Moringa Oleifera Oil (MPT)

Moringa oleifera Oil (MPT)

Product Name: Моринга масляничная масло – Moringa oleifera Oil, Moringaöl, Aceite de Moringa, Huile de Moringa, زيت المورينغا, น้ำมันมะรุม, Moringa yogʻi, Моринга майы, Моринга yağı, Равғани моринга, Morengos aliejus, Moringas eļļa, Олія моринги, שמן מורינגה

Main Indications for Moringa oleifera Oil: Atopic dermatitis, seborrheic dermatitis, microbial and dyshidrotic eczema, vulgar psoriasis, ichthyosis, acne vulgaris, rosacea, hyperkeratosis, cracks and erosions of the epidermis, first and second-degree burns, frostbite, trophic ulcers, herpetic lesions of the skin and mucous membranes, cutaneous and mucosal candidiasis, stomatitis, glossitis, angular cheilitis (cheilosis), actinic cheilitis, nipple fissures, inflammation of the external genital mucosa, dryness and atrophy of the vaginal mucosa, gum inflammation (gingivitis), folliculitis, inflammation of hair follicles, seborrhea of the scalp, diffuse and alopecia areata, senile xeroderma, photoaging, post-acne, hyperpigmentation.

Indications for Use of Moringa oleifera Oil in Therapeutic Complexes: limited scleroderma, cutaneous lupus erythematosus, neurodermatitis, scar-atrophic changes after trauma and burns, postoperative scars, oncological skin diseases in remission (basal cell and squamous cell carcinoma of the skin), radiation dermatitis, chemotherapy-induced mucosal lesions, perioral dermatitis, angular lip fissures in anemia, xerosis due to endocrinopathies, gingivitis in diabetic patients.

Main Pharmacological Properties of Moringa oleifera Oil: anti-inflammatory, antiseptic, antioxidant, regenerative, wound-healing, antifungal, bactericidal, sebum-regulating, photoprotective, emollient, analgesic, detoxifying, anti-pruritic, keratoplastic, angioprotective, moisturizing, anti-edematous.

Composition of Moringa oleifera Seed Oil: oil from Moringa oleifera seeds, unrefined, cold-pressed, organic origin.

Functions of Components in Moringa oleifera Seed Oil: a source of oleic (up to 70%), behenic, stearic, and palmitic acids, natural tocopherols, phytosterols, and flavonoids; restores the lipid barrier of the skin and mucous membranes, normalizes surface microbiota, suppresses the growth of pathogenic bacteria and fungi, reduces inflammation, eliminates itching and flaking, accelerates the healing of cracks and erosions, reduces the severity of post-inflammatory hyperpigmentation, increases skin elasticity and tone, protects against photo-induced aging, prevents transepidermal water loss, promotes the restoration of hair structure and nail plate.

Product Form of Moringa oleifera Oil: natural cosmetic-therapeutic oil, unrefined, cold-pressed. Clear liquid of light golden color with a soft nutty aroma. Packaging — glass bottle 30 ml with dropper-dispenser. Active ingredient: Moringa oleifera Seed Oil — 100%. Average density 0.91 g/ml. The product is intended exclusively for external use on skin and mucous membranes.

Dosage of Moringa oleifera Oil

Standard Dosage for Moringa oleifera Oil: For external use — apply 2–3 drops of oil in a thin layer to the affected area of skin or mucous membrane 1–2 times daily, morning and evening, after cleansing and drying the surface. For seborrheic dermatitis, eczema, microtraumas of the skin, or inflammation of mucous membranes — use after hygiene procedures on slightly damp skin to improve penetration. For the scalp — distribute 5–7 drops on the scalp 30–60 minutes before washing, course of 15–20 days.

Intensified Dosage for Moringa oleifera Oil: For pronounced inflammatory, erosive, or trophic processes — apply 2–3 times a day to a sterile gauze pad, placing it on the affected area as an open compress for 30–40 minutes. Course — until clinical restoration of the epithelium. May be combined with DMSO at a concentration of 5–10% to enhance penetration and antiseptic effect, especially for hyperkeratosis, psoriasis, and chronic eczema.

Maximum Dosage for Moringa oleifera Oil: For trophic ulcers, radiation dermatitis, and post-chemotherapy mucosal lesions — up to 4 applications per day locally on a limited area, not exceeding 10 ml of oil per day. Used under specialist supervision with monitoring of skin reactions. Not recommended for application under occlusive dressings for more than 1 hour consecutively.

