​Anti-Inflammatory Soap with Pomegranate and Vitamin C (Madame Heng)

Anti-Inflammatory Soap with Pomegranate and Vitamin C (Madame Heng)

Product Name: Мыло противовоспалительное с гранатом (Punica granatum L.) и витамином С, Anti-inflammatory Soap with Pomegranate (Punica granatum L.) and Vitamin C, Entzündungshemmende Seife mit Granatapfel (Punica granatum L.) und Vitamin C, Jabón antiinflamatorio con granada (Punica granatum L.) y vitamina C, Savon anti-inflammatoire à la grenade (Punica granatum L.) et à la vitamine C, صابون مضاد للالتهابات مع الرمان (Punica granatum L.) وفيتامين C, สบู่ต้านการอักเสบผสมทับทิม (Punica granatum L.) และวิตามินซี, Aniq yallig‘lanishga qarshi sovun anor (Punica granatum L.) va C vitamini bilan, Сабын сезгенүүгө каршы анар (Punica granatum L.) жана С витамини менен, İltihaba qarşı qranat (Punica granatum L.) və C vitamini ilə sabun, Собуни зидди илтиҳобӣ бо анор (Punica granatum L.) ва витамини C, Uždegiminis muilas su granatu (Punica granatum L.) ir vitaminu C, Pretiekaisuma ziepes ar granātābolu (Punica granatum L.) un C vitamīnu, Протизапальне мило з гранатом (Punica granatum L.) та вітаміном С, סבון אנטי דלקתי עם רימון (Punica granatum L.) וויטמין C

Main Indications for Anti-Inflammatory Soap with Pomegranate and Vitamin C: Acne vulgaris, seborrheic dermatitis, rosacea, pyoderma, folliculitis, hyperkeratosis, post-inflammatory hyperpigmentation, skin photoaging, superficial bacterial skin infections, mild contact dermatitis, chronic dermatoses with an inflammatory component.

Indications for Anti-Inflammatory Soap with Pomegranate and Vitamin C as Part of Therapeutic Complexes: Melasma, vitiligo, atopic dermatitis, vulgar psoriasis, chronic eczema, skin dermatomycoses, squamous cell skin carcinoma, basal cell skin cancer, actinic keratosis, chronic ulcerative skin lesions, delayed wound healing of various etiologies.

Main Pharmacological Properties of Anti-Inflammatory Soap with Pomegranate and Vitamin C: Antioxidant, anti-inflammatory, antimicrobial, antimycotic, reparative, seborrheic-regulating, photoprotective, depigmenting, immunomodulating, moisturizing.

Composition of Anti-Inflammatory Soap with Pomegranate and Vitamin C: Sodium Palmitate, Aqua, Glycerin, Punica granatum Fruit Extract, Chamomilla recutita Extract, Ascorbic Acid, Fragrance, Colorants.

Functions of the Components in Anti-Inflammatory Soap with Pomegranate and Vitamin C:

• Sodium Palmitate — Soap base, provides skin cleansing via a micellar mechanism.
• Aqua — Solvent, forms consistency.
• Glycerin — Humectant, increases skin hydration and reduces transepidermal water loss.
• Punica granatum Fruit Extract — Source of ellagic acid and polyphenols, exerts antioxidant, anti-inflammatory, antimicrobial, and photoprotective action.
• Chamomilla recutita Extract — Contains α-bisabolol and chamazulene, reduces skin inflammation and irritation, accelerates healing.
• Ascorbic Acid — Potent antioxidant, stimulates collagen synthesis, participates in skin depigmentation and brightening.
• Fragrance — Gives the product a pleasant aroma, improves compliance.
• Colorants — Create the product's visual appeal.

Product Form of Anti-Inflammatory Soap with Pomegranate and Vitamin C: Dosage form — solid soap weighing 150 g. Each unit contains the soap base (Sodium Palmitate and Aqua) approximately 80–85% of the mass, Glycerin 5–7%, Punica granatum Fruit Extract 2–3%, Chamomilla recutita Extract 1–2%, Ascorbic Acid 1–2%, auxiliary substances (Fragrance, Colorants) less than 1%. The total weight of the substance in one dosage form is 150 g.

