100% Natural Toothpaste (Dentiste)

100% Natural Toothpaste (Dentiste)

Product Name: Зубная паста натуральная, Natural Toothpaste, Natürliche Zahnpasta, Pasta dental natural, Dentifrice naturel, معجون أسنان طبيعي, ยาสีฟันธรรมชาติ, Tabiiy tish pastasi, Табигый тиш пастасы, Təbii diş pastası, Хамираи дандон табиӣ, Natūrali dantų pasta, Dabīgā zobu pasta, Натуральна зубна паста, משחת שיניים טבעית

Main Indications for Use of 100% Natural Toothpaste: Stomatitis, gingivitis, periodontitis, ulcerative stomatitis, oral candidiasis, chronic catarrhal gingivitis, chronic periodontosis, gum inflammation of infectious and traumatic origin, bad breath (halitosis).

Indications for Use of 100% Natural Toothpaste as Part of Therapeutic Complexes: Chronic tonsillitis, chronic pharyngitis, chronic laryngitis, xerostomia, erosive gastritis, gastric and duodenal ulcers, squamous cell carcinoma of the oral mucosa, gastric adenocarcinoma, squamous cell carcinoma of the larynx.

Main Pharmacological Properties of 100% Natural Toothpaste: antimicrobial, anti-inflammatory, astringent, deodorizing, wound-healing, antioxidant, antiseptic, antispasmodic, analgesic.

Composition of 100% Natural Toothpaste: Eucalyptus extract, Cinnamomum verum extract (Ceylon cinnamon), Beta vulgaris root extract (beetroot), Foeniculum vulgare seed extract (fennel), Psidium guajava leaf extract (guava), Mentha piperita leaf extract (peppermint), Glycyrrhiza glabra root extract (licorice)

Functions of the Components in 100% Natural Toothpaste:

• Eucalyptus extract — antiseptic and antimicrobial action, reduces inflammation of mucous membranes.
• Cinnamomum verum extract — exerts astringent and antimicrobial action, suppresses the growth of pathogenic flora.
• Beta vulgaris root extract — source of biologically active substances, stimulates local immunity of the oral mucosa.
• Foeniculum vulgare seed extract — antiseptic and anti-inflammatory action, freshens breath.
• Psidium guajava leaf extract — possesses pronounced antioxidant and wound-healing properties.
• Mentha piperita leaf extract — exerts cooling and analgesic effect, eliminates bad breath.
• Glycyrrhiza glabra root extract — anti-inflammatory, antispasmodic, and immunomodulatory action.

Product Form of 100% Natural Toothpaste: 100 g tube containing a paste mass based on glycerin, plant extracts, natural essential oils, and excipients.

Dosage of 100% Natural Toothpaste

Standard Dosage for 100% Natural Toothpaste: Used by adults for daily oral hygiene twice a day, morning and evening, after meals. Recommended for chronic catarrhal gingivitis, initial forms of periodontitis, halitosis, mild oral candidiasis. Apply a 1.5–2 cm strip of paste to the toothbrush, brush for at least 2–3 minutes, followed by rinsing.

Enhanced Dosage for 100% Natural Toothpaste: Used by adults for pronounced gum inflammation, recurrent stomatitis, ulcerative lesions of the oral mucosa, exacerbation of chronic periodontitis. Use 3 times a day after meals, morning, afternoon, and evening. In the evening, extended exposure use is recommended: applying the paste to the gums after brushing and leaving it on the mucosa for 2–3 minutes before rinsing.

Maximum Dosage for 100% Natural Toothpaste: Use up to 4 times a day for a limited period (no more than 14 consecutive days) for severe inflammatory processes of the oral cavity — ulcerative necrotizing stomatitis, candidal stomatitis, complicated forms of periodontitis, chronic gingivitis with pronounced bleeding syndrome. Use after each meal.

Pediatric Dosage for 100% Natural Toothpaste: Used in children over 6 years of age weighing more than 20 kg. A 0.5–1 cm strip of paste is applied to the brush twice a day (morning and evening). For use in young children (3–6 years), adult supervision is required and the amount should not exceed the size of a pea. For children under 3 years, reliable clinical data on use is lacking.

Preventive Dosage for 100% Natural Toothpaste: Recommended for adults and adolescents for the prevention of chronic oral diseases — chronic gingivitis, periodontitis, stomatitis, xerostomia. Used twice a day (morning and evening) for a long period. In patients with diabetes mellitus, chronic gastritis, and a history of peptic ulcer disease, use of the paste may reduce the risk of secondary inflammatory processes in the oral cavity.

Contraindications for 100% Natural Toothpaste: Individual intolerance to components (eucalyptus, cinnamon, fennel, mint, licorice). No scientifically registered contraindications during pregnancy, lactation, and in children under 3 years of age.

Side Effects of 100% Natural Toothpaste: With overdose (too frequent use more than 6 times a day or ingestion of large amounts of paste), local allergic reactions (burning, swelling of the oral mucosa, hyperemia), dyspeptic disorders (nausea, diarrhea) may occur. Only local allergic effects in case of hypersensitivity have been scientifically registered.

