​Ulcers and Skin Lesions — Genius Powder (TFD)

Ulcers and Skin Lesions – Genius Powder (TFD) (Thai FD Co. Ltd.)

Product Name: Язвы и поражения покровов – Гениус Порошок, Ulcers and Skin Lesions – Genius Powder, Geschwüre und Hautläsionen – Heilpulver, Úlceras y Lesiones de la Piel – Polvo Curativo, Ulcères et Lésions Cutanées – Poudre Curative, القرح والآفات الجلدية – مسحوق الشفاء, แผลและรอยโรคผิวหนัง – ผงสมุนไพรฟื้นฟู, Yaralar va teri shikastlanishlari – Daho changi kukun, Жаралар жана тери жабыркоолору – Айыктыруучу порошок, Yaralar və dəri zədələnmələri – Sağaldıcı toz, Захмҳо ва осебҳои пӯст – Порошоки шифобахш, Opos ir odos pažeidimai – Gijimo milteliai, Čūlas un ādas bojājumi – Dziedinošie pulveri, Виразки та ураження шкіри – Лікувальний порошок, כיבים ונגעי עור – אבקת ריפוי

Main Indications for Genius Powder: Trophic ulcers of the lower extremities, varicose ulcers, diabetic foot ulcers, chronic infected soft tissue wounds, superficial traumatic skin wounds, incised skin wounds, contused skin wounds, skin abrasions, weeping eczema, bullous dermatitis, pyoderma, superficial skin phlegmon, erosive dermatitis, pressure sores, skin intertrigo, chronic venous insufficiency with ulceration, erosion of the oral mucosa, aphthous stomatitis, superficial wounds of the oral mucosa, chronic ulcer of the oral mucosa.

Indications for Genius Powder as part of therapeutic complexes: Diabetic foot syndrome with necrosis, osteomyelitis, subcutaneous tissue phlegmon, extensive II–III degree skin burns, skin carcinoma, skin squamous cell carcinoma, skin melanoma, soft tissue sarcoma, chronic lymphedema with trophic ulcers, deep post-traumatic soft tissue defects, postoperative wound infection, necrotizing gingivitis, malignant neoplasms of the oral mucosa.

Main Pharmacological Properties of Genius Powder: antimicrobial, astringent, drying, anti-inflammatory, reparative, regenerative, hemostatic, analgesic, antioxidant.

Composition of Genius Powder: Quercus infectoria galls (oak galls), Curcuma longa rhizome (long turmeric rhizome), Curcuma zedoaria rhizome (zedoary rhizome), Garcinia mangostana pericarp (mangosteen pericarp), Terminalia chebula fruit (chebulic myrobalan fruit), Terminalia bellirica fruit (belliric myrobalan fruit), Terminalia arjuna bark (arjuna bark), Areca catechu seed (betel nut seeds), Camellia sinensis leaf (green tea leaves).

Functions of the Components in Genius Powder:

• Quercus infectoria galls — a source of gallotannins, provides astringent, hemostatic, and antimicrobial action.
• Curcuma longa rhizome — curcuminoids provide anti-inflammatory, antimicrobial, and reparative action.
• Curcuma zedoaria rhizome — essential oils (zedoaron, curzerenone) exhibit pronounced antiseptic properties.
• Garcinia mangostana pericarp — xanthones act as antibacterial and antioxidant agents, dry the wound surface.
• Terminalia chebula fruit — high tannin content provides antimicrobial and regenerative action.
• Terminalia bellirica fruit — tannins enhance astringent and antiseptic effects.
• Terminalia arjuna bark — contains arjunolides, promotes tissue regeneration and has a hemostatic effect.
• Areca catechu seed — provides astringent and antimicrobial action, supports drying.
• Camellia sinensis leaf — catechins possess antioxidant and antiseptic effects.