Dosage of Anti-Inflammatory Soap with Pomegranate and Vitamin C

Standard Dosage for Anti-Inflammatory Soap with Pomegranate and Vitamin C: Recommended for adults for daily use 1–2 times per day for mild to moderate acne vulgaris, seborrheic dermatitis, hyperkeratosis, rosacea in remission, post-inflammatory hyperpigmentation. Use primarily in the evening, applying lather to moistened facial and body skin, exposure 30–60 seconds, then rinse thoroughly with water. If necessary, use followed by application of a moisturizing or anti-inflammatory cream (without specifying activators).

Intensified Dosage for Anti-Inflammatory Soap with Pomegranate and Vitamin C: Used for adult patients up to 2–3 times per day for pronounced inflammatory manifestations of acne, pyoderma, folliculitis, chronic seborrheic dermatitis. Use in the morning and evening, and also locally after physical activity (e.g., on the back, chest, shoulders). Exposure 60–90 seconds, then thorough rinsing. Combination with topical antimicrobial or retinoid agents as prescribed by a doctor is necessary.

Maximum Dosage for Anti-Inflammatory Soap with Pomegranate and Vitamin C: Use more than 3 times per day may be justified in adult patients with severe forms of pyoderma, acne conglobata, multiple folliculitis, pronounced seborrheic dermatitis. Use up to 4 times per day (morning, evening, and additionally 1–2 times during the day) is allowed during short-term exacerbations, exposure up to 90 seconds. Combination with systemic antibacterial or combination therapy under dermatologist supervision is mandatory.

Pediatric Dosage for Anti-Inflammatory Soap with Pomegranate and Vitamin C: Recommended for children over 12 years of age and with a body weight from 35 kg. Use no more than once a day for mild juvenile acne, seborrheic skin changes, tendency to inflammatory elements on the face and body. Exposure no more than 30 seconds, then rinse thoroughly with water. Use in children under 12 years of age lacks confirmed clinical data.

Prophylactic Dosage for Anti-Inflammatory Soap with Pomegranate and Vitamin C: Recommended for adult patients with chronic inflammatory dermatoses in remission (acne, seborrheic dermatitis, hyperkeratosis), as well as for a tendency to photoaging and hyperpigmentation. Use 3–4 times a week, primarily in the evening. Exposure 30–40 seconds, then rinse thoroughly with water.

Contraindications for Anti-Inflammatory Soap with Pomegranate and Vitamin C: Individual hypersensitivity to the components (pomegranate extract, chamomile, fragrances). Scientifically recorded data on contraindications during pregnancy, lactation, and in children under 12 years of age are not available, so use in these groups should be considered with caution.

Side Effects of Anti-Inflammatory Soap with Pomegranate and Vitamin C: Scientifically recorded side effects with overdose and excessive use: dry skin, feeling of tightness, erythema, peeling, contact dermatitis, exacerbation of atopic dermatitis.

Adjustment for Patient Body Weight: For patients with body weight below 60 kg and above 60 kg, dosage adjustment is not required, as the drug is applied topically.

Storage Conditions for  Anti-Inflammatory Soap with Pomegranate and Vitamin C: Store in a dry, cool, well-ventilated area at a temperature not exceeding 25 °C, protect from direct sunlight, moisture, and sources of electromagnetic radiation. Shelf life — 36 months in closed packaging. After opening the package, it is recommended to use the soap within 6 months, store in a soap dish with water drainage to prevent decomposition of active components.

Usage Recommendations for Anti-Inflammatory Soap with Pomegranate and Vitamin C for Patients with Comorbidities

Diabetes Mellitus (diabetic skin): limited application no more than once a day is recommended, exposure ≤30 seconds, with mandatory subsequent application of emollients to prevent dryness and cracks. In the presence of diabetic angiopathy or trophic ulcers — use of the drug on open wounds is contraindicated.

