​Red Light Therapy Panel 660-680 nm

Red Light Therapy Panel 660-680 nm

Product Name: Терапевтический излучатель, Red Light Therapy Panel, Therapeutischer Strahler, Emisor Terapéutico de Luz, Émetteur Thérapeutique de Lumière, باعث ضوء علاجي, เครื่องกำเนิดแสงบำบัด, Терапевтик нур таратгичи, Терапевтик нур чыгаргыч, Terapevtik işıq yayıcı, Излучатели табобати нури, Gydomasis šviesos spinduliuotuvas, Terapeitiskais gaismas starotājs, Терапевтичний випромінювач, מפיץ אור טיפולי

Main Indications for Use Red Light Therapy Panel: Degenerative joint diseases, osteoarthritis, chronic pain syndrome, myofascial pain syndrome, chronic dermatitis, acne vulgaris, trophic ulcers, diabetic angiopathy, chronic venous insufficiency, trigeminal neuralgia, peripheral neuropathy, inflammatory diseases of mucous membranes, periodontitis.

Indications for Use of Red Light Therapy Panel as Part of Therapeutic Complexes: Malignant skin neoplasms (melanoma, basal cell carcinoma, squamous cell skin cancer), malignant tumors of the head and neck mucous membranes, gastric adenocarcinoma, esophageal carcinoma, squamous cell carcinoma of the cervix, soft tissue sarcomas, lymphomas, purulent-inflammatory processes of soft tissues, chronic osteomyelitis, fungal infections of the skin and mucous membranes, viral infections of the upper respiratory tract.

Main Pharmacological Properties of Red Light Therapy Panel: Photobiomodulatory, anti-inflammatory, analgesic, trophostimulating, reparative, antimicrobial, immunomodulatory, photosensitizing (in combination with methylene blue), photodestructive (as part of photodynamic therapy).

Composition of the Red Light Therapy Panel Device: Light Emitting Diodes, Red LED 660—680 nm, Near Infrared LED 850 nm, ABS body, Power supply unit

Functions of Components in the Red Light Therapy Panel:

• Red LED 660—680 nm (Red Range LEDs): Activation of photosensitizers, improvement of microcirculation, stimulation of reparative processes of skin and mucous membranes.
• Near Infrared LED 850 nm (Near-Infrared Range LEDs): Deep penetration into tissues, improvement of metabolism and microcirculation, anti-inflammatory action.
• ABS Body: Ensures operational safety and device durability.
• Power Supply Unit: Stable supply of electrical energy, prevents voltage spikes.

Product Form of Red Light Therapy Panel: LED therapeutic panel, dimensions 31 × 31 × 3.5 cm, number of diodes 225 pcs (113 × red range 660—680 nm, 112 × near-infrared range 850 nm). Radiation power density from 36 to 100 mW/cm² depending on distance (15—45 cm).

Dosage of Red Light Therapy Panel

Standard Dosage for Red Light Therapy Panel: Recommended exposure is 10—20 minutes at a distance of 15—30 cm from the skin surface, with a power density of 40—80 mW/cm². Used for chronic pain syndrome, osteoarthritis, myofascial pain syndrome, chronic dermatitis, acne, periodontitis. The procedure is preferably performed once a day in the afternoon, the course consists of 10—15 procedures.

Intensive Dosage for Red Light Therapy Panel: Exposure 20—30 minutes at a distance of 15—20 cm, power density 80—100 mW/cm². Used for trophic ulcers, diabetic angiopathy, chronic venous insufficiency, trigeminal neuralgia, peripheral neuropathy, inflammatory diseases of mucous membranes. Procedures are performed daily or every other day, course of 15—20 procedures.

Maximum Dosage for Red Light Therapy Panel: Exposure 30—40 minutes at a distance of 15 cm, power density 100—120 mW/cm², total dose up to 60 J/cm² per area. Used as part of photodynamic therapy for malignant skin neoplasms (melanoma, basal cell carcinoma, squamous cell skin cancer), tumors of head and neck mucous membranes, gastric adenocarcinoma, squamous cell carcinoma of the cervix. Used only in conjunction with photosensitizers (e.g., methylene blue) and under medical supervision.

Pediatric Dosage for Red Light Therapy Panel: Used in children over 7 years weighing from 25 kg. Exposure does not exceed 5—10 minutes at a distance of 25—30 cm, power density ≤40 mW/cm². Can be used for chronic dermatitis, acne, stomatitis, inflammatory diseases of mucous membranes. Use no more than once every 2 days. Data on safety of use in children under 7 years are not scientifically registered.

