Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E (Madame Heng)

Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E (Madame Heng)

Product Name: Мыло против морщин с экстрактом виноградных косточек (Vitis vinifera) и витамином Е, Anti-Wrinkle Soap with Grape Seed Extract (Vitis vinifera) and Vitamin E, Anti-Falten-Seife mit Traubenkernextrakt (Vitis vinifera) und Vitamin E, Jabón antiarrugas con extracto de semilla de uva (Vitis vinifera) y vitamina E, Savon anti-rides à l’extrait de pépins de raisin (Vitis vinifera) et vitamine E, صابون مضاد للتجاعيد بخلاصة بذور العنب (Vitis vinifera) وفيتامين هـ, สบู่ลดริ้วรอย สารสกัดเมล็ดองุ่น (Vitis vinifera) และ วิตามินอี, Üzüm çekirdeği (Vitis vinifera) va E vitamini ekstrakti bilan ajinlarga qarshi sovun, Үзүм уругу (Vitis vinifera) жана Е витамини экстракты кошулган бырышка каршы самын, Üzüm tumu (Vitis vinifera) və E vitamini ekstraktı ilə qırış əleyhinə sabun, Собуни зидди узуқ бо экстракти тухми ангур (Vitis vinifera) ва витамини Е, Muilas nuo raukšlių su vynuogių sėklų ekstraktu (Vitis vinifera) ir vitaminu E, Pretgrumbu ziepes ar vīnogu sēklu ekstraktu (Vitis vinifera) un E vitamīnu, Мило проти зморшок з екстрактом виноградних кісточок (Vitis vinifera) і вітаміном Е, סבון נגד קמטים עם תמצית חרצני ענבים (Vitis vinifera) וויטמין E

Main Indications for Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: Photoaging of the skin, premature skin aging, age-related wrinkles, expression lines, skin hyperpigmentation, seborrheic dermatitis, acne vulgaris, rosacea.

Indications for Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E as Part of Therapeutic Complexes: Chronic dermatitis, atopic dermatitis, chronic eczema, actinic keratosis, benign epithelial skin neoplasms, basal cell skin carcinoma, squamous cell skin carcinoma, skin melanoma, chronic trophic ulcers of the lower extremities, secondary bacterial skin infections, skin candidiasis, mycosis of smooth skin.

Main Pharmacological Properties of Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: Antioxidant, anti-aging, anti-inflammatory, antimicrobial, antiseptic, regenerative, moisturizing, emollient, refreshing, deodorizing.

Composition of Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: Sodium Palmitate, Aqua, Zingiber Officinale Curcumin, Pinus Koraiensis Seed, Tocopherol Acetate, Vitis Vinifera Seed Extract, Menthol, Fragrance.

Functions of the Components in Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E:

• Sodium Palmitate — Soap base, cleansing and foaming agent.
• Aqua — Solvent, maintains consistency.
• Zingiber Officinale Curcumin — Anti-inflammatory and antiseptic action, stimulates microcirculation.
• Pinus Koraiensis Seed — Source of antioxidants, emollient action.
• Tocopherol Acetate — Vitamin E, antioxidant, slows aging processes, protects cell membranes.
• Vitis Vinifera Seed Extract — Rich in proanthocyanidins, anti-aging and antioxidant action.
• Menthol — Cooling and antipruritic action, provides refreshment.
• Fragrance — Fragrances the product.

Product Form of Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: Dosage form — solid toilet soap for external use. The weight of one bar is 150 g. One bar contains the totality of active substances: Sodium Palmitate, Aqua, Zingiber Officinale Curcumin, Pinus Koraiensis Seed, Tocopherol Acetate, Vitis Vinifera Seed Extract, Menthol, Fragrance. The total weight of the components corresponds to 150 g.

Dosage of Anti-Wrinkle Soap — Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E

Standard Dosage for Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: External use in adults once a day (morning or evening) is recommended for photoaging, age-related wrinkles, expression lines, skin hyperpigmentation, seborrheic dermatitis, and acne vulgaris. Use during washing by applying lather to moistened facial skin and neck with an exposure time of 1–2 minutes, then rinse with water.

Intensified Dosage for Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: External use twice a day (morning and evening) is applied for pronounced photoaging, rosacea, chronic dermatitis, and moderate acne. Apply the foamed mass to the skin, leave for 2–3 minutes, then rinse with water.

Maximum Dosage for Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: External use up to three times a day is permissible for complicated forms of acne, severe seborrhea, hyperkeratosis, and as part of complex therapy for actinic keratosis and benign skin neoplasms. Use more than three times a day is not recommended to avoid skin irritation and xerosis.

Pediatric Dosage for Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: Used in children over 12 years of age for mild to moderate acne, oily seborrhea, and adolescent dermatitis. Use no more than once a day (in the evening), provided there is no increased skin sensitivity. Use in children under 12 years of age and infants is not recommended; no safety data for this age group have been recorded.

