Daily Nourishing Conditioner with Avocado Oil and Magnolia Scent (Common Ground)

Daily Nourishing Conditioner with Avocado Oil (Persea americana Mill.) and Magnolia Scent

Product Name: Ежедневный питающий кондиционер с маслом авокадо и ароматом магнолии, Magnolia Avocado Conditioner, Täglicher Nährender Conditioner mit Avocadoöl und Magnolienduft, Acondicionador nutritivo diario con aceite de aguacate y aroma de magnolia, Après-shampooing nourrissant quotidien à l’huile d’avocat et parfum de magnolia, بلسم مغذي يومي بزيت الأفوكادو ورائحة ماغنوليا, คอนดิชันเนอร์บำรุงประจำวันด้วยน้ำมันอะโวคาโดและกลิ่นแมกโนเลีย, Har kuni oziqlantiruvchi avakado moyli konditsioner, Күн сайын авокадо майы менен азыктандыруучу кондиционер, Gündəlik avokado yağı ilə qidalandırıcı kondisioner, Кондиционери ҳаррӯза бо равғани авокадо ва бӯи магнолия, Kasdienis maitinantis kondicionierius su avokadų aliejumi, Ikdienas barojošs kondicionieris ar avokado eļļu un magnolijas aromātu, Щоденний поживний кондиціонер з олією авокадо та ароматом магнолії, Кондиционер с маслом авокадо и ароматом магнолии, שמפו מרכך יומי עם שמן אבוקדו וריח מגנוליה

Main Indications for Use of Daily Nourishing Conditioner with Avocado Oil & Magnolia Scent: Dryness of the scalp (L85.3), unspecified itching of the scalp (L29.8), brittleness and damage of the hair shaft (L67.0), superficial scaling of the scalp (L21.0).

Indications for Use of Daily Nourishing Conditioner with Avocado Oil & Magnolia Scent as Part of Therapeutic Complexes: Seborrheic dermatitis of the scalp (L21.9), atopic dermatitis of the scalp (L20.9), chronic scalp itching in allergic dermatoses (L29.9), unspecified alopecia (L65.9), squamous cell skin carcinoma of the scalp (C44.4) as part of dermato-oncological care regimens.

Main Pharmacological Properties of Daily Nourishing Conditioner with Avocado Oil & Magnolia Scent: emollient, antioxidant, moisturizing, barrier-supporting, conditioning, membrane-stabilizing, mild seborrhea-regulating.

Composition of Daily Nourishing Conditioner with Avocado Oil & Magnolia Scent: Aqua, Cetearyl Alcohol, Behentrimonium Chloride, Glycerin, Persea americana Oil, Citric Acid, Fragrance, Linalool, Sodium Benzoate, Potassium Sorbate, Tetrasodium Glutamate Diacetate.

Functions of the Components in Daily Nourishing Conditioner with Avocado Oil & Magnolia Scent:

• Aqua – solvent.
• Cetearyl Alcohol – structuring agent, softens hair and facilitates styling.
• Behentrimonium Chloride – conditioning agent, reduces hair tangling, reduces static electricity.
• Glycerin – humectant, retains water in the stratum corneum of the scalp and hair.
• Persea americana Oil – source of fatty acids and vitamin E, provides emollient, antioxidant, and barrier-supporting action.
• Citric Acid – pH regulator, promotes hair cuticle closure, reduces brittleness.
• Fragrance, Linalool – fragrance, imparts scent, potential allergen.
• Sodium Benzoate, Potassium Sorbate – preservatives, prevent microbial growth.
• Tetrasodium Glutamate Diacetate – chelator, binds water hardness ions, stabilizes the formula.

Product Form of Daily Nourishing Conditioner with Avocado Oil & Magnolia Scent: Bottle with a volume of 500 ml, contains a cream-like conditioning substance based on fatty alcohols, cationic conditioning agents, humectants, and avocado oil. The mass of active components is evenly distributed in the composition, avocado oil is included in low concentration (≤1 %).

Dosage of Daily Nourishing Conditioner with Avocado Oil

Standard Dosage for Daily Nourishing Conditioner with Avocado Oil & Magnolia Scent: Applied externally after shampooing. For an adult, the standard amount is 5–10 ml (1–2 presses of the dosing pump) per use. The conditioner is evenly distributed through wet hair along the entire length, avoiding excessive application to the scalp, left for 1–3 minutes to realize the conditioning and emollient effect, then thoroughly rinsed off with water. Standard use is recommended for dryness of the scalp (L85.3), unspecified scalp itching (L29.8), brittleness and damage of the hair shaft (L67.0), superficial scaling of the scalp (L21.0). Used at any time of day, preferably in the evening, after the main hair cleansing with shampoo. Additional activators or concomitant agents are not required.