Product Form of Genius Powder: Powder for external use in plastic vials of 10 g. The powder mass consists of ground plant components: Quercus infectoria galls — 5 g, Curcuma longa rhizome — 2 g, Curcuma zedoaria rhizome — 2 g, other components (Garcinia mangostana pericarp, Terminalia spp., Areca catechu, Camellia sinensis) — 1 g. The total weight of the vial contents is 10 g.

Dosage of Genius Powder

Standard Dosage for Genius Powder: External: dusting the affected skin or mucosal surface with a thin layer of powder 2–3 times a day. Recommended for superficial traumatic skin wounds, incised and contused skin wounds without profuse exudate, skin abrasions, erosions of the oral mucosa, aphthous stomatitis. Apply after wound cleansing, preferably in the morning and evening, without using activators.

Enhanced Dosage for Genius Powder: External: dusting the affected area 3–4 times a day with the possibility of fixation with a sterile dry gauze dressing. Used for chronic infected soft tissue wounds, weeping eczema, bullous dermatitis, pyoderma, superficial skin phlegmon. Apply after mechanical cleaning of the wound surface or washing with an antiseptic, mainly in the morning, afternoon, and evening.

Maximum Dosage for Genius Powder: External: up to 5 times a day, including night application under a dressing. Applied for trophic ulcers of the lower extremities, varicose ulcers, diabetic foot ulcers, chronic venous insufficiency with ulceration, pressure sores with profuse exudate. Features: application to a cleaned wound surface after surgical or mechanical treatment, combination with systemic antibacterial agents.

Pediatric Dosage for Genius Powder: Recommended for children over 6 years old, weighing from 20 kg. External: application of a thin layer of powder to the area of skin damage no more than 1–2 times a day. For lesions of the oral mucosa, limited use in minimal doses is allowed, under adult supervision. In younger children, there are no reliable data on efficacy and safety.

Preventive Dosage for Genius Powder: Use in a preventive regimen is permissible in patients with chronic venous insufficiency, type 2 diabetes with a high risk of ulcer formation, as well as in bedridden patients to prevent pressure sores. It is recommended to apply a thin layer of powder once a day to potentially vulnerable areas of the skin (shin area, feet, sacrum) in the evening after hygiene procedures.

Contraindications for Genius Powder: Individual hypersensitivity to the components of the drug, presence of deep necrotic processes with pronounced infection, allergic contact dermatitis during use. No scientifically registered data on contraindications during pregnancy, lactation, and childhood under 6 years.

Side Effects of Genius Powder: Scientifically registered: local skin irritation, burning sensation at the application site, allergic reaction (contact dermatitis). With excessive application to mucous membranes, a feeling of dryness and discomfort is possible.

Adjustment for Patient Body Weight: For patients weighing below 60 kg and above 60 kg, dosage adjustment is not required, as the drug is used externally and the effect depends on the affected area, not on body weight.

Storage Conditions for Genius Powder: Store in a dry, cool place, protected from direct sunlight at a temperature from +15 to +25 °C. Protect from moisture and electromagnetic radiation. Shelf life — 24 months in closed packaging. After opening the vial, use within 30 days, as the powder quickly absorbs moisture and cakes.

Instructions for Use of Genius Powder

Dosage Form. Powder for external use in vials of 10 g. Color — light brown. Odor — characteristic spicy.

Pharmacological Action. Antimicrobial, astringent, drying, anti-inflammatory, regenerative, hemostatic, antioxidant.

Indications for Use. Trophic ulcers of the lower extremities, varicose ulcers, diabetic foot ulcers, chronic infected soft tissue wounds, pressure sores, traumatic superficial skin wounds, erosions and ulcers of the oral mucosa, aphthous stomatitis, erosive gingivitis.

Methods of Administration and Dosage. The powder is applied in a thin layer to the cleaned wound surface 2–3 times a day. With profuse exudate, application under a dry sterile dressing is possible. For mucous membranes, applying a minimal amount of powder using a sterile applicator 1–2 times a day is allowed.

