Advanced Repair Night Cream (ABHAI)

Advanced Repair Night Cream (ABHAI)

Product Name: Регенерация ночной крем, Advanced Repair Night Cream, Regenerierende Nachtcreme, Crema nocturna de regeneración, Crème de nuit régénérante, كريم ليلي للتجديد, ครีมกลางคืนฟื้นฟูผิว, Tungi tiklanish uchun tungi krem, Түнкү регенерациялоочу крем, Gecə regenerasiyaedici krem, Креми шабонаи барқароркунанда, Atkuriamasis naktinis kremas, Atjaunojošs nakts krēms, Відновлювальний нічний крем, קרם לילה להתחדשות

Main Indications for Advanced Repair Night Cream: Senile wrinkles, expression lines, facial skin atrophy, facial dry seborrhea, facial skin xerosis, photoaging of the skin, premature skin aging, facial skin hyperkeratosis, dermatoelastosis, impaired skin barrier function, post-inflammatory hyperpigmentation.

Indications for Advanced Repair Night Cream as Part of Therapeutic Complexes: Atopic dermatitis, rosacea, facial seborrheic dermatitis, acne vulgaris, actinic keratosis, basal cell carcinoma of the skin, squamous cell carcinoma of the skin, melanoma of the skin, psoriasis vulgaris, chronic radiation dermatitis, facial skin scar changes, chronic eczema.

Main Pharmacological Properties of Advanced Repair Night Cream: Antioxidant, anti-inflammatory, regenerative, antimicrobial, moisturizing, nourishing, reparative, keratoprotective, photoprotective.

Ingredients: Deionized Water, Dimethicone, Caprylic/Capric Triglyceride, Isopropyl Palmitate, Methylpropanediol, Cetyl Alcohol, PEG-40 Hydrogenated Castor Oil, Polysorbate 60, Glyceryl Stearate SE, Hydrogenated Polydecene, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phenoxyethanol, Glycerin, Sorbitan Stearate, Propylene Glycol, Centella Asiatica Extract, Neopentyl Glycol Dicaprate, Butylene Glycol, Hyaluronic Acid, Chlorphenesin, Fragrance, Sodium Hyaluronate, Tocopheryl Acetate, Cannabis spp. Extract (Cannabidiol-Isolated Powder), Bio-saccharide Gum-1, Disodium EDTA, Butyrospermum Parkii Butter, Centotheca Lappacea Extract, Morus Alba Leaf Extract, Carbomer, Garcinia Mangostana Peel Extract, Polysorbate 20, Polysorbate 80, Sodium Benzoate, Palmitoyl Pentapeptide-4.

Functions of Components in Advanced Repair Night Cream:

• Deionized Water — solvent, moisturizing base.
• Dimethicone — softening agent, forms a protective film.
• Caprylic/Capric Triglyceride — source of fatty acids, nourishes the skin.
• Isopropyl Palmitate — emollient, improves skin texture.
• Methylpropanediol — solvent, enhances penetration of active substances.
• Cetyl Alcohol — emulsion stabilizer, softening agent.
• PEG-40 Hydrogenated Castor Oil — emulsifier, stabilizer.
• Polysorbate 60/20/80 — emulsifiers, provide consistency.
• Glyceryl Stearate SE — emulsifier, nourishing component.
• Hydrogenated Polydecene — humectant, softening agent.
• Phenoxyethanol, Chlorphenesin, Sodium Benzoate — preservatives.
• Glycerin, Propylene Glycol, Butylene Glycol — humectants, increase skin elasticity.
• Centella Asiatica Extract — regenerative, anti-inflammatory action.
• Neopentyl Glycol Dicaprate — softening agent, improves sensory properties.
• Hyaluronic Acid, Sodium Hyaluronate — deep moisturization, moisture retention.
• Tocopheryl Acetate (Vitamin E) — antioxidant, protection against aging.
• Cannabis spp. Extract (CBD) — anti-inflammatory, antioxidant action.
• Bio-saccharide Gum-1 — moisturizing and soothing agent.
• Disodium EDTA — formula stabilizer.
• Butyrospermum Parkii Butter (Shea butter) — nourishment, softening.
• Centotheca Lappacea Extract — antioxidant action.
• Morus Alba Leaf Extract — brightening, antioxidant effect.
• Carbomer — viscosity stabilizer.
• Garcinia Mangostana Peel Extract — antimicrobial, antioxidant action.
• Palmitoyl Pentapeptide-4 — anti-wrinkle peptide, stimulates collagen synthesis.

