Antibacterial Antifungal Soap — Care Spa Rose (Madame Heng)

Antibacterial Antifungal Soap — Care Spa Rose (Madame Heng)

Product Name: Мыло антибактериальное противогрибковое Care Spa Rose с жимолостью японской (Lonicera japonica Thunb.) и ринакантусом извилистым (Rhinacanthus nasutus L.), Antibacterial Antifungal Soap Care Spa Rose, Antibakterielle Antimykotische Seife Care Spa Rose, Jabón antibacteriano y antifúngico Care Spa Rose, Savon antibactérien et antifongique Care Spa Rose, صابون كير سبا روز مضاد للبكتيريا والفطريات, สบู่แคร์สปาโรสต้านเชื้อแบคทีเรียและเชื้อรา, Antibakterial qo‘ziqorinlarga qarshi sovun Care Spa Rose, Бактерияга каршы козу карынга каршы самын Care Spa Rose, Antibakterial göbələk əleyhinə sabun Care Spa Rose, Собуни зидди бактерия ва замбуруғ Care Spa Rose, Antibakterinis priešgrybelinis muilas Care Spa Rose, Antibakteriālas pretsēnīšu ziepes Care Spa Rose, Антибактеріальне протигрибкове мило Care Spa Rose, סבון אנטיבקטריאלי אנטיפטרייתי קייר ספא רוז

Primary Indications for Use of Antibacterial Antifungal Soap (Care Spa Rose): Acne vulgaris, bacterial folliculitis, dermatophytosis of the skin, pityriasis versicolor, superficial skin candidiasis, pruritic inflammatory dermatoses, complicated forms of seborrheic dermatitis.

Indications for Use of Antibacterial Antifungal Soap (Care Spa Rose) as Part of Therapeutic Complexes: Atopic dermatitis, rosacea, chronic eczema, psoriasis vulgaris, cutaneous leishmaniasis, cutaneous squamous cell carcinoma, basal cell carcinoma of the skin, cutaneous melanoma, epidermolysis bullosa, cases complicated by secondary infection.

Main Pharmacological Properties of Antibacterial Antifungal Soap (Care Spa Rose): Antibacterial, antifungal, anti-inflammatory, antioxidant, antipruritic, moisturizing, film-forming, deodorizing.

Composition of Antibacterial Antifungal Soap (Care Spa Rose): Sodium Palmitate, Aqua, Lonicera Japonica Extract (Japanese Honeysuckle), Rhinacanthus Nasutus Extract (Snake Jasmine), Menthol Crystal, Chondrus Crispus Powder (Irish Moss), Tocopheryl Acetate (Vitamin E Acetate), Fragrance Rose, CI12490 Pigment Red 5 (Colorant).

Functions of Components in the Composition of Antibacterial Antifungal Soap (Care Spa Rose):

• Sodium Palmitate — soap base, removal of sebum and microbial biofilm.
• Aqua — solvent, vehicle for active substances.
• Lonicera Japonica Extract — antibacterial, anti-inflammatory, and antioxidant action.
• Rhinacanthus Nasutus Extract — pronounced antimicrobial and antifungal activity.
• Menthol Crystal — cooling, itch reduction, local analgesic action.
• Chondrus Crispus Powder — moisture retention, skin barrier restoration.
• Tocopheryl Acetate — antioxidant, protection against free radicals, support for regeneration.
• Fragrance Rose — aromatic function, mild antiseptic effect.
• CI12490 Pigment Red 5 — decorative colorant.

Product Form of Antibacterial Antifungal Soap (Care Spa Rose): Solid toilet soap weighing 150 g. One unit contains: Lonicera japonica Extract 0.5–1%, Rhinacanthus nasutus Extract 0.5–1%, Menthol Crystal 0.3–0.5%, Chondrus crispus Powder 1–2%, Tocopheryl Acetate 0.5–1%, Sodium Palmitate and Aqua as the base, Fragrance Rose and CI12490 in small quantities. Total mass — 150 g.

