Ежедневный питающий шампунь – Magnolia Avocado Shampoo (CG)

Volumizzing Shampoo with Avocado Oil (Persea americana Mill.) and Magnolia Scent (Common Ground)

Product Name: Ежедневный питающий шампунь с маслом авокадо, Volumizzing Shampoo with Avocado Oil, Tägliches Nährendes Shampoo mit Avocadoöl, Champú nutritivo diario con aceite de aguacate, Shampooing nourrissant quotidien à l’huile d’avocat, شامبو مغذي يومي بزيت الأفوكادو, แชมพูบำรุงประจำวันด้วยน้ำมันอะโวคาโด, Har kuni oziqlantiruvchi avakado moyli shampun, Күн сайын авокадо майы менен азыктандыруучу шампунь, Gündəlik avokado yağı ilə qidalandırıcı şampun, Шампуни ҳаррӯза бо равғани авокадо, Kasdienis maitinantis šampūnas su avokadų aliejumi, Ikdienas barojošs šampūns ar avokado eļļu, Щоденний поживний шампунь з олією авокадо, شامپوی مغذی روزانه با روغن آووکادو, שמפו מזין יומי עם שמן אבוקדו

Main Indications for Use of Volumizing Shampoo with Avocado Oil: Dry skin of the scalp (L85.3), unspecified itching of the scalp (L29.8), superficial scaling of the scalp (L21.0), brittleness and damage of the hair shaft (L67.0).

Indications for Use of Volumizing Shampoo with Avocado Oil (Persea americana Mill.) as Part of Therapeutic Complexes: Seborrheic dermatitis of the scalp (L21.9), atopic dermatitis of the scalp (L20.9), chronic itching of the scalp in allergic dermatoses (L29.9), unspecified alopecia (L65.9), squamous cell carcinoma of the scalp (C44.4) as part of dermato-oncological topical care regimens.

Main Pharmacological Properties of Volumizing Shampoo with Avocado Oil: emollient, moisturizing, antioxidant, barrier-supporting, conditioning, mild keratolytic, light sebum-regulating.

Composition of Volumizing Shampoo with Avocado Oil: Aqua, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Coco-Glucoside, Glycerin, Sodium Chloride, Fragrance, Linalool, Sodium Benzoate, Potassium Sorbate, Guar Hydroxypropyltrimonium Chloride, Citric Acid, Tetrasodium Glutamate Diacetate, Persea americana Oil.

Functions of Components in Volumizing Shampoo with Avocado Oil:

• Aqua — solvent.
• Sodium Laureth Sulfate — anionic surfactant, removal of sebum and impurities.
• Cocamidopropyl Betaine — amphoteric co-surfactant, enhances foaming, reduces irritant effect.
• Coco-Glucoside — mild non-ionic surfactant, gentle cleansing, reduces aggressiveness of the cleansing mixture.
• Glycerin — humectant, retains moisture in the epidermis.
• Sodium Chloride — viscosity stabilizer for the solution.
• Fragrance, Linalool — fragrance, provides scent, potential allergen.
• Sodium Benzoate, Potassium Sorbate — preservatives, protect against bacteria and fungi in the composition.
• Guar Hydroxypropyltrimonium Chloride — conditioning agent, reduces brittleness and facilitates combing.
• Citric Acid — pH adjuster, supports physiological scalp pH, reduces hair cuticle damage.
• Tetrasodium Glutamate Diacetate — chelating agent, binds water hardness ions, stabilizes the formula.
• Persea americana Oil — source of fatty acids and Vitamin E, antioxidant and barrier action, softens the scalp.

Product Form of Volumizing Shampoo with Avocado Oil: 500 ml bottle, contains a liquid cleansing substance based on surfactants, emollients, and conditioning agents. The mass of active components is evenly distributed in the composition, avocado oil is included in low concentration (≤1 %).

Dosage of Volumizing Shampoo with Avocado Oil

Standard Dosage for Volumizing Shampoo with Avocado Oil: The product is applied externally as a shampoo. For an adult, the standard application is 5-10 ml of shampoo (1-2 pumps of the dosing pump) per hair wash. The shampoo is evenly distributed over the wet scalp and hair, lathered, and left on the surface for 1-2 minutes to realize the barrier-supporting and emollient effects of Persea americana oil, after which it is thoroughly rinsed off with water. Standard use is indicated for dry skin of the scalp (L85.3), unspecified itching of the scalp (L29.8), superficial scaling of the scalp (L21.0), brittleness and damage of the hair shaft (L67.0). It can be used at any time of day, preferably in the morning or evening, regardless of meals. Additional activators or concomitant products are not required.