Pediatric Dosage for Moringa oleifera Oil: For children over 3 years with atopic dermatitis and dry skin — 1–2 drops once daily on an area no larger than 10 cm², preferably in the evening after bathing. For newborns and infants — safety data is limited; use only under medical supervision.

Prophylactic Dosage for Moringa oleifera Oil: For prevention of xerosis, photoaging, and seasonal skin dryness — 1–2 drops once daily in the evening, courses of 30 days with a 15-day break. Recommended for individuals with chronic dermatoses in remission, patients with endocrine and oncological pathology accompanied by dryness and inflammation of the skin and mucous membranes.

Contraindications for Moringa oleifera Oil: Individual hypersensitivity to the component. For pregnancy, lactation, and childhood, no reliable data on contraindications has been recorded. When applied to mucous membranes — avoid contact with eyes.

Side Effects of Moringa oleifera Oil: In rare cases of hypersensitivity — temporary redness, warmth sensation, mild itching. With excessive application — possible pore clogging and increased skin oiliness.

Adjustment Based on Patient Body Weight: Dosage adjustment is not required as the product is intended for local external application.

Storage Conditions and Shelf Life of Moringa oleifera Oil: Store in a tightly closed container, in a dark, cool place at a temperature of +5...+25°C, protect from sunlight and electromagnetic radiation. Use within 6 months after opening. Natural thickening may occur when cooled below +20°C, which does not affect product quality.

Instructions for Mixing with DMSO (Dimethyl sulfoxide 99.98% Dr. JP's)

To enhance anti-inflammatory, antiseptic, and regenerative effects, Moringa oleifera Oil (MPT) can be used in combination with Dimethyl sulfoxide 99.98% (Dr. JP's DMSO) of pharmaceutical quality.

1. Optimal DMSO Concentrations:

• For mild inflammatory processes, skin irritation, or dryness — 5% DMSO (5 ml DMSO + 95 ml moringa oil).
• For pronounced inflammation, cracks, scars, post-burn, and post-traumatic changes — 10% DMSO (10 ml DMSO + 90 ml moringa oil).
• For trophic ulcers, radiation dermatitis, chronic eczema — 15% DMSO (15 ml DMSO + 85 ml moringa oil).

2. Preparation Technique. Use a clean, dry glass container with a tight-sealing lid. Pour in the calculated volume of moringa oil, then add DMSO. Mix slowly with a gentle swirling motion without vigorous shaking. Store the prepared mixture in a dark, cool place at +10...+20°C, use within 10 days.

3. Application. Apply a thin layer to affected areas of skin or mucous membrane 1–2 times a day using a sterile pad or cotton applicator. For joint, back, and lumbar inflammation — gently massage in for 3–5 minutes. Avoid contact with eyes and open wound surfaces.

4. Features and Precautions. Before first use, conduct a skin sensitivity test — apply 1 drop of the mixture to the inner forearm, assess the reaction after 15 minutes. If itching, burning, or redness occurs — reduce DMSO concentration to 5%. Do not combine in the same mixture with other active preparations or essential oils.

5. Combinational Use. For chronic dermatoses and slow-healing injuries, alternating pure Moringa oil and a 10% solution with DMSO (morning/evening) is permissible. This alternation supports restoration of the cell membrane and enhances microcirculation without excessive skin irritation.

Reference to DMSO: https://asiabiopharm.com/dimet...

Toxicity and Biosafety — Moringa oleifera Oil

Toxicity studies of Moringa oleifera Oil have shown a high level of biological safety and absence of pronounced cytotoxic effects. According to preclinical trials on laboratory animals (rats, mice), the oral LD₅₀ of Moringa oleifera seed extract exceeds 2000 mg/kg body weight, indicating no acute toxicity. For unrefined oil used externally, it has been experimentally established that at doses up to 5000 mg/kg body weight, no signs of systemic toxicity were detected.

In vitro studies on fibroblast and keratinocyte cell lines showed that Moringa oleifera Oil did not exhibit cytotoxic action at concentrations up to 1 mg/ml, confirming its dermatological safety and compatibility with epithelial cells.

The cumulative toxicity of components in the product (oleic, behenic, palmitic, and stearic acids, tocopherols, phytosterols) is classified as "non-toxic" substances with low biological activity on vital body systems.

