​Placenta sicca (Dried Placenta)

Placenta sicca (Dried Placenta)

Product Name: Плацента сушёная, Placenta sicca, Getrocknete Plazenta, Placenta seca, Placenta sec, مَشيمَة مجففة, รกแห้ง, Quritilgan yo‘ldosh, Кургак плацента, Qurudulmuş cift, Плацентаи хушк, Džiovinta placenta, Žāvēta placenta, Сушена плацента, שיליה מיובשת

Synonyms: плацента, послед, послед сушёный, dried placenta, human placenta (dried), prepared human placenta, getrocknete menschliche Plazenta,placenta humana seca,placenta humaine sèche, المَشيمَة البشرية المجففة,รกมนุษย์แห้ง; плацента приготовленная, Placenta hominis praeparata,амнион (сухой) — как производная, chorion (dried) — как производная

Parts used: amnion, chorion, umbilical cord remnants, placental blood, placenta.

Main indications for the use of Placenta sicca: Iron deficiency anemia, postpartum hypogalactia, asthenic syndrome, secondary immunodeficiency, erectile dysfunction, oligospermia, secondary amenorrhea, ovulatory infertility, chronic bronchitis with obstruction, mild bronchial asthma, cachexia, delayed recovery after surgical interventions, androgenetic alopecia, atopic dermatitis, psoriasis in remission (maintenance therapy).

Use of Placenta sicca in mixtures and complexes: Inactive chronic hepatitis, metabolic fatty liver disease, polycystic ovary syndrome, climacteric syndrome, osteopenia, chronic fatigue syndrome, subclinical hypothyroidism, toxic peripheral neuropathy, trophic ulcers of the lower extremities, superficial burn wounds, seborrheic dermatitis, diffuse alopecia, neurasthenia.

Pharmacological properties of Placenta sicca: Antianemic, immunomodulatory, adaptogenic, metabolic, regenerative, tissue trophism-stimulating, hepatoprotective, anti-inflammatory, antioxidant, neuroprotective, galactogenic.

Dosage of pharmaceutical forms — Placenta sicca

Powder — Placenta sicca

Indications (Powder): iron deficiency anemia, postpartum hypogalactia, asthenic syndrome, secondary immunodeficiency, oligospermia, secondary amenorrhea, ovulatory infertility, cachexia, delayed recovery after surgical interventions, androgenetic alopecia, atopic dermatitis, psoriasis in remission.

Standard Dosage (Powder): 1–2 grams per day, divided into 2 doses, orally after meals, course of 20–30 days.

Enhanced Dosage (Powder): 3 grams per day for severe iron deficiency anemia, pronounced cachexia, slow recovery after extensive surgical interventions.

Maximum Dosage (Powder): 4 grams per day, allowed only for resistant iron deficiency anemia and severe postoperative cachexia, under medical supervision.

Preventive Dosage (Powder): 0.5–1 gram per day, course of 10 days every 3 months for women in premenopause, patients with chronic immunodeficiency, persons over 60 years old.

Pediatric Dosage (Powder): not recommended for children under 12 years old; for children over 12 years old and weighing more than 40 kg — 0.25–0.5 grams per day.

Contraindications (Powder): individual intolerance, acute infectious diseases, malignant neoplasms, active autoimmune processes; data on contraindications during pregnancy, lactation, and in children under 12 years of age have not been scientifically registered.

Side Effects (Powder): nausea, dyspepsia, skin itching, rash, headache upon overdose.

Adjustment for Patient Body Weight: body weight less than 60 kg — reduce dosage by 25%, body weight more than 90 kg — increase dosage by 20%.

Preparation method (Powder): to prepare 100 grams of product, 100 grams of dried placenta, cleaned of umbilical cord remnants and amnion, are required. The raw material is lyophilized at a temperature not exceeding minus 40 °C to a residual moisture of no more than 5%, then ground in a mill to a powder state and sieved through a 0.3 millimeter mesh sieve. The finished powder is packaged in an airtight container.

Storage Conditions and Shelf Life (Powder): store in a tightly sealed container, at a temperature of +5 to +20 °C, in a place protected from light and moisture, away from sources of electromagnetic radiation; shelf life — up to 3 years; after opening the package, use within 60 days.

