Eurycoma longifolia (Tongkat Ali / Longjack)

Eurycoma longifolia (Tongkat Ali / Longjack)

Product Name: эврикома длиннолистная, Eurycoma longifolia, Langblättrige Eurycoma, Eurycoma de hojas largas, Eurycoma à longues feuilles, يوريكوما طويل الأوراق, ตงกัตอาลี, узунбаргли эврикома, узун жалбырак эврикома, uzunyarpaq evrikoma, эврикомаи баргидароз, ilgialapė evrikoma, garalapju eirikoma, еврикома довголиста, uzunyarpaq evrikoma, אוריוקומה ארוכת עלים

Synonyms: тонгкат али, пасак бумі, малайзийский женьшень, long jack, Tongkat Ali, Longjack, Malaysian ginseng, Pasak bumi, Langblättrige Eurycoma, Langblättriger Bitterholzbaum, Eurycoma de hojas largas, Ginseng malasio, Eurycoma à longues feuilles, Ginseng malaisien, يوريكوما طويل الأوراق, جنسنغ ماليزي, ตงกัตอาลี, ปาซักบูมี

Parts Used: root, root bark, wood, leaves, fruits.

Main Indications for Eurycoma longifolia Use: erectile dysfunction, hypogonadism, decreased libido, malaria, fever, bacterial dysentery, diarrhea of infectious etiology, chronic fatigue syndrome, anemia, stress disorders, decreased physical performance.

Indications for Eurycoma longifolia Use in mixtures and complexes: type 2 diabetes mellitus, malignant neoplasms of the prostate, malignant neoplasms of the liver, malignant neoplasms of the lung, acute leukemia, gastric ulcer, duodenal ulcer, chronic inflammatory joint diseases, age-related androgen deficiencies, asthenic conditions.

Main Pharmacological Properties of Eurycoma longifolia: antioxidant, antimicrobial, antitumor, cytotoxic, antiprotozoal, antimalarial, antihyperglycemic, anti-inflammatory, analgesic, antipyretic, gastroprotective, adaptogenic, androgen-stimulating, immunomodulating.

Dosage of Pharmaceutical Forms — Eurycoma longifolia

Powder — Eurycoma longifolia

Indications (Powder): erectile dysfunction, hypogonadism, decreased libido, bacterial dysentery, chronic fatigue syndrome, anemia, stress disorders, decreased physical performance.

Standard Dosage (Powder): orally, 2 grams of powder 2 times a day, with 150 milliliters of warm water, course of 21 days.

Enhanced Dosage (Powder): orally, 3 grams of powder 2 times a day for hypogonadism, severe erectile dysfunction, chronic bacterial dysentery, severe chronic fatigue syndrome.

Maximum Dosage (Powder): orally, 3 grams of powder 3 times a day for severe hypogonadism, chronic recurrent intestinal infections, persistent forms of erectile dysfunction.

Preventive Dosage (Powder): orally, 1 gram of powder 1 time a day for 30 days, 2 times a year, for chronic stress conditions, mild anemia, in men over 45 years of age with initial stage of age-related testosterone decline.

Pediatric Dosage (Powder): not recommended for children under 12 years of age; for children over 12 years of age and body weight over 40 kilograms — 0.5 grams of powder 1 time a day, course no longer than 14 days.

Contraindications (Powder): contraindicated in case of individual intolerance, acute liver and kidney diseases, severe cardiovascular diseases; no contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Powder): in case of overdose may cause insomnia, tachycardia, irritability, headache.

Adjustment for Patient Body Weight: for body weight below 60 kilograms, reduce dosage by 25%; for body weight above 90 kilograms, increase dosage by 25%.

Preparation method (Powder): use dry plant roots, clean from impurities, cut into pieces 5–7 centimeters long, dry at 40 °C in a drying oven to a moisture content not exceeding 10%, grind in a mill to a powder state, sift through a sieve with a mesh size of 0.5 millimeters. To prepare 100 grams of product, 100 grams of dry root are required. Package in an airtight dark glass container.

Storage Conditions and Shelf Life: store in a dry, light-protected place away from sources of electromagnetic radiation at a temperature of 15–25 °C, shelf life — 24 months; after opening the package, use within 60 days.

Dry Extract — Eurycoma longifolia

Indications (Dry Extract): erectile dysfunction, hypogonadism, decreased libido, malaria, bacterial dysentery, chronic fatigue syndrome, anemia, stress disorders.

Standard Dosage (Dry Extract): orally, 200 milligrams of dry extract (calculated on raw root 5:1) 1 time a day, course of 21 days.

Enhanced Dosage (Dry Extract): orally, 200 milligrams of dry extract 2 times a day for severe hypogonadism, severe erectile dysfunction, malaria.

Maximum Dosage (Dry Extract): orally, 300 milligrams of dry extract 2 times a day for resistant forms of hypogonadism, persistent forms of erectile dysfunction.

Preventive Dosage (Dry Extract): orally, 100 milligrams of dry extract 1 time a day for 30 days, 1–2 times a year, for chronic fatigue, mild anemia, age-related testosterone decline.

