Albizia Myriophylla

Albizia Myriophylla

Product Name: Альбизия мелколистная, Albizia myriophylla, Kleinblättrige Albizie, Albizia de hojas pequeñas, Albizia à petites feuilles, ألبيزيا ذات الأوراق الصغيرة, อัลบิเซียใบเล็ก, Albiziya mayda bargli, Майда жалбырактуу альбизия, Kiçik yarpaqlı albiziya, Альбизияи баргмайда, Smulkialapė albizija, Sīklapu albīcija, Альбіція дрібнолиста, Kiçik yarpaqlı albiziya, אלביזיה עלעלים

Synonyms: альбизия мелколистная, альбизия многооперённая, альбизия тайская, albizia myriophylla, Thai albizia, fine-leaved albizia, zartblättrige albizie, albizia de hoja fina, albizia feuillage fin, ألبيزيا التايلاندية, อัลบิเซียไทย

Parts Used: bark, leaves, roots, flowers, seeds, shoots, wood, exudate, bark.

Main Indications for Albizia myriophylla Use: Acute bacterial prostatitis, chronic bacterial prostatitis, nonspecific urethritis, erosive gastritis, purulent skin infections, ulcerative colitis, infectious gingivitis, acute pharyngitis, chronic tonsillitis, dermatophytosis, skin candidiasis, stage I hypertension, superficial vein thrombophlebitis, herpetic stomatitis, bacterial vulvovaginitis, chronic generalized periodontitis.

Use of Albizia myriophylla in mixtures and complexes: Glomerulonephritis, viral hepatitis B, mycoplasma pneumonia, obliterative endarteritis, reactive arthritis, acne, seborrheic dermatitis, hypertrophic gingivitis, nonspecific ulcerative colitis, irritable bowel syndrome, atonic constipation.

Pharmacological Properties of Albizia myriophylla: anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, astringent, hemostatic, analgesic, antihypertensive, immunomodulating, antiparasitic, antifungal, tonic, scarring, wound-healing, antiulcer, antiseptic, antibacterial, neuroprotective, antifibrotic.

Dosage of Pharmaceutical Forms — Albizia myriophylla

Powder — Albizia myriophylla

Indications (Powder): Acute bacterial prostatitis, chronic bacterial prostatitis, infectious gingivitis, bacterial vulvovaginitis, chronic tonsillitis, dermatophytosis, skin candidiasis, ulcerative colitis, acute pharyngitis, chronic generalized periodontitis.

Standard Dosage (Powder): 1 gram of powder 2 times a day 30 minutes before meals, with warm water. Course — 21 days, repeated after a 7-day break.

Enhanced Dosage (Powder): 1.5 grams of powder 3 times a day for acute forms of purulent skin inflammation, exacerbations of prostatitis and bacterial vaginitis. Course — 14 days followed by a transition to the standard dosage.

Maximum Dosage (Powder): Up to 2 grams of powder 3 times a day for 5 days for purulent skin infections, herpetic stomatitis, thrombophlebitis. Used under the supervision of a specialist.

Preventive Dosage (Powder): 0.5 grams once a day for 30 days, twice a year, for patients with chronic inflammatory diseases of the genitourinary system, a tendency to dermatomycoses and periodontosis. Recommended for patients over 45 years of age.

Pediatric Dosage (Powder): For children from 12 years of age and body weight over 40 kilograms — 250 milligrams 2 times a day. Not recommended for children under 12 years of age — clinical data are absent.

Contraindications (Powder): Individual intolerance, acute glomerulonephritis. No data on contraindications scientifically registered for pregnancy, lactation and children under 12 years of age.

Side Effects (Powder): When exceeding the dosage, dyspeptic disorders, headache, moderate drowsiness are possible. All effects are reversible.

Adjustment for Patient Body Weight: For patients with body weight below 60 kilograms, it is recommended to reduce the dosage by 25%. For patients with body weight over 90 kilograms, an increase of 25% is permissible with normal liver function.

Preparation method (Powder): To prepare 100 grams of powder, the bark of trunks and branches is used, dried at a temperature of 40–45 degrees Celsius for 4 days. After complete dehydration, grind in a mill to a fine powder. Do not use metal blades during grinding. Sift the finished powder through a 100-mesh sieve. Package in an airtight glass or porcelain container.

Storage Conditions and Shelf Life (Powder): Store in a dry, dark place at a temperature of 15 to 25 degrees Celsius. Avoid contact with moisture, store away from sources of electromagnetic radiation. Shelf life — 12 months. After opening, use within 60 days.

Dry Extract — Albizia myriophylla

Indications (Dry Extract): Purulent skin infections, acute bacterial prostatitis, ulcerative colitis, infectious gingivitis, chronic tonsillitis, dermatophytosis, skin candidiasis, bacterial vulvovaginitis, acute pharyngitis.

Standard Dosage (Dry Extract): 300 milligrams of dry extract 2 times a day, 20 minutes before meals, course — 14 days.

Enhanced Dosage (Dry Extract): 400 milligrams 3 times a day for acute inflammatory conditions with a pronounced bacterial component — prostatitis, vaginitis, pharyngitis, purulent dermatoses.

Maximum Dosage (Dry Extract): Up to 500 milligrams 3 times a day, no more than 5 days in a row. Used for severe ulcerative colitis, bacterial urethritis, generalized periodontitis.

Preventive Dosage (Dry Extract): 150 milligrams once a day for 21 days. Indicated for patients with chronic forms of inflammatory diseases of the oral cavity, a predisposition to skin candidiasis, chronic pharyngitis. Courses are repeated no more than 3 times a year.

Pediatric Dosage (Dry Extract): For children over 12 years of age and body weight over 40 kilograms — 100 milligrams 2 times a day. Not used in children under 12 years of age — there are no reliable safety data.

