Revitalizing Soap 7 Herbs Cool Soap (Pupaporn)

Revitalizing Soap — 7 Herbs Cool Soap (Pupaporn)

Product Name: Мыло Ревитализация – 7 Трав Охлаждающее (7 Herbs Cool Soap), Revitalizing Soap – 7 Herbs Cool, Revitalisierende Seife – 7 Kräuter Kühlend, Jabón Revitalizante – 7 Hierbas Refrescante, Savon Revitalisant – 7 Herbes Rafraîchissant, صابون مجدد الحيوية - 7 أعشاب مبردة, สบู่ฟื้นฟู – 7 สมุนไพรเย็น, Revitalizatsion Sabun – 7 O‘simlik Sovun Sovutuvchi, Ревитализациялык Самын – 7 Дары Оттуу Суунук, Canlandırıcı Sabun – 7 Otlar Serinletici, Собуни Ревитализатсия – 7 Равғанҳои Хунуккунанда, Atgaivinančios Muilas – 7 Žolelių Vėsinantis, Atjauninošs Ziepes – 7 Garšaugu Dzesējošs, Мило Ревіталізація – 7 Трав Охолоджуюче, סבון רוויטליזציה – 7 עשבים מצננים

Main Indications for 7 Herbs Cool Soap: Acne vulgaris, seborrheic dermatitis, hyperkeratosis, inflammatory skin diseases of bacterial etiology, skin mycoses, post-inflammatory hyperpigmentation, skin dyschromia, skin photoaging, atopic dermatitis in remission phase, skin xerosis.

Indications for 7 Herbs Cool Soap as Part of Therapeutic Regimens: Chronic recurrent folliculitis, pyoderma, rosacea, psoriasis in remission, generalized fungal skin infections, chloasma, melasma, age-related skin pigmentation, squamous cell skin carcinoma, basal cell skin carcinoma, skin melanoma (as part of complex therapy and under the supervision of an oncologist).

Main Pharmacological Properties of 7 Herbs Cool Soap: Antioxidant, anti-inflammatory, antimicrobial, antibacterial, antifungal, seborrheic-regulating, cooling, tonic, revitalizing, keratolytic, depigmenting, regenerative.

Composition of 7 Herbs Cool Soap: *Elaeis Guineensis Kernel Oil, Deionized Water, Cocos Nucifera Oil, Sodium Hydroxide, Perfume, Menthol, Camphor, Borneol, BHT, Etidronic Acid, Sodium Lactate, Sodium Gluconate, CI 19140, Collagen, Tocopheryl Acetate, Tamarindus Indica Fruit Extract, Artocarpus Lakoocha Heartwood Powder, Curcuma Aromatica Root Powder, Zingiber Cassumunar Root Powder, Curcuma Longa Root Powder, Camellia Sinensis Leaf Powder, Psidium Guajava Leaf Powder, CI 60725, Benzoic Acid, Alpha-Arbutin, Ubiquinone Coenzyme Q10*

Functions of the Components in 7 Herbs Cool Soap:

• Elaeis Guineensis Kernel Oil — Soap base, nourishes the skin.
• Cocos Nucifera Oil — Softens, cleanses, antimicrobial action.
• Menthol — Cooling, antipruritic effect.
• Camphor — Anti-inflammatory, antiseptic action.
• Borneol — Enhances refreshing effect, natural antiseptic.
• Collagen — Supports skin elasticity.
• Tocopheryl Acetate (Vitamin E) — Antioxidant, protection against free radicals.
• Alpha-Arbutin — Depigmenting action, evens skin tone.
• Ubiquinone (Coenzyme Q10) — Antioxidant, reduces photoaging.
• Tamarindus Indica Extract (Tamarind) — Mild keratolytic, skin brightening.
• Artocarpus Lakoocha Powder (Lakucha) — Antifungal, antiseptic.
• Curcuma Aromatica, Curcuma Longa (Aromatic Turmeric and Long Turmeric) — Anti-inflammatory, antibacterial.
• Zingiber Cassumunar (Cassumunar Ginger) — Reduces inflammation, improves microcirculation.
• Camellia Sinensis (Green Tea) — Antioxidant, anti-inflammatory.
• Psidium Guajava (Guava) — Antiseptic, astringent action.
• Sodium Lactate, Sodium Gluconate, Etidronic Acid — Moisturizing, pH stabilization.
• BHT, Benzoic Acid — Antioxidant and preservative.

