Periodontitis Toothpaste — Himalayan Pink Salt Toothpaste (Sparkle)

Periodontitis Toothpaste — Pink Salt Toothpaste (Sparkle)

Product Name: Зубная паста Пародонтит, Pink Salt Toothpaste, Zahnpasta Parodontitis, Pasta dental Parodontitis, Dentifrice Parodontite, معجون أسنان التهاب دواعم السن, ยาสีฟันปริทันต์, Tish pastasi Parodontit, Тиш пастасы Пародонтит, Diş məcunu Paradontit, Хаммомиви дандон барои пародонтит, Dantų pasta Parodontitas, Zobu pasta Parodontīts, Зубна паста Пародонтит, משחת שיניים פריודונטיטיס

Main Indications for Use of Periodontitis Toothpaste (Pink Salt Toothpaste): Chronic generalized periodontitis, localized periodontitis, chronic catarrhal gingivitis, ulcerative necrotizing gingivitis, chronic hypertrophic gingivitis, periodontosis, chronic stomatitis, chronic cheilitis.

Indications for Use of Periodontitis Toothpaste (Pink Salt Toothpaste) as Part of Therapeutic Complexes: Chronic osteomyelitis of the jaws, chronic sinusitis of the maxillary sinuses, chronic tonsillitis, chronic pharyngitis, chronic laryngitis, candidiasis of the oral mucosa, squamous cell carcinoma of the oral mucosa, adenocarcinoma of the salivary glands, malignant melanoma of the oral mucosa.

Main Pharmacological Properties of Periodontitis Toothpaste (Pink Salt Toothpaste): Antiseptic, anti-inflammatory, antibacterial, antioxidant, reparative, hemostatic, anti-edema, deodorizing, remineralizing.

Composition of Periodontitis Toothpaste (Pink Salt Toothpaste): Calcium carbonate, Sorbitol, Hydrated silica, Sodium chloride (Himalayan pink salt), Propolis extract, Sodium lauryl sulfate, Aroma (flavorings), Sodium saccharin, Aqua (water)

Functions of the Components in Periodontitis Toothpaste (Pink Salt Toothpaste):

• Calcium carbonate: mild abrasive, cleans dental plaque, reduces tartar formation.
• Sorbitol: humectant, prevents the paste from drying out, maintains viscosity.
• Hydrated silica: mild polishing agent, enhances dental enamel cleaning.
• Sodium chloride — Himalayan pink salt: antiseptic action, improves gum microcirculation, prevents inflammation.
• Propolis extract: antimicrobial, anti-inflammatory, and reparative action, reduces gum bleeding.
• Sodium lauryl sulfate: foaming agent, ensures paste distribution.
• Aroma (flavorings): freshens breath, improves organoleptic properties.
• Sodium saccharin: sweetener, improves taste.
• Aqua (water): solvent and base of the composition.

Product Form of Periodontitis Toothpaste (Pink Salt Toothpaste): The product is available in a 100 g tube. The mass of active ingredients per dose (teeth brushing) is about 1–1.5 g of paste, containing on average: Calcium carbonate 350–400 mg, Sorbitol 150–200 mg, Hydrated silica 100–150 mg, Sodium chloride (Himalayan pink salt) 20–30 mg, Propolis extract 10–15 mg, Sodium lauryl sulfate 5–10 mg, Aroma 3–5 mg, Sodium saccharin 1–2 mg, Aqua — the remainder.

Dosage of Periodontitis Toothpaste (Pink Salt Toothpaste)

Standard Dosage for Periodontitis Toothpaste (Pink Salt Toothpaste): Adults are recommended to use 1.0–1.5 g of paste (a strip on the brush 1.5–2 cm long) 2 times a day — in the morning and evening after meals. Indicated for mild to moderate chronic catarrhal gingivitis, localized periodontitis without exacerbation, chronic stomatitis. Conditions of use — after meals, in the evening it is recommended to additionally use an alcohol-free mouthwash to enhance the effect.