Product Form of Advanced Repair Night Cream: The product is released in the form of a cosmetic cream for external use, packaged in 50 ml glass jars. One dose of cream (≈1 ml) contains a complex of active components: plant extracts (Centella asiatica, Cannabis spp. — 0.1% Cannabidiol, Garcinia mangostana, Morus alba, Centotheca lappacea), hyaluronic acid, vitamin E, shea butter, peptide Palmitoyl Pentapeptide-4, as well as auxiliary substances (emollients, emulsifiers, humectants, preservatives).

Dosage of Advanced Repair Night Cream

Standard Dosage for Advanced Repair Night Cream: Apply 1–1.5 ml of cream (a strip 2–2.5 cm long) once a day in the evening to cleansed skin of the face and neck. Recommended for facial skin dryness, photoaging of the skin, the appearance of first expression lines, post-inflammatory hyperpigmentation. Apply after cleansing and toning the skin, 30–40 minutes before sleep, without additional activators.

Intensive Dosage for Advanced Repair Night Cream: Apply 2 ml of cream (a strip 3 cm long) once a day in the evening to the skin of the face, neck, and décolleté. Recommended for pronounced wrinkles, age-related skin atrophy, dermatoelastosis, facial skin hyperkeratosis. In the intensive regimen, use over a serum with hyaluronic acid or vitamin C is permitted, with the cream being applied as the final layer.

Maximum Dosage for Advanced Repair Night Cream: Apply up to 2.5–3 ml of cream (a strip 3.5–4 cm long) in the evening, evenly distributing over the face, neck, and upper chest. Can be used daily in courses of up to 3 months for pronounced skin photoaging, deep wrinkles, post-inflammatory skin changes after acne or radiation therapy. Do not apply more than once a day.

Pediatric Dosage for Advanced Repair Night Cream: The product is not intended for use in children under 12 years old. There is no clinical study data on safety in children and adolescents under 18 years old. For adolescents over 12 years old with pronounced skin xerosis or dermatoelastosis, application of a minimal dose of 0.5–1 ml once a day in the evening is possible, without combination with aggressive active agents.

Preventive Dosage for Advanced Repair Night Cream: Apply 0.5–1 ml of cream once a day in the evening in courses of 2–3 months, 2–3 times a year. Recommended for chronic conditions: atopic dermatitis in remission, chronic dry skin, tendency to photoaging, early age-related changes in patients over 30 years old.

Contraindications for Advanced Repair Night Cream: Individual hypersensitivity to the components of the product (including phenoxyethanol, chlorphenesin, fragrances). Acute phase of inflammatory dermatoses. Scientifically registered data on contraindications during pregnancy, lactation, and in childhood under 12 years old is not available.

Side Effects of Advanced Repair Night Cream: Overdose or excessive application may cause contact dermatitis, local skin irritation, erythema, burning, or itching. In rare cases — the appearance of closed comedones due to film-forming components (dimethicone, isopropyl palmitate).

Adjustment Based on Patient Body Weight: For patients with body weight below 60 kg, the dosage remains standard (1–1.5 ml), as the product is applied externally and acts locally. Dose adjustment depending on body weight is not required.

Storage Conditions for Advanced Repair Night Cream: Store in a dry place, protected from direct sunlight, at a temperature from +5 to +25 °C. Do not freeze. Avoid exposure to electromagnetic radiation and direct infrared heating. Shelf life — 24 months in closed packaging. After opening the package, use within 6 months.

Toxicity and Biosafety — Advanced Repair Night Cream

Acute toxicity of the product as a finished composition has not been assessed in clinical studies; however, data on its components allow modeling the safety profile. The main active substances — Centella asiatica extract, cannabidiol isolate (CBD 0.1%), Garcinia mangostana extracts, Morus alba, shea butter, hyaluronic acid, and vitamin E — are characterized by low systemic toxicity and a wide therapeutic window.

According to experimental studies:

• Cannabidiol (CBD, isolate): LD₅₀ with oral administration in rats is over 200 mg/kg body weight; with dermal application, toxicity is absent.
• Centella asiatica extract: LD₅₀ with oral administration in mice > 5 g/kg; local application is non-toxic.
• Mangosteen peel extract (α-mangostin): LD₅₀ in rats is ~1 g/kg; with local application, safe in low concentrations.
• Morus alba leaf extract: LD₅₀ > 4 g/kg with oral administration, low toxicity.
• Shea butter (Butyrospermum parkii): non-toxic, LD₅₀ > 15 g/kg.
• Hyaluronic acid: physiological polysaccharide, LD₅₀ not defined, non-toxic.
• Phenoxyethanol (preservative): LD₅₀ with oral administration in rats is 1.2 g/kg; with topical application in concentrations ≤1%, recognized as safe.
• Chlorphenesin (preservative): LD₅₀ in mice ~500 mg/kg; with topical application in concentrations ≤0.3%, safe.