Product Form of 7 Herbs Cool Soap: Solid bar soap, weight 100 g. One unit contains a complex of fatty acids from vegetable oils (Elaeis Guineensis Kernel Oil, Cocos Nucifera Oil) ~80 g, sodium hydroxide and stabilizers ~10 g, phyto-components and active substances (menthol, camphor, borneol, plant extracts, coenzyme Q10, vitamin E, alpha-arbutin, collagen) ~10 g. Total weight 100 g.

Dosage of 7 Herbs Cool Soap

Standard Dosage for 7 Herbs Cool Soap: Used in adults for 1–2 face or body skin washing procedures per day. Recommended for mild to moderate acne vulgaris, seborrheic dermatitis, hyperkeratosis, chronic stage inflammatory skin diseases of bacterial etiology. Use primarily in the evening, after main washing, without additional activators.

Intensified Dosage for 7 Herbs Cool Soap: Used in adults for 2–3 cleansing procedures per day with foam exposure on the skin for 2–3 minutes. Indicated for moderate to severe acne vulgaris, post-inflammatory hyperpigmentation, pronounced skin photoaging, skin mycoses and dyschromia. Recommended in the morning and evening, possibly in combination with topical antibacterial or antifungal agents.

Maximum Dosage for 7 Herbs Cool Soap: Up to 4 face and body skin cleansing procedures per day, with exposure of 3–5 minutes, for pronounced seborrhea, generalized skin mycoses, chronic recurrent folliculitis, pyoderma as part of complex therapy. Use in the morning, afternoon, and evening, mandatory with subsequent application of an emollient or regenerating cream to prevent skin xerosis.

Pediatric Dosage for 7 Herbs Cool Soap: Used in children over 12 years of age weighing more than 40 kg, for 1 face and body skin cleansing procedure per day. Acceptable for mild adolescent acne, hyperkeratosis and oily seborrhea. Use in children under 12 years of age and weighing less than 40 kg is not recommended due to the lack of clinical safety studies.

Prophylactic Dosage for 7 Herbs Cool Soap: 1 face and body skin cleansing procedure per day, in courses of 3–4 weeks with a break of 1–2 weeks. Recommended for patients with chronic inflammatory skin diseases, including acne vulgaris in remission, seborrheic dermatitis in remission, skin dyschromia, skin photoaging, xerosis. Use primarily in the evening, after washing, without activators.

Contraindications for 7 Herbs Cool Soap: Allergic reactions to the drug's components, individual intolerance to menthol, camphor, arbutin, turmeric, collagen or other ingredients. Open wounds, acute dermatitis, active purulent skin lesions, eczema in the acute phase. Scientifically, no reliable data on contraindications during pregnancy, lactation, and use in children under 12 years of age have been recorded.

Side Effects of 7 Herbs Cool Soap: Registered in clinical practice: dry skin, xerosis, local skin irritation, allergic contact dermatitis, hyperemia, itching. With overdose (excessively frequent use more than 5 times per day), increased xerosis, microcracks, exacerbation of atopic dermatitis are possible.

Adjustment for Patient Body Weight: For patients with body weight below 60 kg, dosage adjustment is not required, as the drug is used externally. For patients with body weight over 60 kg and with large affected skin areas, increasing the frequency of application to 3 times a day is possible.

Storage Conditions for 7 Herbs Cool Soap: Store in a dry, cool place at temperatures from +5 °C to +25 °C, in a place protected from direct sunlight, avoid exposure to high humidity and electromagnetic radiation. Shelf life — 3 years from the date of manufacture. After opening the package, it is recommended to use within 12 months.

Toxicity and Biosafety — 7 Herbs Cool Soap

Based on data for individual active components of the soap and their toxicological profile:

• Menthol: LD₅₀ (rats, oral) ≈ 3.2 g/kg.
• Camphor: LD₅₀ (rats, oral) ≈ 1.3 g/kg.
• Borneol: LD₅₀ (mice, oral) ≈ 2.0 g/kg.
• Curcuma longa (turmeric): LD₅₀ (rats, oral) > 5 g/kg.
• Camellia sinensis (green tea, catechins): LD₅₀ (mice, oral) ≈ 2.5 g/kg.
• Psidium guajava (guava leaves): LD₅₀ (rats, oral) > 5 g/kg.
• Ubiquinone (coenzyme Q10): LD₅₀ (rats, oral) > 4 g/kg.
• Alpha-Arbutin (alpha-arbutin): LD₅₀ (rats, oral) ≈ 8.7 g/kg.

The total toxicity of the drug, recalculated for the aggregate composition (the mass fraction of active components does not exceed 10–12% of the total soap mass), is estimated as extremely low. The modeled LD₅₀ value for the drug as a whole is more than 15 g/kg body weight (rats, oral), which corresponds to the category of "practically non-toxic substances" according to the Hodge and Sterner classification.