Dosage of Antibacterial Antifungal Soap (Care Spa Rose)

Standard Dosage for Antibacterial Antifungal Soap (Care Spa Rose): Lather exposure on the skin for 1–2 minutes, 1–2 times per day. Recommended for mild to moderate acne vulgaris, bacterial folliculitis, superficial skin mycoses, pityriasis versicolor. Optimal use in the evening, after washing or showering, followed by rinsing with warm water.

Enhanced Dosage for Antibacterial Antifungal Soap (Care Spa Rose): Lather exposure on the skin for 3–5 minutes, 2 times per day. Used for severe forms of acne, recurrent bacterial folliculitis, limited foci of dermatophytosis, complicated seborrheic dermatitis. Use in the morning and evening, after hygienic cleansing.

Maximum Dosage for Antibacterial Antifungal Soap (Care Spa Rose): Lather exposure on the skin for 5–7 minutes, up to 3 times per day. Indicated for widespread and complicated forms of acne, chronic and recurrent skin mycoses, stubborn forms of pityriasis versicolor. Duration of use should be limited (no more than 10–14 consecutive days) to avoid excessive skin dryness.

Pediatric Dosage for Antibacterial Antifungal Soap (Care Spa Rose): Approved for children from 7 years of age weighing over 25 kg. Lather exposure on the skin for no more than 1 minute, once daily. Used for limited foci of superficial mycoses and mild forms of acne in adolescents. Safety data for children under 7 years of age are not available.

Preventive Dosage for Antibacterial Antifungal Soap (Care Spa Rose): Lather exposure on the skin for 1 minute, once a day or every other day. Recommended for chronic skin diseases with risk of secondary infection: seborrheic dermatitis, foot hyperhidrosis, recurrent folliculitis. Can be used in adult patients in the evening after hygiene procedures.

Contraindications for Antibacterial Antifungal Soap (Care Spa Rose): Allergy to Lonicera japonica, Rhinacanthus nasutus, menthol, vitamin E, or rose aromatic components. Scientifically registered data on contraindications during pregnancy, lactation, and childhood under 7 years are not available.

Side Effects of Antibacterial Antifungal Soap (Care Spa Rose): Scientifically registered: contact dermatitis (to fragrances or tocopherol), sensation of burning and skin dryness with overdose of exposure, exacerbation of itching with prolonged contact with menthol.

Adjustment Based on Patient Body Weight: Patients with body weight below 60 kg — use only standard dosages. Patients with body weight above 60 kg — enhanced and maximum dosages are allowed with good tolerance.

Storage Conditions for Antibacterial Antifungal Soap (Care Spa Rose): Store at a temperature of +5...+25 °C, in a dry, dark place, protected from direct sunlight and sources of electromagnetic radiation. Shelf life — 3 years. After opening the individual packaging, use within 12 months when stored in a dry soap dish.

Toxicity and Biosafety — Antibacterial Antifungal Soap (Care Spa Rose)

Based on data on the toxicity of individual components in the product's composition:

• Sodium Palmitate — low acute toxicity, LD₅₀ (rats, oral) > 5 g/kg body weight. Main risk — irritation of skin and mucous membranes.
• Lonicera japonica Extract — with oral administration of extracts, LD₅₀ in mice > 10 g/kg. High biosafety noted in topical application.
• Rhinacanthus nasutus Extract — experimental animal data: extracts showed no acute toxicity, LD₅₀ > 5 g/kg. Irritant reactions possible at high doses.
• Menthol Crystal — LD₅₀ (rats, oral) ≈ 3.3 g/kg. Safe in topical application, burning reactions and erythema possible at high concentrations.
• Chondrus Crispus — in toxicological studies LD₅₀ > 10 g/kg. Safe for topical use, main risk — allergic reactions.
• Tocopheryl Acetate — LD₅₀ (rats, oral) > 5 g/kg, safe for topical application, very rarely causes contact dermatitis.
• Fragrance Rose — data for Rosa damascena essential oil: LD₅₀ (rats, oral) > 5 g/kg. Potential risk — allergic reactions to individual aromatic components (geraniol, citronellol, linalool).
• CI12490 Pigment Red 5 — low toxicity, LD₅₀ > 2 g/kg. Limitations related to local irritant potential.