Prophylactic Dosage for Red Light Therapy Panel: Exposure 10—15 minutes at a distance of 25—30 cm, power density 35—50 mW/cm². Recommended for patients with chronic fatigue, stress disorders, vascular disorders, chronic venous insufficiency, as well as to accelerate regeneration after intense physical exertion. Prophylactic use — 2—3 times a week in courses of 4—6 weeks.

Contraindications for Red Light Therapy Panel: Absolute contraindications: active malignant neoplasms without accompanying photodynamic therapy, photosensitization (porphyria, taking photosensitizing drugs), acute inflammatory skin diseases, severe heart failure, epilepsy. Relative contraindications: pregnancy, lactation period, childhood under 7 years. No scientific data on contraindication in these conditions have been registered.

Side Effects of Red Light Therapy Panel: Scientifically registered side effects from overdose: erythema, local skin burn, dryness and peeling, headache, transient increase in skin temperature.

Adjustment for Patient Body Weight: For patients weighing less than 60 kg, exposure time is reduced by 25%. For patients weighing over 100 kg, exposure may be increased to the upper limit of the standard dosage, provided power density is monitored.

Storage Conditions and Service Life for Red Light Therapy Panel: Store in a dry place at temperatures from +5 to +40 °C, relative humidity not exceeding 85%, in original packaging. Protect from direct solar radiation and high-power electromagnetic field sources. Service life is at least 5 years subject to operating rules. After opening the packaging and starting operation, there are no additional restrictions on the period of use.

Instructions for Use of Red Light Therapy Panel by Diseases

1. Musculoskeletal System

Osteoarthritis, arthritis, myofascial pain syndrome, chronic pain in joints and muscles

• Distance: 15—25 cm
• Exposure: 15—20 minutes
• Power Density: 50—80 mW/cm²
• Frequency: Once a day, course of 10—15 procedures
• Features: Preferably in the evening, after exertion, without photosensitizers.

2. Skin and Soft Tissues

Chronic dermatitis, acne, eczema, trophic ulcers, diabetic foot

• Distance: 20—30 cm
• Exposure: 15 minutes
• Power Density: 40—60 mW/cm²
• Frequency: Daily or every other day, course of 12—20 procedures
• Features: For open wounds, use an aseptic dressing; combination with a photosensitizer is possible (methylene blue 0.01—0.1% for antimicrobial action).

3. Oral Diseases

Gingivitis, periodontitis, stomatitis, candidiasis of the oral mucosa, postoperative wound surfaces

• Distance: 10—15 cm (through protective goggles, mouth slightly open)
• Exposure: 5—10 minutes per affected area
• Power Density: 50—80 mW/cm²
• Frequency: Daily, course of 7—10 procedures
• Features: Preferably after rinsing with an antiseptic or applying a photosensitizer (methylene blue 0.01—0.05%).

4. Vascular Pathologies

Chronic venous insufficiency, diabetic angiopathy, ischemic trophic skin disorders

• Distance: 20—25 cm
• Exposure: 20 minutes
• Power Density: 50—70 mW/cm²
• Frequency: Once a day, course of 15—20 procedures
• Features: Apply in a lying position, fix the limb, preferably combine with massage or compression therapy.

5. Neurology

Trigeminal neuralgia, peripheral neuropathies

• Distance: 15—20 cm
• Exposure: 10—15 minutes per area
• Power Density: 40—60 mW/cm²
• Frequency: Daily, course of 10—15 procedures
• Features: Use protective goggles, avoid skin overheating.

6. Oncology (PDT with Methylene Blue)

Malignant neoplasms of skin and mucous membranes (melanoma, basal cell carcinoma, squamous cell skin and mucosal cancer, gastrointestinal adenocarcinoma — superficial lesions)

• Preparation: Application of methylene blue 0.01—0.1% locally to the tumor or mucosa, drug exposure 15—20 minutes.
• Irradiation:
  • Distance: 10—20 cm
  • Time: 20—30 minutes
  • Power Density: 80—100 mW/cm²
  • Total Dose: 40—60 J/cm²
• Frequency: 2—3 times a week, the course is determined by the protocol and stage of the disease.
• Features: Used only under medical supervision, eye protection is mandatory; for deep tumors, interstitial PDT (optical fiber) is required.

7. Prevention

Chronic fatigue, stress disorders, microcirculation support

• Distance: 25—30 cm
• Exposure: 10—15 minutes
• Power Density: 30—40 mW/cm²
• Frequency: 2—3 times a week, course of 4—6 weeks
• Features: Preferably in the evening, without photosensitizers.

Important:

• All dosages are calculated for an adult patient with an average body weight of 60—80 kg.
• For children (over 7 years), exposure time is reduced by 2—3 times.
• For body weight <60 kg, exposure is reduced by 25%.