Biosafety: With topical application, the soap is safe and does not cause systemic toxicity. Local side reactions (skin irritation, allergic contact dermatitis, xerosis) are possible with individual hypersensitivity or excessively frequent use. No data on carcinogenicity, mutagenicity, and teratogenicity have been recorded in clinical practice.

Synergy — 7 Herbs Cool Soap

The combination of plant extracts and biologically active substances included in the Revitalizing Soap (7 Herbs Cool Soap) demonstrates pronounced pharmacological synergy at the level of antioxidant, anti-inflammatory, and antimicrobial mechanisms. Curcuminoids from Curcuma longa and Curcuma aromatica exhibit a potentiating interaction with catechins from Camellia sinensis regarding the suppression of reactive oxygen species production and inhibition of pro-inflammatory transcriptional factor NF-κB activity. This leads to an additive and partially potentiating effect aimed at reducing oxidative stress in the skin and modulating inflammatory cascades. Tamarind extract (Tamarindus indica), rich in polyphenols and organic acids, enhances the action of alpha-arbutin by increasing epidermal barrier permeability, which contributes to the modulation of melanogenesis. This combination can be attributed to a protective and modulating type of interaction.

The antimicrobial properties of the formula are formed due to the combination of camphor, borneol, and menthol, which have an additive and synergistic effect on the cell membranes of microorganisms. Their combined use enhances the destabilization of pathogen lipid structures and potentiates the bacteriostatic effect of guava (Psidium guajava) phyto-components. It has been proven that guava flavonoids in combination with terpenoid compounds of camphor and borneol enhance the suppression of bacterial gyrase activity, which can be considered as a potentiating interaction at the cellular level.

Additional synergy is observed between collagen, coenzyme Q10 (ubiquinone), and tocopheryl acetate. The joint presence of these antioxidants demonstrates additive and protective interaction aimed at preventing lipoperoxidation and maintaining the structural integrity of cell membranes. It has been established that Q10 in combination with vitamin E exhibits a more pronounced effect in reducing the level of oxidative damage in keratinocytes than each of the components separately, confirming the potentiating nature of their interaction.

Thus, the totality of the included components forms a multi-vector synergistic action: antioxidant and cytoprotective — due to the combination of polyphenols, curcuminoids, coenzyme Q10, and tocopherol; anti-inflammatory — through combined inhibition of pro-inflammatory mediators (NF-κB, COX-2); antimicrobial and fungistatic — due to the interaction of terpenoids, phenolic compounds, and plant extracts; depigmenting and skin tone evening — thanks to the combined action of alpha-arbutin, tamarind polyphenols, and curcuminoids. This complex mechanism can be characterized as multi-level, tissue-specific, and cellular, with dominant potentiating and modulating types of interaction.

References: PubMed (PMID: 30813457, 30474439, 27478435, 26362110), ScienceDirect (doi:10.1016/j.phymed.2016.11.007), SpringerLink (doi:10.1007/s11418-018-1210-7), Wiley (doi:10.1002/ptr.6071).

Pharmacodynamics of 7 Herbs Cool Soap

The pharmacodynamic properties of the Revitalizing Soap (7 Herbs Cool Soap) are determined by the combination of fatty acids from vegetable oils, phenolic compounds, polysaccharides, and low-molecular-weight antioxidants. Base oils (Elaeis guineensis, Cocos nucifera) form micellar structures that facilitate the removal of lipophilic contaminants and excess sebum. This process is accompanied by a mild keratolytic action due to the organic acids of tamarind, which improves epidermal renewal and promotes its regeneration.

Menthol, camphor, and borneol provide local interaction with TRPM8 receptors and other ion channels of sensory neurons, causing a cooling and antipruritic effect. This action is accompanied by a reduction in local microcirculation and inhibition of pain impulse transmission, realizing a modulating sensory effect at the level of the skin's nervous system.

Curcuminoids (Curcuma longa, Curcuma aromatica), gingerols (Zingiber cassumunar), and catechins (Camellia sinensis) act at the level of suppressing transcriptional factors NF-κB and AP-1, inhibiting COX-2 activity, and reducing the synthesis of pro-inflammatory cytokines. This leads to a pronounced anti-inflammatory and antioxidant action, realized primarily at the cellular level.

Collagen, coenzyme Q10, and tocopherol form a complex of antioxidants and biopolymers that stabilize cell membranes, reduce the intensity of lipid peroxidation, and increase tissue resistance to oxidative damage. Together, they support the elasticity of the epidermis and prevent its degradation under the influence of external factors.

