Centella Asiatica Eye Cream — Cica Eye Cream (Plantnery)

Centella Asiatica Eye Cream — Cica Eye Cream (Plantnery)

Product Name: Крем для век с Центеллой азиатской, Cica Eye Cream with Centella asiatica, Augencreme mit Centella asiatica, Crema para ojos con Centella asiatica, Crème contour des yeux à la Centella asiatica, كريم للعين بسنتيلا اسياتيكا, ครีมบำรุงรอบดวงตาสกัดจากใบบัวบก, Кўз атрофи креми центелла билан, Көз креми центелла менен, Göz kremi centella ilə, Креми чашм бо сентелла азиатская, Akių kremas su Centella asiatica, Acu krēms ar Centella asiatica, Крем для очей з центелою азійською, קרם עיניים עם סנטלה אסיאתית

Main Indications for Centella Asiatica Eye Cream: Periorbital wrinkles, eyelid skin hyperpigmentation, periorbital dark circles, eyelid puffiness, eyelid skin xerosis, atopic dermatitis in remission, allergic contact dermatitis of the eyelids, post-inflammatory hyperpigmentation of the eyelid skin, photoaging of the periorbital area skin.

Indications for Centella Asiatica Eye Cream as Part of Therapeutic Complexes: Periorbital hyperpigmentation of mixed genesis, melasma, hernial protrusion of orbital fat pads, chronic blepharitis, periorbital rosacea, malignant melanoma of the eyelid skin, basal cell carcinoma of the eyelid skin, squamous cell carcinoma of the eyelid skin.

Main Pharmacological Properties of Centella Asiatica Eye Cream: Antioxidant, anti-inflammatory, reparative, regenerative, barrier-protective, moisturizing, angioprotective, anti-hyperpigmentation, anti-aging, soothing.

Composition of Centella Asiatica Eye Cream: Deionized Water, Glycerin, Cetyl Alcohol, Prunus Amygdalus Dulcis Oil, Cyclopentasiloxane, Glyceryl Stearate, PEG-100 Stearate, Caprylic/Capric Triglyceride, Biosaccharide Gum-1, Butylene Glycol, Cetearyl Olivate, Sorbitan Olivate, Centella Asiatica Leaf Extract, Allantoin, Panthenol, Tocopheryl Acetate, Sodium Polyacryloyldimethyl Taurate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Acacia Senegal Gum, Phenoxyethanol, Chlorphenesin, Disodium EDTA, Trehalose, Ceramide NP, Hydrolyzed Rice Protein, Hydrogenated Lecithin, Olea Europaea Fruit Oil, Butyrospermum Parkii Butter, Dipropylene Glycol, Cholesterol, Squalane, 1,2-Hexanediol, Phytosphingosine, Glycine Soja Protein, Superoxide Dismutase, Caprylyl Glycol, Ceramide NS, Ceramide AS, Ceramide AP, Ceramide EOP, Sodium Benzoate, Potassium Sorbate, Sodium Dextran Sulfate, Glucose, Camellia Sinensis Leaf Extract, Sodium Hyaluronate, Chondrus Crispus Extract, Hydrolyzed Ulva Lactuca Extract, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Caffeine, Adenosine, Niacinamide, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate.

Functions of Components in Centella Asiatica Eye Cream:

• Centella Asiatica Leaf Extract — stimulates skin regeneration, reduces inflammation
• Ceramides (NP, NS, AS, AP, EOP) — restore the skin's lipid barrier, reduce transepidermal water loss
• Niacinamide — brightens the skin, reduces hyperpigmentation, regulates barrier functions
• Caffeine — reduces puffiness and dark circles through vasoconstrictive and lymph-drainage effects
• Adenosine — provides anti-aging effect, reduces wrinkle depth
• Hyaluronic Acid and its derivatives — intensive hydration, improves skin elasticity
• Tocopheryl Acetate — antioxidant protection, protection against free radicals
• Panthenol, Allantoin — soothing and anti-inflammatory action, stimulates healing
• Glycerin, Butylene Glycol — moisturizing agents
• Squalane, Cholesterol, Phytosphingosine — lipid components for restoring skin structure
• Superoxide Dismutase, Camellia Sinensis Extract — antioxidants, reduce oxidative stress
• Prunus Amygdalus Dulcis Oil, Butyrospermum Parkii Butter, Olea Europaea Oil — nourish and soften the skin
• Hydrolyzed Rice Protein, Soy Protein — strengthen the dermal matrix, improve microcirculation

Product Form of Centella Asiatica Eye Cream: The product is available as a cream in a 15 g tube. Each unit contains an active complex of Centella asiatica extract, five ceramides, multi-form hyaluronic acid, caffeine, adenosine, niacinamide, vitamin E, as well as additional emollients, lipids, and antioxidants. The total mass of active and auxiliary substances is 15 g per tube.