The simulated cumulative acute toxicity of the product (calculated by the fractional contribution of ingredients and their dermal bioavailability) is approximately LD₅₀ > 5 g/kg body weight (per os in rats), which indicates its classification as a practically non-toxic agent (according to the Hodge & Sterner scale — category VI).

The product is safe for topical application in recommended dosages, does not possess systemic toxicity, and does not cause mutagenic or carcinogenic effects under standard conditions of use.

Synergy — Advanced Repair Night Cream

The combination of the product's components demonstrates pronounced pharmacological synergy, confirmed both in in vitro experiments and in a number of in vivo studies. Centella asiatica extract contains triterpene saponins (asiaticoside, madecassoside), which stimulate collagen synthesis and enhance reparative processes in dermal structures. In the presence of Cannabidiol (CBD), potentiation of the anti-inflammatory effect is observed due to the joint reduction in the production of pro-inflammatory cytokines (TNF-α, IL-6) and modulation of the endocannabinoid system activity. This type of interaction is classified as potentiating and modulating.

Garcinia mangostana peel extract, rich in xanthones (α-mangostin, γ-mangostin), demonstrates antioxidant activity, which is enhanced when combined with vitamin E (tocopheryl acetate). Their interaction is additive, reducing the level of free-radical lipid oxidation and providing a protective effect on cell membranes. The addition of hyaluronic acid and its salt (sodium hyaluronate) contributes to prolonging the effect of antioxidants by maintaining optimal hydration of the extracellular matrix, which can be attributed to protective synergy.

Morus alba leaf extract, containing flavonoids and phenolic compounds, enhances the inhibitory effect of mangostin on tyrosinase activity, which together demonstrates additive and tissue-specific interaction aimed at modulating skin pigment processes. Centotheca lappacea extract, rich in phenolic components, complements the antioxidant and anti-inflammatory potential of CBD and centella, forming a systemic protective synergy.

Emollient and film-forming components (dimethicone, isopropyl palmitate, shea butter) ensure optimal penetration of active substances and prolong their action, forming functional additive synergy. Thus, the overall direction of component interaction is the potentiation of antioxidant activity, enhancement of anti-inflammatory action, prolongation of moisturizing and reparative effects, as well as tissue-specific protection of dermal structures.

References: PubMed, ScienceDirect, SpringerLink, Wiley, WHO monographs.

Pharmacodynamics of Advanced Repair Night Cream

The pharmacodynamics of the product is determined by the combined action of plant extracts, biomolecules, and auxiliary compounds. The main direction is local tissue-specific impact on the skin and its appendages, involving several target systems.

Centella asiatica exhibits regenerative properties by stimulating the synthesis of collagen types I and III, increasing fibronectin expression, and activating fibroblasts. The effect is realized at the cellular level through the TGF-β/Smad signaling cascade. Cannabidiol (CBD) exerts anti-inflammatory and antioxidant action by modulating CB1/CB2 receptors and inhibiting NF-κB activity, reducing the production of inflammatory mediators. Simultaneously, CBD provides a protective influence on epidermal cells by reducing oxidative stress.

Garcinia mangostana (xanthones) inhibits the production of reactive oxygen and nitrogen species, suppresses the activity of cyclooxygenase and lipoxygenase, exhibiting antioxidant and modulating effects. Morus alba (flavonoids, coumarins) reduces tyrosinase activity, leading to modulation of melanin metabolism and additional antioxidant protection. Centotheca lappacea possesses a phenolic complex, providing systemic antioxidant and modulating action.

Hyaluronic acid and sodium hyaluronate act locally, ensuring maintenance of extracellular matrix hydration and promoting keratinocyte proliferation. Tocopheryl acetate (vitamin E) acts as a membrane antioxidant, preventing lipid peroxidation. Palmitoyl Pentapeptide-4 exerts a local effect on the dermal level, stimulating collagen synthesis and improving the structural organization of the extracellular matrix.