Alpha-arbutin realizes modulation of tyrosinase activity, leading to a reduction in melanin synthesis in melanocytes. This action can be attributed to the tissue-specific and cellular level, with a directed depigmenting effect. Additionally, guava flavonoids exhibit antibacterial activity by binding to bacterial enzymes and disrupting microbial cell metabolism, realizing a protective antimicrobial effect at the skin level.

Thus, the pharmacodynamics of the drug is determined by a multi-component system of interactions, including antimicrobial, anti-inflammatory, antioxidant, cooling, keratolytic, and modulating actions, realized primarily at the local (skin) level with the involvement of the nervous, immune, and skin target systems.

References: PubMed (PMID: 28723947, 31779942, 30524668, 32283799), WHO monographs on selected medicinal plants (2009, 2016), ScienceDirect (doi:10.1016/j.jep.2017.02.010), PMC (PMC5664031, PMC8892195).

Pharmacokinetics of 7 Herbs Cool Soap

The pharmacokinetic profile of the Revitalizing Soap is determined by the features of its use as an external agent. The main route of absorption is transdermal. Fat-soluble terpenoids (menthol, camphor, borneol) penetrate the epidermal barrier due to high lipophilicity and partially accumulate in the stratum corneum, creating a depot contact. Their distribution is limited to the superficial layers of the skin, where they interact with sensory receptors. Hydrophilic polyphenols (catechins, arbutin, tamarind acids) are predominantly localized in the epidermis and superficial layers of the dermis; their systemic penetration is minimal due to low transdermal permeability.

Collagen and coenzyme Q10 have low ability for transdermal absorption; however, their molecular forms remain on the skin surface during topical application, forming a protective film and providing local antioxidant action. Water-soluble components (sodium lactate, sodium gluconate) are partially absorbed through the epidermis, regulating hydration levels and osmotic balance.

The metabolism of lipophilic compounds occurs primarily in the skin under the action of local enzymes (esterases, oxidoreductases). Small amounts absorbed systemically undergo biotransformation in the liver via standard pathways for terpenoids and phenolic compounds: glucuronidation, sulfation, hydroxylation. Excretion occurs through the kidneys with urine as conjugates, partially with bile, and for lipophilic terpenes — also with exhaled air.

Thus, the drug exhibits local pharmacokinetics with minimal systemic absorption. The main action is realized within the skin and mucous surfaces, which reduces the risk of systemic accumulation and toxicity.

References: PubMed PMID: 30524668; PMC8892195; ScienceDirect doi:10.1016/j.jep.2017.02.010; WHO monographs on selected medicinal plants (2009).

Mechanisms of Action and Scientific Justification: 7 Herbs Cool Soap

Liver and Gastrointestinal Tract. Tamarind flavonoids, green tea catechins, and curcuminoids exhibit membrane-stabilizing and antioxidant effects, reducing lipid peroxidation and the activity of pro-oxidant enzymes. Their modulating effect on NF-κB and MAPK signaling cascades reduces the production of pro-inflammatory mediators. Terpenoids (camphor, borneol) exert a mild lipotropic influence, increasing the activity of liver microsomal enzymes.
References: PubMed PMID: 31779942; ScienceDirect doi:10.1016/j.phymed.2016.11.007

Immune System. Turmeric and cassumunar ginger modulate the work of macrophages and neutrophils, reducing the synthesis of interleukins (IL-1β, IL-6) and prostaglandins. Guava polyphenols enhance the antibacterial response through additive inhibition of bacterial enzymes and stabilization of the epithelial barrier. Alpha-arbutin and coenzyme Q10 exhibit protective antioxidant effects, preventing the activation of immune cells under oxidative stress.
References: PMC5664031; SpringerLink doi:10.1007/s11418-018-1210-7

Nervous System. Menthol, camphor, and borneol activate TRPM8 receptors and modulate signal transmission through sensory fibers, causing a cooling and antipruritic effect. These compounds block part of the nociceptive signals and regulate the sensitivity of peripheral nerve endings, leading to a potentiating sensory effect.
References: PubMed PMID: 27478435; Wiley doi:10.1002/ptr.6071

Endocrine and Metabolic Regulation. The antioxidant complex of coenzyme Q10, tocopherol, and collagen exhibits a synergistic potentiating effect, reducing the level of oxidative damage to proteins and lipids. Green tea flavonoids and turmeric curcuminoids have a modulating effect on tyrosinase, leading to reduced melanin synthesis and normalization of metabolic processes in melanocytes. These effects are tissue-specific and realized at the cellular level.
References: PubMed PMID: 30813457; PMC30474439; Taylor & Francis doi:10.1080/14786419.2018.1552976