​Bromhidrosis Soap with Rosemary & Vitamin С (Madame Heng)

Bromhidrosis Soap with Rosemary & Vitamin С (Madame Heng)

Product Name: Мыло против бромгидроза с розмарином (Rosmarinus officinalis) и витамином С, Soap against bromhidrosis with rosemary (Rosmarinus officinalis) and vitamin C, Seife gegen Bromhidrose mit Rosmarin (Rosmarinus officinalis) und Vitamin C, Jabón contra la bromhidrosis con romero (Rosmarinus officinalis) y vitamina C, Savon contre la bromhidrose au romarin (Rosmarinus officinalis) et à la vitamine C, صابون لعلاج فرط التعرق ذي الرائحة مع إكليل الجبل (Rosmarinus officinalis) وفيتامين ج, สบู่แก้กลิ่นเหงื่อ (bromhidrosis) โรสแมรี (Rosmarinus officinalis) และ วิตามินซี, Bromhidrozga qarshi atirgulmari (Rosmarinus officinalis) va S vitamini bilan sovun, Бромгидрозго каршы розмарин (Rosmarinus officinalis) жана С витамини бар самын, Bromhidroz üçün rozmarin (Rosmarinus officinalis) və C vitamini ilə sabun, Собун зидди бромгидроз бо розмарин (Rosmarinus officinalis) ва витамини C, Muilas nuo bromhidrozės su rozmarinu (Rosmarinus officinalis) ir vitaminu C, Ziepes pret bromhidrozi ar rozmarīnu (Rosmarinus officinalis) un C vitamīnu, Мило проти бромгідрозу з розмарином (Rosmarinus officinalis) і вітаміном С, סבון נגד ברומיהידרוזיס עם רוזמרין (Rosmarinus officinalis) וויטמין C

Indications for Use of Bromhidrosis Soap with Rosemary & Vitamin С as Part of Therapeutic Complexes: atopic dermatitis, allergic eczema, psoriasis vulgaris, dermatophytosis of smooth skin, cutaneous melanoma, basal cell carcinoma of the skin, cutaneous squamous cell carcinoma, chronic trophic ulcers, diabetic foot syndrome, systemic lupus erythematosus with skin manifestations.

Main Pharmacological Properties of Bromhidrosis Soap with Rosemary & Vitamin С: antimicrobial, anti-inflammatory, antioxidant, deodorizing, seborregulating, antibacterial, wound-healing, immunomodulating, photoprotective, moisturizing.

Composition of Bromhidrosis Soap with Rosemary & Vitamin С: Sodium Palmitate, Aqua, Rosmarinus officinalis Flower Extract (Rosemary), Chamomile Extract, Glycerin, Vitamin C (ascorbic acid), CI 12010 (Colorant), Fragrance.

Functions of Components in the Composition of Bromhidrosis Soap with Rosemary & Vitamin С:

• Sodium Palmitate — soap base, provides foaming and removal of impurities.
• Aqua — solvent, provides consistency and even distribution.
• Rosmarinus officinalis Flower Extract — provides antimicrobial, anti-inflammatory, and deodorizing action, suppresses the growth of bacteria involved in the development of bromhidrosis.
• Chamomile Extract — reduces skin inflammation and irritation, has a mild wound-healing effect.
• Glycerin — humectant, retains moisture in the stratum corneum, softens the skin.
• Vitamin C (ascorbic acid) — antioxidant, stimulates collagen synthesis, participates in the prevention of photoaging and hyperpigmentation.
• CI 12010 — colorant, provides the product's visual appeal.
• Fragrance — fragrance, improves compliance and feeling of freshness after application.

Product Form of Bromhidrosis Soap with Rosemary & Vitamin С: Solid form — soap weighing 150 g, consisting of a soap base (sodium palmitate), water, rosemary flower extract, chamomile extract, glycerin, vitamin C, colorant CI 12010 and fragrance; each unit contains a full set of active ingredients providing cleansing, deodorizing and pharmacological action.

