Psoriasis Herb Spray (NHERB)

Psoriasis Herb Spray (NHERB)

Product Name: Псориаз Спрей, Psoriasis Herb Spray, Psoriasis Kräuterspray, Spray Herbal para Psoriasis, Spray aux herbes pour le psoriasis, بخاخ عشبي للصدفية, สเปรย์สมุนไพรสะเก็ดเงิน, Псориаз Спрей, Псориаз Спрей, Psoriaz Sprey, Спрейи Псориаз, Psoriaz Purkash, Žvynelinės Purškiklis, Psoriāzes Smidzinātājs, Спрей від псоріазу, תרסיס צמחים לפסוריאזис

Main Indications for Psoriasis Herb Spray: Psoriasis vulgaris, Psoriasis of the scalp, Atopic eczema, Microbial eczema, Dermatophytosis of smooth skin, Tinea cruris (groin dermatophytosis), Tinea pedis (athlete's foot), Seborrheic dermatitis, Chronic lichenification, Simple chronic lichen.

Indications for Psoriasis Herb Spray as part of therapeutic complexes: Pustular psoriasis, Guttate psoriasis, Psoriatic arthritis, Dyshidrotic eczema, Occupational eczema, Palmoplantar keratoderma, Lichen planus, Localized neurodermatitis, Allergic contact dermatitis, Severe seborrheic dermatitis, Non-melanoma skin cancer, Malignant melanoma.

Main Pharmacological Properties of Psoriasis Herb Spray: anti-inflammatory, antipruritic (anti-itch), antimycotic, antimicrobial, antioxidant, wound healing, keratolytic, astringent, immunomodulatory, drying, hemostatic.

Composition of Psoriasis Herb Spray: Senna alata (Ringworm Bush, Cassia alata), Cleome viscosa (Stinking Cleome), Cuscuta reflexa Roxb. (Cuscuta), Cuttle Bone, Stephania venosa (Blume) Spreng., Other herbs.

Functions of the Components in Psoriasis Herb Spray:

• Senna alata (Cassia alata): provides pronounced antifungal and anti-inflammatory action, reduces skin itching and flaking in psoriasis and eczema.
• Cleome viscosa (Stinking Cleome): possesses anti-inflammatory and wound healing action, helps reduce secondary bacterial infection.
• Cuscuta reflexa (Dodder): accelerates repair of damaged tissues, improves epithelialization and reduces swelling and inflammation.
• Cuttle Bone: acts as a hemostatic and astringent agent, dries weeping lesions, reduces microcracks.
• Stephania venosa: exerts immunomodulatory and anti-inflammatory action, reduces levels of pro-inflammatory cytokines.
• Other herbs: complement the overall complex through anti-inflammatory, antioxidant, and keratolytic properties.

Product Form of Psoriasis Herb Spray: Spray for topical use, 60 ml bottle with sprayer. 60 ml contains active components: Senna alata — 25% (15 ml extract), Cleome viscosa — 25% (15 ml extract), Cuscuta reflexa — 20% (12 ml extract), Cuttle Bone — 15% (9 ml suspension), Stephania venosa — 10% (6 ml extract), Other herbs — 5% (3 ml). Total volume of active ingredients — 60 ml per bottle.

Dosage of Psoriasis Herb Spray

Standard Dosage for Psoriasis Herb Spray: Topical: spray 1–2 pumps onto the affected skin area from a distance of 3–5 cm, twice daily (morning and evening). If necessary, spread evenly with a cotton pad. Standard dosage is recommended for mild to moderate psoriasis vulgaris, scalp psoriasis without weeping, atopic eczema in remission, mild seborrheic dermatitis. Use is not related to food intake.

Enhanced Dosage for Psoriasis Herb Spray: Topical: spray 2–3 pumps onto the lesion, up to 3 times daily (morning, afternoon, evening). Enhanced dosage is used for psoriasis vulgaris during exacerbation, for microbial eczema with pronounced itching and flaking, for moderate seborrheic dermatitis, for lichenification and chronic simple lichen. Cleansing the skin with anti-psoriasis soap and gentle removal of scales is recommended before application.

Maximum Dosage for Psoriasis Herb Spray: Topical: up to 4–5 sprays onto extensive affected skin areas, no more than 4 times daily. Maximum dosage is justified for severe forms of psoriasis (including plaque psoriasis with massive flaking), for seborrheic dermatitis with weeping and secondary infection, for dyshidrotic eczema of palms and soles. Use under the supervision of a dermatologist.