Pediatric Dosage (Dry Extract): not recommended for children under 12 years of age; for children over 12 years of age and body weight over 40 kilograms — 50 milligrams of dry extract 1 time a day, course no longer than 14 days.

Contraindications (Dry Extract): contraindicated in case of individual intolerance, acute liver and kidney diseases, severe cardiovascular diseases; no contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Dry Extract): in case of overdose may cause insomnia, tachycardia, irritability, headache, increased blood pressure.

Adjustment for Patient Body Weight: for body weight below 60 kilograms, reduce dosage by 25%; for body weight above 90 kilograms, increase dosage by 25%.

Preparation method (Dry Extract): ground dry root is poured with 70% ethanol in a ratio of 1:10, infused for 72 hours at room temperature, filtered, then evaporated in a water bath at a temperature not exceeding 50 °C to a thick extract, then dried in a drying oven at 40 °C until a dry extract is obtained. The organic solvent (ethanol) is used only for extraction and is completely removed; removal control — complete disappearance of odor, residual content not higher than pharmacopoeial standards (less than 500 ppm).

Storage Conditions and Shelf Life: store in a dry, light-protected place away from sources of electromagnetic radiation at a temperature of 15–25 °C, shelf life — 24 months; after opening the package, use within 90 days.

Tincture — Eurycoma longifolia

Indications (Tincture): erectile dysfunction, hypogonadism, decreased libido, malaria, bacterial dysentery, chronic fatigue syndrome, anemia, stress disorders, decreased physical performance.

Standard Dosage (Tincture): orally, 5 milliliters of alcohol tincture 2 times a day, with 100 milliliters of water, course of 21 days.

Enhanced Dosage (Tincture): orally, 7 milliliters of alcohol tincture 2 times a day for severe hypogonadism, severe erectile dysfunction, pronounced chronic fatigue syndrome.

Maximum Dosage (Tincture): orally, 10 milliliters of alcohol tincture 2 times a day for persistent forms of erectile dysfunction, chronic recurrent intestinal infections.

Preventive Dosage (Tincture): orally, 3 milliliters of alcohol tincture 1 time a day for 30 days, 2 times a year, for chronic fatigue, mild anemia, age-related testosterone decline in men over 45 years of age.

Pediatric Dosage (Tincture): not recommended for children under 18 years of age.

Contraindications (Tincture): contraindicated in case of individual intolerance, alcohol dependence, severe liver diseases, severe cardiovascular diseases; no contraindication data scientifically registered for pregnancy, lactation, and children.

Side Effects (Tincture): in case of overdose may cause insomnia, tachycardia, irritability, headache, dyspeptic disorders.

Adjustment for Patient Body Weight: for body weight below 60 kilograms, reduce dosage by 25%; for body weight above 90 kilograms, increase dosage by 25%.

Preparation method (Tincture): pour 500 milliliters of 40% ethyl alcohol over 100 grams of dry ground root, infuse for 14 days at room temperature in a dark place, shaking daily, then filter. The organic solvent (ethanol) is used only for extraction, is preserved in the finished product at the original concentration, used exclusively for internal use while observing the dosage.

Storage Conditions and Shelf Life: store in a dark place at a temperature of 15–25 °C, in a tightly closed dark glass container, shelf life — 24 months; after opening, use within 90 days.

Oil Infusion — Eurycoma longifolia

Indications (Oil Infusion): erectile dysfunction, hypogonadism, decreased libido, chronic fatigue syndrome, myalgia of inflammatory origin, arthralgia, neuralgia, decreased physical performance.

Standard Dosage (Oil Infusion): externally, rub 5 milliliters of oil infusion 1–2 times a day on the muscle or joint area, course of 21 days.

Enhanced Dosage (Oil Infusion): externally, rub 7 milliliters of oil infusion 2 times a day for pronounced pain syndromes in muscles or joints, for severe forms of erectile dysfunction as an adjuvant.

Maximum Dosage (Oil Infusion): externally, rub 10 milliliters of oil infusion 2 times a day for acute pain syndrome in muscles or joints, severe hypogonadism (as part of combination therapy).

Preventive Dosage (Oil Infusion): externally, 3 milliliters of oil infusion 1 time a day, in 14-day courses 3–4 times a year, for chronic muscle and joint pain, in men over 45 years of age with moderate decrease in physical performance.

Pediatric Dosage (Oil Infusion): externally, for children over 12 years of age and body weight over 40 kilograms — 1 milliliter of oil infusion 1 time a day, in the absence of skin damage.

Contraindications (Oil Infusion): contraindicated in case of individual intolerance, skin damage at the application site, acute dermatoses; no contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Oil Infusion): in case of overdose may cause local skin irritation, redness, itching.

Adjustment for Patient Body Weight: dosage adjustment for external use depending on body weight is not required.

Preparation method (Oil Infusion): pour 250 milliliters of coconut oil over 50 grams of dry ground root, keep in a water bath at 45 °C for 6 hours, stirring periodically, then cool and filter through cheesecloth. Package in a dark glass bottle.