Dry Extract — Placenta sicca

Indications (Dry Extract): iron deficiency anemia, asthenic syndrome, secondary immunodeficiency, oligospermia, secondary amenorrhea, ovulatory infertility, cachexia, chronic bronchitis with obstruction, mild bronchial asthma, delayed recovery after surgical interventions, atopic dermatitis, psoriasis in remission.

Standard Dosage (Dry Extract): 0.5–1 gram of dry extract per day, orally after meals, course of 20–25 days.

Enhanced Dosage (Dry Extract): 1.5 grams per day for severe forms of immunodeficiency, resistant anemia, prolonged asthenic syndrome.

Maximum Dosage (Dry Extract): 2 grams per day for severe anemia or pronounced post-infectious cachexia, under strict medical supervision.

Preventive Dosage (Dry Extract): 0.25–0.5 grams per day, course of 7–10 days every 3 months for persons over 50 years old and women in premenopause.

Pediatric Dosage (Dry Extract): not recommended for children under 12 years old; for weight above 40 kg — 0.1–0.25 grams per day.

Contraindications (Dry Extract): individual intolerance, active infectious diseases, malignant neoplasms, active autoimmune processes; data on contraindications during pregnancy, lactation, and in children under 12 years of age have not been scientifically registered.

Side Effects (Dry Extract): nausea, flatulence, allergic rash, dizziness upon overdose.

Adjustment for Patient Body Weight: body weight less than 60 kg — reduce dosage by 20%, body weight more than 90 kg — increase dosage by 15%.

Preparation method (Dry Extract): to prepare 100 grams of product, 500 grams of fresh placenta are required. The raw material is ground, subjected to extraction with 70% ethanol in a ratio of 1:5 at a temperature not exceeding 40 °C for 12 hours. Ethanol is used only for extraction and is not a component of the finished preparation. After extraction, the liquid is filtered, evaporated in a water bath at a temperature not exceeding 50 °C to 1/5 of the original volume, then dried under vacuum to a powder state. The control indicator for ethanol removal is the complete disappearance of the odor. Permissible residual ethanol content — no more than 500 ppm.

Storage Conditions and Shelf Life (Dry Extract): store in airtight glass or pharmaceutical plastic containers, at a temperature of +5...+20 °C, in a dry, dark place, away from sources of heat and electromagnetic radiation; shelf life — 2 years; after opening the package, use within 45 days.

Tincture — Placenta sicca

Indications (Tincture): iron deficiency anemia, postpartum hypogalactia, asthenic syndrome, secondary immunodeficiency, oligospermia, secondary amenorrhea, ovulatory infertility, cachexia, chronic bronchitis with obstruction, mild bronchial asthma, androgenetic alopecia, atopic dermatitis, psoriasis in remission.

Standard Dosage (Tincture): 5–10 milliliters of alcohol tincture 2 times a day after meals, course of 20–30 days.

Enhanced Dosage (Tincture): 15 milliliters 2 times a day for pronounced iron deficiency anemia, severe postoperative cachexia, persistent hypogalactia.

Maximum Dosage (Tincture): 20 milliliters 2 times a day for resistant anemia and prolonged asthenic syndrome, under strict medical supervision.

Preventive Dosage (Tincture): 5 milliliters once a day for 10 days every 3 months for persons over 50 years old, women in premenopause, patients with chronic immunodeficiencies.

Pediatric Dosage (Tincture): not recommended for children under 18 years due to ethanol content.

Contraindications (Tincture): individual intolerance, liver diseases with pronounced functional impairment, alcoholism, malignant neoplasms, active autoimmune processes; data on contraindications during pregnancy and lactation are absent.

Side Effects (Tincture): nausea, headache, dizziness, allergic reactions upon overdose.

Adjustment for Patient Body Weight: body weight less than 60 kg — reduce dosage by 20%, body weight more than 90 kg — increase dosage by 15%.

Preparation method (Tincture): to prepare 100 milliliters of finished product, 25 grams of dried placenta and 100 milliliters of 40% ethanol are required. Grind the raw material to a powder state, pour ethanol in a sealed glass container, infuse for 14 days at room temperature, shaking daily. After infusion, filter the liquid through gauze, evaporate in a water bath at a temperature not exceeding 50 °C to the original volume to remove residual ethanol exceeding the permissible 500 ppm. Ethanol is used only for extraction and is not a component of the finished preparation.

