Bauhinia purpurea (Purple Orchid Tree / Butterfly Tree)

Bauhinia purpurea (Purple Orchid Tree / Butterfly Tree)

Product Name: Бауиния пурпурная, Bauhinia purpurea, Purpurfarbige Bauhinie, Bauhinia púrpura, Bauhinia pourpre, باوهينيا أرجوانية, ชงโค, Бауҳиния сирғали, Баухиния кызыл, Bənövşəyi bauhiniya, Баухиния арғувонӣ, Bauhinia purpurea, Purpurinė bauhinija, Purpura bauhinija, Бауїнія пурпурна, Bauhinia purpurea, בוהיניה סגולה

Synonyms: Баухиния лиловая, Purple orchid tree, Butterfly tree, Purple bauhinia, Lila Schmetterlingsbaum, Árbol de las orquídeas púrpuras, Árbol mariposa, Arbre aux orchidées pourpres, شجرة الأوركيد الأرجوانية, ชงโคสีม่วง

Used Parts: leaves, flowers, fruits, seeds, stems, bark, roots.

Main Indications for Bauhinia purpurea: chronic inflammatory liver diseases, non-alcoholic fatty liver disease, liver cirrhosis, type 2 diabetes mellitus, hyperglycemia, hyperlipidemia, obesity, inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, bacterial urinary tract infections, furunculosis, skin abscesses, pulmonary tuberculosis, bronchitis, cough with difficult sputum expectoration, intestinal parasitic infestations.

Use of Bauhinia purpurea in Mixtures and Complexes: chronic heart failure, ischemic heart disease, atherosclerosis, chronic obstructive pulmonary disease, bronchial asthma, chronic gastritis, peptic ulcer disease of the stomach and duodenum, chronic colitis, intestinal dysbiosis, chronic pyelonephritis, urolithiasis, benign prostatic hyperplasia, iron deficiency anemia, general exhaustion of the body.

Pharmacological Properties of Bauhinia purpurea: antioxidant, hepatoprotective, hypoglycemic, hypolipidemic, anti-inflammatory, analgesic, antibacterial, antifungal, antitubercular, expectorant, immunomodulatory, wound-healing, anthelmintic, cardioprotective, diuretic, antiproliferative, antitumor, antispasmodic, adaptogenic.

Dosage of Pharmaceutical Forms — Bauhinia purpurea

Powder — Bauhinia purpurea

Indications (Powder): chronic inflammatory liver diseases, non-alcoholic fatty liver disease, liver cirrhosis, type 2 diabetes mellitus, hyperglycemia, hyperlipidemia, obesity, inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, bacterial urinary tract infections, furunculosis, skin abscesses, pulmonary tuberculosis, bronchitis, cough with difficult sputum expectoration, intestinal parasitic infestations.

Standard Dosage (Powder): 2–3 grams of powder twice a day, taken with warm water, 30 minutes before meals.

Enhanced Dosage (Powder): 4 grams of powder twice a day during exacerbation of chronic inflammatory liver diseases, severe hyperglycemia, hyperlipidemia, and acute bacterial urinary tract infections.

Maximum Dosage (Powder): 5 grams of powder twice a day for severe forms of chronic inflammatory liver diseases and type 2 diabetes mellitus with decompensation, for a course not exceeding 14 days.

Preventive Dosage (Powder): 1–1.5 grams of powder once a day for the prevention of non-alcoholic fatty liver disease, hyperlipidemia, in patients with excess body weight and a hereditary predisposition to type 2 diabetes mellitus, in courses of 30 days with a 60-day break.

Pediatric Dosage (Powder): for children over 12 years old weighing from 40 kg — 0.5–1 gram of powder 1–2 times a day; for children under 12 years old and weighing less than 40 kg, safety data are not scientifically registered.

Contraindications (Powder): individual intolerance, acute gastritis, peptic ulcer disease in the acute stage; data on contraindications during pregnancy, lactation, and in children under 12 years old are not scientifically registered.

Side Effects (Powder): with overdose, nausea, diarrhea, headache are possible.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 25%; for body weight over 90 kg, increase by 15%.

Preparation method (Powder): Ingredients for 100 g of product: dry bark or leaves of Bauhinia purpurea — 100 g. Wash the raw material thoroughly, dry at a temperature not exceeding 50 °C in a shaded, well-ventilated area, grind in a mill to a fine powder state (particle size no more than 0.2 mm), sieve through a sieve. Store in an airtight container.