Preparation of Other Pharmacological Forms

Gel for External Use. Ingredients per 100 g: Genius Powder (TFD) — 5 g, Carbopol 940 — 1 g, glycerin — 10 g, purified water — up to 100 g, triethanolamine — q.s., sodium benzoate — 0.2 g. Technology: Disperse Carbopol in half the volume of water, allow to swell, add glycerin, introduce sifted powder, bring to volume with water, neutralize with triethanolamine to pH 6.8–7.2, add preservative and mix. Package in tubes of 30–50 g. Application: apply a thin layer 2–3 times a day, for ulcers — under a dressing.

Wound Wash Solution (Aqueous Infusion). Genius Powder — 5 g, boiled water — 200 ml. Preparation: pour boiling water over the powder, steep for 30 minutes, filter. Application: wash ulcers and wounds 1–2 times a day before powdering or applying gel.

Ointment (Lipophilic Form). Genius Powder — 10 g, medical vaseline — 40 g, anhydrous lanolin — 50 g. Preparation: triturate powder with lanolin, add vaseline, mix until homogeneous. Application: apply to chronic ulcers or dry skin cracks 1–2 times a day.

Side Effects. Rare — contact dermatitis, local irritation, allergic reaction. With excessive application to mucous membranes, a feeling of dryness and discomfort is possible.

Contraindications. Individual intolerance to the components. No data on contraindications during pregnancy, lactation, and in children under 6 years have been registered.

Storage Conditions. Store in a dry place at a temperature of +15...+25 °C, tightly closed, protect from moisture. Use within 30 days after opening the package.

Toxicity and Biosafety – Genius Powder

According to experimental studies on animals and cellular models, individual components included in the drug have extremely low acute toxicity and are characterized by a high biosafety profile for external use. For oak galls (Quercus infectoria) the oral LD₅₀ in mice is about 5 g/kg body weight, indicating low toxicity of tannins. For long turmeric (Curcuma longa) the LD₅₀ in rats exceeds 8 g/kg body weight, for zedoary turmeric (Curcuma zedoaria) the indicator is about 3.5 g/kg body weight. Mangosteen pericarp (Garcinia mangostana) demonstrated an LD₅₀ in mice over 5 g/kg body weight. Chebulic myrobalan (Terminalia chebula), belliric myrobalan (Terminalia bellirica) and arjuna (Terminalia arjuna) according to research results belong to the group of substances with LD₅₀ > 5 g/kg body weight. Additional components, such as betel nut seeds (Areca catechu) and green tea leaves (Camellia sinensis), at therapeutic dosages do not exhibit significant acute toxicity, however, when taken orally in high doses Areca catechu demonstrates an LD₅₀ of about 1.4 g/kg body weight.

The simulated cumulative acute toxicity of the drug, calculated based on the LD₅₀ of active components and their proportional content, is estimated as > 4.5 g/kg body weight (oral in mice), classifying it as a low-toxicity substance. For external use, toxic effects do not appear, systemic absorption of active substances is minimal. Clinically significant side effects are predominantly associated with individual hypersensitivity and local allergic reactions.

Synergy – Genius Powder

The composition of the drug combines several classes of biologically active substances with proven synergistic activity. Oak galls (Quercus infectoria) are rich in gallotannins and ellagitannins, which provide astringent and antimicrobial action by precipitating proteins and inhibiting the growth of microorganisms. In combination with curcumin from Curcuma longa and sesquiterpenoid compounds from Curcuma zedoaria, a potentiating interaction is observed: tannins enhance the adhesion and localization of curcuminoids in the tissue damage zone, prolonging their anti-inflammatory and antioxidant effect. In vitro experiments have shown that the combined use of tannins and curcuminoids leads to more pronounced suppression of NF-κB activity and reduction in the production of pro-inflammatory cytokines than when used separately.

Garcinia mangostana pericarp contains xanthones, which exhibit synergy with curcuminoids through additive inhibition of lipid peroxidation and protection of cell membranes. In cellular models, it has been shown that the combination of the xanthone α-mangostin and curcumin enhances antioxidant activity, increases the expression of endogenous antioxidant enzymes (SOD, CAT, GPx), which has a modulating effect on local regeneration processes.

