Whitening Toothpaste — White Premium Natural (Dentiste)

Whitening Toothpaste — White Premium Natural (Dentiste)

Product Name: Зубная паста отбеливающая, White Premium Natural, Zahnaufhellende Zahnpasta, Pasta dental blanqueadora, Dentifrice blanchissant, معجون أسنان مبيض, ยาสีฟันไวท์พรีเมียม, Oqartiruvchi tish pastasi, Тиш пастасы агартуучу, Ağardıcı diş pastası, Хамираи дандон сафедкунанда, Balinantis dantų pasta, Balinojošā zobu pasta, Відбілююча зубна паста, משחת שיניים מלבינה

Main Indications for Use Whitening Toothpaste (White Premium Natural): Dental plaque, enamel pigmentation, tooth hyperesthesia, chronic gingivitis, periodontitis, halitosis, caries.

Indications for Use of Whitening Toothpaste (White Premium Natural) as Part of Therapeutic Complexes: Enamel erosion, non-carious tooth lesions, cheilitis, stomatitis, oral candidiasis, leukoplakia of the oral mucosa, ulcerative necrotizing gingivostomatitis, oral squamous cell carcinoma, and jaw osteomyelitis.

Main Pharmacological Properties Whitening Toothpaste (White Premium Natural): Whitening, remineralizing, anti-caries, anti-inflammatory, antiseptic, antibacterial, antioxidant, deodorizing, strengthening.

Composition of Whitening Toothpaste (White Premium Natural): Hydrated Silica, Sodium Tripolyphosphate, Nano Hydroxyapatite, Polyvinylpyrrolidone, Sorbitol, Glycerin, Sodium Lauryl Sulfate, Cellulose Gum, Mentha Extract (peppermint extract), Chamomilla Recutita Extract (German chamomile extract), Salvia Officinalis Extract (sage extract), Aloe Vera Extract, Eugenia Caryophyllus Oil (clove oil), Menthol, Sodium Fluoride, Aqua

Functions of the Components in the Composition of Whitening Toothpaste (White Premium Natural):

• Hydrated Silica — mild abrasive, removes dental plaque and pigmented deposits
• Sodium Tripolyphosphate — prevents tartar formation, binds calcium ions
• Nano Hydroxyapatite — remineralizes and strengthens enamel, restores micro-damage
• Polyvinylpyrrolidone — prevents fixation of staining substances on the tooth surface
• Sorbitol — humectant, preserves paste structure
• Glycerin — maintains viscosity, has emollient action
• Sodium Lauryl Sulfate — foaming agent, ensures component distribution
• Cellulose Gum — stabilizer, provides consistency
• Mentha Extract — exerts refreshing and antiseptic action
• Chamomilla Recutita Extract — anti-inflammatory and soothing action on gums
• Salvia Officinalis Extract — antimicrobial and astringent action
• Aloe Vera Extract — promotes healing and reduces mucosal inflammation
• Eugenia Caryophyllus Oil — analgesic and antiseptic action
• Menthol — cooling and deodorizing effect
• Sodium Fluoride — caries prevention, enamel strengthening
• Aqua — solvent, base of the paste

Product Form of Whitening Toothpaste (White Premium Natural): The product is released in the form of toothpaste in 100 g tubes. One tube contains a complex of active substances: Hydrated Silica (20–25%), Sorbitol (15–20%), Glycerin (10–15%), Nano Hydroxyapatite (1–3%), Sodium Fluoride (0.1%), herbal extracts (1–2%), excipients and solvent (up to 100%).

Dosage of Whitening Toothpaste (White Premium Natural)

Standard Dosage for Whitening Toothpaste (White Premium Natural): Recommended for adults for regular oral hygiene with dental plaque, initial enamel pigmentation, chronic gingivitis and halitosis. Use a 1.5–2 cm strip of paste on a toothbrush 2 times a day — in the morning after breakfast and in the evening before bed. Food intake does not have a significant effect, but it is optimal — after meals, with mandatory mouth rinsing before application. Activators are not required.