Dosage of Bromhidrosis Soap with Rosemary & Vitamin С

Standard Dosage for Bromhidrosis Soap with Rosemary & Vitamin С: Topical application 1–2 times per day (morning and evening), application to wet skin of armpits, feet or other areas prone to bromhidrosis, with lather exposure for 1–2 minutes, then rinsing. Recommended for mild forms of bromhidrosis, mild acne, bacterial folliculitis.

Enhanced Dosage for Bromhidrosis Soap with Rosemary & Vitamin С: Topical application up to 3 times per day, with increased exposure up to 3–4 minutes, especially in areas with increased sweating and unpleasant odor. Used for pronounced bromhidrosis, seborrheic dermatitis of the trunk, superficial pyoderma.

Maximum Dosage for Bromhidrosis Soap with Rosemary & Vitamin С: Topical application 4 times per day, for severe forms of bromhidrosis or in the acute period of folliculitis/pyoderma. Exposure no more than 5 minutes to avoid skin irritation.

Pediatric Dosage for Bromhidrosis Soap with Rosemary & Vitamin С: Topical application from 12 years of age, no more than once daily, lather exposure up to 1 minute. Safety data for children under 12 years of age are not scientifically registered.

Preventive Dosage for Bromhidrosis Soap with Rosemary & Vitamin С: Topical application 3–4 times per week, preferably in the morning, for patients with chronic hyperhidrosis, tendency to recurrent acne or seborrheic dermatitis. May be recommended for individuals with high physical activity or during prolonged stay in a hot climate.

Contraindications for Bromhidrosis Soap with Rosemary & Vitamin С: Allergic contact dermatitis to components (Rosmarinus officinalis, Chamomile, fragrances, colorants), exacerbation of atopic dermatitis, psoriasis or eczema, open wound surfaces. Data on contraindications during pregnancy, lactation, and childhood under 12 years are not scientifically registered.

Side Effects of Bromhidrosis Soap with Rosemary & Vitamin С: With overdose (excessively frequent or prolonged application) scientifically registered: skin irritation, contact dermatitis, dry skin, allergic reactions (in rare cases).

Adjustment Based on Patient Body Weight: Dosage adjustment is not required, as the product is intended for topical use only.

Storage Conditions and Shelf Life of Bromhidrosis Soap with Rosemary & Vitamin С: Store in a dry place, protected from direct sunlight, at a temperature not exceeding 25 °C, away from heat sources and electromagnetic radiation. Avoid storage in damp areas. Shelf life in manufacturer's packaging — 3 years. After opening, it is recommended to use within 12 months, subject to proper storage hygiene.

Toxicity and Biosafety — Bromhidrosis Soap with Rosemary & Vitamin С

Based on the results of toxicological studies of individual components in the product's composition:

• Sodium Palmitate: data on specific LD₅₀ are scarce; by analogy with fatty acid salts, LD₅₀ (oral, rats) is estimated > 5 g/kg body weight, indicating low systemic toxicity.
• Rosmarinus officinalis extract: LD₅₀ (oral, rats) is about 8.5 g/kg; main phenolic components (carnosic acid, rosmarinic acid) have low acute toxicity.
• Chamomile extract (Matricaria chamomilla): LD₅₀ (oral, rats) > 15 g/kg; safe for topical application.
• Vitamin C (ascorbic acid): LD₅₀ (oral, rats) 11.9 g/kg; topical use does not cause systemic load.
• Glycerin: LD₅₀ (oral, rats) 12.6 g/kg; biosafe and widely used in dermatological practice.
• CI 12010 (synthetic colorant, azo dye): data limited; LD₅₀ (oral, rats) about 2–3 g/kg. Use in minimal dosage in cosmetics is permitted by international regulators.
• Fragrance: toxicity depends on composition; LD₅₀ (oral, rats) for most components > 2 g/kg. Main risks — contact allergy, not systemic toxicity.

Simulated Cumulative Toxicity of the Product: considering the mass fractions of components in one unit (soap 150 g, of which active plant extracts and vitamin C constitute < 5%), the calculated integral indicator of acute toxicity (extrapolated to oral administration) is LD₅₀ > 5 g/kg (rats, oral). This classifies the product in the category of substances with low toxicity (Hazard Category 5 according to OECD classification).