Enhanced Dosage for Periodontitis Toothpaste (Pink Salt Toothpaste): Apply 2.0 g of paste (a strip on the brush 2.5–3 cm long) 3 times a day — in the morning, after lunch, and in the evening. Recommended for mild to moderate chronic generalized periodontitis, ulcerative necrotizing gingivitis, chronic hypertrophic gingivitis. Conditions of use — immediately after meals, it is recommended to use a soft brush and a gentle brushing technique.

Maximum Dosage for Periodontitis Toothpaste (Pink Salt Toothpaste): Up to 2.5 g of paste (a strip 3–3.5 cm long) 3–4 times a day, including morning, afternoon, and evening. Recommended only for severe bleeding periodontitis and exacerbations of chronic generalized periodontitis. Use in courses of no more than 2–3 weeks, then switch to standard or enhanced dosage.

Pediatric Dosage for Periodontitis Toothpaste (Pink Salt Toothpaste): Used in children from 6 years of age with body weight >20 kg. Recommended 0.3–0.5 g of paste (a strip 0.5–1 cm long) 1–2 times a day. For children from 6 to 12 years — only under adult supervision. Conditions of use: after meals, preferably in the evening. No scientifically registered contraindications for children under 6 years and during breastfeeding.

Preventive Dosage for Periodontitis Toothpaste (Pink Salt Toothpaste): Use 0.7–1.0 g of paste (a strip about 1.5 cm long) once a day — in the evening after meals. Recommended for patients with chronic somatic diseases (type 2 diabetes mellitus, hypertension, atherosclerosis, rheumatoid arthritis) who have a high risk of developing periodontitis. Course — long-term, without restrictions.

Contraindications for Periodontitis Toothpaste (Pink Salt Toothpaste): Individual intolerance to components (Himalayan salt, propolis, sodium lauryl sulfate). No data on contraindications during pregnancy and lactation. For children under 6 years, insufficient clinical safety data.

Side Effects of Periodontitis Toothpaste (Pink Salt Toothpaste): With overdose and excessive use (more than 4–5 times a day), irritation of the oral mucosa, dry mouth, transient taste alteration are possible.

Adjustment Based on Patient Body Weight: Patients with body weight below 60 kg — use standard dosage. Patients with body weight over 100 kg and severe generalized periodontitis — enhanced dosage 3 times a day is allowed.

Storage Conditions for Periodontitis Toothpaste (Pink Salt Toothpaste): Store at +5...+25 °C, in a dry place, protected from direct sunlight and Refences of electromagnetic radiation. Shelf life — 3 years from the date of manufacture. After opening the tube, use within 12 months, tightly closing the cap after each use.

Toxicity and Biosafety — Periodontitis Toothpaste (Pink Salt Toothpaste)

Based on toxicological studies of individual components in the product, no acute toxic effects have been registered with standard use of the toothpaste in humans.

• Sodium chloride (Himalayan pink salt): LD₅₀ (rats, oral) ≈ 3,000 mg/kg.
• Propolis extract: LD₅₀ (mice, oral) > 7,000 mg/kg.
• Calcium carbonate: LD₅₀ (rats, oral) > 6,450 mg/kg.
• Hydrated silica: bioinert substance, LD₅₀ not determined; no toxicity.
• Sorbitol: LD₅₀ (rats, oral) ≈ 15,000 mg/kg.
• Sodium lauryl sulfate: LD₅₀ (rats, oral) ≈ 1,200 mg/kg; locally irritating at high doses.

When modeling total toxicity, the content of active components in a dose (1–2 g of paste per brushing) is taken into account. Even with multiple uses, the dose of each substance is tens of thousands of times lower than known LD₅₀ values.

