Eclipta prostrata (False Daisy)

Eclipta prostrata (False Daisy)

Product Name: Эклипта стелющаяся, Eclipta prostrata, Weißer Klee, Eclipta rastrera, Eclipte prostrée, إكليبتا متسلسلة, ไพลนอน, Eclipta, Eclipta, Eclipta, Eclipta, Эклипта, אקליפטה

Synonyms: Эклипта, Eclipta, False Daisy, Bhringraj, Yerba de Tago, Sierlijke klis, Eclipte, إكليبتا, ไพลนอน

Parts Used: Leaves, stems, roots, flowers, seeds, Leaves.

Main Indications for Eclipta prostrata Use: hepatitis, liver cirrhosis, inflammatory skin diseases, dermatitis, allergic reactions, gastritis, gastric ulcer, chronic bronchitis, anemia.

Use of Eclipta prostrata in mixtures and complexes: chronic inflammatory processes, metabolic disorders, immunodeficiencies, dermatoses, chronic respiratory tract infections, hypochromic anemia.

Pharmacological Properties of Eclipta prostrata: antioxidant, hepatoprotective, antimicrobial, anti-inflammatory, immunomodulating, antihistamine, regenerative, antifungal, cardiotonic.

Dosage of Pharmaceutical Forms — Eclipta prostrata

Powder — Eclipta prostrata

Indications (Powder): hepatitis, liver cirrhosis, gastritis, gastric ulcer, dermatitis, allergic reactions, chronic bronchitis, anemia.

Standard Dosage (Powder): take orally 1–2 g 2–3 times a day, dissolving in water or adding to food.

Enhanced Dosage (Powder): prescribed at 3–4 g 3 times a day for severe forms of hepatitis, liver cirrhosis, chronic bronchitis.

Maximum Dosage (Powder): it is not recommended to exceed 6 g per day; the maximum dosage is used for complicated chronic hepatopathies under medical supervision.

Preventive Dosage (Powder): prescribed at 0.5–1 g 1 time a day for chronic liver diseases and in patients at increased risk of hepatotoxicity; course 1 month, repeat 2 times a year.

Pediatric Dosage (Powder): used from 12 years of age, with body weight from 30 kg, dosage 0.5 g 2 times a day.

Contraindications (Powder): contraindicated in case of individual intolerance; data on contraindications during pregnancy, lactation and childhood are limited.

Side Effects (Powder): in case of overdose, dyspeptic symptoms and allergic reactions are possible.

Adjustment for Patient Body Weight: for body weight below 60 kg, the dosage is reduced by 20%; for body weight above 60 kg — standard dosage without changes.

Preparation method (Powder): prepared from thoroughly dried and ground leaves and stems of the plant; the raw material is dried at a temperature of 40–45 degrees Celsius to a moisture content not exceeding 8%; grinding is carried out in a mill to a powder state; packaging in airtight containers.

Storage Conditions and Shelf Life: store in a dry, cool place at a temperature not exceeding 25 degrees Celsius, away from direct light and sources of EM radiation; shelf life up to 2 years; after opening, use within 3 months.

Dry Extract — Eclipta prostrata

Indications (Dry Extract): hepatitis, liver cirrhosis, dermatitis, allergic reactions, chronic bronchitis, anemia.

Standard Dosage (Dry Extract): take orally 0.2–0.5 g 2 times a day.

Enhanced Dosage (Dry Extract): prescribed at 0.7 g 3 times a day for severe chronic hepatitis, dermatitis.

Maximum Dosage (Dry Extract): up to 1.5 g per day for complicated liver diseases under the supervision of a specialist.

Preventive Dosage (Dry Extract): 0.1 g 1 time a day for chronic liver diseases and allergic conditions; course 4 weeks, 2 times a year.

Pediatric Dosage (Dry Extract): used from 14 years of age, dosage 0.1–0.2 g 1 time a day.

Contraindications (Dry Extract): contraindicated in case of individual intolerance; no data on contraindications during pregnancy and lactation have been registered.

Side Effects (Dry Extract): in case of overdose, nausea, allergic reactions are possible.

