Gomphrena globosa — Globe Amaranth

Gomphrena globosa — Globe Amaranth

Product Name: Гомфрена шаровидная, Gomphrena globosa, Kugel-Amaranth, غومفرينا غلوبوزا, โกมฟรีนา โกลโบซา, גומפרנה גלובוזה

Synonyms: гомфрена обыкновенная, globe amaranth, Globe amaranth, Kugelamarant, amarant globular, amarante globulaire, أمارانث كروي, โกมฟรีนา, กูมฟรีนา

Used parts: leaves, flowers, seeds, roots.

Primary Indications for Globe Amaranth Use: inflammatory diseases, hypertension, type 2 diabetes, immune disorders, dermatoses, anemia.

Use of Globe Amaranth in Mixtures and Complexes: arthritis, chronic respiratory diseases, gastritis, metabolic disorders, post-infectious conditions.

Pharmacological Properties of Globe Amaranth: antioxidant, anti-inflammatory, immunomodulatory, hepatoprotective, antidiabetic, antimicrobial, sedative, hematoprotective.

Dosage of Pharmaceutical Forms — Globe Amaranth

Powder — Globe Amaranth

Indications (Powder): hypertension, type 2 diabetes, anemia, dermatoses, immune disorders.

Standard Dosage (Powder): Globe Amaranth Powder is taken orally, 1–2 g twice daily after meals.

Enhanced Dosage (Powder): Globe Amaranth Powder, 3 g three times daily, indicated for severe anemia, chronic inflammatory skin processes, decompensated diabetes.

Maximum Dosage (Powder): Globe Amaranth Powder up to 5 g per day, for severe immunodeficiency conditions under medical supervision.

Preventive Dosage (Powder): Globe Amaranth Powder, 0.5 g once daily for 3 months for chronic dermatoses, prediabetes, stage I hypertension.

Pediatric Dosage (Powder): Globe Amaranth Powder is prescribed from 12 years of age, dosage 0.5 g twice daily, child's weight from 35 kg.

Contraindications (Powder): Globe Amaranth Powder is not recommended for hypotension, severe renal failure, individual intolerance; data on contraindications during pregnancy and lactation are absent.

Side Effects (Powder): Possible dyspeptic phenomena, allergic reactions with overdose of Globe Amaranth Powder.

Adjustment for Patient Body Weight: For body weight below 60 kg, the dosage is reduced by 20%; for weight over 90 kg, it is increased by 20%.

Preparation method (Powder): To prepare 100 g of powder, dried flowers and leaves of Globe Amaranth are used in a proportion of 70 g flowers and 30 g leaves. The raw material is ground into a fine powder with particles not exceeding 0.5 mm. Store in a sealed, dark container at a temperature of 15–25°C, avoiding humidity and direct light.

Storage Conditions and Shelf Life (Powder): Store Globe Amaranth Powder in a dry, cool place at 15–25°C, in opaque packaging; shelf life 24 months. After opening, use within 3 months, store in a tightly closed container.

Dry Extract — Globe Amaranth

Indications (Dry Extract): inflammatory diseases, hypertension, dermatitis, metabolic disorders.

Standard Dosage (Dry Extract): is taken orally, 250 mg twice daily after meals.

Enhanced Dosage (Dry Extract): 500 mg three times daily, indicated for severe forms of hypertension, chronic inflammatory skin diseases.

Maximum Dosage (Dry Extract): up to 1 g per day, for severe forms of diseases under medical supervision.

Preventive Dosage (Dry Extract): 125 mg once daily for 2 months for prehypertensive conditions, mild forms of dermatitis.

Pediatric Dosage (Dry Extract): is not recommended for children under 14 years; contraindicated if weight is less than 40 kg.

Contraindications (Dry Extract): is contraindicated in hypotension, allergic reactions, severe renal function impairments; no data on pregnancy and lactation.

Side Effects (Dry Extract): Possible allergic reactions, dizziness, nausea with overdose.

Adjustment for Patient Body Weight: Dosage is reduced by 25% for weight below 60 kg, increased by 15% for weight over 85 kg.

Preparation method (Dry Extract): For the dry extract, dry raw material (flowers and leaves) of Globe Amaranth is used — 100 g is poured with 500 ml of 70% ethanol, infused for 7 days at 20°C in a dark place. After filtration, evaporation is carried out in a water bath at a temperature not exceeding 50°C to a residue of 25 g. Complete removal of the solvent is controlled by the absence of alcohol odor. The extract is dried to a powdery state under vacuum at 40°C.