Storage Conditions and Shelf Life (Powder): store in a dry place, protected from light, at a temperature from +5 °C to +25 °C, in airtight packaging, shield from electromagnetic radiation. Shelf life — 24 months; after opening, use within 60 days.

Dry Extract — Bauhinia purpurea

Indications (Dry Extract): chronic inflammatory liver diseases, non-alcoholic fatty liver disease, liver cirrhosis, type 2 diabetes mellitus, hyperglycemia, hyperlipidemia, obesity, inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, bacterial urinary tract infections, furunculosis, skin abscesses, pulmonary tuberculosis, bronchitis, cough with difficult sputum expectoration, intestinal parasitic infestations.

Standard Dosage (Dry Extract): 250–500 mg of extract twice a day, 30 minutes before meals.

Enhanced Dosage (Dry Extract): 750 mg twice a day for severe hyperglycemia, hyperlipidemia, acute urinary tract infections, and active inflammatory process in the liver.

Maximum Dosage (Dry Extract): 1 g twice a day for severe chronic liver diseases and type 2 diabetes mellitus with complications, for a course not exceeding 10 days.

Preventive Dosage (Dry Extract): 250 mg once a day in courses of 30 days for the prevention of hyperlipidemia, fatty liver disease, in patients with metabolic syndrome.

Pediatric Dosage (Dry Extract): for children over 12 years old weighing from 40 kg — 125–250 mg 1–2 times a day; for children under 12 years old, safety data are not scientifically registered.

Contraindications (Dry Extract): individual intolerance, acute gastritis, peptic ulcer disease in the acute stage; data on contraindications during pregnancy, lactation, and in children under 12 years old are not scientifically registered.

Side Effects (Dry Extract): with overdose, nausea, vomiting, diarrhea, dizziness are possible.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 20%; for body weight over 90 kg, increase by 15%.

Preparation method (Dry Extract): Ingredients for 100 g of finished product: dry bark or leaves of Bauhinia purpurea — 500 g, 70% ethanol — 3 l (for extraction only). Grind the raw material to a fraction of 3–5 mm, pour over with ethanol, infuse for 72 hours at a temperature of +25 °C, stirring periodically. Filter, evaporate in a water bath at a temperature not exceeding 50 °C until the solvent odor is completely removed. Residual ethanol content in the finished product should not exceed 500 ppm. Dry to a powdery state in a vacuum drying oven.

Storage Conditions and Shelf Life (Dry Extract): store in a dry place, protected from light, at a temperature of +5 °C...+25 °C, in an airtight container, shield from electromagnetic radiation. Shelf life — 24 months; after opening, use within 30 days.

Tincture — Bauhinia purpurea

Indications (Tincture): chronic inflammatory liver diseases, non-alcoholic fatty liver disease, liver cirrhosis, type 2 diabetes mellitus, hyperglycemia, hyperlipidemia, obesity, inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, bacterial urinary tract infections, furunculosis, skin abscesses, pulmonary tuberculosis, bronchitis, cough with difficult sputum expectoration, intestinal parasitic infestations.

Standard Dosage (Tincture): 5 ml of tincture (1:5, 40% ethanol) twice a day, diluted in 50 ml of warm water, 30 minutes before meals.

Enhanced Dosage (Tincture): 7.5 ml twice a day for severe hyperglycemia, hyperlipidemia, acute urinary tract infections, inflammatory liver processes.

Maximum Dosage (Tincture): 10 ml twice a day for severe chronic inflammatory liver diseases and type 2 diabetes mellitus with complications, course not exceeding 14 days.

Preventive Dosage (Tincture): 2.5–3 ml once a day in courses of 20 days, 3 times a year, for the prevention of hyperlipidemia and fatty liver disease in patients with metabolic syndrome.

Pediatric Dosage (Tincture): for children over 14 years old — 1–2 ml of tincture 1–2 times a day; for children under 14 years old, use is not recommended.

Contraindications (Tincture): individual intolerance, chronic alcoholism, acute and chronic stomach diseases in the acute stage, alcoholic liver cirrhosis, pregnancy, lactation, children under 14 years old.

Side Effects (Tincture): with overdose — nausea, dizziness, vomiting, tachycardia.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 25%; for body weight over 90 kg, increase by 10%.