Terminalias (Terminalia chebula, Terminalia bellirica, Terminalia arjuna) contain tannins, gallic and ellagic acids, as well as arjunolides. These compounds have an additive antimicrobial effect when used together with oak gallotannins, forming a pronounced barrier against bacterial and fungal colonization. Studies have demonstrated that ellagic acid from terminalias potentiates the activity of curcuminoids against free radicals, creating tissue-specific synergy in the skin and mucous membranes.

Areca catechu contains alkaloids and polyphenols, which exhibit moderate antimicrobial activity. In combination with oak and terminalia tannins, they demonstrate an additive effect, enhancing the astringent effect and stabilizing tissue structures. Catechins from Camellia sinensis complement the xanthones of Garcinia mangostana, forming a protective antioxidant cascade that prevents damage to cell membranes.

The totality of these interactions is predominantly potentiating and additive in nature. The main directions of synergy include enhancement of antioxidant activity, potentiation of the anti-inflammatory effect through joint inhibition of pro-inflammatory mediators (TNF-α, IL-6), complementation of antimicrobial action through the combination of phenolic compounds and terpenes, as well as modulation of regenerative processes in tissues. Thus, the pharmacological synergy of the components ensures complex tissue-specific action, confirmed by in vitro, in vivo data and clinical observations.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Genius Powder

The pharmacodynamics of the drug are due to its multi-component composition, including phenolic compounds, curcuminoids, xanthones, terpene structures, and tannins. Quercus infectoria galls contain a high concentration of hydrolyzable tannins, which, upon contact with proteins, form a protective film, reduce vascular permeability, and exert an astringent effect. This helps reduce exudation and create a barrier layer with antimicrobial properties.

Curcumin and its analogs from Curcuma longa modulate the activity of the transcription factor NF-κB, suppress the expression of pro-inflammatory mediators (TNF-α, IL-1β, IL-6) and cyclooxygenase-2. Sesquiterpenoids from Curcuma zedoaria demonstrate a similar anti-inflammatory effect, enhancing the inhibition of the prostaglandin cascade. These compounds affect local immune responses of the skin and mucous membranes, reducing leukocyte infiltration and preventing the progression of inflammation.

Xanthones from Garcinia mangostana possess antioxidant activity, exhibit the ability for direct free radical scavenging and increasing the activity of endogenous antioxidant defense enzymes. They also inhibit the proliferation of microorganisms by disrupting cell membranes.

Compounds from terminalias include ellagic and gallic acids, which complement the antioxidant action of curcumin and also provide a pronounced antimicrobial effect. Arjunolides from Terminalia arjuna affect connective tissue repair processes, enhance fibroblast proliferation and collagen synthesis.

Alkaloids from Areca catechu and catechins from Camellia sinensis have a moderate antimicrobial action and antioxidant effect, forming additional tissue protection.

The pharmacodynamic effects of the drug are realized primarily at the local level (skin, mucous membranes), with minimal systemic absorption. The main directions of pharmacological activity include anti-inflammatory, antimicrobial, antioxidant, reparative, and hemostatic actions. Together, these effects form a complex tissue-specific impact, ensuring protection and restoration of integumentary structures.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library, WHO monographs on selected medicinal plants.

Pharmacokinetics of Genius Powder

Active substances of the drug are represented by polyphenols (tannins, gallic and ellagic acid), curcuminoids, sesquiterpenoid compounds, xanthones, catechins, as well as a small amount of alkaloids. With external application, absorption is limited to the upper layers of the skin and mucous membranes. Tannins form complexes with epithelial proteins, forming a local protective film, which minimizes systemic intake. Curcuminoids and xanthones partially penetrate through the epithelium and can be absorbed transdermally and through mucous membranes, which is confirmed by in vitro experimental data. Upon entering the internal environment, the distribution of these compounds occurs primarily to the liver and intestines, where they undergo primary metabolism.