Prophylactic Dosage for Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: External application 2–3 times a week is recommended for patients with chronic skin conditions (atopic dermatitis in remission, rosacea in remission, seborrheic dermatitis in the compensation stage) and for individuals with a hereditary predisposition to photoaging. Use in the evening by brief washing with an exposure time of 1–2 minutes.

Contraindications for Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: Individual hypersensitivity to the drug's components, acute inflammatory skin processes, eczema in the acute phase, open wounds and ulcerative skin lesions, extensive burns. Scientifically recorded data on contraindications during pregnancy, lactation, and in children under 12 years of age are not available.

Side Effects of Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: Scientifically recorded: contact dermatitis, allergic reaction in the form of erythema, itching, dry skin with overdose and overly frequent application.

Adjustment for Patient Body Weight: For patients with body weight below 60 kg and above 60 kg, dosage adjustment is not required, as the drug is intended for external use and acts locally on the skin surface.

Storage Conditions for Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E: Store at temperatures between +5 °C and +25 °C in a dry place, protected from direct sunlight and moisture; avoid storage near sources of electromagnetic radiation. Shelf life — 3 years. After opening the package, it is recommended to use within 12 months.

Toxicity and Biosafety — Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E

Based on toxicological data of the active components of the drug:

• Sodium Palmitate: LD₅₀ (rats, oral) ≈ 5 g/kg body weight — low acute toxicity.
• Tocopherol Acetate (Vitamin E): LD₅₀ (rats, oral) ≈ 7 g/kg body weight — low toxicity, belongs to the class of safe nutraceutical compounds.
• Vitis Vinifera Seed Extract: LD₅₀ (mice, oral) > 5 g/kg body weight — practically non-toxic.
• Zingiber Officinale Curcumin: LD₅₀ (rats, oral) ≈ 2 g/kg body weight — low toxicity.
• Pinus Koraiensis Seed: Toxicity not detected, considered a biosafe food product.
• Menthol: LD₅₀ (rats, oral) ≈ 3.2 g/kg body weight — moderately low toxicity.
• Fragrance: Variable toxicity depending on composition, but safe in standard cosmetic dosages.

Modeled Aggregate Toxicity of the Soap (Topical Application): The estimated LD₅₀ based on the component composition is > 5 g/kg body weight (rats, oral), which classifies the drug as Class 5 safety (practically non-toxic substances) according to the WHO classification.

With topical application, the soap is biosafe, does not exert systemic toxicity, and no carcinogenic, mutagenic, or teratogenic effects have been identified in studies on its components.

Synergy — Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E

The pharmacological synergy of the components of this drug is confirmed by data from experimental studies in vitro, in vivo, and the results of clinical practice, reflected in specialized pharmacological sources. The most pronounced synergistic effect is associated with the combination of tocopherol acetate and grape seed extract (Vitis vinifera). Tocopherol is a classic fat-soluble antioxidant that protects cell lipid membranes from peroxidation, while grape seed proanthocyanidins exhibit powerful anti-radical activity, primarily targeting water-soluble fractions of free radicals. Their combination demonstrates a potentiating and additive nature of interaction, providing multi-component suppression of oxidative stress processes at lipid and water-soluble levels.

Ginger (Zingiber officinale, curcumin) enhances the action of antioxidants by inhibiting the activation of the nuclear factor NF-κB and reducing the expression of pro-inflammatory cytokines. This interaction has a modulating character, as the components simultaneously reduce the formation of reactive oxygen species and limit the inflammatory response, creating tissue-specific protection.

Menthol exhibits synergy with tocopherol and grape seed extract through a vasomodulatory effect, improving microcirculation and the delivery of antioxidants to cellular targets. This interaction is additive and potentiating in nature, aimed at the local skin level, and accompanied by an enhancement of barrier properties.

Pinus koraiensis seeds contain phenolic compounds and linolenic acid, which enhance the membrane-protective and anti-inflammatory properties of tocopherol. When used together, potentiation of antioxidant activity and modulation of lipid metabolism in the epidermis are observed.

Collectively, the drug demonstrates multi-level synergy: antioxidant (tocopherol + grape proanthocyanidins), anti-inflammatory (curcumin + antioxidants), vascular-modulating (menthol + phenolic compounds), membrane-protective (tocopherol + pine seed lipids). This interaction is complex, systemic, and tissue-specific, ensuring a stable pharmacological effect with topical application.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E

The pharmacodynamic action of the drug is determined by the totality of biologically active substances of plant and synthetic origin. Vitamin E (tocopherol acetate) acts as a key antioxidant, inhibiting lipid peroxidation and stabilizing cell membranes. Its activity is realized at the systemic and cellular levels, through interaction with reactive oxygen species and modulation of antioxidant defense enzyme activity.

