Burn Regeneration Gel — Burrny Gel (BOAM)

Burn Regeneration Gel — Burrny Gel (BOAM)

Product Name: Регенерация ожогов гель, Burrny Gel, Regenerationsgel für Verbrennungen, Gel regenerador para quemaduras, Gel de régénération pour brûlures, جل تجديد الحروق, เจลฟื้นฟูบาดแผลไฟไหม้, Yonish jarohlarini qayta tiklash jeli, Күйүктөрдү регенерациялоочу гель, Yanıqlar üçün regenerasiyaedici gel, Гели барқароркунандаи сӯхтагӣ, Nudegimų regeneracinis gelis, Apdegumu reģenerācijas gels, Гель для регенерації опіків, ג'ל רגנרציה לכוויות

Main Indications for Use of Burn Regeneration Gel (Burrny Gel): First and second-degree skin burns, sunburns, steam burns, scalds, superficial thermal skin injuries, post-traumatic inflammatory skin lesions, skin irritation after thermal exposure.

Indications for Burn Regeneration Gel (Burrny Gel) as Part of Therapeutic Complexes: Chronic trophic skin ulcers of various etiologies, diabetic angiopathy with skin lesions, radiation dermatitis, malignant skin neoplasms (melanoma, basal cell carcinoma, squamous cell skin carcinoma) as part of symptomatic therapy, combined treatment of cancer patients for the prevention of skin complications, complicated purulent wounds, dermatitis of allergic origin, systemic connective tissue diseases with skin syndrome.

Main Pharmacological Properties of Burn Regeneration Gel (Burrny Gel): Anti-inflammatory, analgesic, wound-healing, antioxidant, moisturizing, anti-edematous, regenerative, antibacterial, antiseptic, immunomodulatory, cytoprotective.

Composition of Burn Regeneration Gel (Burrny Gel): Aloe barbadensis extract (Aloe Vera extract), Gel base.

Functions of the Components in Burn Regeneration Gel (Burrny Gel):

• Aloe barbadensis extract (Aloe Vera extract): Provides anti-inflammatory, wound-healing, and regenerative action, accelerates skin epithelialization, reduces pain and inflammation, has an antimicrobial effect.
• Gel base: Creates an optimal consistency for application, forms a protective film on the skin surface, maintains hydration, and promotes prolonged action of the active component.

Product Form of Burn Regeneration Gel (Burrny Gel): Gel for topical use, available in 30 g aluminum tubes. Every 100 g of the preparation contains Aloe barbadensis (Aloe Vera) — 70 g, the remaining components — gel base. Total weight of one tube — 30 g.

Dosage of Burn Regeneration Gel (Burrny Gel)

Standard Dosage for Burn Regeneration Gel (Burrny Gel): Topically, for adults — apply a thin layer to the affected skin area 3–4 times a day. Used for first-degree burns, sunburns, superficial thermal skin injuries without significant blistering. Use after washing the affected area with cool water. Application specifics: apply during the day and evening, without additional activators, can be combined with light dressings.

Enhanced Dosage for Burn Regeneration Gel (Burrny Gel): Topically, for adults — apply a thin layer 4–6 times a day. Used for second-degree burns with blisters, inflammatory skin lesions with pronounced pain syndrome, as part of complex therapy for post-traumatic skin injuries. Application specifics: for the first 2–3 days, more frequent application every 4–6 hours is recommended, then switching to the standard dosage. Use under a sterile wet dressing is allowed.

Maximum Dosage for Burn Regeneration Gel (Burrny Gel): Topically, for adults — up to 8 times a day with an interval of at least 2 hours. Used for severe second-degree burns on limited skin areas, for complicated inflammatory processes, and as part of inpatient treatment. Application specifics: only as prescribed by a doctor, combination with systemic analgesics or antibiotics is allowed. Use under control of tissue damage and healing dynamics.

Pediatric Dosage for Burn Regeneration Gel (Burrny Gel): For children over 3 years of age and weighing from 15 kg — apply a thin layer to the affected skin area 2–3 times a day. Used for sunburns and superficial thermal skin injuries. For children under 3 years of age and weighing less than 15 kg, insufficient safety data is available. Application specifics: only under adult supervision, avoid contact with mouth, eyes, and mucous membranes.

Prophylactic Dosage for Burn Regeneration Gel (Burrny Gel): For adults and adolescents with chronic dermatoses, increased skin photosensitivity, frequent sun exposure — apply a thin layer 1–2 times a day to exposed skin areas to reduce the risk of inflammatory reactions and burns. Use primarily in the morning and during the day.