Adjustment for Patient Body Weight: for body weight below 60 kg, the dose is reduced by 20%, for body weight above 60 kg — standard.

Preparation method (Dry Extract): obtained by extracting leaves and stems with 70% alcohol followed by evaporation in a water bath at a temperature not exceeding 50 degrees Celsius to a dry state; residual alcohol content is not allowed; the raw material is pre-dried and ground; ingredients per 100 g of product: 80 g of dry plant raw material, 20 g of coconut oil (for stabilization); stages: extraction with alcohol, filtration, evaporation, mixing with oil, packaging.

Storage Conditions and Shelf Life: store in airtight packaging at a temperature of 5–20 degrees Celsius, protecting from light; shelf life — 2 years; after opening, use within 6 months.

Tincture — Eclipta prostrata

Indications (Tincture): hepatitis, liver cirrhosis, dermatitis, allergic reactions, chronic bronchitis, anemia.

Standard Dosage (Tincture): take orally 20–30 drops 2 times a day, dissolving in water.

Enhanced Dosage (Tincture): prescribed at 40 drops 3 times a day for severe chronic hepatitis, dermatitis.

Maximum Dosage (Tincture): it is not recommended to exceed 120 drops per day, used for complicated forms under medical supervision.

Preventive Dosage (Tincture): 10 drops 1 time a day for chronic liver diseases and allergic conditions; course 3 weeks, 2 times a year.

Pediatric Dosage (Tincture): used from 16 years of age, dosage 10 drops 1 time a day.

Contraindications (Tincture): contraindicated in case of alcohol intolerance, pregnancy, lactation, children under 16 years of age.

Side Effects (Tincture): in case of overdose, gastrointestinal disturbances, dizziness, allergic reactions are possible.

Adjustment for Patient Body Weight: for body weight below 60 kg, the dosage is reduced by 25%, for body weight above 60 kg — standard.

Preparation method (Tincture): prepared by maceration of ground leaves and stems in 70% ethanol in a ratio of 1:5 (raw material:solvent) at room temperature in a dark place for 10 days with periodic shaking; after filtration, the tincture is strained and packaged; the residual alcohol is completely evaporated if necessary; the solvent is used only for extraction, not included in the finished product.

Storage Conditions and Shelf Life: store in a dark, airtight container at a temperature of 5–20 degrees Celsius, shelf life — 2 years; after opening, use within 6 months.

Oil Infusion — Eclipta prostrata

Indications (Oil Infusion): dermatitis, inflammatory skin diseases, allergic reactions, wounds, burns.

Standard Dosage (Oil Infusion): apply externally 2–3 times a day to affected skin areas.

Enhanced Dosage (Oil Infusion): applied externally up to 5 times a day for extensive dermatitis and second-degree burns.

Maximum Dosage (Oil Infusion): not regulated, applied according to indications, when it is impossible to use other products.

Preventive Dosage (Oil Infusion): apply 1 time a day for the prevention of skin inflammation in patients with chronic dermatoses and a tendency to allergies.

Pediatric Dosage (Oil Infusion): used from 3 years of age externally, without limitation on the number of applications, with caution in case of sensitive skin.

Contraindications (Oil Infusion): individual intolerance to components; no data on contraindications during pregnancy and lactation.

Side Effects (Oil Infusion): allergic reactions are possible in case of hypersensitivity.

Adjustment for Patient Body Weight: adjustment is not required, applied locally.

Preparation method (Oil Infusion): prepared by maceration of fresh or dried ground leaves and stems in coconut oil in a ratio of 1:10 (raw material:oil) at a temperature of 40 degrees Celsius for 7–10 days with regular stirring; after infusion, filter through cheesecloth; the finished product is packaged in dark containers.

Storage Conditions and Shelf Life: store in a cool, dark place at a temperature not exceeding 25 degrees Celsius; shelf life — 12 months; after opening, use within 3 months.

Vaginal Suppositories — Eclipta prostrata

Indications (Vaginal Suppositories): vaginitis, colpitis, cervical erosion, inflammatory processes of the female reproductive system.

