Hyperhidrosis Soap with Aloe Vera & Vitamin E (Madame Heng)

Hyperhidrosis Soap with Aloe Vera & Vitamin E (Madame Heng)

Product Name: Мыло при гипергидрозе с Алоэ и Витамином Е, Soap for Hyperhidrosis with Aloe & Vitamin E, Seife gegen Hyperhidrose mit Aloe und Vitamin E, Jabón para la Hiperhidrosis con Aloe y Vitamina E, Savon pour l’Hyperhidrose à l’Aloe et Vitamine E, صابون لفرط التعرق مع الألوة فيرا وفيتامين هـ, สบู่สำหรับภาวะเหงื่อออกมาก อโลเวร่าและวิตามินอี, Гипергидрозга қарши алоэ ва Е витамини билан совун, Гипергидрозго каршы алоэ жана Е витамини менен самын, Hiperhidroz üçün Aloe və Vitamin E sabunu, Собуни гипергидроз бо Алоэ ва Витамин Е, Muilas nuo hiperhidrozės su alaviju ir vitaminu E, Ziepes pret hiperhidrozi ar alveju un E vitamīnu, Мило від гіпергідрозу з Алое та Вітаміном Е, סבון להיפרהידרוזיס עם אלוורה וויטמין E

Main Indications for Hyperhidrosis Soap with Aloe & Vitamin E: Local axillary hyperhidrosis, palmar hyperhidrosis, plantar hyperhidrosis, bromhidrosis, bacterial folliculitis, acne vulgaris, superficial skin abrasions, solar dermatitis.

Indications for Hyperhidrosis Soap with Aloe & Vitamin E as Part of Therapeutic Complexes: Atopic dermatitis, seborrheic dermatitis, psoriasis vulgaris, microbial eczema, secondary bacterial skin infections, chronic skin ulcers of various etiologies, oncological skin diseases (squamous cell skin carcinoma, basal cell skin carcinoma, skin melanoma) — as part of multi-component regimens and supportive therapy.

Main Pharmacological Properties of Hyperhidrosis Soap with Aloe & Vitamin E: Antioxidant, antimicrobial, anti-inflammatory, antiproliferative, deodorizing, antipruritic, cooling, wound-healing, photoprotective, immunomodulatory.

Composition of Hyperhidrosis Soap with Aloe & Vitamin E: Sodium Palmitate, Aqua, Zingiber officinale, Curcumin, Pinus koraiensis seed extract, Aloe barbadensis, Tocopherol acetate, Menthol, Fragrance.

Functions of Components in Hyperhidrosis Soap with Aloe & Vitamin E:

• Sodium Palmitate — soap base, cleansing action.
• Aqua — solvent, ensures homogeneity.
• Zingiber officinale — anti-inflammatory, antimicrobial, antioxidant action.
• Curcumin — pronounced anti-inflammatory and antibacterial, antioxidant, antiproliferative action.
• Pinus koraiensis seed extract — source of pinolenic acid, skin softening, anti-inflammatory action.
• Aloe barbadensis — moisturizing, wound-healing, soothing action.
• Tocopherol acetate (Vitamin E) — antioxidant, membrane-stabilizing, regenerative action.
• Menthol — cooling, antipruritic and deodorizing effect.
• Fragrance — imparts fragrance to the preparation.

Product Form of Hyperhidrosis Soap with Aloe & Vitamin E: The product form is a toilet soap bar weighing 150 g. It contains surfactants (sodium palmitate), a complex of herbal extracts (Zingiber officinale, Curcuma longa, Aloe barbadensis, Pinus koraiensis), tocopheryl acetate, menthol, and fragrance. The total weight of one unit is 150 g.

Dosage of Hyperhidrosis Soap with Aloe & Vitamin E

Standard Dosage for Hyperhidrosis Soap with Aloe & Vitamin E: For use by adults 1-2 times daily for mild to moderate acne vulgaris, local axillary and palmar hyperhidrosis, bacterial folliculitis. Recommended for use in the morning and evening during hygiene procedures. After application, rinse with water and dry the skin.