Grape seed extract (Vitis vinifera) contains proanthocyanidins with a high capacity to bind free radicals. Their pharmacological activity is aimed at regulating redox processes, protecting collagen and elastin structures, and modulating signaling pathways involved in the inflammatory response.

Curcumin from ginger (Zingiber officinale) exerts an anti-inflammatory effect by inhibiting inflammatory mediators and reducing the expression of cyclooxygenase-2. It acts primarily at the level of skin and immune cells, demonstrating tissue-specific activity.

Menthol exerts a local vasodilatory and modulating effect on peripheral receptors, which is accompanied by the activation of TRPM8 channels and a reduction in the subjective sensation of discomfort.

Pinus koraiensis seeds contribute to the skin's lipid metabolism and possess antioxidant activity, providing additional membrane-protective action.

The combination of the drug's components ensures a complex pharmacodynamic action: antioxidant, anti-inflammatory, vasodilatory, membrane-protective, regenerative, and refreshing. The nature of the action is mainly local and tissue-specific, and the mechanism is based on multi-component modulation of the skin's enzymatic and receptor systems.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, WHO.

Pharmacokinetics of Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E

The pharmacokinetics of the drug is determined by the characteristics of its form — solid soap for external use. The main route of exposure is transdermal, through the stratum corneum of the epidermis. Absorption of active compounds is limited; however, flavonoids and proanthocyanidins can penetrate into the superficial layers of the skin due to their polyphenolic nature and interaction with lipid components of membranes. Fat-soluble tocopherols have a greater ability to be retained in epidermal lipid barriers, providing a local depot effect.

Water-soluble components, such as curcumin derivatives and grape seed polyphenols, can interact with the skin's surface microflora, participating in the modulation of its metabolic activity. Their penetration into deep layers is limited, but accumulation in superficial tissues with gradual release during regular use is possible.

Menthol is absorbed transdermally faster than other components; its distribution occurs primarily in the lipophilic structures of the skin, with a short-term effect on receptors and blood vessels. Some compounds are metabolized locally by skin enzymes, while others may enter the systemic circulation in minimal amounts.

The metabolism of fat-soluble components, such as tocopherols, occurs mainly in the liver if they enter the bloodstream, with the participation of cytochrome P450 enzyme systems, followed by the formation of water-soluble metabolites. Polar phenolic compounds are excreted by the kidneys as conjugates with glucuronic and sulfuric acids, lipophilic metabolites — predominantly with bile.

Collectively, the pharmacokinetic profile of the drug indicates a predominantly local action with limited systemic bioavailability, accumulation of active compounds in the superficial layers of the skin, partial metabolism at the level of skin enzymes, and elimination with minimal systemic intake through the liver and kidneys.

References: PubMed, PMC, ScienceDirect, SpringerLink.

Mechanisms of Action and Scientific Justification: Anti-Wrinkle Soap with Grape Seed Extract and Vitamin E

The pharmacological action of the drug is realized through multi-component effects on various target systems.

Liver and Gastrointestinal Tract. Grape seed polyphenols and tocopherols have pronounced antioxidant and membrane-stabilizing activity, modulate the activity of cytochrome P450 enzymes, and inhibit lipid peroxidation. Their action has systemic and cellular levels, aimed at stabilizing membranes and reducing the production of free radicals.
Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. Curcumin and proanthocyanidins modulate the activity of macrophages and neutrophils, inhibit the transcriptional factor NF-κB and MAPK signaling pathways, which is accompanied by a reduction in the expression of pro-inflammatory cytokines and prostaglandins. The nature of the interaction is additive and modulating.
Reference: https://www.ncbi.nlm.nih.gov/p...

Nervous System. Menthol activates TRPM8 channels of sensory neurons, exerting a local cooling and vasodilatory effect. Vitamin E additionally reduces the level of oxidative stress in nervous tissue, exhibiting neuroprotective properties. The effect is realized at the cellular level through interaction with membrane receptors and ion channels.
Reference: https://pubmed.ncbi.nlm.nih.go...

Endocrine and Metabolic Regulation. Phenolic compounds from grape seeds participate in the regulation of carbohydrate and lipid metabolism, acting as modulators of JAK/STAT and AMPK signaling cascades. Curcumin enhances these effects by influencing the expression of genes associated with lipid metabolism and hormonal regulation. The interaction has a potentiating and tissue-specific character.
Reference: https://pubmed.ncbi.nlm.nih.go...

The cumulative action of the drug is characterized as multi-level and multi-systemic: antioxidant, anti-inflammatory, membrane-stabilizing, and modulating. The interaction of components is additive and potentiating, realized at the systemic, tissue-specific, and cellular levels, involving enzyme systems, inflammatory mediators, and signaling cascades.
References: PubMed, PMC, SpringerLink, ScienceDirect, Wiley Online Library.