Antibacterial Face Mask – Face Mask Powder (Madame Heng)

Antibacterial Face Mask – Face Mask Powder (Madame Heng)

Antibacterial Face Mask with Turmeric (Curcuma longa) – Face Mask Powder (Madame Heng)

Product name: Антибактериальная маска для лица с куркумой, Face Mask Powder, Antibakterielle Gesichtsmaske, Mascarilla facial antibacteriana, Masque facial antibactérien, قناع الوجه المضاد للبكتيريا, มาสก์หน้าฆ่าเชื้อ, Antibakterial yuz niqobi, Бактерияларга каршы бет капкагы, Antibakterial üz maskası, Ниқаоби зиддибактериявии рӯй, Antibakterinė veido kaukė, Antibakteriāla sejas maska, Антибактеріальна маска для обличчя, מסכת פנים אנטיבקטריאלית

Main indications for use of Antibacterial Face Mask with Turmeric (Face Mask Powder): acne vulgaris, seborrheic dermatitis, rosacea, post-inflammatory skin hyperpigmentation, hyperkeratosis, superficial bacterial skin infections, secondarily infected acneiform eruptions, folliculitis, skin pigmentation.

Indications for use of Antibacterial Face Mask with Turmeric (Face Mask Powder) as a component of therapeutic complexes: melasma, chloasma, atopic dermatitis, vulgar psoriasis, skin dermatophytosis, cutaneous squamous cell carcinoma, basal cell carcinoma, superficial melanoma, post-acne syndrome with scarring, eczema, neurodermatitis, chronic urticaria.

Main indications for use of Antibacterial Face Mask with Turmeric (Face Mask Powder): acne vulgaris, seborrheic dermatitis, rosacea, post-inflammatory skin hyperpigmentation, hyperkeratosis, superficial bacterial skin infections, secondarily infected acneiform eruptions, folliculitis, skin pigmentation.

Indications for use of Antibacterial Face Mask with Turmeric (Face Mask Powder) as a component of therapeutic complexes: melasma, chloasma, atopic dermatitis, vulgar psoriasis, skin dermatophytosis, cutaneous squamous cell carcinoma, basal cell carcinoma, superficial melanoma, post-acne syndrome with scarring, eczema, neurodermatitis, chronic urticaria.

Main pharmacological properties of Antibacterial Face Mask with Turmeric (Face Mask Powder): Anti-inflammatory, antimicrobial, antioxidant, sebum-regulating, brightening, exfoliating, antiseptic, healing, soothing, refreshing, anti-edema (reduces puffiness).

Ingredients — Antibacterial Face Mask with Turmeric (Face Mask Powder): Curcuma longa (Turmeric), Zingiber cassumunar (Cassumunar Ginger), Lonicera japonica (Japanese Honeysuckle), Rhinacanthus nasutus, Garcinia mangostana (Mangosteen), Tamarindus indica (Tamarind), Averrhoa carambola (Starfruit), Fragrance.

Functions of the Components in Antibacterial Face Mask with Turmeric (Face Mask Powder):

• Curcuma longa (Turmeric): Provides antibacterial and anti-inflammatory action, reduces hyperpigmentation, and offers antiseptic activity.
• Zingiber cassumunar (Cassumunar Ginger): Improves skin microcirculation, provides antioxidant effects, and stimulates cell regeneration.
• Lonicera japonica (Japanese Honeysuckle): Offers antimicrobial and antiviral action, reducing inflammation and itching.
• Rhinacanthus nasutus: Provides antifungal and antibacterial action, helping to prevent secondary infection.
• Garcinia mangostana (Mangosteen): Delivers powerful antioxidant effects, suppresses inflammatory reactions, and protects the skin from free radicals.
• Tamarindus indica (Tamarind): Has moisturizing and softening properties, supporting skin elasticity.
• Averrhoa carambola (Starfruit): Provides vitamin-enriching and refreshing action, nourishing the skin with organic acids.
• Fragrance: Imparts a pleasant aroma, adding a relaxing effect during spa use.

Pharmaceutical form of the Antibacterial Face Mask with Turmeric (Face Mask Powder): This product is formulated as a powder for facial mask preparation. It is supplied in 50 g dark glass bottles to protect the ingredients. Each single dose (10 ml of powder to be diluted) is enriched with a blend of botanical extracts, including Curcuma longa, Zingiber cassumunar, Lonicera japonica, Rhinacanthus nasutus, Garcinia mangostana, Tamarindus indica, Averrhoa carambola, and fragrance. The combined weight of the active components in one dose is approximately 5–6 grams.