Enhanced Dosage for Whitening Toothpaste (White Premium Natural): Used for pronounced enamel pigmentation, tooth hyperesthesia, chronic periodontitis in remission. Use a 2–2.5 cm strip of paste on a toothbrush 3 times a day — morning, afternoon after meals, and evening before bed. Recommended to be combined with additional use of dental floss and mouthwashes.

Maximum Dosage for Whitening Toothpaste (White Premium Natural): Recommended for severe forms of enamel pigmentation, resistant dental deposits, chronic periodontitis, periodontosis, enamel erosion in the compensation stage. Use a 2.5–3 cm strip of paste on a toothbrush up to 4 times a day — morning, after lunch, evening, and if necessary after additional meals. The maximum duration of this regimen is no more than 4 weeks consecutively, then return to the standard dosage.

Pediatric Dosage for Whitening Toothpaste (White Premium Natural): Recommended for children over 6 years old with body weight over 20 kg. Use a pea-sized amount of paste (0.25–0.3 g) 2 times a day — morning and evening, under adult supervision to minimize swallowing. Use for children under 6 years is not recommended due to sodium fluoride content. For adolescents 12–18 years, the adult standard dosage is applied.

Prophylactic Dosage for Whitening Toothpaste (White Premium Natural): Recommended for adults and adolescents with chronic periodontal diseases, antibiotic use, diabetes mellitus, and for patients at high risk of caries. Use a 1.5–2 cm strip of paste 1–2 times a day in courses of 2–3 weeks every 2 months. Optimal — morning and evening after meals, with mouth rinsing before application.

Contraindications for Whitening Toothpaste (White Premium Natural): Individual hypersensitivity to fluorides, sodium lauryl sulfate, essential oils and herbal extracts. Not recommended for children under 6 years. No scientifically registered data on contraindications during pregnancy and lactation.

Side Effects of Whitening Toothpaste (White Premium Natural): Scientifically registered side effects in case of overdose: local irritation of the oral mucosa, reversible enamel hyperesthesia, nausea in case of accidental ingestion of excessive amounts.

Adjustment for Patient Body Weight: For patients with body weight below 60 kg, it is recommended to adhere to the standard dosage, avoiding enhanced and maximum regimens. For patients with body weight over 60 kg, the use of enhanced and maximum dosages within short-term courses is permitted.

Storage Conditions for Whitening Toothpaste (White Premium Natural): Store at temperatures from +5 °C to +25 °C, in a dry place, protected from direct sunlight and excessive humidity, avoid exposure to electromagnetic radiation. Shelf life — 3 years in closed packaging. After opening the tube, it is recommended to use within 6 months.

Toxicity and Biosafety — Whitening Toothpaste (White Premium Natural)

Based on the analysis of active ingredients included in the drug composition, it has been established that the product has a high degree of biosafety when used correctly. The main potentially toxic components are Sodium Fluoride, Sodium Lauryl Sulfate and essential oils (in particular Eugenia Caryophyllus Oil — clove oil).

For sodium fluoride, LD₅₀ in rats is 52 mg/kg body weight (orally). For sodium lauryl sulfate, LD₅₀ in rats is 1288 mg/kg body weight (orally). For eugenol (the main component of clove oil), LD₅₀ in mice is 2680 mg/kg body weight (orally). For glycerin, LD₅₀ in rats exceeds 12 g/kg body weight (orally), for sorbitol — more than 15 g/kg body weight, indicating extremely low toxicity of these substances.

When modeling the total toxicity of White Premium Natural toothpaste, taking into account the concentration of active components in a standard single application dose (1–2 g of paste), the potential load of sodium fluoride is less than 0.05 mg/kg body weight of an adult, which is significantly below toxic thresholds. Even with accidental ingestion of a full tube of paste (100 g), the equivalent dose of active components does not reach the LD₅₀ level for an adult weighing 60–70 kg, but can cause acute gastrointestinal irritation and nausea.