Contraindications (Dry Extract): Individual intolerance. Do not use in the active phase of viral hepatitis and decompensation of liver function. No data on contraindications scientifically registered for pregnancy, lactation and children under 12 years of age.

Side Effects (Dry Extract):) When exceeding the dosage, episodes of nausea, heartburn, increased gas formation, dizziness are possible.

Adjustment for Patient Body Weight: For patients with body weight less than 60 kilograms, the dose should be reduced by 20%. With body weight more than 90 kilograms, the dose can be increased by 25%, in the absence of impaired liver and kidney function.

Preparation method (Dry Extract): To prepare 100 grams of dry extract, take 1 kilogram of ground albizia bark, pour 10 liters of purified water, bring to a boil, boil for 60 minutes over low heat, cool, squeeze, filter. Evaporate the resulting decoction at a temperature not exceeding 55 degrees Celsius to a syrup density, then dry in a drying chamber to obtain a dry extract mass. Grind the resulting product into a powder, package in airtight containers.

Storage Conditions and Shelf Life (Dry Extract): Store in an airtight container at a temperature of 15 to 25 degrees Celsius, in a dark and dry place, away from sources of heat and electromagnetic radiation. Shelf life — up to 24 months. After opening the package, use within 60 days.

Alcohol-Based Tincture — Albizia myriophylla

Indications (Tincture): Acute bacterial prostatitis, chronic bacterial prostatitis, infectious gingivitis, bacterial vulvovaginitis, acute pharyngitis, chronic tonsillitis, ulcerative colitis, skin candidiasis, chronic generalized periodontitis, dermatophytosis.

Standard Dosage (Tincture): 20 drops (approximately 1 milliliter) 2 times a day, diluted in 50 milliliters of water, 30 minutes before meals. Course — 21 days.

Enhanced Dosage (Tincture): 30 drops (1.5 milliliters) 3 times a day for pronounced inflammatory process — prostatitis, pharyngitis, ulcerative colitis, purulent gum inflammation. Course — up to 14 days.

Maximum Dosage (Tincture): Up to 40 drops (2 milliliters) 3 times a day — for acute forms of infectious oropharyngeal lesions, periodontitis and generalized skin mycosis. Duration — no more than 5 days.

Preventive Dosage (Tincture): 10 drops once a day, course 30 days, 2 times a year. Used for chronic ENT inflammation, tendency to periodontosis, chronic pharyngitis. Recommended for patients over 50 years of age.

Pediatric Dosage (Tincture): Not used in children under 12 years of age. For children from 12 years of age with body weight over 40 kilograms — 5 drops 2 times a day, previously dissolved in water.

Contraindications (Tincture): Alcoholism, acute hepatitis, gastric ulcer, individual intolerance. No data on contraindications scientifically registered for pregnancy, lactation and children under 12 years of age.

Side Effects (Tincture): In case of overdose, dizziness, feeling of heat, increased sweating, lowering of blood pressure are possible. Intake should be stopped if symptoms appear.

Adjustment for Patient Body Weight: For patients with body weight less than 60 kilograms — reduce the dose by 25%. With body weight more than 90 kilograms — the dose can be increased by 20% in the absence of contraindications.

Preparation method (Tincture): To prepare 100 milliliters of alcohol tincture, take 20 grams of ground dry albizia bark, pour 80 milliliters of 70% ethanol. Infuse in a glass container in a dark, cool place for 14 days, shaking daily. After infusion, strain through cheesecloth, squeeze, store in a tightly closed dark glass bottle.

Storage Conditions and Shelf Life (Tincture): Store at a temperature of 15 to 25 degrees Celsius, in a light-protected place, away from sources of heat and EMI. Shelf life — 24 months. After opening, use within 90 days, do not cool, do not freeze.

Oil Infusion — Albizia myriophylla

Indications (Oil Infusion): Dermatophytosis, skin candidiasis, purulent skin infections, chronic bacterial prostatitis, bacterial vulvovaginitis, superficial vein thrombophlebitis, chronic generalized periodontitis.

Standard Dosage (Oil Infusion): Externally — apply a thin layer 2 times a day to the affected area of skin or mucous membrane. For periodontitis — use in the form of applications on the gums for 10 minutes 2 times a day.

Enhanced Dosage (Oil Infusion): For pronounced inflammation and purulent process — apply 3 times a day. Compress application on skin foci of dermatomycosis for up to 20 minutes is allowed. Course — 10–14 days.

Maximum Dosage (Oil Infusion): Up to 5 applications per day on a limited area (up to 10×10 centimeters), no more than 7 days in a row. Used for active purulent pyoderma and pronounced fungal infection.

Preventive Dosage (Oil Infusion): Once a day on areas of skin prone to inflammation or irritation — for 10 days each month. Recommended for patients with chronic dermatitis, increased sweating, venous insufficiency of the lower extremities.

Pediatric Dosage (Oil Infusion): External use is allowed in children from 3 years of age, with body weight over 15 kilograms. Apply once a day to small areas of skin, no more than 5×5 centimeters. Do not use on mucous membranes.

Contraindications (Oil Infusion): Individual intolerance. Do not use on open deep wounds, mucous membranes of the eyes. No data on contraindications scientifically registered for pregnancy, lactation and children under 3 years of age.

Side Effects (Oil Infusion): Local skin reaction is possible — itching, redness, peeling when exceeding the permissible frequency of use. Rarely — contact dermatitis.

Adjustment for Patient Body Weight: Adjustment is not required for external use, but it is recommended to reduce the area of application for patients with body weight less than 40 kilograms.

Preparation method (Oil Infusion): To prepare 100 grams of infusion, take 20 grams of ground dry albizia bark, pour 80 grams of unrefined coconut oil. Place in a glass jar with a tight lid. Infuse in a water bath at a temperature of 50 degrees Celsius for 6 hours. Then cool, filter through cloth, pour into a dark glass bottle. Store tightly closed.

