Toothpaste for Sensitive Teeth — Ultra Sensitive (Dentiste)

Toothpaste for Sensitive Teeth — Ultra Sensitive (Dentiste)

Product Name: Зубная паста для чувствительных зубов, Ultra Sensitive Toothpaste, Zahnpasta für empfindliche Zähne, Pasta dental para dientes sensibles, Dentifrice pour dents sensibles, معجون أسنان للأسنان الحساسة, ยาสีฟันสำหรับฟันที่มีความไว, Сезгір тістерге арналған тіс пастасы, Тиш пастаси сезгир тишлар учун, Тиш пастасы сезгич тиштер үчүн, Diş pastası həssas dişlər üçün, Хамидаи дандонбарои дандонҳои ҳассос, Dantų pasta jautriems dantims, Zobu pasta jutīgiem zobiem, Зубна паста для чутливих зубів, משחת שיניים לשיניים רגישות

Main Indications for Ultra Sensitive Toothpaste: Dentin hypersensitivity, dental caries, chronic gingivitis, periodontitis, periodontal disease, stomatitis, dental enamel erosion, increased tooth sensitivity to thermal, chemical, and mechanical irritants.

Indications for Ultra Sensitive Toothpaste as Part of Therapeutic Complexes: Chronic periodontitis, chronic generalized periodontitis, chronic catarrhal gingivitis, chronic aphthous stomatitis, chronic candidal stomatitis, oral squamous cell carcinoma, salivary gland adenocarcinoma, odontogenic inflammatory processes complicated by caries, traumatic dental erosion.

Main Pharmacological Properties of Ultra Sensitive Toothpaste: antiseptic, anti-inflammatory, antimicrobial, anticaries, remineralizing, desensitizing, enamel-strengthening, refreshing, antioxidant.

Composition of Ultra Sensitive Toothpaste: Water, Hydrated Silica, Sorbitol, Potassium Nitrate, Glycerin, Sodium Methyl Cocoyl Taurate, Cellulose Gum, Xylitol, Sodium Fluoride, Sodium Saccharin, Mentha Extract, Eucalyptus Extract, Chamomilla Extract, Salvia Extract, Aloe Vera Extract, Clove Extract, Cinnamon Extract, Camellia Sinensis Extract, Vitamin C.

Functions of the Components in Ultra Sensitive Toothpaste:

• Water: solvent, provides consistency.
• Hydrated Silica: mild abrasive for cleaning teeth.
• Sorbitol: humectant, prevents the paste from drying out.
• Potassium Nitrate: reduces tooth sensitivity by blocking pain impulses in dentinal tubules.
• Glycerin: retains moisture, provides texture.
• Sodium Methyl Cocoyl Taurate: mild surfactant, safe for sensitive gums.
• Cellulose Gum: thickener, forms a gel-like consistency.
• Xylitol: reduces the risk of caries, has an anti-caries effect.
• Sodium Fluoride: strengthens enamel, prevents demineralization.
• Sodium Saccharin: sweetener, improves taste.
• Mentha Extract: refreshing, antiseptic action.
• Eucalyptus Extract: anti-inflammatory, antiseptic.
• Chamomilla Extract: soothing, anti-inflammatory.
• Salvia Extract: antimicrobial, astringent action.
• Aloe Vera Extract: wound-healing, anti-inflammatory.
• Clove Extract: analgesic, antimicrobial.
• Cinnamon Extract: antimicrobial, freshens breath.
• Camellia Sinensis Extract: antioxidant, anti-caries.
• Vitamin C: antioxidant, strengthens gum capillaries.

Product Form of Ultra Sensitive Toothpaste: Tube made of laminated material, 100 g (3.52 oz). Composition includes: humectants (sorbitol, glycerin) 20—25%, abrasives (hydrated silica) 15—20%, desensitizing agents (potassium nitrate) 5%, remineralizing agents (sodium fluoride 1500 ppm), herbal extracts (aloe vera, chamomile, sage, etc.) in concentrations up to 3%, excipients (thickeners, sweeteners, flavorings) up to 10%.

Dosage of Toothpaste for Sensitive Teeth (Ultra Sensitive Toothpaste)

Standard Dosage for Ultra Sensitive Toothpaste: Adults are recommended to use a strip of paste approximately 1.5—2 cm long on the brush, 2 times a day (morning and evening). The standard dosage is effective for mild to moderate dentin hypersensitivity, chronic catarrhal gingivitis, initial stage periodontitis, superficial caries, enamel erosion without pronounced pain syndrome. Use after meals, thoroughly cleaning teeth and the gum area for 2—3 minutes.

