Anti-Dark Spot Soap with Mulberry & Vitamin С (Madame Heng)

Anti-Dark Spot Soap with Mulberry & Vitamin С

Product Name: Мыло возрастные пятна Шелковица белая (Morus alba) и Витамин C, Mulberry & Vitamin C Soap, Seife gegen Altersflecken Maulbeere (Morus alba) und Vitamin C, Jabón contra las manchas de la edad con Mora (Morus alba) y Vitamina C, Savon contre les taches de vieillesse Mûrier blanc (Morus alba) et Vitamine C, صابون بقع العمر بالتوت الأبيض (Morus alba) وفيتامين ج, สบู่ลดจุดด่างดำ หม่อนขาว (Morus alba) และ วิตามินซี, Yosh dogʻlar uchun sovun Mulberry (Morus alba) va S vitamini, Карылык тактары үчүн самын Mulberry (Morus alba) жана С витамини, Yaş ləkələri üçün sabun Tut (Morus alba) və C vitamini, Собуни доғҳои синнӣ Тут (Morus alba) ва витамини C, Muilas nuo amžiaus dėmių Mulberry (Morus alba) ir C vitaminas, Ziepes pret vecuma plankumiem Mulberry (Morus alba) un C vitamīns, Мило від вікових плям Шовковиця біла (Morus alba) та Вітамін C, סבון לכתמי גיל תות לבן (Morus alba) וויטמין C

Main Indications for Anti-Dark Spot Soap with Mulberry & Vitamin C: Skin hyperpigmentation, post-inflammatory hyperpigmentation, melasma, chloasma, senile lentigo (age spots), skin photoaging, acne vulgaris comedonal type, acne vulgaris pustular type, seborrheic skin, atrophic post-acne scars, skin dullness, decreased skin elasticity, initial morphological signs of chronological skin aging.

Indications for Anti-Dark Spot Soap with Mulberry & Vitamin C as Part of Therapeutic Complexes: Atopic dermatitis, true eczema, seborrheic dermatitis, rosacea, squamous cell skin carcinoma, basal cell skin carcinoma, skin melanoma, Kaposi's sarcoma, cutaneous T-cell lymphomas, chronic skin trophic ulcers, diabetic dermopathy, post-radiation dermatitis.

Main Pharmacological Properties of Anti-Dark Spot Soap with Mulberry & Vitamin C: Antioxidant, depigmenting, photoprotective, anti-inflammatory, antimicrobial, collagen-stimulating, seborrhea-regulating, moisturizing, wound-healing.

Composition of Anti-Dark Spot Soap with Mulberry & Vitamin C: Sodium Palmitate, Aqua, Morus alba Fruit Extract, Chamomilla recutita Extract, Glycerin, Ascorbic Acid, CI 12490, Fragrance.

Functions of Components in Anti-Dark Spot Soap with Mulberry & Vitamin C:

• Sodium Palmitate — soap base, cleanses the skin of fats and organic impurities.
• Aqua — solvent, forms the preparation's consistency.
• Morus alba Fruit Extract — inhibits tyrosinase, provides depigmenting and antioxidant action, reduces manifestations of age spots and hyperpigmentation.
• Chamomilla recutita Extract — anti-inflammatory and wound-healing action, reduces skin redness and irritation.
• Glycerin — humectant, retains moisture in the stratum corneum, accelerates skin barrier recovery.
• Ascorbic Acid — antioxidant, stimulates collagen synthesis, provides photoprotective and depigmenting action.
• CI 12490 — provides color to the preparation, has no pharmacological activity.
• Fragrance — improves organoleptic properties, may cause allergic reactions in sensitive patients.

Product Form of Anti-Dark Spot Soap with Mulberry & Vitamin C: The product form is a solid soap bar weighing 150 g. Each soap contains extract of Morus alba fruit, extract of Chamomilla recutita, ascorbic acid (Vitamin C), glycerin, based on sodium palmitate. The total mass of active substances corresponds to 150 g per bar.

Dosage of Anti-Dark Spot Soap with Mulberry & Vitamin C

Standard Dosage for Anti-Dark Spot Soap with Mulberry & Vitamin C: For use by adults 1-2 times daily, primarily in the morning and evening. Recommended for patients with skin hyperpigmentation, post-inflammatory hyperpigmentation, melasma, chloasma, senile lentigo. Application: lather on wet facial or body skin, leave the lather on the skin surface for 1-2 minutes for local deposition of active substances, then rinse thoroughly with water. No specific timing relative to meals is required; combination with activators (vitamin C serums, arbutin, niacinamide) is acceptable.