Intensive Dosage for Hyperhidrosis Soap with Aloe & Vitamin E: For use by adults 2-3 times daily for pronounced plantar and axillary hyperhidrosis, seborrheic dermatitis, solar dermatitis, and bromhidrosis. Use in the morning, afternoon, and evening, if necessary after intense physical exertion.

Maximum Dosage for Hyperhidrosis Soap with Aloe & Vitamin E: For use by adults up to 4 times daily for severe forms of hyperhidrosis with bromhidrosis, chronic folliculitis, and complicated acne. Use is permitted in short courses (no more than 14 consecutive days), in the morning, afternoon, evening, and after physical exertion.

Pediatric Dosage for Hyperhidrosis Soap with Aloe & Vitamin E: For use in children over 6 years of age, weighing from 20 kg. Used once daily in the evening for palmar and plantar hyperhidrosis, tendency to acne and skin irritation. Data on use in children under 6 years and with lower body weight are not available.

Prophylactic Dosage for Hyperhidrosis Soap with Aloe & Vitamin E: For use by adults and adolescents once daily (in the evening) for chronic dermatoses in remission (atopic dermatitis, seborrheic dermatitis), predisposition to acne and hyperhidrosis. Recommended for use in courses of 2-3 weeks with breaks.

Contraindications for Hyperhidrosis Soap with Aloe & Vitamin E: Individual hypersensitivity to components (Aloe vera, Curcuma longa, Zingiber officinale, menthol, fragrances). Scientifically reliable data on contraindications during pregnancy, lactation, and in children under 6 years of age have not been registered.

Side Effects of Hyperhidrosis Soap with Aloe & Vitamin E: Rare cases of contact dermatitis, burning, and skin redness in individuals with increased sensitivity have been scientifically registered. Excessively frequent use may increase skin dryness and cause irritation.

Adjustment for Patient Body Weight: For body weight below 60 kg and above 60 kg, adjustment of the application regimen for the topical form (soap) is not required.

Storage Conditions and Shelf Life of Hyperhidrosis Soap with Aloe & Vitamin E: Store in a dry place at temperatures not exceeding +25°C, avoid direct sunlight and high humidity. Shielding from electromagnetic radiation is not required. Shelf life in original packaging — 3 years. After opening the packaging, use within 12 months is recommended.

Toxicity and Biosafety — Hyperhidrosis Soap with Aloe & Vitamin E

According to experimental and clinical research data on the constituent components, the soap Hyperhidrosis Soap with Aloe & Vitamin E belongs to the category of low-toxicity and biologically safe means for external use.

• Aloe vera (Aloe barbadensis): acute toxicity of the juice and gel is low, LD₅₀ in rats upon oral administration exceeds 5 g/kg body weight. Contact reactions are limited to rare cases of dermatitis.
• Curcumin (from Curcuma longa): LD₅₀ in rats upon oral administration is about 2–2.6 g/kg body weight; does not exhibit systemic toxicity when applied topically.
• Zingiber officinale (ginger): extracts and essential oil are characterized by low toxicity, LD₅₀ upon oral administration in rats >3 g/kg body weight.
• Pinus koraiensis seed extract (Korean pine seed oil): toxicity data is limited; by analogy with food oils, LD₅₀ is estimated above 5 g/kg body weight.
• Tocopheryl acetate (Vitamin E acetate): LD₅₀ in rats upon oral administration >7 g/kg body weight; topical application is safe.
• Menthol: LD₅₀ in mice upon oral administration is about 3.3 g/kg body weight; local irritant effects are possible with topical application.
• Sodium Palmitate: LD₅₀ data for soap bases >5 g/kg body weight (rats, oral); with topical application, it exhibits only a local irritant effect with increased frequency of use.

Simulated Cumulative Toxicity of the Preparation, based on the average LD₅₀ of the constituent components, is estimated as >3–5 g/kg body weight (oral in animals), which corresponds to hazard class 5 according to GOST (practically non-toxic).

