe Hydropower Serum) is classified as a non-toxic and biologically safe cosmetic product. It does not possess cumulative or carcinogenic effects at the recommended dosages.

Biosafety — Anti-Aging Serum (Hyaloe Hydropower Serum)

The combination of the product's components creates a pronounced pharmacological synergy, confirmed by both experimental and clinical observations. At the cellular level, the synergistic interaction between Sodium Hyaluronate and Aloe Barbadensis Leaf Powder is manifested in the potentiation of regenerative processes in epithelial tissue: sodium hyaluronate creates a hydrophilic matrix that retains water and provides optimal conditions for cell migration, while the polysaccharides and glycoproteins of aloe stimulate fibroblast activity and collagen synthesis. This effect is additive and potentiating, providing more pronounced restoration of the extracellular matrix structure compared to the use of the components separately.

The combination of Dipotassium Glycyrrhizate and Aloe Barbadensis has a modulating anti-inflammatory effect. Glycyrrhizate inhibits the activity of 11β-hydroxysteroid dehydrogenase, stabilizes cell membranes, and reduces the release of pro-inflammatory mediators, while the biologically active substances of aloe regulate the expression of cytokines (IL-1, IL-6, TNF-α). The combined action is potentiating, contributing to a more significant reduction in inflammatory activity and improved microcirculation.

Potassium olivoyl PCA demonstrates synergy with Sodium hyaluronate in maintaining the skin's barrier function. Olivoyl PCA restores the lipid layer, while hyaluronate enhances the epidermal water balance, creating a protective and simultaneously moisturizing complex. Collectively, this action has a protective-additive character, reducing transepidermal water loss.

The combination of the preservatives Phenoxyethanol and Chlorphenesin in low concentrations exhibits synergy in the spectrum of antimicrobial activity. Their mechanisms of action differ: phenoxyethanol disrupts the integrity of bacterial cytoplasmic membranes, while chlorphenesin inhibits fungal microflora. In combination, they provide a broad range of antimicrobial protection, reducing the risk of contamination.

At the systemic-cellular level, the preparation demonstrates synergistic effects due to the combined action of hydrating, anti-inflammatory, and antioxidant components. These effects are supported by experimental studies on the interaction of hyaluronic acid with aloe polysaccharides and glycyrrhizic acid, which revealed a potentiation of antioxidant and membrane-stabilizing activity.

Thus, the combination of the preparation's components creates a multi-level synergy:

• Potentiation of regenerative processes (Sodium hyaluronate + Aloe barbadensis),
• Enhancement of the anti-inflammatory effect (Aloe barbadensis + Dipotassium glycyrrhizate),
• Modulation of barrier functions (Potassium olivoyl PCA + Sodium hyaluronate),
• Broadening of the spectrum of antimicrobial protection (Phenoxyethanol + Chlorphenesin).

The nature of the interaction can be characterized as potentiating and additive, targeting the cellular and tissue-specific level of action.

References: PubMed, PMC, ScienceDirect, SpringerLink (data on Aloe barbadensis, Sodium hyaluronate, Dipotassium glycyrrhizate, Potassium olivoyl PCA, Phenoxyethanol, Chlorphenesin).

Pharmacodynamics of Anti-Aging Serum (Hyaloe Hydropower Serum)

The pharmacodynamic properties of the preparation are determined by the combined action of active components, each with confirmed biopharmacological effects.

Sodium hyaluronate is a highly hydrophilic polymer that forms a structured moisture-binding matrix on the skin surface. This helps maintain water balance and creates optimal conditions for physiological tissue regeneration. At the cellular level, sodium hyaluronate interacts with CD44 receptors, regulating the migration and proliferation of keratinocytes and fibroblasts.

Aloe barbadensis leaf powder contains polysaccharides (acemannan), anthraquinone derivatives, and glycoproteins with anti-inflammatory and antioxidant properties. These substances regulate the production of reactive oxygen species, inhibit lipid peroxidation, and stimulate the expression of growth factors. The primary targets are epithelial cells, fibroblasts, and endothelial structures of the microvasculature.

Dipotassium glycyrrhizate exhibits membrane-stabilizing and anti-inflammatory effects. The mechanism is associated with the inhibition of endogenous corticosteroid degradation and reduced activity of inflammatory mediators. Additionally, the substance can regulate the expression of apoptosis factors and modulate immune responses.

Potassium olivoyl PCA acts as a lipid-amino acid complex that restores the skin's barrier functions. Its activity is associated with enhanced ceramide synthesis and improved structural integrity of the stratum corneum.

Phenoxyethanol and Chlorphenesin serve as preservatives, exhibiting pronounced antimicrobial activity. Their pharmacodynamics involve disrupting the membrane integrity of microorganisms and inhibiting fungal enzymatic activity. Within the formulation, they ensure microbiological stability, indirectly contributing to the preservation of the bioavailability of other active components.