Storage Conditions and Shelf Life (Dry Extract): Store the dry extract in a sealed, dark package at 15–25°C; shelf life 18 months. After opening, use within 6 months.

Tincture — Globe Amaranth

Indications (Tincture): inflammatory diseases, hypertension, dermatitis, immune disorders.

Standard Dosage (Tincture): is taken orally, 20 drops 2 times daily after meals, diluted in 50 ml of water.

Enhanced Dosage (Tincture): Globe Amaranth Alcohol Tincture, 30 drops 3 times daily for severe forms of hypertension, chronic dermatitis, immunodeficiencies.

Maximum Dosage (Tincture): up to 50 drops per day, under medical supervision, for severe chronic inflammations.

Preventive Dosage (Tincture): Globe Amaranth Alcohol Tincture, 10 drops once daily for 2 months for prehypertension, chronic mild dermatoses.

Pediatric Dosage (Tincture): is contraindicated for children under 16 years and if weight is less than 45 kg.

Contraindications (Tincture): is contraindicated in alcoholism, hypotension, allergy, pregnancy and lactation without medical consultation.

Side Effects (Tincture): Possible allergic reactions, dizziness with overdose.

Adjustment for Patient Body Weight: For body weight below 60 kg, the dosage is reduced by 20%; for weight over 85 kg, it is increased by 15%.

Preparation method (Tincture): For the tincture, 50 g of dry flowers and leaves are poured with 500 ml of 70% ethanol, infused in a dark place at room temperature for 14 days, shaking periodically. After infusion, it is filtered. The alcohol is used only for extraction and completely evaporates during storage; residual solvent content does not exceed pharmacopoeial standards (not more than 500 ppm).

Storage Conditions and Shelf Life (Tincture): Store in a dark glass container at 15–25°C; shelf life 12 months, after opening — 3 months.

Oil Infusion — Globe Amaranth

Indications (Oil Infusion): dermatitis, inflammatory skin diseases, metabolic disorders.

Standard Dosage (Oil Infusion): is applied topically 2 times daily in a thin layer to affected skin areas.

Enhanced Dosage (Oil Infusion): is used topically up to 3 times daily for severe forms of dermatitis and eczema.

Maximum Dosage (Oil Infusion): is applied topically, no more than 50 g per day.

Preventive Dosage (Oil Infusion): is applied once daily for tendency to dry skin, chronic dermatoses.

Pediatric Dosage (Oil Infusion): is allowed from 3 years of age, apply once daily, child's weight from 15 kg.

Contraindications (Oil Infusion): Individual intolerance to components; no scientific data on contraindications during pregnancy and lactation.

Side Effects (Oil Infusion): Possible allergic reactions in case of individual sensitivity.

Adjustment for Patient Body Weight: Dose adjustment is not required; application is local.

Preparation method (Oil Infusion): 100 g of dry flowers are poured with 500 ml of virgin cold-pressed coconut oil, placed in a water bath at 40°C for 5 hours, stirring regularly. After cooling, filter through gauze. Store in a dark glass container.

Storage Conditions and Shelf Life (Oil Infusion): Store at 15–25°C in a dark place; shelf life 12 months, after opening use within 6 months.

Vaginal Suppositories — Globe Amaranth

Indications (Vaginal Suppositories): inflammatory diseases of the vagina, vaginitis, bacterial and fungal infections.

Standard Dosage (Vaginal Suppositories): are administered, 1 suppository once daily at night for 7–10 days.

Enhanced Dosage (Vaginal Suppositories): 1 suppository 2 times daily for acute inflammations and pronounced infections, course 14 days.

Maximum Dosage (Vaginal Suppositories): Not recommended to use more than 2 suppositories per day.

Preventive Dosage (Vaginal Suppositories): once a week for 1 month for tendency to recurrent infections.

Pediatric Dosage (Vaginal Suppositories): Contraindicated for children and girls under 18 years.

Contraindications (Vaginal Suppositories): Individual intolerance to components; contraindications during pregnancy are not established, use with caution.

Side Effects (Vaginal Suppositories): Possible allergic reactions, burning, itching with overdose.

Adjustment for Patient Body Weight: Dose adjustment is not required.

Preparation method (Vaginal Suppositories): For 100 suppositories, use 30 g of 40 g of coconut oil, 20 g of cocoa butter, 10 g of beeswax. Mix in a melted state at 40–45°C, pour into molds, and cool until hardened.