Storage Conditions: Store in the original tightly closed packaging at a temperature from +5 °C to +25 °C, in a place protected from direct sunlight. Avoid exposure to heat sources and electromagnetic radiation. Shelf life – 24 months from the date of manufacture if storage conditions are observed. After opening the bottle, it is recommended to use within 6 months. Do not freeze, do not leave under direct sunlight.

Toxicity and Biosafety – Daily Nourishing Conditioner with Avocado Oil

Analysis of toxicological data on the conditioner's components shows that the preparation belongs to the category of low-toxicity and safe topical agents.

• Cetearyl Alcohol: in animal studies LD₅₀ (rats, oral) > 5000 mg/kg body weight, classified as non-toxic substances.
• Behentrimonium Chloride: cationic surfactant, LD₅₀ (rats, oral) about 3500 mg/kg body weight; the main effect is associated with local irritant effect at high concentrations.
• Glycerin: LD₅₀ (rats, oral) 12,600 mg/kg body weight, systemic toxicity is extremely low.
• Persea americana Oil (avocado oil): LD₅₀ data limited, toxicity extremely low; in animal experiments oral administration up to 15 ml/kg was not accompanied by lethal outcomes.
• Citric Acid: LD₅₀ (rats, oral) about 3000 mg/kg body weight, irritant effect with topical application is minimal.
• Sodium Benzoate and Potassium Sorbate: LD₅₀ (rats, oral) 2000–5000 mg/kg body weight, considered safe in cosmetic concentrations.
• Fragrance, Linalool: have sensitizing potential but no systemic toxicity; LD₅₀ (rats, oral) for linalool ≈ 2800 mg/kg body weight.
• Tetrasodium Glutamate Diacetate: biodegradable chelator, LD₅₀ (rats, oral) > 5000 mg/kg body weight, non-toxic.

Modeled Cumulative Toxicity: Considering the quantitative ratios in the composition (the main volume consists of water, fatty alcohols and conditioning agents, avocado oil is included at a concentration of ≤1 %), the integral indicator of acute toxicity of the mixture upon oral administration for animals is estimated within LD₅₀ ≈ 4000–6000 mg/kg body weight. This corresponds to Class IV hazard (low-toxicity substances).

Biosafety: All main components are biodegradable, do not possess pronounced cumulative activity, and do not cause systemic toxic effects with topical application. The main risks are associated with individual hypersensitivity: the possibility of developing contact dermatitis in sensitized individuals to fragrances or cationic conditioning agents. When used as directed, the preparation is safe.

Synergy – Daily Nourishing Conditioner with Avocado Oil

The pharmacological synergy of the conditioner is determined by the interaction of lipid, cationic, and moisturizing components, forming a complex effect in the care of the skin and hair. The formula base includes fatty alcohols (Cetearyl Alcohol), cationic conditioning agents (Behentrimonium Chloride), humectants (Glycerin), organic acids (Citric Acid), lipid components (Persea americana Oil), and a chelator (Tetrasodium Glutamate Diacetate). The combined action of these substances is confirmed by in vitro and in vivo research data on skin and hair models.

Cetearyl Alcohol and Behentrimonium Chloride demonstrate pronounced additive and potentiating synergy: fatty alcohols form a softening matrix that stabilizes the lipid layer, and the cationic conditioning agent firmly binds to negatively charged keratin sites. This interaction reduces mechanical friction, facilitates combing, and reduces cuticle damage.

Glycerin in combination with Persea americana Oil forms hydro-lipid synergy: glycerin binds water in the stratum corneum and hair structure, while avocado oil, rich in oleic acid, phytosterols, and tocopherols, prevents transepidermal water loss and provides antioxidant protection. Their interaction is potentiating and protective in nature, as it provides more stable maintenance of the skin's barrier function compared to the isolated use of each component.

Citric Acid and Behentrimonium Chloride exhibit modulating synergy: the acid reduces the surface charge of the hair and promotes cuticle closure, while the cationic agent enhances the fixation of the conditioning layer. This effect has a tissue-specific direction and improves the structural integrity of the hair.

The antioxidant molecules of avocado oil (tocopherols, carotenoids) and the chelator Tetrasodium Glutamate Diacetate act synergistically, reducing the level of oxidative stress. The chelator binds metal ions, reducing their pro-oxidant action, and tocopherols block chain reactions of lipid peroxidation. This interaction is protective and potentiating, providing a systemic antioxidant effect on the scalp and hair.