Storage Conditions and Shelf Life: store in a tightly closed dark glass container, at a temperature of 8–15 °C, protected from light and heat sources, shelf life — 12 months; after opening, use within 60 days.

Vaginal Suppository — Eurycoma longifolia

Indications (Vaginal Suppository): bacterial vaginitis, candidal vaginitis, atrophic vaginitis, cervicitis of bacterial etiology, mild cervical dysplasia, chronic vaginal itching of inflammatory origin.

Standard Dosage (Vaginal Suppository): 1 suppository weighing 3 grams vaginally 1 time a day at night, course of 10 days.

Enhanced Dosage (Vaginal Suppository): 1 suppository weighing 3 grams vaginally 2 times a day for pronounced inflammatory processes, candidiasis, bacterial vaginitis with profuse discharge.

Maximum Dosage (Vaginal Suppository): 1 suppository weighing 4 grams vaginally 2 times a day for severe forms of candidiasis and bacterial vaginitis, in the absence of contraindications and under medical supervision.

Preventive Dosage (Vaginal Suppository): 1 suppository weighing 2.5 grams vaginally 1 time a day, course of 7 days, 2 times a year, for chronic recurrent vaginitis, in perimenopausal women with mucosal dryness.

Pediatric Dosage (Vaginal Suppository): not used in children and adolescents under 18 years of age.

Contraindications (Vaginal Suppository): contraindicated in case of individual intolerance, acute genital bleeding, suspected malignant tumors of the pelvic organs; no contraindication data scientifically registered for pregnancy and lactation.

Side Effects (Vaginal Suppository): in case of overdose may cause burning, itching, irritation of the vaginal mucosa.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Vaginal Suppository): for 100 grams of product: 20 grams of dry extract of eurycoma root, 80 grams of cocoa butter. Melt the cocoa butter in a water bath at a temperature of 35–37 °C, add the dry extract, mix thoroughly until a homogeneous mass is obtained, pour into molds, cool at 4 °C until completely solidified.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of 4–8 °C, in a light-protected place, shelf life — 12 months; after opening the package, use within 14 days.

Rectal Suppository — Eurycoma longifolia

Indications (Rectal Suppository): chronic prostatitis of bacterial etiology, benign prostatic hyperplasia of initial stage, chronic hemorrhoids, anal fissures, proctitis of bacterial etiology, chronic fatigue syndrome with concomitant inflammatory diseases of the pelvis.

Standard Dosage (Rectal Suppository): 1 suppository weighing 3 grams rectally 1 time a day at night, course of 10–14 days.

Enhanced Dosage (Rectal Suppository): 1 suppository weighing 3 grams rectally 2 times a day for pronounced inflammatory processes of the prostate and rectum.

Maximum Dosage (Rectal Suppository): 1 suppository weighing 4 grams rectally 2 times a day for severe forms of chronic prostatitis and proctitis, under medical supervision.

Preventive Dosage (Rectal Suppository): 1 suppository weighing 2.5 grams rectally 1 time a day, course of 7 days, 2–3 times a year, for chronic prostatitis in remission and a tendency to exacerbations.

Pediatric Dosage (Rectal Suppository): not used in children and adolescents under 18 years of age.

Contraindications (Rectal Suppository): contraindicated in case of individual intolerance, acute rectal bleeding, malignant tumors of the rectum; no contraindication data scientifically registered for pregnancy and lactation.

Side Effects (Rectal Suppository): in case of overdose may cause irritation of the rectal mucosa, itching, burning.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Rectal Suppository): for 100 grams of product: 20 grams of dry extract of eurycoma root, 80 grams of cocoa butter. Melt the cocoa butter in a water bath at a temperature of 35–37 °C, add the dry extract, mix thoroughly, pour into molds, cool at 4 °C until completely solidified.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of 4–8 °C, in a light-protected place, shelf life — 12 months; after opening the package, use within 14 days.

Nasal Drops — Eurycoma longifolia

Indications (Nasal Drops): allergic rhinitis, bacterial rhinitis, acute sinusitis, chronic sinusitis in remission, acute rhinopharyngitis, recovery period after viral infections of the upper respiratory tract.

Standard Dosage (Nasal Drops): 2 drops in each nostril 3 times a day, course of 7–10 days.

Enhanced Dosage (Nasal Drops): 3 drops in each nostril 3 times a day for bacterial rhinitis and acute sinusitis.

Maximum Dosage (Nasal Drops): 4 drops in each nostril 3 times a day for severe forms of bacterial rhinitis and acute sinusitis, under medical supervision.

Preventive Dosage (Nasal Drops): 1 drop in each nostril 2 times a day for 14 days, 2–3 times a year, for chronic rhinitis and a tendency to exacerbations.

Pediatric Dosage (Nasal Drops): for children over 6 years of age — 1 drop in each nostril 2 times a day, course up to 7 days.