Toxicity and Biosafety — Therapeutic Emitter (Red Light Therapy Panel)

Based on analysis of materials and emission spectrum, the device belongs to the category of non-phototoxic when regulated exposure parameters are observed.

1. Housing and Construction Materials

• The main housing material is medical-grade ABS plastic. According to toxicological studies, the LD₅₀ for ABS polymer upon oral administration to rats is more than 15 g/kg body weight, indicating low acute toxicity. The material is chemically stable and does not release toxic substances during normal operation.

2. Light Emitting Diodes (LED 660—680 nm and 850 nm)

• Semiconductor LEDs are hermetically sealed and do not release toxic substances during operation. No toxin release occurs upon mechanical damage to the housing.
• Radiation in the 660—850 nm range lacks ionizing activity and does not cause mutagenic effects.
• Biosafety is confirmed by photobiomodulation studies: at doses up to 60 J/cm², no tissue or cellular DNA damage is observed.

3. Biosafety in Relation to Tissues

• At power densities up to 100 mW/cm² and exposure up to 20 minutes on a skin area, no necrosis or burns occur.
• If recommended exposure is exceeded, local redness, reversible erythema is possible.
• There is no data on carcinogenicity or systemic toxicity.

4. Cumulative Toxicity of the Device

• Housing and electronic materials: LD₅₀ > 10 g/kg body weight (rats, orally).
• Radiation 660—850 nm: Belongs to the Non-ionizing radiation category, safe at therapeutic doses, but requires eye protection.
• The cumulative toxicity of the device is assessed as extremely low, the main risks are associated not with chemical toxicity, but with phototrauma from exposure overdose.

Photobiological Synergy — Red Light Therapy Panel

The LED therapeutic emitter combines two spectral ranges — red light (660—680 nm) and near-infrared light (850 nm), which have different but complementary biological effects. Red light primarily affects superficial tissues, including the epidermis and upper dermal layers, activating mitochondrial enzymes and stimulating cellular metabolism. The near-infrared range can penetrate to a depth of several centimeters, affecting muscles, connective tissue, and the vascular bed. The combined use of these spectra creates potentiating synergy, where superficial activation of cellular respiration is complemented by deep stimulation of microcirculation and reparative processes.

A number of experimental and clinical studies have shown that the combination of 660 and 850 nm has an additive and potentiating character: the red spectrum enhances mitochondrial respiration and ATP synthesis, while near-infrared light complements this effect by increasing tissue oxygenation and vasodilation. This mechanism provides pronounced tissue-specific synergism, especially in conditions requiring simultaneous restoration of superficial and deep structures.

An additional level of synergy manifests when the emitter is combined with photosensitizers, primarily methylene blue, which has an absorption maximum in the 660 nm range. Under the action of red light, methylene blue molecules transition to an excited state and generate reactive oxygen species, which has cytotoxic and antimicrobial action. Simultaneous use of the near-infrared range modulates local metabolism and microcirculation, creating conditions for deeper penetration of reactive oxygen species into tissues and potentiating the photodynamic effect. Thus, the interaction of 660 nm and 850 nm in combination with photosensitizers forms a combined mechanism of action with an additive and modulating character.

Photobiological synergy as a whole can be characterized as systemic: superficial mechanisms enhance metabolism and cellular energy supply, while deep processes provide trophic support and microcirculation regulation. The mutual complementarity of these effects is confirmed by both in vitro cell culture models and in vivo studies in animals and humans. As a result, a multi-level potentiating effect is created, which goes beyond simple additivity and reflects the synergy of 'superficial and deep light' characteristic of phototherapy.

References: Hamblin MR. Photobiomodulation, photomedicine, and laser surgery. 2017; Chung H et al., Ann Biomed Eng. 2012; Karu TI, Photochem Photobiol Sci. 2008.

Photodynamics and Photobiomodulation — Red Light Therapy Panel

The therapeutic emitter in the 660—680 nm and 850 nm ranges affects biological tissues through mechanisms of photobiomodulation and photodynamics. Red light (660—680 nm) is actively absorbed by mitochondrial chromophores, primarily cytochrome c oxidase, leading to increased respiratory chain activity, increased ATP synthesis, and normalization of cellular metabolism. This action has a systemic effect through the activation of energy processes, as well as a tissue-specific effect manifested in accelerated cell proliferation, collagen synthesis, and epithelial regeneration.

The near-infrared spectrum (850 nm) has deeper penetrating ability. It exerts a modulating influence on muscular and connective tissue structures, improves microcirculation by stimulating endothelial nitric oxide production, and reduces the activity of pro-inflammatory mediators (TNF-α, IL-6). At the nervous system level, 850 nm light demonstrates neuromodulatory action, improving impulse conduction in peripheral nerves and promoting axon regeneration.