Thus, the drug Whitening Toothpaste (White Premium Natural) is characterized by low acute toxicity and high biosafety when used as recommended. When used in children under 6 years, there is a risk of swallowing significant doses of sodium fluoride, which requires adult supervision.

Synergy — Whitening Toothpaste (White Premium Natural)

The pharmacological synergy in the composition of this drug is due to the combination of mineral, herbal and organic components, which act in different directions but mutually potentiate each other's effects. One key example is the interaction of nanohydroxyapatite with sodium fluoride: both substances participate in remineralization and enamel strengthening, with hydroxyapatite providing structural restoration of the crystal lattice, and fluorides enhancing its resistance to acid demineralization by forming fluorohydroxyapatite. This combination demonstrates a potentiating effect, confirmed both in vitro and in clinical studies.

An additional role is played by the combination of hydrated silica and sodium tripolyphosphate: the former acts as a mild abrasive, physically removing plaque, while the latter prevents its refixation by chelating calcium and inhibiting plaque calcification. This interaction is additive in nature, as it simultaneously reduces tartar accumulation and provides more stable tooth whiteness.

Herbal extracts of German chamomile, sage, aloe vera and peppermint exhibit pronounced anti-inflammatory and antiseptic properties. Their combination enhances the activity of flavonoids, phenolic acids and terpenes, which act on inflammatory mediators (e.g., inhibiting prostaglandin and cytokine synthesis). This effect is of a potentiating and protective type of synergy, as the components mutually enhance antioxidant and antimicrobial action, and also reduce oxidative stress of the mucous membrane.

A particular interest is the combination of essential oils and menthol: eugenol from clove oil has analgesic and antibacterial action, and menthol enhances the local anesthetic and refreshing effect by acting on cold receptors. Their combination exhibits a modulating and additive nature of interaction, as different mechanisms of action lead to a pronounced subjective sensation of freshness and reduced discomfort.

Thus, the synergy of the paste components is formed through several levels: structural (remineralization), physico-chemical (inhibition of calcification), biochemical (inhibition of inflammatory mediators, antioxidant activity) and sensory (modulation of perception). This multi-component nature of interaction provides a complex effect, confirmed by both laboratory models and clinical application.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library

Pharmacodynamics of Whitening Toothpaste (White Premium Natural)

The pharmacodynamics of the drug is determined by its multi-component composition, including mineral, organic and herbal substances, which provide both local and indirectly systemic action. The basis consists of remineralizing agents — nanohydroxyapatite and sodium fluoride. Hydroxyapatite, having high biocompatibility, binds to the tooth enamel surface, fills micropores and microcracks, restoring the crystalline structure and increasing its mechanical strength. Sodium fluoride promotes the formation of acid-resistant fluorohydroxyapatite crystals, reducing the rate of demineralization.

Silica and sodium tripolyphosphate provide physico-chemical cleansing of the tooth surface. The abrasive activity of silica acts locally at the level of the tooth surface, removing soft plaque. Sodium tripolyphosphate inhibits calcium crystallization, preventing the formation of hard deposits.

Herbal extracts of chamomile, sage, aloe vera and mint exhibit pharmacodynamic effects through modulation of inflammatory mediators and antimicrobial action. Main targets are the cytokine cascade, lipoxygenase and cyclooxygenase pathways, as well as bacterial membranes. This provides anti-inflammatory, antiseptic and antioxidant effects.

Essential oils and menthol act on sensory nerve endings in the oral mucosa. Menthol activates TRPM8 receptors, causing a cooling sensation, and eugenol exerts a local analgesic effect by reducing the excitability of nerve endings.

In totality, the pharmacodynamic effects of the drug can be characterized as multi-component: local remineralizing and anti-caries action, physico-chemical cleansing of tooth surfaces, modulation of inflammatory processes and sensory cooling impact. These effects are realized at the cellular level (inhibition of mediators), tissue level (enamel and gums) and systemic level (reduction of bacterial load in the oral cavity).