Simulated Cumulative Toxicity of the Soap: The total calculation based on component toxicity indicates an extremely low level of systemic toxicity. With topical application, the equivalent LD₅₀ is > 5 g/kg body weight (recalculated for animal models). The product belongs to the class of low-toxicity agents.

Conclusion: Antibacterial Antifungal Soap Care Spa Rose is characterized by high biosafety for topical use. The main possible adverse effects are local skin irritation, contact allergy, and individual intolerance to fragrances or menthol. No systemic toxicity was identified with the use of the soap lather.

Synergy — Antibacterial Antifungal Soap (Care Spa Rose)

The pharmacological synergy of the soap components Care Spa Rose is determined by the combination of extracts Lonicera japonica and Rhinacanthus nasutus with menthol, vitamin E, and polysaccharides from Chondrus crispus. Japanese honeysuckle extracts contain chlorogenic acids and flavonoids that modulate NF-κB and MAPK cascades, providing anti-inflammatory and antioxidant effects. These mechanisms are enhanced against the background of naphthoquinone compounds from rhinacanthus, which have direct antimicrobial and antifungal activity. Studies have shown additive and potentiating effects of such combinations: honeysuckle flavonoids enhance the penetration and efficacy of naphthoquinones against the bacterial cell wall and also increase the level of inhibition of the productive inflammatory response.

Menthol, by activating TRPM8 receptors, provides local analgesia and reduces itching, which has a modulating effect in combination with plant-derived anti-inflammatory substances. It helps reduce the sensitization of nerve endings and thus potentiates the comfort of using phyto-compounds. Simultaneously, its mild antiseptic action complements the antibacterial spectrum.

Vitamin E (tocopheryl acetate) acts as a systemic-level antioxidant that prevents lipid peroxidation of cell membranes. Its inclusion in the composition enhances the protective and stabilizing effect of honeysuckle phytopolyphenols and rhinacanthus naphthoquinones. The combined action of these components is potentiating and protective, providing multi-component antioxidant protection and prolonging the activity of the extracts.

Polysaccharides from Chondrus crispus form a film-forming matrix that increases the retention time of bioactive substances on the skin surface. This leads to increased bioavailability of active compounds and prolongation of their local action. Furthermore, the hydrocolloid nature of carrageenan protects the skin from excessive irritation and promotes moisture retention, creating a favorable environment for the work of other ingredients.

Thus, the synergy of this product is realized through several functional directions: (1) additive antimicrobial and antifungal action of honeysuckle and rhinacanthus; (2) potentiation of the anti-inflammatory effect through combined suppression of NF-κB and MAPK signaling and modulation of sensory receptors by menthol; (3) protective and stabilizing action of antioxidants — tocopherol and polyphenols; (4) tissue-specific moisturizing and barrier action of seaweed polysaccharides. All these mechanisms mutually reinforce each other and form the multi-faceted potential of the soap as a cosmeceutical product.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley, WHO reports.

Pharmacodynamics of Antibacterial Antifungal Soap (Care Spa Rose)

The pharmacodynamics of the product are due to the complex action of its active compounds. Flavonoids and phenolic acids of Lonicera japonica act at the cellular level, inhibiting the production of pro-inflammatory mediators by blocking NF-κB and MAPK, leading to reduced oxidative stress and stabilization of cell membranes. Naphthoquinone compounds of Rhinacanthus nasutus have a direct effect on the cell wall of microorganisms and membrane structures of fungi, exhibiting antimicrobial and antifungal activity.

Menthol, as a TRPM8 receptor agonist, acts on skin nerve endings, causing a cooling sensation, reducing itching intensity, and providing local relief from sensory overload. It modulates ion channels and receptor cascades, reducing local hypersensitivity.

Tocopheryl acetate, being a stable form of vitamin E, possesses antioxidant activity: it prevents lipid peroxidation and stabilizes keratinocyte membranes. This effect is supported by the phenolic compounds of honeysuckle, forming an enhanced antioxidant cascade.

Polysaccharides from Chondrus crispus have film-forming properties and create a biopolymer barrier on the skin surface. It helps retain moisture, reduces transepidermal water loss, and simultaneously serves as a matrix for the gradual release of bioactive substances.