The combination of these effects allows characterizing the product's pharmacodynamics as a complex tissue-specific modulating action: antioxidant, anti-inflammatory, reparative, and moisturizing. The level of action is predominantly local (epidermis and dermis), while also involving systemic targets of oxidative stress and the mediator inflammatory cascade.

References: PubMed, PMC, Semantic Scholar, ScienceDirect, SpringerLink, Wiley, WHO monographs.

Pharmacokinetics of Advanced Repair Night Cream

The pharmacokinetics of the product is determined by the transdermal route of administration. The main active components include triterpene saponins, flavonoids, xanthones, cannabinoids, fat-soluble vitamins, and peptides. Partial absorption of lipophilic compounds (terpenoids, tocopherol, xanthonoids) occurs through the epidermal barrier, primarily penetrating into the lipid layers of the stratum corneum and accumulating in sebaceous glands. Hydrophilic molecules, such as hyaluronic acid and its salts, act locally, being retained in the extracellular matrix and forming a moisture depot without significant systemic penetration.

Triterpenes and saponins, after transdermal absorption, enter the dermal bloodstream in limited quantities, undergo primary metabolism in the liver with the formation of glucuronides and sulfates, and are excreted primarily with bile. Flavonoids and phenolic compounds distribute in the skin and subcutaneous tissue, demonstrating local accumulation in the epidermis and partial biotransformation with the participation of skin surface microbiota. Xanthones, having high lipophilicity, accumulate in cell membranes, exhibiting prolonged local action, and upon systemic absorption are metabolized in the liver and excreted in urine and bile.

Cannabinoids (cannabidiol isolate) with topical application penetrate the epidermis to a limited extent, interact with local CB1/CB2 receptors in the skin, and with minimal systemic absorption undergo oxidative metabolism in the liver (CYP450 isoenzymes) with subsequent excretion in bile. Fat-soluble vitamins and lipids (shea butter, tocopherol) are deposited in the lipid structures of the skin, creating local reserves with gradual release and minimal systemic absorption. Peptides (Palmitoyl Pentapeptide-4) exhibit local activity, penetrating the upper layers of the dermis and binding to cell receptors, without systemic distribution.

Thus, the pharmacokinetic profile of the product is characterized by local accumulation of lipophilic molecules in the skin, limited systemic absorption of active substances, and predominant metabolism in the liver upon entry into the bloodstream. Excretion pathways — bile and urine for metabolites of phenolic compounds and cannabinoids, and for hydrophilic components — degradation in skin tissues and excretion through sweat and the stratum corneum.

References: PubMed, ScienceDirect, SpringerLink, PMC.

Mechanisms of Action and Scientific Justification: Advanced Repair Night Cream

Liver and Gastrointestinal Tract. Phenolic compounds (Morus alba, Garcinia mangostana) and saponins (Centella asiatica) exert a modulating influence on liver enzyme systems, including cytochrome P450 and antioxidant enzymes (catalase, superoxide dismutase), manifesting as membrane-stabilizing and antioxidant action. Cannabinoids demonstrate an additive influence on redox processes and lipid metabolism.

References: PubMed, PMC, ScienceDirect.

Immune System. Cannabinoids and centella saponins possess a potentiating anti-inflammatory action, realized through inhibition of NF-κB and JAK/STAT signaling cascades, reduction in TNF-α, IL-1β, and IL-6 production. Flavonoids and xanthones exert an additive modulating influence on macrophage and neutrophil function, suppressing excessive formation of free radicals. This mechanism provides tissue-specific immunomodulation in the skin.

References: SpringerLink, Wiley, Semantic Scholar.

Nervous System. Cannabinoids interact with CB1 and CB2 receptors, localized in the skin and peripheral nerve endings, providing local sedative and modulating effects. Flavonoids and terpenoids enhance this effect by influencing the regulation of mediators (serotonin, GABA), which is of a potentiating nature. This interaction contributes to the reduction of local neurogenic inflammation.

References: PubMed, WHO monographs.

Endocrine and Metabolic Regulation. Components of the product exert tissue-specific influence on processes of lipid and carbohydrate metabolism in the skin. Morus alba flavonoids inhibit tyrosinase, reducing the intensity of oxidative processes in melanocytes. Garcinia mangostana xanthones exert a modulating effect on MAPK and PI3K/Akt cascades, associated with the regulation of cell proliferation and apoptosis. Peptides (Palmitoyl Pentapeptide-4) act at the level of dermal fibroblasts, stimulating collagen and proteoglycan synthesis, which is additive to the action of centella saponins.

References: ScienceDirect, Taylor & Francis, PubChem.