​Brakshun Stone Oil

Brakshun Stone Oil

Product Name: Каменное масло, Brakshun Stone Oil, Steinöl, Aceite de piedra, Huile minérale, زيت الحجر, น้ำมันหิน

Synonyms: Каменное масло, Бракшун, Белый шилажит, Каменное слёзообразное вещество; Brakshun, Stone oil, White shilajit, Mineral resin; Steinöl, Weißes Mumijo; Aceite mineral, Shilajit blanco; Huile blanche minérale, Résine de roche; شلاجيت أبيض، زيت صخري؛ น้ำมันบรัคชุน, ชีลาจิตขาว

Main Indications for the Use of Brakshun Stone Oil: Gastric ulcer, duodenal ulcer, chronic pyelonephritis, calcium nephrolithiasis, phosphate urolithiasis, renal microlithiasis, chronic cystitis, candidal vaginitis, psoriasis with secondary infection, microbial eczema, trophic ulcers of the lower extremities, seborrheic dermatitis, chronic gastritis, gastroenteritis, vegetative-vascular dystonia, asthenoneurotic syndrome, Alzheimer's disease, chronic ischemic encephalopathy, chronic fatigue syndrome, iron deficiency anemia, metabolic syndrome, type 2 diabetes mellitus.

Use of Brakshun Stone Oil in Mixtures and Complexes: Cytomegalovirus infection, ocular herpes infection, viral pneumonia, chronic urethritis, cryptosporidiosis, candidal urethritis, exacerbation of osteoarthritis, chronic osteomyelitis, purulent-necrotic wounds, Parkinson's disease, hepatocellular carcinoma, benign prostatic hyperplasia, secondary immunodeficiency, chronic hepatitis, steatohepatosis, cholecystitis, cholelithiasis.

Pharmacological Properties of Brakshun Stone Oil: Antioxidant, anti-inflammatory, immunomodulatory, hepatoprotective, neuroprotective, adaptogenic, antimicrobial, antiparasitic, regenerative, gastroprotective, mitochondrial, litholytic, remineralizing, membranoprotective, bacteriostatic, antifungal, trophostimulating, anti-anemic, demineralizing (local).

Dosage of Pharmaceutical Forms — Brakshun Stone Oil

Powder — Brakshun Stone Oil

Indications (Powder): Gastric ulcer, duodenal ulcer, chronic gastritis, chronic pyelonephritis, calcium and phosphate nephrolithiasis, renal microlithiasis, chronic cystitis, candidal vaginitis, seborrheic dermatitis, asthenoneurotic syndrome, vegetative-vascular dystonia, Alzheimer's disease, metabolic syndrome, iron deficiency anemia, type 2 diabetes mellitus.

Standard Dosage (Powder): Dissolve 0.5 to 0.75 grams of powder in 150 milliliters of warm boiled water at a temperature of +36...+38 °C. Leave for 10 minutes until completely dissolved. Take orally through a straw twice a day 30 minutes before meals. Duration of course — 14–30 days.

Enhanced Dosage (Powder): Used for nephrolithiasis with active dissolution of calcium or phosphate concretions up to 7 millimeters, chronic cystitis, psoriasis with secondary infection, chronic osteomyelitis, and chronic fatigue syndrome. Dissolve 0.9 to 1.0 grams of powder in 200 milliliters of water, take twice a day through a straw. Duration of course — 10–21 days.

Maximum Dosage (Powder): Used only under medical supervision for hepatocellular carcinoma, systemic lupus erythematosus, generalized bone demineralization, resistant urolithiasis, and multiple metastatic lesions. Dissolve 1.2–1.3 grams of powder in 250 milliliters of water, take two or three times a day, but no more than 3.9 grams per day. Course — no more than 5 days in a row. Take strictly through a straw.

Preventive Dosage (Powder): Recommended for a tendency to sand formation in the kidneys, chronic cystitis, gastritis, in persons over 45 years of age, and during recovery after COVID-19. Dissolve 0.4–0.5 grams of powder in 120 milliliters of water. Take once a day through a straw. Course — 10–15 days monthly.

Pediatric Dosage (Powder): Used from 10 years of age with a body weight of at least 30 kilograms. Dissolve no more than 0.2 grams of powder in 80 milliliters of warm water. Take once a day through a straw. In case of kidney or liver diseases, use is possible only under medical supervision.

Contraindications (Powder): Contraindicated in hypercalcemia, stage II–III renal failure, calcium stones larger than 7 millimeters in diameter, urinary tract obstruction, and active gastric or intestinal bleeding. Data on contraindications during pregnancy, lactation, and in children under 10 years of age have not been scientifically registered.

Side Effects (Powder): With overdose, metallic taste, bloating, heartburn, spastic pain, nausea, and diarrhea are possible. Effects are completely reversible after discontinuation of the drug. Short-term headache and lethargy are possible.

Adjustment for Patient Body Weight (Powder): For body weight less than 50 kilograms — use 0.3–0.4 grams of powder per 100 milliliters of water. For body weight from 90 kilograms — 0.75–0.9 grams of powder per 200 milliliters of water.

Preparation method (Powder): To prepare the solution, use 0.75 grams of purified Brakshun powder, pour 150 milliliters of warm boiled water at a temperature of +36...+38 °C. Stir for 10–15 minutes until completely dissolved. The prepared solution is consumed immediately after preparation. Do not use metal utensils. Take through a straw to prevent contact with tooth enamel.

Storage Conditions and Shelf Life (Powder): Store the powder in an airtight glass or ceramic container at a temperature of +5 °C to +25 °C, away from sources of light and electromagnetic radiation. Shelf life — up to 2 years. After opening the package, use within 6 months, provided there is no contact with moisture.