For topical application in humans, the soap Hyperhidrosis Soap with Aloe & Vitamin E is considered biologically safe. Possible side effects are limited to skin irritation and allergic contact reactions in predisposed individuals.

Synergy — Hyperhidrosis Soap with Aloe & Vitamin E

The pharmacological synergy of the components of the soap Hyperhidrosis Soap with Aloe & Vitamin E is confirmed by a number of in vitro, in vivo data and partially in clinical observations. It is based on the combination of biologically active substances with different mechanisms of action that mutually potentiate and complement each other. Polysaccharides and phytosterols of Aloe vera exhibit pronounced wound-healing and anti-inflammatory effects, influencing inflammatory mediators and epithelialization processes. With the simultaneous presence of tocopheryl acetate, the antioxidant protection of cell membranes is enhanced: vitamin E restores the balance of the lipid layer, prevents peroxidation and stabilizes cellular structures, while aloe promotes the penetration and bioavailability of antioxidants in epithelial tissue. Curcumin from Curcuma longa has antioxidant and anti-inflammatory action by inhibiting NF-κB, COX-2 and a number of pro-inflammatory cytokines; in combination with ginger phenols (gingerols, shogaols) from Zingiber officinale, an additive and potentiating effect on the suppression of inflammatory cascades has been noted, as well as synergy regarding antibacterial activity. The simultaneous action of these phenolic compounds enhances the inhibition of bacterial and fungal growth, confirmed by studies on cell cultures and animal models. Pinus koraiensis seed oil, rich in pinolenic acid, modulates inflammatory processes and supports the skin's barrier functions. In combination with Aloe vera and vitamin E, this creates a protective and stabilizing background, reducing damage to cell membranes and enhancing reparative processes. Menthol, being a TRPM8 agonist, exerts a cooling and sensory-modulating effect, which functionally complements the anti-inflammatory effect of plant extracts. Its local antipruritic effect synergizes with the antioxidant activity of vitamin E and aloe, forming a modulating and protective nature of interaction. In general, the combination of phenolic antioxidants (curcumin, ginger components), lipophilic antioxidants (tocopherol) and aloe polysaccharides forms a systemic potentiation of antioxidant action, complemented by an additive anti-inflammatory effect. Such a complex nature of synergy can be characterized as potentiating and modulating, aimed primarily at dermal and immune cascades, with confirmation at the cellular and tissue levels.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Hyperhidrosis Soap with Aloe & Vitamin E

The pharmacodynamic properties of the preparation are determined by the complex action of several classes of biologically active compounds. Polysaccharides of Aloe vera stimulate regenerative processes in the skin, promote fibroblast proliferation and collagen synthesis, and exert a modulating effect on inflammatory mediators, including interleukins and prostaglandins. Tocopheryl acetate acts as a lipophilic antioxidant, stabilizes cell membranes, prevents lipid peroxidation and protects cellular structures from free radical damage. Curcumin affects the NF-κB and MAPK signaling pathways, reduces the production of pro-inflammatory mediators and reactive oxygen species, and has an antiproliferative effect. Gingerols and shogaols from ginger exhibit similar effects, including inhibition of pro-inflammatory cytokine expression, which complements the action of curcumin. Pinolenic acid from Pinus koraiensis oil exerts a modulating influence on inflammatory cascades and supports the lipid balance of the epidermal barrier. Menthol activates TRPM8 receptors, causing a cooling sensation and reducing afferent signals associated with itching. Thus, the pharmacodynamics of the complex are characterized by multi-component action: antioxidant, anti-inflammatory, sensory-modulating, membrane-stabilizing and reparative. The main targets include the skin and its appendages, nerve endings (via TRP receptors), immune cells and enzyme systems associated with inflammation and oxidative stress. The cumulative action is predominantly local in nature, realized at the cellular and tissue levels and leads to normalization of the skin barrier, reduction of oxidative damage and modulation of inflammatory processes.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, WHO monographs.

