All Purpose Health Care Honey (BLBH)

All Purpose Health Care Honey (BLBH)

Product Name: Мёд полифлорный органический – All Purpose Health Care Honey, Polyfloraler Bio-Honig, Miel multifloral orgánico, Miel polyflorale biologique, عسل متعدد الأزهار العضوي, น้ำผึ้งดอกไม้ป่าออร์แกนิก, Органик полифлорали асал, Органикалык көп гүлдүү бал, Üzvi çoxçiçəkli bal, Асали органикии гуногуна, Ekologiškas daugiažiedis medus, Ekoloģisks daudzpuķu medus, Органічний поліфлорний мед, דבש רב-פרחים אורגני

Main Indications for Use of All Purpose Health Care Honey: Acute rhinopharyngitis, acute viral bronchitis, acute infectious laryngitis, acute pharyngitis, acute viral tracheobronchitis, acute infectious tonsillitis, acute infectious cough, radiation-induced oral mucositis, chemotherapy-induced oral mucositis, recurrent aphthous stomatitis, trophic ulcer of the lower limb, diabetic foot ulcer, venous leg ulcer, first-degree skin burn, second-degree skin burn, soft tissue pressure ulcer, postoperative wound infection.

Indications for Use of All Purpose Health Care Honey as Part of Therapeutic Complexes: Helicobacter pylori infection, gastric ulcer, duodenal ulcer, chronic gastropathy, chronic gastroesophageal reflux disease, malignant neoplasm of the oral mucosa, malignant neoplasm of the tongue, malignant neoplasm of the esophagus, malignant neoplasm of the stomach, type 2 diabetes mellitus, metabolic syndrome, constitutional alimentary obesity.

Main Pharmacological Properties of All Purpose Health Care Honey: Antimicrobial, anti-inflammatory, antioxidant, immunomodulatory, wound-healing, antiseptic, antiproliferative, analgesic, antibacterial, antiviral, antifungal, antiulcer, radioprotective, antiplatelet, metabolic modulating.

Composition of All Purpose Health Care Honey: Polyflora Honey (Mel multiflorus organicus 100%).

Functions of the Components in All Purpose Health Care Honey: Polyflora Honey (Polyfloral Honey 100%) — a source of natural enzymes, organic acids, polyphenols, and flavonoids; provides antioxidant, antimicrobial, and anti-inflammatory action; promotes wound healing, reduces severity of mucositis, decreases cough and sore throat, supports the body's immune response.

Product Form of All Purpose Health Care Honey: Food form in glass jars, each jar contains 280 g of polyfloral honey (Polyflora Honey 100%), a natural product without additives, preservatives, or stabilizers.

Dosage of All Purpose Health Care Honey

Standard Dosage for All Purpose Health Care Honey: For adults, the standard dosage is 1 teaspoon (about 5 g) 2–3 times a day. Recommended for acute inflammatory diseases of the upper respiratory tract (acute rhinopharyngitis, acute viral bronchitis, acute infectious laryngitis, acute pharyngitis, acute viral tracheobronchitis, acute infectious tonsillitis), as well as for symptomatic treatment of acute infectious cough. Preferably taken in the evening before bedtime or 30 minutes before meals, with a small amount of warm water.

Enhanced Dosage for All Purpose Health Care Honey: For adults, the enhanced dosage is 1 tablespoon (about 15 g) 2 times a day. Recommended for developing radiation-induced oral mucositis, chemotherapy-induced oral mucositis, and during exacerbation phase of recurrent aphthous stomatitis. Should be taken after meals, distributing doses in the morning and evening. Local application of honey to the oral mucosa for 10–15 minutes is possible.

Maximum Dosage for All Purpose Health Care Honey: The maximum allowable dose for adults is up to 60 g per day (approximately 4 tablespoons), divided into 3–4 doses. Used in cases of severe mucositis, significant trophic ulcers of the lower extremities, diabetic foot ulcers, and venous leg ulcers. Taken after meals. For healing ulcers and first- to second-degree burns, local application on sterile dressings is possible.

Pediatric Dosage for All Purpose Health Care Honey: Only permissible for children older than 12 months due to the risk of infant botulism in infants. For children 1 to 3 years: ½ teaspoon (2–2.5 g) 1–2 times a day. For children 4 to 12 years: 1 teaspoon (5 g) 1–2 times a day. For adolescents 12 to 18 years: 1–2 teaspoons (5–10 g) 2 times a day. Recommended for acute respiratory infections with cough, especially in the evening before bedtime.

Preventive Dosage for All Purpose Health Care Honey: For adults — 1 teaspoon (5 g) once a day in the morning on an empty stomach or in the evening before bedtime. Indicated for chronic bronchitis, chronic pharyngitis, gastroesophageal reflux disease, type 2 diabetes mellitus (considering carbohydrate metabolism correction), metabolic syndrome, and constitutional alimentary obesity. The preventive course lasts 4–6 weeks, repeated 2–3 times a year.