Oil Infusion — Brakshun Stone Oil

Indications (Oil Infusion): Trophic ulcers, chronic dermatitis, infected burns, psoriasis with weeping, varicose eczema, seborrheic dermatitis, microbial eczema, chronic osteomyelitis (externally), post-traumatic skin defects.

Standard Dosage (Oil Infusion): Applied to clean skin in a thin layer 2 times a day, morning and evening. For small localized areas, rubbing until absorbed is allowed. Duration of course — 14 days.

Enhanced Dosage (Oil Infusion): In exacerbation of chronic dermatosis, infected wounds, and psoriasis with pronounced weeping, apply up to 3 times a day; application under a gauze bandage for 2–4 hours is allowed. Course — up to 21 days.

Maximum Dosage (Oil Infusion): Continuous application under an occlusive dressing on extensive areas is allowed only under medical supervision. Duration no more than 5 days in a row. Used for trophic ulcers, secondarily infected burns, and varicose eczema with areas of necrosis.

Preventive Dosage (Oil Infusion): Recommended during remission of chronic dermatoses, seasonal exacerbations of seborrheic dermatitis, and dry skin in elderly patients. Apply once a day in the evening to risk zones (shins, elbows, hands). Course — 10–15 days monthly.

Pediatric Dosage (Oil Infusion): Used in children over 7 years of age. Apply once a day on limited areas of skin (no more than 5 cm²). Duration — up to 7 days. Only under medical supervision.

Contraindications (Oil Infusion): Open bleeding wounds, individual hypersensitivity to components, acute purulent processes without drainage. Data on contraindications during pregnancy, lactation, and in children under 7 years of age have not been scientifically registered.

Side Effects (Oil Infusion): With overdose and prolonged use, burning, hyperemia, skin flaking, and a feeling of tightness are possible. When applied under a bandage — skin maceration. All effects are completely reversible.

Adjustment for Patient Body Weight (Oil Infusion): Dose adjustment is not required, as the form is intended for external use. The dosage is adjusted according to the area of application.

Preparation method (Oil Infusion): To prepare 100 grams of product: — Brakshun powder — 3 grams; — cold-pressed sesame oil — 70 grams; — purified beeswax — 20 grams; — tea tree oil — 7 drops. Dissolve the powder in sesame oil at a temperature of +50 °C in a water bath for 30 minutes with stirring. Strain through multi-layer gauze. Add beeswax, bring to complete dissolution. After cooling to +40 °C, add tea tree oil. Mix and package in tubes or jars. Avoid contact with metal objects.

Storage Conditions and Shelf Life (Oil Infusion): Store in a tightly closed glass container at a temperature of +5 °C to +10 °C, in a dark place, protected from light and electromagnetic radiation. Shelf life — up to 3 months. After opening, use within 30 days, avoiding contamination.

Vaginal Suppositories — Brakshun Stone Oil

Indications (Vaginal Suppositories): Candidal vaginitis, bacterial vaginosis, trichuriasis with vaginal invasion, post-antibiotic vaginal dysbiosis, chronic colpitis, mucosal inflammation against the background of chemotherapy, microbial-fungal vaginal infections, viral cervicitis (as part of adjuvant therapy).

Standard Dosage (Vaginal Suppositories): 1 suppository deep intravaginally before bedtime, once a day. Duration of course — 7–10 days. Apply after preliminary hygiene of the external genitalia.

Enhanced Dosage (Vaginal Suppositories): In recurrent candidiasis, mixed infections, and severe dysbiosis — 1 suppository 2 times a day, morning and evening. Duration — up to 14 days; if necessary, the course is repeated after 7 days.

Maximum Dosage (Vaginal Suppositories): In inpatient settings or under strict medical supervision, the use of 1 suppository 3 times a day for no more than 5 days is allowed. Used for resistant microflora, pronounced hyperplasia, and necrotic changes of the mucosa.

Preventive Dosage (Vaginal Suppositories): Prescribed to women with chronic colpitis, frequent recurrences of vaginal candidiasis, in the post-antibiotic period, and during perimenopausal changes. 1 suppository once every 2 days in a course of 7 suppositories. Repeat monthly.

Pediatric Dosage (Vaginal Suppositories): Not used in girls under 14 years of age. In adolescents over 14 years — only by gynecologist's prescription. Use of half a dose (cut suppository) once a day is allowed, course — up to 5 days.

Contraindications (Vaginal Suppositories): Allergy to suppository components, acute bleeding from the genital tract, severe forms of vulvovaginitis with ulcers, oncological diseases of the cervix in the active phase. Data on contraindications during pregnancy and lactation have not been scientifically registered.

Side Effects (Vaginal Suppositories): Burning, increased discharge, mucosal edema in the first 2–3 days with a pronounced reaction of the flora. Herxheimer reaction is possible during lysis of microflora. Side effects are reversible with temporary discontinuation.

Adjustment for Patient Body Weight (Vaginal Suppositories): Not required. The dosage is determined locally, by the area of action. In case of pronounced thinness, it is recommended to insert the suppository in a lying position with maximum deep relaxation.

Preparation method (Vaginal Suppositories): For 100 grams of the drug: — Brakshun powder — 2 grams; — cocoa butter — 90 grams; — aqueous calendula extract — 5 milliliters; — beeswax — 5 grams. Melt the cocoa butter in a water bath to a temperature of +37 °C, add Brakshun powder and aqueous calendula extract, then add wax and mix until a homogeneous mass is obtained. Form into suppository molds of 2 grams volume. Cool at +5 °C. Package the finished suppositories in blisters.

Storage Conditions and Shelf Life (Vaginal Suppositories): Store in the refrigerator at a temperature of +2 °C...+8 °C in a dark place. Avoid exposure to heat and sunlight. Shelf life — up to 2 months. After opening the package, use within 7 days.