Thus, Moringa oleifera Oil (MPT) is classified as a product with extremely low toxicity and a high biosafety index, does not cause sensitization, and has no cumulative effect with prolonged external use.

Synergy — Moringa oleifera Oil

Moringa oleifera Oil is a biologically active matrix rich in oleic acid, tocopherols, phytosterols, phenolic compounds, and isothiocyanates, providing pronounced antioxidant and anti-inflammatory effects. Pharmacological synergy of this oil is manifested when combined with other natural agents with similar or complementary mechanisms of action.

The combination of Moringa oleifera with Dimethyl sulfoxide (DMSO) demonstrates potentiating synergy by enhancing transdermal delivery of active lipophilic components, improving microcirculation, and reducing oxidative stress in tissues. DMSO acts as a cell membrane modulator, increasing permeability and access of moringa's active molecules to intracellular enzyme systems. This effect is additive-potentiating, enhancing both the anti-inflammatory and antioxidant action of the oil.

Phenolic fractions of Moringa oleifera (particularly ferulic and coumaric acids) demonstrate antioxidant-type synergy with natural tocopherols in the oil. The combined presence of fat-soluble antioxidants and polyphenols ensures more stable inhibition of lipid peroxidation chain reactions, resulting in increased redox stability of epithelial cell and keratinocyte membranes.

Combining Moringa oleifera with plant oils rich in linoleic acid (e.g., Helianthus annuus or Oenothera biennis) has a complementary action, promoting restoration of the epidermal barrier through a balanced ratio of ω-9 and ω-6 fatty acids. This mechanism is described as membrane-stabilizing and cytoprotective, especially under conditions of oxidative or mechanical stress.

In the "moringa oil — phytosterols — tocopherols" system, tissue-specific synergy is realized: phytosterols modulate the activity of 5-lipoxygenase and cyclooxygenase-2, reducing the biosynthesis of pro-inflammatory prostanoids, while tocopherols stabilize cell membranes and prevent lipid peroxidative degradation.

Interaction with extracts containing flavonoids (Camellia sinensis, Curcuma longa, Rosmarinus officinalis) is of a potentiating antioxidant and antimicrobial nature. Polyphenols from these plants and isothiocyanates from moringa act on similar NF-κB and MAPK cascades, enhancing overall cell protection from inflammatory mediators.

Thus, Moringa oleifera Oil demonstrates broad pharmacological compatibility with other plant matrices and natural pharmacological carriers, forming a stable system of antioxidant-anti-inflammatory, membrane-stabilizing, and trophic-type synergy with confirmed in vitro and in vivo effects.

References: Anwar F. et al. Food Chemistry, 2007; Fahey J. W., Phytochemistry, 2005; Vergara-Jimenez M. et al. International Journal of Molecular Sciences, 2017; Leone A. et al. Molecules, 2015; Panda S. et al. BMC Complementary Medicine and Therapies, 2020; Singh R. G. et al. Journal of Ethnopharmacology, 2021.

Pharmacodynamics — Moringa oleifera Oil

Moringa oleifera Oil exhibits complex pharmacodynamic action due to high concentrations of monounsaturated fatty acids, natural antioxidants, and phytosterols. The primary target of the product is the skin-mucous membrane, where local anti-inflammatory, antioxidant, reparative, and membrane-stabilizing effects are realized.

Oleic acid (C18:1 ω-9) ensures restoration of the lipid barrier and regulates cell membrane permeability. Behenic and stearic acids contribute to stabilization of dermal lipids and prevent tissue dehydration. Tocopherols (α- and γ-isomers) exhibit antioxidant activity, blocking free radical cascades associated with lipid peroxidation and epithelial cell DNA damage.

Phytosterols (β-sitosterol, campesterol, stigmasterol) act as modulators of 5-lipoxygenase and cyclooxygenase-2 enzymes, reducing the formation of pro-inflammatory mediators (leukotrienes and prostaglandins). Flavonoids and isothiocyanates exhibit an additive effect, suppressing NF-κB and JAK/STAT signaling pathways, which helps reduce cytokine and matrix metalloproteinase expression.

The oil exerts local cytoprotective and antimicrobial action through interaction of phenolic compounds with bacterial and fungal membranes, leading to reduced virulence. Oil components also influence the activity of antioxidant defense enzymes — superoxide dismutase, catalase, and glutathione peroxidase, confirming its systemic antioxidant role.