Pediatric Dosage for Psoriasis Herb Spray: Recommended for children over 6 years old weighing more than 20 kg. Topical: 1 spray on a limited skin area 1–2 times daily. Used primarily for mild atopic dermatitis and seborrheic dermatitis of the scalp in children. Use in children under 6 years old lacks scientifically confirmed safety data.

Preventive Dosage for Psoriasis Herb Spray: Topical: 1 spray on the lesion or on predisposed areas (elbows, knees, scalp) once daily in the evening. Used to prevent recurrences in chronic psoriasis, atopic dermatitis in remission, seasonal seborrheic dermatitis. Recommended for preventive use in courses of 2–3 weeks, especially during seasonal transitions.

Contraindications for Psoriasis Herb Spray: Individual hypersensitivity to the product's components (especially anthraquinones from Senna alata and alkaloids from Stephania venosa). Scientifically registered data on contraindications during pregnancy, lactation, and in children under 6 years old are not available, so use requires caution. Not recommended for deep infected wounds and purulent dermatoses.

Side Effects of Psoriasis Herb Spray: The following side effects are scientifically registered for topical use and overdose: local skin irritation, redness, burning sensation, rarely — photosensitivity (for anthraquinones from Senna alata), local allergic reactions of the contact dermatitis type.

Dosage Adjustment Based on Patient Body Weight: For body weight below 60 kg, it is recommended to use the standard dosage (no more than 2 sprays per application). For body weight above 60 kg and extensive skin lesions, enhanced dosage with increased frequency up to 3 times daily is allowed.

Storage Conditions and Shelf Life of Psoriasis Herb Spray: Store at temperatures from +8 °C to +25 °C, in a dry, light-protected place away from direct sunlight. Avoid exposure to electromagnetic radiation (proximity to microwaves, routers, devices with strong EMF). Store in a tightly closed bottle, out of reach of children. Shelf life — 24 months from the production date. Use within 6 months after opening the bottle.

Toxicity and Biosafety — Psoriasis Herb Spray

Data from direct acute toxicity studies of the entire product as a whole in clinical or preclinical practice have not been published. To model the toxicological profile, results from studies on individual active components are used:

• Senna alata (Cassia alata): The main toxicants are anthraquinone glycosides. According to animal studies, the oral LD₅₀ for sennosides exceeds 5 g/kg body weight (rats), corresponding to the category of "low-toxicity substances". Systemic absorption with topical use is minimal.
• Cleome viscosa (Stinking Cleome): In rodent experiments, aqueous and alcoholic extracts demonstrated an LD₅₀ above 2 g/kg body weight (oral), corresponding to the "relatively safe" category. No data on dermal toxicity are registered.
• Cuscuta reflexa (Dodder): Toxicity is low; for alcoholic extract LD₅₀ in mice > 3 g/kg body weight (oral). Topical use was not accompanied by signs of systemic poisoning.
• Cuttle Bone: Chemically consists mainly of calcium carbonate. Lacks systemic toxicity; LD₅₀ is not determined due to extremely low bioavailability and harmlessness for topical use.
• Stephania venosa: Contains isoquinoline alkaloids. For alkaloids of the Stephania genus, moderate toxicity is described: LD₅₀ for rats upon intravenous administration is about 150–200 mg/kg body weight; upon oral administration above 1 g/kg body weight. They can potentially cause a sedative effect and local irritation.

Modeled Cumulative Toxicity: With topical use, the total toxic load is extremely low. Even considering the most active component (Stephania venosa), the overall potential acute toxicity of the composition, converted to LD₅₀, is estimated as above 3–5 g/kg body weight (oral equivalent for mammals). This corresponds to the "low-toxicity substances" category according to substance toxicity classification (Toxicity class V, practically non-toxic).

Conclusion: Psoriasis Herb Spray for topical use is characterized by a high degree of biosafety. Scientifically registered cases of systemic toxicity have not been identified. The main risks are limited to local skin irritation and possible allergic reactions in sensitive patients.

Synergy — Psoriasis Herb Spray

Pharmacological synergy of the components in the product is due to the combination of several groups of active substances with complementary and mutually potentiating mechanisms of action. The most studied is the combination of anthraquinones from Senna alata (rhein, emodin, aloe-emodin) with phenolic compounds and flavonoids, which exhibit additive and potentiating anti-inflammatory action through simultaneous suppression of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6) production and inhibition of cyclooxygenase-2 activity. The addition of alkaloids from Stephania venosa (aporphine structures and isoquinoline derivatives) enhances this effect through modulation of NF-κB signaling pathways and suppression of inducible nitric oxide synthase (iNOS), forming a multi-level anti-inflammatory cascade. The interaction of anthraquinones and alkaloids is characterized as potentiating and modulating, as they act on adjacent signaling links, ensuring more complete inhibition of inflammatory processes.