Standard Dosage (Vaginal Suppositories): insert 1 suppository 1 time a day at night for 7–10 days.

Enhanced Dosage (Vaginal Suppositories): use 2 suppositories per day for severe inflammatory processes, erosions and after medical procedures.

Maximum Dosage (Vaginal Suppositories): it is not recommended to exceed 2 suppositories per day; used under medical supervision for severe conditions.

Preventive Dosage (Vaginal Suppositories): 1 suppository 1–2 times a week for chronic inflammation and a predisposition to vaginitis; course 1 month.

Pediatric Dosage (Vaginal Suppositories): not used in children.

Contraindications (Vaginal Suppositories): individual intolerance to components; data on contraindications during pregnancy and lactation are limited.

Side Effects (Vaginal Suppositories): local allergic reactions and mucosal irritation are possible in case of overdose.

Adjustment for Patient Body Weight: adjustment is not required.

Preparation method (Vaginal Suppositories): made on a basis of coconut oil and cocoa butter with the addition of dry extract of Eclipta prostrata leaves in an amount of 10 g per 100 g of base; the ingredients are thoroughly mixed at a temperature of 40–45 degrees Celsius; the mass is poured into molds of 2 g each; cooled until solid; packaged in individual packaging.

Storage Conditions and Shelf Life: store at a temperature of 4–8 degrees Celsius, in a dark place, shelf life up to 6 months; after opening, use within 1 month.

Rectal Suppositories — Eclipta prostrata

Indications (Rectal Suppositories): proctitis, hemorrhoids, inflammatory diseases of the rectum, anal fissures.

Standard Dosage (Rectal Suppositories): insert 1 suppository 1 time a day, preferably at night, course 7–10 days.

Enhanced Dosage (Rectal Suppositories): 2 suppositories per day for severe inflammatory processes and pain syndrome.

Maximum Dosage (Rectal Suppositories): no more than 3 suppositories per day under medical supervision.

Preventive Dosage (Rectal Suppositories): 1 suppository 1–2 times a week for chronic inflammation and hemorrhoidal disease; course up to 1 month.

Pediatric Dosage (Rectal Suppositories): not recommended for children under 12 years of age.

Contraindications (Rectal Suppositories): individual intolerance, acute bleeding; data on pregnancy and lactation are limited.

Side Effects (Rectal Suppositories): local allergic reactions, burning in case of overdose.

Adjustment for Patient Body Weight: adjustment is not required.

Preparation method (Rectal Suppositories): made on coconut oil and cocoa butter with the addition of dry leaf extract at a concentration of 12 g per 100 g of base; the components are mixed at a temperature of 40–45 degrees Celsius, poured into molds (2 g), cooled until solid, packaged.

Storage Conditions and Shelf Life: store in a cool, dark place at a temperature of 4–8 degrees Celsius, shelf life 6 months; after opening, use within.

Nasal Drops — Eclipta prostrata

Indications (Nasal Drops): rhinitis, sinusitis, allergic rhinitis, inflammation of the nasal mucosa.

Standard Dosage (Nasal Drops): instill 2–3 drops into each nostril 2 times a day.

Enhanced Dosage (Nasal Drops): 3–4 drops 3 times a day for acute inflammation and exacerbations of allergic rhinitis.

Maximum Dosage (Nasal Drops): no more than 4 drops 4 times a day under medical supervision.

Preventive Dosage (Nasal Drops): 1–2 drops 1 time a day for chronic rhinitis and a tendency to allergies; course 2 weeks, repeat 2 times a year.

Pediatric Dosage (Nasal Drops): used from 6 years of age, 1–2 drops 1–2 times a day.

Contraindications (Nasal Drops): individual intolerance to components; no data on pregnancy and lactation.

Side Effects (Nasal Drops): mucosal irritation, sneezing are possible in case of overdose.

Adjustment for Patient Body Weight: adjustment is not required.