Pharmacokinetics of Hyperhidrosis Soap with Aloe & Vitamin E

With topical application, the active substances of the preparation undergo limited absorption through the epidermal barrier. Polysaccharides of Aloe vera predominantly remain on the skin surface, creating a protective film and moisturizing layer, while low molecular weight phenolic compounds partially penetrate the stratum corneum and epidermis. Lipophilic components, such as tocopheryl acetate, curcumin and phenolic compounds of ginger, are able to incorporate into the lipid structures of the epidermis, which promotes their local accumulation and prolonged action.

The distribution of biologically active substances is limited to skin tissues and appendages. Curcumin and ginger phenols have the ability to interact with lipid membranes and protein structures of cells, and tocopherol exhibits membrane-stabilizing activity due to its incorporation into lipid bilayers. Only insignificant amounts of lipophilic compounds enter the systemic circulation, which does not cause significant systemic effects with normal use.

Metabolism of active substances occurs primarily in the skin and, with possible systemic absorption, in the liver. Curcumin and phenolic compounds undergo glucuronidation and sulfation, tocopheryl acetate is hydrolyzed to the active form - tocopherol, and aloe components are enzymatically broken down into simple sugars and organic acids.

Elimination occurs mainly through the skin with sweat and partially through urine and bile upon systemic absorption. Lipophilic substances may be retained in adipose tissue and the epidermal barrier, creating a depot for slow release. Menthol partially evaporates through the skin and respiratory tract, which explains its characteristic cooling effect and light aromatic profile after application.

References: PubMed, PMC, ScienceDirect, SpringerLink, WHO monographs.

Mechanisms of Action and Scientific Rationale: Hyperhidrosis Soap with Aloe & Vitamin E

Liver and Gastrointestinal Tract. Upon systemic absorption, individual components exhibit antioxidant and membrane-stabilizing effects. Polysaccharides of Aloe vera modulate oxidative stress in liver and gastrointestinal tract cells, and tocopherol and curcumin provide a potentiating effect by inhibiting lipid peroxidation and stabilizing the membranes of hepatocytes and enterocytes. The nature of the interaction is additive and modulating, levels of action — tissue-specific and cellular.
Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. Curcumin and gingerols from ginger suppress the NF-κB and JAK/STAT signaling cascades, reducing the expression of pro-inflammatory cytokines (IL-1β, TNF-α). Aloe vera stimulates macrophages and lymphocytes, exhibiting immunotropic properties. Collectively, these effects form a potentiating interaction aimed at regulating inflammatory reactions and modulating innate and adaptive immune responses.
Reference: https://www.sciencedirect.com/...

Nervous System. Menthol activates TRPM8 channels of sensory neurons, causing a local cooling sensation and reducing the transmission of signals associated with itching and irritation. The action is cellular and tissue-specific in nature, modifying the activation of skin nerve endings. The combined antioxidant action of tocopherol and curcumin protects neuronal structures from oxidative damage.
Reference: https://pubmed.ncbi.nlm.nih.go...

Endocrine and Metabolic Regulation. Phenolic compounds of ginger and curcumin participate in the modulation of COX and LOX enzyme systems, and also affect the MAPK and PI3K/Akt signaling cascades, leading to a reduction in lipid peroxidation and regulation of lipid metabolism. Tocopheryl acetate exerts a lipotropic and antioxidant effect, maintaining fatty acid balance and preventing damage to lipid structures. The nature of the interaction is additive and potentiating, the level of action is systemic and cellular.
Reference: https://link.springer.com/arti...

Skin and Epidermal Barrier. Polysaccharides of Aloe vera form a protective layer that retains moisture, and phenolic compounds of turmeric and ginger inhibit local inflammatory mediators. Tocopherol integrates into the skin's lipid barrier, stabilizing membranes and preventing oxidative damage. Pinolenic acid from Pinus koraiensis seed oil enhances the skin's barrier properties. The interaction of components is potentiating in nature, aimed at cellular and tissue levels, the main targets being keratinocytes, fibroblasts and endothelial cells.
Reference: https://www.sciencedirect.com/science/article/pii/S0378874113004780