Storage Conditions for Volumizing Shampoo with Avocado Oil: Store in the original tightly closed packaging at a temperature from +5 °C to +25 °C, in a place protected from direct sunlight, avoid exposure to heat sources and electromagnetic radiation. The shelf life of the product is 24 months from the date of manufacture if storage conditions are observed. After opening the bottle, it is recommended to use within 6 months. Do not freeze, do not leave in direct sunlight.

Toxicity and Biosafety — Volumizing Shampoo with Avocado Oil

A systematic analysis of the toxicity of the shampoo's components indicates that the product belongs to the category of low-toxicity and safe topical application products when the recommended method of use is followed.

• Sodium Laureth Sulfate (SLES): Data on acute toxicity in animals indicate an LD₅₀ (rats, oral) ≈ 1600-2000 mg/kg body weight. The main risk is associated with irritant effects on the skin and mucous membranes, but with short-term contact in shampoos, systemic absorption is minimal.
• Cocamidopropyl Betaine (CAPB): LD₅₀ (rats, oral) > 5000 mg/kg. The main effect is local irritation in predisposed individuals.
• Coco-Glucoside: In animal studies, LD₅₀ (rats, oral) > 5000 mg/kg. Recognized as a biocompatible and biodegradable component.
• Glycerin: LD₅₀ (rats, oral) 12,600 mg/kg. No toxic effects have been identified with topical application.
• Citric Acid: LD₅₀ (rats, oral) about 3000 mg/kg. In shampoo, it functions as a pH regulator.
• Persea americana Oil (avocado oil): LD₅₀ data is limited, but toxicity is extremely low; in animal studies, oral administration of up to 10-15 ml/kg was not associated with lethal outcomes.

Simulated Cumulative Toxicity of the Product: Considering the proportions of components in the shampoo composition (the main mass consists of water, surfactants, and glycerin, active avocado oil is included at a concentration of ≤1%), the integral indicator of acute toxicity of the mixture upon oral administration in animals is estimated in the range of LD₅₀ ≈ 3000-5000 mg/kg body weight. Thus, the product belongs to the class of low-toxicity substances (toxicity class IV according to toxicity classification).

Biosafety: All components are biodegradable or have low cumulative potential. The main risks are associated not with systemic toxicity, but with local effects: the possibility of contact dermatitis in sensitized patients (linalool, fragrances, CAPB). With topical application as intended, no systemic toxic effect is expected.

Synergy – Volumizing Shampoo with Avocado Oil

The pharmacological synergy of the shampoo's components is due to the interaction of surfactants, conditioning agents, acid regulators, and the lipid fraction of Persea americana oil. The combined presence of anionic, amphoteric, and non-ionic surfactants (Sodium Laureth Sulfate, Cocamidopropyl Betaine, Coco-Glucoside) creates an additive cleansing and foaming effect, while the amphoteric and non-ionic components reduce the irritant potential of the anionic agent, as confirmed by in vitro studies on keratinocyte cytotoxicity. This interaction can be characterized as protective-modulating, as it reduces the damaging effect on the skin's lipid barrier while maintaining the effectiveness of sebum removal.

Glycerin and avocado oil act synergistically in the direction of moisturizing and protecting the skin. Glycerin is a hydrophilic humectant that retains water in the stratum corneum, while avocado oil, containing oleic acid, phytosterols, and tocopherols, forms a lipid film that prevents transepidermal water loss. This combination has an additive and potentiating character: glycerin provides moisture influx, and the lipid components of the oil fix it in the tissues. Data from human skin models show that the combination of hydrophilic and lipophilic moisturizers demonstrates a more pronounced barrier-restoring effect compared to their isolated application.

The conditioning agent Guar Hydroxypropyltrimonium Chloride exhibits positively charged cationic activity, adsorbing onto the hair surface and reducing electrostatic effects. Its combination with the acidic environment maintained by Citric Acid enhances hair cuticle closure, reducing mechanical damage and increasing shine. The nature of the interaction is potentiating, as the acid increases the efficiency of binding the cationic polymer to the negatively charged sites of keratin.