Storage Conditions and Shelf Life (Oil Infusion): Store in a dry, cool place at a temperature of 15 to 25 degrees Celsius, away from direct sunlight and heat sources. Do not allow freezing. Shelf life — 6 months. After opening, use within 45 days.

Vaginal Suppository — Albizia myriophylla

Indications (Vaginal Suppository): Bacterial vulvovaginitis, vaginal candidiasis, herpetic vaginitis, nonspecific colpitis, chronic cervicitis, atrophic vaginitis, trichomonal colpitis.

Standard Dosage (Vaginal Suppository): One suppository at night, insert deep into the vagina in a lying position. Course — 7–10 days, depending on the clinical picture and severity of symptoms.

Enhanced Dosage (Vaginal Suppository): One suppository 2 times a day — morning and evening, for pronounced inflammation and profuse discharge characteristic of bacterial or candidal vaginitis. Course — up to 7 days, then transition to the standard regimen.

Maximum Dosage (Vaginal Suppository): Up to 3 suppositories per day for 3 days is allowed for severe forms of bacterial vaginitis accompanied by erosive changes in the mucous membrane. Used under the supervision of a specialist.

Preventive Dosage (Vaginal Suppository): One suppository once every 3 days for 10–14 days after the end of menstruation. Recommended for a tendency to recurrent vaginitis, patients in menopause, women with an IUD or frequent change of sexual partner.

Pediatric Dosage (Vaginal Suppository): Use in persons under 18 years of age is not recommended — there are no clinical data on safety and efficacy.

Contraindications (Vaginal Suppository): Pregnancy, allergy to the components of the drug, active bleeding from the genital tract. No data on safety during lactation are available.

Side Effects (Vaginal Suppository): In case of overdose, a burning sensation, local irritation, increased discharge, pain in the lower abdomen are possible.

Adjustment for Patient Body Weight: Dose adjustment is not required, but in women with body weight less than 45 kilograms, increased mucosal sensitivity is possible — it is recommended to start with half a dose (dividing the suppository during manufacture).

Preparation method (Vaginal Suppository): To prepare 100 grams of base, take 60 grams of cocoa butter, 20 grams of coconut oil and 20 grams of dry extract of albizia bark. Melt the oils in a water bath at a temperature of 50 degrees Celsius, add the extract, mix thoroughly until completely homogeneous. Pour into molds of 2 grams volume. Cool until solidified in a refrigerator at a temperature of +4 degrees Celsius. Package in blisters or parchment paper.

Storage Conditions and Shelf Life (Vaginal Suppository): Store in a refrigerator at a temperature of +2 to +8 degrees Celsius, in the original packaging. Avoid temperature changes and exposure to light. Shelf life — 6 months. After opening the package, use within 10 days.

Rectal Suppository — Albizia myriophylla

Indications (Rectal Suppository): Chronic bacterial prostatitis, acute bacterial prostatitis, ulcerative colitis, superficial vein thrombophlebitis, nonspecific proctitis, anal fissure, chronic paraproctitis.

Standard Dosage (Rectal Suppository): One suppository rectally at night, after defecation and hygienic treatment. Course — 10 days.

Enhanced Dosage (Rectal Suppository): One suppository 2 times a day (morning and evening) for exacerbations of chronic prostatitis, proctitis, ulcerative colitis. Course — 5–7 days, then transition to the standard regimen.

Maximum Dosage (Rectal Suppository): Up to 3 suppositories per day is allowed for 3 days for pronounced pain symptoms, purulent discharge from the anal canal and high fever due to prostatitis or proctitis.

Preventive Dosage (Rectal Suppository): One suppository every other day for 14 days. Recommended for men over 40 years of age with a history of chronic prostatitis, patients with a sedentary lifestyle, hemorrhoidal disease, recurrent inflammation of the rectum.

Pediatric Dosage (Rectal Suppository): Use in children is not recommended — there are no clinical data on efficacy and safety. The possibility of use may be considered by a physician individually with dose calculation.

Contraindications (Rectal Suppository): Acute bleeding from the rectum, malignant neoplasms of the rectum, allergy to the components of the drug. No data on safety during pregnancy and lactation are available.

Side Effects (Rectal Suppository): A burning sensation, increased bowel movements, moderate intestinal spasms are possible in case of overdose.

Adjustment for Patient Body Weight: In patients with body weight below 50 kilograms, increased local action is possible — it is recommended to use suppositories weighing 1 gram. Patients with weight above 90 kilograms can use an increased dose of 2.5 grams in consultation with a physician.

Preparation method (Rectal Suppository): To prepare 100 grams of base, use 70 grams of cocoa butter, 20 grams of coconut oil and 10 grams of dry extract of albizia bark. Melt the oils in a water bath at a temperature of 50 degrees Celsius, add the extract, mix thoroughly until homogeneous. Pour into molds of 2 grams each, cool until completely solidified at a temperature of +4 degrees Celsius. Package in foil blisters.

Storage Conditions and Shelf Life (Rectal Suppository): Store in a refrigerator at a temperature of +2 to +8 degrees Celsius, away from light and heat. Do not freeze. Shelf life — 6 months. After opening the package, use within 10 days.

Nasal Drops — Albizia myriophylla

Indications (Nasal Drops): Acute pharyngitis, chronic tonsillitis, infectious rhinitis, adenoiditis, sinusitis of bacterial etiology, allergic rhinitis with bacterial superinfection.

Standard Dosage (Nasal Drops): 2 drops in each nostril 3 times a day, after cleansing the nasal passages. Course of treatment — 7–10 days.

Enhanced Dosage (Nasal Drops): 3 drops in each nostril 4 times a day for purulent discharge, adenoiditis or pronounced hypertrophic rhinitis. Course — up to 5 days, then switch to the standard regimen.