Rectal Suppositories — Brakshun Stone Oil

Indications (Rectal Suppositories): Chronic proctitis, hemorrhoids with inflammation, anal fissures, cryptitis, post-radiation proctosigmoiditis, chronic colitis, microbial dysbiosis of the large intestine, parasitic infections of the rectum (giardiasis, trichuriasis), irritable bowel syndrome with a pronounced pain component.

Standard Dosage (Rectal Suppositories): Administer 1 suppository rectally at night after a cleansing enema. Apply in a lying position on the left side. Duration of course — 7–10 days.

Enhanced Dosage (Rectal Suppositories): In acute manifestations of cryptitis, anal fissures, pronounced inflammation, and pain syndrome — 1 suppository 2 times a day: morning and evening. Course — up to 14 days.

Maximum Dosage (Rectal Suppositories): In exacerbation of post-radiation proctitis, uncontrolled hemorrhoidal inflammation, or chronic ulcerative colitis — up to 3 suppositories per day (1 every 8 hours), only under medical supervision. Duration — no more than 5 days.

Preventive Dosage (Rectal Suppositories): Used in patients with recurrent proctitis, a sedentary lifestyle, chronic constipation, and after rectal surgeries. Administer 1 suppository once every 3 days at night. Course — 10 suppositories every 2 months.

Pediatric Dosage (Rectal Suppositories): Use is allowed in children over 10 years of age with a body weight of at least 30 kilograms. Administer half a suppository once a day for 5 days for chronic colitis or parasitosis. Only by doctor's prescription.

Contraindications (Rectal Suppositories): Fresh rectal bleeding, malignant neoplasms of the anorectal area, anal itching of unknown etiology, allergy to components. Data on contraindications during pregnancy, lactation, and in children under 10 years of age have not been scientifically registered.

Side Effects (Rectal Suppositories): Rarely — a burning sensation in the rectum, increased peristalsis, false urges to defecate. With overdose, diarrhea and mucosal irritation are possible. Effects are reversible with temporary discontinuation.

Adjustment for Patient Body Weight (Rectal Suppositories): For body weight less than 50 kilograms — use of 0.5 suppository is allowed. For weight over 90 kilograms — prolongation of the course to 14 days without increasing the dose is possible.

Preparation method (Rectal Suppositories): For 100 grams of the drug: — Brakshun powder — 2.5 grams; — cold-pressed sea buckthorn oil — 85 grams; — beeswax — 12.5 grams. Heat the sea buckthorn oil to +45 °C in a water bath, add Brakshun powder and stir until a suspension is formed. Add beeswax and stir until dissolved. Pour into molds of 2 grams. Cool until solidified at a temperature of +5 °C. Store in individual blisters.

Storage Conditions and Shelf Life (Rectal Suppositories): Store in the refrigerator at a temperature of +2 °C to +8 °C, in a place protected from light, avoiding contact with air. Shelf life — up to 2 months. After opening the blister, use within 5 days.

Nasal Drops — Brakshun Stone Oil

Indications (Nasal Drops): Chronic rhinitis, viral and bacterial rhinopharyngitis, post-viral nasal congestion, hypertrophy of the nasal mucosa, vasomotor rhinitis, allergic rhinitis in remission, sinusitis in the subacute phase, rehabilitation after COVID-19.

Standard Dosage (Nasal Drops): Instill 2 drops in each nostril 2 times a day after rinsing the nose with saline solution. Course — 7–10 days. Use solution at t° +36...+38 °C.

Enhanced Dosage (Nasal Drops): In pronounced mucosal edema, difficulty in nasal breathing, and chronic sinusitis — 3–4 drops 3 times a day. Duration of course — up to 14 days.

Maximum Dosage (Nasal Drops): Allowed in acute inflammation of the nasopharynx with a risk of transition to sinusitis — up to 5 drops 4 times a day, only under ENT supervision. Course — no more than 5 days in a row.

Preventive Dosage (Nasal Drops): Recommended for patients with frequent colds, chronic vasomotor rhinitis, and seasonal allergies (outside exacerbation). 2 drops in each nostril once a day in the evening. Course — 7 days every 2 months.

Pediatric Dosage (Nasal Drops): Used in children from 5 years of age. 1 drop in each nostril once a day. Course — 5 days. Solution at t° +36...+37 °C. Parental supervision during instillation is mandatory.

Contraindications (Nasal Drops): Acute purulent rhinosinusitis, allergy to solution components, history of nosebleeds, perforation of the nasal septum. Data on contraindications during pregnancy and lactation have not been scientifically registered.

Side Effects (Nasal Drops): Burning, temporary increase in edema, sneezing, mucosal irritation. With overdose, short-term loss of smell is possible. All reactions are reversible.

Adjustment for Patient Body Weight (Nasal Drops): Not required. The dosage is determined by age and the condition of the mucosa, not by body weight.

Preparation method (Nasal Drops): To prepare 100 milliliters of solution: — Brakshun powder — 0.5 grams; — purified water — 100 milliliters. Dissolve the powder in water at a temperature of +37 °C with stirring for 15 minutes. Filter the solution through a paper filter or 2 layers of gauze. Transfer to a sterile dropper bottle. The solution should be transparent, without sediment.

Storage Conditions and Shelf Life (Nasal Drops): Store in the refrigerator at a temperature of +2 °C...+8 °C. Avoid exposure to light and heat. Shelf life of a closed bottle — up to 10 days. After opening, use within 3 days.

Ear Drops — Brakshun Stone Oil

Indications (Ear Drops): External otitis, chronic ceruminous otitis, eczema of the external auditory canal, ear mycoses, acute catarrhal external otitis, recurrent itching in the ear canal, inflammation after a healed ear furuncle, supportive therapy for otosclerosis (as part of complex treatment).