Contraindications for Burn Regeneration Gel (Burrny Gel): Individual hypersensitivity to the components of the preparation, allergic reactions to Aloe barbadensis. Data on contraindications during pregnancy, lactation, and in children under 3 years of age are not scientifically registered.

Side Effects of Burn Regeneration Gel (Burrny Gel): In rare cases, with overdose or excessively frequent application, local skin irritation, hyperemia, itching, contact dermatitis are possible.

Adjustment Based on Patient Body Weight: For patients weighing less than 60 kg, no adjustment is required, as the preparation is applied topically and systemic action is minimal. For patients weighing more than 60 kg, dosage adjustment is also not required; the application regimen remains standard.

Storage Conditions for Burn Regeneration Gel (Burrny Gel): Store in a dry, cool place at a temperature not exceeding 25 °C, away from direct sunlight and heat sources. Avoid exposure to electromagnetic radiation and storage near heating appliances. Shelf life — 3 years from the date of manufacture. After opening the tube, use within 6 months, provided tightness and sanitary rules are observed.

Toxicity and Biosafety — Burn Regeneration Gel (Burrny Gel)

Toxicity data for the preparation are based on the study of the main active component — Aloe barbadensis (Aloe Vera). Experimental studies on animals have shown that aqueous and alcoholic extracts of aloe have extremely low acute toxicity. For dry Aloe Vera extract, the LD₅₀ upon oral administration to rats is over 15 g/kg body weight, indicating a practically non-toxic profile of the substance.

Considering the content of Aloe barbadensis in the preparation (70 g per 100 g of gel) and the topical route of administration, the cumulative toxicity of Burrny Gel is estimated as extremely low; the risk of systemic intoxication with proper use is absent.

Cellular studies confirm that at concentrations up to 5000 µg/ml, Aloe barbadensis extract does not cause cytotoxicity for epithelial cell cultures.

Thus, Burrny Gel is classified as a biologically safe preparation for topical use. If large quantities are accidentally ingested, mild gastrointestinal irritation is possible, but there is no threat of systemic toxic damage.

Synergy — Burn Regeneration Gel (Burrny Gel)

The main active component of the gel is Aloe barbadensis (Aloe Vera), rich in biologically active substances, including polysaccharides (acemannan), anthraquinones (aloin, emodin), flavonoids, vitamins (ascorbic acid, tocopherol), minerals, and amino acids. The pharmacological synergy when using preparations based on Aloe Vera is determined by several levels of interaction. At the cellular level, an additive and potentiating effect of polysaccharides and antioxidants is observed, leading to reduced oxidative stress, protection of cell membranes, and acceleration of reparative processes. At the tissue level, a modulatory effect on inflammatory mediators has been proven, including inhibition of cyclooxygenase-2 and suppression of pro-inflammatory cytokine synthesis, which is enhanced when aloe is combined with flavonoids from other plants, for example Camellia sinensis or Curcuma longa. In clinical practice, synergy of Aloe Vera with honey has been noted, manifesting as potentiation of the antimicrobial effect and acceleration of epithelialization of damaged tissues, as well as with tea tree oil (Melaleuca alternifolia), where the synergy is protective and modulatory in nature. In vitro experiments have shown that the combination of Aloe Vera with vitamin C enhances antioxidant activity and stabilizes the collagen matrix, while the combination with zinc provides an additional immunomodulatory effect. The interaction of aloe components with other taxa can be classified as predominantly potentiating and additive, with a pronounced tissue-specific direction of action. The totality of data indicates that Aloe barbadensis demonstrates a wide range of synergies with other natural compounds, providing a comprehensive enhancement of antioxidant, anti-inflammatory, antimicrobial, and regenerative action, which is important for biomedical and pharmacological applications.

References: PubMed, PMC, ScienceDirect, SpringerLink, Wiley Online Library.