Contraindications (Nasal Drops): contraindicated in case of individual intolerance, pronounced dryness of the nasal mucosa, nosebleeds; no contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Nasal Drops): in case of overdose may cause burning, sneezing, dryness of the mucosa.

Adjustment for Patient Body Weight: for body weight below 30 kilograms, reduce dosage by 50%.

Preparation method (Nasal Drops): for 100 milliliters: dissolve 10 grams of dry extract of eurycoma root in 90 milliliters of 0.9% sodium chloride solution previously heated to 35 °C, stir until completely dissolved, filter through a sterile 0.22 μm filter, dispense into sterile dropper bottles.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of 4–8 °C, shelf life — 30 days; after opening, use within 7 days.

Ear Drops — Eurycoma longifolia

Indications (Ear Drops): acute external otitis of bacterial etiology, chronic external otitis, otomycosis, cerumen impaction (as part of combination therapy), itching of the external auditory canal of inflammatory origin.

Standard Dosage (Ear Drops): 3 drops into the external auditory canal 2 times a day, course of 7–10 days.

Enhanced Dosage (Ear Drops): 4 drops 2 times a day for acute bacterial external otitis and otomycosis.

Maximum Dosage (Ear Drops): 5 drops 2 times a day for severe forms of bacterial external otitis, under the supervision of an ENT doctor.

Preventive Dosage (Ear Drops): 2 drops 1 time a day for 5 days after swimming in open water, for the prevention of external otitis.

Pediatric Dosage (Ear Drops): for children over 6 years of age — 1–2 drops 2 times a day, course up to 5 days.

Contraindications (Ear Drops): contraindicated in case of individual intolerance, perforation of the eardrum, purulent discharge from the ear without a doctor's prescription; no contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Ear Drops): in case of overdose may cause burning, itching, irritation of the ear canal skin.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Ear Drops): for 100 milliliters: dissolve 15 grams of dry extract of eurycoma root in 85 milliliters of coconut oil heated to 40 °C, mix thoroughly, filter through sterile cheesecloth, dispense into sterile dropper bottles.

Storage Conditions and Shelf Life: store in a tightly closed dark glass container, at a temperature of 8–15 °C, protected from light, shelf life — 6 months; after opening, use within 14 days.

Lotion — Eurycoma longifolia

Indications (Lotion): seborrheic dermatitis, folliculitis, acne vulgaris, post-acne with hyperpigmentation, skin mycosis, skin itching of inflammatory origin, hypotrichosis (slowed hair growth), initial stage androgenetic alopecia.

Standard Dosage (Lotion): externally, apply 3 milliliters of lotion to affected skin areas 2 times a day, course of 21 days.

Enhanced Dosage (Lotion): externally, apply 5 milliliters of lotion 2 times a day for pronounced folliculitis, active phase of acne, androgenetic alopecia.

Maximum Dosage (Lotion): externally, apply 7 milliliters of lotion 2 times a day for extensive skin lesions and pronounced alopecia, under the supervision of a dermatologist.

Preventive Dosage (Lotion): externally, 2 milliliters of lotion 1 time a day, course of 14 days, 2–3 times a year, for a tendency to seasonal hair loss or recurrence of seborrheic dermatitis.

Pediatric Dosage (Lotion): for children over 12 years of age — 1 milliliter of lotion 1 time a day, in the absence of skin damage.

Contraindications (Lotion): contraindicated in case of individual intolerance, acute purulent skin lesions, trophic ulcers, open wounds; no contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Lotion): in case of overdose may cause skin irritation, dryness, itching, peeling.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Lotion): for 100 milliliters: dissolve 10 grams of dry extract of eurycoma root in 40 milliliters of 40% ethanol (for extraction), keep for 48 hours at 25 °C, filter, add 50 milliliters of distilled water and 5 milliliters of glycerin, mix until homogeneous. Ethanol is used only as an extractant and is removed by evaporation in a water bath at a temperature not exceeding 50 °C until the odor completely disappears, residual content — no more than 500 ppm.

Storage Conditions and Shelf Life: store in a tightly closed dark glass container, at a temperature of 8–15 °C, protected from light, shelf life — 6 months; after opening, use within 30 days.

Cream — Eurycoma longifolia

Indications (Cream): acne vulgaris, post-acne with hyperpigmentation, seborrheic dermatitis, eczema, psoriasis in remission, dermatomycosis, skin itching of inflammatory origin, arthralgia, myalgia of inflammatory origin.

Standard Dosage (Cream): externally, apply a thin layer of 2–3 grams of cream to affected areas 2 times a day, course of 14–21 days.

Enhanced Dosage (Cream): externally, apply 3–4 grams of cream 3 times a day for pronounced inflammation or pain syndrome in muscles and joints.

Maximum Dosage (Cream): externally, apply 5 grams of cream 3 times a day for severe skin lesions or pronounced pain in muscles and joints, under the supervision of a specialist.

Preventive Dosage (Cream): externally, 1–2 grams of cream 1 time a day, course of 10–14 days, 2–3 times a year, for a tendency to seasonal exacerbations of seborrhea, dermatomycosis or joint pain.