The combined use of red and near-infrared light in one device creates a multi-level pharmacodynamic analogue: superficial structures receive a stimulus for energy restoration and repair, while deep tissues undergo modulation of inflammatory and vascular processes. Such an effect is explained by the cumulative impact on enzyme cascades, cytokine pathways, and microcirculation regulation.

When using photosensitizers, such as methylene blue, the 660 nm radiation additionally initiates photodynamic processes: excited sensitizer molecules transfer energy to molecular oxygen with the formation of singlet oxygen and other reactive species, leading to a pronounced cytotoxic effect on pathological cells and microorganisms. Thus, the device combines the effects of photobiomodulation and photodynamics, making it a universal tool for a wide range of experimental and therapeutic tasks.

References: Hamblin MR, Bicknell B, Photomedicine and Laser Surgery. 2016; Huang YY et al., BBA Clinical. 2015; Karu TI. Mechanisms of low-power light therapy. 1999.

Pharmacokinetics — Red Light Therapy Panel

Absorption of radiation in the 660—680 nm range occurs primarily in the epidermis and upper dermal layers. The main acceptors of photons are mitochondrial chromophores, including cytochrome c oxidase, as well as flavoproteins and porphyrins. Red light energy is absorbed at a depth of up to several millimeters, where photobiomodulation processes are initiated.

Infrared radiation with a wavelength of 850 nm has greater penetrating ability, reaching underlying muscle layers and connective tissue. It is partially scattered in the intercellular matrix and partially absorbed by intracellular structures, providing tissue-specific distribution of photon energy.

The metabolism of light exposure is not associated with chemical transformation of a substance but is realized through biophysical processes: excitation of mitochondrial electron transport chains, temporary increase in the production of reactive oxygen species in subphysiological concentrations, modulation of cellular signaling cascades. Subsequently, the energy is redistributed in the form of increased ATP synthesis and activation of enzyme systems.

Elimination of excess energy occurs through heat dissipation processes, as well as through the restoration of tissue metabolism to the basal level. No accumulation of photon energy in biological structures is observed; all effects are transient.

References: Karu TI. Photobiology of low-power laser effects. Health Phys. 1989; Hamblin MR. Mechanisms of photobiomodulation. Photochem Photobiol Sci. 2018.

Mechanisms of Action and Scientific Rationale: Red Light Therapy Panel

Liver and Gastrointestinal Tract. Photonic exposure in the 660—850 nm range modulates the activity of mitochondria in hepatocytes and gastrointestinal mucosal cells. The main mechanism is the activation of cytochrome c oxidase, increased ATP synthesis, and reduced oxidative stress. Light stimulates antioxidant enzymes (superoxide dismutase, catalase), exerts membrane-stabilizing and lipotropic effects. The nature of interaction is modulating and tissue-specific, the level of action is cellular.
Reference: Hamblin MR, Demidova TN. Mechanisms of low level light therapy. Proc SPIE. 2006.

Immune System. Red and near-infrared light regulate the functional activity of macrophages and neutrophils, modulate cytokine production (IL-1β, IL-6, TNF-α), and promote the activation of anti-inflammatory cascades. Impact on NF-κB and JAK/STAT pathways leads to a reduction in the synthesis of pro-inflammatory mediators and enhancement of the anti-inflammatory response. The interaction is additive with subsequent potentiation of the immunomodulatory effect.
Reference: Chen AC-H et al. Low-level laser therapy activates NF-κB via generation of reactive oxygen species in mouse embryonic fibroblasts. PLoS One. 2011.

Nervous System. 850 nm radiation demonstrates neuroprotective and neuromodulatory action. It improves axonal conduction, stimulates regeneration of damaged neurons, activates MAPK and PI3K/AKT signaling pathways. Red light (660 nm) additionally exerts a regulatory influence on neurotransmitter release and improves synaptic plasticity. The effect is potentiating when the ranges are combined.
Reference: Hamblin MR. Shining light on the head: photobiomodulation for brain disorders. BBA Clinical. 2016.

Endocrine and Metabolic Regulation. Photonic exposure in the red and infrared range enhances local nitric oxide production, leading to vasodilation and improved microcirculation. At the cellular level, an influence on AMPK and mTOR signaling pathways involved in the regulation of energy metabolism and lipid metabolism is noted. The effect is modulating and manifests in the systemic normalization of tissue energy homeostasis.
Reference: Passarella S, Karu T. Absorption of monochromatic and narrow band radiation in the visible and near IR by cytochrome c oxidase. Photochem Photobiol B. 2014.