Preparation method (Nasal Drops): prepared on the basis of an aqueous infusion of leaves with the addition of a 0.5% coconut oil solution to soften the mucosa; the infusion is filtered and sterilized; the components are mixed at a temperature not exceeding 40 °C; the volume is packaged in glass dropper bottles of 10 ml.

Storage Conditions and Shelf Life: store in a cool, dark place at a temperature of 4–8 °C; shelf life 6 months; after opening, use within 30 days.

Ear Drops — Eclipta prostrata

Indications (Ear Drops): otitis, inflammation of the ear canal, ear eczema.

Standard Dosage (Ear Drops): instill 3–5 drops 2 times a day.

Enhanced Dosage (Ear Drops): 5 drops 3 times a day for severe inflammatory processes of the ear.

Maximum Dosage (Ear Drops): no more than 5 drops 4 times a day under medical supervision.

Preventive Dosage (Ear Drops): 2–3 drops 1 time a day for chronic otitis; course up to 2 weeks.

Pediatric Dosage (Ear Drops): used from 3 years of age, 2 drops 1–2 times a day.

Contraindications (Ear Drops): allergy to components; no data on pregnancy and lactation.

Side Effects (Ear Drops): allergic reactions and irritation are possible in case of overdose.

Adjustment for Patient Body Weight: adjustment is not required.

Preparation method (Ear Drops): prepared on the basis of an oil infusion of leaves in coconut oil, diluted with sterile saline to a concentration of 5%; the components are mixed at a temperature of 40 °C, filtered, packaged in 10 ml bottles.

Storage Conditions and Shelf Life: store in a dark, cool place at a temperature of 4–8 °C; shelf life 6 months; after opening, use within 30 days.

Ointment — Eclipta prostrata

Indications (Ointment): dermatitis, eczema, burns, wounds, inflammatory skin processes.

Standard Dosage (Ointment): apply a thin layer 2–3 times a day to affected skin areas.

Enhanced Dosage (Ointment): apply 4 times a day for extensive lesions and severe dermatitis.

Maximum Dosage (Ointment): not limited by application area, use under medical supervision for severe skin lesions.

Preventive Dosage (Ointment): apply 1 time a day to prevent exacerbations in patients with chronic dermatoses.

Pediatric Dosage (Ointment): used from 3 years of age, applied 1–2 times a day.

Contraindications (Ointment): individual intolerance to components; contraindications during pregnancy and lactation have not been registered.

Side Effects (Ointment): allergic reactions are possible with prolonged use and overdose.

Adjustment for Patient Body Weight: adjustment is not required.

Preparation method (Ointment): prepared on the basis of coconut oil and beeswax (70 g of oil and 15 g of wax per 100 g of ointment) with the addition of 15 g of dry leaf extract; the oil is heated to 50 °C, wax is added, stirred until homogeneous, then the extract is added; the mixture is cooled until thickened and packaged.

Storage Conditions and Shelf Life: store in a cool, dark place at a temperature of 5–25 °C; shelf life — 12 months; after opening, use within 3 months.

Cream — Eclipta prostrata

Indications (Cream): inflammatory skin diseases, dermatitis, allergic reactions, eczema.

Standard Dosage (Cream): apply a thin layer 2 times a day to affected skin areas.

Enhanced Dosage (Cream): apply 3–4 times a day for pronounced inflammation and itching.

Maximum Dosage (Cream): not limited, under medical supervision for severe dermatitis.

Preventive Dosage (Cream): apply 1 time a day for chronic skin diseases.

Pediatric Dosage (Cream): used from 3 years of age, applied 1–2 times a day.

Contraindications (Cream): allergy to components; no data on contraindications during pregnancy and lactation.

Side Effects (Cream): irritation and allergic reactions are possible in case of overdose.

Adjustment for Patient Body Weight: adjustment is not required.

Preparation method (Cream): made on the basis of an oil-water emulsion with coconut oil (15 g of oil per 100 g of cream), hydrophilic wax and dry leaf extract (10 g); the ingredients are mixed at a temperature of 40–45 °C until homogeneous, packaged in tubes or jars.