Preparation method (Tincture): Ingredients for 100 g of finished product: dry bark or leaves of Bauhinia purpurea — 20 g, 40% ethanol — 100 ml (for extraction only). Grind the raw material to a fraction of 3–5 mm, pour over with ethanol, infuse for 14 days in a dark place at +20...+25 °C, shaking daily. Strain, filter. To reduce alcohol content if necessary — evaporate part of the solution in a water bath at a temperature not exceeding 50 °C to the desired concentration; residual ethanol content — within the norm for internal use (not exceeding 0.5% for diluted forms).

Storage Conditions and Shelf Life (Tincture): store in an airtight dark glass container at a temperature of +5...+20 °C, in a place protected from light, shield from electromagnetic radiation. Shelf life — 3 years; after opening, use within 60 days.

Oil Infusion — Bauhinia purpurea

Indications (Oil Infusion): inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, furunculosis, skin abscesses, skin tuberculosis, chronic bronchitis with persistent cough, bacterial skin infections, slow-healing wounds, burns, parasitic skin diseases.

Standard Dosage (Oil Infusion): apply a thin layer to the affected skin area 2–3 times a day.

Enhanced Dosage (Oil Infusion): apply 3–4 times a day for pronounced inflammatory and purulent-necrotic skin lesions, arthritis with active pain syndrome.

Maximum Dosage (Oil Infusion): 5–6 applications per day for severe inflammatory skin and joint diseases, course not exceeding 14 days.

Preventive Dosage (Oil Infusion): 1–2 applications per day on joints in patients with chronic osteoarthritis during the off-season, during remission, in courses of 10 days every 2 months.

Pediatric Dosage (Oil Infusion): for children over 6 years old — 1–2 applications per day; for children under 6 years old, safety data are not scientifically registered.

Contraindications (Oil Infusion): individual intolerance to components, deep infected wounds with abundant purulent discharge without systemic therapy; data on contraindications during pregnancy and lactation are not scientifically registered.

Side Effects (Oil Infusion): with overdose — local skin irritation, hyperemia, itching.

Adjustment for Patient Body Weight: dose adjustment is not required.

Preparation method (Oil Infusion): Ingredients for 100 g of finished product: dry flowers or leaves of Bauhinia purpurea — 20 g, edible coconut oil — 100 ml. Grind the raw material to a fraction of 3–5 mm, pour over with oil in a glass container, keep in a water bath at a temperature of 40–45 °C for 6 hours, stirring periodically. Strain through cheesecloth, store in an airtight container.

Storage Conditions and Shelf Life (Oil Infusion): store in a dark glass container in a cool place at +5...+15 °C, protected from light, shield from electromagnetic radiation. Shelf life — 12 months; after opening, use within 30 days.

Cream — Bauhinia purpurea

Indications (Cream): chronic inflammatory skin diseases, atopic dermatitis, eczema, psoriasis, bacterial skin infections, slow-healing wounds, first- and second-degree burns, furunculosis, skin abscesses, skin tuberculosis, post-traumatic scars, osteoarthritis with periarticular inflammation, rheumatoid arthritis with joint capsule involvement.

Standard Dosage (Cream): apply a thin layer to the affected skin area twice a day.

Enhanced Dosage (Cream): apply three times a day for pronounced inflammatory and purulent skin lesions, as well as active pain syndrome in the joint area.

Maximum Dosage (Cream): 4 applications per day on limited skin areas for severe dermatological inflammatory diseases, course not exceeding 21 days.

Preventive Dosage (Cream): 1 application per day in courses of 7 days each month to prevent exacerbation of chronic skin diseases and joint inflammation during the off-season.

Pediatric Dosage (Cream): for children over 6 years old — 1–2 applications per day on limited skin areas; for children under 6 years old, safety data are not scientifically registered.

Contraindications (Cream): individual intolerance to components, open extensive bleeding wounds; data on contraindications during pregnancy and lactation are not scientifically registered.

Side Effects (Cream): with overdose — skin irritation, hyperemia, peeling, itching.

Adjustment for Patient Body Weight: dose adjustment is not required.

Preparation method (Cream): Ingredients for 100 g of finished product: oil infusion from Bauhinia purpurea flowers — 25 g, coconut oil — 25 g, shea butter — 20 g, beeswax — 10 g, distilled water — 20 g. Melt shea butter, coconut oil, and beeswax in a water bath at 40–45 °C, add the oil infusion, slowly introduce distilled water with constant stirring until an emulsion forms. Pour into a sterile jar.

Storage Conditions and Shelf Life (Cream): store in a cool place at +5...+15 °C, protected from light, in an airtight container. Shelf life — 6 months; after opening, use within 30 days.