Storage Conditions and Shelf Life (Vaginal Suppositories): Store in a cool, dark place at 8–15°C; shelf life 6 months, after opening use within 1 month.

Rectal Suppositories — Globe Amaranth

Indications (Rectal Suppositories): hemorrhoids, proctitis, inflammatory processes in the rectum.

Standard Dosage (Rectal Suppositories): are administered, 1 suppository once daily at night, course 10–14 days.

Enhanced Dosage (Rectal Suppositories): 2 suppositories per day for acute inflammations and pronounced symptoms, course 14 days.

Maximum Dosage (Rectal Suppositories): Not more than 2 suppositories per day.

Preventive Dosage (Rectal Suppositories): 1 suppository 2 times a week for chronic proctitis during remission.

Pediatric Dosage (Rectal Suppositories): Contraindicated for children under 14 years.

Contraindications (Rectal Suppositories): Individual intolerance to components, acute anal fissures; no data on pregnancy.

Side Effects (Rectal Suppositories): Allergic reactions with overdose, local irritation.

Adjustment for Patient Body Weight: Dose adjustment is not required.

Preparation method (Rectal Suppositories): For 100 suppositories, use 25 g of 50 g of coconut oil, 15 g of cocoa butter, 10 g of beeswax. Melt the oils and wax at 40–45°C, add the extract, mix, pour into molds, cool until hardened.

Storage Conditions and Shelf Life (Rectal Suppositories): Store in a dark, cool place at 8–15°C; shelf life 6 months, after opening the package use within 1 month.

Nasal Drops — Globe Amaranth

Indications (Nasal Drops): allergic and infectious rhinitis, sinusitis, swelling of the nasal mucosa.

Standard Dosage (Nasal Drops): 2 drops in each nostril 3 times daily, course 7–10 days.

Enhanced Dosage (Nasal Drops): 3 drops 4 times daily for pronounced inflammations and chronic sinusitis, course 14 days.

Maximum Dosage (Nasal Drops): Not more than 4 drops in each nostril 4 times daily.

Preventive Dosage (Nasal Drops): 1–2 drops once daily during allergy season, course 1 month.

Pediatric Dosage (Nasal Drops): Nasal drops are contraindicated for children under 6 years.

Contraindications (Nasal Drops): Individual intolerance to components; no data on pregnancy and lactation.

Side Effects (Nasal Drops): Possible local irritation and allergic reactions with overdose.

Adjustment for Patient Body Weight: Dosage adjustment is not required.

Preparation method (Nasal Drops): For 100 ml of drops, take 5 g of dissolve in 95 ml of isotonic sodium chloride solution, add 0.1 g of preservative sodium benzoate. All components are thoroughly mixed, filtered through a sterile filter, and poured into glass bottles with a dropper. Store in a dark place.

Storage Conditions and Shelf Life (Nasal Drops): Store at 4–8°C; shelf life 1 month, after opening use within 14 days.

Ear Drops — Globe Amaranth

Indications (Ear Drops): otitis, inflammations of the external ear, itching, dryness in the ear canal.

Standard Dosage (Ear Drops): 3–4 drops 2 times daily into the ear canal, course 7–10 days.

Enhanced Dosage (Ear Drops): 4–5 drops 3 times daily for pronounced inflammations, course 14 days.

Maximum Dosage (Ear Drops): Not more than 5 drops 3 times daily.

Preventive Dosage (Ear Drops): 2 drops once daily for tendency to dryness and irritation of the external ear, course 1 month.

Pediatric Dosage (Ear Drops): Contraindicated for children under 5 years.

Contraindications (Ear Drops): Perforation of the eardrum, individual intolerance to components.

Side Effects (Ear Drops): Local allergic reactions with overdose.

Adjustment for Patient Body Weight: Dosage adjustment is not required.

Preparation method (Ear Drops): For 100 ml of drops, use 5 g of Globe Amaranth extract, dissolve in 95 ml of cold-pressed coconut oil, mix thoroughly, filter, and package in dark bottles with a dropper.

Storage Conditions and Shelf Life (Ear Drops): Store in a cool, dark place at 15–25°C; shelf life 6 months, after opening use within 3 months.

Ointment — Globe Amaranth

Indications (Ointment): dermatitis, eczema, inflammatory skin diseases, ulcerative lesions.