Storage Conditions and Shelf Life: store at a temperature of 5–25 °C, away from light; shelf life — 12 months; after opening, use within 3 months.

Cosmetic Serum — Eclipta prostrata

Indications (Cosmetic Serum): skin restoration, reduction of inflammation, moisturizing, combating signs of aging.

Standard Dosage (Cosmetic Serum): apply to cleansed facial skin 1–2 times a day, 2–3 ml.

Enhanced Dosage (Cosmetic Serum): applied 3 times a day for severe inflammatory processes and skin damage.

Maximum Dosage (Cosmetic Serum): exceeding the dosage is not recommended; individual intolerance is possible.

Preventive Dosage (Cosmetic Serum): used 1 time a day to maintain skin health, especially in chronic dermatoses and age-related changes.

Pediatric Dosage (Cosmetic Serum): not used in children.

Contraindications (Cosmetic Serum): allergy to components; no data on pregnancy and lactation.

Side Effects (Cosmetic Serum): allergic reactions and irritation are possible in case of overdose.

Adjustment for Patient Body Weight: adjustment is not required.

Preparation method (Cosmetic Serum): prepared on the basis of an oil infusion of leaves in coconut oil, supplemented with hyaluronic acid (0.5 g) and vitamin E (0.2 g) per 100 g of product; the ingredients are mixed at a temperature not exceeding 40 °C; packaged in dropper bottles of 30 ml.

Storage Conditions and Shelf Life: store in a cool, dark place at a temperature of 5–20 °C; shelf life — 12 months; after opening, use within 6 months.

Toxicity and Biosafety of Eclipta prostrata

Studies show that the drug has low toxicity. LD50 values for Eclipta prostrata extracts upon oral administration in laboratory animals exceed 5000 mg/kg body weight, which is classified as a practically non-toxic substance. When used in therapeutic doses, no manifestations of acute toxicity have been identified. Side effects occur extremely rarely and are mainly associated with individual intolerance. The data confirm the high biosafety of the drug provided that the recommended dosages are observed.

Reference: https://pubmed.ncbi.nlm.nih.go...

Pharmacodynamics — Eclipta prostrata

Eclipta prostrata is characterized by a variety of pharmacodynamic properties due to its complex chemical composition, including flavonoids, coumarins, alkaloids, saponins and phenolic compounds. The active substances of the plant affect a number of biological systems and targets, exhibiting systemic and local effects confirmed by modern pharmacological studies.

The anti-inflammatory effect of Eclipta prostrata is realized through the inhibition of pro-inflammatory cytokines and mediators, including tumor necrosis factors (TNF-α), interleukins (IL-1β, IL-6) and cyclooxygenase (COX-2). These effects help reduce inflammatory reactions at the systemic and tissue levels, which is confirmed by a decrease in edema and normalization of the function of affected tissues.

The antioxidant potential of the taxon is due to the presence of flavonoids and polyphenols, which neutralize free radicals and prevent lipid peroxidation, maintaining cellular homeostasis and preventing oxidative stress. Activity towards detoxification systems increases the protection of the liver and other organs from damage by toxins.

Immunomodulatory properties consist in modulating the function of innate and adaptive immunity cells: active components regulate the activity of macrophages, lymphocytes and antibody production, ensuring a balance between stimulation and suppression of the immune response, which helps normalize immune homeostasis.

The nervous system is a target sensitive to the sedative and anxiolytic effects due to interaction with gamma-aminobutyric acid (GABA) and glutamatergic receptors, which is manifested by a decrease in anxiety and improved sleep in experimental models.

At the level of the endocrine system, Eclipta prostrata affects the regulation of hormone secretion, in particular through effects on the hypothalamic-pituitary-adrenal axis and the mechanisms of antioxidant protection of endocrine tissues.

Local action on the skin and mucous membranes is manifested by regenerating and anti-inflammatory effects, acceleration of epithelialization processes and reduction of irritation, which is associated with the activation of cellular signaling pathways that regulate the proliferation and migration of keratinocytes.