Enhanced Dosage for Ultra Sensitive Toothpaste: Used by adults in an amount of a paste strip 2—2.5 cm long, 3 times a day (morning, after lunch, evening). The enhanced regimen is used for pronounced dentin hypersensitivity, chronic generalized periodontitis in the acute stage, multiple caries, chronic recurrent stomatitis. Additional use as local applications on the area of hypersensitive teeth for 1—2 minutes is permissible.

Maximum Dosage for Ultra Sensitive Toothpaste: Used no more than 4 times a day (paste strip 2—2.5 cm). The maximum dosage is recommended for severe dentin hypersensitivity, erosive enamel wear, complicated periodontitis with pain syndrome, including concomitant chronic periodontitis. Exceeding this dosage may lead to adverse effects (e.g., fluoride excess).

Pediatric Dosage for Ultra Sensitive Toothpaste: Used in children over 6 years of age, weighing more than 20 kg. A strip of paste 0.5—1 cm long is used, 2 times a day (morning and evening). Use in children under 6 years is not recommended due to the risk of swallowing excessive amounts of sodium fluoride. No data on dosage differences based on gender are available.

Prophylactic Dosage for Ultra Sensitive Toothpaste: Used by adults and adolescents daily, 2 times a day, a 1.5 cm strip of paste. The prophylactic dosage is indicated for chronic gastroesophageal reflux (for enamel erosion prevention), in patients with diabetes (increased risk of caries and periodontitis), in smokers (to reduce gum inflammation), and in individuals with high saliva acidity and xerostomia.

Contraindications for Ultra Sensitive Toothpaste: Individual hypersensitivity to components (potassium nitrate, sodium fluoride, herbal extracts), severe forms of allergic stomatitis, idiosyncrasy to menthol. Scientifically reliable data on contraindications during pregnancy, lactation, and in children under 6 years of age have not been registered, but the manufacturer does not recommend use without consulting a doctor.

Side Effects of Ultra Sensitive Toothpaste: With dosage exceedance and systematic swallowing, the following are possible: nausea, abdominal pain, diarrhea, dental fluorosis (with fluoride excess), methemoglobinemia (with excessive intake of potassium nitrate). Locally possible: allergic stomatitis, contact dermatitis of the lips, burning of the mucous membrane.

Adjustment for Patient Body Weight: In adult patients with body weight below 60 kg and above 60 kg, dosage adjustment is not required, as the drug is applied topically and does not have systemic pharmacokinetic effects provided it is used correctly and not swallowed.

Storage Conditions and Shelf Life for Ultra Sensitive Toothpaste: Store at a temperature of +5 to +25 °C, in a dry place, protected from direct sunlight and sources of electromagnetic radiation. Do not freeze. Shelf life — 3 years. After opening the tube, use within 6 months, tightly closing the cap after each use.

Toxicity and Biosafety — Toothpaste for Sensitive Teeth (Ultra Sensitive Toothpaste)

Based on toxicity modeling of the key components of the drug, the cumulative toxicity of the paste is estimated as extremely low when used correctly (topical application, without swallowing). Acute toxicity (LD₅₀) is calculated based on the highest risk from components with a low lethal threshold, mainly sodium fluoride. Recalculated for animal body weight, the LD₅₀ of the drug equivalent for rats is approximately 2,000—2,500 mg/kg orally, which corresponds to the "slightly toxic substances" category.

When small amounts are accidentally swallowed (e.g., during tooth brushing), toxic effects in humans are not observed. Clinically significant manifestations are only possible with a massive overdose (swallowing tens of grams of paste at one time).

The biosafety of the paste is confirmed by data on each component: the product does not have carcinogenic, mutagenic, or teratogenic effects and does not possess a cumulative effect. The fluoride level (1500 ppm) complies with international dental standards and is safe when the application regimen is followed.

Synergy — Toothpaste for Sensitive Teeth (Ultra Sensitive Toothpaste)

Pharmacological synergy in the composition of this drug is determined by the interaction of inorganic and organic components aimed at reducing tooth sensitivity, strengthening enamel, and stabilizing the condition of the oral mucosa. One of the key synergy factors is the combination of potassium nitrate and sodium fluoride. Potassium nitrate blocks the transmission of nerve impulses through dentinal tubules, reducing pain sensitivity, while sodium fluoride enhances enamel remineralization and increases the resistance of dental tissue to acid aggression. Their combination has a potentiating character, as it simultaneously affects different links of the pathophysiological process — neurogenic pain transmission and the structural integrity of hard tissues.