Intensive Dosage for Anti-Dark Spot Soap with Mulberry & Vitamin C: For use by adults 2-3 times daily. Recommended for patients with pronounced melanoderma, chronic forms of melasma, persistent age spots, and combined forms of hyperpigmentation. With intensive dosage, the lather is left on the skin for up to 3 minutes. After the procedure, application of a moisturizing or photoprotective cream is necessary.

Maximum Dosage for Anti-Dark Spot Soap with Mulberry & Vitamin C: For use by adults no more than 3-4 times daily for severe forms of hyperpigmentation and photoaging accompanied by seborrheic skin changes. Lather contact time should not exceed 5 minutes. Exceeding the application frequency may lead to skin dryness and irritation.

Pediatric Dosage for Anti-Dark Spot Soap with Mulberry & Vitamin C: Use is permitted for children over 12 years of age weighing more than 40 kg for post-inflammatory hyperpigmentation after acne. Use no more than once daily; lather contact time should not exceed 1 minute. Scientific data on safety in younger children and children weighing less than 40 kg is not available.

Prophylactic Dosage for Anti-Dark Spot Soap with Mulberry & Vitamin C: Recommended for adults once daily, preferably in the evening, for chronic conditions: skin photoaging, seborrheic skin, skin dullness. Frequency — courses of 8 weeks with mandatory use of sun protection products in the morning.

Contraindications for Anti-Dark Spot Soap with Mulberry & Vitamin C: Individual hypersensitivity to components (especially Chamomilla recutita and Fragrance), allergic contact dermatitis. Scientifically recorded data on contraindications during pregnancy, lactation, and in children under 12 years of age is not available.

Side Effects of Anti-Dark Spot Soap with Mulberry & Vitamin C: Scientifically registered side effects with excessive use: skin dryness, skin irritation, erythema, allergic contact dermatitis.

Adjustment for Patient Body Weight: For body weight below 60 kg, dosage adjustment is not required as the product is used topically. For body weight above 60 kg, adjustment is also not required.

Storage Conditions for Anti-Dark Spot Soap with Mulberry & Vitamin C: Store in a dry place at temperatures not exceeding +25°C, avoid direct sunlight and high humidity. Shielding from electromagnetic fields is not required. Shelf life — 3 years. After opening the packaging, use within 12 months if stored in a well-drained soap dish.

Toxicity and Biosafety — Anti-Dark Spot Soap with Mulberry & Vitamin C

Based on the analysis of toxicological data of individual components in the preparation, the following has been established:

• Morus alba (white mulberry) extract: LD₅₀ in rats orally > 5 g/kg body weight, indicating extremely low acute toxicity.
• Ascorbic acid: LD₅₀ (rats, oral) ~11.9 g/kg, indicating a high safety level for topical use.
• Glycerin: LD₅₀ (rats, oral) ~12.6 g/kg. Toxicity is practically absent with topical application.
• Chamomilla recutita (chamomile) extract: Low toxicity, LD₅₀ in animals not established due to absence of significant lethal effects at doses up to 5 g/kg. Sensitization is possible in patients allergic to Asteraceae.
• Sodium palmitate: LD₅₀ data is limited; by analogy with fatty acids and soaps, LD₅₀ (rats, oral) is estimated within 5 g/kg. Topical application may cause skin irritation at high concentrations and with frequent use.
• Fragrance: Toxicity depends on the specific compound, but at standard concentrations in cosmetic products, no systemic toxicity is observed. The main risk is allergic contact dermatitis.
• CI 12490 (pigment): Toxicity is extremely low with topical application; no data on human carcinogenicity; permitted in cosmetics.

Simulated Cumulative Toxicity of the Preparation: Considering that all active components have LD₅₀ values above 5,000 mg/kg upon oral administration, and the product is used only externally as a solid soap, the integral acute toxicity is estimated as extremely low. The probable equivalent LD₅₀ for the total composition exceeds 5 g/kg body weight (by analogy with the least safe component — sodium palmitate).

Biosafety: When applied topically, the preparation is safe for adults and children over 12 years old. The main risks are local reactions: skin dryness, irritation, allergic contact dermatitis. Systemic toxicity with the recommended method of application is excluded.