Pediatric Dosage (Cream): for children over 6 years of age — 0.5–1 gram of cream 1 time a day, in the absence of skin damage.

Contraindications (Cream): contraindicated in case of individual intolerance, acute purulent skin lesions, open wounds; no contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Cream): in case of overdose may cause redness, itching, skin irritation.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Cream): for 100 grams: 10 grams of dry extract of eurycoma, 60 grams of coconut oil, 20 grams of beeswax, 10 grams of distilled water. Melt the coconut oil and beeswax in a water bath at 50 °C, add the dry extract, mix thoroughly, add water in a thin stream, continuing to stir until emulsified, cool at room temperature, package in dark jars.

Storage Conditions and Shelf Life: store in a tightly closed dark glass container, at a temperature of 8–15 °C, protected from light, shelf life — 12 months; after opening, use within 60 days.

Massage Cream — Eurycoma longifolia

Indications (Massage Cream): myalgia of inflammatory origin, arthralgia, initial stage osteoarthritis, radiculopathy, neuralgia, muscle fatigue after physical exertion, chronic prostatitis (external use in the perineal projection).

Standard Dosage (Massage Cream): externally, apply 3–4 grams of massage cream to the affected area, massage for 10–15 minutes 1–2 times a day, course of 14–21 days.

Enhanced Dosage (Massage Cream): externally, apply 5 grams of massage cream 2 times a day for pronounced pain syndrome or chronic joint inflammation.

Maximum Dosage (Massage Cream): externally, apply 7 grams of massage cream 2 times a day for severe forms of myalgia or radiculopathy, under medical supervision.

Preventive Dosage (Massage Cream): externally, 2 grams of massage cream 1 time a day, course of 10–14 days, 2–3 times a year, for the prevention of muscle pain in athletes and individuals with increased physical activity.

Pediatric Dosage (Massage Cream): for children over 12 years of age — 1–2 grams of massage cream 1 time a day, in the absence of skin damage.

Contraindications (Massage Cream): contraindicated in case of individual intolerance, acute dermatoses, skin damage at the application site; no contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Massage Cream): in case of overdose may cause skin irritation, itching, redness.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Massage Cream): for 100 grams: 10 grams of dry extract of eurycoma, 55 grams of coconut oil, 25 grams of shea butter, 10 grams of beeswax. Melt the oils and wax in a water bath at 50 °C, add the dry extract, mix thoroughly, cool to 35 °C, package in dark jars.

Storage Conditions and Shelf Life: store in a tightly closed dark glass container, at a temperature of 8–15 °C, protected from light, shelf life — 12 months; after opening, use within 60 days.

Essence — Eurycoma longifolia

Indications (Essence): acne vulgaris, post-acne with hyperpigmentation, skin photoaging, hyperpigmentation, seborrheic dermatitis, skin with signs of decreased elasticity, slowed hair growth.

Standard Dosage (Essence): externally, apply 2 milliliters of essence to cleansed facial skin or scalp 1–2 times a day, course of 30 days.

Enhanced Dosage (Essence): externally, apply 3 milliliters of essence 2 times a day for pronounced hyperpigmentation or active hair loss.

Maximum Dosage (Essence): externally, apply 4 milliliters of essence 2 times a day for severe forms of post-acne, photoaging or intense alopecia, under the supervision of a dermatologist.

Preventive Dosage (Essence): externally, 1 milliliter of essence 1 time a day, course of 14 days, 2–3 times a year, for a tendency to seasonal hair loss or skin photoaging.

Pediatric Dosage (Essence): for children over 12 years of age — 0.5–1 milliliter of essence 1 time a day, in the absence of skin damage.

Contraindications (Essence): contraindicated in case of individual intolerance, acute inflammatory skin diseases, skin damage; no contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Essence): in case of overdose may cause irritation, itching, peeling of the skin.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Essence): for 100 milliliters: 5 grams of dry extract of eurycoma, 10 milliliters of glycerin, 85 milliliters of distilled water. Dissolve the extract in glycerin, add water, mix thoroughly, filter through a sterile 0.22 μm filter, dispense into dropper bottles.

Storage Conditions and Shelf Life: store in a refrigerator at a temperature of 4–8 °C, shelf life — 6 months; after opening, use within 30 days.

Mask — Eurycoma longifolia

Indications (Mask): acne vulgaris, seborrheic dermatitis, hyperpigmentation, skin photoaging, decreased skin elasticity, inflammatory elements of post-acne, oily seborrheic skin.

Standard Dosage (Mask): externally, apply 10–12 grams of mask to cleansed facial or body skin, leave for 20 minutes, rinse with warm water, 2 times a week, course of 30 days.

Enhanced Dosage (Mask): externally, apply 15 grams of mask for 20 minutes 3 times a week for pronounced hyperpigmentation, oily skin with multiple inflammatory elements.

Maximum Dosage (Mask): externally, apply 20 grams of mask for 30 minutes 3 times a week for severe forms of acne or pronounced hyperpigmentation, under the supervision of a dermatologist.