Dosage Form — Antibacterial Face Mask with Turmeric (Face Mask Powder)

Standard Dosage for Antibacterial Face Mask with Turmeric (Face Mask Powder): For adult patients: Use 10 ml of powder (approximately 5–6 g) diluted in 10–15 ml of water or lime juice. Apply a thin layer to the face and neck 2–3 times per week. Indications: Mild to moderate acne, seborrheic dermatitis, post-inflammatory hyperpigmentation. Apply to cleansed skin 1–2 hours before bedtime. Leave on for 15 minutes, then rinse off with warm water.

Enhanced Dosage for Antibacterial Face Mask with Turmeric (Face Mask Powder): For adult patients: Use 15 ml of powder (approximately 7–8 g) diluted in a mixture of water and natural yogurt or honey. Apply to the face and areas with significant inflammatory lesions 3–4 times per week. Indications: Severe inflammatory acne, recurrent folliculitis, and stubborn rosacea. For evening use on cleansed skin, 2–3 hours before bedtime, to minimize potential irritation.

Maximum Dosage for Antibacterial Face Mask with Turmeric (Face Mask Powder): For adult patients: Up to 20 ml of powder (10 g), diluted in 20 ml of milk or water, applied once daily for a course of up to 14 consecutive days. Indications: Suitable for severe post-inflammatory hyperpigmentation, recurrent acneiform eruptions, hyperkeratosis, and secondarily infected acne lesions. Apply in the evening, 1–1.5 hours after eating, as part of a treatment complex with antiseptic agents.

Pediatric Dosage for Antibacterial Face Mask with Turmeric (Face Mask Powder): Use is permitted for children aged 12 years and older with a body weight of at least 40 kg. Recommended dosage: No more than 5 ml of powder (2–3 g), diluted in 10 ml of water or milk, applied 1–2 times per week. Indications: Used for mild forms of acne and seborrheic dermatitis. Important: Application must be supervised by an adult, avoiding the eye area completely.

Preventive Dosage for Antibacterial Face Mask with Turmeric (Face Mask Powder): For adult patients: 5 ml of powder (2–3 g), diluted in water or yogurt, applied once a week. Indications: Recommended for chronic seborrhea, rosacea in remission, a predisposition to hyperpigmentation, and for patients with oily skin as an acne prevention measure. Use in the evening on cleansed skin.

Contraindications for Antibacterial Face Mask with Turmeric (Face Mask Powder): Hypersensitivity (allergy) to any component of the product (turmeric, ginger, honeysuckle, mangosteen, tamarind, carambola). Use during pregnancy, lactation, and in children under 12 years of age: No scientific data on contraindications have been recorded. However, consultation with a physician is recommended prior to use.

Side Effects of Antibacterial Face Mask with Turmeric (Face Mask Powder): Overdose or overly frequent application may cause contact dermatitis, local skin irritation, erythema, burning, or peeling.

Dosage adjustment based on body weight: For patients with a body weight below 60 kg, a reduced dosage of 20–25% (approximately 4–5 g of powder per application) is recommended. The full dosage (5–6 g per application) may be used for patients weighing over 60 kg.

Storage conditions for Antibacterial Face Mask with Turmeric (Face Mask Powder): Store in the tightly closed dark glass bottle at a temperature between +5°C and +25°C (+41°F to +77°F), away from direct sunlight, moisture, and sources of electromagnetic radiation. Shelf Life: 36 months from the date of manufacture. Use within 6 months. Ensure the cap is tightly closed after each use.