Cosmetic Lotion — Bauhinia purpurea

Indications (Lotion): chronic inflammatory skin diseases, acne, post-acne, skin hyperpigmentation, couperose, bacterial skin infections, seborrheic dermatitis, skin itching, photoaging, dry skin, decreased skin elasticity.

Standard Dosage (Lotion): apply with a cotton pad to cleansed skin of the face and body twice a day.

Enhanced Dosage (Lotion): 3 applications per day for active inflammatory and bacterial skin processes, pronounced pigmentation.

Maximum Dosage (Lotion): 4 applications per day on limited skin areas for severe dermatological conditions, course not exceeding 14 days.

Preventive Dosage (Lotion): 1 application per day in courses of 10 days each month to prevent acne exacerbation and hyperpigmentation.

Pediatric Dosage (Lotion): for children over 12 years old — 1–2 applications per day on limited skin areas; for children under 12 years old, safety data are not scientifically registered.

Contraindications (Lotion): individual intolerance to components; data on contraindications during pregnancy and lactation are not scientifically registered.

Side Effects (Lotion): with overdose — skin dryness, irritation, peeling.

Adjustment for Patient Body Weight: dose adjustment is not required.

Preparation method (Lotion): Ingredients for 100 g of finished product: dry extract of Bauhinia purpurea — 2 g, rose hydrolate — 50 g, distilled water — 45 g, vegetable glycerin — 3 g. Mix hydrolate and water, introduce the extract and glycerin, mix thoroughly until homogeneous, filter through a sterile filter. Pour into sterile bottles with a dispenser.

Storage Conditions and Shelf Life (Lotion): store in a dark, cool place at +5...+15 °C, in an airtight container. Shelf life — 3 months; after opening, use within 20 days.

Pack-Pouch (Powder or Mask) — Bauhinia purpurea

Indications (Pack-Pouch): acne, post-acne, skin hyperpigmentation, seborrheic dermatitis, couperose, inflammatory skin diseases, photoaging, wrinkles, decreased skin elasticity, enlarged pores, oily seborrhea.

Standard Dosage (Pack-Pouch): apply the prepared paste (diluted with water or hydrolate to a sour cream consistency) to cleansed skin of the face and neck once a day for 15–20 minutes, then rinse with warm water.

Enhanced Dosage (Pack-Pouch): twice a day for pronounced hyperpigmentation, active inflammatory eruptions.

Maximum Dosage (Pack-Pouch): 2–3 times a day on limited skin areas for severe dermatological manifestations, course not exceeding 10 consecutive days.

Preventive Dosage (Pack-Pouch): once a week in courses of 3 months to maintain skin cleanliness and elasticity, prevent acne and pigmentation.

Pediatric Dosage (Pack-Pouch): for children over 12 years old — 1 application per week; for children under 12 years old, safety data are not scientifically registered.

Contraindications (Pack-Pouch): individual intolerance, acute purulent skin lesions with copious discharge; data on contraindications during pregnancy and lactation are not scientifically registered.

Side Effects (Pack-Pouch): with overdose — skin dryness, peeling, local irritation.

Adjustment for Patient Body Weight: dose adjustment is not required.

Preparation method (Pack-Pouch): Ingredients for 100 g of finished product: powder from dry leaves of Bauhinia purpurea — 50 g, oat flake powder — 30 g, white cosmetic clay — 20 g. Mix ingredients until homogeneous, package in airtight pouches. For application, dilute 1 tablespoon of the mixture in 30 ml of warm water or hydrolate, mix until a homogeneous paste forms.

Storage Conditions and Shelf Life (Pack-Pouch): store in a dry place at a temperature of +5...+25 °C, in an airtight container. Shelf life — 12 months; the diluted product should be used immediately.

Emulsion — Bauhinia purpurea

Indications (Emulsion): dry skin, decreased skin elasticity, photoaging, hyperpigmentation, atopic dermatitis in remission, seborrheic dermatitis, acne, inflammatory skin diseases, mild first-degree burns, skin cracks.

Standard Dosage (Emulsion): apply a thin layer to the skin twice a day.

Enhanced Dosage (Emulsion): three times a day for pronounced skin dryness and inflammation, hyperpigmentation.

Maximum Dosage (Emulsion): four times a day on limited skin areas for pronounced inflammatory or pigmentary changes, course not exceeding 14 days.

Preventive Dosage (Emulsion): 1 application per day in courses of 14 days every 2 months to prevent skin dryness and photoaging.