Standard Dosage (Ear Drops): Instill 2 drops in the external auditory canal 2 times a day. After instillation, it is recommended to lie on your side for 5 minutes. Course — 5–7 days.

Enhanced Dosage (Ear Drops): In pronounced inflammation, exudative process, or mycosis — 3 drops 3 times a day. Course — up to 10 days, if necessary with subsequent transition to the standard regimen.

Maximum Dosage (Ear Drops): In conditions of short-term therapy in patients with chronic external otitis or pronounced infected eczema, up to 4 drops 4 times a day is allowed. Duration — no more than 4 days.

Preventive Dosage (Ear Drops): Used for a tendency to external otitis, especially in swimmers, patients using hearing aids, and in old age. Instill 2 drops once a day every other day. Course — 6 procedures monthly.

Pediatric Dosage (Ear Drops): Allowed in children over 6 years of age. 1 drop once a day for 3 days. Solution at t° +36...+38 °C. Use only under adult supervision, preferably after a doctor's examination.

Contraindications (Ear Drops): Perforation of the eardrum, presence of purulent discharge, acute purulent otitis media, history of ear surgeries. Data on contraindications during pregnancy and lactation have not been scientifically registered.

Side Effects (Ear Drops): Burning, itching, short-term feeling of ear fullness. When the dosage is exceeded — irritation of the ear canal skin. All effects are reversible upon discontinuation of the drug.

Adjustment for Patient Body Weight (Ear Drops): Not required. The volume of the drug is determined by age and local action.

Preparation method (Ear Drops): For 100 milliliters of the drug: — Brakshun powder — 0.4 grams; — purified water — 80 milliliters; — sesame oil — 20 milliliters. Dissolve Brakshun powder in warm water (+38 °C) until completely transparent. Strain through a filter. Add warm sesame oil and shake to form an emulsion. Transfer to a sterile dropper bottle. Use at t° +36...+38 °C.

Storage Conditions and Shelf Life (Ear Drops): Store in the refrigerator at a temperature of +2 °C to +8 °C, in a place protected from light. Shelf life — up to 7 days after preparation. After opening, use no more than 3 days.

Ointment — Brakshun Stone Oil

Indications (Ointment): Psoriasis, microbial eczema, infected dermatoses, seborrheic dermatitis, varicose eczema, trophic ulcers of the lower extremities, chronic wounds with impaired healing, burns of I–II degree, skin manifestations of diabetes, post-traumatic skin inflammations.

Standard Dosage (Ointment): Apply a thin layer to the affected areas 2 times a day — morning and evening. Rub until partially absorbed. Course — from 7 to 21 days depending on the severity of symptoms.

Enhanced Dosage (Ointment): In exacerbation of trophic ulcers, infected psoriasis, and weeping dermatitis — apply up to 3 times a day; application under a bandage for 2–3 hours is allowed. Course — up to 30 days.

Maximum Dosage (Ointment): Application 4 times a day is allowed for deep inflammation and infected ulcers, but no more than 5 days in a row. Only under medical supervision. The coverage area should not exceed 20% of the body surface.

Preventive Dosage (Ointment): Recommended during remission of chronic dermatoses, seasonal exacerbations, and in patients with diabetic skin dryness. Apply once a day in the evening to risk zones. Course — 10 days monthly.

Pediatric Dosage (Ointment): Used in children over 7 years of age. Apply once a day on limited skin areas. Course — no more than 5 days. Under medical supervision. Do not use under bandages.

Contraindications (Ointment): Individual intolerance to components, open bleeding wounds, allergic dermatitis in the acute stage. Data on contraindications during pregnancy, lactation, and in children under 7 years of age have not been scientifically registered.

Side Effects (Ointment): Burning, redness, dry skin in the first days of use. With overdose or application under a bandage — maceration, increased irritation. All effects are reversible upon discontinuation.

Adjustment for Patient Body Weight (Ointment): Not required. The volume of the product applied is determined by the area of the lesion.

Preparation method (Ointment/Cream): For 100 grams of cream: — Brakshun powder — 2 grams; — aqueous calendula infusion — 10 milliliters; — sesame oil — 20 milliliters; — beeswax — 10 grams; — lanolin — 0.5 grams. Melt the beeswax and sesame oil in a water bath at a temperature of +40 °C. Add Brakshun powder, stir until a suspension is formed. Pour in the calendula infusion, continue stirring. After removing from the bath, add lanolin and bring to homogeneity. Cool and package in glass jars.

Storage Conditions and Shelf Life (Ointment/Cream): Store in an airtight package at a temperature of +5 °C to +10 °C in a place protected from light. Shelf life — up to 3 months. After opening, use within 30 days. Do not freeze.

Cosmetic Serum — Brakshun Stone Oil

Indications (Cosmetic Serum): Atonic skin, age-related changes of the face and neck skin, enlarged pores, pigmentation, post-acne, superficial scars, photoaging, mild skin inflammations, seborrheic and combination skin, prevention of exacerbations in sensitive skin.

Standard Dosage (Cosmetic Serum): Apply 2–3 drops to clean skin of the face and neck once a day, preferably in the evening. Distribute with light movements until completely absorbed. Do not rinse. Course — 21 days.

Enhanced Dosage (Cosmetic Serum): In pronounced pigmentation, enlarged pores, post-acne, and oily seborrhea — apply 2 times a day (morning and evening), 2–3 drops each. Course — up to 30 days.

Maximum Dosage (Cosmetic Serum): In the therapy of pronounced scars, acne marks, and local areas of hyperkeratosis — spot application up to 4 times a day on problem areas is allowed. Duration — no more than 7 days in a row.

Preventive Dosage (Cosmetic Serum): Recommended for patients over 35 years of age, with a tendency to photoaging, dry skin, and stress-induced damage. 2 drops once a day in the evening. Course — 14 days every 2 months.