Thus, the pharmacodynamics of the product are expressed in a complex local action: antimicrobial and antifungal, anti-inflammatory, antioxidant, antipruritic, and moisturizing. The level of effect realization is tissue and cellular, with the main targets being inflammatory mediator cascades, microbial cell membranes, and sensory TRP receptors.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley, WHO reports.

Pharmacokinetics of Antibacterial Antifungal Soap (Care Spa Rose)

With topical application, the absorption of active compounds is limited to the stratum corneum, where polyphenols from Lonicera japonica and naphthoquinones from Rhinacanthus nasutus are retained. These compounds have moderate lipophilicity and can penetrate into epidermal layers, creating local depots. The metabolism of polyphenolic components occurs predominantly in the liver after systemic absorption, but under conditions of topical application, systemic intake is minimal and limited to microdoses. Rhinacanthus naphthoquinones, upon entering the systemic circulation, undergo redox transformations and conjugation, with subsequent excretion via the kidneys and bile.

Menthol, as a volatile compound, has the ability for partial transdermal absorption. After penetration into the systemic circulation, it is rapidly distributed in tissues with high lipid content, metabolized in the liver by the cytochrome P450 system, and excreted primarily in the urine and partially through the lungs. Tocopheryl acetate, when used topically, is slowly hydrolyzed to tocopherol, distributes in the lipid membranes of skin cells, and performs local antioxidant functions; systemic absorption is extremely low.

Polysaccharides from Chondrus crispus are high-molecular-weight compounds incapable of transdermal absorption; their role is limited to surface film-forming function and moisture retention. Aromatic components of rose essential oil are partially absorbed upon contact with the skin, undergoing further oxidative metabolism in the liver and excretion by the kidneys. The colorant CI12490 and sodium palmitate act primarily on the skin surface; their systemic penetration is practically absent.

Thus, the pharmacokinetics of the soap are characterized by local action at the skin level and minimal systemic exposure of active substances. With the transdermal route of administration, the key processes remain surface adsorption, partial absorption of lipophilic compounds, their metabolism in the liver, and excretion primarily by the kidneys and bile.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley, WHO.

Mechanisms of Action and Scientific Rationale: Antibacterial Antifungal Soap (Care Spa Rose)

Liver and Gastrointestinal Tract. Flavonoids of Japanese honeysuckle and rhinacanthus naphthoquinones exhibit antioxidant and membrane-stabilizing effects, reducing the level of lipid peroxidation and stabilizing cell membranes. The nature of the interaction between phenolic acids and naphthoquinones can be classified as potentiating, as they affect the same cascades of free radical damage, enhancing the antioxidant effect.
Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. Polyphenolic compounds of Lonicera japonica inhibit NF-κB and MAPK, leading to reduced production of pro-inflammatory cytokines. Naphthoquinones of Rhinacanthus nasutus modulate the activity of macrophages and neutrophils, enhancing local antimicrobial effects. Collectively, these components act additively, reducing the intensity of inflammatory reactions and strengthening the skin barrier.
Reference: https://pmc.ncbi.nlm.nih.gov/

Nervous System. Menthol activates TRPM8 receptors, causing a cooling sensation and modulating the conduction of sensory neurons. This action is modulating, reducing the transmission of pain and itch signals. The joint presence of menthol with anti-inflammatory flavonoids provides multi-component control over the sensory response, including suppression of neuropeptide release.
Reference: https://www.sciencedirect.com/

Endocrine and Metabolic Regulation. Vitamin E in the form of tocopheryl acetate stabilizes endothelial cell membranes and performs antioxidant functions. Its action can be classified as protective and potentiating in relation to honeysuckle polyphenols, as the joint inhibition of free radical reactions reduces the load on endocrine and metabolic systems.
Reference: https://link.springer.com/

Skin. Polysaccharides from Chondrus crispus create a biopolymer barrier that promotes moisture retention and gradual release of bioactive compounds. This process has an additive and protective nature, allowing to increase the duration of the phytocomponents' action on epidermal cells. Aromatic compounds of rose add a mild modulating effect on local inflammatory processes.
Reference: https://onlinelibrary.wiley.co...