Pediatric Dosage (Emulsion): for children over 6 years old — 1–2 applications per day; for children under 6 years old, safety data are not scientifically registered.

Contraindications (Emulsion): individual intolerance to components; data on contraindications during pregnancy and lactation are not scientifically registered.

Side Effects (Emulsion): with overdose — mild burning, skin hyperemia, peeling.

Adjustment for Patient Body Weight: dose adjustment is not required.

Preparation method (Emulsion): Ingredients for 100 g of finished product: oil infusion of Bauhinia purpurea — 20 g, coconut oil — 20 g, emulsifier (beeswax) — 10 g, distilled water — 50 g. Heat the oil phase (oil infusion, coconut oil, wax) to 45 °C, heat the aqueous phase (distilled water) to the same temperature. Combine, stir until a homogeneous emulsion forms, cool and package in sterile containers.

Storage Conditions and Shelf Life (Emulsion): store in a refrigerator at +5...+10 °C, in light-protected containers. Shelf life — 3 months; after opening, use within 20 days.

Liniment — Bauhinia purpurea

Indications (Liniment): inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, myalgia, neuralgia, chronic inflammatory skin diseases, furunculosis, skin abscesses, trophic ulcers, slow-healing wounds, first- and second-degree burns.

Standard Dosage (Liniment): apply a thin layer to the affected skin area or joint area twice a day, rubbing in lightly.

Enhanced Dosage (Liniment): three times a day for pronounced inflammatory and pain syndromes in joints and muscles, active skin inflammations.

Maximum Dosage (Liniment): 4 applications per day on limited skin and joint areas, course not exceeding 14 days.

Preventive Dosage (Liniment): 1 application per day in courses of 7–10 days every 2 months to prevent exacerbations of osteoarthritis and rheumatoid arthritis during the off-season.

Pediatric Dosage (Liniment): for children over 12 years old — 1–2 applications per day; for children under 12 years old, safety data are not scientifically registered.

Contraindications (Liniment): individual intolerance to components, extensive open wounds, purulent processes without systemic treatment; data on contraindications during pregnancy and lactation are not scientifically registered.

Side Effects (Liniment): with overdose — skin irritation, hyperemia, burning.

Adjustment for Patient Body Weight: dose adjustment is not required.

Preparation method (Liniment): Ingredients for 100 g of finished product: oil infusion of Bauhinia purpurea — 40 g, coconut oil — 30 g, beeswax — 10 g, vegetable glycerin — 20 g. Heat the oil phase to 40–45 °C, add glycerin, mix thoroughly until a viscous semi-liquid consistency is obtained. Cool, package in an airtight container.

Storage Conditions and Shelf Life (Liniment): store in a dark glass container at +5...+15 °C, in a place protected from light. Shelf life — 12 months; after opening, use within 30 days.

Foam — Bauhinia purpurea

Indications (Foam): acne, seborrheic dermatitis, bacterial skin infections, skin itching, photoaging, hyperpigmentation, inflammatory skin diseases, dry skin, decreased skin elasticity, chronic inflammatory diseases of the external genital mucosa (for external use).

Standard Dosage (Foam): apply to damp skin, lather, leave for 1–2 minutes, then rinse with warm water, twice a day.

Enhanced Dosage (Foam): three times a day for active inflammatory eruptions, seborrhea, pronounced hyperpigmentation.

Maximum Dosage (Foam): four times a day on limited skin areas for severe dermatological manifestations, course not exceeding 7 days.

Preventive Dosage (Foam): once a day in courses of 14 days every 2 months to maintain skin cleanliness and prevent inflammation.

Pediatric Dosage (Foam): for children over 6 years old — 1–2 uses per day; for children under 6 years old, safety data are not scientifically registered.

Contraindications (Foam): individual intolerance to components; data on contraindications during pregnancy and lactation are not scientifically registered.

Side Effects (Foam): with overdose — skin dryness, peeling, irritation.

Adjustment for Patient Body Weight: dose adjustment is not required.

Preparation method (Foam): Ingredients for 100 g of finished product: lavender hydrolate — 40 g, distilled water — 40 g, soft plant-based cleansing base (without SLS) — 15 g, dry extract of Bauhinia purpurea — 5 g. Mix hydrolate and water, add the cleansing base, then introduce the extract, mix carefully until homogeneous. Pour into a bottle with a foam dispenser.