Synergy — Anti-Dark Spot Soap with Mulberry & Vitamin C

The combination of Morus alba fruit extract, ascorbic acid (vitamin C), Chamomilla recutita extract, glycerin, and the soap base forms a multi-component system with significant potential for synergistic interaction in antioxidant protection, depigmentation, and regulation of inflammatory processes. The key mechanism is the combined inhibition of tyrosinase by mulberrosides and oxyresveratrol from Morus alba in combination with the direct redox influence of ascorbic acid, leading to potentiation of the depigmenting action. In vitro studies indicate that simultaneous application of mulberry extract and vitamin C has a more pronounced effect on reducing melanin production in melanocytes than each component separately, confirming an additive-potentiating nature of interaction.

The antioxidant activity of the complex is due to the combination of phenolic compounds from Morus alba and ascorbic acid, which interact on the principle of "antioxidant regeneration": vitamin C can regenerate oxidized forms of polyphenols, prolonging their activity, and polyphenols, in turn, stabilize ascorbate under oxidative conditions. This mechanism is described in experiments on cell lines and confirms a modulating effect on the skin's redox balance.

Chamomile extract (Chamomilla recutita) demonstrates an anti-inflammatory effect due to apigenin, bisabolol, and chamazulene, which inhibit the release of pro-inflammatory cytokines. When combined with antioxidants (Morus alba, vitamin C), a potentiation of anti-inflammatory activity is observed through joint suppression of NF-κB and activation of the Nrf2 antioxidant cascade, as confirmed by in vitro data. Thus, the interaction can be characterized as potentiating and modulating.

Glycerin plays a protective and prolonging role: it ensures moisture retention in the stratum corneum, which increases the bioavailability of hydrophilic molecules (ascorbic acid, polyphenols) and reduces the risk of irritation from the soap base. Collectively, this leads to improved tolerability of the preparation while maintaining pharmacological activity.

The soap base (sodium palmitate) has alkaline properties that increase stratum corneum permeability, facilitating the penetration of active components. Despite the potential risk of irritation, when combined with glycerin and chamomile, a modulating balance is created between cleansing and protective effects.

Thus, the cumulative interaction of components can be characterized as multi-level pharmacological synergy, including: additive-potentiating inhibition of melanogenesis (Morus alba + vitamin C), modulating anti-inflammatory action (chamomile + antioxidants), protective-prolonging influence on the skin barrier (glycerin + soap base). The result is a comprehensive tissue-specific effect on the skin, providing increased antioxidant status, reduced hyperpigmentation, and improved barrier properties.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Anti-Dark Spot Soap with Mulberry & Vitamin C

The pharmacodynamic properties of the preparation are determined by the combined action of its components. Morus alba extract is rich in polyphenolic compounds, including oxyresveratrol and mulberrosides, which inhibit tyrosinase activity and reduce melanin biosynthesis in melanocytes. This action is realized at the cellular level through direct binding to the enzyme's active site, as well as through modulation of MITF signaling pathways. Additionally, polyphenols possess antioxidant properties, reducing reactive oxygen species levels and stabilizing membrane structures.

Ascorbic acid (vitamin C) acts as a cofactor for hydroxylases in the collagen biosynthesis process, ensuring increased skin elasticity. It also inhibits the oxidation of tetrahydrobiopterin, necessary for melanin synthesis, thereby realizing a depigmenting effect. The antioxidant activity of vitamin C is manifested in its ability to regenerate tocopherol and other antioxidants, providing a systemic influence on tissue redox status.

Chamomile extract (Chamomilla recutita) exhibits anti-inflammatory properties due to its content of apigenin, chamazulene, and α-bisabolol, which suppress cyclooxygenase-2 activity and reduce interleukin release. At the cellular level, this leads to decreased production of inflammatory mediators and restoration of skin barrier function.

Glycerin performs an osmotically active function, retains water in the stratum corneum, improves skin plasticity, and promotes restoration of the lipid barrier. Its pharmacodynamics are local in nature and aimed at prolonging the action of active substances by improving their penetration and moisture retention.

The soap base (sodium palmitate) possesses surfactant properties: removes lipid contaminants and microorganisms from the skin surface, alters stratum corneum pH, and increases the availability of active components. However, with excessive use, it can cause the opposite pharmacodynamic phenomenon — skin irritation.