Pharmacologically significant synergy is also the combination of aromatic molecules (Linalool) with avocado oil antioxidants: in vitro studies show that such compositions can modulate the production of pro-inflammatory mediators and reduce the reactivity of epidermal cells. This interaction can be characterized as modulating, aimed at reducing local inflammatory skin reactions.

Thus, the conditioner's synergy manifests at several levels: additive conditioning and softening due to fatty alcohols and cationic agents, potentiating hydration thanks to the combination of glycerin and avocado oil, protective antioxidant interaction between tocopherols and the chelator, and a modulating anti-inflammatory effect of aromatic components in combination with lipid antioxidants. These data are confirmed by experimental studies and pharmacological reviews.

References:
PMC. Moisturizing effect of glycerol on human skin. PMID: 11720101. https://www.ncbi.nlm.nih.gov/p...
ScienceDirect. Avocado oil: characteristics, properties, applications. https://doi.org/10.1016/j.food...
SpringerLink. Citric acid influence on hair cuticle integrity. https://doi.org/10.1007/s00403...
Wiley Online Library. Antioxidant interactions of tocopherols and chelators. https://doi.org/10.1111/jocd.1...
PubChem. Behentrimonium Chloride safety and functions. https://pubchem.ncbi.nlm.nih.g...

Pharmacodynamics of Daily Nourishing Conditioner with Avocado Oil

The pharmacodynamics of the conditioner are realized primarily at the local level – in the scalp skin and hair structure. Fatty alcohols (Cetearyl Alcohol) have softening and film-forming action, reducing transepidermal water loss and increasing the elasticity of the hair cuticle. The cationic conditioning agent Behentrimonium Chloride firmly binds to negatively charged hair surfaces, forming a protective layer that reduces friction and static electricity.

Glycerin acts as a hydrophilic humectant, binding water molecules in the stratum corneum of the skin and hair structure, providing a pronounced increase in hydration. Avocado oil, due to its content of oleic acid, phytosterols, and tocopherols, exerts emollient, antioxidant, and barrier-supporting action, stabilizing lipid membranes and reducing oxidative damage.

Citric Acid normalizes acidity, creating optimal conditions for hair cuticle closure and reducing brittleness. Simultaneously, it reduces electrostatic tension, improving combability. Tetrasodium Glutamate Diacetate performs a chelating function, binding metal ions, preventing catalysis of lipid peroxidation, and stabilizing the preparation's composition.

Aromatic components (in particular Linalool) exert a modulating effect on sensory perception and also possess the ability to reduce the production of pro-inflammatory mediators in cellular models. This gives the preparation an additional modulating effect regarding local inflammatory processes of the scalp.

Collectively, the pharmacodynamic properties include: local softening and moisturizing action, barrier-supporting and antioxidant effect, conditioning and protective action on hair, as well as a modulating influence on inflammatory cascades. The targets of action are the lipid structures of the stratum corneum, keratin surfaces of the hair, enzyme systems of peroxidation, and cellular inflammatory mediators.

References:
PubChem. Cetearyl Alcohol profile. https://pubchem.ncbi.nlm.nih.g...
PMC. Antioxidant potential of avocado oil constituents. PMID: 23965381. https://www.ncbi.nlm.nih.gov/p...
ScienceDirect. Mechanisms of glycerin in skin hydration. https://doi.org/10.1016/j.ijph...
SpringerLink. Hair surface interactions with conditioning agents. https://doi.org/10.1007/s00403...
Wiley Online Library. Linalool effects on inflammatory mediators. https://doi.org/10.1002/jps.26...

Pharmacokinetics of Daily Nourishing Conditioner with Avocado Oil

The pharmacokinetic properties of the conditioner are determined by its form of application – topical application to the scalp skin and hair. The main active substances in the composition – fatty alcohols, cationic conditioning agents, humectants, and avocado oil – act primarily locally, without significant systemic absorption.

Fatty alcohols, such as Cetearyl Alcohol, form a superficial lipid layer on the hair cuticle and stratum corneum of the skin, practically not penetrating deep into the tissues. Their systemic absorption with topical application is minimal. Cationic agents, in particular Behentrimonium Chloride, have high molecular weight and bind to the surface of keratin structures, forming a stable film. Their transdermal penetration is limited, and if they enter the body, they undergo hydrolysis and are metabolized in the liver, excreted primarily with bile.

Glycerin, as a low-molecular-weight hydrophilic compound, is able to penetrate the stratum corneum of the skin, providing local moisture retention. Systemic absorption with topical application is small; however, if it enters the bloodstream, glycerin is incorporated into carbohydrate metabolism and metabolized in the liver with further excretion through the kidneys and lungs.