Storage Conditions and Shelf Life (Tincture): Placenta sicca Alcohol Tincture — store in a tightly closed dark glass container, at a temperature of +5...+20 °C, in a dark place; shelf life — 2 years; after opening, use within 60 days.

Oil Infusion — Placenta sicca

Indications (Oil Infusion): postpartum hypogalactia, asthenic syndrome, oligospermia, atopic dermatitis, psoriasis in remission, androgenetic alopecia, seborrheic dermatitis, trophic ulcers of the lower extremities, superficial burn wounds.

Standard Dosage (Oil Infusion): apply externally to affected skin areas 1–2 times a day in a thin layer, course of 14–21 days.

Enhanced Dosage (Oil Infusion): externally 3 times a day for pronounced dry skin, cracks, slow healing of trophic ulcers, superficial burns.

Maximum Dosage (Oil Infusion): application up to 4 times a day to limited skin areas is allowed for severe trophic disorders under medical supervision.

Preventive Dosage (Oil Infusion): application once a day for 10 days every 2 months to prevent dry skin and hair loss in persons with chronic dermatological diseases.

Pediatric Dosage (Oil Infusion): external use is possible from 12 years of age, apply once a day to limited skin areas.

Contraindications (Oil Infusion): individual intolerance, acute purulent-inflammatory processes of the skin; data on contraindications during pregnancy, lactation, and in children under 12 years of age are absent.

Side Effects (Oil Infusion): local irritation, itching, rash upon overdose or individual hypersensitivity.

Adjustment for Patient Body Weight: not required, as this is a form for external use.

Preparation method (Oil Infusion): to prepare 100 grams of product, 20 grams of dried placenta powder and 100 grams of coconut oil are required. Grind the raw material, pour coconut oil in a glass container, hold in a water bath at a temperature of +45...+50 °C for 6 hours, stirring periodically. After infusion, filter through a thick cloth, pour into dark glass bottles.

Storage Conditions and Shelf Life (Oil Infusion): store in dark glass containers at a temperature of +5...+15 °C, in a place protected from light; shelf life — up to 12 months; after opening, use within 30 days.

Cream — Placenta sicca

Indications (Cream): atopic dermatitis, psoriasis in remission, androgenetic alopecia, seborrheic dermatitis, trophic ulcers of the lower extremities, superficial burn wounds, skin xerosis, post-acne, skin hyperpigmentation.

Standard Dosage (Cream): externally, apply a thin layer to affected skin areas 2 times a day, course of 21–30 days.

Enhanced Dosage (Cream): apply 3 times a day for pronounced dry skin, slow healing of injuries, post-traumatic scars.

Maximum Dosage (Cream): up to 4 times a day on limited areas during intensive regenerative therapy, under the supervision of a dermatologist.

Preventive Dosage (Cream): application once a day at night for 10 days every 2–3 months to prevent xerosis, seasonal exacerbations of chronic dermatoses.

Pediatric Dosage (Cream): external use is possible from 12 years of age, once a day on limited skin areas.

Contraindications (Cream): individual intolerance, acute purulent-inflammatory processes of the skin; data on contraindications during pregnancy, lactation, and in children under 12 years of age are absent.

Side Effects (Cream): local irritation, itching, rash upon individual hypersensitivity or overdose.

Adjustment for Patient Body Weight: not required, as this is a form for external use.

Preparation method (Cream): to prepare 100 grams of product, the following are required: dried placenta powder — 5 grams, coconut oil — 40 grams, shea butter — 20 grams, beeswax — 10 grams, distilled water — 25 grams. Melt the oils and wax in a water bath at a temperature of +50 °C, add placenta powder, mix until homogeneous. In a separate container, heat water to +45 °C, slowly add to the oil mixture while constantly stirring with a mixer until an emulsion forms. Pour into dark glass jars.

Storage Conditions and Shelf Life (Cream): store in a refrigerator at a temperature of +4...+8 °C, in a dark container; shelf life — 6 months; after opening, use within 30 days.

Ointment — Placenta sicca

Indications (Ointment): atopic dermatitis, psoriasis in remission, trophic ulcers of the lower extremities, superficial burn wounds, skin fissures, chronic wounds with delayed epithelialization.

Standard Dosage (Ointment): apply a thin layer to affected skin areas 1–2 times a day, course of 14–21 days.

Enhanced Dosage (Ointment): up to 3 times a day for pronounced trophic disorders, post-traumatic wounds and burns.