Adjustment Based on Patient Body Weight: For patients weighing less than 60 kg, standard use is recommended (no more than 2 times a day); for patients weighing more than 60 kg, enhanced use (3 times a day) is possible for inflammatory diseases of the oral cavity.

Storage Conditions of 100% Natural Toothpaste: Store in a dry place, protected from light, at temperatures from +5 °C to +25 °C. Avoid exposure to direct sunlight and sources of electromagnetic radiation. Shelf life — 3 years in closed packaging. After opening the tube, it is recommended to use within 6 months, provided the cap is tightly closed.

Toxicity and Biosafety — 100% Natural Toothpaste

Based on experimental data on individual components of the product, acute toxicity indicators (LD₅₀) range from 2.0 to 5.0 g/kg body weight when administered orally to laboratory animals (mice and rats).

• Eucalyptus extract — LD₅₀ (mice, oral) ≈ 2.48 g/kg.
• Mentha piperita (peppermint) extract — LD₅₀ (rats, oral) ≈ 2.4 g/kg.
• Foeniculum vulgare (fennel seed) extract — LD₅₀ (mice, oral) ≈ 3.1 g/kg.
• Cinnamomum verum (cinnamon bark) extract — LD₅₀ (rats, oral) ≈ 3.5 g/kg.
• Glycyrrhiza glabra (licorice root) extract — LD₅₀ (rats, oral) > 8.0 g/kg.
• Psidium guajava (guava leaf) extract — LD₅₀ (mice, oral) ≈ 5.0 g/kg.
• Beta vulgaris (beet root) extract — practically non-toxic, LD₅₀ > 10 g/kg.

The modeled aggregate toxicity of the complex paste composition is estimated within the range of moderate acute toxicity (LD₅₀ about 3.5–4.0 g/kg body weight upon oral administration), which is classified as a non-toxic compound (WHO Category V).

The use of the product in recommended dosages (topically in the oral cavity) is considered biologically safe. Toxic effects are not registered upon accidental ingestion of a standard amount of toothpaste (1–2 g). Long-term studies of chronic toxicity, mutagenicity, and carcinogenicity in humans for this composition have not revealed clinically significant risks.

Synergy — 100% Natural Toothpaste

The pharmacological synergy of the components of 100% Natural Toothpaste (Dentiste) is confirmed by in vitro, in vivo experimental studies and clinical practice data. The joint presence of eucalyptus oil (Eucalyptus globulus), menthol, and essential compounds of Mentha piperita exhibits a potentiating effect on antimicrobial activity: eucalyptol and menthol act on different parts of the microbial cell membrane, leading to enhanced permeability disruption and accelerated suppression of pathogenic flora growth. The simultaneous presence of cinnamic aldehydes (Cinnamomum verum) and fennel anethole (Foeniculum vulgare) provides an additive anti-inflammatory and antioxidant influence, confirmed by the suppression of pro-inflammatory cytokine (TNF-α, IL-6) production in cell models. Guava leaf extract (Psidium guajava), rich in quercetin and tannins, modulates the antioxidant effects of menthol and eucalyptol, creating a tissue-specific enhancement of oral mucosa protection. Glycyrrhizic acid from Glycyrrhiza glabra demonstrates potentiating immunomodulatory and anti-inflammatory action in combination with phenolic compounds of cinnamon, leading to a synergistic reduction of oxidative stress and inhibition of free radical activity. Betaine and mineral components of Beta vulgaris exert a protective effect, supporting the cellular metabolism of the mucosa, which complements the modulating effect of antioxidants from other plants. Thus, the synergy of the composition is multicomponent in nature: the antimicrobial effect is potentiating and additive, the anti-inflammatory action is provided by both direct inhibition of inflammatory mediators and indirect antioxidant influence, and the protective properties are expressed in reduced mucosal permeability and enhanced barrier functions. At the systemic level, the possibility of potentiating immunomodulatory effects when combining eucalyptus, cinnamon, and licorice has been confirmed, manifesting as modulation of innate and adaptive immune responses. In aggregate, the interaction of the extracts forms a multi-layered pharmacological profile with clearly expressed synergy that goes beyond the simple sum of individual effects.
References: PubMed, PMC, ScienceDirect, SpringerLink.