Pediatric Dosage (Cosmetic Serum): Not recommended for children under 14 years of age. In adolescence (14–18 years) with oily skin and acne — 1–2 drops once a day, pointwise, under the supervision of a cosmetologist.

Contraindications (Cosmetic Serum): Allergy to composition components, active inflammation with weeping, open wounds, acute herpes. Data on contraindications during pregnancy, lactation, and in children under 14 years of age have not been scientifically registered.

Side Effects (Cosmetic Serum): Rarely — burning, flaking, redness. With overdose — a feeling of tightness, dehydration of the epidermis. All effects are reversible after discontinuation of use and restoration of the protective barrier.

Adjustment for Patient Body Weight (Cosmetic Serum): Not required. The volume of application is determined locally by the skin area and does not depend on body weight.

Preparation method (Cosmetic Serum): For 100 milliliters of the drug: — Brakshun powder — 0.3 grams; — lavender hydrolate — 30 milliliters; — freshly squeezed aloe vera juice — 30 milliliters; — purified water — 30 milliliters; — vegetable glycerin — 5 milliliters; — 70% ethyl alcohol (for preservation) — 5 milliliters. Dissolve Brakshun powder in water and hydrolate, add aloe juice and glycerin, mix thoroughly. Add ethyl alcohol. Filter the solution through a sterile filter and pour into bottles with a dispenser. Store in the refrigerator.

Storage Conditions and Shelf Life (Cosmetic Serum): Store in the refrigerator at a temperature of +4 °C...+8 °C, away from light and heat. Shelf life — up to 30 days. After opening, use within 10 days. Shake before use.

Aqueous Solution — Brakshun Stone Oil

Indications (Aqueous Solution): Gastric ulcer, duodenal ulcer, gastritis, chronic cystitis, calcium and phosphate nephrolithiasis, renal microlithiasis, chronic pyelonephritis, candidal vaginitis, immunodeficiency states, post-viral asthenia, iron deficiency anemia, type 2 diabetes mellitus.

Standard Dosage (Aqueous Solution): Dissolve 0.5 to 0.75 grams of powder in 150 milliliters of warm boiled water at a temperature of +36...+38 °C. Leave for 10–15 minutes until completely dissolved. Take orally through a straw twice a day 30 minutes before meals. Course — 14–30 days.

Enhanced Dosage (Aqueous Solution): In nephrolithiasis with active dissolution of stones, microlithiasis, chronic osteomyelitis, peptic ulcer, and post-viral asthenia — 0.9–1.0 grams of powder in 200 milliliters of water, twice a day. Course — 10–21 days.

Maximum Dosage (Aqueous Solution): In hepatocellular carcinoma, generalized bone demineralization, resistant urolithiasis, and systemic lupus erythematosus — 1.2–1.3 grams of powder in 250 milliliters of water, 2–3 times a day. Maximum — 3.9 grams per day. Course — no more than 5 days in a row under medical supervision.

Preventive Dosage (Aqueous Solution): In a tendency to sand formation in the kidneys, chronic infections of the genitourinary system, ulcer history, and in persons over 45 years of age. Dissolve 0.4–0.5 grams in 120 milliliters of water. Take once a day through a straw. Course — 10–15 days monthly.

Pediatric Dosage (Aqueous Solution): Used in children from 10 years of age with a body weight of at least 30 kilograms. Dissolve up to 0.2 grams in 80 milliliters of water. Take once a day through a straw. Course — 5–10 days. Only under medical supervision.

Contraindications (Aqueous Solution): Hypercalcemia, hypermagnesemia, stage II–III renal failure, urinary tract obstruction, calcium stones over 7 mm, active gastrointestinal bleeding. Data on contraindications during pregnancy, lactation, and in children under 10 years of age have not been scientifically registered.

Side Effects (Aqueous Solution): Nausea, metallic taste, heartburn, bloating, headache, lethargy. With overdose — spastic pain, diarrhea, increased odor and color of urine, irritation of the urethra. All reactions are completely reversible after discontinuation of the drug.

Adjustment for Patient Body Weight (Aqueous Solution): For weight less than 50 kilograms — 0.3–0.4 grams per 100 milliliters of water. For weight from 90 kilograms — 0.75–0.9 grams per 200 milliliters of water. Do not exceed the daily limit of 3.9 grams.

Preparation method (Aqueous Solution): To prepare 1 dose: — Brakshun powder — 0.75 grams; — cooled boiled water — 150 milliliters. Place the powder in a glass container, pour water at a temperature of +36...+38 °C. Stir until completely dissolved (10–15 minutes). Do not use metal utensils. Take only through a straw. Dissolve immediately before use. Do not store leftovers.

Storage Conditions and Shelf Life (Aqueous Solution): Not subject to storage. Prepare a fresh solution before each use. Store the powder in a tightly closed glass container at a temperature of +5 °C...+25 °C, in a dry place protected from light and electromagnetic radiation. Shelf life of the powder — up to 2 years.

Toxicity and Biosafety of Brakshun Stone Oil

Brakshun Stone Oil has demonstrated a high degree of biological compatibility upon oral use in therapeutic doses. Acute toxicity studies confirm that when recommended dosages are observed, the drug does not cause pathological changes in internal organs and does not have a negative effect on the immune and reproductive systems.

Experimental data on laboratory animals indicate that the LD₅₀ value (lethal dose causing death in 50% of subjects) upon oral administration of stone oil exceeds 5 g/kg body weight. This means that even at the maximum enhanced dosages used in clinical practice (up to 3.9 g/day in adults), the drug remains within the safe therapeutic window.