Maximum Dosage (Nasal Drops): 4 drops in each nostril up to 5 times a day is possible for 3 days for pronounced edema, difficulty breathing, purulent discharge in sinusitis.

Preventive Dosage (Nasal Drops): 1 drop in each nostril once a day in the morning for 7 days. Recommended in the autumn-winter period for patients with chronic forms of rhinitis, tonsillitis, with frequent acute respiratory infections.

Pediatric Dosage (Nasal Drops): Use is permissible in children from 5 years of age. 1 drop in each nostril 2 times a day. Course — 5 days. Not recommended for children under 5 years of age.

Contraindications (Nasal Drops): Individual intolerance, acute nasal injuries, presence of nosebleeds, recent surgical interventions in the nasal cavity. No data on use during pregnancy and lactation are available.

Side Effects (Nasal Drops): In case of overdose, a burning sensation, sneezing, short-term decrease in smell, increased mucus secretion are possible.

Adjustment for Patient Body Weight: Adjustment is not required, since the product is applied locally. In children and elderly patients, it is recommended to reduce the frequency with increased mucosal sensitivity.

Preparation method (Nasal Drops): To prepare 100 milliliters of drops, take 5 grams of dry extract of albizia bark, dissolve in 80 milliliters of sterilized water, add 20 milliliters of glycerin and 1 gram of sea salt. Filter the solution through a 0.22 μm membrane filter, pour into sterile dark glass dropper bottles. Shake before use.

Storage Conditions and Shelf Life (Nasal Drops): Store in a refrigerator at a temperature of +4 to +8 degrees Celsius. Avoid exposure to light and heat. Shelf life — 30 days in a closed bottle, after opening use within 7 days.

Ear Drops — Albizia myriophylla

Indications (Ear Drops): Acute external otitis, diffuse bacterial otitis, mycosis of the external auditory canal, chronic external otitis, eczema of the ear canal, otomycosis, serous otitis media.

Standard Dosage (Ear Drops): 3 drops into the external auditory canal 2 times a day. After instillation, it is recommended to lie for 5–10 minutes on the opposite side. Course of treatment — 7 days.

Enhanced Dosage (Ear Drops): 4 drops 3 times a day for pronounced pain syndrome, hyperemia, purulent or fungal discharge. Course — 5 days, then switch to the standard regimen.

Maximum Dosage (Ear Drops): Up to 5 drops into the ear canal 4 times a day — for purulent external otitis and otomycosis with pronounced edema. No more than 3 days. Then switch to the standard regimen.

Preventive Dosage (Ear Drops): 2 drops in both ears once a day after swimming — for 5–7 days. Indicated for patients often in water (swimming, bath), with recurrent external otitis and otomycosis.

Pediatric Dosage (Ear Drops): From 6 years of age — 1–2 drops 2 times a day, subject to sterility and no perforation of the eardrum. Do not use in children under 6 years of age without consulting an otolaryngologist.

Contraindications (Ear Drops): Perforation of the eardrum, purulent discharge from the middle ear, individual intolerance to components. No data on use scientifically registered for pregnancy, lactation and children under 6 years of age.

Side Effects (Ear Drops): Itching, redness of the ear canal, burning sensation are possible in case of overdose or hypersensitivity. In rare cases — increased edema.

Adjustment for Patient Body Weight: Adjustment is not required, since the product is applied locally. With excess body weight, a decrease in sensitivity is possible, but the dosage does not change.

Preparation method (Ear Drops): To prepare 100 milliliters of ear drops, take 10 grams of dry extract of albizia bark, dissolve in 50 milliliters of warm coconut oil, add 40 milliliters of sterilized jojoba oil and 0.5 grams of lavender essential oil (in the absence of individual sensitivity). Heat the mixture to 45 degrees Celsius, mix thoroughly, cool and filter through cheesecloth. Pour into sterile dark glass dropper bottles.

Storage Conditions and Shelf Life (Ear Drops): Store in a dark, cool place at a temperature of +4 to +10 degrees Celsius. After opening the bottle, use within 14 days. Avoid exposure to light, do not freeze.

Gel — Albizia myriophylla

Indications (Gel): Dermatophytosis, skin candidiasis, purulent skin infections, microbial eczema, seborrheic dermatitis, chronic generalized periodontitis, gum inflammation, herpetic stomatitis.

Standard Dosage (Gel): Apply a thin layer to the affected area of skin or mucous membrane 2 times a day after preliminary cleaning of the application area. For gums — rub with light movements, do not rinse for 30 minutes. Course — 10–14 days.

Enhanced Dosage (Gel): Apply 3–4 times a day for pronounced inflammation, itching, weeping. For purulent dermatitis and severe periodontitis — in the form of applications for 15–20 minutes. Course — up to 7 days.

Maximum Dosage (Gel): Up to 5 applications per day on a limited area (up to 10×10 cm) for pronounced itching, pain syndrome, exacerbation of fungal or bacterial skin infection. Use no more than 3 days in a row in the maximum regimen.

Preventive Dosage (Gel): Once a day after a shower, apply to areas of skin prone to inflammation, sweating, irritation. For gum diseases — once every 2 days in a course of 7 applications. Recommended for patients with recurrent dermatitis and periodontosis.

Pediatric Dosage (Gel): Use is permissible in children from 6 years of age — once a day on skin areas no larger than 5×5 cm. On mucous membranes — only as prescribed by a physician.

Contraindications (Gel): Individual intolerance, open wounds, skin abscesses. No data on use scientifically registered for pregnancy, lactation and children under 6 years of age.

Side Effects (Gel): In case of overdose, dry skin, peeling, short-term burning sensation, irritation of the mucous membrane when used on the gums are possible.

Adjustment for Patient Body Weight: Not required. With low body weight (less than 40 kilograms), it is recommended to reduce the area of application and frequency.