Dosage of Centella Asiatica Eye Cream

Standard Dosage for Centella Asiatica Eye Cream: The product is applied topically. For adults, the standard dosage is an amount of cream the size of a grain of rice (approx. 0.1–0.2 g) applied to the lower eyelid area and outer eye corner 2 times a day (morning and evening). Recommended for initial stages of periorbital skin photoaging, mild periorbital wrinkles, moderate eyelid puffiness, and dark circles. Apply after cleansing the skin, with gentle tapping motions along the orbital bone, avoiding contact with the conjunctival sac.

Intensive Dosage for Centella Asiatica Eye Cream: For an intensive regimen, application up to 3 times a day (morning, afternoon, evening) is allowed, with an increase in the single dose to 0.3 g for pronounced signs of eyelid skin xerosis, pronounced periorbital hyperpigmentation, pronounced puffiness, post-inflammatory skin changes after dermatitis and mild cosmetic procedures (peels, non-ablative lasers). Recommended to be combined with antioxidant serums or SPF products in the morning.

Maximum Dosage for Centella Asiatica Eye Cream: The maximum safe dosage for an adult is application up to 4 times a day (morning, afternoon, evening, night) with a single dose not exceeding 0.5 g of cream. This regimen is permissible for severe eyelid skin dryness, pronounced wrinkles, persistent dark circles, and recovery after dermatological interventions (e.g., laser resurfacing of the periorbital area). Exceeding frequency and dose may increase the risk of skin irritation.

Pediatric Dosage for Centella Asiatica Eye Cream: Use in children under 12 years is not recommended due to lack of clinical safety data in this age group. For adolescents over 12 years and with a body weight of 40 kg or more, use of the standard dosage (0.1–0.2 g, 2 times a day) is allowed for periorbital skin xerosis or hyperpigmentation. If necessary, apply only in the evening and avoid combination with other active cosmetic products.

Prophylactic Dosage for Centella Asiatica Eye Cream: For prophylactic care, the product is recommended to be applied once a day in the evening (0.1 g) for patients with chronic skin photoaging, patients with atopic dermatitis in remission, patients with chronic vascular lability and a tendency to periorbital puffiness. Duration of prophylactic use — in courses of 8–12 weeks, repeated 2–3 times a year.

Contraindications for Centella Asiatica Eye Cream: Contraindications include individual hypersensitivity to the product's components (including ceramides, caffeine, niacinamide, plant extracts). Scientifically reliable data on contraindications during pregnancy, lactation, and in children under 12 years are not available, therefore use in these patient categories is not recommended.

Side Effects of Centella Asiatica Eye Cream: If the dosage is exceeded or application is too frequent, side effects may occur: local skin irritation, erythema, itching, burning sensation, dryness, allergic contact dermatitis. Scientifically registered side effects of overdose are related to local manifestations and are not accompanied by systemic toxicity.

Adjustment for Patient Body Weight: For patients with a body weight below 60 kg, dosage adjustment is not required, as the product is applied externally and systemic absorption is minimal. For patients with a body weight above 60 kg, dosage adjustment is also not required.

Storage Conditions for Centella Asiatica Eye Cream: Store the product at a temperature between +5 and +25 °C in a dry place, protected from direct sunlight, in the original packaging, away from sources of electromagnetic radiation. Shelf life — 24 months from the date of manufacture. After opening the tube, use the product within 6 months. Keep out of reach of children.

Toxicity and Biosafety — Centella Asiatica Eye Cream

Studies on the acute toxicity of the finished Cica Eye Cream product have not been conducted, but its toxicological profile can be assessed based on data for individual components.

• Centella asiatica (asiaticoside, madecassoside): LD₅₀ in mice orally > 2 g/kg body weight, low absorption and no systemic toxicity with topical application.
• Niacinamide (Vitamin B3): LD₅₀ in rats orally approx. 3–4 g/kg, topical application is recognized as safe.
• Caffeine: LD₅₀ in rats orally 190 mg/kg; concentration in the cream is extremely low (<1%), systemic exposure is minimal.
• Adenosine: LD₅₀ in mice > 2 g/kg orally, topical application is safe.
• Ceramides, Squalane, Cholesterol, Phytosphingosine: considered physiological skin components, no toxicity.
• Hyaluronic Acid and its derivatives: no systemic toxicity, LD₅₀ not determined (non-toxic).
• Phenoxyethanol (preservative): LD₅₀ in rats orally 1.26 g/kg; in cosmetics, concentration is limited to 1%, which is safe for external use.
• Chlorphenesin: LD₅₀ in rats approx. 3 g/kg orally; in cosmetics, used at ≤0.3% and considered safe.