Standard Dosage (Ointment): Apply Globe Amaranth Ointment in a thin layer 2 times daily to affected skin areas.

Enhanced Dosage (Ointment): Apply Globe Amaranth Ointment 3 times daily for severe forms of dermatitis and ulcerative lesions.

Maximum Dosage (Ointment): Use no more than 20 g of ointment per day.

Preventive Dosage (Ointment): Apply once daily for tendency to chronic dermatoses and dry skin during remission periods.

Pediatric Dosage (Ointment): Ointment is approved for children from 3 years, apply once daily, weight from 15 kg.

Contraindications (Ointment): Individual intolerance to components; no data on contraindications during pregnancy and lactation.

Side Effects (Ointment): Possible allergic reactions with overdose.

Adjustment for Patient Body Weight: Dosage adjustment is not required; local application.

Preparation method (Ointment): For 100 g of ointment, use 20 g of 60 g of virgin cold-pressed coconut oil, 20 g of beeswax. Melt the coconut oil and wax in a water bath at 40–45°C, add the extract, mix until homogeneous, cool, and package.

Storage Conditions and Shelf Life (Ointment): Store in a cool, dark place at 15–25°C; shelf life 12 months, after opening use within 6 months.

Cream — Globe Amaranth

Indications (Cream): dry skin, dermatitis, inflammatory skin processes.

Standard Dosage (Cream): Apply Globe Amaranth Cream to the skin 2 times daily in a thin layer.

Enhanced Dosage (Cream): Apply 3 times daily for pronounced dryness and skin inflammation.

Maximum Dosage (Cream): Not more than 30 g of cream per day.

Preventive Dosage (Cream): Apply once daily for chronic dermatoses and predisposition to dry skin.

Pediatric Dosage (Cream): Approved from 3 years, apply once daily, weight from 15 kg.

Contraindications (Cream): Individual intolerance to components; no data on contraindications during pregnancy and lactation.

Side Effects (Cream): Possible local allergic reactions with overdose.

Adjustment for Patient Body Weight: Dose adjustment is not required; local application.

Preparation method (Cream): For 100 g of cream, use 15 g of Globe Amaranth extract, 50 g of coconut oil, 25 g of shea butter, 10 g of plant-derived emulsifier. All ingredients are mixed at 40°C until a homogeneous creamy mass, packaged in tubes or jars.

Storage Conditions and Shelf Life (Cream): Store in a dark place at 15–25°C; shelf life 12 months, after opening use within 6 months.

Cosmetic Serum — Globe Amaranth

Indications (Cosmetic Serum): skin hydration, improving elasticity, anti-aging therapy, relieving skin inflammations.

Standard Dosage (Cosmetic Serum): Apply Globe Amaranth Cosmetic Serum to cleansed facial skin once daily in the evening.

Enhanced Dosage (Cosmetic Serum): Apply 2 times daily for pronounced signs of skin dryness and inflammation, course up to 1 month.

Maximum Dosage (Cosmetic Serum): Not recommended to exceed application 2 times daily.

Preventive Dosage (Cosmetic Serum): Use once daily during dry skin season and after aggressive external exposures.

Pediatric Dosage (Cosmetic Serum): Not recommended for children under 14 years.

Contraindications (Cosmetic Serum): Individual intolerance to components; no data on contraindications during pregnancy and lactation.

Side Effects (Cosmetic Serum): Possible allergic reactions with overdose.

Adjustment for Patient Body Weight: Dose adjustment is not required; local application.

Preparation method (Cosmetic Serum): For 100 ml of serum, take 5 g of Globe Amaranth extract, 80 ml of distilled water, 10 ml of aloe vera gel, 5 ml of virgin cold-pressed coconut oil. All components are mixed until homogeneous, poured into sterile bottles with a dispenser.

Storage Conditions and Shelf Life (Cosmetic Serum): Store in the refrigerator at 4–8°C; shelf life 6 months, after opening use within 3 months.

Toxicity and Biosafety of Globe Amaranth

Studies show that the LD50 of the oral extract of Globe Amaranth in mice exceeds 5000 mg/kg, which corresponds to low acute toxicity. Topical application does not cause significant skin irritation or sensitization. Data on long-term toxicity are limited, but when using recommended doses and forms, the preparation is considered safe. It is recommended to avoid using concentrated forms without supervision and in individuals with individual sensitivity.

Reference: https://www.ncbi.nlm.nih.gov/p...