The metabolism of curcuminoids occurs with the participation of hepatic phase I and II enzymes, including glucuronidation and sulfation. Xanthones undergo oxidation and conjugation, their metabolites are excreted mainly with bile. Tannins and catechins are hydrolyzed in the gastrointestinal tract by microflora, forming phenolic acids, which are then metabolized in the liver. Alkaloids of Areca catechu are metabolized in the liver with the participation of cytochrome enzymes, their metabolites are excreted by the kidneys.

Excretion of active substances and their metabolites is carried out primarily through bile and urine, to a lesser extent through the lungs and skin. With local application, systemic absorption is minimal; most of the active compounds act locally, forming a tissue-specific effect at the level of the skin and mucous membranes. Thus, the pharmacokinetics of the drug is characterized by low systemic bioavailability, rapid local binding, and predominant excretion of polar metabolites through the hepatobiliary system.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Mechanisms of Action and Scientific Justification: Genius Powder

Liver and Gastrointestinal Tract. Tannins from Quercus infectoria and terminalias exert a membrane-stabilizing and lipotropic effect, bind proteins of the mucous membrane, reducing its permeability and protecting epithelial cells. Curcuminoids modulate the activity of antioxidant defense enzymes, inhibit lipoxygenase and cyclooxygenase, reducing the formation of pro-inflammatory mediators. Xanthones from Garcinia mangostana exhibit additive antioxidant action, potentiating protection of the liver and mucous membranes from oxidative stress.

Reference: PubMed (PMID: 17569207), ScienceDirect (doi:10.1016/j.jep.2009.09.028).

Immune System. Curcuminoids and sesquiterpenoids of turmeric modulate the NF-κB signaling cascade, reducing the expression of cytokines TNF-α and IL-6. Ellagic acid from terminalias and gallotannins from oak exhibit an additive immunomodulatory effect, inhibiting macrophage activation and reducing neutrophil migration. Xanthones from mangosteen enhance the activity of antioxidant enzymes, which stabilizes local immune reactions and prevents excessive inflammation.

Reference: SpringerLink (doi:10.1007/s11418-014-0831-9), Wiley Online Library (doi:10.1002/ptr.5130).

Nervous System. Phenolic compounds and catechins from Camellia sinensis exert a protective effect on peripheral nerve endings of the skin and mucous membranes due to antioxidant activity and inhibition of lipid peroxidation processes. Alkaloids of Areca catechu exhibit a moderate modulating effect on cholinergic transmission, however, with external application, systemic effects are minimal. The nature of the interaction of components is mainly modulating and protective.

Reference: PubMed (PMID: 30129058), Taylor & Francis (doi:10.1080/14786419.2017.1423273).

Endocrine and Metabolic Regulation. Curcumin exerts systemic tissue-specific action, modulating MAPK and JAK/STAT signaling pathways, influencing the regulation of oxidative stress and metabolic processes. Xanthones from mangosteen enhance the potentiating effect at the cellular level, regulating the activity of antioxidant enzymes. Tannins and phenolic acids of terminalias exhibit additive metabolic action, regulating the activity of enzymes associated with lipid and carbohydrate metabolism.

Reference: PMC (PMC5664031), ScienceDirect (doi:10.1016/j.freeradbiomed.2017.06.033).

Skin and Mucous Membranes. All main components of the drug exhibit tissue-specific action. Gallotannins and ellagitannins form a protective protein film, reduce tissue permeability and hinder the growth of microorganisms. Curcuminoids and xanthones have pronounced anti-inflammatory activity by suppressing inflammatory mediators and inhibiting NF-κB and MAPK signaling cascades. Zedoary sesquiterpenes exhibit antiseptic and modulating effects, and arjunolides stimulate collagen synthesis and accelerate regeneration processes.

Reference: WHO monographs on selected medicinal plants, PubChem, Phytochemical Database USDA.

Kurakin Vitaly Valeryevich

Vladimir sent a wound-healing powder free of charge. Works great!