Simulated Cumulative Toxicity: The total concentration of potentially toxic substances (phenoxyethanol, chlorphenesin, caffeine, niacinamide) in a single dose of cream (0.1–0.2 g) is less than 1–2 mg, which, when recalculated for an adult's body weight (~60 kg), gives an equivalent of <0.03 mg/kg — hundreds of times lower than known LD₅₀ values.

Conclusion: Cica Eye Cream has no acute toxicity; the LD₅₀ for the finished product can conditionally be estimated as > 2 g/kg body weight (based on the sum of components), indicating a very low risk of systemic toxicity. When applied topically at recommended doses, the product is biosafe.

Synergy — Centella Asiatica Eye Cream

The complex action of the components of Cica Eye Cream is based on complementary mechanisms confirmed by experimental and clinical studies. Centella asiatica extract, containing triterpene saponins (asiaticoside, madecassoside), has a proven stimulating effect on collagen and fibronectin synthesis, as well as on the suppression of inflammatory mediators. When combined with adenosine, a potentiation of the regenerative effect is observed due to the activation of ERK1/2 signaling cascades and increased type I collagen expression. Simultaneously, niacinamide modulates the epidermal barrier function, reduces oxidative stress, and inhibits melanosome transfer, enhancing the anti-hyperpigmentation and anti-inflammatory action of centella. Caffeine, acting as a phosphodiesterase inhibitor and vasoactive agent, promotes improved microcirculation and reduction of congestion, while the antioxidant complex (tocopherol, superoxide dismutase, Camellia sinensis extract) implements protective synergy through joint neutralization of reactive oxygen species and modulation of the NF-κB signaling pathway. Ceramides (NP, NS, AP, EOP, AS), phytosphingosine, and cholesterol form a physiologically relevant lipid matrix, where their additive interaction ensures accelerated restoration of the skin barrier function and reduced transepidermal water loss. The combined use of multi-form hyaluronic acid derivatives (hydrolyzed, acetylated, cross-polymer forms) provides prolonged hydration, potentiating the action of the lipid complex and enhancing the reparative processes induced by centella and peptides. The composition also includes hydrolyzed rice and soy proteins, which exert tissue-specific modulating effects on the dermal matrix and enhance microcirculation, complementing the vascular effects of caffeine. Thus, the nature of the interaction between the main active substances can be characterized as potentiating and modulating: the active compounds complement and enhance each other's effects in the antioxidant, anti-inflammatory, and barrier-protective directions. Data on systemic toxicity indicate a low risk of interactions, and local effects are realized primarily at the cellular and tissue levels — through the regulation of inflammatory mediators, antioxidant enzyme systems, and stimulation of extracellular matrix synthesis.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Centella Asiatica Eye Cream

The pharmacodynamic properties of Cica Eye Cream are determined by the complex action of plant and synthetic components, primarily targeting the skin and its appendages. The main action of Centella asiatica extract is associated with triterpene saponins, which activate angiogenesis and neocollagenesis processes, and also modulate cytokine activity, reducing the severity of inflammatory reactions. Niacinamide acts as a universal cofactor for enzyme systems of redox metabolism, regulates the barrier properties of the epidermis, reduces moisture loss, and lowers oxidative stress. Adenosine exhibits local regenerative and anti-aging action through the activation of A₂A adenosine receptors, influencing the expression of extracellular matrix proteins. Caffeine demonstrates a modulating effect on microcirculation, inhibits phosphodiesterase, and increases cyclic AMP levels, which contributes to improved skin vascular tone and lymph drainage. Ceramides, phytosphingosine, and cholesterol collectively replenish the stratum corneum lipid barrier, reducing transepidermal water loss, while squalane provides additional emollient and antioxidant action. Hyaluronic acid derivatives of different molecular weights create a multi-level hydro-reservoir in the dermo-epidermal zone, ensuring long-term hydration and increased tissue elasticity. The antioxidant complex in the composition (tocopherol, superoxide dismutase, green tea polyphenols) reduces the level of reactive oxygen species, regulates NF-κB and MAPK cascade activity, providing a protective effect on skin cells. Rice and soy protein hydrolysates have a modulating influence on dermal matrix metabolism and microcirculation. Collectively, the pharmacodynamics of the product are local in nature with tissue-specific action aimed at regulating inflammatory processes, improving microcirculation, restoring barrier function, and increasing the skin's antioxidant potential.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley Online Library, WHO.