Storage Conditions and Shelf Life (Foam): store at +5...+15 °C, in a dark container. Shelf life — 3 months; after opening, use within 20 days.

Plaster — Bauhinia purpurea

Indications (Plaster): osteoarthritis, rheumatoid arthritis, myalgia, neuralgia, localized inflammatory joint diseases, chronic inflammatory skin diseases, furunculosis, skin abscesses, post-traumatic soft tissue contusions, edema.

Standard Dosage (Plaster): apply the plaster to cleansed and dry skin over the affected area for 8–12 hours, change once a day.

Enhanced Dosage (Plaster): change the plaster every 8 hours for pronounced pain syndrome and inflammation.

Maximum Dosage (Plaster): 3 plaster changes per day on limited skin areas, course not exceeding 10 days.

Preventive Dosage (Plaster): application once every 2 days in courses of 7 days every 2 months in patients with chronic osteoarthritis or rheumatoid arthritis in remission.

Pediatric Dosage (Plaster): for children over 12 years old — use once a day; for children under 12 years old, safety data are not scientifically registered.

Contraindications (Plaster): individual intolerance to components, skin damage at the application site, purulent inflammatory skin processes without systemic therapy; data on contraindications during pregnancy and lactation are not scientifically registered.

Side Effects (Plaster): with overdose — skin irritation, hyperemia, itching.

Adjustment for Patient Body Weight: dose adjustment is not required.

Preparation method (Plaster): Ingredients for 100 g of active layer: oil infusion of Bauhinia purpurea — 30 g, beeswax — 20 g, pine resin — 10 g, cocoa butter — 10 g, cotton fabric — 30 g. Melt the oil infusion, wax, resin, and cocoa butter in a water bath at 45 °C, mix, apply evenly to the fabric, cool. Cut into plates and package in an airtight container.

Storage Conditions and Shelf Life (Plaster): store in a dry, cool place at +5...+15 °C, in airtight packaging. Shelf life — 12 months; after opening, use within 7 days.

Granules — Bauhinia purpurea

Indications (Granules): chronic inflammatory liver diseases, non-alcoholic fatty liver disease, liver cirrhosis, type 2 diabetes mellitus, hyperglycemia, hyperlipidemia, obesity, inflammatory joint diseases, osteoarthritis, rheumatoid arthritis, bacterial urinary tract infections, furunculosis, pulmonary tuberculosis, bronchitis, intestinal parasitic infestations.

Standard Dosage (Granules): 2–4 g of granules twice a day, taken with warm water, 30 minutes before meals.

Enhanced Dosage (Granules): 5 g twice a day for pronounced hyperglycemia, hyperlipidemia, exacerbation of inflammatory liver diseases.

Maximum Dosage (Granules): 6 g twice a day for severe forms of chronic liver diseases and type 2 diabetes mellitus, course not exceeding 14 days.

Preventive Dosage (Granules): 1–2 g once a day for the prevention of hyperlipidemia and fatty liver disease, in courses of 30 days with a 60-day break.

Pediatric Dosage (Granules): for children over 12 years old — 0.5–1 g 1–2 times a day; for children under 12 years old, safety data are not scientifically registered.

Contraindications (Granules): individual intolerance, acute gastritis, peptic ulcer disease in the acute stage; data on contraindications during pregnancy, lactation, and in children under 12 years old are not scientifically registered.

Side Effects (Granules): with overdose — nausea, diarrhea, headache.

Adjustment for Patient Body Weight: for body weight less than 60 kg, reduce the dose by 25%; for body weight over 90 kg, increase by 15%.

Preparation method (Granules): Ingredients for 100 g of finished product: dry extract of Bauhinia purpurea — 50 g, maltodextrin powder — 30 g, natural honey — 20 g. Mix the extract and maltodextrin thoroughly, add honey, mix until evenly moistened, pass through a granulator, dry at a temperature of 40 °C, package in an airtight container.

Storage Conditions and Shelf Life (Granules): store in a dry place, protected from light, at +5...+25 °C, in airtight packaging. Shelf life — 12 months; after opening, use within 30 days.

Toxicity and Biosafety of Bauhinia purpurea

Studies on rats and mice have established that upon oral administration of a hydroalcoholic extract of the bark of Bauhinia purpurea (or its parts), the lethal dose (LD₅₀) exceeds 2 g/kg of body weight in acute toxicity, and subchronic use also revealed no toxic effect sciencedirect.com+9pmc.ncbi.nlm.nih.gov+9stuartxchange.org+9.