Pharmacodynamics of Globe Amaranth

The pharmacodynamic properties of Globe Amaranth are due to the complex action of biologically active components, among which flavonoids, saponins, phenolic acids, alkaloids, and other polyphenolic compounds dominate. These substances have pronounced antioxidant and anti-inflammatory effects aimed at reducing the production of pro-inflammatory cytokines and stabilizing cell membranes, leading to a reduction in local inflammation and oxidative stress. By modulating the activity of key enzymes and signaling pathways such as cyclooxygenase and lipoxygenase, plant extracts contribute to the normalization of cellular homeostasis and regulation of the immune response.

The effect on the nervous system is manifested by a moderate sedative and anxiolytic effect, likely through interaction with GABAergic system receptors and regulation of neurotransmitters. These properties contribute to reducing nervous tension and improving general condition in functional disorders of the central nervous system.

Immunomodulatory action is realized through stimulation of macrophage and lymphocyte activity, as well as through balancing the cytokine profile, which increases the body's resistance to infectious and inflammatory processes at the systemic level. Influence on the endocrine system is noted in the ability of plant components to positively affect metabolic processes, including carbohydrate metabolism, by regulating insulin-like factors and receptors.

Regarding the gastrointestinal tract, active substances contribute to improved motility and reduced inflammation of the mucous membrane, which is due to protective and antiulcer effects. Stimulation of regenerative processes at the epithelial level has also been identified.

Local action on the skin is manifested by antioxidant, anti-inflammatory, and moisturizing activity, which contributes to improving skin structure, reducing inflammation manifestations, and accelerating healing of damage. Active components interact with collagen and elastin, promoting increased skin elasticity and reducing signs of photoaging.

Thus, the pharmacodynamics of Globe Amaranth covers several physiological systems and biochemical targets, providing a wide range of therapeutic effects at systemic and local levels. These properties make the plant promising for the development of complex phytopreparations with immunomodulatory, anti-inflammatory, antioxidant, and neuroprotective action.

References: https://www.ncbi.nlm.nih.gov/p... https://www.sciencedirect.com/... https://onlinelibrary.wiley.co...

Pharmacokinetics of Globe Amaranth

Absorption of biologically active substances of Globe Amaranth upon oral administration occurs primarily in the upper gastrointestinal tract, where flavonoids and polyphenols pass through the mucous membrane via passive diffusion and active transport. Metabolism includes phase I and phase II reactions in the liver, where compounds undergo hydroxylation, conjugation with glucuronic and sulfuric acids, increasing their solubility and promoting excretion.

Distribution of active components is characterized by their ability to penetrate tissues with high blood flow, including the liver, kidneys, skin, and nervous system tissues. Some metabolites can accumulate in tissues, exerting local action and maintaining a prolonged pharmacological effect.

Excretion occurs primarily with urine and bile, where conjugated metabolites undergo excretion through renal tubules and the intestine. In some cases, partial reabsorption in the kidneys is possible, which may prolong the duration of action of the substances.

The transdermal route of administration (e.g., in the form of ointments and creams) provides local exposure with minimal systemic absorption, reducing the risk of side effects and allowing concentration of action on the affected area. When using nasal and ear drops, absorption can occur through mucous membranes with a rapid onset of action at the local level.

Interaction with intestinal microflora is assumed in the context of the metabolism of polyphenolic compounds, which can be modified by bacterial enzymes, affecting their bioavailability and pharmacological activity.

In summary, the pharmacokinetics of Globe Amaranth correspond to the characteristics of plant flavonoids and polyphenols with pronounced metabolism in the liver and excretion through the kidneys and intestine. This requires consideration of individual patient characteristics, especially in cases of impaired liver and kidney function.

References: https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/... https://link.springer.com/arti...

Mechanisms of Action and Scientific Rationale — Globe Amaranth

The main biological effects of Globe Amaranth are associated with the complex interaction of diverse biologically active components, including flavonoids, saponins, phenolic acids, and alkaloids. Flavonoids, in particular, demonstrate the ability to inhibit the enzyme systems of cyclooxygenase (COX) and lipoxygenase (LOX), leading to reduced synthesis of pro-inflammatory prostaglandins and leukotrienes, exerting an anti-inflammatory effect. These substances also affect the NF-κB signaling cascade, blocking factor translocation into the nucleus and thereby reducing the expression of genes responsible for the inflammatory response. Additionally, flavonoids regulate the activity of MAPK and JAK/STAT pathways, influencing the cell cycle and proliferation of immune cells.