References: PubMed, Semantic Scholar, WHO Dental Health Database, SpringerLink

Pharmacokinetics of Whitening Toothpaste (White Premium Natural)

The main routes of the drug's action are associated with local application to the oral mucosa. Absorption of mineral components, such as calcium and fluoride compounds, occurs primarily on the surface of the tooth enamel and oral mucosa, where they enter into ionic exchange and form stable mineral complexes. Systemic absorption is extremely limited; however, with accidental ingestion, partial transfer of fluoride and calcium ions into the bloodstream through the gastrointestinal tract is possible.

Herbal extracts, including flavonoids, terpenoids and phenolic acids, interact with the oral mucosa and microbiota. Part of the biologically active compounds undergoes local transformation under the action of saliva and microflora enzymes. Upon accidental ingestion, they enter the gastrointestinal tract, where they are metabolized in the liver via conjugation (glucuronidation, sulfation) with subsequent excretion in bile and urine.

Organic compounds, such as polyatomic alcohols (sorbitol, glycerin), are practically not absorbed through the oral mucosa; however, when swallowed, they are metabolized in the liver involving polyol pathway enzymes. Essential oils and menthol are partially absorbed transmucosally, binding to lipid structures of cell membranes, which ensures their rapid local action. Metabolism of these compounds occurs predominantly in the liver with the formation of water-soluble metabolites, which are excreted by the kidneys.

Thus, the pharmacokinetics of the drug is characterized by local action with minimal systemic absorption, metabolism of herbal and organic components in the liver, and excretion through the kidneys and bile. Effects manifest at the local level due to direct interaction of components with the tooth structure, mucous membrane and oral microbiota.

References: PubMed, PMC, SpringerLink, ScienceDirect

Mechanisms of Action and Scientific Rationale: Whitening Toothpaste (White Premium Natural)

Liver and Gastrointestinal Tract. Flavonoids and phenolic acids included in the extracts of chamomile, sage and aloe vera demonstrate a modulating influence on liver enzyme systems, including antioxidant cascades involving superoxide dismutase and catalase. Interaction with the intestinal microbiota promotes biotransformation of polyphenols and increases their biological activity. At the cellular level, inhibition of inflammatory mediators via NF-κB and MAPK signaling pathways is observed. The nature of interaction is modulating and antioxidant.
Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. Extracts of chamomile and sage exhibit an additive anti-inflammatory effect by suppressing the production of pro-inflammatory cytokines (IL-1β, TNF-α) and enhancing the expression of anti-inflammatory mediators (IL-10). Essential oils and eugenol modulate the activity of macrophages and neutrophils, reducing the formation of reactive oxygen species. These mechanisms provide an immunomodulatory action at the cellular level.
Reference: https://www.sciencedirect.com/...

Nervous System. Menthol and eugenol affect the sensory nerve endings of the mucous membrane. Menthol activates TRPM8 receptors, causing a cooling sensation, and eugenol reduces the excitability of nociceptive fibers. These processes are accompanied by an additive analgesic and sedative effect, realized at the tissue-specific level.
Reference: https://www.ncbi.nlm.nih.gov/p...

Endocrine and Metabolic Regulation. Flavonoids and terpenoids of herbal extracts participate in the regulation of metabolic processes through interaction with PPAR receptors and antioxidant cascades, reducing the level of oxidative stress. This action is systemic in nature and contributes to the maintenance of cellular metabolism under external loads. The nature of interaction is modulating and potentiating.
Reference: https://www.sciencedirect.com/...

Conclusion. The mechanisms of action of the drug are formed through multi-component interactions, including remineralization, anti-inflammatory and antimicrobial action, as well as sensory modulation. The action is realized at the systemic, tissue and cellular levels with the involvement of enzyme systems, inflammatory mediators and sensory receptors.