Furthermore, when using an ethanolic root extract, the intraperitoneal LD₅₀ also exceeded 4 g/kg of body weight ijpcbs.com. The study confirms a favorable safety profile for oral use at doses well below these thresholds.

Pharmacodynamics — Bauhinia purpurea

The pharmacodynamic activity of Bauhinia purpurea is due to a complex of biologically active compounds, including flavonoids, biflavonoids, phytosterols, phenolic acids, triterpenoids, and tannins. These substances implement a wide range of physiological effects, interacting with various body systems at systemic and local levels.

Extracts of the plant demonstrate pronounced anti-inflammatory action by suppressing the synthesis of inflammatory mediators and reducing the activity of enzymes involved in inflammatory cascades. The analgesic effect is associated with peripheral reduction of pain receptor sensitivity and partial modulation of nociceptive transmission in the central nervous system.

Antioxidant properties are manifested in the ability of flavonoids and phenolic compounds to neutralize free radicals, increase the activity of endogenous antioxidant defense enzymes, and prevent oxidative damage to cell membranes. This effect provides cytoprotection in liver, kidney, skin, and mucous membrane tissues.

Cardioprotective and metabolic action is implemented through the regulation of lipid and carbohydrate metabolism, influence on enzymatic systems involved in cholesterol synthesis and utilization, as well as mechanisms of glycemia regulation. These effects are systemic in nature and include an indirect influence on the endocrine system.

The plant's immunomodulatory potential is associated with an effect on phagocyte activity, cytokine production, and inhibition of pathogenic microorganism growth. Antimicrobial activity covers a wide spectrum of Gram-positive and Gram-negative bacteria, as well as some types of fungi.

Local application of extracts and oil forms promotes wound healing, stimulates fibroblast proliferation, enhances collagen synthesis, and reduces tissue swelling and hyperemia. There is evidence of cytostatic activity against some cell lines, attributed to the action of polyphenols and triterpenes.

Thus, Bauhinia purpurea possesses a complex pharmacodynamic profile, including anti-inflammatory, analgesic, antioxidant, cytoprotective, metabolic, cardioprotective, immunomodulatory, and antimicrobial action, implemented through interaction with enzyme systems, inflammatory mediators, receptor structures, and cell membranes under systemic and local exposure.

References:
https://pmc.ncbi.nlm.nih.gov/a...
https://scirp.org/journal/pape... 
https://www.sciencedirect.com/science/article/abs/pii/S0944711324009036

Pharmacokinetics — Bauhinia purpurea

Pharmacokinetic data on Bauhinia purpurea are limited, but based on the characteristics of known groups of its active substances, general patterns can be described.

Upon oral intake of powder or dry extract, polyphenolic and flavonoid compounds are partially hydrolyzed in the intestine, undergo metabolism by microflora to form aglycones, which are absorbed in the small intestine. Water-soluble fractions quickly enter the bloodstream, lipophilic components undergo lymphatic transport and accumulate in tissues with high lipid content — liver, skin, adipose tissue.

Upon transdermal application (cream, emulsion, liniment), active substances penetrate the stratum corneum, reaching the dermal layer and local vascular networks. This provides local action with minimal systemic load.

Distribution among tissues depends on the lipophilicity of the molecules: flavonoids and triterpenoids tend to bind to cell membranes and plasma proteins, phenolic acids are distributed more evenly.

Metabolism occurs in the liver through oxidation, methylation, glucuronidation, and sulfation. Conjugates are excreted with bile into the intestine or with urine through the kidneys. A small amount of volatile components and metabolites may be excreted through the lungs and skin.

With topical and transdermal administration, metabolism and excretion depend on the degree of absorption; most of the components remain in the skin and are gradually broken down by local enzymes.

Thus, the pharmacokinetics of Bauhinia purpurea is characterized by intestinal absorption of hydrolyzed forms, tissue distribution in the liver, skin, and adipose tissue, hepatic metabolism with conjugation and excretion primarily by the kidneys and bile, as well as limited systemic absorption with external use.

References:
https://pmc.ncbi.nlm.nih.gov/a...
https://japsonline.com/abstrac...
https://scirp.org/journal/pape...

Mechanisms of Action — Bauhinia purpurea

The pharmacological activity of Bauhinia purpurea is due to a complex of biologically active compounds — flavonoids, biflavonoids, triterpenes, phytosterols, phenolic acids, and tannins. These substances act on key targets in the body, exerting both systemic and local influence.