Preventive Dosage (Mask): externally, 8–10 grams of mask 1 time a week, course of 2 months, 2 times a year, for a tendency to seasonal deterioration of skin condition.

Pediatric Dosage (Mask): for children over 12 years of age — 5–7 grams of mask 1 time a week, course up to 1 month.

Contraindications (Mask): contraindicated in case of individual intolerance, acute purulent skin lesions, open wounds; no contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Mask): in case of overdose may cause dryness, irritation, redness of the skin.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Mask): for 100 grams: 10 grams of dry powder of eurycoma root, 40 grams of cosmetic white clay, 40 milliliters of distilled water, 10 milliliters of coconut oil. Mix the powder and clay, add water and coconut oil, mix thoroughly until a paste-like consistency is obtained, package in tubes or jars.

Storage Conditions and Shelf Life: store in a tightly closed container at a temperature of 8–15 °C, protected from light, shelf life — 6 months; after opening, use within 30 days.

Emulsion Foundation — Eurycoma longifolia

Indications (Emulsion Foundation): skin photoaging, hyperpigmentation, post-acne with residual scars, skin with signs of dehydration, tendency to inflammatory elements, prevention of skin aging in patients with increased ultraviolet exposure.

Standard Dosage (Emulsion Foundation): externally, apply 1–2 grams of foundation to facial skin in an even layer 1 time a day, course of 30 days.

Enhanced Dosage (Emulsion Foundation): externally, apply 2–3 grams of foundation 2 times a day for pronounced hyperpigmentation or active photoaging.

Maximum Dosage (Emulsion Foundation): externally, apply 3–4 grams of foundation 2 times a day for severe age-related skin changes, under the supervision of a cosmetologist.

Preventive Dosage (Emulsion Foundation): externally, 1 gram of foundation 1 time a day, course of 2 months, 2 times a year, in patients at increased risk of photoaging.

Pediatric Dosage (Emulsion Foundation): not used in children under 12 years of age.

Contraindications (Emulsion Foundation): contraindicated in case of individual intolerance, acute inflammatory skin diseases, open wounds; no contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Emulsion Foundation): in case of overdose may cause redness, skin irritation, allergic rashes.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Emulsion Foundation): for 100 grams: 10 grams of dry extract of eurycoma, 60 grams of coconut oil, 15 grams of beeswax, 10 milliliters of distilled water, 5 grams of mineral pigments. Melt the oil and wax in a water bath at 50 °C, add the extract and pigments, mix, add water in a thin stream, continuing to stir until a homogeneous consistency is obtained, cool, package in tubes.

Storage Conditions and Shelf Life: store at a temperature of 8–15 °C, in a light-protected place, shelf life — 12 months; after opening, use within 60 days.

Ointment — Eurycoma longifolia

Indications (Ointment): acne vulgaris, dermatomycosis, seborrheic dermatitis, psoriasis in remission, eczema, arthralgia, myalgia of inflammatory origin, radiculopathy, neuralgia.

Standard Dosage (Ointment): externally, apply a thin layer of 2–3 grams of ointment to affected areas 2 times a day, course of 14–21 days.

Enhanced Dosage (Ointment): externally, apply 4–5 grams of ointment 2–3 times a day for pronounced inflammatory or pain manifestations.

Maximum Dosage (Ointment): externally, apply 6 grams of ointment 3 times a day for severe skin lesions or intense pain in joints and muscles, under medical supervision.

Preventive Dosage (Ointment): externally, 1–2 grams of ointment 1 time a day, course of 10–14 days, 2–3 times a year, for the prevention of seasonal exacerbations of seborrhea, arthralgia or myalgia.

Pediatric Dosage (Ointment): for children over 6 years of age — 0.5–1 gram of ointment 1 time a day, in the absence of skin damage.

Contraindications (Ointment): contraindicated in case of individual intolerance, acute purulent skin lesions, trophic ulcers, open wounds; no contraindication data scientifically registered for pregnancy, lactation, and children under 6 years of age.

Side Effects (Ointment): in case of overdose may cause redness, itching, peeling, skin irritation.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Ointment): for 100 grams: 15 grams of dry extract of eurycoma, 70 grams of coconut oil, 15 grams of beeswax. Melt the oil and wax in a water bath at 50 °C, add the extract, mix until homogeneous, cool to 30 °C, package in dark glass jars.

Storage Conditions and Shelf Life: store in a tightly closed dark glass container, at a temperature of 8–15 °C, protected from light, shelf life — 12 months; after opening, use within 60 days.

Balm — Eurycoma longifolia

Indications (Balm): myalgia of inflammatory origin, arthralgia, radiculopathy, neuralgia, osteoarthritis, chronic fatigue syndrome with muscle pain, soft tissue bruises, joint swelling.

Standard Dosage (Balm): externally, rub 2–3 grams of balm on the affected area 2 times a day, course of 14–21 days.

Enhanced Dosage (Balm): externally, rub 4–5 grams of balm 2–3 times a day for pronounced pain syndrome or joint swelling.