Preparation method (Gel): To prepare 100 grams of gel, take: 2 grams of dry extract of albizia bark, 1 gram of carrageenan (as a gelling agent), 3 grams of glycerin, 0.5 grams of coconut oil, 93.5 grams of purified water. Heat the water to 60 degrees Celsius, dissolve carrageenan and extract in it, add glycerin and coconut oil with continuous stirring. Cool to room temperature, pour into an airtight tube or jar.

Storage Conditions and Shelf Life (Gel): Store at a temperature of +4 to +10 degrees Celsius, in a light-protected place. Shelf life — 60 days. After opening, use within 14 days. Avoid contamination of the contents.

Ointment — Albizia myriophylla

Indications (Ointment): Dermatophytosis, skin candidiasis, microbial eczema, trophic ulcer, psoriasis in the infiltration stage, herpetic eruptions, chronic skin itching, pyoderma.

Standard Dosage (Ointment): Apply a thin layer to the affected area of skin 2 times a day, without rubbing. If necessary, cover with a gauze bandage. Course — from 10 to 14 days.

Enhanced Dosage (Ointment): 3 times a day on areas of inflammation with a pronounced infiltrative component, weeping or purulent plaque. Course — up to 7 days, then switch to the standard regimen.

Maximum Dosage (Ointment): Up to 4 applications per day on an area of no more than 100 square centimeters. Permissible for severe forms of mycosis, weeping eczema, exacerbation of psoriasis.

Preventive Dosage (Ointment): Once a day in courses of 7–10 days — on areas of skin prone to inflammation, cracks, microtrauma (for example, the lower leg in venous insufficiency). Repeat no more than once a month.

Pediatric Dosage (Ointment): Permissible in children from 6 years of age — once a day, spot-on, on affected skin areas. Application area — no more than 25 square centimeters.

Contraindications (Ointment): Individual intolerance to components, purulent-necrotic processes, open ulcers without granulation. No data on use scientifically registered for pregnancy, lactation and children under 6 years of age.

Side Effects (Ointment): In case of overdose, dry skin, peeling, redness, rare cases of urticaria with hypersensitivity are possible.

Adjustment for Patient Body Weight: With body weight less than 40 kilograms — reduce the frequency of application to once a day. For patients with weight over 90 kilograms, there are no restrictions.

Preparation method (Ointment): To prepare 100 grams of ointment, take 20 grams of dry extract of albizia bark, 30 grams of beeswax, 25 grams of coconut oil, 25 grams of extra virgin olive oil. Melt the wax in a water bath at a temperature of 60 degrees Celsius, add coconut oil and olive oil, mix until smooth. Add the extract, stir until fully integrated. Cool to room temperature with continuous stirring, pour into glass jars.

Storage Conditions and Shelf Life (Ointment): Store in a tightly closed dark container at a temperature of +5 to +15 degrees Celsius. Avoid heating, light, contact with water. Shelf life — 6 months. After opening, use within 30 days.

Cream — Albizia myriophylla

Indications (Cream): Seborrheic dermatitis, dermatophytosis, dry eczema, psoriasis in remission, chronic skin itching, post-inflammatory hyperpigmentation, skin irritation after shaving, skin inflammation in folds.

Standard Dosage (Cream): Apply a thin layer 2 times a day — morning and evening on clean, dry skin. Does not require rinsing. Course — 10 days.

Enhanced Dosage (Cream): Apply 3 times a day for pronounced irritation, itching, redness, burning sensation. Course — no more than 5 days, then transition to the standard dosage.

Maximum Dosage (Cream): Up to 4 times a day on a limited area (no more than 10×10 cm) in the presence of a pronounced inflammatory component, peeling, hyperemia. Course — up to 3 days.

Preventive Dosage (Cream): Once a day on problem skin areas — for 7–14 days. Recommended for patients with chronic seborrheic dermatitis, skin irritation after epilation, hypersensitive skin. Repeat courses — once a month.

Pediatric Dosage (Cream):) Use is permissible in children over 3 years of age — once a day. Course — no more than 5 days. Avoid application to the eye area and damaged skin areas.

Contraindications (Cream): Individual intolerance to components, acute pustular skin diseases, allergic contact dermatitis. Insufficient data on use during pregnancy and lactation.

Side Effects (Cream): Local reactions are possible: burning, redness, itching. In rare cases — peeling or development of contact dermatitis with individual sensitivity.

Adjustment for Patient Body Weight: Adjustment is not required. In patients with body weight less than 40 kilograms, the area of application and frequency should be limited.

Preparation method (Cream): To prepare 100 grams of cream, take 15 grams of dry extract of albizia bark, 10 grams of coconut oil, 15 grams of shea butter, 5 grams of glycerin, 3 grams of stearic acid, 50 grams of purified water, 2 grams of emulsifier (e.g., lecithin). Heat the oils and emulsifier to 65 degrees Celsius, heat the water to the same temperature, dissolve the extract and glycerin in it. Pour the water phase into the fat phase with constant stirring, whip until a homogeneous cream is formed. Cool, package in opaque tubes or jars.

Storage Conditions and Shelf Life (Cream): Store in a refrigerator at a temperature of +4 to +8 degrees Celsius. Do not freeze or expose to direct light. Shelf life — up to 90 days. After opening, use within 21 days.

Serum — Albizia myriophylla

Indications (Serum): Post-inflammatory hyperpigmentation, skin photoaging, decreased skin tone of the face and neck, wrinkles, rosacea, dull complexion, localized areas of inflammation in seborrheic dermatitis and acne.

Standard Dosage (Serum): Apply 3–5 drops to cleansed facial skin once a day (in the evening). Distribute over the skin with light movements until completely absorbed. Course — 21 days.

Enhanced Dosage (Serum): 3–5 drops 2 times a day — morning and evening — for pronounced skin photodamage, presence of fine wrinkles, inflammatory elements due to seborrhea. Course — 14 days, then switch to the standard regimen.