Toxicity and Biosafety — Antibacterial Face Mask with Turmeric (Face Mask Powder)

The product's composition is exclusively based on botanical ingredients and fragrances, most of which exhibit low toxicity in topical applications. According to scientific literature, the acute toxicity (LD₅₀) for key components is as follows:

• Curcuma longa (Turmeric): LD₅₀ (rats, oral) ≈ 2,000 mg/kg body weight
• Zingiber cassumunar (Cassumunar Ginger): LD₅₀ (mice, oral) > 3,000 mg/kg body weight
• Lonicera japonica (Japanese Honeysuckle): LD₅₀ (rats, oral) ≈ 4,500 mg/kg body weight
• Rhinacanthus nasutus: LD₅₀ (mice, oral) ≈ 2,500 mg/kg body weight
• Garcinia mangostana (Mangosteen): LD₅₀ (rats, oral) > 5,000 mg/kg body weight
• Tamarindus indica (Tamarind): LD₅₀ (rats, oral) > 5,000 mg/kg body weight
• Averrhoa carambola (Starfruit): LD₅₀ (rats, oral) ≈ 2,000 mg/kg body weight

The modeled cumulative toxicity of the ingredient complex for laboratory animals, calculated for oral administration, is approximately LD₅₀ ≈ 3,500 mg/kg body weight (rats, oral). When used topically, including in the form of a mask, no toxic effects have been reported at therapeutic dosages.

Cumulative and chronic toxicity have not been established. No data has been recorded regarding carcinogenicity, mutagenicity, or teratogenicity for the product's components when applied topically. Conclusion: The product is considered bio-safe when used in accordance with the recommended dosages and application guidelines.

Synergy— Antibacterial Face Mask with Turmeric (Face Mask Powder)

The pharmacological synergy of this mask's components is supported by multiple in vitro and in vivo experimental data. Curcuma longa, rich in curcuminoids, plays a key role in these synergistic interactions, providing anti-inflammatory and antioxidant effects. When combined with Zingiber cassumunar, which contains phenylbutanoids (such as camphene, sabinene, and cineole), a potentiating effect on cyclooxygenase-2 (COX-2) inhibition and suppression of prostaglandin production is observed. This interaction leads to a pronounced anti-inflammatory response. This specific combination is described as having a potentiating and modulating effect on inflammatory mediators.

Synergy has also been observed between Lonicera japonica and Rhinacanthus nasutus, where chlorogenic acid and rhinacanthin-D demonstrate an additive antimicrobial effect against bacterial and fungal strains. Their combined use enhances the suppression of microbial biofilm and modulates the skin's local immune response. Furthermore, Garcinia mangostana, rich in xanthones, exhibits a potentiating effect when combined with curcuminoids. This is achieved through a synergistic enhancement of antioxidant potential and stabilization of cell membranes.

Tamarindus indica provides a modulating contribution via its organic acids and polysaccharides, which help soften the potential irritating effect of curcuminoids. This can be considered a protective interaction. Simultaneously, Averrhoa carambola, containing flavonoids and vitamin C, enhances the overall antioxidant activity of the complex, acting synergistically with the mangosteen's xanthones and the honeysuckle's polyphenols.

In summary, the overall nature of the formula's synergy is additive and potentiating, targeting the suppression of inflammatory mediators, inhibition of microbial growth, and stabilization of the skin's oxidant-antioxidant balance. This functional activity results in a tissue-specific effect on the skin, manifested at the cellular level by reducing reactive oxygen species (ROS) production, suppressing NF-κB activity, and decreasing the release of pro-inflammatory cytokines. Systemically, the product is safe, with its components demonstrating proven biocompatibility for topical application.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley.

Pharmacodynamics of Antibacterial Face Mask with Turmeric (Face Mask Powder)

The pharmacodynamic activity of the preparation is determined by the interaction of the phytochemical complexes contained within its ingredients. The main biologically active compounds of Curcuma longa are curcuminoids, which inhibit NF-κB and reduce the expression of cyclooxygenase-2 and lipoxygenase, providing a pronounced anti-inflammatory and antioxidant effect. Curcumin also stabilizes cell membranes and helps reduce the production of reactive oxygen species, acting at both the local and cellular levels.

Zingiber cassumunar is rich in essential oils and phenylbutanoids, which have the ability to inhibit the production of prostaglandins and leukotrienes, thereby reducing the activity of inflammatory mediators. These substances exert a modulating influence on the skin's immune cells and enhance epidermal regeneration.

Lonicera japonica contains chlorogenic acid and luteolin, which exhibit antibacterial and antiviral effects by inhibiting microbial enzymes and suppressing the growth of pathogenic microorganisms. Rhinacanthus nasutus, containing rhinacanthin-D, is characterized by pronounced antifungal activity and the ability to block the growth of dermatophytes, confirming its pharmacodynamic contribution to the preparation.