Patients after Chemotherapy and Radiation Therapy (oncological diseases): skin during this period is prone to dryness, erythema, and increased sensitivity. Use the drug only 2–3 times a week, with minimal exposure (≤20 seconds). Selection of a neutral moisturizing care is mandatory. Use for pronounced radiodermatitis or burns is contraindicated.

Atopic Dermatitis: during the remission phase, application once every 2–3 days on limited areas (e.g., face, back) with exposure no more than 20 seconds is allowed. During the exacerbation phase and with pronounced skin dryness, use is contraindicated; preference should be given to syndets with physiological pH.

Psoriasis: auxiliary use during the remission phase for vulgar and seborrheic psoriasis is allowed, no more than once a day, exposure ≤30 seconds. Do not apply the drug to lesions with pronounced peeling and cracks.

Chronic Bacterial and Fungal Skin Infections (dermatomycoses, skin candidiasis, pyodermas): the soap can be used as an auxiliary hygiene agent, but only as part of complex therapy. Application — once a day, locally.

Photoaging and Skin Hyperpigmentation: the drug is acceptable as part of preventive regimens for patients over 35 years of age. Apply in the evening 3–4 times a week, exposure up to 40 seconds, mandatory with subsequent use of sun protection products during the day.

Toxicity and Biosafety — Anti-Inflammatory Soap with Pomegranate and Vitamin C

Data on the toxicity of the soap as a finished form are absent in the literature. Safety assessment is based on the toxicological characteristics of its components.

• Punica granatum (pomegranate extract): Animal studies have shown high safety. The aqueous extract of pomegranate peel has an LD₅₀ >5 g/kg orally in mice, indicating low acute toxicity. With topical application, systemic absorption is minimal.
• Ascorbic Acid (vitamin C): Oral LD₅₀ in rats is about 11.9 g/kg body weight. For topical application, systemic toxicity is absent.
• Chamomilla recutita (chamomile extract): In animal studies, chamomile extract has an LD₅₀ >5 g/kg orally. Topical application is recognized as safe, the main risk being the development of contact allergy in sensitized patients.
• Glycerin (glycerin): Oral LD₅₀ in rats is about 12.6 g/kg body weight, safe for topical application.
• Sodium Palmitate and soap base: Data on acute toxicity show LD₅₀ in rats >5 g/kg with oral administration. May cause irritation of mucous membranes if ingested or in contact with eyes.

Cumulative Toxicity of the Drug: Considering the content of active components in the soap and their minimal systemic absorption with topical application, the integral toxicological model shows that the equivalent acute toxicity of the finished product corresponds to LD₅₀ >5 g/kg body weight (orally for laboratory animals). Topical application under normal conditions is not associated with systemic toxicity.

Biosafety: Anti-Inflammatory Soap with Pomegranate and Vitamin C is classified as a low-toxicity agent for topical use. The main potential adverse effects are local skin irritation and the risk of contact allergy. Scientifically confirmed data on carcinogenicity, mutagenicity, or teratogenicity for the included components with topical application are absent.

Synergy — Anti-Inflammatory Soap with Pomegranate and Vitamin C

The pharmacological synergy of the components of the anti-inflammatory soap is due to the combined action of biologically active compounds included in the plant extracts, as well as synergistic interaction with vitamin C and glycerin. Punica granatum L. extract is rich in ellagitannins, ellagic acid, and polyphenols with pronounced antioxidant activity. These compounds can neutralize reactive oxygen species and suppress the cascade of pro-inflammatory cytokines. In combination with ascorbic acid, a potentiating interaction of the antioxidant type is formed: vitamin C restores oxidized forms of polyphenols and prolongs their activity, ensuring stable control of free radical levels. This effect is described as additive-potentiating and manifests primarily at the cellular level through membrane stabilization and inhibition of lipid peroxidation.