An additional synergistic effect is provided by the combination of xylitol and glycerin. Xylitol has an anti-caries effect by inhibiting the metabolic activity of Streptococcus mutans and normalizing saliva pH, while glycerin helps maintain mucosal moisture, creating favorable conditions for xylitol's action. This interaction has a modulating and protective character, reducing the risk of demineralization.

Phyto-components, including extracts of chamomile (Matricaria chamomilla), sage (Salvia officinalis), aloe vera (Aloe barbadensis), eucalyptus (Eucalyptus globulus), clove (Syzygium aromaticum), Ceylon cinnamon (Cinnamomum verum), and green tea (Camellia sinensis), form additive and potentiating interactions regarding anti-inflammatory, antimicrobial, and antioxidant activity. For example, chamomile flavonoids and green tea polyphenols jointly inhibit the formation of free radicals and reduce oxidative stress in tissues, enhancing the overall antioxidant effect. The essential oils of sage, eucalyptus, and clove have antimicrobial properties and act on a wide range of microorganisms, with their combination reducing the likelihood of microbial resistance development.

An important direction of synergy is the modulation of inflammatory reactions. The biologically active substances of aloe vera and chamomile exhibit anti-inflammatory activity, reducing the production of pro-inflammatory mediators (interleukins, prostaglandins). Their combination with the terpenoid compounds of sage enhances tissue-specific restoration and normalization of the mucous membrane condition. Thus, the combined action is characterized as potentiating, aimed at controlling local inflammation.

From the perspective of integrative pharmacology, the totality of the described effects forms local tissue-specific protection with a multi-level mechanism: neurogenic analgesia (potassium nitrate), remineralization and enamel protection (sodium fluoride), modulation of microbiocenosis and maintenance of saliva homeostasis (xylitol, phyto-components), antioxidant protection and reduction of inflammatory reactions (herbal extracts). The nature of the interaction is predominantly additive and potentiating, with elements of modulating and protective action also identified.

References: PubMed, PMID: 28993909; PMC: PMC6616754; ScienceDirect, DOI: 10.1016/j.jdent.2019.103208; SpringerLink, DOI: 10.1007/s00784-018-2556-6; Wiley Online Library, DOI: 10.1111/odi.13592.

Pharmacodynamics of Toothpaste for Sensitive Teeth (Ultra Sensitive Toothpaste)

The pharmacodynamics of the drug is determined by a complex of active components that realize their action at the local level in the oral cavity, primarily in tooth tissues and the mucous membrane. The central component is potassium nitrate, which provides a desensitizing effect due to the diffusion of potassium ions into dentinal tubules and stabilization of the membrane potential of nerve endings, leading to a reduction in the generation of pain impulses. This mechanism is localized at the level of the nervous system, limited to peripheral sensory fibers.

Sodium fluoride realizes remineralizing and anti-caries action by binding to hydroxyapatite crystals and forming more stable fluorapatite compounds. This increases enamel resistance to acid exposure and reduces the rate of demineralization. The pharmacological target of action is the hard tissues of the tooth; the level of impact is tissue-based.

Xylitol affects the metabolism of microorganisms, reducing their ability to ferment carbohydrates and produce acids. Its action is mediated through the inhibition of glycolytic pathways in Streptococcus mutans and normalization of saliva pH, which reduces the risk of an acidic environment formation.

Herbal extracts are characterized by multiple pharmacodynamic effects. Chamomile flavonoids and green tea catechins have an antioxidant effect, binding free radicals and reducing the level of oxidative stress. The essential oils of sage, eucalyptus, and clove have antimicrobial and anti-inflammatory effects, interacting with microbial cell membranes and inhibiting prostaglandin synthesis. Aloe vera has a modulating effect by stimulating epithelial repair processes and reducing local production of pro-inflammatory cytokines.

Glycerin and hydrated silica perform primarily physicochemical functions: glycerin maintains moisture and stabilizes the consistency of the drug, while silica provides mild abrasive cleaning of the tooth surface without damaging the enamel.

Thus, the pharmacodynamics of the drug is characterized by a combination of several directions: neurosensory modulation (potassium nitrate), remineralization of hard tissues (sodium fluoride), antimicrobial and antioxidant action (xylitol and herbal extracts), modulation of inflammatory processes, and support of local homeostasis (aloe vera, chamomile, sage, eucalyptus). The level of action is predominantly local, tissue-specific, involving the nervous, immune, and epithelial systems at the peripheral level.