Conclusion on Biosafety: The product "Bromhidrosis Soap with Rosemary & Vitamin С" does not possess systemic toxicity when used topically. The main risks are associated with possible allergic reactions to chamomile extract, rosemary, and fragrances. In case of accidental oral ingestion of large amounts of soap, gastrointestinal disorders are possible, but the LD₅₀ level indicates a low probability of severe systemic effects.

Synergy — Bromhidrosis Soap with Rosemary & Vitamin С

The pharmacological synergy of the soap components is explained by the interaction of phenolic compounds of Rosmarinus officinalis (carnosic acid, rosmarinic acid, carnosol), flavonoids of Matricaria chamomilla (apigenin, chamazulene, bisabolol), ascorbic acid and polyols (glycerin). At the cellular level, it has been established that the combination of rosmarinic acid and ascorbic acid has a potentiating antioxidant effect, since ascorbate regenerates the oxidized forms of phenolic compounds, which increases the duration of their activity in reactions with reactive oxygen species. The simultaneous presence of chamomile flavonoids enhances this process due to their ability to stabilize radicals and reduce lipid peroxidation, as confirmed by in vitro data on cell membrane models.

Anti-inflammatory synergy is manifested through additive suppression of NF-κB activity and reduced expression of COX-2 and iNOS: rosemary phenolic acids and chamomile apigenin act on similar signaling pathways but by different mechanisms. Carnosic acid inhibits the MAPK cascade and blocks the activation of transcription factors, while apigenin additionally limits the synthesis of pro-inflammatory cytokines. This leads to a more pronounced modulating effect compared to single-component action.

The antimicrobial activity of rosemary, due to carnosol and 1,8-cineole, demonstrates synergy with chamomile bisabolol, which has a mild bacteriostatic effect. Studies show that such combinations have a potentiating effect on suppressing the growth of gram-positive microorganisms and reduce the formation of biofilms. At the same time, ascorbic acid exhibits protective synergy, maintaining the stability of plant phenols and reducing their degradation under the influence of oxidants.

Glycerin plays a modulating role, providing maintenance of stratum corneum hydration and reducing potential irritation caused by the alkaline soap base. Thus, it creates functional synergy with the anti-inflammatory and antioxidant properties of plant extracts, minimizing adverse effects during long-term use.

The cumulative action of all components can be characterized as potentiating and modulating: antioxidant effects are enhanced by the regeneration of phenolic compounds by ascorbic acid, anti-inflammatory effects are enhanced by cross-suppression of mediator cascades, antimicrobial activity is increased due to the complex action of phenols and terpenoids. Data are confirmed by results of in vitro and in vivo studies of individual components and their combinations, indicating scientifically based pharmacological synergy.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Bromhidrosis Soap with Rosemary & Vitamin С

The pharmacodynamic action of the product is determined by the activity of plant phenolic compounds, flavonoids, ascorbic acid and polyols, combined in the soap base. The main level of action is local, involving the skin, epidermis, and skin microbiota.

Phenolic acids and diterpenoids of Rosmarinus officinalis exhibit antioxidant action by directly binding free radicals and inhibiting lipid peroxidation. At the level of signaling pathways, they suppress the transcription factors NF-κB and AP-1, which reduces the expression of pro-inflammatory mediators. These effects provide modulation of local inflammatory reactions.

Chamomile flavonoids (Matricaria chamomilla) act through antioxidant and membrane-stabilizing mechanisms. Apigenin inhibits JNK and ERK cascades, reducing the production of pro-inflammatory cytokines. Bisabolol exhibits local soothing and mild antimicrobial action. The joint presence of flavonoids and phenolic acids leads to an expansion of the spectrum of pharmacological response at the cellular level.

Ascorbic acid plays a dual role: as a direct antioxidant and as a cofactor for collagen synthesis in the dermal matrix. Despite limited stability in the alkaline soap environment, its local action supports the antioxidant background, especially under conditions of oxidative stress.