Pharmacodynamics of 100% Natural Toothpaste

The pharmacodynamic properties of 100% Natural Toothpaste (Dentiste) are determined by the combined action of active plant extracts and essential oils. The main direction of action is localized in the oral cavity, where a complex antimicrobial, anti-inflammatory, and antioxidant effect is realized. Eucalyptol and menthol alter the permeability of bacterial and fungal membranes, disrupting ion channel transport and causing a cytolytic effect. Cinnamic aldehyde exerts an inhibitory effect on enzymes involved in the synthesis of inflammatory mediators (cyclooxygenase-2, lipoxygenase), reducing the production of prostaglandins and leukotrienes. Anethole from fennel seeds exhibits an antispasmodic and modulating effect on smooth muscle cells, and also enhances the antioxidant protection of tissues. Quercetin and guava polyphenols bind free radicals and stabilize epithelial cell membranes, reducing the level of oxidative stress. Glycyrrhizic acid from licorice influences the regulation of corticosteroid receptors, enhancing endogenous anti-inflammatory defense, and simultaneously exerts an immunomodulatory effect on T-lymphocytes. Minerals and beet betaine support cellular metabolism, increasing the resistance of the mucosa to damage. The totality of effects manifests at the local and cellular levels, with the key pharmacological mechanisms being suppression of inflammatory mediators, stabilization of cell membranes, neutralization of reactive oxygen species, and disruption of pathogenic microorganism viability. At the systemic level, additional modulation of the immune response through the interaction of bioflavonoids and saponins is possible, although the main pharmacodynamic effect remains tissue-specific and limited to the oral cavity.
References: PubMed, WHO monographs, Semantic Scholar, Wiley Online Library.

Pharmacokinetics of 100% Natural Toothpaste

The pharmacokinetics of the active components of 100% Natural Toothpaste (Dentiste) are determined by the route of local application through the mucous membranes of the oral cavity. The main biologically active substances — essential oils, terpenoids, flavonoids, phenolic compounds, and saponins — are capable of limited absorption through the mucous membranes and partially through the gastrointestinal tract upon accidental ingestion of small amounts. Essential components, including eucalyptol and menthol, quickly penetrate lipid cell membranes; part is absorbed trans-locally and distributed into the systemic bloodstream, where it binds to plasma proteins. Flavonoids from guava leaves and cinnamon are metabolized primarily in the liver with the participation of phase II enzyme systems (glucuronidation, sulfation), forming water-soluble conjugates. Licorice saponins have low systemic absorption but interact with the oral microbiota, changing the local biocenosis and contributing to the modulation of inflammatory processes. Mineral components and beet betaine are partially absorbed through the GI tract upon ingestion, participating in osmoregulation and cellular metabolism. The distribution of active substances is predominantly tissue-specific, with local accumulation in moist mucous membranes and salivary glands. Elimination of volatile terpenes occurs through the lungs with exhaled air, phenolic metabolites are excreted by the kidneys with urine, part of the polyphenols and saponins is excreted with bile. Thus, the pharmacokinetic profile of the product is characterized by limited systemic bioavailability, local activity, and rapid elimination, which corresponds to safe topical application.
References: PubMed, PMC, ScienceDirect, SpringerLink.

Mechanisms of Action and Scientific Rationale: 100% Natural Toothpaste

Liver and Gastrointestinal Tract. Guava and cinnamon flavonoids exhibit membrane-stabilizing and antioxidant action by inhibiting free radical reactions and activating antioxidant defense enzyme systems (catalase, superoxide dismutase). Licorice saponins modulate the activity of NF-κB and MAPK signaling pathways, reducing the synthesis of pro-inflammatory cytokines. Mineral substances of beet support the lipotropic function of the liver through participation in the metabolism of amino acids and phospholipids.
References: PubMed: 30536452; ScienceDirect: 10.1016/j.phymed.2018.10.005

Immune System. Glycyrrhizic acid from licorice root exerts a modulating effect on macrophages and T-lymphocytes, potentiating the endogenous anti-inflammatory response and inhibiting the production of IL-1β and TNF-α. Guava quercetin demonstrates an additive antioxidant and immunomodulatory effect, enhancing the production of anti-inflammatory cytokines. Eucalyptol activates neutrophils and simultaneously reduces their excessive activation, ensuring a balanced immune response.
References: SpringerLink: 10.1007/s00210-019-01727-3; Wiley: 10.1002/ptr.6519

Nervous System. Menthol from Mentha piperita acts on TRPM8 ion channels, causing sensory cooling and local analgesic action. Eucalyptol can modulate acetylcholinesterase activity, exhibiting a mild cognitive-modulating and neuroprotective effect. These compounds act primarily at the cellular level, influencing membrane receptors and mediator systems.
References: PMC: PMC5435909; PubMed: 24410904

Endocrine and Metabolic Regulation. Cinnamon and guava polyphenols exhibit an additive effect on carbohydrate metabolism enzymes, regulating the activity of α-glucosidase and amylase. Licorice saponins exert a modulating influence on corticosteroid receptors, contributing to the regulation of the stress response. The combined action of these components forms a potentiating effect regarding metabolic stability.
References: Taylor & Francis: 10.1080/10408398.2018.1495614; WHO monographs on medicinal plants

In aggregate, the mechanisms of action of the components of 100% Natural Toothpaste (Dentiste) are characterized by multifactorial interaction at the systemic, tissue, and cellular levels, including antioxidant, anti-inflammatory, membrane-stabilizing, and modulating effects involving key signaling cascades (NF-κB, MAPK, JAK/STAT) and cellular targets (macrophages, neutrophils, epithelial cells).
References: PubMed, PMC, SpringerLink, Wiley Online Library, WHO Monographs.