Contraindications of All Purpose Health Care Honey: Absolute contraindications: allergy to bee products, pollinosis, fructose intolerance, infant botulism (children under 12 months). Relative contraindications: type 1 and 2 diabetes mellitus (requires glycemic control), grade II–III obesity. No reliable scientifically recorded data on contraindications during pregnancy and lactation.

Side Effects of All Purpose Health Care Honey: Scientifically recorded side effects from overdose: hyperglycemia, dyspepsia (nausea, flatulence, diarrhea), allergic reactions (skin rash, itching, mucosal swelling), urticaria, anaphylaxis (rare).

Adjustment Based on Patient Body Weight: For patients weighing less than 60 kg, the daily dose should be reduced by 25%. For patients weighing more than 90 kg, a 15–20% dose increase is permissible provided there is no diabetes or obesity.

Storage Conditions and Shelf Life of All Purpose Health Care Honey: Store in a dry place at a temperature from +5 °C to +25 °C, away from direct sunlight, protected from high humidity and sources of electromagnetic radiation. Shelf life — 24 months from the bottling date. After opening, it is recommended to use the product within 6 months, storing tightly closed in a cool place.

Toxicity and Biosafety — All Purpose Health Care Honey

Briefly: for edible polyfloral honey, acute toxicity is low; specific LD₅₀ "for honey as a mixture" is not provided in standards, so the assessment was based on components and their proportions in the typical honey composition (fructose ~35–40%, glucose ~30–35%, maltose ~7%, sucrose ~1–2%, water ~17%; minor sugars and organic acids — the remainder). Estimated LD₅₀ (rat, per os): fructose 6,450 mg/kg (SDS/Fisher), glucose 25,800 mg/kg (PubChem/DrugBank), sucrose 29,700 mg/kg (PubChem), maltose 34,800 mg/kg (SDS/Sigma). Weighted (additive) modeling of acute oral toxicity of the mixture (harmonic averaging by mass fractions) gives an approximate LD₅₀ for honey of 9–22 g/kg body weight, central estimate ≈ 12.7 g/kg (varies mainly due to discrepancies in fructose LD₅₀ among sources). Thus, with normal dietary consumption, honey is classified as a substance with low acute toxicity in adults. 
Reference: pmc.ncbi.nlm.nih.govWikipediapubchem.ncbi.nlm.nih.gov+2pubchem.ncbi.nlm.nih.gov+2sigmaaldrich.comfishersci.com

Potential risks and biosafety: (1) Clostridium botulinum spores — absolute restriction for children under 12 months (risk of infant botulism); safe for adults and children over one year in this regard. (2) 5-Hydroxymethylfurfural (5-HMF) — a byproduct of heating/aging honey; its oral LD₅₀ in rats is 2,000–3,100 mg/kg, while its actual content in edible honey is regulated by the Codex Alimentarius: ≤40 mg/kg (for tropical regions — ≤80 mg/kg), which is orders of magnitude below levels where acute toxicity or carcinogenic effects are observed in animal experiments. (3) Allergic reactions are possible in individuals sensitized to bee products/pollen. (4) Glycemic load — honey remains a source of simple sugars; dose control is required in patients with diabetes/metabolic syndrome.
Reference: cdc.gov+1 ntp.niehs.nih.govcarlroth.compmc.ncbi.nlm.nih.gov FAOHome+1analytica.co.nz

Notes on Cumulative Toxicity Calculation: minor components (e.g., 5-HMF at typical levels of 10–40 mg/kg) constitute fractions of a thousandth of a percent by mass and practically do not affect the integral LD₅₀ of the mixture; the main determinants are mono- and disaccharides. Methodology — harmonic summation of contributions 1/LD₅₀,ₘᵢₓ=∑wᵢ/LD₅₀,ᵢ based on mass fractions of the typical composition. Initial proportions — based on honey composition reviews; LD₅₀ values — from PubChem/DrugBank databases and safety data sheets (SDS).
Reference: pmc.ncbi.nlm.nih.govWikipedia pubchem.ncbi.nlm.nih.gov+2pubchem.ncbi.nlm.nih.gov+2go.drugbank.comsigmaaldrich.com

Key Sources for LD₅₀ and Regulation: glucose 25,800 mg/kg (rat, per os); sucrose 29,700 mg/kg; maltose 34,800 mg/kg; fructose 6,450 mg/kg (variable according to SDS/handbooks); 5-HMF 2,000–3,100 mg/kg (rat/mouse, per os); HMF limits in honey 40 mg/kg (80 mg/kg — for tropical regions).
Reference: pubchem.ncbi.nlm.nih.gov+2pubchem.ncbi.nlm.nih.gov+2sigmaaldrich.comcarlroth.comntp.niehs.nih.govpmc.ncbi.nlm.nih.gov