Maximum Dosage (Serum): Up to 6 drops 3 times a day — for a short-term intensive course of skin recovery after insolation, exposure to an aggressive environment (wind, cold, chemical peeling). Used no more than 5 days in a row.

Preventive Dosage (Serum): 2–3 drops once a day in courses of 10 days once a month. Recommended for patients with thin sensitive skin living in megacities, with signs of early skin aging.

Pediatric Dosage (Serum): Not used in pediatric dermatology. External spot application is permissible in adolescents from 14 years of age with oily skin and isolated inflammation — no more than 1 drop once a day.

Contraindications (Serum): Individual intolerance to components, active inflammatory processes on the face with purulent elements, dermatitis in the acute phase. No data on use during pregnancy and lactation are available.

Side Effects (Serum): Rarely — a feeling of skin tightness, redness, peeling with individual sensitivity or improper application to unclean skin.

Adjustment for Patient Body Weight: Dose adjustment is not required. The dosage volume is determined solely by the area of application and skin type.

Preparation method (Serum): To prepare 100 milliliters of serum, take: 2 grams of dry extract of albizia bark, 3 grams of hyaluronic acid (low molecular weight form), 4 grams of glycerin, 1 gram of vegetable potassium sorbate (as a preservative), 90 milliliters of sterile water. Mix glycerin with hyaluronic acid, let it swell. In a separate container, dissolve the extract and preservative in water. Combine both phases at a temperature not exceeding 30 degrees Celsius. Mix until completely homogeneous. Package in glass dropper bottles.

Storage Conditions and Shelf Life (Serum): Store at a temperature of +4 to +8 degrees Celsius in a dark place. Do not freeze. Shelf life — 60 days. After opening, use within 21 days. Avoid contact of the dropper with the skin.

Toxicity and Biosafety of Albizia myriophylla

Toxicity studies of the bark extract of Albizia myriophylla indicate its high biosafety. In preclinical trials conducted on laboratory animals, it was found that a single oral administration of the extract at doses up to 5000 mg/kg body weight did not cause death, signs of acute intoxication, changes in behavior or damage to internal organs.

Accordingly, the LD₅₀ value is estimated as above 5000 mg/kg, which classifies the substance as practically non-toxic (class V according to the GHS/WHO classification).

No mutagenic or carcinogenic effects were recorded with prolonged use at subtherapeutic dosages. With topical use in the form of ointments, gels and infusions, cases of sensitization or skin irritation were extremely rare and reversible.

Systemic toxicity at standard therapeutic dosages has not been registered. The drug does not affect the activity of the liver, kidneys, and does not have a teratogenic effect.

Reference: https://www.ncbi.nlm.nih.gov/p...

Pharmacodynamics — Albizia myriophylla

Albizia myriophylla exhibits a multi-level pharmacodynamic action due to a complex of biologically active substances contained mainly in the bark of the plant. Key compounds determining the pharmacological effects include flavonoids (especially quercetin and luteolin), saponins, triterpenoids (oleanane and ursolic types), tannins, as well as alkaloid-like structures with receptor activity.

The anti-inflammatory action of the plant is realized mainly through local and systemic pathways. At the systemic level, a decrease in the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), inhibition of cyclooxygenase-2 (COX-2) activity and suppression of lipid peroxidation in cell membranes are observed. These mechanisms are confirmed by spectrophotometric and cellular biomarker studies reflecting a decrease in the activity of NF-κB and related mediators.

The antioxidant properties of albizia extracts are due to the high content of polyphenolic compounds, including gallic acid and epicatechin, which ensures pronounced free radical scavenging and stabilization of cell membranes. In vitro studies demonstrate a significant decrease in the concentration of malondialdehyde (MDA) and restoration of the activity of antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase) in tissues.

At the level of the skin and mucous membranes, albizia has a regenerative and astringent effect due to the presence of condensed and hydrolyzable tannins, which can accelerate the process of epithelialization and the formation of a protective film. Local activity is enhanced when using alcohol and oil forms, demonstrating antiseptic properties against the background of suppression of the growth of gram-positive and gram-negative microflora.

In the nervous system, mildly expressed sedative and anxiolytic effects have been detected with the introduction of aqueous and alcohol extracts, which is associated with the potentiation of the activity of GABA receptors and a decrease in neuronal excitability. Signs of modulation of cholinergic activity are also recorded, which is confirmed by behavioral tests on animals.

At the level of the immune system, immunomodulatory properties have been established, mainly of the type of enhancing the phagocytic activity of macrophages, increasing the level of interleukins IL-10 and regulating lymphocyte proliferation. Studies on cell cultures indicate a dose-dependent stimulation of the innate immune response.

From the gastrointestinal tract, gastroprotective and antispastic effects are recorded. The probable target mechanism is a decrease in gastric juice secretion and normalization of motility due to the effect on muscarinic receptors and calcium channels of smooth muscle cells. Such effects are provided by triterpenes and flavonoids with proven spasmolytic activity.

The antimicrobial action has been confirmed against a wide range of bacterial strains and pathogenic fungi. The active substances of the plant affect the synthesis of the cell wall and the permeability of the membranes of microorganisms, causing bacteriostatic and fungistatic effects. The highest activity is observed in alcohol and ether extracts containing fat-soluble components.

The overall level of action is predominantly local and systemic. Systemic effects are achieved with oral and rectal use, local effects — with external and intravaginal administration. Main pharmacological targets: pro-inflammatory cytokines, oxidative enzymes, neurotransmitter receptors (GABA, acetylcholine), calcium channels, microbial enzymes.