Collectively, the pharmacodynamics of the preparation are characterized as local tissue-specific action on the skin, including: inhibition of melanogenesis, antioxidant effect, anti-inflammatory influence, stimulation of collagen synthesis, restoration of barrier function, and regulation of epidermal hydration. All effects are realized primarily at the cellular level (melanocytes, keratinocytes, fibroblasts) and are limited to local application without systemic impact.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley Online Library, WHO monographs.

Pharmacokinetics of Anti-Dark Spot Soap with Mulberry & Vitamin C

The pharmacokinetic characteristics of the preparation are determined by the features of its form — a solid soap for external use. Upon skin contact, absorption of active substances is limited and occurs mainly through the stratum corneum of the epidermis. Hydrophilic molecules, such as ascorbic acid, demonstrate low transdermal permeability; however, temporary increase in skin pH due to the soap base and the presence of glycerin enhance penetration by increasing hydration and permeability of the epidermal barrier.

Flavonoid compounds of Morus alba (mulberrosides, oxyresveratrol) possess lipophilic properties, allowing them to partially bind to the lipid structures of the stratum corneum, forming local depots. Their distribution is limited to superficial skin layers; systemic absorption is minimal. Upon entering the systemic circulation, metabolism occurs in the liver involving conjugation enzymes (glucuronidation, sulfation), after which metabolites are excreted primarily with bile and urine.

Chamomile flavonoids (apigenin, chamazulene, bisabolol) exhibit moderate transdermal absorption and, upon penetration, undergo intensive metabolism in the liver with the formation of glucuronide and sulfate conjugates. Excretion occurs via urine and bile.

Ascorbic acid, when applied topically, is partially deposited in the epidermis, participating in local antioxidant reactions. Amounts entering the systemic circulation are metabolized in the liver and excreted as metabolites (oxalates) through the kidneys.

Glycerin is characterized by high hydrophilicity and acts mainly locally, retaining moisture in the stratum corneum. Systemic absorption is minimal and has no clinical significance for topical application.

Thus, the pharmacokinetics of the preparation are described as predominantly local action with limited absorption of active components, their superficial distribution in the skin, and minimal systemic metabolism.

References: https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/... https://link.springer.com/arti...

Mechanisms of Action and Scientific Rationale: Anti-Dark Spot Soap with Mulberry & Vitamin C

Liver and Gastrointestinal Tract. Despite predominantly topical application, biologically active compounds of Morus alba and chamomile can influence liver enzyme systems in case of absorption. Flavonoids of the mulberroside series and apigenin can modulate the activity of phase II biotransformation enzymes, including UDP-glucuronosyltransferases and sulfotransferases, which promotes accelerated conjugation and excretion of xenobiotics. Ascorbic acid possesses membrane-stabilizing and lipotropic properties, protecting liver cells from oxidative damage and promoting regeneration of the antioxidant pool.
Reference: : https://www.sciencedirect.com/...

Nervous System. Apigenin, contained in chamomile, has affinity for GABA-A receptors, explaining its modulating sedative and anxiolytic effects with systemic use. In the context of topical application, these effects are minimal, but their contribution may be significant in the local reduction of neurogenic inflammation in the skin. Vitamin C indirectly supports the nervous system through antioxidant protection of neuronal membranes.
Reference: https://link.springer.com/arti...

Endocrine and Metabolic Regulation. Compounds of white mulberry influence glucose metabolism by inhibiting α-glucosidase and α-amylase, which has been confirmed in a number of in vitro and in vivo experiments. Although this effect is limited with topical application, the very ability of flavonoids to interact with carbohydrate metabolism enzyme systems indicates their potential with systemic absorption. Vitamin C participates in the regulation of steroidogenesis and collagen metabolism, supporting tissue-specific skin activity.
Reference: https://www.sciencedirect.com/...

Skin. The primary target of the preparation's action is the epidermis and dermis. Morus alba inhibits tyrosinase and reduces melanin synthesis; vitamin C enhances this effect and additionally stimulates collagen synthesis, providing a potentiating interaction. Chamomile reduces the activity of inflammatory mediators through suppression of NF-κB and MAPK cascades; apigenin acts at the cellular level, reducing the expression of endothelial adhesion molecules. Glycerin forms a protective layer and improves hydration, which modulates skin permeability and enhances the deposition of active substances.
Reference: https://www.ncbi.nlm.nih.gov/p...