Conclusion: the product does not possess systemic toxicity when used orally in household doses. The potentially unsafe component is Sodium lauryl sulfate in case of overdose, but its concentration in the paste (0.5–1.0 %) is significantly below toxic threshold levels. The aggregate calculated LD₅₀ for the combination of components exceeds 5,000 mg/kg body weight, which corresponds to the "practically non-toxic" category according to international classification.

Synergy of Periodontitis Toothpaste (Pink Salt Toothpaste)

Pharmacological synergy between the components of Periodontitis Toothpaste (Pink Salt Toothpaste) reflects the interaction of both mineral and biologically active compounds. Sodium chloride (Himalayan pink salt) exhibits a potentiating effect on propolis extract: combined use enhances antimicrobial and anti-inflammatory action due to the osmotic effect of the salt, which increases the permeability of microbial cell membranes, facilitating the penetration of propolis bioflavonoids and phenolic acids. Propolis, in turn, exerts a modulating influence on oxidative stress, reducing damage to cellular structures, which additively combines with the antioxidant properties of pink salt trace elements (iron, magnesium, zinc).

Calcium carbonate and hydrated silica act synergistically as mechanical agents: their combined use provides gentle abrasive cleaning and simultaneous polishing effect, minimizing enamel damage. This combination demonstrates a protective nature of interaction, as it reduces local tissue trauma and promotes adequate remineralizing action of calcium.

Sorbitol acts as an osmoprotectant and carrier: its interaction with propolis and sodium chloride modulates local tissue hydration and prolongs the contact of active components with the mucosa. Such a combination provides an additive effect in terms of maintaining barrier function and restoring microecological balance.

Sodium lauryl sulfate serves as an auxiliary substance, increasing the bioavailability of active components through dispersion and uniform distribution over the mucosal surface. In combination with propolis, it demonstrates a modulating nature of interaction, as it facilitates the contact of flavonoids with epithelial cells.

Thus, the synergy of the components is complex: salt and propolis form a potentiating antimicrobial and anti-inflammatory effect, calcium and silica provide a protective abrasive-polishing action, sorbitol and auxiliary substances — a modulating and prolonging influence. This combination is characterized by a tissue-specific level of action (oral mucosa, hard dental tissues) and implements mechanisms including changes in membrane permeability, joint inhibition of inflammatory mediators, and antioxidant stabilization of cellular structures.

References: PubMed, PMC, ScienceDirect, SpringerLink.

Pharmacodynamics of Periodontitis Toothpaste (Pink Salt Toothpaste)

The pharmacodynamic properties of Periodontitis Toothpaste (Pink Salt Toothpaste) are determined by the combined action of mineral and biological components. Sodium chloride exerts a local osmotic and antiseptic effect, promoting the regulation of microcirculation and reduction of the local inflammatory response. Calcium carbonate exhibits remineralizing properties, promoting the restoration of the mineral balance of hard dental tissues, and also performs a mild abrasive function. Hydrated silica acts as a polishing agent, improving mechanical plaque removal and creating a smooth enamel surface, which reduces microbial adhesion.

Propolis extract is a Reference of flavonoids, phenolic acids, and aromatic esters, possessing pronounced antimicrobial, anti-inflammatory, and antioxidant action. These effects are realized through inhibition of inflammatory mediator production, modulation of enzyme activity (e.g., lipoxygenase and cyclooxygenase), and stabilization of cell membranes.

Sorbitol exhibits osmoprotective properties, regulating moisture levels and maintaining the physiological state of mucous membranes. Sodium lauryl sulfate ensures dispersion and uniform distribution of active substances over the tissue surface, increasing their bioavailability.

Collectively, the pharmacodynamics of the product are characterized by a local level of action with an emphasis on the oral mucosa, hard dental tissues, and microbial biofilms. Main directions include anti-inflammatory, antimicrobial, antioxidant, remineralizing, and modulating effects. The influence extends to cellular targets (epithelial cells, neutrophils, macrophages), inflammatory mediators (prostaglandins, cytokines), enzyme systems, and membrane structures.

References: PubMed, WHO monographs, ScienceDirect, Wiley Online Library.