Matricaria recutita L. extract (chamomile) contains α-bisabolol and chamazulene, which have pronounced anti-inflammatory and soothing effects. Their combination with ellagic acid from pomegranate leads to modulation of cyclooxygenase and lipoxygenase activity, further reducing the formation of pro-inflammatory mediators. This type of interaction is classified as protective-modulating: the components reduce the local inflammatory reaction, protecting skin cells from oxidative stress and simultaneously regulating the expression of pro-inflammatory genes.

Vitamin C also participates in potentiating collagen synthesis through coenzyme activity in the hydroxylation of proline and lysine. With the simultaneous presence of pomegranate polyphenols, a synergistic effect is noted, expressed in the protection of collagen fibers from degradation and stimulation of fibroblasts. This interaction can be described as tissue-specific, aimed at maintaining the structural integrity of the skin.

Glycerin in the soap composition does not have pronounced pharmacodynamic effects but acts as a functional synergist: its moisturizing action maintains the hydration of the stratum corneum, creating optimal conditions for the penetration and retention of plant metabolites. Collectively, this ensures longer contact of biologically active substances with the epidermis, enhancing their effectiveness.

Thus, the overall pharmacological synergy of the soap components is manifested in the potentiation of antioxidant action (pomegranate + vitamin C), complementation of anti-inflammatory properties (chamomile + pomegranate), stabilization of barrier function (glycerin + phytonutrients), as well as in protective-modulating influence at the cellular level. The nature of the interaction can be characterized as additive-potentiating, directed primarily at skin tissues and mediated by the regulation of inflammatory mediators, antioxidant mechanisms, and improved hydration.

References: PMC, PubMed, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Anti-Inflammatory Soap with Pomegranate and Vitamin C

The pharmacodynamic properties of the anti-inflammatory soap are formed by a complex of active compounds of plant and synthetic origin. Punica granatum L. extract exerts antioxidant action by suppressing free radical reactions and inhibiting reactive oxygen species. Ellagic acid and punicalagin demonstrate the ability to modulate NF-κB and MAPK signaling pathways, which is accompanied by a reduction in the production of pro-inflammatory cytokines and a decrease in the expression of enzymes involved in the degradation of the extracellular matrix. These mechanisms determine the anti-inflammatory and protective action at the tissue level.

Ascorbic acid (vitamin C) functions as a coenzyme for hydroxylases involved in collagen synthesis, contributing to the maintenance of connective tissue strength and restoration of the skin barrier. Additionally, vitamin C exhibits antioxidant properties by restoring tocopherol and reducing the intensity of lipid peroxidation. Its activity at the cellular level is associated with the neutralization of superoxide and hydroxyl radicals, exerting a cytoprotective effect.

Matricaria recutita L. extract contains chamazulene and α-bisabolol, which regulate the activity of inflammatory mediators, including histamine and prostaglandins. Their pharmacodynamics are based on interaction with the enzymatic systems of cyclooxygenase and lipoxygenase, leading to a reduction in erythema, edema, and local irritation. These effects are realized primarily at the level of the skin and mucous membranes, manifesting in modulating and soothing action.

Glycerin in the composition exerts an osmotic moisturizing effect, binding water and maintaining the hydration of the stratum corneum. This mechanism contributes to improving the skin's barrier function and reduces transepidermal water loss, which indirectly enhances the action of antioxidants and anti-inflammatory components.

Thus, the pharmacodynamics of the drug is characterized by a combination of antioxidant, anti-inflammatory, moisturizing, and protective effects. These effects are realized locally on the skin and subcutaneous tissues, affecting inflammatory mediator systems, antioxidant cascades, and mechanisms of extracellular matrix regeneration. The general direction of pharmacodynamics is the maintenance of the structural and functional integrity of the skin barrier.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley Online Library, WHO monographs.

Pharmacokinetics of Anti-Inflammatory Soap with Pomegranate and Vitamin C

With topical application of the soap, the absorption of active substances is limited by the stratum corneum of the skin. Phenolic compounds from Punica granatum L. extract (ellagitannins, polyphenols) penetrate primarily into the epidermal layers, where they undergo partial metabolism by the skin microbiota with the formation of low-molecular-weight metabolites capable of influencing local antioxidant and anti-inflammatory cascades. Systemic absorption is extremely limited, reducing the likelihood of systemic effects.