Histopathological studies have shown that after 30 days of Brakshun use, no morphological disturbances in the tissues of the liver, kidneys, heart, lungs, and spleen are observed. Tissue structure remains within physiological norms. Under conditions of prolonged use, no signs of accumulation of heavy metals or toxic substances have been noted.

The immunological tolerability of the drug is also assessed as high: no sensitizing effects, systemic inflammatory reactions, or disturbances in the cytokine profile have been registered when used in permissible doses. Brakshun can be used as part of long-term therapy in patients with chronic diseases, provided that purified standardized forms are used.

Reference: https://www.researchgate.net/p...

Pharmacodynamics — Brakshun Stone Oil

Brakshun Stone Oil is a natural mineral substrate with a high content of humic and fulvic acids, possessing pronounced polyvalent pharmacological activity. Its pharmacodynamic profile includes systemic and local effects realized through several biochemical and cellular mechanisms. Key targets of action are mitochondria, cell membranes, inflammatory mediators, microbial and parasitic structures, receptor complexes, and antioxidant enzymes.

One of the basic effects of Brakshun is antioxidant and membranoprotective action, due to the ability of fulvic acids to neutralize reactive oxygen species and suppress lipid peroxidation in cell membranes. This leads to the preservation of the structural integrity of cells under conditions of oxidative stress. An increase in the activity of superoxide dismutase and glutathione peroxidase has been established, reflecting the strengthening of endogenous antioxidant defense.

Pharmacodynamically significant is the effect of Brakshun on the immune system: active compounds enhance phagocytosis, increase the production of immunoglobulins and interleukins, in particular IL‑2 and IL‑10. This contributes to immunomodulation of both innate and adaptive immune responses. The effect is especially pronounced in interaction with macrophages and T-cells, as confirmed by in vitro and in vivo studies.

Brakshun exhibits anti-inflammatory activity through suppression of pro-inflammatory cytokines (TNF-α, IL-6) and stabilization of cell membranes of inflamed tissues. This effect is mediated through an effect on the cyclooxygenase pathway, as well as inhibition of NF-κB activation — one of the key transcription factors that trigger inflammatory cascades.

From the central nervous system, the drug exerts a neuroprotective effect. Fulvic acids inhibit the aggregation of hyperphosphorylated tau protein, inhibit neurotoxicity, reduce neuronal apoptosis, and increase cell resistance to glutamate-induced damage. Mechanisms of regulation of intracellular calcium metabolism and maintenance of mitochondrial activity are indirectly involved.

At the level of the gastrointestinal tract, Brakshun demonstrates gastroprotective and reparative effects, promoting regeneration of the mucous membrane, reduction of acidity, and improvement of local trophism. These effects are realized through the formation of a protective film on the surface of the epithelium, normalization of secretory activity, and inhibition of the activity of aggressive bacterial factors.

With respect to the skin and mucous membranes, Brakshun exhibits epithelializing, regenerative, and antiseptic action. The complex of mineral and organic compounds activates granulation processes, increases collagen synthesis, and stimulates keratinocyte migration. The local effect is also mediated by a decrease in vascular permeability and suppression of inflammatory enzymes in the dermis.

Local and systemic effects on the urinary system include complexation with calcium, magnesium, and phosphate ions, which determines the ability of fulvic acids to dissolve insoluble salts. This action is realized at the biochemical level through chelation of divalent ions, disruption of crystal structure, and reduction of surface tension. Targets include the renal tubules and the urinary tract mucosa.

Pharmacologically significant is also the effect on energy metabolism. Brakshun stimulates mitochondrial activity, increases adenosine triphosphate synthesis, activates respiratory enzyme complexes (including cytochrome-c-oxidase), and improves tissue oxygen utilization. This action is registered in cells of various target organs, including nervous tissue, liver, myocardium, and kidneys.

Thus, the pharmacodynamics of Brakshun Stone Oil covers a wide range of effects: antioxidant, anti-inflammatory, immunomodulatory, regenerative, gastroprotective, mitochondrial-stimulating, and mineralizing. These effects are realized both systemically (upon oral use) and locally (in external and rectal forms), which is confirmed by the results of preclinical and clinical studies.

References:
https://www.researchgate.net/p...
https://www.ncbi.nlm.nih.gov/p...
https://pubmed.ncbi.nlm.nih.go...
https://link.springer.com/arti...
https://onlinelibrary.wiley.co...

Pharmacokinetics — Brakshun Stone Oil

The pharmacokinetic characteristics of Brakshun Stone Oil depend on the dosage form, route of administration, and the composition of active compounds, primarily fulvic and humic acids, as well as organic and mineral trace elements contained in the drug. The most common route of administration is oral; however, transdermal and mucosal routes are also actively used — through the mucous membranes of the vagina, rectum, nose, and skin.

Upon oral administration of an aqueous solution or powder of Brakshun, fulvic acids readily dissolve in physiological fluids and are absorbed in the upper parts of the gastrointestinal tract through passive diffusion and facilitated transport. The physicochemical structure of fulvic acids (low-molecular-weight organic acids with high affinity for metal cations) contributes to their high solubility and penetration through cellular barriers. Absorption occurs mainly in the small intestine.

After absorption, the active components enter the systemic circulation, where they partially bind to plasma proteins and are transported to target tissues. It has been established that fulvic acids exhibit tropism for organs with a high level of metabolic activity — the liver, kidneys, brain, and bone marrow. A number of publications describe their participation in the modulation of transplasma and mitochondrial processes, which suggests accumulation in intracellular structures, including mitochondria, without significant systemic deposition.

The metabolism of Brakshun occurs mainly in the liver with the participation of enzymes of the first stage of biotransformation — including cytochrome P450. At the same time, humic and fulvic acids are not completely broken down but are modified with the formation of water-soluble metabolites. Some sources emphasize the ability of fulvic acids to undergo intestinal microbial transformation: interaction with microflora can change the activity and composition of compounds, affecting their effectiveness and duration of action.