Saponins contribute to the stabilization of cell membranes and modulation of the immune response by activating macrophages and neutrophils, stimulating cytokine production, and increasing phagocytic activity. Alkaloids in the plant composition may interact with central nervous system receptors, including serotonin and dopamine receptors, explaining sedative and anxiolytic properties. Modulation of the cholinergic system through inhibition of acetylcholinesterase (AChE) is also observed, contributing to neuroprotective effects.

Polyphenolic compounds participate in reducing oxidative stress by neutralizing free radicals and activating endogenous antioxidant enzymes such as superoxide dismutase and catalase. This exerts a protective effect on the vascular endothelium and contributes to improved microcirculation.

Action on endocrine regulatory systems is manifested in the modulation of signaling pathways involved in carbohydrate and lipid metabolism through influence on insulin and glucocorticoid receptors, potentially affecting homeostasis and energy metabolism.

Thus, Globe Amaranth affects multiple biochemical targets and signaling cascades, providing complex systemic and local influence on physiological processes, including immune response, inflammation, neuroprotection, and metabolism.

References: https://pubmed.ncbi.nlm.nih.go... https://www.sciencedirect.com/... https://www.ncbi.nlm.nih.gov/p...

Synergy of Globe Amaranth

Scientific research demonstrates that Globe Amaranth exhibits pronounced pharmacological synergy when combined with other plants rich in flavonoids and saponins, such as Camellia sinensis (green tea) and Withania somnifera (ashwagandha). Combined use enhances antioxidant activity due to additive neutralizing action of free radicals and potentiates the anti-inflammatory effect through joint suppression of NF-κB activity and enhanced regulation of the cytokine profile.

In combination with plants possessing immunomodulatory properties, for example, Echinacea purpurea, Globe Amaranth contributes to enhanced activation of macrophages and lymphocytes, leading to a more pronounced immunomodulatory effect. These interactions are realized through joint influence on JAK/STAT and MAPK signaling pathways, allowing coordination of cellular immunity.

Furthermore, combination with plant adaptogens, such as Rhodiola rosea, exerts a modulating influence on the nervous system, potentiating sedative and anxiolytic effects through common targets — GABAergic receptors and neurotransmitter systems.

Thus, Globe Amaranth demonstrates the ability for additive and potentiating interaction with other phyto-components, expanding the spectrum and enhancing the effectiveness of pharmacological actions, especially in the areas of antioxidant protection, anti-inflammatory, and immunomodulatory influence.

References: https://www.ncbi.nlm.nih.gov/p... https://www.sciencedirect.com/... https://pubmed.ncbi.nlm.nih.go...

Geography of Use and Folk Medicine — Globe Amaranth

Globe Amaranth is traditionally used in various regions of the world, including South and Central America, Southeast Asia, as well as parts of Africa. In Mexico and the Caribbean islands, the plant has been known since colonial times and is used in folk remedies for preparing infusions and decoctions used for general ailments and inflammatory conditions. In Thai traditional medicine, Globe Amaranth is considered a plant with calming properties and is included in recipes for improving skin condition and reducing inflammation. In Indian Ayurveda, the plant is used in complex preparations for supporting the immune system and general body strengthening.

Ethnoculturally, Globe Amaranth is associated with the folk practices of indigenous peoples of the Amazon, where it was used in the form of decoctions and infusions for washing and compresses, as well as a component of ritual drinks symbolizing strength and purification. In Central American cultures, the plant was used in healing rituals and was considered a talisman protecting from evil spirits.

In some African traditions, Globe Amaranth was consumed as juice or compresses to alleviate skin diseases and as a general tonic. Its use as an ornamental plant is widespread, further solidifying its role in cultural landscapes.

Historical sources indicate the use of Globe Amaranth in folk medicinal books and herbal guides of the 16th–17th centuries, preserved in libraries of Latin America and Europe. Archaeological findings confirm the presence of plant remains in tombs and settlements of pre-Columbian civilizations, indicating deep historical significance.

Non-medical use includes the use of Globe Amaranth flowers in purification rituals, making amulets, and aromatic fumigations. In a number of ethnic groups, the plant was considered a symbol of vital force and was used in fertility and protection rites.

Thus, Globe Amaranth possesses multifaceted ethnobotanical heritage, including medical, cultural, and ritual aspects, confirming its importance in the folk traditions of various regions.