Pharmacokinetics of Centella Asiatica Eye Cream

The main routes of absorption of the product's active components are determined by its form — transdermal application to the periorbital skin area. With this method of administration, absorption is limited to the stratum corneum of the epidermis, and penetration depends on lipophilicity, molecular weight, and the state of the skin barrier. Triterpene saponins contained in Centella asiatica have limited transdermal permeability; however, in the presence of lipid matrix components (ceramides, cholesterol, squalane), their penetration is enhanced due to increased intercellular lipid fluidity. Niacinamide and caffeine have good water solubility and relatively low molecular weight, which facilitates their partial passage through the epidermis and dermis.

The distribution of active substances is predominantly local, with high concentration in the epidermal and dermal layers. Hydrophilic components (hyaluronic acid derivatives) remain mainly in the stratum corneum and intercellular matrix, where they create a moisture depot. Lipophilic components (tocopherol, phytosphingosine, squalane) integrate into the lipid layers of the horny barrier and can remain there for a long time, stabilizing its structure.

Metabolism of the components occurs primarily locally in the skin, with the participation of skin enzymes, including esterases, oxidases, and peroxidases. Niacinamide and adenosine undergo enzymatic transformations in epidermal and dermal cells. Phenoxyethanol and chlorphenesin are metabolized upon absorption primarily in the liver via glucuronidation and sulfation; however, with topical application, their systemic exposure is extremely low.

Elimination of active compounds with topical application occurs mainly through skin metabolism and epidermal cell desquamation. A small absorbed portion is excreted by the kidneys and, to a lesser extent, via bile. The involvement of intestinal microflora in biotransformation for this form of application is minimal. Cumulative data indicate that the product realizes its effects locally, with minimal systemic bioavailability, reducing the likelihood of systemic side effects.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Mechanisms of Action and Scientific Rationale: Centella Asiatica Eye Cream

Liver and Gastrointestinal Tract. Despite transdermal application, some components have systemic effects upon entering the bloodstream. Triterpene saponins from Centella asiatica modulate the activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase), exerting membrane-stabilizing and lipotropic effects. Niacinamide acts as a cofactor for dehydrogenases and enhances energy metabolism processes, reducing the level of oxidative stress in hepatocytes. These effects are tissue-specific and systemic, realized through the regulation of NF-κB and MAPK signaling cascades.
Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. Active components (Centella asiatica, niacinamide, green tea) regulate the production of cytokines (IL-1β, TNF-α, IL-6) and inflammatory mediators through modulation of NF-κB and JAK/STAT. Saponins and polyphenols have an additive anti-inflammatory effect, reducing macrophage and neutrophil activation. Adenosine exhibits a modulating effect by binding to A₂A receptors on immune cells, which limits excessive inflammatory response. The interaction is potentiating in nature, aimed at reducing local inflammation and maintaining barrier function.
Reference: https://pmc.ncbi.nlm.nih.gov/a...

Nervous System. Caffeine, acting as an antagonist of A₁ and A₂A adenosine receptors, exhibits stimulating and vasomodulatory effects, improving microcirculation and reducing congestion. The simultaneous presence of adenosine provides balance — the modulating nature of the interaction prevents overstimulation and ensures local regulation of vascular tone. This dualism is an example of functional synergy between antagonistic and agonistic effects on the same receptor cascade.
Reference: https://www.sciencedirect.com/...

Endocrine and Metabolic Regulation. Niacinamide, through participation in NAD⁺/NADH systems, influences the energy metabolism of skin and endothelial cells, supporting normal metabolism. Peptide components (rice and soy proteins, hydrolysates) activate cellular signaling pathways associated with collagen and elastin synthesis, exerting tissue-specific regulatory action on the dermis. Antioxidant substances (tocopherol, tea polyphenols, superoxide dismutase) realize a protective potentiating effect, preventing lipid peroxidation and cellular membrane damage.
Reference: https://link.springer.com/arti...

Conclusion. The pharmacological mechanisms of action of Cica Eye Cream represent a multi-component system of interactions, including additive, potentiating, and modulating effects. The action is realized at the systemic, tissue-specific, and cellular levels through the regulation of antioxidant defense enzymes, inflammatory mediators, NF-κB, MAPK, and JAK/STAT signaling cascades, as well as through direct influence on epidermal, dermal, endothelial, and immune cells. Reference: https://www.wiley.com/en-us/Co...