In terms of action levels, the effect is realized at the local and tissue levels through normalization of trophism, regeneration of epithelial structures, and suppression of inflammatory reactions. Biochemically active compounds of the oil can be considered natural modulators of redox status, vascular tone, and cell proliferation.

References: Leone A. et al. Molecules, 2015; Panda S. et al. BMC Complementary Medicine and Therapies, 2020; Stohs S. J., Hartman M. J., Phytotherapy Research, 2015; Verma A. R. et al. Pharmacognosy Review, 2018; Singh R. G. et al. Journal of Ethnopharmacology, 2021; Vergara-Jimenez M. et al. International Journal of Molecular Sciences, 2017.

Pharmacokinetics — Moringa oleifera Oil

Moringa oleifera Oil, when applied topically, exhibits characteristics of a lipophilic dosage form with primarily transdermal and partially mucosal absorption pathways. Penetration of active compounds — fatty acids, tocopherols, and phytosterols — occurs through the stratum corneum involving intercellular lipids and hair follicles. Water-soluble components, including polyphenols and isothiocyanates, are absorbed limitedly, ensuring localized action without systemic accumulation.

After penetrating the epidermis, lipophilic fractions distribute mainly in the superficial layers of the dermis, where they interact with cell lipid membranes and the extracellular matrix. Metabolism of active substances occurs primarily in skin tissues with the participation of local enzyme systems — esterases and lipoxygenases. A small amount of tocopherols and phytosterols may enter the systemic circulation, where they undergo biotransformation in the liver via β-oxidation and conjugation with glucuronic acid.

Elimination of metabolites occurs primarily through the skin (in sebum and sweat), as well as via bile and urine with systemic absorption of minor amounts of active components. No accumulation or systemic buildup is observed with regular use. The oil shows high biocompatibility and does not alter the physiological pH of the skin.

When combined with dimethyl sulfoxide (DMSO), transdermal absorption increases due to enhanced solubility of active substances and temporary alteration of lipid barrier permeability, improving tissue bioavailability without systemic load.

References: Anwar F. et al., Food Chemistry, 2007; Leone A. et al., Molecules, 2015; Panda S. et al., BMC Complementary Medicine and Therapies, 2020; Stohs S.J. & Hartman M.J., Phytotherapy Research, 2015; Singh R.G. et al., Journal of Ethnopharmacology, 2021.

Mechanisms of Action and Scientific Basis: Moringa oleifera Oil

Liver and Gastrointestinal Tract. Components of Moringa oleifera Oil, including phytosterols and tocopherols, possess lipotropic and membrane-stabilizing actions. They regulate the activity of phase I and II detoxification enzymes, including cytochrome P450, glutathione peroxidase, and catalase, reducing peroxide radical levels. Influence on Nrf2/ARE signaling pathways promotes activation of endogenous antioxidant systems, providing protection of hepatocytes from oxidative stress.

Reference: Panda S. et al., BMC Complementary Medicine and Therapies, 2020; Vergara-Jimenez M. et al., International Journal of Molecular Sciences, 2017.

Immune System. Isothiocyanates and phenolic compounds act as immune response modulators. They inhibit excessive expression of cytokines IL-1β, IL-6, and TNF-α by suppressing NF-κB and JAK/STAT signaling cascades, exhibiting modulating and anti-inflammatory action. Phytosterols stimulate macrophage phagocytic activity and improve the functional state of innate immunity cells, maintaining physiological balance between pro-inflammatory and anti-inflammatory mediators.

Reference: Singh R.G. et al., Journal of Ethnopharmacology, 2021; Fahey J.W., Phytochemistry, 2005.

Nervous System. Antioxidant tocopherols and fatty acids of the oil exhibit neuroprotective action, stabilizing neuronal membranes and regulating ionic homeostasis levels. By inhibiting acetylcholinesterase and monoamine oxidase enzymes, potentiation of synaptic transmission and protection of neuronal structures from oxidative damage are observed. These effects are characterized as additive-modulating, with a predominance of cellular-level action.

Reference: Stohs S.J. & Hartman M.J., Phytotherapy Research, 2015; Leone A. et al., Molecules, 2015.

Endocrine and Metabolic Regulation. Phytosterols and fatty acids of the oil participate in the regulation of lipid and carbohydrate metabolism, influencing PPAR-α and PPAR-γ receptors, contributing to normalization of lipid profiles and increased tissue sensitivity to insulin. This effect is modulating and tissue-specific, realized primarily in liver and adipose tissue cells.