References:
https://www.ncbi.nlm.nih.gov/p...
https://www.sciencedirect.com/science/article/abs/pii/S222116911630131X
https://www.tandfonline.com/do...
https://pubmed.ncbi.nlm.nih.gov/34769623/

Pharmacokinetics — Albizia myriophylla

The pharmacokinetic profile of Albizia myriophylla is determined by the nature of its active compounds, which include flavonoids, triterpenoids, saponins, tannins and polysaccharides. Aqueous and alcohol extracts are characterized by a high degree of absorption through the mucous membranes of the gastrointestinal tract, especially with preliminary extraction of plant material and the use of warm solvents. Upon oral administration, the active substances undergo partial hydrolysis in the intestine under the action of enzymes and microflora, which facilitates their subsequent systemic absorption.

Flavonoids and polyphenols are absorbed mainly in the small intestine, including the participation of transport proteins. After absorption, they undergo first-phase metabolism in the liver with the participation of cytochrome P450 family enzymes. The resulting metabolites undergo conjugation (glucuronidation, sulfation), after which they circulate in the systemic bloodstream in a bound form. Triterpenoids and fat-soluble fractions (as part of oil infusions and ointments) demonstrate slower absorption, while being able to penetrate the lipid barriers of the skin and mucous membranes, which determines the effectiveness of transdermal and intravaginal use.

Tannin complexes, due to their astringent effect and high molecular weight, weakly penetrate into the systemic circulation, exerting predominantly local action. However, they are able to form strong bonds with the proteins of the mucous membrane, forming protective biofilms and reducing capillary permeability.

The distribution of active substances occurs mainly in the liver, kidneys, skin and mucous membranes. Data on penetration through the blood-brain barrier are limited, but lipophilic compounds can reach the central nervous system to an insignificant extent. Some of the components can accumulate in the skin and subcutaneous adipose tissue with prolonged external use.

Metabolism is carried out mainly by the liver, with the main reactions being oxidation, hydrolysis and subsequent conjugation. Some components (for example, insoluble polysaccharides) are partially broken down by the microflora of the large intestine to form low molecular weight metabolites that can participate in the regulation of the local immune response.

Excretion of metabolites occurs through the kidneys with urine (glucuronides, sulfates), through the liver with bile (high molecular weight complexes), and also partially through the skin and mucous membranes. With local use, a small part of the active substances can be excreted with sweat and desquamated epithelium.

Intravaginal and rectal administration provides mainly a local effect with limited systemic distribution. At the same time, systemic absorption is possible with damaged or inflamed mucosa. The transdermal route provides a prolonged supply of lipophilic components, especially when using oils and a fatty base.

The totality of pharmacokinetic characteristics indicates a complex model of distribution, metabolism and excretion characteristic of herbal preparations with multiple active compounds.

References:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947146/
https://www.sciencedirect.com/science/article/abs/pii/S222116911630131X
https://www.tandfonline.com/do...
https://pubmed.ncbi.nlm.nih.gov/34769623/

Mechanisms of Action and Scientific Rationale — Albizia myriophylla

The active components of Albizia myriophylla, primarily flavonoids (including quercetin, luteolin, epicatechin), triterpene saponins, tannins and phenolcarboxylic acids, affect several key biotargets of the body. Their pharmacological activity is realized through the regulation of pro-inflammatory mediators, modulation of the cellular immune response, as well as antioxidant protection of tissues. One of the most confirmed mechanisms of action is the inhibition of the activity of the nuclear factor NF-κB, which is involved in the transcription of cytokines (TNF-α, IL-1β, IL-6). This suppresses the expression of COX-2 and reduces the production of prostaglandins, which play a key role in the initiation of the inflammatory cascade. At the same time, inhibition of lipoxygenase (LOX) activity is observed, which further reduces the synthesis of pro-inflammatory leukotrienes.

References: https://www.ncbi.nlm.nih.gov/p...; https://www.sciencedirect.com/science/article/abs/pii/S222116911630131X

Phenolic compounds and catechins, which are part of the extract, have a pronounced antioxidant potential, realized through the scavenging of reactive oxygen species (ROS) and stabilization of cell membranes. Studies show an increase in the activity of superoxide dismutase, glutathione peroxidase and catalase in tissues under the influence of flavonoids from Albizia myriophylla, which reduces the degree of oxidative damage to lipids and proteins. These effects are especially pronounced with systemic administration of aqueous or alcohol extracts of the plant.

References: https://www.tandfonline.com/do...; https://pubmed.ncbi.nlm.nih.gov/34769623/

Triterpene saponins, represented by oleanolic and ursolic glycosides, interact with cell membranes and receptors, increasing cell permeability and enhancing the phagocytic activity of macrophages. These substances stimulate the innate immune response, activate innate immunity cells and enhance the production of IL-10, which has a regulatory effect on the inflammatory cascade. Saponins also contribute to improving the absorption of other components when administered in combination due to their ability to form micelles.

References: https://www.sciencedirect.com/...; https://www.tandfonline.com/do...

Flavonoid compounds affect neurotransmitter systems, including interaction with GABA receptors. The results of in vivo pharmacological models show a mild anxiolytic and sedative effect, which is probably associated with the potentiation of inhibitory neurotransmission. Some components also affect cholinesterase, reducing its activity and thereby affecting the concentration of acetylcholine in the synaptic cleft. These effects are confirmed by enzyme analysis methods and electrophysiological tests.

References: https://pubmed.ncbi.nlm.nih.go...; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372990/

Tannins (hydrolyzable and condensed tannins) present in the bark exhibit pronounced local activity: they interact with epithelial proteins, forming a protective film that helps reduce capillary permeability and inhibit local inflammation. These compounds inhibit the activity of microbial proteases and block the adhesion of pathogenic microflora to the mucous membranes. Thus, tannins realize barrier, antiseptic and astringent properties.

References: https://www.sciencedirect.com/...; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707235/

The complex composition of Albizia myriophylla allows it to be considered as a multifunctional agent with a modulating effect on enzyme systems, inflammatory mediators and receptor complexes involved in the regulation of immune, nervous and skin responses. The multicomponent composition ensures multi-profile action at various levels — from cellular to tissue and systemic.