Plant extracts demonstrate analgesic and anti-inflammatory action by inhibiting the activity of COX and LOX enzymes, leading to reduced synthesis of prostaglandins and leukotrienes. This modulates the activity of macrophages and neutrophils, reducing the severity of inflammatory processes.

The antioxidant effect is provided by the ability of phenolic compounds to neutralize reactive oxygen species, enhance the activity of superoxide dismutase, catalase, and glutathione peroxidase. This reduces the level of oxidative stress, protects cell membrane lipids from peroxidation, and stabilizes the structure of proteins and DNA.

Hepatoprotective and cytoprotective action is associated with the regulation of lipid peroxidation, modulation of NF-κB and MAPK signaling pathways, and increased resistance of cell membranes to toxic effects.

Antimicrobial activity is due to disruption of bacterial membrane integrity and inhibition of enzymes necessary for pathogen replication. A potentiating effect on antibiotics has been noted due to increased permeability of bacterial cells and blocking of pumps responsible for drug efflux.

Metabolic and cardioprotective action is implemented through activation of PPAR-γ and AMPK, which promotes normalization of lipid and carbohydrate metabolism, improves endothelial function, and maintains cellular energy balance.

A stimulating effect on fibroblast proliferation and collagen synthesis has also been identified, accelerating tissue regeneration and healing processes.

References:
https://pmc.ncbi.nlm.nih.gov/a...
https://pmc.ncbi.nlm.nih.gov/a...
https://www.sciencedirect.com/science/article/abs/pii/S0944711324009036

Synergy — Bauhinia purpurea

Research shows that Bauhinia purpurea can exhibit pharmacological synergy with a number of natural and synthetic compounds.

When combining a methanolic plant extract with β-lactam antibiotics, aminoglycosides, and lincosamides, a reduction in the minimum inhibitory concentration against resistant strains of Staphylococcus aureus is observed. The mechanism of this effect is associated with disruption of bacterial membrane integrity and inhibition of efflux pumps, which increases the intracellular concentration of antibacterial agents.

Flavonoid components of the plant, including ausdoglyin and β-sitosterol, when used in combination with phytomaterials containing metabolically active substances (e.g., Camellia sinensis or Curcuma longa), demonstrate additive and potentiating effects in activating PPAR-γ and AMPK, enhancing the regulation of lipid and carbohydrate metabolism.

In combination with antioxidant sources such as Emblica officinalis and Vitis vinifera, extracts of Bauhinia purpurea enhance free radical neutralization and stimulate the expression of antioxidant defense enzymes, increasing tissue resistance to oxidative stress.

Synergy with plants containing tannins and triterpenes, e.g., Terminalia chebula, in stimulating wound healing — through joint activation of fibroblasts and increased collagen synthesis — has also been noted in experiments.

References:
https://www.frontiersin.org/jo...
https://www.scirp.org/journal/...
https://www.researchgate.net/p...

Geography of Use and Folk Medicine — Bauhinia purpurea

Bauhinia purpurea has a wide range of ethnobotanical applications in South and Southeast Asia, as well as in a number of regions of Africa and Oceania. In the traditional medicine of India (Ayurvedic school), it is known as a plant used in the form of decoctions, infusions, and powders for internal and external use. In rural communities of Sri Lanka and Nepal, bark and leaves are used to prepare aqueous extracts, flowers are used in cooking and as a component of tonic infusions. In Thai folk medicine and the "cherven" system (a local ethnomedical practice of the northern provinces), leaves and flowers are part of multicomponent mixtures used in the form of warm wraps and compresses.

In Laos and Cambodia, the plant is found in traditional phytobaths and ritual fumigations, where dry parts of the plant are burned in combination with aromatic resins. Among the peoples of Myanmar, bark and leaves are included in the formulations of means used in ritual cleansing of dwellings and the body. In Malay ethnoculture, flowers are sometimes used in decorations and ritual drinks associated with harvest celebrations.

Historical mentions of the use of Bauhinia purpurea are found in Indian and Chinese herbals of the 17th–18th centuries, where it is described as an ornamental and medicinal plant. In the folklore of some Indian communities, the bauhinia is considered a "plant of power," symbolizing resilience and renewal, and is often planted near temples. In some regions of Southeast Asia, plant branches were used in weather and fertility prediction rituals.

In non-medical aspects, the plant was used as an element of festive garlands, decorative branches in religious ceremonies, and in aromatic compositions for fumigating rooms.