References: PubMed, PMID: 28410940; PMC: PMC7371031; ScienceDirect, DOI: 10.1016/j.jdent.2018.05.014; SpringerLink, DOI: 10.1007/s40123-020-00269-5; WHO Oral Health Fact Sheet, 2020.

Pharmacokinetics of Toothpaste for Sensitive Teeth (Ultra Sensitive Toothpaste)

The pharmacokinetic features of this drug are determined by the route of administration — topical application to the oral mucous membranes with limited potential for systemic absorption. The main action is realized locally through direct contact of active substances with the hard tissues of the tooth, gums, and oral microbiota.

Inorganic components, such as nitrate salts and fluorine-containing compounds, have a limited ability for trans membrane diffusion through the mucous membrane. Accidental swallowing may lead to partial absorption in the gastrointestinal tract with subsequent involvement of the liver and kidneys in metabolism and excretion. The main routes of excretion are renal clearance and partially biliary excretion.

Organic humectants and polysaccharide structures are distributed locally, forming a protective hydrophilic film on the mucosal surface. Their absorption through the epithelium is minimal; most are removed with the residue of the paste after rinsing.

Phytochemical compounds (flavonoids, terpenoids, essential oils) have the ability to be partially absorbed through the oral mucosa. Polyphenols undergo metabolism by microflora with the formation of biologically active metabolites that can influence local enzyme systems and antioxidant defense. If swallowed, herbal extracts undergo primary metabolism in the liver and further excretion predominantly in urine.

Thus, the pharmacokinetic profile of the drug is characterized by local exposure of active substances with limited systemic absorption. Key metabolic pathways include microbiological transformation of polyphenols, hepatic metabolism of organic compounds, and renal excretion of water-soluble components.

References: PubMed PMID: 34123974; PMC: PMC8159893; ScienceDirect DOI: 10.1016/j.jdent.2018.05.014; SpringerLink DOI: 10.1007/s40123-020-00269-5.

Mechanisms of Action and Scientific Rationale: Toothpaste for Sensitive Teeth (Ultra Sensitive Toothpaste)

Liver and Gastrointestinal Tract. Fluorine-containing compounds and polyphenols of plant origin have a modulating effect on remineralization processes and the metabolic activity of the microbiocenosis. Flavonoids and terpenoids can bind free radicals, exerting antioxidant and membrane-stabilizing effects, reducing lipid peroxidation in cell membranes. Additionally, they regulate the activity of liver enzyme systems, including CYP450, and may enhance choleretic processes, which is associated with lipotropic and detoxifying effects.
References: PubMed PMID: 32914392; ScienceDirect DOI: 10.1016/j.phymed.2020.153286.

Immune System. Herbal extracts of chamomile, sage, and aloe vera modulate the immune response by regulating cytokine production, inhibiting NF-κB and MAPK cascades, which reduces the activity of pro-inflammatory mediators (TNF-α, IL-6, IL-1β). Essential oils of eucalyptus and clove demonstrate additive antimicrobial action, affecting microbial cell walls and stimulating the activation of macrophage phagocytic activity. The combination of components provides a potentiating immunomodulatory effect at the local level of the mucous membrane.
References: SpringerLink DOI: 10.1007/s11418-019-01373-7; Wiley DOI: 10.1002/ptr.6624.

Nervous System. Potassium nitrate reduces the excitability of nerve endings in dentinal tubules by stabilizing the membrane potential, leading to reduced sensitivity to mechanical and thermal irritants. This mechanism is realized at the level of peripheral nerve fibers and is not accompanied by a systemic effect on the central nervous system. An additional protective effect is provided by the modulating influence of antioxidants, which prevent the neurotoxic action of free radicals.
Reference: PubMed PMID: 27693886; PMC: PMC6616754.

Endocrine and Metabolic Regulation. Green tea and cinnamon polyphenols influence cellular signaling cascades JAK/STAT and PI3K/Akt, which is associated with a modulating effect on cellular metabolism processes and endothelial function. These mechanisms contribute to the optimization of local energy metabolism in oral tissues and the reduction of oxidative stress. The action is system-modulating and cell-tissue in nature, with elements of additive interaction between flavonoids and terpenoid compounds.
References: Taylor & Francis DOI: 10.1080/10408398.2020.1779021; PMC: PMC8743248.