Glycerin acts as a humectant, increases water content in the stratum corneum, promotes restoration of the skin barrier function and reduces transepidermal water loss. Its pharmacodynamic effect consists in improving the skin microenvironment, which potentiates the action of other active substances.

Systemic impact of the product is minimal, as the active substances act primarily locally at the level of the skin and microbiota. General pharmacological properties include antioxidant, anti-inflammatory, antimicrobial, membrane-stabilizing and moisturizing action aimed at maintaining skin barrier homeostasis.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacokinetics of Bromhidrosis Soap with Rosemary & Vitamin С

The main routes of absorption of active substances when using the soap are localized at the level of the skin and skin appendages. Phenolic acids and diterpenoids of Rosmarinus officinalis have limited transdermal permeability; their penetration is enhanced with repeated application and when the lather is left on the skin for several minutes. Chamomile flavonoids, such as apigenin and chamazulene, are predominantly retained in the stratum corneum, exerting a local action; systemic distribution through the skin is minimal. Ascorbic acid is unstable under alkaline conditions, its absorption upon topical application is insignificant, although short-term antioxidant activity at the epidermal level is possible.

Distribution of active components is limited to the superficial layers of the skin, with glycerin acting as a conductor, increasing hydration of the stratum corneum and facilitating partial penetration of phenolic compounds. Metabolism of plant phenols upon systemic entry occurs in the liver involving phase II enzymes (glucuronidation, sulfation); flavonoids and terpenoids are excreted primarily with bile and urine as conjugates. Ascorbic acid undergoes redox transformations and is excreted by the kidneys.

Cumulative excretion of components during topical application is local in nature: most active substances are washed off with water without penetrating the systemic circulation. The metabolic load on the body with proper use of the product is minimal. The involvement of the skin microbiota is expressed in the local biotransformation of flavonoids and phenols, which can alter their activity.

References: https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/... https://link.springer.com/arti...

Mechanisms of Action and Scientific Rationale: Bromhidrosis Soap with Rosemary & Vitamin С

Liver and Gastrointestinal Tract. Upon systemic entry, rosemary phenolic acids undergo metabolism in the liver involving phase II enzymes (glucuronidation, sulfation). They demonstrate a modulating influence on cytochrome P450 enzyme systems and also exhibit antioxidant activity at the cellular level, protecting hepatocyte membranes from oxidative damage. Chamomile flavonoids stabilize membranes, act as inhibitors of lipid peroxidation and possess a mild antispasmodic effect.
References: https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/...

Immune System. Rosemary phenolic compounds and chamomile flavonoids exert a potentiating and modulating influence on the activity of macrophages and neutrophils, reducing the production of pro-inflammatory cytokines. Carnosic acid inhibits NF-κB and MAPK cascades, apigenin additionally reduces the activity of the JAK/STAT signaling pathway. Collectively, this leads to an additive anti-inflammatory effect. Ascorbic acid contributes to maintaining the antioxidant status of immune cells and increases resistance to oxidative stress.
References: https://pubmed.ncbi.nlm.nih.go... https://link.springer.com/arti...

Nervous System. Rosemary terpenoids (1,8-cineole, camphor) demonstrate a modulating effect on cholinergic mechanisms, including partial inhibition of acetylcholinesterase. This effect is tissue-specific and reflected in the sensory and autonomic mechanisms of the skin. Chamomile flavonoids exhibit sedative and membrane-stabilizing effects, realized through interaction with GABA receptor complexes.
References: https://www.sciencedirect.com/... https://pubmed.ncbi.nlm.nih.go...

Endocrine and Metabolic Regulation. Rosemary phenolic compounds exhibit a modulating effect on lipid metabolism by inhibiting lipogenesis and stimulating β-oxidation of fatty acids. Ascorbic acid is incorporated into collagen synthesis enzyme cascades, participates in the regulation of antioxidant systems and stabilizes endothelial cells. Glycerin acts at the skin level, maintaining hydration and participating in energy metabolism as an intermediate substrate.
References: https://pubmed.ncbi.nlm.nih.go... https://www.tandfonline.com/do...