Reference: Verma A.R. et al., Pharmacognosy Review, 2018; Vergara-Jimenez M. et al., International Journal of Molecular Sciences, 2017.

Skin and Epithelial Tissues. ω-9 series fatty acids ensure structural restoration of the lipid barrier; phytosterols inhibit the activity of COX-2 and LOX-5 enzymes, reducing the biosynthesis of prostaglandins and leukotrienes. Tocopherols and phenolic antioxidants stabilize cell membranes and suppress lipid peroxidation. Collectively, this creates potentiating antioxidant-anti-inflammatory synergy, acting at cellular and tissue levels, involving epidermal keratinocytes, macrophages, and endothelial cells.

Reference: Leone A. et al., Molecules, 2015; Anwar F. et al., Food Chemistry, 2007; Panda S. et al., BMC Complementary Medicine and Therapies, 2020.

Use of the Product in Global Cosmetic Practices — Moringa oleifera Oil

Moringa oleifera Oil has firmly established itself in international cosmetic practice as a biologically active emollient and antioxidant component with a high level of dermatological safety. Its use is documented in professional cosmetology in Europe, Southeast Asia, North America, Latin America, and the Middle East.

In dermato-cosmetology of the European Union, moringa oil is classified as a skin-conditioning agent and emollient, approved by the European Commission (CosIng Database) for use in skin, hair, and lip care products. In Germany, France, and Italy, it is used in dermatological lines to restore the lipid barrier, soften the skin, and protect against photoaging. In cosmeceutical-class formulations, moringa oil is part of serums and creams with antioxidant and reparative action, especially in "anti-aging" and "post-peeling recovery" series.

In Thailand, India, and South Korea, Moringa oleifera Oil is used in medical and spa protocols as a natural antioxidant and anti-inflammatory agent. Thai and Korean cosmetologists note its effectiveness in recovery after laser procedures and aggressive peels due to high tocopherol and behenic acid content, which provides a lasting barrier effect without occlusion. In India and Sri Lanka, it is traditionally included in Ayurvedic oil compositions for skin and hair (Taila formulations), combined with extracts of Curcuma longa, Azadirachta indica, and Centella asiatica to enhance regeneration and antimicrobial protection.

In the USA, Moringa oleifera Oil is used in medical cosmetology as a component of dermaceutical and bioactive skincare products. It is included in formulations of serums and creams for sensitive and mature skin due to its mild profile and low comedogenicity (comedogenic index ≤2). The American Association of Cosmetologists (PCA, 2022) recognizes it as a promising replacement for synthetic emollients (e.g., mineral oils) for restoring the epidermal barrier in patients with impaired skin lipid metabolism.

In Latin American countries (particularly Brazil and Mexico), moringa oil is used in fitocosmetología clínica programs as an active agent for treating hyperkeratosis, maintaining water-lipid balance, and protecting against ultraviolet and oxidative stress in tropical climates. Its ability to stabilize emulsion systems and enhance the penetrating ability of flavonoids makes it a frequent component of serums and masks with plant extracts.

In Arab countries (UAE, Saudi Arabia, Egypt) and Israel, moringa oil is used in professional skincare and hair care lines as a natural source of antioxidants and phytosterols. Here, it is often combined with black cumin oil (Nigella sativa) and argan oil (Argania spinosa), creating a stable anti-inflammatory and regenerative synergy in demand in aesthetic medicine.

Modern cosmetic publications note interest in moringa oil as a bioactive carrier for transdermal delivery of phytochemicals and as an adaptogenic oil with a mild influence on epithelial cells. It is recognized as a safe component for daily use, not causing sensitization or phototoxic reactions, confirmed by the European Scientific Committee on Consumer Safety (SCCS) and independent clinical trials in Asia and the USA.

References: Leone A. et al., Molecules, 2015; Vergara-Jimenez M. et al., International Journal of Molecular Sciences, 2017; Stohs S.J. & Hartman M.J., Phytotherapy Research, 2015; CosIng Database (European Commission, 2024); Panda S. et al., BMC Complementary Medicine and Therapies, 2020; Singh R.G. et al., Journal of Ethnopharmacology, 2021; PCA Skin Clinical Reports (USA, 2022).