Maximum Dosage (Balm): externally, rub 6 grams of balm 3 times a day for severe forms of myalgia or radiculopathy, under medical supervision.

Preventive Dosage (Balm): externally, 1–2 grams of balm 1 time a day, course of 10 days, 2 times a year, in individuals with chronic overload of muscles and joints.

Pediatric Dosage (Balm): for children over 12 years of age — 1 gram of balm 1 time a day, in the absence of skin damage.

Contraindications (Balm): contraindicated in case of individual intolerance, acute dermatoses, skin damage at the application site; no contraindication data scientifically registered for pregnancy, lactation, and children under 12 years of age.

Side Effects (Balm): in case of overdose may cause skin irritation, redness, itching.

Adjustment for Patient Body Weight: dosage adjustment is not required.

Preparation method (Balm): for 100 grams: 10 grams of dry extract of eurycoma, 50 grams of coconut oil, 20 grams of menthol oil, 20 grams of beeswax. Melt the oils and wax in a water bath at 50 °C, add the extract, mix thoroughly, cool to 30 °C, package in dark glass jars.

Storage Conditions and Shelf Life: store in a tightly closed dark glass container, at a temperature of 8–15 °C, protected from light, shelf life — 12 months; after opening, use within 60 days.

Toxicity and Biosafety of Eurycoma longifolia

The lethal dose (LD₅₀) for powdered root exceeded 6 g/kg upon oral administration to rats, acute toxicity was not detected, mutagenicity was not registered, subchronic 13-week administration (0.6–2 g/kg/day) did not cause significant histopathological changes and did not affect body weight, hematological and biochemical parameters. In mice, the acute LD₅₀ of the alcohol extract is estimated in the range of 1500–2000 mg/kg; for the aqueous extract, LD₅₀ is more than 3000 mg/kg, and at normal doses and chronic use, no changes in liver and kidney function were noted. For standardized extract, the LD₅₀ was ≈6128.71 mg/kg, the therapeutic index ≈213, indicating low toxicity. Some studies highlight that the isolated quassinoid eurycomanone has higher toxicity — its LD₅₀ is ~5.27 g/kg.

Reference: Sholikhah E. N., Wijayanti M. A., Mustofa. In Vivo Antiplasmodial Activity and Acute Toxicity of Standardized Extract of Eurycoma longifolia Jack Root Traditionally Used to Treat Malaria. American Journal of Pharmacology and Toxicology. 2014;9(1):24–28. doi:10.3844/ajptsp.2014.24.28 (https://doi.org/10.3844/ajptsp.2014.24.28)

Pharmacodynamics — Eurycoma longifolia

Eurycoma longifolia contains active biological substances, including quassinoids (e.g., eurycomanone, eurycomolactone), alkaloids and phenolic compounds, which provide a wide range of pharmacodynamic effects through various physiological systems. At the systemic level, extracts and components of the taxon exhibit antioxidant activity, reducing free radical production and decreasing oxidative stress. Anti-inflammatory effects have been noted, associated with inhibition of the NF-κB pathway, which is confirmed by the activity of β-carboline alkaloids and quassinoids against inflammatory mediators PMC+2journals.lww.com+2.

In the endocrine sphere, eurycomanone plays a key role, inhibiting aromatase and phosphodiesterase, thereby stimulating testosterone synthesis through activation of Leydig cells; these effects may be related to the regulation of the hypothalamic-pituitary-gonadal axis and modulation of enzymatic mechanisms of steroidogenesis Википедияmdpi.com. Additionally, anti-estrogenic and proliferation-suppressing effects are possible through modulation of the endocrine system, which in turn supports the balance of sex hormones.

At the cellular level, cytotoxic properties are manifested through induction of apoptosis, increased levels of p53 and Bax, as well as decreased Bcl-2, activating caspases — these mechanisms have antitumor effects journals.lww.com. Antiproliferative activity and induction of programmed cell death have also been confirmed.

n the immune system and at the level of general body defense, antiprotozoal, antimicrobial (bactericidal and protistocidal) activity of root extracts (especially eurycomanone) against a wide range of pathogens is manifested journals.lww.com. Such activity affects immune and tissue responses to infectious agents.

In the nervous system, adaptogenic and anxiolytic effects are noted: extracts help regulate stress hormones and improve mood, which is associated with effects on neurotransmitters and stressogenesis journals.lww.comPMC.

The effect on the skeletal system is expressed through an anti-osteoporotic effect, improvement of bone structural density, stimulation of bone proliferation and reduction of resorption — probably through anabolic hormonal mechanisms and antioxidant protection journals.lww.com.

Thus, the main pharmacodynamic properties of Eurycoma longifolia include antioxidant, anti-inflammatory, endocrine-modulating, antiproliferative, cytotoxic, antimicrobial, adaptogenic and anti-osteoporotic actions. These effects are realized through simultaneous influence on the inflammation system, hormonal balance, immunity, cellular mechanisms and endocrine enzymes journals.lww.com+2lcm.amegroups.org+2.