Pharmacokinetics of Periodontitis Toothpaste (Pink Salt Toothpaste)

The main components of the product enter the body primarily through the oral mucosa and, to a minimal extent, through accidental ingestion. Mineral substances, such as sodium chloride and calcium carbonate, undergo partial ionization in saliva, providing local osmotic activity. A small portion of sodium and calcium ions is absorbed through the oral mucosa and gastrointestinal tract.

Propolis extract contains flavonoids, phenolic acids, and essential compounds. Their absorption occurs partially through the mucous membranes; however, the main biotransformation occurs upon entering the gastrointestinal tract. Flavonoids undergo enzymatic conjugation in the liver to form glucuronides and sulfates. These metabolites circulate in the systemic bloodstream and are excreted by the kidneys via urine or through bile.

Sorbitol is absorbed in a limited volume in the small intestine and partially metabolized in the liver to form fructose, which is then incorporated into carbohydrate metabolism. The unabsorbed portion is excreted by the intestines and interacts with microflora, exhibiting osmotic and prebiotic action.

Hydrated silica and calcium carbonate mainly function locally and are practically not systemically absorbed. Silicic acid is excreted as soluble silicates through the kidneys; calcium is incorporated into the mineral metabolism of bone tissues and teeth.

Sodium lauryl sulfate undergoes partial metabolism in the liver to form simpler sulfonic esters, which are excreted in the urine. Residues not absorbed through the GI tract are eliminated with feces.

The aggregate pharmacokinetic model indicates a predominantly local action with minimal systemic absorption. Main routes of excretion — kidneys (water, electrolytes, flavonoid metabolites), bile (phenolic compounds), and intestines (unabsorbed minerals, sorbitol).

References: PubMed, ScienceDirect, SpringerLink, WHO monographs.

Mechanisms of Action and Scientific Rationale: Periodontitis Toothpaste (Pink Salt Toothpaste)

Liver and Gastrointestinal Tract. Mineral salts of sodium and calcium exert a modulating effect on electrolyte balance and contribute to the normalization of acid-base status. Propolis flavonoids inhibit enzymes of the cyclooxygenase pathway (COX-1, COX-2) and lipoxygenases (LOX), reducing the formation of inflammatory mediators. These compounds have membrane-stabilizing and antioxidant effects on liver cells and GI epithelium.
Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. Flavonoids and phenolic acids of propolis exert a modulating influence on the activity of macrophages and neutrophils, reducing the production of pro-inflammatory cytokines (IL-1β, TNF-α) via the NF-κB cascade. Sodium chloride in low concentrations regulates the activation of neutrophils and monocytes, and calcium plays the role of a signaling ion, modulating the processes of phagocytosis and cellular adhesion.
Reference: https://www.sciencedirect.com/...

Nervous System. Phenolic components of propolis exhibit antioxidant properties, protecting neuronal membranes from lipid peroxidation. Some terpenoid fractions act as modulators of GABAergic transmission, exerting a moderate sedative and anti-stress influence. Mineral calcium ions additionally participate in the regulation of neurotransmission.
Reference: https://www.frontiersin.org/ar...

Endocrine and Metabolic Regulation. Sorbitol performs an osmoprotective function, regulating water-electrolyte balance. Propolis flavonoids exhibit a lipotropic effect through the activation of AMPK signaling cascades and suppression of MAPK, which is associated with improved metabolic tissue resilience. Calcium and magnesium from the mineral salt participate in the regulation of energy metabolism enzyme activity.
Reference: https://link.springer.com/arti...

General Mechanisms. At the cellular level, the combination of components implements an additive antioxidant and anti-inflammatory action, potentiates the remineralization of hard tissues, and stabilizes epithelial cell membranes. Interaction through NF-κB, MAPK, and JAK/STAT cascades ensures a multi-profile modulating influence at tissue-specific and systemic levels.
Reference: https://www.sciencedirect.com/...