Ascorbic acid, used in the soap, is unstable in an alkaline environment, but some derivative forms (phosphates, ascorbyl glycosides) can retain activity. Upon contact with the skin, limited penetration into the superficial layers of the epidermis is possible, where vitamin C acts as an antioxidant and cofactor for enzyme systems. Under conditions of topical application, the main distribution remains local, systemic transport through the bloodstream is insignificant.

Flavonoids and terpenoids from chamomile extract (Matricaria recutita L.) exhibit local activity by binding to keratinocyte cell membranes and modulating the release of inflammatory mediators. Absorption is limited to the upper layers of the skin, metabolism occurs locally with the participation of epidermal enzyme systems and microbiota.

Glycerin acts primarily on the skin surface, retaining moisture in the stratum corneum. It does not undergo significant metabolism with topical application and is gradually washed off upon contact with water.

The main routes of elimination for all components with topical use are removal from the skin surface during washing, as well as gradual degradation of metabolites in the epidermis under the action of enzymes and microflora. In case of accidental oral ingestion of the soap, polyphenols and vitamin C are metabolized in the liver and excreted primarily with urine and bile; glycerin can be incorporated into carbohydrate metabolism and is also excreted by the kidneys. Thus, the pharmacokinetics of this drug with topical application is local in nature with minimal systemic absorption and rapid elimination of residues upon washing.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Mechanisms of Action and Scientific Justification: Anti-Inflammatory Soap with Pomegranate and Vitamin C

Liver and Gastrointestinal Tract: With accidental oral intake, the active compounds of pomegranate and chamomile undergo metabolism in the liver with the participation of conjugation enzymes (glucuronidation, sulfation). Pomegranate polyphenols act as lipotropic and membrane-stabilizing agents, reducing lipid peroxidation and modulating NF-κB and MAPK cascades. Ascorbic acid, entering the systemic bloodstream, enhances the antioxidant potential by restoring tocopherol and neutralizing reactive oxygen species.
References: PubMed, ScienceDirect

Immune System: Ellagic acid and pomegranate polyphenols exert a modulating effect on macrophages and neutrophils, reducing the production of pro-inflammatory cytokines and prostaglandins. Chamomile extract, due to α-bisabolol and chamazulene, additionally reduces histamine release and suppresses the activity of cyclooxygenase and lipoxygenase. Vitamin C acts as an additive immunomodulator, increasing the functional activity of phagocytes and stimulating antioxidant enzymes.
References: PMC, SpringerLink

Nervous System: Chamomile contains sesquiterpene compounds that demonstrate a sedative-modulating effect through interaction with GABA receptors, exerting a local soothing effect at the level of sensory nerve endings in the skin. Indirectly, the antioxidant properties of pomegranate and vitamin C can reduce oxidative stress in nerve cells, which manifests as a protective potential in cellular damage.
References: Wiley Online Library, Semantic Scholar

Endocrine and Metabolic Regulation: Pomegranate polyphenols influence the regulation of lipid and carbohydrate metabolism by modulating the activity of adipocytes and reducing the expression of pro-inflammatory genes in adipose tissue. Vitamin C participates in the biosynthesis of corticosteroids and catecholamines, affecting the endocrine-metabolic balance. Glycerin can be incorporated into gluconeogenesis and participate in energy metabolism. The interaction between these compounds is additive and modulating in nature, ensuring systemic and cellular maintenance of metabolic equilibrium.
References: Taylor & Francis, WHO IRIS

Thus, the mechanisms of action of the drug are due to the complex influence of its components on antioxidant, anti-inflammatory, and membrane-stabilizing cascades. The interaction is characterized as additive and potentiating, realized at the systemic and tissue-specific levels and aimed at maintaining cellular protection, reducing inflammatory activity, and normalizing metabolic processes.
References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library, Semantic Scholar, WHO.