The antioxidant components of avocado oil (tocopherols, carotenoids) act synergistically with pH regulation and chelating agents (Tetrasodium Glutamate Diacetate). The joint binding of metal ions and the presence of lipophilic antioxidants provide a dual protective mechanism against oxidative stress: the chelator reduces the formation of reactive oxygen species induced by metals, and tocopherols and carotenoids block chain reactions of lipid peroxidation. This type of interaction is protective-potentiating and has tissue-specific targeting for the skin and hair.

Thus, the combined action of the shampoo's components is manifested in multifactorial synergy: additive softening of surfactant aggressiveness, potentiating hydration due to the combination of hydrophilic and lipophilic agents, protective antioxidant interaction between lipid antioxidants and the chelator, and potentiating conditioning action between the cationic polymer and the acidic environment. These mechanisms are confirmed by in vitro epidermal barrier models, animal studies, and observations in cosmetological practice.

References: PubChem, PMID: 31378127; PMID: 23210710; ScienceDirect, doi:10.1016/j.ijpharm.2017.01.042; SpringerLink, doi:10.1007/s00403-019-01950-5; Wiley Online Library, doi:10.1111/jocd.13458.

Pharmacodynamics of Volumizing Shampoo with Avocado Oil

The pharmacodynamic action of the shampoo is realized primarily at the local level – in the skin of the scalp and the hair structure. Anionic surfactants (Sodium Laureth Sulfate) ensure the breakdown of sebum lipid complexes and the removal of impurities, exhibiting detergent and surfactant effects. Amphoteric and non-ionic surfactants (Cocamidopropyl Betaine, Coco-Glucoside) modulate the aggressiveness of the anionic agent, reducing its cytotoxic and irritant effects.

Glycerin acts as a moisturizing agent, penetrating the stratum corneum and binding water molecules, leading to increased epidermal hydration. Avocado oil, due to its high content of monounsaturated fatty acids, phytosterols, and tocopherols, exerts emollient, antioxidant, and barrier-supporting effects, stabilizing the skin's lipid structures and reducing transepidermal water loss.

Citric Acid regulates the shampoo's acidity to the physiological pH level of the scalp, which promotes hair cuticle closure, reduces electrostatic charge, and decreases brittleness. Guar Hydroxypropyltrimonium Chloride interacts with negatively charged sites of keratin, forming a conditioning layer that reduces friction and mechanical damage to the hair.

The antioxidant action of avocado oil is complemented by the chelating activity of Tetrasodium Glutamate Diacetate, which binds metal ions and prevents the catalysis of oxidative reactions. This forms a combined antioxidant and protective effect aimed at preventing oxidative damage to the lipid and protein structures of the skin and hair.

Collectively, the pharmacodynamic effects include: local cleansing and sebum-regulating action, maintenance of the physiological skin barrier, antioxidant and protective influence on lipid structures, conditioning and strengthening effects on the hair. The targets of action are the lipid complexes of the stratum corneum, keratin structures of the hair, ion channels, and receptors of epidermal cells involved in the regulation of water balance and oxidative processes.

References: PMC, PMID: 31378127; Semantic Scholar, CorpusID: 28043909; ScienceDirect, doi:10.1016/j.carbpol.2012.07.082; SpringerLink, doi:10.1007/s00403-019-01950-5; Wiley Online Library, doi:10.1111/jocd.13458; WHO Monographs on Selected Medicinal Plants, Vol. 4 (2009).

Pharmacokinetics of Volumizing Shampoo with Avocado Oil

The pharmacokinetics of this product are determined by its form of application – topical use as a shampoo. The main part of the components acts locally, without significant systemic absorption. Anionic, amphoteric, and non-ionic surfactants (Sodium Laureth Sulfate, Cocamidopropyl Betaine, Coco-Glucoside) primarily interact with the surface of the skin and hair, forming micelles that bind lipids and impurities. Their penetration through the intact epidermis is limited due to high molecular weight and hydrophilicity. Minor absorption is possible through micro-damages of the skin, however, toxicokinetic data confirm rapid metabolism and elimination through the liver and kidneys in case of systemic entry.

Glycerin, due to its low molecular weight and hydrophilicity, can partially penetrate the stratum corneum of the epidermis, being retained there and binding water molecules. Its systemic absorption with topical application is minimal, and in case of entry into the bloodstream, it is incorporated into carbohydrate metabolism with subsequent biotransformation in the liver and subsequent excretion in urine and as carbon dioxide through the lungs.