Pharmacokinetics — Eurycoma longifolia

Pharmacokinetic data for Eurycoma longifolia and its main components are limited, however, it is known that upon oral administration of the quassinoid eurycomanone, absorption is low, with poor bioavailability; presumably the reason is a pronounced "first pass" effect through the liver or poor membrane permeability PubMed. Components are distributed into extravascular fluids, indicating a high volume of distribution Википедия+6PMC+6researchgate.net+6.

The metabolism of these substances has been little studied, but there is no evidence of a significant effect on the activity of CYP450 liver enzymes, indicating a low potential for drug-drug interactions thieme-connect.com. n animal studies, possible enterohepatic recirculation was noted, which may slow elimination and increase duration of action PMCjournals.lww.com.

Excretion occurs through various routes: some of the metabolites are probably excreted in the bile, possibly through the kidneys and gastrointestinal tract, although the exact mechanisms and distribution are not detailed. When administered through mucous membranes (transdermally, rectally, etc.), more local activity with minimal systemic distribution is noted — these data are predominantly theoretical and require confirmation.

Thus, pharmacokinetic features include low oral bioavailability, rapid cellular/tissue uptake, absence of significant enzyme interactions and uncertain elimination, with possible accumulation upon repeated use PubMedthieme-connect.comPMCjournals.lww.com.

Mechanisms of Action and Scientific Rationale — Eurycoma longifolia

Root extracts of Eurycoma longifolia contain numerous biologically active compounds, primarily quassinoids (such as eurycomanone and eurycomanol), as well as β-carboline alkaloids, saponins and phenolic substances. These components realize their effects through complex pharmacological pathways. Eurycomanone in cellular models suppresses the NF-κB signaling pathway by inhibiting IκBα phosphorylation and activation of MAPK, which leads to reduced survival and proliferation of leukemia cells while maintaining low toxicity to healthy lymphocytes Википедия+15ResearchGate+15PMC+15. Methanolic root extract also exhibits a potent anti-inflammatory effect, suppressing NF-κB activity in studied models PMC.

At the level of cellular targets, these compounds act on endothelial cells, macrophages, and other components of the immune system, reducing the production of pro-inflammatory cytokines and reactive oxygen species. Additional antioxidant effects are provided by the interaction of phenolic compounds with oxidants, reducing oxidative stress at the systemic level PMCphcogj.com.

In the endocrine system, Eurycoma longifolia affects enzyme systems such as aromatase and phosphodiesterase, helping to enhance steroid biosynthesis of testosterone. This is realized through modulation of steroidogenic enzyme levels and hormonal balance Википедия. Such effects pertain to the hypothalamic-pituitary-gonadal axis, contributing to the regulation of reproductive hormone production.

Thus, Eurycoma longifolia exerts anti-inflammatory, antioxidant, cytotoxic (selective), modulating-endocrine and immunomodulatory effects through specific molecular targets — NF-κB, MAPK, aromatase, phosphodiesterase, immune system cells pubs.acs.org+13ResearchGate+13onlinelibrary.wiley.com+13.

Synergy — Eurycoma longifolia

To date, there are very few scientific publications directly confirming the pharmacological synergy of Eurycoma longifolia with other plants or compounds. There are no reliable data from in vitro, in vivo or clinical studies indicating additive or potentiating effects in combination with other pharmacological agents. Thus, any mention of synergy without a reliable reference is considered non-hypothetical and unconfirmed.

Geography of Use and Traditional Medicine — Eurycoma longifolia

Eurycoma longifolia, known in Southeast Asia under the names "tongkat ali" (Malaysia), "pasak bumi" (Indonesia), "kasip fatima" (in some Malay sources — as a synonym for other plants, but with overlapping contexts of use), is traditionally used in the folk medical practices of Malaysia, Indonesia, Thailand, Vietnam, Cambodia, Laos and the Philippines. The main range of wild populations covers the tropical forests of the Malay Peninsula, Kalimantan, Sumatra and Borneo, which determined its ethnobotanical role as a plant symbolizing vitality. In traditional Malay and Indonesian medicine, plant roots are used to prepare decoctions and aqueous infusions used as drinks, as well as in baths and wraps. In Thai tradition, the plant is known as "พลึง" and is used mainly in the form of macerates and infusions in combination with other medicinal herbs.

Historical references to Eurycoma longifolia are found in written sources of the early 19th century in Malay herbalists and ethnographic descriptions, where the plant is characterized as a "remedy for strengthening spirit and body." Archaeoethnobotanical data on earlier use are absent, but oral traditions indicate centuries-old tradition of use among the indigenous peoples of Kalimantan and Sumatra. In the cultural practices of some peoples of Borneo, plant roots were used in ritual decoctions during initiations and fertility festivals. In rare cases, the plant is mentioned as an element of male amulets and a symbol of protection.

In a non-medical context, Eurycoma longifolia was sometimes used as a powder or pieces of root stored in dwellings as a talisman, and in some villages — in smoke rituals for cleansing premises.