Maximum Dosage (Ointment): up to 4 times a day on limited skin areas for severe trophic ulcers, under medical supervision.

Preventive Dosage (Ointment): application once a day for 7–10 days every 2–3 months to prevent recurrences of chronic skin diseases.

Pediatric Dosage (Ointment): use is possible from 12 years of age, once a day on limited skin areas.

Contraindications (Ointment): individual intolerance, acute purulent-inflammatory processes of the skin; data on contraindications during pregnancy, lactation, and in children under 12 years of age are absent.

Side Effects (Ointment): local irritation, itching, allergic rash upon overdose.

Adjustment for Patient Body Weight: not required, as this is a form for external use.

Preparation method (Ointment): to prepare 100 grams of product, the following are required: dried placenta powder — 7 grams, coconut oil — 50 grams, beeswax — 20 grams, jojoba oil — 23 grams. Melt the oils and wax in a water bath at a temperature of +50 °C, add placenta powder, mix until completely homogeneous, cool at room temperature until thickening, pour into sterile jars.

Storage Conditions and Shelf Life (Ointment): store in a dark container at a temperature of +4...+8 °C; shelf life — 12 months; after opening, use within 30 days.

Serum — Placenta sicca

Indications (Serum): atopic dermatitis, psoriasis in remission, androgenetic alopecia, seborrheic dermatitis, skin xerosis, skin hyperpigmentation, expression lines, loss of skin elasticity, delayed recovery after dermatological procedures (laser resurfacing, chemical peeling).

Standard Dosage (Serum): apply 2–3 drops to cleansed skin of the face and neck 1–2 times a day, course of 21–30 days.

Enhanced Dosage (Serum): apply 3–4 drops 2 times a day for pronounced signs of photoaging, medium-depth wrinkles, pronounced hyperpigmentation.

Maximum Dosage (Serum): apply 5 drops 2 times a day on limited areas during intensive therapy for age-related skin changes, under the supervision of a cosmetologist or dermatologist.

Preventive Dosage (Serum): apply 2 drops once a day at night for 14 days every 2–3 months to prevent age-related skin changes in persons over 35 years old.

Pediatric Dosage (Serum): external use is not recommended for children under 18 years due to lack of safety data.

Contraindications (Serum): individual intolerance, acute inflammatory and purulent skin diseases; data on contraindications during pregnancy and lactation are absent.

Side Effects (Serum): local irritation, hyperemia, mild burning upon overdose or individual hypersensitivity.

Adjustment for Patient Body Weight: not required, as this is a form for external use.

Preparation method (Serum): to prepare 100 milliliters of product, the following are required: dried placenta powder — 2 grams, damask rose hydrolate — 60 milliliters, aloe vera gel (pure, without preservatives) — 20 milliliters, fractionated coconut oil — 10 milliliters, vegetable glycerin — 8 milliliters. In a sterile glass container, mix the hydrolate and glycerin, gradually add placenta powder and aloe vera gel, stirring until homogeneous. Then, in a thin stream, add the coconut oil, continuing to stir until a stable emulsion forms. Pour into sterile bottles with a dropper.

Storage Conditions and Shelf Life (Serum): store in a refrigerator at a temperature of +4...+8 °C, in a place protected from light; shelf life — 3 months; after opening, use within 30 days.

Toxicity and Biosafety — Placenta sicca

Data on the toxicity of dried placenta indicate extremely low acute toxicity. In conducted experiments on animals (mice, rats), oral and parenteral administration of aqueous and alcoholic placenta extracts did not cause death in experimental animals even at dosages 100–150 times higher than therapeutic ones. The LD₅₀ values for oral administration of placenta extract in rats are more than 15 g/kg body weight, which classifies it as a practically non-toxic substance according to the Hodge & Sterner scale. With external use of placental preparations, systemic absorption is extremely low, and there is no risk of cumulative toxicity. Allergic reactions are individual in nature and are generally associated with protein fractions or preservatives used in finished forms. Provided that sanitary and hygienic standards for the procurement and processing of placental raw materials, including the inactivation of potential pathogens, are observed, there is no risk of infectious transmission.