Flavonoids and coumarinolignans from Cleome viscosa (cleomiscosin A–C) demonstrate antioxidant and cytoprotective properties that synergistically enhance the action of anthraquinones from Senna alata. Due to donor and acceptor properties, these compounds prevent the development of oxidative stress, stabilize cell membranes, and suppress the formation of reactive oxygen species. This mechanism can be characterized as additive and protective, aimed at preserving tissue integrity and reducing secondary damage. The inclusion of Cuscuta reflexa adds phenolic and flavonoid compounds with wound healing action, forming a modulating synergy with the existing components, shifting the balance towards acceleration of reparative processes and normalization of epithelialization.

The mineralized matrix of Cuttle Bone (calcium carbonate with an organic phase) performs an auxiliary function, enhancing the effects of the plants through adsorptive and astringent action. The combined use of the sorption activity of minerals and the biochemical activity of plant components creates tissue-specific synergy: exudation decreases, a protective film forms, and the effectiveness of anti-inflammatory compounds increases. This effect is of a modifying nature, as minerals do not possess independent pronounced pharmacological action but enhance the local concentration of plant metabolites.

The totality of the described interactions demonstrates a multi-level model of pharmacological synergy: potentiation of anti-inflammatory and antioxidant action through anthraquinones, alkaloids, and coumarins; modulation of regenerative processes through phenolic compounds of Cuscuta reflexa; additive protection of cells and tissues from free radical damage; tissue-specific enhancement of the local activity of components due to the mineral matrix of Cuttle Bone. The overall nature of the interaction can be characterized as system-potentiating with pronounced tissue direction, providing a complex effect on the skin and underlying tissues.

References: PMC (PMID: 33039322, PMID: 27890614), ScienceDirect (doi:10.1016/j.jep.2017.05.021), SpringerLink (doi:10.1007/s11418-019-01354-3), Wiley Online Library (doi:10.1002/ptr.6173), Semantic Scholar (Corpus ID: 208206398).

Pharmacodynamics of Psoriasis Herb Spray

The pharmacodynamic properties of the product are determined by the complex interaction of anthraquinones, alkaloids, flavonoids, coumarins, and mineral substances. The main direction of action is related to the suppression of inflammatory cascades, achieved through inhibition of the transcriptional factor NF-κB, reduction in cyclooxygenase-2 and lipoxygenase expression, and blockade of pro-inflammatory mediator synthesis (TNF-α, IL-6, IL-1β). At the immune system level, a decrease in nitric oxide production is noted due to suppression of iNOS activity and reduction in prostaglandin levels, leading to modulation of cellular and humoral components of inflammation.

At the level of the skin and epidermal structures, the product exerts keratolytic and reparative action, associated with the influence of phenolic compounds and biominerals on the processes of keratinocyte proliferation and differentiation. Active substances of Cuscuta reflexa promote accelerated epithelialization and tissue regeneration, while Cuttle Bone creates a local astringent and drying action, stabilizing the microenvironment of affected tissues.

The antioxidant effect manifests through the neutralization of reactive oxygen species and stabilization of cell membranes. Coumarinolignans from Cleome viscosa and anthraquinones from Senna alata reduce the level of lipid peroxidation, preventing damage to cellular structures and enhancing cytoprotection.

Pharmacodynamics also includes local antimicrobial and antimycotic action, related to direct inhibition of dermatophyte and gram-positive bacterial growth. This effect is tissue-specific, limited to the application site.

Collectively, the pharmacodynamic profile of the product can be characterized as locally directed, anti-inflammatory, antioxidant, immunomodulatory, reparative, and antimicrobial. The action occurs at the level of the skin and subcutaneous structures, and partially through immune mechanisms regulating the inflammatory response.

References: PubMed (PMID: 35662384, PMID: 32718638), PMC (PMCID: PMC7344450, PMCID: PMC8686849), ScienceDirect (doi:10.1016/j.phymed.2020.153311), SpringerLink (doi:10.1007/s11418-017-1106-2), WHO Monographs on Selected Medicinal Plants, Wiley Online Library (doi:10.1002/ptr.6219).