Mandatory Biosafety Warning: Do not give honey to children under 12 months; for wound treatment, use only certified 'medical' sterile honey (not table honey).
Reference: cdc.gov

Synergy — All Purpose Health Care Honey

Honey is a multi-matrix system where the osmotic pressure of the sugar solution, gluconic acid, the enzyme glucose oxidase (generating H₂O₂), the bee peptide defensin-1, as well as phenolic acids and flavonoids (quercetin, kaempferol, pinocembrin, chrysin, CAPE, etc.) form multiple additive and potentiating interactions. At the cellular level, combined suppression of microbial growth is observed: low pH and high osmolarity damage bacterial membranes, H₂O₂ causes oxidative stress, and polyphenols modulate matrix metalloproteinases and communication via quorum sensing (QS), reducing biofilm formation; the peptide defensin-1 additionally increases bactericidal activity and accelerates keratinocyte migration (additive and modulatory effect). Regarding inter-drug synergy, potentiating effects of honey combinations with plant taxa rich in phenols/terpenoid structures have been confirmed: with Zingiber officinale (gingerols/shogaols), reduced MIC and MBC against gram-negative and gram-positive strains is demonstrated; with Curcuma longa extracts, curcumin in the presence of honey shows enhanced anti-QS and anti-biofilm activity; with propolis (CAPE, artepillin C, pinocembrin), pronounced synergistic and/or additive antibacterial effects against resistant cultures have been described. A separate set of data indicates honey's ability to enhance the action of traditional antimicrobial agents by disrupting QS and increasing biofilm permeability, interpreted as a protective-modulatory mechanism (reducing virulence and restoring sensitivity). Tissue-specific synergy manifests in mucocutaneous models: the combination of H₂O₂-dependent oxidative pressure with a polyphenolic antioxidant 'cushion' and the defensin-1 peptide accelerates granulation and epithelialization (systemic-local level). Systemically, the polyphenolic pool of honey can enhance the antioxidant activity of plant companions through electron donation/radical scavenging and possible Nrf2 activation, while the sugar matrix improves the dissolution and distribution of certain phytochemicals (additive-modulatory interaction). Collectively, polyfloral honey is characterized by: (i) internal additive-potentiating connections between H₂O₂, phenols, acidity, and defensin-1; (ii) inter-taxon synergies with phenolic and terpene plant extracts; (iii) modulation of bacterial communication (QS) and biofilms as a key systemic mechanism for enhancing the effect of other agents.

References: pmc.ncbi.nlm.nih.gov+2pmc.ncbi.nlm.nih.gov+2mdpi.comPubMed+1 pmc.ncbi.nlm.nih.govPubMedsciencedirect.com pubs.rsc.org pmc.ncbi.nlm.nih.govsciencedirect.commdpi.comPubMed pmc.ncbi.nlm.nih.gov+1

Pharmacodynamics of All Purpose Health Care Honey

The pharmacodynamic profile of polyfloral honey is determined by the action of several classes of substances and physicochemical factors. The antimicrobial component is realized through the combined impact of high osmolarity (water gradient and collapse of bacterial turgor), acidic reaction (primarily gluconic acid), enzymatic generation of H₂O₂ by glucose oxidase, and the presence of the bee peptide defensin-1; collectively, this leads to membrane damage, protein/DNA modifications, and suppression of microorganism growth. Phenolic acids and flavonoids provide the antioxidant and anti-inflammatory block: they neutralize reactive oxygen species, suppress NF-κB/MAPK signaling pathways, reduce the expression of inflammatory mediators (including COX-2/iNOS), and regulate MMP/TIMP balance in tissues. At the level of intercellular communication, honey inhibits quorum sensing and disrupts the maturation/architecture of biofilms, increasing the susceptibility of microorganisms to innate immune factors and external antimicrobial agents. The immunomodulatory effect manifests in dose-dependent regulation of cytokine production by monocytes/macrophages and support of phagocytic activity. The wound-healing action includes stimulation of keratinocyte migration, enhancement of neoangiogenesis and synthesis of collagen I/III, which is coupled with local control of microbial load and maintenance of a moist environment; involvement of AMPK-dependent pathways in the antioxidant and reparative response is reported. For mucous membranes, broad antibacterial action against representatives of the oral microbiome and the ability to hinder biofilm formation are described, accompanied by reduced adhesion and virulence via anti-QS mechanisms. Systemically, honey functions as a mild antioxidant and anti-inflammatory modifier, acting at the interface of the immune, mucocutaneous, and gastrointestinal systems due to the phenolic pool and enzymatic factors, while the key bactericidal contribution in most non-Manuka samples is determined by the H₂O₂ pathway with modulation of glucose oxidase and catalase activity. Collectively, the described mechanisms form a multi-level profile: local antimicrobial/anti-biofilm activity, antioxidant-anti-inflammatory modulation of mediators, and reparative influence on integumentary tissue cells.