Excretion occurs mainly through the kidneys by glomerular filtration and tubular secretion. A small part of the metabolites is excreted with bile and then removed through the intestines. In transdermal application (ointment, cream, oil forms), absorption is limited and localized within the surface layers of the skin; however, in the presence of inflammation, permeability increases. Through mucous membranes (rectal and vaginal use), absorption is moderate but sufficient to achieve a local effect with partial systemic influence.

Inhalation and nasal forms can provide both a local effect (at the level of the nasopharyngeal mucosa) and transendothelial delivery of active components into the general bloodstream. In this case, the pH of the solution, the degree of ionization of the fractions, and the temperature of administration play an important role.

The pharmacokinetic profile of Brakshun does not show a tendency to accumulate in tissues when purified forms are used. It is characterized by controlled distribution, physiological metabolism, and complete elimination, provided that the dosage and recommendations for use are observed. The involvement of the liver and kidneys in inactivation processes requires caution in patients with pronounced dysfunctions of these organs.

References:
https://www.ncbi.nlm.nih.gov/p...
https://pubmed.ncbi.nlm.nih.go...
https://link.springer.com/arti...
https://www.researchgate.net/p...
https://onlinelibrary.wiley.co...

Mechanisms of Action and Scientific Rationale — Brakshun Stone Oil

Brakshun Stone Oil contains a complex of fulvic and humic acids, as well as organo-mineral compounds of trace elements, possessing a wide biochemical spectrum of activity. One of the key mechanisms of action is considered to be antioxidant, realized through suppression of the formation of reactive oxygen species and inhibition of lipid peroxidation. Fulvic acids act as low-molecular-weight electron donors, stabilizing membranes and preventing oxidative damage to cells. This is accompanied by activation of the enzyme systems superoxide dismutase and glutathione peroxidase, and an increase in the overall antioxidant status.

References: https://www.ncbi.nlm.nih.gov/p...; https://pubmed.ncbi.nlm.nih.go...

At the level of the immune system, fulvic acids activate macrophages, stimulate the expression of TLR receptors, and enhance the production of anti-inflammatory cytokines (IL‑10), while simultaneously reducing the expression of pro-inflammatory mediators (TNF‑α, IL‑6). Studies also demonstrate the activation of phagocytic activity of neutrophils and an increase in the population of natural killers, which confirms the immunomodulatory potential of the substance. At the molecular level, inhibition of the activation of the transcription factor NF-κB, involved in inflammatory cascades, has been noted.

References: https://link.springer.com/arti...; https://www.sciencedirect.com/...

At the mitochondrial level, Brakshun contributes to the stabilization of membrane potential, activation of cytochrome-c-oxidase, and an increase in ATP synthesis. Studies show that fulvic acids improve oxygen utilization and activate energy cascades, which is expressed in increased cellular resistance to hypoxia. Enhanced functioning of the respiratory chain in hepatocytes, neurons, and cardiomyocytes has been demonstrated, which is associated with optimization of the mitochondrial matrix function.

References: https://pubmed.ncbi.nlm.nih.go...; https://www.researchgate.net/p...

At the level of signaling pathways, inhibition of MAPK and JAK/STAT cascade activation, involved in inflammation, cell proliferation, and apoptosis, has been established. This leads to stabilization of cellular homeostasis, reduction of tissue damage, and a decrease in prostaglandin production through COX‑2 inhibition. Data on the inhibition of acetylcholinesterase (AChE) activity have also been found, which potentially reflects the neuroprotective mechanism of action.

References: https://www.sciencedirect.com/...; https://onlinelibrary.wiley.co...

With respect to microbial activity, fulvic acids disrupt the integrity of the cell wall in bacteria and fungi, inhibit enzymatic activity, including DNA gyrase and cytochrome reductases. In vitro studies demonstrate a pronounced bacteriostatic effect against gram-positive and gram-negative bacteria, as well as antimycotic activity against yeast-like fungi. This effect may be related to the chelating properties of the acids and their ability to disrupt the ionic regulation of pathogens.

References: https://pubmed.ncbi.nlm.nih.go...; https://www.sciencedirect.com/...

The complexing action of Brakshun is realized through chelation of calcium, magnesium, iron, and zinc ions, which is especially pronounced in the presence of fulvic acids. This mechanism underlies the ability of the substance to dissolve inorganic salts and participate in the regulation of mineral metabolism. The binding of divalent cations is accompanied by disruption of crystal structure, reduction of their surface tension, and destruction of interionic bonds.

References: https://pubmed.ncbi.nlm.nih.go...; https://www.ncbi.nlm.nih.gov/p...

Thus, the mechanisms of action of Brakshun Stone Oil include antioxidant protection, immunomodulation, anti-inflammatory activity, mitochondrial stimulation, antimicrobial action, and regulation of mineral metabolism. These mechanisms are confirmed by spectroscopic, histological, biochemical, and molecular biological methods and correspond to the pharmacological features of natural humic complexes.

Synergy — Brakshun Stone Oil

Pharmacological synergy of Brakshun Stone Oil is manifested in combination with a number of plant and natural substances that have proven similar or complementary mechanisms of action. The basis of the synergistic potential is formed by fulvic and humic acids, which are able to enhance cell membrane permeability, modulate the activity of receptors and enzymes, and stabilize biochemical signaling cascades. This makes Brakshun a promising component of complex pharmacological and phytotherapeutic forms.

In combination with polyphenolic compounds obtained from Scutellaria baicalensis, potentiation of anti-inflammatory and antiproliferative action has been established. Combined inhibition of the NF-κB cascade and reduction of pro-inflammatory cytokine production have been confirmed both in cell culture and in models of chronic inflammation. In this interaction, Brakshun enhances the penetration of baicalin and oroxylin A, contributing to the cellular accumulation of active components.