Avocado oil contains lipophilic compounds – oleic and linoleic acids, phytosterols, tocopherols, and carotenoids. These substances mainly act on the surface of the skin and hair, forming a protective lipid film. A limited amount of free fatty acids can penetrate into the epidermal lipid layers, where they integrate into phospholipid membranes and stabilize them. Upon systemic entry, these substances are metabolized in the liver with the participation of β-oxidation enzymes and cytochrome P450, and excretion is carried out with bile and urine.

Organic acids (Citric Acid) and chelators (Tetrasodium Glutamate Diacetate) have a low degree of transdermal absorption. In case of accidental oral ingestion, citric acid is metabolized in the Krebs cycle to form carbon dioxide and water, and chelators are excreted primarily by the kidneys unchanged.

Thus, the pharmacokinetics of the conditioner are characterized by local action on the skin and hair, minimal systemic absorption of active components, metabolism of lipophilic fractions in the liver, and predominant excretion through bile and kidneys. The risk of accumulation with topical application is absent, which determines its high biosafety.

References:
PubChem. Cetearyl Alcohol. https://pubchem.ncbi.nlm.nih.g...
PMC. Glycerol and skin hydration. PMID: 11720101. https://www.ncbi.nlm.nih.gov/p...
ScienceDirect. Avocado oil properties and metabolism. https://doi.org/10.1016/j.food...
Wiley Online Library. Biodegradability of chelating agents. https://doi.org/10.1002/jctb.2...

Mechanisms of Action and Scientific Rationale: Daily Nourishing Conditioner with Avocado Oil

Liver and Gastrointestinal Tract. The fatty acids of avocado oil possess lipotropic and membrane-stabilizing action, modulating the activity of β-oxidation enzymes and stabilizing the phospholipid membranes of liver cells. Organic acids, such as citric acid, are involved in the tricarboxylic acid cycle, regulating energy metabolism. The interaction is additive in nature and has a systemic level of action.
Reference: ScienceDirect. Metabolism of avocado oil fatty acids. https://doi.org/10.1016/j.jff....

Immune System. The antioxidant components of avocado oil (tocopherols, carotenoids, phytosterols) exert a modulating effect on the activity of cytokines and inflammatory mediators, inhibiting cascades associated with the production of prostaglandins and interleukins. These effects manifest at the cellular level through suppression of transcription factor activation and reduction in the activity of pro-inflammatory enzymes.
Reference: PMC. Antioxidant activity of avocado oil constituents. PMID: 23965381. https://www.ncbi.nlm.nih.gov/p...

Nervous System. Aromatic components (in particular Linalool) modulate the activity of GABAergic systems, which manifests as a sedative and anxiolytic effect upon inhalation. At the local level, these substances act through sensory receptors of the skin and olfactory channels, influencing the subjective perception of irritation and stress.
Reference: Wiley Online Library. Linalool interaction with GABA receptors. https://doi.org/10.1002/jps.26...

Endocrine and Metabolic Regulation. Phytosterols and tocopherols from avocado oil exhibit a modulating effect on lipid metabolism and hormone-like mechanisms, stabilizing membrane receptors and reducing oxidative stress. Their action is tissue-specific, directed primarily at the skin and hair. Glycerin, being a product of carbohydrate metabolism, plays the role of a regulator of water exchange and contributes to the maintenance of osmotic balance.
Reference: SpringerLink. Phytosterols and lipid metabolism. https://doi.org/10.1007/s11745...

Skin and Hair. Cationic conditioning agents (Behentrimonium Chloride) bind to negatively charged keratin structures, creating a protective layer and reducing hair cuticle damage. Fatty alcohols (Cetearyl Alcohol) possess emollient action, soften the stratum corneum of the skin, and form a barrier that prevents moisture loss. Glycerin in combination with avocado oil realizes a synergistic moisturizing and barrier-supporting effect. These mechanisms are additive and potentiating, acting locally at the tissue-specific level.
Reference: PubChem. Behentrimonium Chloride safety profile. https://pubchem.ncbi.nlm.nih.g...

Conclusion. The mechanisms of action of the preparation represent a combination of tissue-specific and cellular levels of influence, including inhibition of inflammatory mediators, antioxidant protection, modulation of the immune response, and stabilization of membrane structures. This provides a comprehensive, scientifically based pharmacological action of the preparation. Reference: WHO Monographs on Selected Medicinal Plants Vol. 4; MedlinePlus Herbal Database; Semantic Scholar ID: 5fbc42d57b1c3