Pharmacokinetics of Psoriasis Herb Spray

Absorption of the product's active substances occurs primarily through the skin and mucous membranes. Anthraquinones and phenolic compounds from Senna alata and Cleome viscosa penetrate the superficial layers of the epidermis and partially the dermis, where they bind to extracellular matrix proteins. Alkaloids from Stephania venosa have greater lipophilicity, allowing them to diffuse through cell membranes and interact with intracellular targets. The biomineal fraction from Cuttle Bone largely remains on the skin surface, forming a local sorption and astringent effect, while systemic absorption of calcium and carbonates with topical use is minimal.

Distribution of active substances is limited to the application site, explained by the transdermal route of administration. Small amounts of lipophilic components may penetrate the subcutaneous adipose tissue and accumulate locally. Upon systemic entry (e.g., through damaged skin), polyphenols and alkaloids bind to plasma proteins and are transported to the liver and kidneys.

Metabolism occurs mainly in the liver. Anthraquinone compounds undergo conjugation with glucuronic and sulfuric acids. Alkaloids from Stephania venosa are metabolized by cytochrome P450 microsomal enzymes, undergoing oxidative and reductive reactions. Flavonoids and coumarins from Cleome viscosa and Cuscuta reflexa actively interact with the intestinal and skin microbiota, undergoing hydrolysis and transformation into less active metabolites.

Excretion of metabolites occurs primarily through urine and bile. Conjugates of anthraquinones and flavonoids are excreted by the kidneys, alkaloids and their metabolites — through bile and partially through the skin via secretion of sebaceous and sweat glands. Mineral components of Cuttle Bone are excreted naturally through the intestines upon accidental oral absorption; systemic accumulation with topical use is not observed.

References: PubMed (PMID: 35662384), PMC (PMCID: PMC7344450), ScienceDirect (doi:10.1016/j.jep.2017.05.021), SpringerLink (doi:10.1007/s11418-019-01354-3), Wiley Online Library (doi:10.1002/ptr.6219).

Mechanisms of Action and Scientific Justification: Psoriasis Herb Spray

Liver and Gastrointestinal Tract. Anthraquinones from Senna alata and phenolic compounds from Cuscuta reflexa exhibit antioxidant and membrane-stabilizing action through suppression of lipid peroxidation and activation of antioxidant defense enzyme systems (glutathione peroxidase, superoxide dismutase). These effects are additive and contribute to reducing the toxic load on the liver. Alkaloids from Stephania venosa modulate cytochrome enzymes, participating in the regulation of xenobiotic metabolism.

Reference: PubMed (PMID: 32718638), SpringerLink (doi:10.1007/s11418-017-1106-2).

Immune System. Coumarinolignans from Cleome viscosa and alkaloids from Stephania venosa reduce the expression of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) through blockade of NF-κB and MAPK signaling pathways. Flavonoids from Cuscuta reflexa modulate macrophage and neutrophil activity, enhancing phagocytosis and regulating the release of inflammatory mediators. The combination of these compounds forms potentiating immunomodulation, ensuring a balance between pro- and anti-inflammatory reactions.

Reference: PMC (PMCID: PMC8686849), ScienceDirect (doi:10.1016/j.phymed.2020.153311).

Nervous System. Alkaloids from Stephania venosa possess sedative and neuromodulating properties, mediated by influence on GABAergic transmission and partially on cholinergic synapses. Phenolic compounds from Cleome viscosa and Cuscuta reflexa demonstrate antioxidant activity in neuronal models, protecting cells from oxidative stress. This effect is protective and modulating in nature.

Reference: Wiley Online Library (doi:10.1002/ptr.6219), Semantic Scholar (Corpus ID: 208206398).

Endocrine and Metabolic Regulation. Flavonoids and coumarins of the product's components participate in the regulation of carbohydrate and lipid metabolism through inhibition of α-glucosidase and modulation of the PPAR-γ signaling pathway. Anthraquinone compounds additionally exhibit lipotropic properties, reducing triglyceride accumulation in liver cells. The nature of the interaction is additive, with a systemic level of action.

Reference: ScienceDirect (doi:10.1016/j.jep.2017.05.021), PubMed (PMID: 35662384).

Skin and Epidermal Structures. Anthraquinones from Senna alata inhibit the growth of dermatophytes by damaging fungal cell walls and suppressing their enzymatic activity. Flavonoids from Cleome viscosa and Cuscuta reflexa enhance the antioxidant protection of the skin, while mineral components of Cuttle Bone create a tissue-specific environment for accelerated epithelialization. The interaction is potentiating and additive, aimed at modulating local inflammatory and reparative processes.

Reference: PMC (PMCID: PMC7344450), SpringerLink (doi:10.1007/s11418-019-01354-3).