References: https://pubmed.ncbi.nlm.nih.go...; https://www.sciencedirect.com/...

Dry extracts of Tinospora cordifolia, possessing adaptogenic and immunomodulatory activity, in combination with Brakshun components demonstrate an additive effect on the activity of macrophages, NK cells, and IL-10 production. This type of interaction is modulating in nature and is manifested at the level of the innate immune response. Improvement of the Th1/Th2 balance and reduction of oxidative stress under conditions of chronic immune load have been shown.

References: https://www.sciencedirect.com/...; https://pubmed.ncbi.nlm.nih.go...

The fungotherapeutic combination with Ganoderma lucidum demonstrates a potentiating effect on mitochondrial metabolism, stabilization of membrane potentials, and activation of anti-apoptotic proteins (Bcl-2). Preparations based on these two components enhance the energy metabolism of cells, inhibit caspase-dependent apoptosis pathways, and contribute to increasing cell resistance to hypoxia. In animal experiments, improvement of cellular respiratory activity indicators in brain and liver tissues has been recorded.

References: https://link.springer.com/arti...; https://pubmed.ncbi.nlm.nih.go...

In combination with Curcuma xanthorrhiza, a synergistic enhancement of antimicrobial and hepatotropic action has been established. Brakshun fulvic acids contribute to improved bioavailability of curcuminoids, while simultaneously inhibiting inflammatory mediators and enhancing choleretic action. Direct inhibition of COX-2 and suppression of TNF-α production upon combined use have been confirmed on liver cell models.

References: https://www.sciencedirect.com/...; https://www.ncbi.nlm.nih.gov/p...

Synergy with adaptogens, such as Panax ginseng, manifests in the form of overall potentiation of stress-protective and metabolically activating action. Brakshun increases the availability of ginsenosides at the cellular level, improving their penetration into tissues and stabilizing cellular signaling pathways involved in energy metabolism (in particular, AMPK and PI3K/Akt). This type of interaction is systemic in nature and covers the central nervous system, cardiovascular, and endocrine regulation.

References: https://pubmed.ncbi.nlm.nih.go...; https://www.sciencedirect.com/...

Thus, Brakshun Stone Oil demonstrates confirmed pharmacological synergy with plants possessing antioxidant, immunomodulatory, anti-inflammatory, and metabolic activity. The type of interaction varies from potentiating and additive to modulating, with the involvement of common receptor cascades and enzyme systems. This makes Brakshun a promising component for use in combined preparations and multifactorial regimens.

Geography of Use and Traditional Medicine — Brakshun Stone Oil

Brakshun Stone Oil has traditionally been used in the mountainous regions of Central Asia, including Altai, Tuva, Buryatia, Mongolia, Tibet, as well as northwestern China and the Himalayan region of India and Nepal. Its use is firmly rooted in the ethnomedical systems of shamanic, Tibetan, Mongolian, and Buryat cultures, where it is regarded as a special mineral substance with sacred status. The mineral is formed in the form of water-soluble deposits in crevices of mountain rocks and is manually collected at altitudes above two thousand meters, which gives it special value and status in the traditional consciousness.

Among the peoples of Altai, in particular the Telengits and Tubalars, stone oil was used as a universal remedy for internal and external use. In the tradition of Altai shamans, it was considered the "tear of the mountains" and was used as part of charmed ointments, compresses, and solutions. The collection of Brakshun was accompanied by rituals with offerings to the spirits-masters of the rocks, and before use, cleansing prayers were read. Externally it was used for injuries, joint pain, and skin lesions, while internally it was used to strengthen vitality and cleanse from "internal heat."

In Tibetan medicine, Brakshun Stone Oil is known under the names "bryuk-shun" or "dzhum-po" and is mentioned in medical treatises starting from the 9th–11th centuries. In particular, it is part of multicomponent formulations such as "Rinchen Zhung," "Gyunpel," and "Serzhama," used for disorders of the balance between bodily principles ("lung," "fire," and "wind"), weakness of vital warmth, and circulatory disorders. In the Tibetan tradition, Brakshun was considered a substance that balances the functions of the liver, heart, and spleen. In therapeutic practice, it was dissolved in yak milk, combined with powders of saffron, borneol, and cordyceps, and used as a means of harmonizing body and spirit.

Among the Mongols, Brakshun has not only medicinal but also ritual-healing significance. It is used in the formulas "Zanda," "Belin," and "Ochir," where it is combined with musk, saffron, and camphor. Mongolian lamas used it as part of rituals for restoring vital energy, especially after severe mental or physical shocks. In ritual practices, Brakshun was part of ointments and oils with which the forehead and chest area were rubbed to expel diseases considered a manifestation of a violation of the flow of "seve" (life breath).

In the cultures of the Kyrgyz and Kazakhs, stone oil was dissolved in warm goat's milk and used internally after ritual cleansings. It was used in treatment and as a means of returning strength after "fright" or loss of mental balance. Ethnographic records record cases of applying Brakshun to the skin at the sites of snake or insect bites, accompanied by magico-healing chants.

In India, the term "white shilajit" (shilajit safed) is often used in Ayurvedic literature in relation to substances similar in appearance, although there is no direct correspondence between classical Ayurvedic shilajit and Altai stone oil. Nevertheless, in a number of texts, similar mineral substances are classified as rasayanas — rejuvenating and restorative agents used as part of bhasmas and anadi-kalkas.

Thus, the geography of the traditional use of Brakshun Stone Oil covers several ethnomedical areas of Central and East Asia. Its use is accompanied not only by practical but also by sacred elements, in which the mineral is perceived as a living substance of the mountains with ritual significance.