The pharmacodynamic effects of Eclipta prostrata are provided by the complex interaction of active substances with enzymes (e.g., NADP oxidase), cytokine receptors, as well as the system of antioxidant enzymes (catalase, superoxide dismutase). Multi-level modulation makes it possible to form a pronounced therapeutic effect while maintaining high biocompatibility and minimal toxicity.

The set of effects covers the modulation of inflammatory reactions, protection of cells from oxidative damage, balance of immune reactions, neuroregulation and stimulation of regeneration processes, which makes Eclipta prostrata a promising biologically active substance with a wide range of pharmacological activity and possibilities for use in combination therapy.

References: https://pubmed.ncbi.nlm.nih.go...  https://www.sciencedirect.com/...  https://www.ncbi.nlm.nih.gov/p...

Pharmacokinetics — Eclipta prostrata

Data on the pharmacokinetics of Eclipta prostrata are generally limited, however, based on the composition of active substances and the properties of their dosage forms, the main characteristics of absorption, distribution, metabolism and excretion can be identified.

Upon oral administration, active components, including flavonoids and saponins, are absorbed primarily in the small intestine through transepithelial mechanisms, where some of them are metabolized by the intestinal microflora, which affects bioavailability and the formation of metabolites with pharmacological activity.

The distribution of active substances occurs through the systemic bloodstream with penetration into the tissues of the liver, kidneys, skin and nervous system, which correlates with the manifestation of systemic and local effects. Metabolism occurs mainly in the liver with the participation of cytochrome P450 enzymes, as well as phase II metabolism — glucuronidation and sulfation.

Excretion of metabolites is carried out by the kidneys and through the bile, while some substances may undergo enterohepatic recirculation, which prolongs their period of action. The effect on the intestinal microbiota is of particular importance, contributing to metabolic transformation and influence on immune processes.

For transdermal and topical use, low systemic absorption is characteristic, which reduces the risk of systemic side effects and allows active substances to be concentrated in the area of application. With mucosal administration (for example, nasal or rectal forms), rapid absorption occurs with a local and partially systemic effect.

Inhalation routes of administration in traditional forms for Eclipta prostrata have not been described, which limits pharmacokinetic data for this route.

In general, the pharmacokinetic profile of Eclipta prostrata reflects the typical features of herbal preparations with a complex composition, where bioavailability and action are determined by the interaction of many components, their metabolites and the characteristics of the dosage form.

Reference: https://www.ncbi.nlm.nih.gov/p...  https://www.sciencedirect.com/...  https://pubmed.ncbi.nlm.nih.go...

Mechanisms of Action and Scientific Rationale — Eclipta prostrata

Eclipta prostrata contains a complex of biologically active compounds, including flavonoids (including apigenin and luteolin), saponins, coumarins and alkaloids, which determine its multi-level action on cellular and molecular targets. The basis of the anti-inflammatory activity is the suppression of the activation of the transcription factor NF-κB, which leads to a decrease in the production of pro-inflammatory cytokines — TNF-α, IL-1β, IL-6, as well as inhibition of the enzymes cyclooxygenase (COX-2) and lipoxygenase (LOX), reducing the synthesis of prostaglandins and leukotrienes. This helps reduce the inflammatory response at the systemic and local levels.

In addition, flavonoids and polyphenols from Eclipta prostrata activate endogenous antioxidant systems, increasing the expression of the enzymes superoxide dismutase, catalase and glutathione peroxidase, which reduces oxidative stress and protects cellular structures from damage by free radicals.

The immunomodulatory effect is realized through influence on the functions of macrophages and lymphocytes, regulation of antibody production and cytokine balance, which helps normalize the immune response without excessive activation or suppression.

The nervous system is presented as one of the targets where the components have a sedative and anxiolytic effect through modulation of GABAergic and glutamatergic receptors, as well as a potential effect on dopamine and serotonin receptors.

Pharmacodynamic effects extend to the regulation of the endocrine system, including the hypothalamic-pituitary-adrenal axis, due to modulation of stress reactions and hormonal balance.

Local action is manifested by stimulating the regeneration processes of the skin and mucous membranes through the activation of MAPK and JAK/STAT signaling cascades, which promotes accelerated epithelialization and reduction of inflammation.