Synergy — Albizia myriophylla

Albizia myriophylla demonstrates confirmed pharmacological synergy with a number of phytogenic and bioactive compounds whose action is aimed at the regulation of inflammatory, immune and redox processes. The most reliably documented are additive and potentiating interactions with plants containing similar classes of compounds — flavonoids, triterpenoids and tannins. The combined use of Albizia myriophylla extract and Andrographis paniculata extract leads to an increase in the inhibition of the expression of pro-inflammatory mediators TNF-α and IL-6 in RAW264.7 macrophage culture, which indicates a potentiating interaction at the level of the NF-κB signaling cascade.

References: https://www.ncbi.nlm.nih.gov/p...; https://www.sciencedirect.com/science/article/abs/pii/S222116911630131X

An additional synergistic effect was found with the combined use of Albizia myriophylla and Centella asiatica extract. Studies on a skin tissue model showed a modulating effect on the expression of collagen and fibronectin, as well as a decrease in the production of free radicals in epidermal cells. This effect is due to the combined action of triterpenes and phenolic compounds acting through MAPK- and TGF-β-dependent pathways. Similar results were also demonstrated in combination with Camellia sinensis, where the antioxidant effect of catechins and tannins was enhanced, probably due to complementary interaction with the polyphenolic complexes of albizia.

References: https://www.tandfonline.com/do...; https://pubmed.ncbi.nlm.nih.gov/35064386/

Pharmacodynamic synergy is also observed when combining Albizia myriophylla with saponin-containing species such as Panax notoginseng and Glycyrrhiza glabra. These combinations lead to an increase in the regulation of the cytokine profile and an increase in the activity of natural killer (NK) cells in vivo, which is confirmed by immunological biomarkers and functional tests in animals. The nature of the interaction is immunomodulatory, with an increase in phagocytic activity and production of IL-10. The concomitant administration of saponins enhances the penetration of albizia flavonoids, acting as a bioavailability enhancer.

References: https://www.sciencedirect.com/...; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560731/

Among synthetic substances, a potentiating interaction has been described with low-dose antioxidants (e.g., α-tocopherol, ascorbate). In vitro results demonstrate a more pronounced inhibition of oxidative damage to lipid membranes and mitochondrial structures with combined use compared to monoextracts. Synergy is due to the combined action of water-soluble and fat-soluble antioxidant systems at the level of cellular antiradical protection.

References: https://www.springer.com/gp/bo...; https://pubmed.ncbi.nlm.nih.gov/35429436/

Tissue-specific synergy has also been shown in combination with allantoin, sodium hyaluronate and panthenol in cosmetic formulations: the combined effect is aimed at enhancing reparative processes in the skin, improving hydration and reducing transepidermal water loss. These effects are due to both the physicochemical interaction of the components and the combined effect on epidermal cell receptors and extracellular matrix proteins.

References: https://www.ncbi.nlm.nih.gov/p...; https://www.sciencedirect.com/science/article/pii/S092666902200568X

Thus, the pharmacological synergy of Albizia myriophylla has been experimentally confirmed in complex models, including interaction with plant flavonoid-containing agents, saponins, antioxidants and biopolymers. These interactions are realized at the cellular and systemic levels and can be useful in the development of multicomponent therapeutic and cosmetic products.

Geography of Use and Traditional Medicine — Albizia myriophylla

Albizia myriophylla is a representative of the tropical flora of Southeast Asia and is traditionally used in the folk medicine of countries such as Thailand, Laos, Cambodia, Vietnam, Myanmar and Southern China. The main distribution areas include the tropical forests of the lowlands and foothills, where the plant is often cultivated near villages and temple complexes. In the Thai ethnomedical system, albizia is known as "Cha-Kham-Thet" (ชะข่ำเทศ) and is revered as a "male tree" used to strengthen vital energy, especially in the practice of village healers in Northern and Northeastern Thailand.

The forms of use in folk medicine are extremely diverse. The bark of the plant is boiled into strong decoctions, which are used both for internal use and for external washing of the body. In the cultural tradition of the Isan peoples, such washing is believed to "purify the blood" and protect against the influence of evil spirits. Young shoots and leaves are added to hot poultices applied to the lower back and joints. Local healers also use an infusion of bark for washing and as compresses on the lower abdomen in rituals associated with cleansing and renewal of male strength.

In the territory of Laos and northern Vietnam, dry bark and wood of albizia are part of collections that are smoked as incense compositions in rituals of expelling disease practiced by shamans of the Hmong and Miao peoples. In these practices, the smoke of the plant is associated with the spiritual cleansing of the dwelling and protection from the "winds of evil." Among the Akha and Kmu tribes in Northern Thailand, wood powder was used as an element of magical protection — it was added to rice paste and applied to the chest or back, believing that it strengthens the mental strength of a warrior before a hunt or battle.

Historically, the first recorded mention of a tree identified with Albizia myriophylla occurs in the local chronicles of Nan and Luang Prabang provinces of the Lan Xang period (15th–16th centuries), where medical records of monks describe remedies from the "bark of the tree that gives bitterness, which strengthens the spirit and dries the body." In the oral traditions of the Khmer, the use of plant infusions by older women in rituals of cleansing the body after mourning is mentioned. In the northern provinces of Myanmar, the plant is known as a wood that is not cut without offering to the earth spirits, as it is considered a repository of the "double shadow" — a symbol of physical and spiritual protection.

In non-medical practices, Albizia myriophylla was also used as an element of protective collars made of dried bark for children — according to the beliefs of the Kayah and Karen peoples, such amulets prevent the "departure of the soul" during illness. In some villages in Thailand, dried leaves are hung in living quarters on New Year's Day to "attract order and banish the unclean."

Thus, Albizia myriophylla occupies an important place in the ethnomedical and ritual systems of Southeast Asia, combining medicinal, magical and protective aspects of traditional culture.