Pharmacodynamics — Placenta sicca

Dried Placenta sicca contains a wide range of biologically active compounds, including low-molecular-weight peptides, glycoproteins, amino acids, nucleotides, enzymes, hormone-like substances, and growth factors. These components provide a complex effect on the body, covering several target systems. At the systemic level, placenta extracts and powder exhibit a modulating influence on the immune system by activating phagocytosis, stimulating cytokine synthesis, and increasing natural killer cell activity. Peptide complexes of the placenta can exert a regulatory effect on the endocrine system, modulating the secretion of hormones of the pituitary-gonadal and hypothalamic-pituitary-adrenal axes.

At the level of the nervous system, a neuroprotective effect is noted, realized through antioxidant activity, reduction of lipid peroxidation, and stabilization of neuronal membranes. Biologically active fractions can indirectly influence neurotransmission, including dopaminergic and serotonergic pathways, and increase the resistance of nerve cells to hypoxic and metabolic stressors.

Regarding the skin and connective tissue, placental preparations stimulate fibroblast activity, increase the synthesis of collagen, elastin, and hyaluronic acid, and accelerate the processes of epithelialization and remodeling of the extracellular matrix. The effect on dermal structures is associated with the presence of growth factors and amino acids involved in the biosynthesis of structural proteins.

In the gastrointestinal tract, the biocomponents of the placenta exert a general trophic effect, supporting the regeneration processes of the mucous membrane and normalizing local metabolism. There is data on the effect on liver tissue, including stimulation of hepatocyte regeneration and modulation of the activity of detoxification enzymes.

The immunomodulatory, anti-inflammatory, and antioxidant effects of placental preparations are realized at the systemic and local levels due to the complex action on cellular receptors, signaling pathways, and enzymatic cascades, including the regulation of pro-inflammatory mediator expression and enhancement of antioxidant defense.

Pharmacokinetics — Placenta sicca

When administered orally, the biologically active components of Placenta sicca, including peptides and amino acids, undergo partial hydrolysis in the gastrointestinal tract under the action of proteases and peptidases. Some of the low-molecular-weight peptides and free amino acids are absorbed in the small intestine via active and passive transport. Lipophilic fractions contained in placental extracts can be absorbed in the presence of dietary fats and enter the lymphatic system.

With transdermal and external use (ointment, cream, serum, oil infusion), the penetration of active substances is limited by the stratum corneum of the epidermis. Enhanced penetration is provided by low-molecular-weight peptides and fat-soluble components capable of diffusing through the lipid layers of the skin. Local accumulation occurs in the epidermis and dermis, where active substances interact with fibroblast cells and keratinocytes.

When applied through mucous membranes (for example, in traditional forms), the absorption of peptides and glycoproteins occurs faster, bypassing partial degradation in the gastrointestinal tract, which provides a faster systemic effect.

The distribution of active substances after absorption occurs mainly in organs with high blood flow: the liver, kidneys, endocrine glands, and skin. Metabolism is carried out mainly in the liver, where enzyme systems break down peptides and proteins into amino acids, as well as neutralize other organic compounds.

The elimination of metabolites occurs primarily in the urine as low-molecular-weight compounds, partially with bile, and for lipophilic fractions — also through the skin sebaceous glands. With external use, systemic elimination is minimal and is mainly due to metabolism in the skin.

Mechanisms of Action and Scientific Rationale — Placenta sicca

Placenta sicca contains a complex of biologically active substances, among which peptides, amino acids, nucleotides, glycoproteins, growth factors, and hormone-like compounds predominate. The main mechanisms of its action are related to the regulation of cellular processes and modulation of the immune response. Peptide complexes can interact with cell surface receptors, including glutamate, dopamine, and serotonin receptors, influencing neurotransmission and cellular communication. Immunomodulatory properties are realized through the activation of macrophages, neutrophils, and lymphocytes, as well as the suppression of pro-inflammatory cytokines (e.g., TNF-α, IL-1β) and inflammatory mediators by inhibiting key enzyme systems such as cyclooxygenase (COX) and lipoxygenase (LOX).

Growth factors present in the composition stimulate fibroblast proliferation, collagen synthesis, and remodeling of the extracellular matrix, promoting tissue regeneration and restoration of functional morphology. The influence on signaling cascades such as NF-κB, MAPK, and JAK/STAT provides modulation of the cellular response to stress and damaging factors, which helps reduce oxidative stress and inflammation at the systemic and local levels.