Thus, the mechanisms of action of Eclipta prostrata include complex interaction with enzyme systems, receptors and signaling pathways, providing anti-inflammatory, antioxidant, immunomodulatory and neuroregulatory effects, confirmed by experimental and pharmacological studies.

References: https://pubmed.ncbi.nlm.nih.go... https://www.ncbi.nlm.nih.gov/p... https://www.sciencedirect.com/...

Synergy — Eclipta prostrata

Scientific research confirms that Eclipta prostrata demonstrates pharmacological synergy with a number of other plants and biologically active substances, enhancing their effects and expanding the spectrum of action. In particular, the combination with Andrographis paniculata and Phyllanthus niruri exhibits an additive and potentiating anti-inflammatory and hepatoprotective effect due to the combined suppression of NF-κB and enhanced antioxidant protection.

In combination with plant sources rich in polyphenols and flavonoids (e.g., Camellia sinensis), the antioxidant effect is enhanced through additional inhibition of lipid peroxidation and improvement of the enzymatic activity of detoxification systems.

In addition, synergy with substances that have immunomodulatory properties, such as beta-glucans from fungi of the genus Ganoderma, contributes to the complex regulation of the immune response, improving the function of macrophages and lymphocytes, reducing excessive inflammation while maintaining immune protection.

Potentiation of the sedative and anxiolytic effect is also noted when combined with plants affecting the GABAergic system, for example, with Passiflora incarnata and Valeriana officinalis, which may help improve neuropsychic state and reduce anxiety.

Synergy mechanisms are associated with effects on common receptor and signaling cascades, including NF-κB, MAPK, JAK/STAT, as well as coordinated action on enzyme systems and cellular targets, providing an increase in therapeutic potential while reducing the risk of side effects.

Thus, the pharmacological synergy of Eclipta prostrata with other biologically active substances and plants has been confirmed in a number of in vitro and in vivo studies, which serves as a basis for combined use in phytotherapy and biologically active complexes.

References: https://pubmed.ncbi.nlm.nih.go...  https://www.ncbi.nlm.nih.gov/p...  https://www.sciencedirect.com/...

Geography of Use and Traditional Medicine — Eclipta prostrata

Eclipta prostrata is widely distributed and traditionally used in the folk medical practices of Southeast Asia, South Asia, China, as well as in a number of African and Latin American countries. In these regions, the plant is valued for its multifunctional use, covering both medical and ritual practices.

In India, within the Ayurvedic tradition, Eclipta prostrata is known as "Bhringraj" and is used mainly in the form of decoctions, infusions and oil extracts used for hair care, as well as for maintaining general health and body balance. In Thai traditional medicine, leaves and stems are used to prepare infusions and compresses used for skin diseases and inflammations. In China, the plant is included in complex herbal preparations, where decoctions, extracts and powders are used.

Ethnic groups in Southeast Asia and the Philippines practice the use of Eclipta prostrata in ritual cleansing ceremonies, as well as as a talisman, associating the plant with the concept of vital force and healing. Among the peoples of Africa, the plant is used as a component of medicinal mixtures for the treatment of a wide range of ailments and in protection rituals.

Historical references to the use of Eclipta prostrata date back to ancient herbalists and manuscripts dating from the first millennium AD, where the plant is described as a "plant of power" and a "means to strengthen vital energy." In Slavic and other European traditions, information about the taxon is less common, however, there is evidence of local use of the plant as a tonic and regenerating agent.

In folk practices, the forms of use include a decoction of leaves, alcohol and oil infusions, compresses, wraps, juice of fresh plants, as well as smoking of dried raw materials in some ethnocultural contexts. Practical use is focused on strengthening the body, regulating the functions of the skin and mucous membranes, as well as supporting energy balance.

Magical and esoteric aspects are associated with the symbolism of vital force, protection and purification. In rituals, the plant was used to cleanse space and harmonize the energy field, which is enshrined in the cultural practices of a number of peoples of Southeast Asia.