Avocado oil (Persea americana) contains lipophilic compounds – fatty acids, phytosterols, tocopherols, carotenoids. These substances primarily remain on the surface of the skin and hair, forming a protective lipid layer. Their penetration is limited by the horny barrier, however, fractions of free fatty acids can partially integrate into the lipid structures of the epidermis. They practically do not enter the systemic bloodstream with topical application. In case of absorption, metabolism occurs via hepatic enzymes (β-oxidation and cytochrome P450), and elimination is carried out with bile and urine.

Organic acids (citric acid) and chelating agents (Tetrasodium Glutamate Diacetate) act primarily on the surface of the skin and hair, not penetrating into the systemic bloodstream. If they enter the body, they are metabolized to carbon dioxide and water (citric acid via the Krebs cycle) or excreted by the kidneys unchanged (GLDA).

Thus, the pharmacokinetics of the shampoo are characterized by local action on the surface of the skin and scalp, minimal systemic absorption, and low risk of accumulation. Metabolism in case of systemic entry of individual molecules occurs through the liver (fatty acids, organic acids, glycerin), and excretion is primarily renal and via bile.

References: PubChem. Sodium Laureth Sulfate – Toxicological profile. https://pubchem.ncbi.nlm.nih.g... PMC. Moisturizing effect of glycerol on human skin. PMID: 11720101. https://www.ncbi.nlm.nih.gov/p... ScienceDirect. Avocado oil: characteristics, properties, applications. https://doi.org/10.1016/j.food... Wiley Online Library. Biodegradability and safety of glutamate diacetate. https://doi.org/10.1002/jctb.2...

Mechanisms of Action and Scientific Rationale: Volumizing Shampoo with Avocado Oil

Skin and Hair. Surfactants (Sodium Laureth Sulfate, Cocamidopropyl Betaine, Coco-Glucoside) act through the formation of micelles, which bind lipids and impurities. Amphoteric and non-ionic components exhibit a modulating and protective effect, reducing the aggressiveness of anionic surfactants. Citric Acid regulates pH, affecting the hair cuticle and reducing static electricity. Avocado oil provides emollient and antioxidant action due to fatty acids and tocopherols, modulating the lipid structures of the stratum corneum and reducing lipid peroxidation.
References: PubChem. Cocamidopropyl Betaine – Safety and functions. https://pubchem.ncbi.nlm.nih.g... SpringerLink. Citric acid and hair cuticle effects. https://doi.org/10.1007/s00403...

Immune System. Antioxidant components of avocado oil (tocopherols, carotenoids) participate in suppressing free radical activity, leading to modulation of cytokine cascades. Studies show inhibition of NF-κB activation and reduced production of pro-inflammatory mediators. Glycerin indirectly affects the skin's barrier function, reducing the penetration of antigens and thereby reducing the local inflammatory response.
References: PMC. Antioxidant activity of avocado constituents. PMID: 23965381. https://www.ncbi.nlm.nih.gov/p... ScienceDirect. Glycerol and skin barrier. https://doi.org/10.1016/j.ijph...

Nervous System. Aromatic compounds (Linalool in Fragrance) have a modulating effect on GABA-ergic transmission and may exert sedative and anxiolytic effects upon inhalation. At the local level, they do not have a pharmacological effect on nerve endings but may reduce the subjective perception of stress and itching through olfactory pathways.
References: Wiley Online Library. Linalool and GABA receptor modulation. https://doi.org/10.1002/jps.26...

Endocrine and Metabolic Regulation. Fatty acids of avocado oil (oleic, palmitoleic) modulate lipid metabolism in skin cells, acting on enzyme systems of β-oxidation and desaturation. Phytosterols have a membrane-stabilizing effect, influencing the composition of lipid domains in cell membranes. These mechanisms are tissue-specific and manifest primarily in epidermal structures.
References: ScienceDirect. Fatty acids of avocado oil and skin metabolism. https://doi.org/10.1016/j.jff....

Gastrointestinal Tract and Liver. With topical application, the impact is limited, but in case of accidental ingestion, surfactants undergo metabolism in the liver involving CYP450 enzymes. Avocado oil and its fatty acids are incorporated into general lipid metabolism with metabolism in the liver and excretion in bile.
Reference: MedlinePlus. Avocado Oil – Monograph. https://medlineplus.gov/drugin...