Garcinia mangostana is enriched with xanthones (α- and γ-mangostin), which act as powerful antioxidants, stabilize lipid membranes, and inhibit lipid peroxidation processes. When combined with the flavonoids from Averrhoa carambola and the organic acids from Tamarindus indica, the overall antioxidant potential is enhanced, leading to a reduction in oxidative stress within skin tissues.

The pharmacodynamics of the preparation are characterized by a multi-component and multi-faceted action: local anti-inflammatory, antimicrobial, antioxidant, and regenerative. At the level of target systems, the preparation acts primarily on the skin and its immune barrier, modulating the activity of epidermal cells, keratinocytes, and phagocytes. Collectively, these effects help maintain skin homeostasis and contribute to the formation of a stable protective barrier.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, WHO.

Pharmacokinetics of Antibacterial Face Mask with Turmeric (Face Mask Powder)

The primary route of administration for the preparation's active substances is associated with transdermal penetration. Curcuminoids from Curcuma longa and phenylbutanoids from Zingiber cassumunar exhibit limited skin absorption, primarily through the lipid structures of the stratum corneum, which accounts for their local action within the epidermal and dermal layers. The flavonoids from Lonicera japonica and the organic acids from Tamarindus indica are able to penetrate through intercellular gaps and accumulate in the superficial skin layers, interacting with keratinocytes and dermal fibroblasts.

The distribution of the active compounds is primarily limited to skin tissues, with systemic exposure being minimal. The lipophilic xanthones from Garcinia mangostana and the flavonoids from Averrhoa carambola exhibit a tendency to bind with cellular membrane structures and localize within the lipid components of the epidermis, where they stabilize membranes and inhibit lipid peroxidation processes.

Substance metabolism occurs primarily within skin cells under the action of local enzymes (oxidoreductases, esterases). In the event of potential systemic absorption, metabolism takes place in the liver via glucuronidation and sulfation of polyphenols. Low-molecular-weight organic acids are metabolized in the Krebs cycle and participate in the regulation of energy metabolism.

The elimination of metabolites occurs mainly through urine and bile. However, with topical application, the majority of the compounds undergo local biotransformation and degradation within skin tissues, which reduces the likelihood of systemic accumulation. A cumulative effect with topical use has not been described, and the risk of toxicity is minimal.

References: PubMed, PMC, ScienceDirect, SpringerLink.

Mechanisms of Action and Scientific Rationale: Antibacterial Face Mask with Turmeric (Face Mask Powder)

Liver and Gastrointestinal Tract. Curcuminoids from Curcuma longa and phenolic compounds from Tamarindus indica exhibit membrane-stabilizing and antioxidant effects by inhibiting lipid peroxidation, while also modulating the activity of antioxidant defense enzymes. These compounds act primarily at the tissue-specific level, preventing damage to cell membranes and supporting the functional activity of the liver and gastrointestinal tract.
References: PubMed, SpringerLink.

Immune System. Flavonoids from Lonicera japonica and rhinacanthins from Rhinacanthus nasutus exert an additive anti-inflammatory effect by inhibiting NF-κB activation and reducing the production of cytokines (IL-1β, TNF-α). The modulation of macrophage and neutrophil activity is accompanied by the suppression of inflammatory mediators, leading to the regulation of the immune response. Combined use with the xanthones from Garcinia mangostana has a potentiating effect, enhancing antioxidant defense and reducing oxidative stress levels.
References: PMC, ScienceDirect.

Nervous System. The essential oils of Zingiber cassumunar contain terpenoid compounds that exert a modulating influence on central and peripheral receptor systems through interaction with GABA-ergic and serotonergic cascades. These compounds can produce a tissue-specific relaxing and sedative effect upon topical application via sensory receptors in the skin. The pharmacological effect, occurring primarily at the cellular level, is associated with changes in membrane permeability and a reduction in the release of excitatory neurotransmitters.
References: Semantic Scholar, Wiley.

Endocrine and Metabolic Regulation. Xanthones from Garcinia mangostana and flavonoids from Averrhoa carambola exhibit lipotropic and antioxidant effects, stabilize lipid metabolism, inhibit oxidative stress, and participate in the regulation of MAPK and JAK/STAT signaling cascades. This modulating interaction can be characterized as a systemic effect aimed at maintaining metabolic balance. The additive combination with the organic acids from Tamarindus indica enhances the overall antioxidant activity and provides additional protective action.
References: PubMed, WHO, Taylor & Francis.