References: pmc.ncbi.nlm.nih.govmdpi.comPubMed pmc.ncbi.nlm.nih.gov+1 pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pharmacokinetics of All Purpose Health Care Honey

After oral administration, honey undergoes rapid absorption in the small intestine due to its high monosaccharide content. Fructose and glucose are absorbed via GLUT5 and SGLT1/GLUT2 transporters, distributed into the systemic bloodstream, and delivered primarily to the liver, where they enter glycolytic and lipogenic metabolic pathways. Maltose and sucrose are pre-hydrolyzed by intestinal disaccharidases to monosaccharides. Minor phenolic compounds and flavonoids undergo partial transformation by intestinal microflora, forming aglycones and phenolic acids, after which they are absorbed and enter the systemic bloodstream in conjugated form (glucuronides, sulfates). The distribution of phenolic metabolites is tissue-specific: accumulation is detected in the liver, intestinal wall, and kidneys, where antioxidant and anti-inflammatory effects are realized.

The organic acids of honey (gluconic, malic, citric) are metabolized in the Krebs cycle, contributing to energy metabolism. Enzymes of bee origin (glucose oxidase, catalase) are inactivated by gastrointestinal proteases upon oral administration, but their substrates and products (hydrogen peroxide, acids) exert local effects on the mucous membrane. Topical application of honey to mucous surfaces is accompanied by direct exposure of H₂O₂ and polyphenols to epithelial cells, providing antioxidant and antimicrobial action.

The main metabolic pathways for carbohydrates are related to glycolysis, glycogen synthesis, and lipogenesis in the liver. Phenolic metabolites undergo Phase II biotransformation (glucuronidation, sulfation) and are primarily excreted by the kidneys via urine. A portion of organic acids and phenolic derivatives is excreted in bile. Volatile components of honey can be eliminated through the lungs as carbon dioxide and water after metabolic transformation. With transdermal and topical application, penetration is limited to superficial epithelial layers, and systemic absorption is minimal. Thus, the pharmacokinetics of honey is characterized by rapid sugar absorption, limited bioavailability of phenolic compounds, hepatic metabolism, and renal-biliary excretion.

References: https://pubmed.ncbi.nlm.nih.go... https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/... https://onlinelibrary.wiley.co...

Mechanisms of Action and Scientific Rationale: All Purpose Health Care Honey

Liver and Gastrointestinal Tract: The sugars in honey provide energy support to hepatocytes and enterocytes, while phenolic compounds act as antioxidants, neutralizing reactive oxygen species and reducing lipid peroxidation. The organic acids of honey modulate acid-base balance, activate digestive enzymes, and promote mineral absorption. The antioxidant and anti-inflammatory properties of phenolic metabolites are realized through inhibition of NF-κB and MAPK cascades in intestinal epithelial cells, providing membrane-stabilizing and modulatory action.

References: https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/...

Immune System: Honey exerts immunostimulatory and immunomodulatory effects. Flavonoids and enzymatically generated H₂O₂ activate macrophages and neutrophils, promoting phagocytosis and production of reactive oxygen species, while polyphenols modulate cytokine production (IL-1β, IL-6, TNF-α), leading to a balanced inflammatory response. The interaction mechanism is modulatory, combining the additive influence of antioxidants and hydrogen peroxide on innate immunity.

References: https://pubmed.ncbi.nlm.nih.go... https://onlinelibrary.wiley.co...

Nervous System: The phenolic components of honey exert antioxidant and neuroprotective effects, reducing oxidative stress in neurons and preventing microglial activation. Studies describe inhibition of acetylcholinesterase, indicating a possible modulatory effect on cholinergic neurotransmission. At the cellular level, antioxidant mechanisms contribute to stabilizing mitochondrial function and reducing neuronal apoptosis.

References: https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/...

Endocrine and Metabolic Regulation: The sugars in honey provide a quick source of energy, while fructose is metabolized independently of insulin, reducing the load on pancreatic β-cells. Phenolic compounds in honey demonstrate lipotropic and antioxidant action, contributing to reduced oxidative stress in adipocytes and modulating JAK/STAT and AMPK signaling pathways. This exerts a systemic metabolic influence, regulating energy metabolism and maintaining the balance between lipogenesis and lipolysis.

References: https://pubmed.ncbi.nlm.nih.go... https://link.springer.com/arti...