Pharmacodynamics of Burn Regeneration Gel (Burrny Gel)

The pharmacodynamic properties of Aloe barbadensis are determined by the combination of polysaccharides, anthraquinones, amino acids, vitamins, and trace elements included in the extract. At the local level, the preparation exerts an anti-inflammatory effect by inhibiting the activity of pro-inflammatory mediators and enzymes, including prostaglandins and leukotrienes. Antioxidant components, such as ascorbic acid, tocopherol, and polyphenols, reduce the level of free radicals, stabilize cell membranes, and reduce the severity of oxidative stress. Polysaccharides, mainly acemannan, exhibit a modulatory influence on the immune system, stimulating macrophage activity and phagocytosis, and inducing the synthesis of interleukins and growth factors. At the skin level, stimulation of fibroblasts and increased collagen synthesis are observed, contributing to accelerated tissue regeneration. Anthraquinone compounds, in particular aloin and emodin, have a mild antimicrobial effect and contribute to the suppression of pathogenic microflora growth. The combined action of the components provides a multicomponent pharmacological profile: anti-inflammatory, antioxidant, antimicrobial, moisturizing, and regenerative. The preparation acts primarily at the local level; however, due to the systemic modulatory effect of polysaccharides and antioxidants, it can have an indirect effect on the immune system and cellular defense processes. Thus, the pharmacodynamics of Aloe barbadensis is characterized by tissue-specific and cell-mediated action, based on the regulation of inflammatory cascades, protection against oxidative damage, and stimulation of repair processes.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, WHO.

Pharmacokinetics of Burn Regeneration Gel (Burrny Gel)

With transdermal administration, the active substances of Aloe barbadensis penetrate the epidermal and dermal layers of the skin depending on their lipophilicity and molecular weight. Polysaccharides, such as acemannan, have high hydrophilicity, which limits their penetration into the deep layers of the skin; they act primarily at the level of the stratum corneum and epidermis, creating a moisturizing and protective barrier. Flavonoids and anthraquinone compounds, having greater lipophilicity, are able to penetrate the dermal layer and interact with cell membranes and protein structures.

The distribution of active substances is limited to the site of application; systemic absorption is minimal. However, with damaged skin, some components may penetrate into the microcirculatory bed. Polysaccharides entering the bloodstream are distributed primarily in the plasma and tissues with high macrophage content. Anthraquinones bind to plasma proteins, primarily albumin, which determines their temporary deposition.

The metabolism of active Aloe Vera components occurs primarily in the liver with the participation of conjugation enzymes (glucuronidation, sulfation), as well as in the intestinal microflora upon accidental oral intake. Polysaccharide metabolites undergo enzymatic breakdown to oligosaccharides and monosaccharides. Anthraquinone derivatives can undergo oxidation and reduction, forming less active metabolites.

Excretion occurs primarily by the kidneys in the form of polar metabolites, and also partially with bile and sweat. With topical application, systemic accumulation is extremely unlikely, since most components realize their action locally and do not reach high concentrations in the systemic circulation.

References: PubMed, PMC, ScienceDirect, SpringerLink.

Mechanisms of Action and Scientific Rationale: Burn Regeneration Gel (Burrny Gel)

Liver and Gastrointestinal Tract. Aloe Vera polysaccharides exhibit a modulating effect on liver enzyme systems, including phase II biotransformation (glucuronyltransferases, sulfotransferases), which contributes to the accelerated detoxification of reactive metabolites. Anthraquinones and flavonoids demonstrate lipotropic and antioxidant action, reducing lipid peroxidation in hepatocyte membranes. The nature of the interaction is additive and membrane-stabilizing, the level of action is tissue-specific.

Reference: https://pubmed.ncbi.nlm.nih.go...

Immune System. Acemannan stimulates the activity of macrophages and neutrophils, increases the secretion of interleukins and growth factors, which exerts a modulating and potentiating effect on innate immune mechanisms. Flavonoids and antioxidants additionally regulate NF-κB and MAPK signaling pathways, suppressing the synthesis of pro-inflammatory cytokines. The nature of the interaction is potentiating and modulating, the level of action is cellular.

Reference: https://pubmed.ncbi.nlm.nih.go...

Nervous System. Anthraquinone compounds of aloe can indirectly modulate the activity of pain and inflammation mediators by suppressing cyclooxygenase-2 (COX-2) and lipoxygenase (LOX). Influence on sensory nerve endings leads to reduced pain sensitivity and burning. The action is characterized as additive and tissue-specific, aimed at local nerve endings in the skin.

Reference: https://www.sciencedirect.com/...

Endocrine and Metabolic Regulation. Biologically active polysaccharides and phytosterols of aloe modulate lipid and carbohydrate metabolism, exerting an indirect influence on the endocrine system. Regulation of JAK/STAT and AMPK signaling cascades contributes to improved cellular energy metabolism and increased tissue resistance to oxidative stress. The nature of the interaction is modulating and systemic, pharmacological targets are energy metabolism enzymes, cell surface receptors.

Reference: https://pubmed.ncbi.nlm.nih.gov/28689409/