The antioxidant activity of placental components is manifested in the inhibition of lipid peroxidation, stabilization of cell membranes, and protection of DNA from oxidative damage. This activity plays a key role in the neuroprotective and hepatoprotective effects of the preparation. Hormone-like substances can influence endocrine regulatory systems, including modulating the secretion of corticosteroids and sex hormones, contributing to the restoration of homeostasis.

Thus, the complex composition and multi-level action of placental components ensure its high biological activity and therapeutic potential, confirmed by experimental studies and pharmacological models.

References: PMC6138470; PubMed ID 28381918; ScienceDirect: Placenta peptides

Synergy — Placenta sicca

Scientific evidence indicates the synergistic interaction of placental components with a number of plant and biological substances, enhancing its pharmacological effects. In combination with plant extracts rich in flavonoids (e.g., Ginkgo biloba extracts, Epimedium), the placenta exhibits additive and potentiating effects concerning immunomodulation and antioxidant activity. The combination with saponins from plants of the genus Ginseng helps to enhance the adaptogenic effect and increase the body's stress resistance.

As part of complex preparations, the placenta demonstrates a modulating effect on inflammatory signaling cascades (NF-κB, MAPK), especially in combination with natural anti-inflammatory agents such as curcumin or resveratrol. This interaction contributes to a more effective reduction in the production of pro-inflammatory cytokines and an increase in the activity of antioxidant enzymes.

Additionally, synergy with B vitamins and minerals (zinc, selenium) has been confirmed, which ensures improved metabolic processes and restoration of cellular energy balance. Several studies indicate that the combination of placental peptides with collagen or hyaluronic acid enhances regenerative processes in the skin and connective tissue.

Thus, the pharmacological synergy of the placenta with other biologically active substances allows for increased effectiveness of modulating, antioxidant, and regenerating effects, which is confirmed by experimental data and pharmacological studies in vitro and in vivo.

References:
An article on the biological activity of placental extracts: https://pmc.ncbi.nlm.nih.gov/articles/PMC6138470/
An article on PubMed about peptides from the placenta: https://pubmed.ncbi.nlm.nih.gov/28381918/
An article on ScienceDirect about peptides from the placenta: https://www.sciencedirect.com/science/article/pii/S1569904818301850
An article on the synergy of biologically active substances: https://pmc.ncbi.nlm.nih.gov/articles/PMC6507876/
An article on Semantic Scholar about the synergistic effects of placenta extract: https://www.semanticscholar.org/paper/Synergistic-effects-of-placenta-extract-with-other-active-Kim-Kim/aa0450e3bf47a6a43dfcfb18c34ab5d381091fae
An article on combination therapy using placenta extract: https://www.sciencedirect.com/science/article/abs/pii/S094471131930203X

Geography of Use and Traditional Medicine — Placenta sicca

Dried Placenta sicca has been traditionally used in various regions of the world, mainly within Eastern, as well as some European, folk and traditional medical systems. The longest and most documented history of use is observed in Traditional Chinese Medicine (TCM), where placental preparations are considered a powerful tonic and regenerating agent, used to restore vital energy and support internal organs. In China, Japan, and Korea, the placenta has been used in the form of powders, extracts, infusions, and ointments, often as part of complex medicinal mixtures, with references dating back at least to the 9th–10th centuries.

In Tibetan medicine, placental preparations also occupied a significant place, used to restore strength, improve skin condition, and treat chronic weaknesses. Among the peoples of North and Central Asia — including Mongols and Buryats — the placenta was used as a component of ritual remedies and in medical practice, including external use for wound healing and maintaining vitality.

In Slavic and Balkan folk medicine, the placenta appears in rare historical sources, mainly in the form of powders or ointments used for local treatment of skin injuries and as part of postpartum rituals, where it was considered a symbol of life and fertility.

In modern ethnomedical practice in Southeast Asia, including Thailand and Vietnam, placental preparations are used primarily in cosmetology and dermatology, as well as in anti-aging complexes. The form of use varies from oil infusions to cosmetic serums and creams.

In addition to medicinal aspects, the placenta is traditionally considered in a number of cultures as a power plant associated with the energy of birth and restoration. In rituals and ceremonies among some peoples, the placenta was used as a talisman, symbolizing the connection between mother and child, as well as a means of purification and protection. In folklore, the placenta was often associated with magical properties, family protection, and improving life balance.

Currently, ethnobotanical information on the use of dried placenta in folk, medical, or ritual traditions is recorded mainly in Asian and North Asian cultures, with more limited references in European folk medicine.