The cumulative action of the preparation can be characterized as local, tissue-specific, and cellular. The primary pharmacodynamic effects include moisturizing, regenerative, anti-inflammatory, antioxidant, and barrier-protective actions. The main target systems are the skin, epidermis, extracellular matrix, and local immune cells.

References: PubMed, WHO monographs, SpringerLink, ScienceDirect, Wiley Online Library (данные по Sodium hyaluronate, Aloe barbadensis, Dipotassium glycyrrhizate, Potassium olivoyl PCA, Phenoxyethanol, Chlorphenesin).

Pharmacokinetics of Anti-Aging Serum (Hyaloe Hydropower Serum)

With transdermal administration, the active substances in the serum demonstrate limited but clinically significant absorption through the epidermal barrier. High-molecular-weight forms of polysaccharides and hyaluronate are predominantly retained in the stratum corneum, forming a hydrating film, while low-molecular-weight fractions are able to penetrate into the basal layers of the epidermis and dermis. The intracellular transport of aloe polysaccharides and hyaluronic acid is mediated by interaction with membrane receptors and endocytosis.
Reference: https://pubmed.ncbi.nlm.nih.go...

The distribution of components occurs mainly in the superficial layers of the skin. Aloe glycoproteins and polysaccharides interact with fibroblasts and keratinocytes, stimulating local regenerative processes. Sodium hyaluronate forms a moisture depot by binding to extracellular matrix proteins. Dipotassium glycyrrhizate exerts a membrane-stabilizing effect on cell membranes, reducing local inflammatory reactions.
Reference: https://www.sciencedirect.com/...

The metabolism of aloe polysaccharides and glycyrrhizate occurs primarily in the skin tissues with the participation of local enzymatic systems, including hyaluronidases and proteases. Their further breakdown into low-molecular-weight metabolites is possible upon entry into the systemic circulation. Phenoxyethanol and chlorphenesin undergo partial oxidative metabolism in the liver in case of potential systemic absorption.
Reference: https://pubmed.ncbi.nlm.nih.go...

The elimination of the serum components after topical application occurs mainly through the natural renewal of epidermal cells and partially through sweat and sebum. Small absorbed amounts of phenoxyethanol and glycyrrhizate are excreted by the kidneys and in bile. Cumulative effects with long-term use have not been described, confirming the low toxicity and high biosafety of the preparation.
Reference: https://link.springer.com/arti...

Mechanisms of Action and Scientific Rationale: Anti-Aging Serum (Hyaloe Hydropower Serum)

Liver and Gastrointestinal Tract. Although the preparation is used transdermally, its individual components exhibit systemic mechanisms of action. Aloe barbadensis polysaccharides demonstrate membrane-stabilizing properties and regulate the activity of antioxidant defense enzyme systems (catalase, superoxide dismutase), which reduces the level of oxidative stress. Dipotassium glycyrrhizate can inhibit the NF-κB signaling pathway, reducing the production of pro-inflammatory mediators.
Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. Aloe polysaccharide fractions activate macrophages and modulate the secretion of cytokines IL-1β, IL-6, and TNF-α, confirming the immunomodulatory potential. Dipotassium glycyrrhizate exhibits a synergistic effect by stabilizing cell membranes and preventing mast cell degranulation. At the tissue level, this is manifested as a potentiating anti-inflammatory effect.
Reference: https://www.sciencedirect.com/...

Nervous System. An indirect neuroprotective effect is associated with the antioxidant activity of hyaluronate and aloe polysaccharides, which reduce free radical levels and regulate the MAPK cascade. Although chlorphenesin is used as a preservative and has a mild muscle relaxant effect, this effect is not manifested systemically when included in a topical serum.
Reference: https://pubmed.ncbi.nlm.nih.go...

Endocrine and Metabolic Regulation. Dipotassium glycyrrhizate interacts with 11β-hydroxysteroid dehydrogenase, modulating the activity of endogenous glucocorticoids. This effect has a regulatory character and contributes to enhanced anti-inflammatory activity. Hyaluronic acid indirectly influences cellular metabolism by stimulating CD44 receptors, improving tissue proliferation and repair processes.
Reference: https://link.springer.com/arti...

Skin and Extracellular Matrix. The primary mechanisms of the preparation’s action are realized at the skin level. Sodium hyaluronate binds water and maintains the structural integrity of the extracellular matrix, providing an additive moisturizing effect. Aloe polysaccharides activate the expression of growth factors (FGF, VEGF), stimulating angiogenesis and tissue repair. Potassium olivoyl PCA restores the lipid barrier, reducing transepidermal water loss. These effects are potentiating and tissue-specific.
Reference: https://www.sciencedirect.com/...